CN107080843A - 眼病的治疗 - Google Patents

眼病的治疗 Download PDF

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Publication number
CN107080843A
CN107080843A CN201710084072.2A CN201710084072A CN107080843A CN 107080843 A CN107080843 A CN 107080843A CN 201710084072 A CN201710084072 A CN 201710084072A CN 107080843 A CN107080843 A CN 107080843A
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CN
China
Prior art keywords
ser
val
leu
thr
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201710084072.2A
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English (en)
Chinese (zh)
Inventor
K·彼得斯
R·沙尔维茨
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Akebia Therapeutics Inc
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Akebia Therapeutics Inc
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Filing date
Publication date
Application filed by Akebia Therapeutics Inc filed Critical Akebia Therapeutics Inc
Publication of CN107080843A publication Critical patent/CN107080843A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201710084072.2A 2011-10-13 2012-10-15 眼病的治疗 Pending CN107080843A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161546708P 2011-10-13 2011-10-13
US61/546,708 2011-10-13
CN201280054482.8A CN104066448A (zh) 2011-10-13 2012-10-15 眼病的治疗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280054482.8A Division CN104066448A (zh) 2011-10-13 2012-10-15 眼病的治疗

Publications (1)

Publication Number Publication Date
CN107080843A true CN107080843A (zh) 2017-08-22

Family

ID=48082580

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201280054482.8A Pending CN104066448A (zh) 2011-10-13 2012-10-15 眼病的治疗
CN201710084072.2A Pending CN107080843A (zh) 2011-10-13 2012-10-15 眼病的治疗

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201280054482.8A Pending CN104066448A (zh) 2011-10-13 2012-10-15 眼病的治疗

Country Status (11)

Country Link
US (5) US8999325B2 (enExample)
EP (2) EP3501536B1 (enExample)
JP (5) JP2014532072A (enExample)
CN (2) CN104066448A (enExample)
AU (1) AU2012323849B2 (enExample)
BR (1) BR112014008759A8 (enExample)
CA (1) CA2850824C (enExample)
ES (1) ES2774972T3 (enExample)
HK (2) HK1201196A1 (enExample)
MX (1) MX347226B (enExample)
WO (1) WO2013056233A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114341177A (zh) * 2019-08-06 2022-04-12 豪夫迈·罗氏有限公司 眼科疾病的个性化治疗

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CN102638983B (zh) 2009-11-06 2014-11-26 阿尔皮奥治疗学股份有限公司 用于治疗结肠炎的组合物和方法
ES2774972T3 (es) 2011-10-13 2020-07-23 Aerpio Therapeutics Inc Tratamiento de enfermedades oculares
US20130095065A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for Treating Vascular Leak Syndrome and Cancer
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
GB2516561B (en) 2013-03-15 2016-03-09 Aerpio Therapeutics Inc Compositions, formulations and methods for treating ocular diseases
US20160068613A1 (en) 2013-04-29 2016-03-10 Hoffmann-La Roche Inc. Fc-receptor binding modified asymmetric antibodies and methods of use
MX380658B (es) 2014-01-15 2025-03-11 Hoffmann La Roche Variantes de region fc con union mejorada de la proteina a.
CN105873948B (zh) * 2014-01-15 2021-04-13 豪夫迈·罗氏有限公司 具有修饰的FCRN结合性质的Fc区变体
JP6549140B2 (ja) 2014-02-19 2019-07-24 エアーピオ セラピューティクス インコーポレイテッド Ｎ−ベンジル−３−ヒドロキシ−４−置換ピリジン−２−（１ｈ）−オン
CN106456614A (zh) 2014-03-14 2017-02-22 爱尔皮奥治疗有限公司 HPTP‑β抑制剂
US9539245B2 (en) 2014-08-07 2017-01-10 Aerpio Therapeutics, Inc. Combination of immunotherapies with activators of Tie-2
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CN109996440A (zh) * 2016-10-21 2019-07-09 曼宁研究有限公司 Ve-ptp敲除
CN106491911A (zh) * 2016-10-24 2017-03-15 严成 一种治疗脉络膜血管瘤的中药
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CN112322719A (zh) * 2020-11-06 2021-02-05 温州医科大学 循环血外泌体miRNA作为视网膜静脉阻塞疾病诊断标志物中的应用
KR20250010199A (ko) * 2023-07-11 2025-01-21 재단법인 아산사회복지재단 Tie2을 과발현하는 혈관내피세포를 포함하는 망막 내 혈관신생 질환 예방 또는 치료용 조성물

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US20130095105A1 (en) 2013-04-18
JP2018131467A (ja) 2018-08-23
AU2012323849B2 (en) 2017-04-20
HK1201438A1 (en) 2015-09-04
CN104066448A (zh) 2014-09-24
EP2766044A4 (en) 2015-06-10
ES2774972T3 (es) 2020-07-23
JP6259503B2 (ja) 2018-01-10
JP2016210811A (ja) 2016-12-15
MX2014004449A (es) 2014-11-10
US20150232575A1 (en) 2015-08-20
CA2850824C (en) 2023-01-03
US10329357B2 (en) 2019-06-25
BR112014008759A2 (pt) 2017-06-13
AU2012323849A1 (en) 2014-04-17
EP3501536A1 (en) 2019-06-26
HK1201196A1 (en) 2015-08-28
WO2013056233A1 (en) 2013-04-18
US20200231703A1 (en) 2020-07-23
JP2018131466A (ja) 2018-08-23
EP2766044B1 (en) 2019-12-11
US20180044432A1 (en) 2018-02-15
US20200010565A1 (en) 2020-01-09
NZ623275A (en) 2016-05-27
MX347226B (es) 2017-04-19
EP2766044A1 (en) 2014-08-20
JP2014532072A (ja) 2014-12-04
US8999325B2 (en) 2015-04-07
CA2850824A1 (en) 2013-04-18
BR112014008759A8 (pt) 2017-09-12
EP3501536B1 (en) 2025-12-24
JP2016210812A (ja) 2016-12-15

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