|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4548990A
(en)
|
1983-08-15 |
1985-10-22 |
Ciba-Geigy Corporation |
Crosslinked, porous polymers for controlled drug delivery
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5476996A
(en)
|
1988-06-14 |
1995-12-19 |
Lidak Pharmaceuticals |
Human immune system in non-human animal
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
ES2284161T3
(es)
|
1990-01-12 |
2007-11-01 |
Amgen Fremont Inc. |
Generacion de anticuerpos xenogenicos.
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
CA2109602C
(en)
|
1990-07-10 |
2002-10-01 |
Gregory P. Winter |
Methods for producing members of specific binding pairs
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ES2113940T3
(es)
|
1990-12-03 |
1998-05-16 |
Genentech Inc |
Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
|
|
DE69233769D1
(de)
|
1991-03-01 |
2009-09-24 |
Dyax Corp |
Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
|
|
AU662148B2
(en)
|
1991-04-10 |
1995-08-24 |
Scripps Research Institute, The |
Heterodimeric receptor libraries using phagemids
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
DE69233528T2
(de)
|
1991-11-25 |
2006-03-16 |
Enzon, Inc. |
Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
|
|
AU3328493A
(en)
|
1991-12-17 |
1993-07-19 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
JP3720353B2
(ja)
|
1992-12-04 |
2005-11-24 |
メディカル リサーチ カウンシル |
多価および多重特異性の結合タンパク質、それらの製造および使用
|
|
AU6819494A
(en)
|
1993-04-26 |
1994-11-21 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
FR2734739B1
(fr)
|
1995-06-01 |
1997-07-11 |
Gec Alsthom Stein Ind |
Dispositif de surveillance d'un broyeur a boulets
|
|
EP0795743A3
(en)
|
1996-03-15 |
1998-02-25 |
Japan Tobacco Inc. |
Method and apparatus for infra-red moisture measurement
|
|
US5839430A
(en)
|
1996-04-26 |
1998-11-24 |
Cama; Joseph |
Combination inhaler and peak flow rate meter
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
DK0979281T3
(da)
|
1997-05-02 |
2005-11-21 |
Genentech Inc |
Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele
|
|
JP3614866B2
(ja)
|
1997-06-12 |
2005-01-26 |
リサーチ コーポレイション テクノロジーズ,インコーポレイティド |
人工抗体ポリペプチド
|
|
US6358058B1
(en)
|
1998-01-30 |
2002-03-19 |
1263152 Ontario Inc. |
Aerosol dispensing inhaler training device
|
|
EP1137941B2
(en)
|
1998-12-10 |
2013-09-11 |
Bristol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
CN102766210B
(zh)
|
1999-08-24 |
2015-07-08 |
E.R.施贵宝&圣斯有限责任公司 |
人ctla-4抗体及其应用
|
|
IL155977A0
(en)
|
2000-11-30 |
2003-12-23 |
Medarex Inc |
Transgenic transchromosomal rodents for making human antibodies
|
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
|
JP4369662B2
(ja)
|
2001-04-26 |
2009-11-25 |
アビディア インコーポレイテッド |
単量体ドメインのコンビナトリアルライブラリー
|
|
ES2392073T3
(es)
*
|
2001-11-08 |
2012-12-04 |
Abbott Biotherapeutics Corp. |
Formulación farmacéutica líquida estable de anticuerpos IGG
|
|
CN1658836A
(zh)
|
2002-05-07 |
2005-08-24 |
控制传输系统公司 |
形成药物传递装置的方法
|
|
WO2004045507A2
(en)
|
2002-11-15 |
2004-06-03 |
Centocor, Inc. |
Anti-angiogenic uses of il-6 antagonists
|
|
US20040191243A1
(en)
*
|
2002-12-13 |
2004-09-30 |
Bei Chen |
System and method for stabilizing antibodies with histidine
|
|
AU2004308482A1
(en)
|
2003-12-23 |
2005-07-14 |
Rinat Neuroscience Corp. |
Agonist anti-trkC antibodies and methods using same
|
|
EA012464B1
(ru)
|
2004-08-04 |
2009-10-30 |
Эпплайд Молекьюлар Эволюшн, Инк. |
Антитело против cd20 и его применение
|
|
CA2577082A1
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
EA200870130A1
(ru)
|
2005-12-30 |
2009-02-27 |
Мерк Патент Гмбх |
Антитела против ил-6, предотвращающие связывание с gp130 комплекса ил-6 и альфа-рецептора ил-6
|
|
EP2004690A2
(en)
|
2006-03-13 |
2008-12-24 |
Ablynx N.V. |
Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
CN101600793B
(zh)
|
2006-05-19 |
2013-06-26 |
奥尔德生物制药公司 |
用于获得抗原特异性b细胞的克隆群体的培养方法
|
|
CN101605532A
(zh)
|
2007-02-16 |
2009-12-16 |
惠氏公司 |
含有山梨糖醇的蛋白质调配物
|
|
CN101754772B
(zh)
|
2007-05-21 |
2015-08-19 |
奥尔德生物控股有限责任公司 |
针对il-6的抗体及其用途
|
|
EP2198007B1
(en)
*
|
2007-09-14 |
2017-10-25 |
Sanofi Pasteur Biologics, LLC |
Pharmaceutical compositions containing clostridium difficile toxoids a and b
|
|
WO2009070243A2
(en)
|
2007-11-21 |
2009-06-04 |
Amgen Inc. |
Wise binding agents and epitopes
|
|
US20100187601A1
(en)
|
2007-12-12 |
2010-07-29 |
Fujio Masuoka |
Semiconductor device
|
|
EP2249809A1
(en)
|
2008-01-15 |
2010-11-17 |
Abbott GmbH & Co. KG |
Powdered protein compositions and methods of making same
|
|
PY09026846A
(es)
|
2008-08-05 |
2015-09-01 |
Novartis Ag |
Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
|
|
CN102123796B
(zh)
|
2008-09-12 |
2013-09-11 |
Kdf株式会社 |
喷水装置
|
|
US20120005773A1
(en)
*
|
2008-10-01 |
2012-01-05 |
Aasen Eric D |
Transgenic plants with enhanced agronomic traits
|
|
US8992920B2
(en)
*
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
KR20110091777A
(ko)
|
2008-11-26 |
2011-08-12 |
글락소 그룹 리미티드 |
폴리펩티드, 항체 가변 도메인 및 길항제
|
|
CA2749200A1
(en)
*
|
2009-01-29 |
2010-08-05 |
Michael Bowen |
Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases
|
|
JO3417B1
(ar)
*
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
JP5913307B2
(ja)
|
2010-07-12 |
2016-04-27 |
コヴェックス・テクノロジーズ・アイルランド・リミテッド |
多機能性抗体複合体
|
|
AU2012347545A1
(en)
|
2011-12-07 |
2014-06-12 |
Amgen Inc. |
IgG2 disulfide isoform separation
|
|
EA201492289A1
(ru)
*
|
2012-06-01 |
2015-05-29 |
Офтотек Корпорейшн |
Композиции, содержащие аптамер против pdgf и антагонист vegf
|
|
LT3495387T
(lt)
|
2012-07-13 |
2021-11-25 |
Roche Glycart Ag |
Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti
|
|
MX2015003007A
(es)
*
|
2012-09-07 |
2015-06-05 |
Coherus Biosciences Inc |
Formulaciones acuosas estables de adalimumab.
|
|
CN104768578A
(zh)
*
|
2012-10-25 |
2015-07-08 |
米迪缪尼有限公司 |
稳定的低粘度抗体配制品
|
|
EP2917238A1
(en)
*
|
2012-11-08 |
2015-09-16 |
Eleven Biotherapeutics, Inc. |
Il-6 antagonists and uses thereof
|
|
KR102948178B1
(ko)
*
|
2013-07-12 |
2026-04-10 |
아스텔라스 유에스 엘엘씨 |
안과적 질환을 치료하거나 예방하기 위한 방법
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
US11142571B2
(en)
*
|
2014-11-07 |
2021-10-12 |
Sesen Bio, Inc. |
IL-6 antibodies
|
|
WO2016073894A1
(en)
|
2014-11-07 |
2016-05-12 |
Eleven Biotherapeutics, Inc. |
Therapeutic agents with increased ocular retention
|