JP2011503094A5 - - Google Patents

Info

Publication number

JP2011503094A5

JP2011503094A5 JP2010533241A JP2010533241A JP2011503094A5 JP 2011503094 A5 JP2011503094 A5 JP 2011503094A5 JP 2010533241 A JP2010533241 A JP 2010533241A JP 2010533241 A JP2010533241 A JP 2010533241A JP 2011503094 A5 JP2011503094 A5 JP 2011503094A5

Authority

JP

Japan

Prior art keywords

antibody

factor

composition

fragment

seq

Prior art date

2008-11-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 32
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 32
• 102000003712 Complement factor B Human genes 0.000 claims description 16
• 108090000056 Complement factor B Proteins 0.000 claims description 16
• 239000005557 antagonist Substances 0.000 claims description 15
• 230000000295 complement effect Effects 0.000 claims description 15
• 206010064930 age-related macular degeneration Diseases 0.000 claims description 14
• 208000002780 macular degeneration Diseases 0.000 claims description 14
• 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 10
• 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 10
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims description 8
• 201000005667 central retinal vein occlusion Diseases 0.000 claims description 8
• 239000012634 fragment Substances 0.000 claims description 8
• 208000004644 retinal vein occlusion Diseases 0.000 claims description 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 206010055665 Corneal neovascularisation Diseases 0.000 claims description 4
• 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 4
• 201000002563 Histoplasmosis Diseases 0.000 claims description 4
• 208000007135 Retinal Neovascularization Diseases 0.000 claims description 4
• 208000017442 Retinal disease Diseases 0.000 claims description 4
• 206010038923 Retinopathy Diseases 0.000 claims description 4
• 206010046851 Uveitis Diseases 0.000 claims description 4
• 201000000159 corneal neovascularization Diseases 0.000 claims description 4
• 208000001309 degenerative myopia Diseases 0.000 claims description 4
• 230000004340 degenerative myopia Effects 0.000 claims description 4
• 206010012601 diabetes mellitus Diseases 0.000 claims description 4
• 201000011190 diabetic macular edema Diseases 0.000 claims description 4
• 208000028867 ischemia Diseases 0.000 claims description 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
• 208000006542 von Hippel-Lindau disease Diseases 0.000 claims description 4
• 241000124008 Mammalia Species 0.000 claims description 2
• 208000000208 Wet Macular Degeneration Diseases 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims description 2
• 208000011325 dry age related macular degeneration Diseases 0.000 claims description 2
• 229920001184 polypeptide Polymers 0.000 claims description 2
• 230000002265 prevention Effects 0.000 claims description 2
• 150000003384 small molecules Chemical class 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 18
• 238000000034 method Methods 0.000 description 17