JP2014532072A5 - - Google Patents
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- Publication number
- JP2014532072A5 JP2014532072A5 JP2014535978A JP2014535978A JP2014532072A5 JP 2014532072 A5 JP2014532072 A5 JP 2014532072A5 JP 2014535978 A JP2014535978 A JP 2014535978A JP 2014535978 A JP2014535978 A JP 2014535978A JP 2014532072 A5 JP2014532072 A5 JP 2014532072A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- monoclonal antibody
- antigen
- binding fragment
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161546708P | 2011-10-13 | 2011-10-13 | |
| US61/546,708 | 2011-10-13 | ||
| PCT/US2012/060263 WO2013056233A1 (en) | 2011-10-13 | 2012-10-15 | Treatment of ocular disease |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016178593A Division JP2016210812A (ja) | 2011-10-13 | 2016-09-13 | 眼疾患の治療 |
| JP2016178592A Division JP6259503B2 (ja) | 2011-10-13 | 2016-09-13 | 眼疾患の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014532072A JP2014532072A (ja) | 2014-12-04 |
| JP2014532072A5 true JP2014532072A5 (enExample) | 2015-12-24 |
Family
ID=48082580
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535978A Withdrawn JP2014532072A (ja) | 2011-10-13 | 2012-10-15 | 眼疾患の治療 |
| JP2016178592A Active JP6259503B2 (ja) | 2011-10-13 | 2016-09-13 | 眼疾患の治療 |
| JP2016178593A Withdrawn JP2016210812A (ja) | 2011-10-13 | 2016-09-13 | 眼疾患の治療 |
| JP2018103593A Pending JP2018131467A (ja) | 2011-10-13 | 2018-05-30 | 眼疾患の治療 |
| JP2018103592A Pending JP2018131466A (ja) | 2011-10-13 | 2018-05-30 | 眼疾患の治療 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016178592A Active JP6259503B2 (ja) | 2011-10-13 | 2016-09-13 | 眼疾患の治療 |
| JP2016178593A Withdrawn JP2016210812A (ja) | 2011-10-13 | 2016-09-13 | 眼疾患の治療 |
| JP2018103593A Pending JP2018131467A (ja) | 2011-10-13 | 2018-05-30 | 眼疾患の治療 |
| JP2018103592A Pending JP2018131466A (ja) | 2011-10-13 | 2018-05-30 | 眼疾患の治療 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8999325B2 (enExample) |
| EP (2) | EP3501536B1 (enExample) |
| JP (5) | JP2014532072A (enExample) |
| CN (2) | CN104066448A (enExample) |
| AU (1) | AU2012323849B2 (enExample) |
| BR (1) | BR112014008759A8 (enExample) |
| CA (1) | CA2850824C (enExample) |
| ES (1) | ES2774972T3 (enExample) |
| HK (2) | HK1201196A1 (enExample) |
| MX (1) | MX347226B (enExample) |
| WO (1) | WO2013056233A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3252079B8 (en) | 2006-04-07 | 2020-09-09 | Aerpio Therapeutics LLC | Antibodies that bind human protein tyrosine phosphatase beta (hptp-beta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| SG10201505672TA (en) | 2009-07-06 | 2015-09-29 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| MY160066A (en) | 2009-11-06 | 2017-02-15 | Aerpio Therapeutics Inc | Methods for increasing the stabilization of hypoxia inducible factor-1 alpha |
| CN104039351A (zh) | 2011-10-13 | 2014-09-10 | 阿尔皮奥治疗学股份有限公司 | 用于治疗血管渗漏综合征和癌症的方法 |
| CA2850824C (en) | 2011-10-13 | 2023-01-03 | Aerpio Therapeutics, Inc. | Treatment of ocular disease |
| ES2928162T3 (es) | 2013-03-15 | 2022-11-15 | Eyepoint Pharmaceuticals Inc | Composiciones, formulaciones y métodos para tratar enfermedades oculares |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| US20160068613A1 (en) | 2013-04-29 | 2016-03-10 | Hoffmann-La Roche Inc. | Fc-receptor binding modified asymmetric antibodies and methods of use |
| CA2932364A1 (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with improved protein a-binding |
| CA2931979A1 (en) * | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn-binding properties |
| EP3107542B1 (en) | 2014-02-19 | 2019-05-01 | Aerpio Therapeutics, Inc. | Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones |
| EP3116503A4 (en) | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| US9539245B2 (en) | 2014-08-07 | 2017-01-10 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of Tie-2 |
| US20160082129A1 (en) * | 2014-09-24 | 2016-03-24 | Aerpio Therapeutics, Inc. | VE-PTP Extracellular Domain Antibodies Delivered by a Gene Therapy Vector |
| EP3352856B1 (en) | 2015-09-23 | 2021-08-18 | Aerpio Pharmaceuticals, Inc. | Activators of tie-2 for use in treating intraocular pressure |
| WO2018017714A1 (en) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
| CN109996440A (zh) * | 2016-10-21 | 2019-07-09 | 曼宁研究有限公司 | Ve-ptp敲除 |
| CN106491911A (zh) * | 2016-10-24 | 2017-03-15 | 严成 | 一种治疗脉络膜血管瘤的中药 |
| CN120058958A (zh) | 2018-09-24 | 2025-05-30 | 视点制药公司 | 靶向HPTP-β（VE-PTP）和VEGF的多特异性抗体 |
| KR102467349B1 (ko) | 2018-10-29 | 2022-11-16 | 에프. 호프만-라 로슈 아게 | 항체 제형 |
| US11253502B2 (en) | 2019-04-29 | 2022-02-22 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the Schlemm's canal |
| US11413242B2 (en) | 2019-06-24 | 2022-08-16 | EyePoint Pharmaceuticals, Inc. | Formulations of Tie-2 activators and methods of use thereof |
| CN119303075A (zh) * | 2019-08-06 | 2025-01-14 | 豪夫迈·罗氏有限公司 | 眼科疾病的个性化治疗 |
| CN112322719A (zh) * | 2020-11-06 | 2021-02-05 | 温州医科大学 | 循环血外泌体miRNA作为视网膜静脉阻塞疾病诊断标志物中的应用 |
| WO2025014308A1 (ko) * | 2023-07-11 | 2025-01-16 | 재단법인 아산사회복지재단 | Tie2을 과발현하는 혈관내피세포를 포함하는 망막 내 혈관신생 질환 예방 또는 치료용 조성물 |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
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| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
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| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
| US5625825A (en) | 1993-10-21 | 1997-04-29 | Lsi Logic Corporation | Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network |
| US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
| KR100870353B1 (ko) * | 1997-04-07 | 2008-11-25 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
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| EP1046715A1 (en) * | 1999-04-23 | 2000-10-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2 |
| WO2001097850A2 (en) | 2000-06-23 | 2001-12-27 | Schering Aktiengesellschaft | Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii) |
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| US20040254197A1 (en) * | 2001-09-28 | 2004-12-16 | Santen Pharmaceutical Co., Ltd. | Injections for eye tissues containing drug bonded to polyethlene glycol |
| US20030158083A1 (en) * | 2002-02-08 | 2003-08-21 | The Procter & Gamble Company | Method of effecting angiogenesis by modulating the function of a novel endothelia phosphatase |
| US7507568B2 (en) | 2002-09-25 | 2009-03-24 | The Proctor & Gamble Company | Three dimensional coordinates of HPTPbeta |
| US7226755B1 (en) | 2002-09-25 | 2007-06-05 | The Procter & Gamble Company | HPTPbeta as a target in treatment of angiogenesis mediated disorders |
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| WO2006068953A2 (en) | 2004-12-21 | 2006-06-29 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
| JP2006210811A (ja) * | 2005-01-31 | 2006-08-10 | Nippon Steel Chem Co Ltd | プリント配線板の製造方法 |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| WO2007033216A2 (en) | 2005-09-12 | 2007-03-22 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state |
| EP1962903B1 (en) | 2005-12-15 | 2013-03-13 | MedImmune Limited | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer |
| EP3252079B8 (en) * | 2006-04-07 | 2020-09-09 | Aerpio Therapeutics LLC | Antibodies that bind human protein tyrosine phosphatase beta (hptp-beta) and uses thereof |
| US8846685B2 (en) | 2006-06-27 | 2014-09-30 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
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| US9096555B2 (en) | 2009-01-12 | 2015-08-04 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome |
| US8883832B2 (en) | 2009-07-06 | 2014-11-11 | Aerpio Therapeutics Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| SG10201505672TA (en) | 2009-07-06 | 2015-09-29 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| KR101823924B1 (ko) | 2010-10-07 | 2018-01-31 | 에르피오 세러퓨틱스 인코포레이티드 | 안구 부종, 신생혈관화 및 관련 질환의 치료를 위한 조성물 및 방법 |
| US20180092883A1 (en) | 2010-10-07 | 2018-04-05 | Aerpio Therapeutics, Inc. | Phosphatase inhibitors for treating ocular diseases |
| CA2850824C (en) | 2011-10-13 | 2023-01-03 | Aerpio Therapeutics, Inc. | Treatment of ocular disease |
| CN104039351A (zh) | 2011-10-13 | 2014-09-10 | 阿尔皮奥治疗学股份有限公司 | 用于治疗血管渗漏综合征和癌症的方法 |
| ES2928162T3 (es) | 2013-03-15 | 2022-11-15 | Eyepoint Pharmaceuticals Inc | Composiciones, formulaciones y métodos para tratar enfermedades oculares |
| WO2018017714A1 (en) * | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
| CN120058958A (zh) * | 2018-09-24 | 2025-05-30 | 视点制药公司 | 靶向HPTP-β（VE-PTP）和VEGF的多特异性抗体 |
-
2012
- 2012-10-15 CA CA2850824A patent/CA2850824C/en active Active
- 2012-10-15 US US13/652,154 patent/US8999325B2/en active Active
- 2012-10-15 CN CN201280054482.8A patent/CN104066448A/zh active Pending
- 2012-10-15 MX MX2014004449A patent/MX347226B/es active IP Right Grant
- 2012-10-15 HK HK15101784.1A patent/HK1201196A1/xx unknown
- 2012-10-15 BR BR112014008759A patent/BR112014008759A8/pt not_active Application Discontinuation
- 2012-10-15 ES ES12840725T patent/ES2774972T3/es active Active
- 2012-10-15 WO PCT/US2012/060263 patent/WO2013056233A1/en not_active Ceased
- 2012-10-15 CN CN201710084072.2A patent/CN107080843A/zh active Pending
- 2012-10-15 EP EP18202143.6A patent/EP3501536B1/en active Active
- 2012-10-15 AU AU2012323849A patent/AU2012323849B2/en active Active
- 2012-10-15 JP JP2014535978A patent/JP2014532072A/ja not_active Withdrawn
- 2012-10-15 HK HK15101828.9A patent/HK1201438A1/xx unknown
- 2012-10-15 EP EP12840725.1A patent/EP2766044B1/en active Active
-
2015
- 2015-02-20 US US14/627,463 patent/US20150232575A1/en not_active Abandoned
-
2016
- 2016-09-13 JP JP2016178592A patent/JP6259503B2/ja active Active
- 2016-09-13 JP JP2016178593A patent/JP2016210812A/ja not_active Withdrawn
-
2017
- 2017-03-20 US US15/463,340 patent/US10329357B2/en active Active
-
2018
- 2018-05-30 JP JP2018103593A patent/JP2018131467A/ja active Pending
- 2018-05-30 JP JP2018103592A patent/JP2018131466A/ja active Pending
-
2019
- 2019-04-26 US US16/395,972 patent/US20200010565A1/en not_active Abandoned
-
2020
- 2020-01-24 US US16/751,824 patent/US20200231703A1/en not_active Abandoned
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