|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4548990A
(en)
|
1983-08-15 |
1985-10-22 |
Ciba-Geigy Corporation |
Crosslinked, porous polymers for controlled drug delivery
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5476996A
(en)
|
1988-06-14 |
1995-12-19 |
Lidak Pharmaceuticals |
Human immune system in non-human animal
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
JPH06508511A
(ja)
|
1990-07-10 |
1994-09-29 |
ケンブリッジ アンティボディー テクノロジー リミティド |
特異的な結合ペアーの構成員の製造方法
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
DE69233769D1
(de)
|
1991-03-01 |
2009-09-24 |
Dyax Corp |
Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
ATE181571T1
(de)
|
1991-09-23 |
1999-07-15 |
Medical Res Council |
Methoden zur herstellung humanisierter antikörper
|
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
|
EP0746609A4
(en)
|
1991-12-17 |
1997-12-17 |
Genpharm Int |
NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES
|
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
DK0672142T3
(da)
|
1992-12-04 |
2001-06-18 |
Medical Res Council |
Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
FR2734739B1
(fr)
|
1995-06-01 |
1997-07-11 |
Gec Alsthom Stein Ind |
Dispositif de surveillance d'un broyeur a boulets
|
|
EP0795743A3
(en)
|
1996-03-15 |
1998-02-25 |
Japan Tobacco Inc. |
Method and apparatus for infra-red moisture measurement
|
|
US5839430A
(en)
|
1996-04-26 |
1998-11-24 |
Cama; Joseph |
Combination inhaler and peak flow rate meter
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
DK0979281T3
(da)
|
1997-05-02 |
2005-11-21 |
Genentech Inc |
Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele
|
|
WO1998056915A2
(en)
|
1997-06-12 |
1998-12-17 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
|
US6358058B1
(en)
|
1998-01-30 |
2002-03-19 |
1263152 Ontario Inc. |
Aerosol dispensing inhaler training device
|
|
DK1137941T4
(da)
|
1998-12-10 |
2014-01-06 |
Brystol Myers Squibb Company |
Protein-scaffolds til antistof-mimetika og andre bindingsproteiner
|
|
NZ517202A
(en)
|
1999-08-24 |
2004-05-28 |
Medarex Inc |
Human CTLA-4 antibodies and their uses
|
|
JP3523245B1
(ja)
|
2000-11-30 |
2004-04-26 |
メダレックス,インコーポレーテッド |
ヒト抗体作製用トランスジェニック染色体導入齧歯動物
|
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
|
WO2002088171A2
(en)
|
2001-04-26 |
2002-11-07 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
IL161677A0
(en)
*
|
2001-11-08 |
2004-09-27 |
Protein Design Labs |
Stable liquid pharmaceutical formulation of igg antibodies
|
|
MXPA04011004A
(es)
|
2002-05-07 |
2005-01-25 |
Control Delivery Sys Inc |
Procesos para formar un dispositivo de administracion de farmaco.
|
|
EP1572103A4
(en)
|
2002-11-15 |
2008-02-13 |
Centocor Inc |
ANTI-ANGIOGENIC USES OF IL-6 ANTAGONISTS
|
|
AU2003293543A1
(en)
*
|
2002-12-13 |
2004-07-09 |
Abgenix, Inc. |
System and method for stabilizing antibodies with histidine
|
|
SG166768A1
(en)
|
2003-12-23 |
2010-12-29 |
Rinat Neuroscience Corp |
Agonist anti-trkc antibodies and methods using same
|
|
ES2426817T3
(es)
|
2004-08-04 |
2013-10-25 |
Mentrik Biotech, Llc |
Regiones Fc variantes
|
|
AU2005282700A1
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
CN101346395A
(zh)
|
2005-12-30 |
2009-01-14 |
默克专利有限公司 |
阻止复合有IL-6Rα的IL-6与GP130结合的抗IL-6抗体
|
|
WO2007104529A2
(en)
|
2006-03-13 |
2007-09-20 |
Ablynx N.V. |
Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
DK2021463T3
(en)
|
2006-05-19 |
2017-01-16 |
Alder Biopharmaceuticals Inc |
Culture method to obtain a cloned population of antigen-specific B cells
|
|
EP2124889A2
(en)
|
2007-02-16 |
2009-12-02 |
Wyeth a Corporation of the State of Delaware |
Protein formulations containing sorbitol
|
|
KR101741731B1
(ko)
|
2007-05-21 |
2017-05-30 |
앨더바이오 홀딩스 엘엘씨 |
Il-6에 대한 항체 및 이의 용도
|
|
AU2008299885C1
(en)
*
|
2007-09-14 |
2015-06-25 |
Sanofi Pasteur Biologics, Llc |
Pharmaceutical compositions containing clostridium difficile toxoids A and B
|
|
AU2008330125B2
(en)
|
2007-11-21 |
2012-11-22 |
Amgen Inc. |
Wise binding antibodies and epitopes
|
|
US20100187601A1
(en)
|
2007-12-12 |
2010-07-29 |
Fujio Masuoka |
Semiconductor device
|
|
BRPI0907186A2
(pt)
|
2008-01-15 |
2015-07-14 |
Abbott Gmbh & Co Kg |
Composições proteicas pulverizadas e métodos para sua produção
|
|
PY09026846A
(es)
|
2008-08-05 |
2015-09-01 |
Novartis Ag |
Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
|
|
PL2324930T3
(pl)
|
2008-09-12 |
2013-02-28 |
Kdf Co Ltd |
Urządzenie wytryskujące wodę
|
|
WO2010039750A2
(en)
*
|
2008-10-01 |
2010-04-08 |
Monsanto Technology Llc |
Transgenic plants with enhanced agronomic traits
|
|
US8992920B2
(en)
*
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
CN102224169A
(zh)
|
2008-11-26 |
2011-10-19 |
葛兰素集团有限公司 |
多肽、抗体可变结构域和拮抗剂
|
|
JP2012516158A
(ja)
|
2009-01-29 |
2012-07-19 |
メディミューン,エルエルシー |
延長したインビボ半減期を有するヒト抗il−6抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用
|
|
JO3417B1
(ar)
*
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
PE20130643A1
(es)
*
|
2010-07-12 |
2013-06-07 |
Covx Technologies Ireland Ltd |
Conjugados de anticuerpos multifuncionales
|
|
JP2015502959A
(ja)
*
|
2011-12-07 |
2015-01-29 |
アムジェン インコーポレイテッド |
IgG2ジスルフィドアイソフォームの分離
|
|
AR091237A1
(es)
|
2012-06-01 |
2015-01-21 |
Ophthotech Corp |
Composiciones que comprenden un aptamero anti factor de crecimiento derivado de plaquetas (anti-pdgf) y un antagonista de factor de crecimiento de endotelio vascular (vegf)
|
|
EP2872534B1
(en)
|
2012-07-13 |
2018-08-08 |
Roche Glycart AG |
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
|
|
AU2013312300A1
(en)
*
|
2012-09-07 |
2015-04-16 |
Coherus Biosciences, Inc. |
Stable aqueous formulations of adalimumab
|
|
CN106421782A
(zh)
|
2012-10-25 |
2017-02-22 |
米迪缪尼有限公司 |
稳定的低粘度抗体配制品
|
|
HK1211599A1
(en)
*
|
2012-11-08 |
2016-05-27 |
Eleven Biotherapeutics, Inc. |
Il-6 antagonists and uses thereof
|
|
EA201690212A8
(ru)
*
|
2013-07-12 |
2016-08-31 |
Офтотек Корпорейшн |
Способы лечения или профилактики офтальмологических патологических состояний
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
EP4268843B1
(en)
*
|
2014-11-07 |
2025-09-03 |
F. Hoffmann-La Roche Ltd |
Improved il-6 antibodies
|
|
WO2016073894A1
(en)
|
2014-11-07 |
2016-05-12 |
Eleven Biotherapeutics, Inc. |
Therapeutic agents with increased ocular retention
|