JP2011504872A5 - - Google Patents
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- JP2011504872A5 JP2011504872A5 JP2010511295A JP2010511295A JP2011504872A5 JP 2011504872 A5 JP2011504872 A5 JP 2011504872A5 JP 2010511295 A JP2010511295 A JP 2010511295A JP 2010511295 A JP2010511295 A JP 2010511295A JP 2011504872 A5 JP2011504872 A5 JP 2011504872A5
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- Prior art keywords
- antibody
- composition
- complement
- fragment
- item
- Prior art date
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- 239000000203 mixture Substances 0.000 claims description 24
- 230000000295 complement effect Effects 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 18
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 18
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 16
- 208000035475 disorder Diseases 0.000 claims description 14
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 12
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 12
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 12
- 208000002780 macular degeneration Diseases 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 9
- 230000002612 cardiopulmonary effect Effects 0.000 claims description 8
- 201000005667 central retinal vein occlusion Diseases 0.000 claims description 8
- 208000028867 ischemia Diseases 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 8
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 8
- 238000001356 surgical procedure Methods 0.000 claims description 8
- 230000024203 complement activation Effects 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 4
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 4
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims description 4
- 206010055665 Corneal neovascularisation Diseases 0.000 claims description 4
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 4
- 206010048554 Endothelial dysfunction Diseases 0.000 claims description 4
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 4
- 206010019280 Heart failures Diseases 0.000 claims description 4
- 201000002563 Histoplasmosis Diseases 0.000 claims description 4
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 4
- 206010021263 IgA nephropathy Diseases 0.000 claims description 4
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 4
- 208000004451 Membranoproliferative Glomerulonephritis Diseases 0.000 claims description 4
- 241000721454 Pemphigus Species 0.000 claims description 4
- 206010035669 Pneumonia aspiration Diseases 0.000 claims description 4
- 208000033626 Renal failure acute Diseases 0.000 claims description 4
- 208000017442 Retinal disease Diseases 0.000 claims description 4
- 206010038923 Retinopathy Diseases 0.000 claims description 4
- 206010046851 Uveitis Diseases 0.000 claims description 4
- 206010047115 Vasculitis Diseases 0.000 claims description 4
- 201000011040 acute kidney failure Diseases 0.000 claims description 4
- 208000012998 acute renal failure Diseases 0.000 claims description 4
- 230000033115 angiogenesis Effects 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 201000009807 aspiration pneumonia Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
- 201000000159 corneal neovascularization Diseases 0.000 claims description 4
- 210000004351 coronary vessel Anatomy 0.000 claims description 4
- 201000003278 cryoglobulinemia Diseases 0.000 claims description 4
- 208000001309 degenerative myopia Diseases 0.000 claims description 4
- 230000004340 degenerative myopia Effects 0.000 claims description 4
- 201000001981 dermatomyositis Diseases 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims description 4
- 201000011190 diabetic macular edema Diseases 0.000 claims description 4
- 230000009429 distress Effects 0.000 claims description 4
- 206010014801 endophthalmitis Diseases 0.000 claims description 4
- 230000008694 endothelial dysfunction Effects 0.000 claims description 4
- 238000001631 haemodialysis Methods 0.000 claims description 4
- 230000000322 hemodialysis Effects 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 4
- 230000000414 obstructive effect Effects 0.000 claims description 4
- 230000002685 pulmonary effect Effects 0.000 claims description 4
- 230000010410 reperfusion Effects 0.000 claims description 4
- 208000011580 syndromic disease Diseases 0.000 claims description 4
- 230000000451 tissue damage Effects 0.000 claims description 4
- 231100000827 tissue damage Toxicity 0.000 claims description 4
- 208000006542 von Hippel-Lindau disease Diseases 0.000 claims description 4
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 229940124639 Selective inhibitor Drugs 0.000 claims description 2
- 239000007857 degradation product Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000027993 eye symptom Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 21
- 239000005557 antagonist Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93372107P | 2007-06-07 | 2007-06-07 | |
| US60/933,721 | 2007-06-07 | ||
| US5506808P | 2008-05-21 | 2008-05-21 | |
| US60/055,068 | 2008-05-21 | ||
| PCT/US2008/065771 WO2008154251A2 (en) | 2007-06-07 | 2008-06-04 | C3b antibodies and methods for the prevention and treatment of complement- associated disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014020001A Division JP5980249B2 (ja) | 2007-06-07 | 2014-02-05 | 補体が関係している障害の予防および処置のためのｃ３ｂ抗体ならびに方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011504872A JP2011504872A (ja) | 2011-02-17 |
| JP2011504872A5 true JP2011504872A5 (enExample) | 2011-06-02 |
| JP5683265B2 JP5683265B2 (ja) | 2015-03-11 |
Family
ID=39712089
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511295A Expired - Fee Related JP5683265B2 (ja) | 2007-06-07 | 2008-06-04 | 補体が関係している障害の予防および処置のためのｃ３ｂ抗体ならびに方法 |
| JP2014020001A Expired - Fee Related JP5980249B2 (ja) | 2007-06-07 | 2014-02-05 | 補体が関係している障害の予防および処置のためのｃ３ｂ抗体ならびに方法 |
| JP2016145975A Pending JP2016204382A (ja) | 2007-06-07 | 2016-07-26 | 補体が関係している障害の予防および処置のためのｃ３ｂ抗体ならびに方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014020001A Expired - Fee Related JP5980249B2 (ja) | 2007-06-07 | 2014-02-05 | 補体が関係している障害の予防および処置のためのｃ３ｂ抗体ならびに方法 |
| JP2016145975A Pending JP2016204382A (ja) | 2007-06-07 | 2016-07-26 | 補体が関係している障害の予防および処置のためのｃ３ｂ抗体ならびに方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8012473B2 (enExample) |
| EP (1) | EP2162470A2 (enExample) |
| JP (3) | JP5683265B2 (enExample) |
| KR (3) | KR20170023212A (enExample) |
| CN (1) | CN101809034B (enExample) |
| AR (1) | AR066916A1 (enExample) |
| AU (1) | AU2008262048B2 (enExample) |
| BR (1) | BRPI0812767A2 (enExample) |
| CA (1) | CA2690124A1 (enExample) |
| CL (1) | CL2008001656A1 (enExample) |
| IL (1) | IL201820A0 (enExample) |
| MX (1) | MX2009013082A (enExample) |
| PE (1) | PE20090416A1 (enExample) |
| RU (1) | RU2473563C2 (enExample) |
| SG (2) | SG10201608952QA (enExample) |
| TW (2) | TWI441832B (enExample) |
| WO (1) | WO2008154251A2 (enExample) |
| ZA (1) | ZA200907575B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007261315B2 (en) | 2006-06-21 | 2012-10-25 | Musc Foundation For Research Development | Targeting complement factor H for treatment of diseases |
| PE20091388A1 (es) * | 2007-11-02 | 2009-09-24 | Novartis Ag | Moleculas y metodos para modular el componente de complemento |
| US20100291106A1 (en) * | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| AU2010266127B2 (en) | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| EA201290286A1 (ru) | 2009-11-05 | 2013-01-30 | Алексион Кембридж Корпорейшн | Лечение пароксизмальной ночной гемоглобинурии, гемолитических анемий и патологических состояний с вовлечением внутрисосудистого и внесосудистого гемолиза |
| WO2011084496A1 (en) * | 2009-12-16 | 2011-07-14 | Abbott Biotherapeutics Corp. | Anti-her2 antibodies and their uses |
| JP2013524213A (ja) * | 2010-03-31 | 2013-06-17 | アナマー エービー | 炎症をもたらす組織分解を検出する方法 |
| SG185483A1 (en) | 2010-05-14 | 2012-12-28 | Univ Colorado Regents | Improved complement receptor 2 (cr2) targeting groups |
| EP2585110A4 (en) | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| WO2012075023A2 (en) * | 2010-11-29 | 2012-06-07 | Novelmed Therapeutics, Inc. | Neoantibodies for diagnosing tissue injury |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| CN104220453B (zh) * | 2012-04-03 | 2018-03-09 | 诺沃姆德治疗公司 | 人源化的嵌合抗因子c3抗体及其用途 |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| HK1218300A1 (zh) * | 2013-01-23 | 2017-02-10 | Musc Foundation For Research Development | 基於天然抗體的靶向結構體及其應用 |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| US10183989B2 (en) * | 2013-12-24 | 2019-01-22 | Novelmed Therapeutics, Inc. | Methods of treating ocular diseases |
| HUE050921T2 (hu) * | 2014-02-26 | 2021-01-28 | Allergan Inc | C5 komplementkomponens antitestek |
| SG10202104175YA (en) | 2014-02-27 | 2021-06-29 | Allergan Inc | COMPLEMENT FACTOR Bb ANTIBODIES |
| KR101981532B1 (ko) | 2014-06-12 | 2019-09-02 | 라 파마슈티컬스 인코포레이티드 | 보체 활성의 조절 |
| KR102709811B1 (ko) * | 2014-08-20 | 2024-09-24 | 스티흐팅 산퀸 불드포르지닝 | 인자 h 강화 항체 및 그의 용도 |
| PL3250230T3 (pl) | 2015-01-28 | 2022-02-14 | Ra Pharmaceuticals, Inc. | Modulatory aktywności dopełniacza |
| RU2584582C1 (ru) * | 2015-03-16 | 2016-05-20 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Моноклональное антитело сс3-4 к конформационному эпитопу с3 человека, штамм гибридной днк мыши рккк(п)764д - продуцент моноклонального антитела сс3-4 |
| RU2733720C2 (ru) | 2015-12-16 | 2020-10-06 | Ра Фармасьютикалз, Инк. | Модуляторы активности комплемента |
| GB201608046D0 (en) * | 2016-05-09 | 2016-06-22 | Cambridge Entpr Ltd And Syndey Children S Hospitals Network Randwick And Westmead Incorporating The | Treatment of complement-mediated disorders |
| RU2630647C1 (ru) * | 2016-05-27 | 2017-09-11 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К КОНФОРМАЦИОННОМУ ЭПИТОПУ С3 КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА, ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), И ШТАММ КЛЕТОК ЯИЧНИКОВ КИТАЙСКОГО ХОМЯЧКА CHO-humC34-ПРОДУЦЕНТ ДАННОГО ГУМАНИЗИРОВАННОГО АНТИТЕЛА |
| US11007254B2 (en) | 2016-10-17 | 2021-05-18 | Musc Foundation For Research Development | Compositions and methods for treating central nervous system injury |
| MX2019006527A (es) | 2016-12-07 | 2019-08-01 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
| MX2019010219A (es) * | 2017-02-27 | 2020-02-07 | Regeneron Pharma | Modelo humanizado de trastornos renales y hepáticos. |
| TW201938184A (zh) | 2017-12-04 | 2019-10-01 | 美商Ｒａ製藥公司 | 補體活性之調節劑 |
| GB201800620D0 (en) * | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| BR112020019907A2 (pt) | 2018-04-03 | 2021-01-05 | Ngm Biopharmaceuticals, Inc. | Agentes de ligação a c3 e métodos de uso dos mesmos |
| RU2687609C1 (ru) * | 2018-05-30 | 2019-05-15 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Гуманизированное антитело к конформационному эпитопу сз компонента комплемента человека |
| EP4257602A3 (en) | 2018-06-11 | 2023-12-27 | Aarhus Universitet | Single domain antibodies for complement regulation |
| GB2583560A (en) | 2018-12-11 | 2020-11-04 | Admirx Inc | Fusion protein constructs for complement associated disease |
| CN113543796A (zh) | 2019-03-08 | 2021-10-22 | Ra制药公司 | 齐鲁考普作为深层组织穿透性c5抑制剂 |
| US20230115176A1 (en) | 2019-03-29 | 2023-04-13 | Ra Pharmaceuticals, Inc. | Complement Modulators and Related Methods |
| US20220211799A1 (en) | 2019-04-24 | 2022-07-07 | Ra Pharmaceuticals, Inc. | Compositions and methods for modulating complement activity |
| KR20220057530A (ko) | 2019-07-17 | 2022-05-09 | 제미니 테라퓨틱스 서브, 인코포레이티드 | 인자 h 강화 항체 및 이의 용도 |
| AU2022420788A1 (en) | 2021-12-22 | 2024-05-16 | Boehringer Ingelheim International Gmbh | Anti-c3 antibodies and antigen-binding fragments thereof and their uses for treating eye or ocular diseases |
| KR20230105972A (ko) * | 2022-01-05 | 2023-07-12 | 주식회사 카나프테라퓨틱스 | 혈관신생 억제제가 결합된 항-C3b 항체 또는 항-C5 항체 및 이의 용도 |
| WO2023212298A1 (en) * | 2022-04-29 | 2023-11-02 | Broadwing Bio Llc | Bispecific antibodies and methods of treating ocular disease |
| JP2025529954A (ja) | 2022-08-30 | 2025-09-09 | ロングバイオ ファーマ （スーチョウ） カンパニー、リミテッド | 抗ヒト補体ｃ５抗体およびその融合タンパク質 |
| IL319384A (en) * | 2022-09-20 | 2025-05-01 | Visterra Inc | Treatment of complement-mediated diseases and disorders with C3B antibodies |
| CN118005802A (zh) | 2022-11-10 | 2024-05-10 | 天辰生物医药(苏州)有限公司 | 补体抑制杂合蛋白突变体及其抗体融合蛋白 |
| WO2024227154A1 (en) * | 2023-04-28 | 2024-10-31 | Broadwing Bio Llc | Complement component 3 (c3)-specific antibodies and uses thereof |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| EP0435911B1 (en) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| ES2091684T3 (es) | 1992-11-13 | 1996-11-01 | Idec Pharma Corp | Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b. |
| AU6808194A (en) * | 1993-05-31 | 1994-12-20 | Chugai Seiyaku Kabushiki Kaisha | Reconstructed human antibody against human interleukin-6 |
| HUP9900789A3 (en) * | 1996-03-07 | 2001-10-29 | Imutran Ltd | Down-regulation resistant c3 convertase |
| US8088386B2 (en) | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
| US8007798B2 (en) * | 1997-11-21 | 2011-08-30 | Genentech, Inc. | Treatment of complement-associated disorders |
| DE69939813D1 (de) * | 1998-02-20 | 2008-12-11 | Tanox Inc | Inhibitoren der komplement-aktivierung |
| CA2488441C (en) | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| US7959919B2 (en) * | 2003-11-19 | 2011-06-14 | Novelmed Therapeutics, Inc. | Method of inhibiting factor B-mediated complement activation |
| US20090004183A1 (en) * | 2004-07-23 | 2009-01-01 | Taylor Ronald P | Compositions and Methods for Regulating the Alternative Pathway of Complement |
| US8420783B2 (en) * | 2004-12-08 | 2013-04-16 | Immunomedics, Inc. | Method and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases |
| US8192742B2 (en) * | 2007-03-23 | 2012-06-05 | NovelMed Therapeutics | Method of inhibiting complement activation with human anti-factor C3 antibodies and use thereof |
-
2008
- 2008-06-04 AU AU2008262048A patent/AU2008262048B2/en not_active Ceased
- 2008-06-04 KR KR1020177004887A patent/KR20170023212A/ko not_active Ceased
- 2008-06-04 CN CN200880102282.9A patent/CN101809034B/zh not_active Expired - Fee Related
- 2008-06-04 BR BRPI0812767-0A2A patent/BRPI0812767A2/pt not_active IP Right Cessation
- 2008-06-04 SG SG10201608952QA patent/SG10201608952QA/en unknown
- 2008-06-04 WO PCT/US2008/065771 patent/WO2008154251A2/en not_active Ceased
- 2008-06-04 KR KR1020157002416A patent/KR20150029002A/ko not_active Abandoned
- 2008-06-04 MX MX2009013082A patent/MX2009013082A/es active IP Right Grant
- 2008-06-04 CA CA2690124A patent/CA2690124A1/en not_active Abandoned
- 2008-06-04 EP EP08756688A patent/EP2162470A2/en not_active Withdrawn
- 2008-06-04 JP JP2010511295A patent/JP5683265B2/ja not_active Expired - Fee Related
- 2008-06-04 KR KR1020107000198A patent/KR101572700B1/ko not_active Expired - Fee Related
- 2008-06-04 RU RU2009149385/10A patent/RU2473563C2/ru not_active IP Right Cessation
- 2008-06-04 SG SG2012041125A patent/SG182165A1/en unknown
- 2008-06-06 CL CL2008001656A patent/CL2008001656A1/es unknown
- 2008-06-06 PE PE2008000973A patent/PE20090416A1/es not_active Application Discontinuation
- 2008-06-06 TW TW097121292A patent/TWI441832B/zh not_active IP Right Cessation
- 2008-06-06 AR ARP080102436A patent/AR066916A1/es unknown
- 2008-06-06 US US12/157,073 patent/US8012473B2/en not_active Expired - Fee Related
- 2008-06-06 TW TW103111348A patent/TWI557137B/zh not_active IP Right Cessation
-
2009
- 2009-10-28 ZA ZA2009/07575A patent/ZA200907575B/en unknown
- 2009-10-29 IL IL201820A patent/IL201820A0/en not_active IP Right Cessation
-
2011
- 2011-07-18 US US13/135,907 patent/US8377437B2/en not_active Expired - Fee Related
-
2014
- 2014-02-05 JP JP2014020001A patent/JP5980249B2/ja not_active Expired - Fee Related
-
2016
- 2016-07-26 JP JP2016145975A patent/JP2016204382A/ja active Pending
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