|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4716224A
(en)
|
1984-05-04 |
1987-12-29 |
Seikagaku Kogyo Co. Ltd. |
Crosslinked hyaluronic acid and its use
|
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
US4937270A
(en)
|
1987-09-18 |
1990-06-26 |
Genzyme Corporation |
Water insoluble derivatives of hyaluronic acid
|
|
EP0326111A3
(en)
|
1988-01-29 |
1989-12-27 |
New York Blood Center, Inc. |
Peptide derivatives rendered immunogenic when administered with alum as an adjuvant
|
|
IT1219587B
(it)
|
1988-05-13 |
1990-05-18 |
Fidia Farmaceutici |
Polisaccaridi carbossiilici autoreticolati
|
|
FI903489A0
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
|
|
SE8900422D0
(sv)
|
1989-02-08 |
1989-02-08 |
Pharmacia Ab |
Tvaerbundna hyaluronatgeler samt foerfarande foer framstaellning av dessa
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5356883A
(en)
|
1989-08-01 |
1994-10-18 |
Research Foundation Of State University Of N.Y. |
Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
ES2160207T3
(es)
|
1990-06-14 |
2001-11-01 |
Integra Lifesciences Corp |
Aposito para herida y fijacion de un cateter que usa un material compuesto de poliuretano-biopolimero.
|
|
JPH06502391A
(ja)
|
1990-07-26 |
1994-03-17 |
ジー.ディー.サール アンド カンパニー |
ポリマー性薬剤送達システム
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
US5144088A
(en)
|
1991-04-26 |
1992-09-01 |
Aristech Chemical Corporation |
Manufacture of neopentyl glycol (I)
|
|
EP0940468A1
(en)
|
1991-06-14 |
1999-09-08 |
Genentech, Inc. |
Humanized antibody variable domain
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
EP0604580A1
(en)
|
1991-09-19 |
1994-07-06 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
WO1993009176A2
(en)
|
1991-10-29 |
1993-05-13 |
Clover Consolidated, Limited |
Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
|
DE69333807T2
(de)
|
1992-02-06 |
2006-02-02 |
Chiron Corp., Emeryville |
Marker für krebs und biosynthetisches bindeprotein dafür
|
|
US5514379A
(en)
|
1992-08-07 |
1996-05-07 |
The General Hospital Corporation |
Hydrogel compositions and methods of use
|
|
GB9216925D0
(en)
|
1992-08-10 |
1992-09-23 |
Royal Holloway |
Microspheres of polyhydroxylic materials
|
|
JP3107488B2
(ja)
|
1993-09-29 |
2000-11-06 |
株式会社資生堂 |
架橋ヒアルロン酸を用いた徐放性製剤及び塞栓剤
|
|
DE69530553T2
(de)
|
1994-05-13 |
2004-03-25 |
KURARAY CO., LTD, Kurashiki |
Medizinisches polymergel
|
|
US6063396A
(en)
|
1994-10-26 |
2000-05-16 |
Houston Biotechnology Incorporated |
Methods and compositions for the modulation of cell proliferation and wound healing
|
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
|
US5690961A
(en)
|
1994-12-22 |
1997-11-25 |
Hercules Incorporated |
Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
|
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
IT1281886B1
(it)
|
1995-05-22 |
1998-03-03 |
Fidia Advanced Biopolymers Srl |
Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro
|
|
US5612321A
(en)
|
1995-06-22 |
1997-03-18 |
Hercules Incorporated |
Antioxidant grafted polysaccharides
|
|
JP3130234B2
(ja)
|
1995-09-29 |
2001-01-31 |
デンセイ・ラムダ株式会社 |
インバータ装置
|
|
DE69739656D1
(de)
|
1996-02-09 |
2009-12-31 |
Amgen Inc |
1 inhibitor und hyaluronan als polymer mit verzögerter wirkstofffreigabe
|
|
US6566406B1
(en)
|
1998-12-04 |
2003-05-20 |
Incept, Llc |
Biocompatible crosslinked polymers
|
|
CA2294756C
(en)
|
1997-07-03 |
2008-04-29 |
Orquest, Inc. |
Cross-linked polysaccharide drug carrier
|
|
JPH1133104A
(ja)
|
1997-07-16 |
1999-02-09 |
Res Inst For Prod Dev |
生体組織への接着性を有する医用材料
|
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
|
AU760562B2
(en)
|
1997-12-05 |
2003-05-15 |
Scripps Research Institute, The |
Humanization of murine antibody
|
|
US6624142B2
(en)
|
1997-12-30 |
2003-09-23 |
Enzon, Inc. |
Trimethyl lock based tetrapartate prodrugs
|
|
CA2332802A1
(en)
|
1998-05-20 |
1999-11-25 |
Chugai Seiyaku Kabushiki Kaisha |
Conjugate of therapeutic agent for joint disease and hyaluronic acid
|
|
ITPD980169A1
(it)
|
1998-07-06 |
2000-01-06 |
Fidia Advanced Biopolymers Srl |
Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
|
|
US6630457B1
(en)
|
1998-09-18 |
2003-10-07 |
Orthogene Llc |
Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
|
|
JP2000119196A
(ja)
|
1998-10-07 |
2000-04-25 |
Menicon Co Ltd |
眼科用薬剤徐放材及びその製造方法
|
|
IT1303735B1
(it)
|
1998-11-11 |
2001-02-23 |
Falorni Italia Farmaceutici S |
Acidi ialuronici reticolati e loro usi medici.
|
|
EP1162984A2
(en)
|
1999-03-15 |
2001-12-19 |
Trustees Of Boston University |
Use of cross linked polysaccharides for the inhibition of angiogenesis
|
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
|
DE60022369T2
(de)
|
1999-10-04 |
2006-05-18 |
Medicago Inc., Sainte Foy |
Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff
|
|
AU2574701A
(en)
|
1999-11-26 |
2001-06-12 |
Regents Of The University Of Michigan, The |
Reversible cross-linked hydrogels
|
|
WO2001044463A1
(en)
|
1999-12-15 |
2001-06-21 |
Genentech, Inc. |
Shotgun scanning, a combinatorial method for mapping functional protein epitopes
|
|
ES2637801T3
(es)
|
2000-04-11 |
2017-10-17 |
Genentech, Inc. |
Anticuerpos multivalentes y usos de los mismos
|
|
DK1305057T3
(da)
|
2000-07-31 |
2005-10-24 |
Iscience Corp |
Mikropartikelformig biomaterialesammensætning af hyaluronsyre til medicinsk anvendelse
|
|
IT1317358B1
(it)
|
2000-08-31 |
2003-06-16 |
Fidia Advanced Biopolymers Srl |
Derivati cross-linkati dell'acido ialuronico.
|
|
EP1355566B1
(en)
|
2000-12-18 |
2012-11-28 |
Board Of Regents, The University Of Texas System |
Local regional chemotherapy and radiotherapy using in situ hydrogel
|
|
EP1368309B2
(en)
|
2001-02-22 |
2014-10-01 |
Anika Therapeutics Inc. |
Thiol-modified hyaluronan
|
|
ITMI20011238A1
(it)
|
2001-06-12 |
2002-12-12 |
Bartholdy Consultadoria E Serv |
Polimeri polisaccaridici di origine naturale coniugati chimicamente asostanze farmacologicamente o biologicamente attive e loro proprieta'
|
|
ITPD20020064A1
(it)
|
2002-03-12 |
2003-09-12 |
Fidia Advanced Biopolymers Srl |
Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
|
|
WO2003082316A1
(en)
|
2002-03-29 |
2003-10-09 |
The Regents Of The University Of California |
Microgel particles for the delivery of bioactive materials
|
|
JPWO2003084571A1
(ja)
|
2002-04-08 |
2005-08-11 |
電気化学工業株式会社 |
骨感染症治療用組成物
|
|
ES2566761T3
(es)
|
2002-05-30 |
2016-04-15 |
The Scripps Research Institute |
Ligación de azidas y acetilenos catalizada por cobre
|
|
JP4753578B2
(ja)
|
2002-06-03 |
2011-08-24 |
ジェネンテック, インコーポレイテッド |
合成抗体ファージライブラリー
|
|
KR100507545B1
(ko)
|
2002-09-03 |
2005-08-09 |
주식회사 엘지생명과학 |
히알루론산 유도체 및 그의 제조방법
|
|
JP5156890B2
(ja)
|
2002-09-11 |
2013-03-06 |
独立行政法人物質・材料研究機構 |
高分子架橋体及びその製造方法
|
|
AU2003284634A1
(en)
|
2002-11-21 |
2004-06-15 |
Chugai Seiyaku Kabushiki Kaisha |
Sustained release drug carrier
|
|
CA2509382A1
(en)
|
2002-12-17 |
2004-07-08 |
Todd C. Zion |
Stimuli-responsive systems for controlled drug delivery
|
|
US20050079574A1
(en)
|
2003-01-16 |
2005-04-14 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
CA2513483C
(en)
|
2003-01-17 |
2011-11-29 |
Cornell Research Foundation, Inc. |
Injectable hydrogel microspheres from aqueous two-phase system
|
|
US7332164B2
(en)
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
CA2843439A1
(en)
|
2003-04-08 |
2004-10-21 |
Yeda Research And Development Co. Ltd |
Reversible pegylated drugs
|
|
AU2003901834A0
(en)
|
2003-04-17 |
2003-05-01 |
Clearcoll Pty Ltd |
Cross-linked polysaccharide compositions
|
|
MXPA05011311A
(es)
|
2003-04-25 |
2005-12-12 |
Kos Life Sciences Inc |
Formacion de hidrogeles super porosos fuertes.
|
|
JP2004323454A
(ja)
|
2003-04-25 |
2004-11-18 |
Chisso Corp |
薬剤
|
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
WO2005044853A2
(en)
*
|
2003-11-01 |
2005-05-19 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
WO2005034852A2
(en)
|
2003-08-26 |
2005-04-21 |
Gel-Del Technologies, Inc. |
Protein biomaterials and biocoacervates and methods of making and using thereof
|
|
US7690003B2
(en)
|
2003-08-29 |
2010-03-30 |
Fuller Jeffrey C |
System and method for increasing data throughput using thread scheduling
|
|
US8124120B2
(en)
|
2003-12-22 |
2012-02-28 |
Anika Therapeutics, Inc. |
Crosslinked hyaluronic acid compositions for tissue augmentation
|
|
EP1576952A1
(en)
|
2004-03-18 |
2005-09-21 |
OctoPlus Technologies B.V. |
Hydrogel microspheres with improved release profile
|
|
JP4950022B2
(ja)
|
2004-03-23 |
2012-06-13 |
コンプレックス バイオシステムズ ゲーエムベーハー |
自壊性リンカーを有する高分子プロドラッグ
|
|
RU2386638C2
(ru)
|
2004-03-31 |
2010-04-20 |
Дженентек, Инк. |
Гуманизированные анти-тфр-бета-антитела
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
US20050244472A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
|
|
US8293890B2
(en)
|
2004-04-30 |
2012-10-23 |
Advanced Cardiovascular Systems, Inc. |
Hyaluronic acid based copolymers
|
|
GB0411583D0
(en)
|
2004-05-24 |
2004-06-23 |
Univ Bath |
Process
|
|
US7968085B2
(en)
|
2004-07-05 |
2011-06-28 |
Ascendis Pharma A/S |
Hydrogel formulations
|
|
WO2006113668A1
(en)
|
2005-04-15 |
2006-10-26 |
University Of South Florida |
A method of transdermal drug delivery using hyaluronic acid nanoparticles
|
|
GB2427360A
(en)
|
2005-06-22 |
2006-12-27 |
Complex Biosystems Gmbh |
Aliphatic prodrug linker
|
|
WO2007004675A1
(ja)
|
2005-07-06 |
2007-01-11 |
Seikagaku Corporation |
薬剤導入光架橋ヒアルロン酸誘導体ゲル
|
|
US8679536B2
(en)
|
2005-08-24 |
2014-03-25 |
Actamax Surgical Materials, Llc |
Aldol-crosslinked polymeric hydrogel adhesives
|
|
CA2620663A1
(en)
|
2005-09-02 |
2007-03-08 |
Colbar Lifescience Ltd. |
Cross-linked polysaccharide and protein matrices and methods for their preparation
|
|
KR20080067619A
(ko)
|
2005-09-15 |
2008-07-21 |
유니버시티 오브 유타 리써치 파운데이션 |
고분자 조성물 및 이의 제조방법, 및 이의 용도
|
|
US20090130769A1
(en)
|
2005-09-21 |
2009-05-21 |
Universiteit Van Amsterdam |
Novel Cross-Linkers For Obtaining Structure Information On Molecule Complexes
|
|
US20080306022A1
(en)
|
2005-10-12 |
2008-12-11 |
Kenji Miyamoto |
Agent for Applying to Mucosa and Method for the Production Thereof
|
|
WO2007047922A2
(en)
|
2005-10-19 |
2007-04-26 |
Smartcells, Inc. |
Polymer-drug conjugates
|
|
EP1957531B1
(en)
|
2005-11-07 |
2016-04-13 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
|
EP1973951A2
(en)
|
2005-12-02 |
2008-10-01 |
Genentech, Inc. |
Binding polypeptides with restricted diversity sequences
|
|
CA2633954A1
(en)
|
2005-12-14 |
2007-06-21 |
Anika Therapeutics, Inc. |
Meniscal implant of hyaluronic acid derivatives for treatment of meniscal defects
|
|
US7879818B2
(en)
|
2005-12-23 |
2011-02-01 |
Janos Borbely |
Hyaluronic acid-based cross-linked nanoparticles
|
|
US20070202186A1
(en)
|
2006-02-22 |
2007-08-30 |
Iscience Interventional Corporation |
Apparatus and formulations for suprachoroidal drug delivery
|
|
CA2649915A1
(en)
|
2006-04-20 |
2007-11-01 |
University Of Utah Research Foundation |
Polymeric compositions and methods of making and using thereof
|
|
WO2007134050A2
(en)
|
2006-05-09 |
2007-11-22 |
Genentech, Inc. |
Binding polypeptides with optimized scaffolds
|
|
EP2059533B1
(en)
|
2006-08-30 |
2012-11-14 |
Genentech, Inc. |
Multispecific antibodies
|
|
ITMI20061726A1
(it)
|
2006-09-11 |
2008-03-12 |
Fidia Farmaceutici |
Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
|
|
CN101534643A
(zh)
|
2006-09-15 |
2009-09-16 |
安佐制药股份有限公司 |
用于递送寡核苷酸的基于位阻酯的生物可降解连接体
|
|
JP5694664B2
(ja)
|
2006-09-29 |
2015-04-01 |
サーモディクス,インコーポレイティド |
生分解性眼用インプラント及び眼の病気を治療する方法
|
|
EP1942117A1
(en)
|
2006-12-29 |
2008-07-09 |
Sigea S.R.L. |
Derivatives of acid polysaccharides
|
|
KR20080073419A
(ko)
|
2007-02-06 |
2008-08-11 |
주식회사 핸슨바이오텍 |
의료용 히알루론산 유도체 마이크로비드 및 이의 제조 방법
|
|
EP1992364A1
(en)
|
2007-05-16 |
2008-11-19 |
Biosuma S.r.l. |
Carboxylated polysaccharides phosphated or bisphosphonated derivatives, optionally cross-linked, and their preparation and biomedical uses
|
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
|
EP2175878A4
(en)
|
2007-07-11 |
2014-12-03 |
Belrose Pharma Inc |
POLYMER DRUG DISPENSING SYSTEM WITH A MULTIPLE SUBSTITUTED AROMATIC PART
|
|
US8318695B2
(en)
|
2007-07-30 |
2012-11-27 |
Allergan, Inc. |
Tunably crosslinked polysaccharide compositions
|
|
EP2090592A1
(en)
|
2007-07-31 |
2009-08-19 |
OctoPlus Sciences B.V. |
Biodegradable hydrogels based on click chemistry
|
|
KR101062320B1
(ko)
|
2007-08-01 |
2011-09-05 |
포항공과대학교 산학협력단 |
가교결합성 히알루론산 유도체 제조방법 및 그 히알루론산유도체의 가교결합물
|
|
WO2009022358A1
(en)
|
2007-08-10 |
2009-02-19 |
Luigi Ambrosio |
Superabsorbent polymer hydro gels and a method of preparing thereof
|
|
WO2009048280A2
(en)
|
2007-10-09 |
2009-04-16 |
Postech Academy-Industry Foundation |
Long acting hyaluronic acid - peptide conjugate
|
|
SG185281A1
(en)
|
2007-10-11 |
2012-11-29 |
Inserm Inst Nat De Sante Et De La Rech Medicale |
Method for preparing porous scaffold for tissue engineering
|
|
WO2009047346A1
(en)
|
2007-10-11 |
2009-04-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method for preparing porous scaffold for tissue engineering, cell culture and cell delivery
|
|
US20090143348A1
(en)
|
2007-11-30 |
2009-06-04 |
Ahmet Tezel |
Polysaccharide gel compositions and methods for sustained delivery of drugs
|
|
US8394782B2
(en)
|
2007-11-30 |
2013-03-12 |
Allergan, Inc. |
Polysaccharide gel formulation having increased longevity
|
|
EP2222715B1
(en)
|
2007-12-19 |
2019-07-24 |
Evonik Degussa GmbH |
Crosslinked hyaluronic acid in emulsion
|
|
AU2008341180A1
(en)
|
2007-12-21 |
2009-07-02 |
Encecor Ab |
Cross-linked hydrogel containing an active substance
|
|
SI2235064T1
(sl)
|
2008-01-07 |
2016-04-29 |
Amgen Inc. |
Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
|
|
CN101980725B
(zh)
|
2008-02-01 |
2013-06-12 |
阿森迪斯药物股份有限公司 |
包含可自裂解的连接体的前药
|
|
CN101538377A
(zh)
|
2008-03-20 |
2009-09-23 |
上海昊海生物科技有限公司 |
一种交联透明质酸凝胶及其制备方法
|
|
IE20080211A1
(en)
|
2008-03-20 |
2009-11-25 |
Nat Univ Ireland |
Biodegradable nanoshells for delivery of therapeutic and/or imaging molecules
|
|
CN102046661A
(zh)
|
2008-03-28 |
2011-05-04 |
加利福尼亚大学董事会 |
多肽-聚合物偶联物和其使用方法
|
|
EP2288261A4
(en)
|
2008-05-23 |
2013-09-25 |
Enzon Pharmaceuticals Inc |
POLYMER SYSTEMS CONTAINING INTRA-CELLULAR RELEASE DISULFID LINKERS FOR THE DISPOSAL OF OLIGONUCLEOTIDES
|
|
US8821870B2
(en)
|
2008-07-18 |
2014-09-02 |
Allergan, Inc. |
Method for treating atrophic age related macular degeneration
|
|
US8357795B2
(en)
|
2008-08-04 |
2013-01-22 |
Allergan, Inc. |
Hyaluronic acid-based gels including lidocaine
|
|
GB0816496D0
(en)
|
2008-09-10 |
2008-10-15 |
Zhao Xiaobin |
Hyaluronic acid cryogel
|
|
CN101721349B
(zh)
|
2008-10-16 |
2011-07-20 |
常州百瑞吉生物医药有限公司 |
可注射原位交联水凝胶及其制备方法和用途
|
|
US20100098772A1
(en)
*
|
2008-10-21 |
2010-04-22 |
Allergan, Inc. |
Drug delivery systems and methods for treating neovascularization
|
|
ITRM20080636A1
(it)
|
2008-11-28 |
2010-05-29 |
Univ Palermo |
Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
|
|
US8133979B2
(en)
|
2008-12-16 |
2012-03-13 |
Hoffmann-La Roche Inc. |
Antibodies against human angiopoietin 2
|
|
US11090387B2
(en)
|
2008-12-22 |
2021-08-17 |
The Trustees Of The University Of Pennsylvania |
Hydrolytically degradable polysaccharide hydrogels
|
|
FR2945949B1
(fr)
|
2009-05-26 |
2011-05-13 |
Anteis Sa |
Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme.
|
|
US20120076787A1
(en)
*
|
2009-05-28 |
2012-03-29 |
Peter Adamson |
Combination of a tnf-alpha antagonist and a vegf antagonist for use in the treatment or prevention of diseases of the eye
|
|
WO2010138074A1
(en)
|
2009-05-29 |
2010-12-02 |
Hilborn Joens |
Hyaluronic acid based delivery systems
|
|
IT1399351B1
(it)
|
2009-06-16 |
2013-04-16 |
Fidia Farmaceutici |
Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
|
|
KR101091028B1
(ko)
|
2009-07-02 |
2011-12-09 |
아주대학교산학협력단 |
체내 주입형 하이드로젤 및 이의 생의학적 용도
|
|
ES2574238T3
(es)
|
2009-07-02 |
2016-06-16 |
Actamax Surgical Materials Llc |
Adhesivo tisular de hidrogel para uso médico
|
|
ES2833035T3
(es)
|
2009-07-31 |
2021-06-14 |
Ascendis Pharma As |
Hidrogeles biodegradables insolubles en agua a base de polietilenglicol
|
|
US9173953B2
(en)
|
2009-07-31 |
2015-11-03 |
Ascendis Pharma As |
Prodrugs containing an aromatic amine connected by an amido bond to a linker
|
|
US8753687B2
(en)
|
2009-08-11 |
2014-06-17 |
Agency For Science, Technology And Research |
Particulate hyaluronic acid/flavonoid suspensions for cellular delivery of bioactive agents
|
|
JO3008B1
(ar)
|
2009-08-13 |
2016-09-05 |
Seikagaku Kogyo Co Ltd |
تركيب صيدلي لتخفيف الألم
|
|
KR101103423B1
(ko)
|
2009-09-04 |
2012-01-06 |
아주대학교산학협력단 |
생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도
|
|
US20120282211A1
(en)
*
|
2009-11-24 |
2012-11-08 |
Carnegie Mellon University |
Antibodies and conjugates for modulators of angiogenesis
|
|
EP2515957B1
(en)
|
2009-12-22 |
2015-07-29 |
Lifebond Ltd |
Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
|
|
US20120289571A1
(en)
|
2009-12-31 |
2012-11-15 |
Enzon Pharmaceuticals, Inc. |
Polymeric conjugates of aromatic amine containing compounds including releasable urea linker
|
|
US20130030359A1
(en)
|
2010-01-22 |
2013-01-31 |
Ascendis Pharma A/S |
Dipeptide-based prodrug linkers for aromatic amine-containing drugs
|
|
US9561285B2
(en)
|
2010-01-22 |
2017-02-07 |
Ascendis Pharma As |
Carrier-linked carbamate prodrug linkers
|
|
US9062094B2
(en)
|
2010-01-22 |
2015-06-23 |
Ascendis Pharma As |
Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
|
|
WO2011109129A1
(en)
|
2010-03-01 |
2011-09-09 |
Tautona Group Lp |
Threads of cross-linked hyaluronic acid and methods of use thereof
|
|
EP2552416B1
(en)
|
2010-03-29 |
2017-10-25 |
Evonik Corporation |
Compositions and methods for improved retention of a pharmaceutical composition at a local administration site
|
|
EP3604264A1
(en)
|
2010-04-27 |
2020-02-05 |
SynAffix B.V. |
Fused cyclooctyne compounds
|
|
JP5977229B2
(ja)
|
2010-05-05 |
2016-08-24 |
プロリンクス リミテッド ライアビリティ カンパニー |
巨大分子共役体からの徐放
|
|
DK2566334T3
(en)
|
2010-05-05 |
2018-07-23 |
Prolynx Llc |
MANAGED PHARMACEUTICAL RELEASE FROM SOLID CARRIERS
|
|
WO2011148116A2
(fr)
|
2010-05-27 |
2011-12-01 |
Laboratoire Idenov |
Acide hyaluronique modifie, procede de fabrication et utilisations
|
|
US9694081B2
(en)
|
2010-06-21 |
2017-07-04 |
The Trustees Of The University Of Pennsylvania |
Protease triggered release of molecules from hydrogels
|
|
CA2802557A1
(en)
|
2010-06-22 |
2011-12-29 |
Universite De Rouen |
Improved crosslinked hyaluronan hydrogels for 3d cell culture
|
|
IT1401498B1
(it)
|
2010-07-30 |
2013-07-26 |
Mero Srl |
Idrogelo a base di acido ialuronico e suo uso in ortopedia
|
|
ES2645860T3
(es)
|
2010-10-20 |
2017-12-11 |
Allergan Holdings France S.A.S. |
Hilos de ácido hialurónico reticulado y uso de los mismos
|
|
FR2967677B1
(fr)
|
2010-11-18 |
2014-05-16 |
Centre Nat Rech Scient |
Derives de polysaccharides comprenant un motif alcene et reaction de couplage par chimie thio-clic
|
|
US20140038826A1
(en)
|
2011-01-28 |
2014-02-06 |
The Regents Of The University Of Colorado, A Body Corporate |
Covalently cross linked hydrogels and methods of making and using same
|
|
EP2682409B1
(en)
|
2011-03-03 |
2017-07-05 |
Chugai Seiyaku Kabushiki Kaisha |
Derivative of hyaluronic acid modified with amino-carboxylic acid
|
|
CZ304072B6
(cs)
|
2011-04-26 |
2013-09-25 |
Contipro Biotech S.R.O. |
Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
|
|
JP6359966B2
(ja)
|
2011-04-28 |
2018-07-18 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド
|
|
WO2012165462A1
(ja)
|
2011-05-31 |
2012-12-06 |
国立大学法人 東京大学 |
ハイドロゲル及びその製造方法
|
|
US9149422B2
(en)
|
2011-06-03 |
2015-10-06 |
Allergan, Inc. |
Dermal filler compositions including antioxidants
|
|
CN102226009B
(zh)
|
2011-06-09 |
2013-04-10 |
西安力邦制药有限公司 |
一种交联透明质酸凝胶的制备方法
|
|
EP2720722A4
(en)
|
2011-06-16 |
2014-12-03 |
Univ Hong Kong Science & Techn |
MOLECULAR WITH SEVERAL VINYL SULPHONES
|
|
US20140249093A1
(en)
|
2011-08-12 |
2014-09-04 |
Ascendis Pharma A/S |
Carrier-Linked Prodrugs Having Reversible Carboxylic Ester Linkages
|
|
US9044515B2
(en)
|
2011-09-06 |
2015-06-02 |
University Of Delaware |
Chemical conjugates for targeted degradation under reducing conditions
|
|
EP2755691B1
(en)
|
2011-09-07 |
2018-08-22 |
Prolynx LLC |
Hydrogels with biodegradable crosslinking
|
|
WO2013036857A1
(en)
|
2011-09-07 |
2013-03-14 |
Prolynx Llc |
Sulfone linkers
|
|
WO2013036748A1
(en)
|
2011-09-09 |
2013-03-14 |
Berry, Lana, L. |
Bicyclo[6.1.0]non-4-yne reagents for chemical modification of oligonucleotides
|
|
KR102049124B1
(ko)
|
2011-10-11 |
2019-11-26 |
알레간 홀딩스 프랑스 에스.아.에스. |
교차-결합된 히알루론산의 섬조 및 이들의 이용 방법
|
|
MY171920A
(en)
*
|
2011-10-12 |
2019-11-07 |
Ascendis Pharma Ophthalmology Div A/S |
Prevention and treatment of ocular conditions
|
|
CN103917256A
(zh)
|
2011-11-11 |
2014-07-09 |
米巴医疗股份有限公司 |
注射用填充物
|
|
US20140107025A1
(en)
|
2012-04-16 |
2014-04-17 |
Jade Therapeutics, Llc |
Ocular drug delivery system
|
|
EP2841109A1
(en)
|
2012-04-25 |
2015-03-04 |
Ascendis Pharma A/S |
Prodrugs of hydroxyl-comprising drugs
|
|
KR101374271B1
(ko)
|
2012-05-02 |
2014-03-14 |
주식회사 제네웰 |
히알루론산 에폭사이드 가교체 및 그 제조방법
|
|
CA2873793C
(en)
|
2012-05-18 |
2022-02-22 |
Medical Research Council |
Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase
|
|
EP2872534B1
(en)
|
2012-07-13 |
2018-08-08 |
Roche Glycart AG |
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
|
|
CZ304512B6
(cs)
|
2012-08-08 |
2014-06-11 |
Contipro Biotech S.R.O. |
Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
|
|
US9827321B2
(en)
|
2012-08-14 |
2017-11-28 |
The Trustees Of The University Of Pennsylvania |
Stabilizing shear-thinning hydrogels
|
|
KR101445265B1
(ko)
|
2012-09-18 |
2014-09-30 |
포항공과대학교 산학협력단 |
히알루론산-핵산 접합체 및 이를 포함하는 핵산 전달용 조성물
|
|
US9644076B2
(en)
|
2012-09-25 |
2017-05-09 |
Max-Planck-Gesellschaft zur Foerderung der Wissenschafen e. V. |
Cross-linkers for hydrogels, hydrogels including these cross-linkers and applications thereof
|
|
SG11201501914XA
(en)
|
2012-10-11 |
2015-05-28 |
Ascendis Pharma Ophthalmology Division As |
Vegf neutralizing prodrugs for the treatment of ocular conditions
|
|
CN102942699B
(zh)
|
2012-10-26 |
2014-07-02 |
暨南大学 |
一种自增强双交联透明质酸水凝胶及其制备方法
|
|
CN102911380B
(zh)
|
2012-10-29 |
2015-03-18 |
北京爱美客生物科技有限公司 |
透明质酸与生物可降解高分子改性材料及制备方法
|
|
US9220807B2
(en)
|
2012-11-04 |
2015-12-29 |
Miba Medical Inc. |
Non-toxic cross-linker for hyaluronic acid
|
|
EP2727597A1
(en)
|
2012-11-06 |
2014-05-07 |
Centre National de la Recherche Scientifique (CNRS) |
Glucose responsive hydrogel comprising pba-grafted hyaluronic acid (ha)
|
|
ITPD20120360A1
(it)
|
2012-11-30 |
2014-05-31 |
Fidia Farmaceutici |
"nuovi geli viscoelastici in chirurgia oftalmica"
|
|
MX2015007931A
(es)
*
|
2012-12-18 |
2015-10-05 |
Novartis Ag |
Composiciones y metodos que utilizan una etiqueta de peptido que se une a hialuronano.
|
|
WO2014096257A1
(en)
|
2012-12-19 |
2014-06-26 |
Novozymes Biopharma Dk A/S |
Freeze-dried cross-linked hyaluronic acid sponge
|
|
US9498539B2
(en)
|
2012-12-27 |
2016-11-22 |
Molly Sandra Shoichet |
Affinity-based controlled release system
|
|
US9452138B2
(en)
|
2012-12-28 |
2016-09-27 |
Abbott Cardiovascular Systems Inc. |
Delivery of biologic therapeutics
|
|
EP2958947B1
(en)
|
2013-02-20 |
2019-08-14 |
The University of Queensland |
Conjugate compound and uses of same
|
|
WO2014138897A1
(en)
|
2013-03-14 |
2014-09-18 |
Anacoti Ltd. |
Hyaluronic acid derivatives
|
|
WO2014154804A1
(en)
|
2013-03-27 |
2014-10-02 |
Centre Hospitalier Universitaire Vaudois (C.H.U.V) |
Pharmaceutical formulation for use in the treatment and/or prevention of restenosis
|
|
KR102049568B1
(ko)
|
2013-04-01 |
2019-11-27 |
삼성전자주식회사 |
히알루론산을 포함하는 핵산전달용 조성물
|
|
US9744260B2
(en)
|
2013-04-12 |
2017-08-29 |
Phi Nguyen |
Timing controlled in-situ cross-linking of halyuronic acid during injection
|
|
WO2014169299A1
(en)
|
2013-04-12 |
2014-10-16 |
Bui The Duy |
Temperature-release catalyst for cross-linking halyuronic acid during injection
|
|
US20150190517A1
(en)
|
2013-04-12 |
2015-07-09 |
Miba Medical Inc. |
Systems and methods for delivering cross-linked halyuronic acid into a patient
|
|
EP2988783A1
(en)
*
|
2013-04-22 |
2016-03-02 |
Ascendis Pharma A/S |
Hydrogel-linked prodrugs releasing modified drugs
|
|
EP2988755A4
(en)
|
2013-04-25 |
2016-11-30 |
Aluron Biopharma Inc |
RETICULATED HYALURONIC ACID COMPOSITIONS
|
|
US10137199B2
(en)
|
2013-05-14 |
2018-11-27 |
Biotime, Inc. |
Thiolated hyaluronan-based hydrogels cross-linked using oxidized glutathione
|
|
WO2014198406A1
(en)
|
2013-06-11 |
2014-12-18 |
Anteis S.A. |
Method for crosslinking hyaluronic acid; method for preparing an injectable hydrogel; hydrogel obtained; use of the obtained hydrogel
|
|
HK1223033A1
(zh)
|
2013-06-14 |
2017-07-21 |
Galderma S.A. |
包括交联的透明质酸和环糊精的组合物
|
|
US10077321B2
(en)
|
2013-06-28 |
2018-09-18 |
Galderma S.A. |
Method for manufacturing a shaped crosslinked hyaluronic acid product
|
|
EP3016634A2
(en)
|
2013-07-05 |
2016-05-11 |
Therakine Biodelivery GmbH |
Drug-delivery composition for topical applications and injections and ophtalmic formulations, method for manufacturing thereof, and methods for delivery a drug-delivery composition
|
|
US10738134B2
(en)
|
2013-09-27 |
2020-08-11 |
Virginia Tech Intellectual Properties, Inc. |
Cross-metathesized polysaccharide derivatives and processes for preparing them
|
|
US10040850B2
(en)
|
2013-10-08 |
2018-08-07 |
Ascendis Pharma A/S |
Protecting group comprising a purification tag
|
|
JPWO2015053282A1
(ja)
|
2013-10-08 |
2017-03-09 |
キユーピー株式会社 |
カルボキシメチル基含有修飾ヒアルロン酸および/またはその塩の架橋物およびその製造方法
|
|
WO2015053281A1
(ja)
|
2013-10-08 |
2015-04-16 |
キユーピー株式会社 |
カルボキシメチル基含有修飾ヒアルロン酸および/またはその塩の架橋物およびその製造方法
|
|
US9782345B2
(en)
|
2013-10-17 |
2017-10-10 |
Jade Therapeutics, Inc. |
Ocular composition and method
|
|
KR101459070B1
(ko)
|
2013-12-09 |
2014-11-17 |
(주) 뉴메딕 |
지속성을 갖는 히알루론산 겔 조성물
|
|
WO2015112831A1
(en)
*
|
2014-01-23 |
2015-07-30 |
Akebia Therapeutics, Inc. |
Compositions and methods for treating ocular diseases
|
|
AU2015299055C1
(en)
|
2014-08-06 |
2021-05-06 |
Ascendis Pharma A/S |
Prodrugs comprising an aminoalkyl glycine linker
|
|
WO2016073157A1
(en)
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Anti-ang2 antibodies and methods of use thereof
|
|
EP4268843B1
(en)
|
2014-11-07 |
2025-09-03 |
F. Hoffmann-La Roche Ltd |
Improved il-6 antibodies
|
|
RU2017143884A
(ru)
|
2015-05-29 |
2019-07-01 |
Альбатросс Текнолоджис Лимитед |
Сшитая гиалуроновая кислота для доставки лекарственного средства и фармацевтический препарат с ее использованием
|
|
WO2016196124A2
(en)
|
2015-05-29 |
2016-12-08 |
Ascendis Pharma Inc. |
Prodrugs comprising a pyroglutamate linker
|
|
AR105319A1
(es)
*
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
|
CN108137681B
(zh)
|
2015-09-23 |
2024-06-18 |
豪夫迈·罗氏有限公司 |
抗-vegf抗体的优化的变体
|
|
EP3386520B1
(en)
|
2015-12-09 |
2022-07-20 |
The Regents of The University of California |
Methods of treating an ocular disease or disorder
|
|
AR110299A1
(es)
|
2016-12-02 |
2019-03-13 |
Sanofi Sa |
Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico
|
|
EP3600441A1
(en)
*
|
2017-03-22 |
2020-02-05 |
Genentech, Inc. |
Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
|