|
US7803931B2
(en)
|
2004-02-12 |
2010-09-28 |
Archemix Corp. |
Aptamer therapeutics useful in the treatment of complement-related disorders
|
|
AR095196A1
(es)
|
2013-03-15 |
2015-09-30 |
Regeneron Pharma |
Medio de cultivo celular libre de suero
|
|
EA201690212A8
(ru)
|
2013-07-12 |
2016-08-31 |
Офтотек Корпорейшн |
Способы лечения или профилактики офтальмологических патологических состояний
|
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
|
US9914769B2
(en)
|
2014-07-15 |
2018-03-13 |
Kymab Limited |
Precision medicine for cholesterol treatment
|
|
GB201403775D0
(en)
|
2014-03-04 |
2014-04-16 |
Kymab Ltd |
Antibodies, uses & methods
|
|
RU2723940C2
(ru)
|
2014-03-21 |
2020-06-18 |
Экс-Боди, Инк. |
Биспецифические антигенсвязывающие полипептиды
|
|
US9840553B2
(en)
|
2014-06-28 |
2017-12-12 |
Kodiak Sciences Inc. |
Dual PDGF/VEGF antagonists
|
|
JP2017537896A
(ja)
|
2014-11-10 |
2017-12-21 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
二重特異性抗体及び眼科に使用する方法
|
|
BR112017009790A2
(pt)
|
2014-11-10 |
2017-12-19 |
Hoffmann La Roche |
anticorpos direcionados ao anti-ang2 e métodos de uso
|
|
BR112017009792A2
(pt)
*
|
2014-11-10 |
2018-02-27 |
Hoffmann La Roche |
anticorpos anti-pdgf-b e métodos de uso
|
|
AU2015345320A1
(en)
|
2014-11-10 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-IL-1beta antibodies and methods of use
|
|
US20160144025A1
(en)
*
|
2014-11-25 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and formulations for treating vascular eye diseases
|
|
EA201791768A1
(ru)
*
|
2015-02-06 |
2018-07-31 |
КАДМОН КОРПОРЕЙШН, ЭлЭлСи |
Иммуномодулирующие агенты
|
|
RU2712623C2
(ru)
*
|
2015-03-31 |
2020-01-30 |
Илдонг Фарм. Ко., Лтд. |
Фармацевтическая композиция для предотвращения и лечения заболеваний глаз, содержащая в качестве активного ингредиента белок слияния, в котором слиты проникающий в ткань пептид и препарат против фактора роста эндотелия сосудов
|
|
RU2749674C2
(ru)
|
2015-07-29 |
2021-06-16 |
Аллерган, Инк. |
Антитела против ang-2, содержащие только тяжелую цепь
|
|
TWI899515B
(zh)
|
2015-08-04 |
2025-10-01 |
美商再生元醫藥公司 |
補充牛磺酸之細胞培養基及用法
|
|
EA201891164A1
(ru)
|
2015-12-16 |
2018-11-30 |
Ридженерон Фармасьютикалз, Инк. |
Композиции и способы получения белковых микрочастиц
|
|
BR112018013407A2
(en)
|
2015-12-30 |
2018-12-18 |
Kodiak Sciences Inc. |
antibodies and conjugates thereof
|
|
TWI640536B
(zh)
|
2016-06-20 |
2018-11-11 |
克馬伯有限公司 |
抗體
|
|
CA3029332A1
(en)
*
|
2016-07-01 |
2018-01-04 |
Ludwig Institute For Cancer Research Ltd |
Methods and compositions for pdgf-cc inhibition
|
|
MX2019000935A
(es)
|
2016-08-16 |
2019-07-04 |
Regeneron Pharma |
Metodos para cuantificar anticuerpos individuales de una mezcla.
|
|
WO2018039499A1
(en)
|
2016-08-24 |
2018-03-01 |
Regeneron Pharmaceuticals, Inc. |
Host cell protein modification
|
|
US11779604B2
(en)
|
2016-11-03 |
2023-10-10 |
Kymab Limited |
Antibodies, combinations comprising antibodies, biomarkers, uses and methods
|
|
CN109021104B
(zh)
*
|
2017-06-12 |
2022-08-12 |
上海睿智化学研究有限公司 |
一种抗人血小板衍生生长因子β受体的抗体及其应用
|
|
CN114075269A
(zh)
|
2017-07-06 |
2022-02-22 |
菲仕兰坎皮纳荷兰私人有限公司 |
用于制备糖蛋白的细胞培养工艺
|
|
CN111479618B
(zh)
|
2017-12-22 |
2022-08-02 |
瑞泽恩制药公司 |
用于表征药物产品杂质的系统和方法
|
|
KR20200115485A
(ko)
|
2018-01-31 |
2020-10-07 |
리제너론 파마슈티칼스 인코포레이티드 |
약물 생성물 불순물을 특성화하기 위한 시스템 및 방법
|
|
TWI786265B
(zh)
|
2018-02-02 |
2022-12-11 |
美商再生元醫藥公司 |
用於表徵蛋白質二聚合之系統及方法
|
|
US12460270B2
(en)
|
2018-02-28 |
2025-11-04 |
Regeneron Pharmaceuticals, Inc. |
Systems and methods for identifying viral contaminants
|
|
SG11202008242XA
(en)
|
2018-03-02 |
2020-09-29 |
Kodiak Sciences Inc |
Il-6 antibodies and fusion constructs and conjugates thereof
|
|
US12253490B2
(en)
|
2018-03-19 |
2025-03-18 |
Regeneron Pharmaceuticals, Inc. |
Microchip capillary electrophoresis assays and reagents
|
|
BR112020015291B1
(pt)
|
2018-03-19 |
2023-09-26 |
Regeneron Pharmaceuticals, Inc |
Tampão de amostra de eletroforese aquoso, método para identificar contaminantes ou impurezas em uma amostra de fármaco proteico, e, kit
|
|
US12259355B2
(en)
|
2018-03-19 |
2025-03-25 |
Regeneron Pharmaceuticals, Inc. |
Microchip capillary electrophoresis assays and reagents
|
|
GB201806918D0
(en)
*
|
2018-04-27 |
2018-06-13 |
Enleofen Bio Pte Ltd |
Combination treatment for eye fibrosis
|
|
CN108586611B
(zh)
*
|
2018-04-28 |
2021-01-26 |
暨南大学 |
重组全人源抗破伤风毒素单克隆抗体
|
|
TW202016125A
(zh)
|
2018-05-10 |
2020-05-01 |
美商再生元醫藥公司 |
用於定量及調節蛋白質黏度之系統與方法
|
|
CN112218877B
(zh)
|
2018-08-27 |
2025-07-25 |
瑞泽恩制药公司 |
拉曼光谱在下游纯化中的应用
|
|
KR20210053816A
(ko)
|
2018-08-30 |
2021-05-12 |
리제너론 파마슈티칼스 인코포레이티드 |
단백질 복합체를 특성화하기 위한 방법
|
|
JP7119225B2
(ja)
*
|
2018-10-05 |
2022-08-16 |
ソウル大学校産学協力団 |
Ｐｄｇｆ受容体に対する抗体およびその用途
|
|
IL284471B2
(en)
|
2019-01-16 |
2025-01-01 |
Regeneron Pharma |
Methods for identifying free thiols in proteins
|
|
US12552866B2
(en)
|
2019-03-08 |
2026-02-17 |
Linxis B.V. |
Internalizing binding molecules targeting receptors involved in cell proliferation or in cell differentiation
|
|
WO2020225147A1
(en)
|
2019-05-03 |
2020-11-12 |
Singapore Health Services Pte. Ltd. |
Treatment and prevention of metabolic diseases
|
|
EP3969908A1
(en)
|
2019-05-13 |
2022-03-23 |
Regeneron Pharmaceuticals, Inc. |
Improved competitive ligand binding assays
|
|
KR20250051157A
(ko)
|
2019-06-05 |
2025-04-16 |
리제너론 파아마슈티컬스, 인크. |
정밀 투여량 전달을 위한 디바이스 및 방법
|
|
EP4653865A3
(en)
|
2019-09-24 |
2026-02-18 |
Regeneron Pharmaceuticals, Inc. |
Systems and methods for chromatography use and regeneration
|
|
US11912784B2
(en)
|
2019-10-10 |
2024-02-27 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
|
US12297451B1
(en)
|
2019-10-25 |
2025-05-13 |
Regeneron Pharmaceuticals, Inc. |
Cell culture medium
|
|
MX2022006236A
(es)
|
2019-11-25 |
2022-06-22 |
Regeneron Pharma |
Formulaciones de liberacion sostenida con emulsiones no acuosas.
|
|
US20230090552A1
(en)
|
2020-01-08 |
2023-03-23 |
Synthis Therapeutics, Inc. |
Alk5 inhibitor conjugates and uses thereof
|
|
KR102544013B1
(ko)
|
2020-01-21 |
2023-06-19 |
리제너론 파마슈티칼스 인코포레이티드 |
당질화된 단백질의 전기영동을 위한 탈당질화 방법
|
|
KR20220140551A
(ko)
*
|
2020-02-07 |
2022-10-18 |
바이오리온 테크놀러지스 비.브이. |
혈소판 유래 성장 인자 수용체(pdgfr) 항체, 이의 컨쥬게이트, 조성물 및 용도
|
|
CA3192999A1
(en)
|
2020-08-31 |
2022-03-03 |
Regeneron Pharmaceuticals, Inc. |
Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants
|
|
JP2023541934A
(ja)
*
|
2020-09-16 |
2023-10-04 |
リンクシス ベスローテン フェンノートシャップ |
内在化結合分子
|
|
EP4251128A1
(en)
|
2020-11-25 |
2023-10-04 |
Regeneron Pharmaceuticals, Inc. |
Sustained release formulations using non-aqueous membrane emulsification
|
|
WO2022133135A1
(en)
|
2020-12-17 |
2022-06-23 |
Regeneron Pharmaceuticals, Inc. |
Fabrication of protein-encapsulating microgels
|
|
CN116761880A
(zh)
|
2021-01-20 |
2023-09-15 |
瑞泽恩制药公司 |
改进细胞培养物中的蛋白质滴度的方法
|
|
JP2024505195A
(ja)
*
|
2021-01-25 |
2024-02-05 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
抗ｐｄｇｆ－ｂ抗体及び肺動脈高血圧症（ｐａｈ）を治療するための使用方法
|
|
CA3207883A1
(en)
|
2021-03-03 |
2022-09-09 |
Xiaobin Xu |
Systems and methods for quantifying and modifying protein viscosity
|
|
US20220309215A1
(en)
|
2021-03-26 |
2022-09-29 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for developing mixing protocols
|
|
AU2022286340A1
(en)
|
2021-06-01 |
2024-01-04 |
Regeneron Pharmaceuticals, Inc. |
Microchip capillary electrophoresis assays and reagents
|
|
WO2023039457A1
(en)
|
2021-09-08 |
2023-03-16 |
Regeneron Pharmaceuticals, Inc. |
A high-throughput and mass-spectrometry-based method for quantitating antibodies and other fc-containing proteins
|
|
AU2022348521A1
(en)
|
2021-09-20 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
Methods of controlling antibody heterogeneity
|
|
CN118076894A
(zh)
|
2021-10-07 |
2024-05-24 |
里珍纳龙药品有限公司 |
pH建模和控制的系统及方法
|
|
KR20240090312A
(ko)
|
2021-10-07 |
2024-06-21 |
리제너론 파아마슈티컬스, 인크. |
Ph 미터 보정 및 교정
|
|
KR20240097864A
(ko)
|
2021-10-26 |
2024-06-27 |
리제너론 파마슈티칼스 인코포레이티드 |
상이한 온도에서 실험실 용수를 생성하고 실험실 용수를 분배하는 시스템 및 방법
|
|
CA3245647A1
(en)
|
2022-03-18 |
2023-09-21 |
Regeneron Pharmaceuticals, Inc. |
METHODS AND SYSTEMS FOR ANALYZING POLYPEPTIDE VARIANTS
|
|
US11723955B1
(en)
|
2022-05-13 |
2023-08-15 |
Allgenesis Biotherapeutics Inc. |
VEGFR fusion protein pharmaceutical composition
|
|
TW202435942A
(zh)
|
2022-12-16 |
2024-09-16 |
美商里珍納龍藥品有限公司 |
評估層析管柱完整性的方法及系統
|
|
US20240245779A1
(en)
|
2023-01-25 |
2024-07-25 |
Regeneron Pharmaceuticals, Inc. |
Methods of modeling liquid protein composition stability
|
|
TW202445126A
(zh)
|
2023-01-25 |
2024-11-16 |
美商再生元醫藥公司 |
基於質譜法之體內共表現抗體之表徵
|
|
TW202445138A
(zh)
|
2023-02-01 |
2024-11-16 |
美商再生元醫藥公司 |
用於生物巨分子分析之具質譜法的不對稱流場流分離
|
|
WO2024178213A2
(en)
|
2023-02-22 |
2024-08-29 |
Regeneron Pharmaceuticals, Inc. |
System suitability parameters and column aging
|
|
TW202508625A
(zh)
|
2023-05-01 |
2025-03-01 |
美商再生元醫藥公司 |
使用苯酚或苯甲醇之多劑量抗體藥物產品
|
|
US20250086164A1
(en)
|
2023-09-08 |
2025-03-13 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for assessing chromatographic column integrity
|
|
WO2025064403A2
(en)
|
2023-09-18 |
2025-03-27 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for developing chromatography protocols
|
|
US20250109905A1
(en)
|
2023-09-29 |
2025-04-03 |
Regeneron Pharmaceuticals, Inc. |
Lyophilization using controlled nucleation
|
|
US20250129117A1
(en)
|
2023-10-18 |
2025-04-24 |
Regeneron Pharmaceuticals, Inc. |
Rapid purification of monoclonal antibody from in-process upstream cell culture material
|
|
US20250145662A1
(en)
|
2023-11-02 |
2025-05-08 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing lipase activity using stress
|
|
WO2025166281A1
(en)
|
2024-02-01 |
2025-08-07 |
Regeneron Pharmaceuticals, Inc. |
Platform for charge-detection mass spectrometry analysis of aavs
|
|
WO2025175164A1
(en)
|
2024-02-16 |
2025-08-21 |
Regeneron Pharmaceuticals, Inc. |
Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods
|
|
WO2025194043A1
(en)
|
2024-03-15 |
2025-09-18 |
Regeneron Pharmaceuticals, Inc. |
Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations
|
|
CN118440214B
(zh)
*
|
2024-04-02 |
2025-01-28 |
山东大学 |
一种靶向PDGFRβ的嵌合抗原受体、CAR-T细胞及应用
|
|
WO2025259840A1
(en)
|
2024-06-13 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for scaled chromatography
|
|
WO2026025028A1
(en)
|
2024-07-26 |
2026-01-29 |
Regeneron Pharmaceuticals, Inc. |
Methods of making ultra-high concentrated protein formulations using lyophilization
|