JP2016529255A5 - - Google Patents

Download PDF

Info

Publication number
JP2016529255A5
JP2016529255A5 JP2016534815A JP2016534815A JP2016529255A5 JP 2016529255 A5 JP2016529255 A5 JP 2016529255A5 JP 2016534815 A JP2016534815 A JP 2016534815A JP 2016534815 A JP2016534815 A JP 2016534815A JP 2016529255 A5 JP2016529255 A5 JP 2016529255A5
Authority
JP
Japan
Prior art keywords
seq
region
heavy chain
light chain
variable region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016534815A
Other languages
English (en)
Japanese (ja)
Other versions
JP6696899B2 (ja
JP2016529255A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/050896 external-priority patent/WO2015023752A1/en
Publication of JP2016529255A publication Critical patent/JP2016529255A/ja
Publication of JP2016529255A5 publication Critical patent/JP2016529255A5/ja
Priority to JP2020076578A priority Critical patent/JP6907380B2/ja
Application granted granted Critical
Publication of JP6696899B2 publication Critical patent/JP6696899B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016534815A 2013-08-13 2014-08-13 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用 Active JP6696899B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020076578A JP6907380B2 (ja) 2013-08-13 2020-04-23 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361865451P 2013-08-13 2013-08-13
US61/865,451 2013-08-13
EP14305757 2014-05-22
EP14305757.8 2014-05-22
PCT/US2014/050896 WO2015023752A1 (en) 2013-08-13 2014-08-13 Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020076578A Division JP6907380B2 (ja) 2013-08-13 2020-04-23 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用

Publications (3)

Publication Number Publication Date
JP2016529255A JP2016529255A (ja) 2016-09-23
JP2016529255A5 true JP2016529255A5 (enExample) 2018-06-28
JP6696899B2 JP6696899B2 (ja) 2020-05-20

Family

ID=56194112

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2016534815A Active JP6696899B2 (ja) 2013-08-13 2014-08-13 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用
JP2020076578A Active JP6907380B2 (ja) 2013-08-13 2020-04-23 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用
JP2021107196A Active JP7223069B2 (ja) 2013-08-13 2021-06-29 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2023014335A Active JP7568756B2 (ja) 2013-08-13 2023-02-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2024172861A Active JP7764565B2 (ja) 2013-08-13 2024-10-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2025177454A Pending JP2026031550A (ja) 2013-08-13 2025-10-22 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2020076578A Active JP6907380B2 (ja) 2013-08-13 2020-04-23 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用
JP2021107196A Active JP7223069B2 (ja) 2013-08-13 2021-06-29 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2023014335A Active JP7568756B2 (ja) 2013-08-13 2023-02-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2024172861A Active JP7764565B2 (ja) 2013-08-13 2024-10-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2025177454A Pending JP2026031550A (ja) 2013-08-13 2025-10-22 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用

Country Status (19)

Country Link
US (4) US9845363B2 (enExample)
EP (1) EP4707306A3 (enExample)
JP (6) JP6696899B2 (enExample)
KR (1) KR20160035077A (enExample)
CN (2) CN105705520B (enExample)
BR (1) BR112016002753A2 (enExample)
CL (1) CL2016000324A1 (enExample)
CR (2) CR20190319A (enExample)
DK (1) DK3620472T3 (enExample)
DO (1) DOP2016000042A (enExample)
EA (1) EA033403B1 (enExample)
ES (2) ES2770507T3 (enExample)
HK (1) HK1221725A1 (enExample)
MX (2) MX2016001851A (enExample)
PE (1) PE20160244A1 (enExample)
PH (1) PH12016500239A1 (enExample)
SG (1) SG10201710013RA (enExample)
TN (1) TN2016000048A1 (enExample)
UA (1) UA118267C2 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016002753A2 (pt) * 2013-08-13 2017-11-21 Sanofi Sa anticorpos contra o inibidor-1 de ativador de plasminogênio (pai-1) e usos dos mesmos
EP3395354B1 (en) 2015-12-18 2024-05-22 Talengen International Limited Plasminogen for use in treating diabetic nephropathy
WO2017101871A1 (zh) 2015-12-18 2017-06-22 深圳瑞健生命科学研究院有限公司 一种预防和治疗心血管病的新方法
JP2019500426A (ja) 2015-12-18 2019-01-10 タレンゲン インターナショナル リミティッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 糖尿病網膜症を予防または治療するための方法
TWI653981B (zh) 2015-12-18 2019-03-21 深圳瑞健生命科學硏究院有限公司 Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury
CN108210897A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗肺纤维化的药物及其用途
CN108210904A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 治疗动脉粥样硬化及其并发症的药物及其用途
JP7168990B2 (ja) 2016-12-15 2022-11-10 タレンゲン インターナショナル リミテッド 肥満症を予防および治療するための方法および薬物
CA3047170A1 (en) * 2016-12-15 2018-06-21 Talengen International Limited Method for preventing and treating drug-induced renal injury
JP7213552B2 (ja) * 2016-12-15 2023-01-27 タレンゲン インターナショナル リミテッド 肝の繊維化を予防及び治療するための方法
TWI750189B (zh) 2016-12-15 2021-12-21 大陸商深圳瑞健生命科學研究院有限公司 一種治療冠狀動脈粥樣硬化及其併發症的方法
WO2018107701A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种新的降血糖和提高糖耐量的药物
CA3067890A1 (en) 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
MY205541A (en) * 2017-08-03 2024-10-25 Alector Llc Anti-cd33 antibodies and methods of use thereof
JP7604376B2 (ja) 2018-12-28 2024-12-23 バーテックス ファーマシューティカルズ インコーポレイテッド 改変ウロキナーゼ型プラスミノゲンアクティベータポリペプチドおよび使用方法
US20220340665A1 (en) 2019-09-30 2022-10-27 Renascience Inc. Inhibitor against expression of immune checkpoint molecule
US20220380484A1 (en) * 2019-10-28 2022-12-01 Monash University Antibodies for binding plasminogen
TWI884192B (zh) * 2019-12-05 2025-05-21 美商西健公司 抗αＶβ６抗體及抗體-藥物結合物
EP4094776A4 (en) * 2020-02-11 2023-05-17 Talengen International Limited METHODS AND MEDICATIONS FOR THE TREATMENT OF VIRAL PENMONIA
CN111072780B (zh) * 2020-03-24 2020-06-23 深圳汉盛汇融再生医学科技有限公司 白血病干细胞抑制剂及其在治疗慢性粒细胞白血病中的应用
CN115515975A (zh) * 2020-05-21 2022-12-23 兹杜斯生命科学有限公司 Fc变体及其制备
CN114605550B (zh) * 2020-12-08 2023-09-22 东莞市朋志生物科技有限公司 抗ca19-9的抗体、其应用和检测ca19-9的试剂盒
CN114686442B (zh) * 2020-12-31 2023-11-07 广州万孚生物技术股份有限公司 一种杂交瘤细胞株及其应用
CN114686441B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 一种能分泌tPAI-C单克隆抗体的杂交瘤细胞株及其应用
WO2022204267A1 (en) * 2021-03-24 2022-09-29 Alkermes, Inc. Upar antibodies and fusion proteins with the same
CN115873120B (zh) * 2022-09-08 2025-10-21 厦门英博迈生物科技有限公司 一种纤溶酶α2纤溶酶抑制物复合物抗体及应用
CN116355091A (zh) * 2023-03-27 2023-06-30 陕西师范大学 一种抗人神经丝轻链的单克隆抗体21d2-30d3及其产品和应用
WO2025032553A1 (en) * 2023-08-10 2025-02-13 Cochlear Limited Methods of treating inner ear fibrosis
CN121554575B (zh) * 2026-01-22 2026-04-07 华中农业大学 猪δ冠状病毒N蛋白单克隆抗体及含有该抗体的乳胶免疫层析试纸条

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US6271352B1 (en) * 1985-07-12 2001-08-07 Fonden Til Fremme Af Eksperimentel Cancerforskning PAI-1 determination and use thereof
DK319685A (da) * 1985-07-12 1987-01-13 Fonden Til Fremme Af Eksperime Monoklonale antistoffer, fremgangsmaade til frembringelse af antistofferne, hybridomaceller, der producerer antistofferne, og anvendelse af antistofferne
US5422245A (en) * 1985-07-12 1995-06-06 Fonden Til Fremme Af Eksperimental Cancerforskning Plasminogen activator inhibitor monoclonal antibodies, hybridomas, monoclonal antibody production and use of the antibodies for assay of the inhibitors
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
NO891395L (no) 1988-04-04 1989-10-05 Teijin Ltd Reagenssystem.
JP2750732B2 (ja) * 1988-04-04 1998-05-13 帝人株式会社 ヒトプラスミノーゲンアクティベーターインヒビター・１−ヒト組織プラスミノーゲンアクティベーター複合体の免疫学的測定方法
WO1989012624A2 (en) 1988-06-14 1989-12-28 Cetus Corporation Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IE63847B1 (en) 1989-05-05 1995-06-14 Res Dev Foundation A novel antibody delivery system for biological response modifiers
US5460785A (en) 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
DE69127749T2 (de) 1990-03-20 1998-04-16 The Trustees Of Columbia University In The City Of New York, New York, N.Y. Chimäre antikörper mit rezeptor-bindenden liganden anstelle ihrer konstanten region
ATE218889T1 (de) 1990-11-09 2002-06-15 Stephen D Gillies Cytokine immunokonjugate
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
DK85193D0 (da) * 1993-07-16 1993-07-16 Cancerforskningsfondet Af 1989 Suppression of inhibitors
GB9422383D0 (en) 1994-11-05 1995-01-04 Wellcome Found Antibodies
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
GB9524973D0 (en) 1995-12-06 1996-02-07 Lynxvale Ltd Viral vectors
JPH1014592A (ja) * 1996-07-04 1998-01-20 Tanabe Seiyaku Co Ltd ラットｐａｉ−１に対するモノクローナル抗体
AU3968897A (en) 1996-08-02 1998-02-25 Bristol-Myers Squibb Company A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
WO1998023289A1 (en) 1996-11-27 1998-06-04 The General Hospital Corporation MODULATION OF IgG BINDING TO FcRn
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
EP0983303B1 (en) 1997-05-21 2006-03-08 Biovation Limited Method for the production of non-immunogenic proteins
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
CA2323757C (en) 1998-04-02 2011-08-02 Genentech, Inc. Antibody variants and fragments thereof
US6242195B1 (en) 1998-04-02 2001-06-05 Genentech, Inc. Methods for determining binding of an analyte to a receptor
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
JP2002522063A (ja) 1998-08-17 2002-07-23 アブジェニックス インコーポレイテッド 増加した血清半減期を有する改変された分子の生成
EP1006183A1 (en) 1998-12-03 2000-06-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Recombinant soluble Fc receptors
AU776910B2 (en) 1998-12-08 2004-09-23 Merck Patent Gesellschaft Mit Beschrankter Haftung Modifying protein immunogenicity
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
WO2001051085A1 (en) * 2000-01-14 2001-07-19 Tanox, Inc. Use of antagonists of plasminogen activator inhibitor-1 (pai-1) for the treatment of asthma and chronic obstructive pulmonary disease
WO2002034776A2 (en) 2000-10-26 2002-05-02 K.U.Leuven Research And Development Epitopes of pai-1
GB0029407D0 (en) 2000-12-01 2001-01-17 Affitech As Product
EP1355919B1 (en) 2000-12-12 2010-11-24 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
CA2476761A1 (en) * 2002-02-19 2003-08-28 Vanderbilt University Therapeutic methods employing pai-1 inhibitors and transgenic non-human animal for screening candidate pai-1 inhibitors
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US20040018557A1 (en) 2002-03-01 2004-01-29 Immunomedics, Inc. Bispecific antibody point mutations for enhancing rate of clearance
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
JP2006507297A (ja) * 2002-05-13 2006-03-02 チルドレンズ・ホスピタル・ロサンジェルス ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防
US7538195B2 (en) * 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
PT1534335E (pt) 2002-08-14 2012-02-28 Macrogenics Inc Anticorpos específicos de fcγriib e processos para a sua utilização
CA2832136C (en) 2002-09-27 2015-11-17 Xencor Optimized fc variants and methods for their generation
ATE480562T1 (de) 2002-10-15 2010-09-15 Facet Biotech Corp Veränderung von fcrn-bindungsaffinitäten oder von serumhalbwertszeiten von antikörpern mittels mutagenese
US7355008B2 (en) 2003-01-09 2008-04-08 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
AU2004266159A1 (en) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
GB0324368D0 (en) 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
EP1697520A2 (en) 2003-12-22 2006-09-06 Xencor, Inc. Fc polypeptides with novel fc ligand binding sites
JP4762156B2 (ja) 2004-01-12 2011-08-31 アプライド モレキュラー エボリューション，インコーポレイテッド Ｆｃ領域変異体
US7276585B2 (en) 2004-03-24 2007-10-02 Xencor, Inc. Immunoglobulin variants outside the Fc region
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
WO2006085967A2 (en) 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
EP3342782B1 (en) 2004-07-15 2022-08-17 Xencor, Inc. Optimized fc variants
WO2006047350A2 (en) 2004-10-21 2006-05-04 Xencor, Inc. IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
US8460362B2 (en) 2006-07-20 2013-06-11 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
US20090202524A1 (en) 2007-10-31 2009-08-13 Alcon Research, Ltd. Pai-1 expression and activity inhibitors for the treatment of ocular disorders
EP2195023B1 (en) 2007-08-29 2018-03-07 Sanofi Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
US7981415B2 (en) * 2007-09-07 2011-07-19 Cisthera, Inc. Humanized PAI-1 antibodies
US7771720B2 (en) 2007-09-07 2010-08-10 Cisthera, Inc. Humanized PAI-1 antibodies
WO2009154026A1 (ja) * 2008-06-20 2009-12-23 国立大学法人岡山大学 石灰化小球に対する抗体及びその用途
US20100254979A1 (en) * 2009-03-06 2010-10-07 Cisthera, Incorporated Humanized PAI-1 Antibodies and Uses Thereof
US20120114652A1 (en) 2010-05-03 2012-05-10 Abbott Laboratories Anti-pai-1 antibodies and methods of use thereof
BR112016002753A2 (pt) * 2013-08-13 2017-11-21 Sanofi Sa anticorpos contra o inibidor-1 de ativador de plasminogênio (pai-1) e usos dos mesmos

Similar Documents

Publication Publication Date Title
JP2025011161A5 (enExample)
JP2017507652A5 (enExample)
JP2017160208A5 (enExample)
JP2014514346A5 (enExample)
JP2017503820A5 (enExample)
JP2011504872A5 (enExample)
JP2020518599A5 (enExample)
WO2008154251A4 (en) C3b antibodies and methods for the prevention and treatment of complement- associated disorders
JP2015514110A5 (enExample)
JP2017506626A5 (enExample)
JP2017536414A5 (enExample)
JP2012021001A5 (enExample)
JP2016501892A5 (enExample)
JP2019513751A5 (enExample)
JP2015526440A5 (enExample)
RU2018129874A (ru) Антитела против фактора свертывания xi
JP2018505882A5 (enExample)
JP2014534239A5 (enExample)
RU2011142183A (ru) Средство для лечения ревматоидного артрита
JP2015503909A5 (enExample)
JP2016507470A5 (enExample)
JP2014158469A5 (enExample)
JP2019513726A5 (enExample)
JP2017537105A5 (enExample)
JP2018529661A5 (enExample)