JP2017535285A5 - - Google Patents
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- JP2017535285A5 JP2017535285A5 JP2017543332A JP2017543332A JP2017535285A5 JP 2017535285 A5 JP2017535285 A5 JP 2017535285A5 JP 2017543332 A JP2017543332 A JP 2017543332A JP 2017543332 A JP2017543332 A JP 2017543332A JP 2017535285 A5 JP2017535285 A5 JP 2017535285A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- seq
- binding fragment
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims description 96
- 239000000427 antigen Substances 0.000 claims description 93
- 102000036639 antigens Human genes 0.000 claims description 93
- 108091007433 antigens Proteins 0.000 claims description 93
- 102000004889 Interleukin-6 Human genes 0.000 claims description 26
- 108090001005 Interleukin-6 Proteins 0.000 claims description 26
- 201000010099 disease Diseases 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 230000035772 mutation Effects 0.000 claims description 17
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 15
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 15
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 14
- 201000011190 diabetic macular edema Diseases 0.000 claims description 14
- 230000009885 systemic effect Effects 0.000 claims description 12
- 206010013774 Dry eye Diseases 0.000 claims description 10
- 238000009825 accumulation Methods 0.000 claims description 10
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 10
- 208000002780 macular degeneration Diseases 0.000 claims description 10
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 10
- 102000001708 Protein Isoforms Human genes 0.000 claims description 9
- 108010029485 Protein Isoforms Proteins 0.000 claims description 9
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims description 9
- 238000003556 assay Methods 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims description 5
- 206010038848 Retinal detachment Diseases 0.000 claims description 5
- 206010046851 Uveitis Diseases 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 5
- 230000007423 decrease Effects 0.000 claims description 5
- 102000052611 human IL6 Human genes 0.000 claims description 5
- 208000014674 injury Diseases 0.000 claims description 5
- 238000002054 transplantation Methods 0.000 claims description 5
- 108010081667 aflibercept Proteins 0.000 claims description 4
- 229940051306 eylea Drugs 0.000 claims description 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 4
- 229960003989 tocilizumab Drugs 0.000 claims description 4
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 3
- 208000022873 Ocular disease Diseases 0.000 claims description 3
- 208000002205 allergic conjunctivitis Diseases 0.000 claims description 3
- 208000024998 atopic conjunctivitis Diseases 0.000 claims description 3
- 238000001516 cell proliferation assay Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 230000014759 maintenance of location Effects 0.000 claims description 2
- 208000019793 rhegmatogenous retinal detachment Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 4
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000004264 retinal detachment Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462077105P | 2014-11-07 | 2014-11-07 | |
| US62/077,105 | 2014-11-07 | ||
| US201462087448P | 2014-12-04 | 2014-12-04 | |
| US62/087,448 | 2014-12-04 | ||
| US201562247705P | 2015-10-28 | 2015-10-28 | |
| US62/247,705 | 2015-10-28 | ||
| PCT/US2015/059532 WO2016073890A1 (en) | 2014-11-07 | 2015-11-06 | Improved il-6 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535285A JP2017535285A (ja) | 2017-11-30 |
| JP2017535285A5 true JP2017535285A5 (enExample) | 2018-12-13 |
| JP6594438B2 JP6594438B2 (ja) | 2019-10-23 |
Family
ID=54602042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017543332A Active JP6594438B2 (ja) | 2014-11-07 | 2015-11-06 | 改善されたｉｌ−６抗体 |
Country Status (33)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10072075B2 (en) | 2015-09-23 | 2018-09-11 | Genentech, Inc. | Optimized variants of anti-VEGF antibodies and methods of treatment thereof by reducing or inhibiting angiogenesis |
| US20190046642A1 (en) * | 2016-02-23 | 2019-02-14 | Eleven Biotherapeutics, Inc. | Il-6 antagonist formulations and uses thereof |
| CN110291108A (zh) * | 2016-12-19 | 2019-09-27 | 格兰马克药品股份有限公司 | 新型tnfr激动剂及其用途 |
| PE20191758A1 (es) | 2017-03-22 | 2019-12-12 | Genentech Inc | Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares |
| AR111190A1 (es) | 2017-03-22 | 2019-06-12 | Genentech Inc | Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados |
| CN109867723B (zh) * | 2017-12-05 | 2022-06-17 | 南京金斯瑞生物科技有限公司 | 抗人il6单克隆抗体及其制备方法和用途 |
| TW202144410A (zh) | 2020-03-13 | 2021-12-01 | 美商建南德克公司 | 抗介白素－３３抗體及其用途 |
| CR20220489A (es) | 2020-03-24 | 2022-10-31 | Genentech Inc | Agentes de fijación a tie2 y métodos de uso. |
| WO2022079161A1 (en) | 2020-10-15 | 2022-04-21 | F. Hoffmann-La Roche Ag | Non-covalent protein-hyaluronan conjugates for long-acting ocular delivery |
| CN116355825A (zh) * | 2022-02-25 | 2023-06-30 | 南京工业大学 | 一种强化纤维素合成来提高人表皮生长因子分泌生产效率的方法 |
| CN115343483B (zh) * | 2022-08-12 | 2024-11-26 | 苏州邦器生物技术有限公司 | 一种自身免疫性糖尿病检测用试剂盒及其制备方法 |
| CA3264497A1 (en) * | 2022-10-24 | 2024-05-02 | F. Hoffmann-La Roche Ag | Predicting response to il-6 antagonists |
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| BR112015008186A2 (pt) | 2012-10-25 | 2017-09-19 | Medimmune Llc | formulação de um anticorpo estável e de baixa viscosidade |
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| SG10201708882TA (en) | 2013-07-12 | 2017-12-28 | Ophthotech Corp | Methods for treating or preventing ophthalmological conditions |
| WO2016073894A1 (en) | 2014-11-07 | 2016-05-12 | Eleven Biotherapeutics, Inc. | Therapeutic agents with increased ocular retention |
-
2015
- 2015-11-06 PH PH1/2017/500809A patent/PH12017500809B1/en unknown
- 2015-11-06 MY MYPI2017000609A patent/MY185114A/en unknown
- 2015-11-06 FI FIEP23189385.0T patent/FI4268843T3/fi active
- 2015-11-06 HU HUE15797538A patent/HUE046181T2/hu unknown
- 2015-11-06 PE PE2017000804A patent/PE20171107A1/es unknown
- 2015-11-06 SG SG11201703574VA patent/SG11201703574VA/en unknown
- 2015-11-06 JP JP2017543332A patent/JP6594438B2/ja active Active
- 2015-11-06 RS RS20251073A patent/RS67353B1/sr unknown
- 2015-11-06 ES ES15797538T patent/ES2756275T3/es active Active
- 2015-11-06 DK DK15797538T patent/DK3215530T3/da active
- 2015-11-06 HR HRP20191945TT patent/HRP20191945T1/hr unknown
- 2015-11-06 ES ES23189385T patent/ES3051832T3/es active Active
- 2015-11-06 SI SI201530995T patent/SI3215530T1/sl unknown
- 2015-11-06 WO PCT/US2015/059532 patent/WO2016073890A1/en not_active Ceased
- 2015-11-06 UA UAA201705592A patent/UA122673C2/uk unknown
- 2015-11-06 CN CN201580065652.6A patent/CN107249631B/zh active Active
- 2015-11-06 LT LTEP23189385.0T patent/LT4268843T/lt unknown
- 2015-11-06 PL PL15797538T patent/PL3215530T3/pl unknown
- 2015-11-06 EP EP15797538.4A patent/EP3215530B9/en active Active
- 2015-11-06 US US15/524,727 patent/US11142571B2/en active Active
- 2015-11-06 SG SG10202103420PA patent/SG10202103420PA/en unknown
- 2015-11-06 AU AU2015342882A patent/AU2015342882B2/en active Active
- 2015-11-06 KR KR1020247004699A patent/KR102770849B1/ko active Active
- 2015-11-06 IL IL251858A patent/IL251858B/en unknown
- 2015-11-06 SM SM20250415T patent/SMT202500415T1/it unknown
- 2015-11-06 PT PT157975384T patent/PT3215530T/pt unknown
- 2015-11-06 KR KR1020177014412A patent/KR102636726B1/ko active Active
- 2015-11-06 DK DK23189385.0T patent/DK4268843T3/da active
- 2015-11-06 RS RS20191447A patent/RS59805B1/sr unknown
- 2015-11-06 EP EP23189385.0A patent/EP4268843B1/en active Active
- 2015-11-06 CR CR20170231A patent/CR20170231A/es unknown
- 2015-11-06 EP EP19189890.7A patent/EP3632931A1/en active Pending
- 2015-11-06 MA MA62787A patent/MA62787B1/fr unknown
- 2015-11-06 EA EA201791005A patent/EA035199B1/ru not_active IP Right Cessation
- 2015-11-06 MA MA051554A patent/MA51554A/fr unknown
- 2015-11-06 MX MX2017005992A patent/MX385206B/es unknown
- 2015-11-06 PT PT231893850T patent/PT4268843T/pt unknown
- 2015-11-06 PL PL23189385.0T patent/PL4268843T3/pl unknown
- 2015-11-06 CA CA2965689A patent/CA2965689C/en active Active
- 2015-11-06 HR HRP20251312TT patent/HRP20251312T1/hr unknown
-
2017
- 2017-04-28 ZA ZA201702985A patent/ZA201702985B/en unknown
- 2017-05-03 SA SA517381458A patent/SA517381458B1/ar unknown
- 2017-05-05 CL CL2017001135A patent/CL2017001135A1/es unknown
- 2017-05-08 MX MX2021008663A patent/MX2021008663A/es unknown
- 2017-05-30 CO CONC2017/0005404A patent/CO2017005404A2/es unknown
-
2021
- 2021-09-13 US US17/473,696 patent/US20220169719A1/en not_active Abandoned
-
2024
- 2024-05-13 US US18/662,445 patent/US20250059270A1/en active Pending
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