JP3762407B2 - 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害薬としてのβ−アミノテトラヒドロイミダゾ（１，２−Ａ）ピラジン類及びテトラヒドロトリアゾロ（４，３−Ａ）ピラジン類 - Google Patents

糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害薬としてのβ−アミノテトラヒドロイミダゾ（１，２−Ａ）ピラジン類及びテトラヒドロトリアゾロ（４，３−Ａ）ピラジン類 Download PDF

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Publication number
JP3762407B2
JP3762407B2 JP2003510665A JP2003510665A JP3762407B2 JP 3762407 B2 JP3762407 B2 JP 3762407B2 JP 2003510665 A JP2003510665 A JP 2003510665A JP 2003510665 A JP2003510665 A JP 2003510665A JP 3762407 B2 JP3762407 B2 JP 3762407B2
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compound
mmol
acid
phenyl
alkyl
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Expired - Lifetime
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JP2004536115A5 (enExample
JP2004536115A (ja
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エドモンドソン，スコツト・デイー
フイツシヤー，マイケル・エイチ
キム，ドウソプ
マツコス，マルコム
パーミー，エマ・アール
ウイーバー，アン・イー
シユー，チンヨウ
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Merck and Co Inc
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Merck and Co Inc
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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JP2003510665A 2001-07-06 2002-07-05 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害薬としてのβ−アミノテトラヒドロイミダゾ（１，２−Ａ）ピラジン類及びテトラヒドロトリアゾロ（４，３−Ａ）ピラジン類 Expired - Lifetime JP3762407B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (3)

Publication Number Publication Date
JP2004536115A JP2004536115A (ja) 2004-12-02
JP2004536115A5 JP2004536115A5 (enExample) 2005-12-22
JP3762407B2 true JP3762407B2 (ja) 2006-04-05

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JP2003510665A Expired - Lifetime JP3762407B2 (ja) 2001-07-06 2002-07-05 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害薬としてのβ−アミノテトラヒドロイミダゾ（１，２−Ａ）ピラジン類及びテトラヒドロトリアゾロ（４，３−Ａ）ピラジン類

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US (9) US6699871B2 (enExample)
EP (4) EP2292232B1 (enExample)
JP (1) JP3762407B2 (enExample)
KR (1) KR100606871B1 (enExample)
CN (2) CN1861077A (enExample)
AR (1) AR036114A1 (enExample)
AT (2) ATE471148T1 (enExample)
AU (1) AU2002320303B2 (enExample)
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CA (1) CA2450740C (enExample)
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CY (3) CY2007019I2 (enExample)
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DO (1) DOP2002000438A (enExample)
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EP4548914A1 (en) 2023-11-02 2025-05-07 Sawai Pharmaceutical Co., Ltd. Sitagliptin preparation and method of storage thereof

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ZA200309294B (en) 2004-07-22
US8440668B2 (en) 2013-05-14
US20040167133A1 (en) 2004-08-26
EP1625847A1 (en) 2006-02-15
CY2007019I2 (el) 2017-07-12
ECSP044935A (es) 2004-02-26
EA012701B1 (ru) 2009-12-30
HU225695B1 (hu) 2007-06-28
HUP0401104A2 (hu) 2004-09-28
RS50737B (sr) 2010-08-31
US20060270679A1 (en) 2006-11-30
NL300357I1 (nl) 2008-10-01
MXPA04000018A (es) 2004-05-21
IS2218B (is) 2007-03-15
US6699871B2 (en) 2004-03-02
IS2964B (is) 2017-02-15
CY1110784T1 (el) 2015-06-10
FR08C0033I2 (fr) 2010-12-31
NO2007010I2 (no) 2009-12-14
KR100606871B1 (ko) 2006-08-01
US20100130504A1 (en) 2010-05-27
FR08C0033I1 (enExample) 2008-09-26
CA2450740A1 (en) 2003-01-16
HK1068882A1 (en) 2005-05-06
HUS0700005I1 (hu) 2022-01-28
LTC1412357I2 (lt) 2021-01-11
NO321999B1 (no) 2006-07-31
IS8617A (is) 2007-03-06
CA2450740C (en) 2006-02-14
PE20030654A1 (es) 2003-07-29
CY2007019I1 (el) 2009-11-04
BE2007C047I2 (enExample) 2021-06-04
PT1412357E (pt) 2006-07-31
BRPI0210866B8 (pt) 2021-05-25
KR20040010842A (ko) 2004-01-31
EP1412357A1 (en) 2004-04-28
EP1412357B1 (en) 2006-03-22
DE60210093T2 (de) 2006-11-23
LU91470I2 (fr) 2008-10-20
ME00439B (me) 2011-12-20
JP2004536115A (ja) 2004-12-02
CN1861077A (zh) 2006-11-15
WO2003004498A1 (en) 2003-01-16
CY2008014I1 (el) 2009-11-04
BR0210866A (pt) 2004-06-29
DE122007000056I1 (de) 2007-12-13
NL300287I2 (nl) 2009-04-01
HUP0401104A3 (en) 2006-02-28
EP2292232A1 (en) 2011-03-09
US20200206221A1 (en) 2020-07-02
CN1290848C (zh) 2006-12-20
CR7235A (es) 2006-05-31
EA200501805A1 (ru) 2006-06-30
DE60210093D1 (de) 2006-05-11
US20150359793A1 (en) 2015-12-17
US8168637B2 (en) 2012-05-01
YU100603A (sh) 2006-05-25
NO2007010I1 (no) 2007-09-17
PL196278B1 (pl) 2007-12-31
US20170348309A1 (en) 2017-12-07
PL367279A1 (en) 2005-02-21
BRPI0210866B1 (pt) 2016-07-05
DE122008000046I1 (de) 2009-02-05
US20110190308A1 (en) 2011-08-04
EP1625847B1 (en) 2010-06-16
GEP20053734B (en) 2006-01-10
JO2230B1 (en) 2004-10-07
TWI226331B (en) 2005-01-11
DK1412357T3 (da) 2006-07-17
FR07C0041I1 (enExample) 2007-10-19
US20130217695A1 (en) 2013-08-22
LUC91360I2 (enExample) 2020-06-12
EP2226324A1 (en) 2010-09-08
ES2259713T3 (es) 2006-10-16
PT1625847E (pt) 2010-08-20
US20030100563A1 (en) 2003-05-29
NL300357I2 (nl) 2009-01-05
US7125873B2 (en) 2006-10-24
ES2344846T3 (es) 2010-09-08
ATE321048T1 (de) 2006-04-15
SI1412357T1 (sl) 2006-06-30
LUC91360I1 (enExample) 2020-04-23
MA27053A1 (fr) 2004-12-20
NO2008013I1 (no) 2008-09-08
DOP2002000438A (es) 2003-01-31
MY127961A (en) 2007-01-31
UA74912C2 (en) 2006-02-15
IS7062A (is) 2003-11-28
GEP20063734B (en) 2006-01-10
DK1625847T3 (da) 2010-10-18
PL196278B6 (pl) 2023-02-13
CN1524082A (zh) 2004-08-25
DE60236767D1 (de) 2010-07-29
LTPA2007006I1 (lt) 2020-04-27
NZ529833A (en) 2005-01-28
CY2008014I2 (el) 2009-11-04
AU2002320303B2 (en) 2004-10-14

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