|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4548990A
(en)
|
1983-08-15 |
1985-10-22 |
Ciba-Geigy Corporation |
Crosslinked, porous polymers for controlled drug delivery
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5476996A
(en)
|
1988-06-14 |
1995-12-19 |
Lidak Pharmaceuticals |
Human immune system in non-human animal
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
CA2095633C
(en)
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
EP1820858B1
(en)
|
1991-03-01 |
2009-08-12 |
Dyax Corporation |
Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
ATE207080T1
(de)
|
1991-11-25 |
2001-11-15 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
ES2156149T3
(es)
|
1992-12-04 |
2001-06-16 |
Medical Res Council |
Proteinas de union multivalente y multiespecificas, su fabricacion y su uso.
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
FR2734739B1
(fr)
|
1995-06-01 |
1997-07-11 |
Gec Alsthom Stein Ind |
Dispositif de surveillance d'un broyeur a boulets
|
|
EP0795743A3
(en)
|
1996-03-15 |
1998-02-25 |
Japan Tobacco Inc. |
Method and apparatus for infra-red moisture measurement
|
|
US5839430A
(en)
|
1996-04-26 |
1998-11-24 |
Cama; Joseph |
Combination inhaler and peak flow rate meter
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
ATE299938T1
(de)
|
1997-05-02 |
2005-08-15 |
Genentech Inc |
Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
|
EP1958962A3
(en)
|
1997-06-12 |
2013-05-01 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
US6358058B1
(en)
|
1998-01-30 |
2002-03-19 |
1263152 Ontario Inc. |
Aerosol dispensing inhaler training device
|
|
DK1137941T4
(da)
|
1998-12-10 |
2014-01-06 |
Brystol Myers Squibb Company |
Protein-scaffolds til antistof-mimetika og andre bindingsproteiner
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
CA2430013C
(en)
|
2000-11-30 |
2011-11-22 |
Medarex, Inc. |
Transgenic transchromosomal rodents for making human antibodies
|
|
US20030082630A1
(en)
|
2001-04-26 |
2003-05-01 |
Maxygen, Inc. |
Combinatorial libraries of monomer domains
|
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
|
IL161677A0
(en)
*
|
2001-11-08 |
2004-09-27 |
Protein Design Labs |
Stable liquid pharmaceutical formulation of igg antibodies
|
|
BR0309844A
(pt)
|
2002-05-07 |
2005-02-15 |
Control Delivery Sys Inc |
Processos para formação de um dispositivo para a distribuição de droga
|
|
EP1572103A4
(en)
|
2002-11-15 |
2008-02-13 |
Centocor Inc |
ANTI-ANGIOGENIC USES OF IL-6 ANTAGONISTS
|
|
AU2003293543A1
(en)
*
|
2002-12-13 |
2004-07-09 |
Abgenix, Inc. |
System and method for stabilizing antibodies with histidine
|
|
AP2006003670A0
(en)
|
2003-12-23 |
2006-06-30 |
Rinat Neuroscience Corp |
Agonist anti-TRKC antibodies and methods using same
|
|
AU2005274905B2
(en)
|
2004-08-04 |
2010-12-23 |
Mentrik Biotech, Llc |
Variant Fc regions
|
|
WO2006028936A2
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
ATE550353T1
(de)
|
2005-12-30 |
2012-04-15 |
Merck Patent Gmbh |
Die bindung von mit il-6ralpha komplexiertem il-6 an gp130 verhindernde anti-il-6-antikörper
|
|
US20110059101A9
(en)
|
2006-03-13 |
2011-03-10 |
Ablynx N.V. |
Amino Acid Sequences Directed Against Il-6 And Polypetides Comprising The Same For The Treatment Of Diseases And Disorders Associated With Il-6 Mediated Signalling
|
|
EP2021463B1
(en)
|
2006-05-19 |
2016-11-23 |
Alder Biopharmaceuticals, Inc. |
Culture method for obtaining a clonal population of antigen-specific b cells
|
|
CA2675602A1
(en)
|
2007-02-16 |
2008-08-21 |
Wyeth |
Protein formulations containing sorbitol
|
|
DK2164514T3
(en)
|
2007-05-21 |
2017-02-27 |
Alderbio Holdings Llc |
Antibodies to IL-6 and its use
|
|
PL2198007T3
(pl)
*
|
2007-09-14 |
2018-03-30 |
Sanofi Pasteur Biologics, Llc |
Kompozycje farmaceutyczne zawierające toksoidy A i B Clostridium difficile
|
|
AU2008330125B2
(en)
|
2007-11-21 |
2012-11-22 |
Amgen Inc. |
Wise binding antibodies and epitopes
|
|
US20100187601A1
(en)
|
2007-12-12 |
2010-07-29 |
Fujio Masuoka |
Semiconductor device
|
|
CA2711984A1
(en)
|
2008-01-15 |
2009-07-23 |
Abbott Gmbh & Co. Kg |
Powdered protein compositions and methods of making same
|
|
PY09026846A
(es)
|
2008-08-05 |
2015-09-01 |
Novartis Ag |
Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
|
|
CN102123796B
(zh)
|
2008-09-12 |
2013-09-11 |
Kdf株式会社 |
喷水装置
|
|
WO2010039750A2
(en)
*
|
2008-10-01 |
2010-04-08 |
Monsanto Technology Llc |
Transgenic plants with enhanced agronomic traits
|
|
US8992920B2
(en)
*
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
KR20110091777A
(ko)
|
2008-11-26 |
2011-08-12 |
글락소 그룹 리미티드 |
폴리펩티드, 항체 가변 도메인 및 길항제
|
|
CN104119438A
(zh)
|
2009-01-29 |
2014-10-29 |
米迪缪尼有限公司 |
延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用
|
|
JO3417B1
(ar)
*
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
RU2012157167A
(ru)
*
|
2010-07-12 |
2014-08-20 |
КовЭкс Текнолоджиз Айэлэнд Лимитед |
Полифункциональные антительные конъюгаты
|
|
CA2857194A1
(en)
*
|
2011-12-07 |
2013-06-13 |
Thomas M. Dillon |
Igg2 disulfide isoform separation
|
|
AU2013267310A1
(en)
|
2012-06-01 |
2014-12-11 |
Ophthotech Corporation |
Compositions comprising an anti-PDGF aptamer and a VEGF antagonist
|
|
SG11201408538PA
(en)
|
2012-07-13 |
2015-02-27 |
Roche Glycart Ag |
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
|
|
PE20150964A1
(es)
*
|
2012-09-07 |
2015-07-25 |
Coherus Biosciences Inc |
Formulaciones acuosas estables de adalimumab
|
|
CN104768578A
(zh)
*
|
2012-10-25 |
2015-07-08 |
米迪缪尼有限公司 |
稳定的低粘度抗体配制品
|
|
CN104903349B
(zh)
*
|
2012-11-08 |
2018-10-19 |
十一生物治疗股份有限公司 |
Il-6拮抗剂及其应用
|
|
DK4374873T3
(da)
*
|
2013-07-12 |
2025-11-03 |
Astellas Us Llc |
Middel til brug ved behandling eller forebyggelse af oftalmologiske tilstande
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
JP6594438B2
(ja)
*
|
2014-11-07 |
2019-10-23 |
セセン バイオ, インコーポレイテッド |
改善されたil−6抗体
|
|
WO2016073894A1
(en)
|
2014-11-07 |
2016-05-12 |
Eleven Biotherapeutics, Inc. |
Therapeutic agents with increased ocular retention
|