JP2019523295A5 - - Google Patents
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- JP2019523295A5 JP2019523295A5 JP2019517209A JP2019517209A JP2019523295A5 JP 2019523295 A5 JP2019523295 A5 JP 2019523295A5 JP 2019517209 A JP2019517209 A JP 2019517209A JP 2019517209 A JP2019517209 A JP 2019517209A JP 2019523295 A5 JP2019523295 A5 JP 2019523295A5
- Authority
- JP
- Japan
- Prior art keywords
- myostatin
- pharmaceutical composition
- smn
- sma
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662349596P | 2016-06-13 | 2016-06-13 | |
| US62/349,596 | 2016-06-13 | ||
| US201762470157P | 2017-03-10 | 2017-03-10 | |
| US62/470,157 | 2017-03-10 | ||
| US201762486934P | 2017-04-18 | 2017-04-18 | |
| US62/486,934 | 2017-04-18 | ||
| US201762511702P | 2017-05-26 | 2017-05-26 | |
| US62/511,702 | 2017-05-26 | ||
| US201762512254P | 2017-05-30 | 2017-05-30 | |
| US62/512,254 | 2017-05-30 | ||
| PCT/US2017/037332 WO2017218592A1 (en) | 2016-06-13 | 2017-06-13 | Use of myostatin inhibitors and combination therapies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000367A Division JP7161554B2 (ja) | 2016-06-13 | 2021-01-05 | ミオスタチン阻害剤の使用および併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523295A JP2019523295A (ja) | 2019-08-22 |
| JP2019523295A5 true JP2019523295A5 (enExample) | 2020-07-16 |
| JP6823167B2 JP6823167B2 (ja) | 2021-01-27 |
Family
ID=59093642
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517209A Active JP6823167B2 (ja) | 2016-06-13 | 2017-06-13 | ミオスタチン阻害剤の使用および併用療法 |
| JP2021000367A Active JP7161554B2 (ja) | 2016-06-13 | 2021-01-05 | ミオスタチン阻害剤の使用および併用療法 |
| JP2022064360A Active JP7344337B2 (ja) | 2016-06-13 | 2022-04-08 | ミオスタチン阻害剤の使用および併用療法 |
| JP2023142275A Pending JP2023164920A (ja) | 2016-06-13 | 2023-09-01 | ミオスタチン阻害剤の使用および併用療法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000367A Active JP7161554B2 (ja) | 2016-06-13 | 2021-01-05 | ミオスタチン阻害剤の使用および併用療法 |
| JP2022064360A Active JP7344337B2 (ja) | 2016-06-13 | 2022-04-08 | ミオスタチン阻害剤の使用および併用療法 |
| JP2023142275A Pending JP2023164920A (ja) | 2016-06-13 | 2023-09-01 | ミオスタチン阻害剤の使用および併用療法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10946036B2 (enExample) |
| EP (3) | EP3785728A3 (enExample) |
| JP (4) | JP6823167B2 (enExample) |
| KR (4) | KR102271635B1 (enExample) |
| AU (4) | AU2017283546C1 (enExample) |
| CL (1) | CL2018003588A1 (enExample) |
| CY (1) | CY1123678T1 (enExample) |
| DK (1) | DK3368069T3 (enExample) |
| ES (1) | ES2830440T3 (enExample) |
| HR (1) | HRP20201764T1 (enExample) |
| HU (1) | HUE051480T2 (enExample) |
| IL (2) | IL301468A (enExample) |
| LT (1) | LT3368069T (enExample) |
| MY (2) | MY185614A (enExample) |
| PE (1) | PE20190205A1 (enExample) |
| PT (1) | PT3368069T (enExample) |
| RS (1) | RS61090B1 (enExample) |
| SI (1) | SI3368069T1 (enExample) |
| SM (1) | SMT202000598T1 (enExample) |
| WO (1) | WO2017218592A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| MX369784B (es) | 2007-09-26 | 2019-11-21 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| TWI654204B (zh) | 2010-11-30 | 2019-03-21 | 中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| CA2908350C (en) | 2013-04-02 | 2023-08-08 | Futa Mimoto | Fc region variant |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| AR103161A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina y regiones fc variantes así como métodos de uso |
| EP3816179A3 (en) | 2015-02-05 | 2021-08-04 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant comprising a modified fcrn-binding domain |
| SMT202500263T1 (it) | 2015-09-15 | 2025-09-12 | Scholar Rock Inc | Anticorpi anti-pro-miostatina/miostatina latente e loro usi |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| SG11201805709RA (en) | 2016-01-08 | 2018-07-30 | Scholar Rock Inc | Anti-pro/latent myostatin antibodies and methods of use thereof |
| EP3785728A3 (en) | 2016-06-13 | 2021-04-28 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
| MY193497A (en) * | 2016-06-17 | 2022-10-17 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies and methods of use |
| CN116251182A (zh) | 2016-08-05 | 2023-06-13 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| US11857599B2 (en) | 2017-04-03 | 2024-01-02 | Acceleron Pharma Inc. | Compositions and methods for treating spinal muscular atrophy |
| SG10202002990XA (en) | 2017-08-04 | 2020-05-28 | Skyhawk Therapeutics Inc | Methods and compositions for modulating splicing |
| WO2019170930A1 (es) * | 2018-03-09 | 2019-09-12 | Universitat De Lleida | Tratamiento para la atrofia muscular espinal |
| WO2019204369A1 (en) * | 2018-04-17 | 2019-10-24 | Applied Stemcell, Inc. | Compositions and methods for treating spinal muscular atrophy |
| SG11202108099WA (en) | 2019-01-30 | 2021-08-30 | Scholar Rock Inc | LTBP COMPLEX-SPECIFIC INHIBITORS OF TGFβ AND USES THEREOF |
| KR20210135241A (ko) | 2019-02-05 | 2021-11-12 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| KR20210135507A (ko) | 2019-02-06 | 2021-11-15 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| JP2022537266A (ja) * | 2019-06-19 | 2022-08-25 | エフ．ホフマン－ラ ロシュ アーゲー | デジタルバイオマーカー |
| EP3987543A1 (en) * | 2019-06-19 | 2022-04-27 | F. Hoffmann-La Roche AG | Digital biomarker |
| US11918570B2 (en) | 2020-04-13 | 2024-03-05 | The Research Foundation For The State University Of New York | Method of treatment for prevention of glucocorticoid toxicity and/or enhancement of muscle regeneration via neutrophil elastase inhibition |
| JP2023549455A (ja) * | 2020-10-26 | 2023-11-27 | スカラー ロック インコーポレイテッド | 脊髄性筋萎縮症を治療するための抗プロミオスタチン／抗潜在型ミオスタチン抗体の使用 |
| MX2023014840A (es) | 2021-06-23 | 2024-02-12 | Scholar Rock Inc | Un inhibidor de la vía de la miostatina en combinación con un activador de la vía de la glp-1 para su uso en el tratamiento de trastornos metabólicos. |
| WO2023288277A1 (en) | 2021-07-14 | 2023-01-19 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgfb1 and uses thereof |
| EP4426306A1 (en) * | 2021-10-06 | 2024-09-11 | F. Hoffmann-La Roche AG | Novel combined administration |
| IL316463A (en) * | 2022-05-04 | 2024-12-01 | Scholar Rock Inc | Using a myostatin inhibitor to treat spinal muscular atrophy |
| WO2024138076A1 (en) | 2022-12-22 | 2024-06-27 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
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|---|---|---|---|---|
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| DE69233745D1 (de) | 1991-12-02 | 2008-10-23 | Cambridge Antibody Tech | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
| WO1994021681A1 (en) | 1993-03-19 | 1994-09-29 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| CA2194660C (en) | 1994-07-08 | 2009-09-29 | Se-Jin Lee | Growth differentiation factor-11 |
| US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| PT2275449T (pt) | 2000-06-16 | 2016-12-27 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
| AU2011244851A1 (en) | 2000-07-27 | 2011-11-24 | The John Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| DE60128914T2 (de) | 2001-10-05 | 2008-05-08 | Affimed Therapeutics Ag | Antikörper menschlichen Ursprungs zur Hemmung der Thrombozytenaggregation |
| US8455627B2 (en) | 2001-10-05 | 2013-06-04 | Affimed Therapeutics, Ag | Human antibody specific for activated state of platelet integrin receptor GPIIb/IIIa |
| US20040044063A1 (en) | 2002-05-31 | 2004-03-04 | Brent Stockwell | SMA therapy and cell based assay for identifying therapies |
| MY151032A (en) | 2002-07-19 | 2014-03-31 | Abbott Lab S A | Treatment of tnf? related disorders |
| EP2192129A1 (en) | 2002-09-16 | 2010-06-02 | Johns Hopkins University | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
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| EP3006039B1 (en) | 2004-03-02 | 2021-01-06 | Acceleron Pharma Inc. | Alk7 polypeptides for use in promoting fat loss |
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| SMT202500263T1 (it) | 2015-09-15 | 2025-09-12 | Scholar Rock Inc | Anticorpi anti-pro-miostatina/miostatina latente e loro usi |
| SG11201805709RA (en) | 2016-01-08 | 2018-07-30 | Scholar Rock Inc | Anti-pro/latent myostatin antibodies and methods of use thereof |
| EP3785728A3 (en) | 2016-06-13 | 2021-04-28 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
| JOP20190152A1 (ar) | 2016-12-21 | 2019-06-20 | Novartis Ag | مضادات الميوستاتين، الآكتيفين أو مستقبلات الآكتيفين للاستخدام في علاج السمنة والحالات ذات الصلة |
-
2017
- 2017-06-13 EP EP20179533.3A patent/EP3785728A3/en active Pending
- 2017-06-13 EP EP23157280.1A patent/EP4218804A3/en active Pending
- 2017-06-13 RS RS20201327A patent/RS61090B1/sr unknown
- 2017-06-13 PE PE2018003207A patent/PE20190205A1/es unknown
- 2017-06-13 KR KR1020197000822A patent/KR102271635B1/ko active Active
- 2017-06-13 PT PT177320017T patent/PT3368069T/pt unknown
- 2017-06-13 AU AU2017283546A patent/AU2017283546C1/en active Active
- 2017-06-13 MY MYPI2018002494A patent/MY185614A/en unknown
- 2017-06-13 KR KR1020237005734A patent/KR20230028813A/ko not_active Ceased
- 2017-06-13 WO PCT/US2017/037332 patent/WO2017218592A1/en not_active Ceased
- 2017-06-13 SI SI201730485T patent/SI3368069T1/sl unknown
- 2017-06-13 KR KR1020217019817A patent/KR20210082548A/ko not_active Ceased
- 2017-06-13 HU HUE17732001A patent/HUE051480T2/hu unknown
- 2017-06-13 MY MYPI2020004682A patent/MY199499A/en unknown
- 2017-06-13 LT LTEP17732001.7T patent/LT3368069T/lt unknown
- 2017-06-13 US US16/308,007 patent/US10946036B2/en active Active
- 2017-06-13 HR HRP20201764TT patent/HRP20201764T1/hr unknown
- 2017-06-13 DK DK17732001.7T patent/DK3368069T3/da active
- 2017-06-13 SM SM20200598T patent/SMT202000598T1/it unknown
- 2017-06-13 EP EP17732001.7A patent/EP3368069B1/en active Active
- 2017-06-13 KR KR1020237042111A patent/KR20230169484A/ko not_active Ceased
- 2017-06-13 IL IL301468A patent/IL301468A/en unknown
- 2017-06-13 JP JP2019517209A patent/JP6823167B2/ja active Active
- 2017-06-13 ES ES17732001T patent/ES2830440T3/es active Active
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2018
- 2018-12-05 IL IL263510A patent/IL263510A/en unknown
- 2018-12-13 CL CL2018003588A patent/CL2018003588A1/es unknown
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2020
- 2020-07-27 AU AU2020210134A patent/AU2020210134B2/en active Active
- 2020-11-03 CY CY20201101038T patent/CY1123678T1/el unknown
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2021
- 2021-01-05 JP JP2021000367A patent/JP7161554B2/ja active Active
- 2021-02-03 US US17/248,700 patent/US20210283166A1/en active Pending
- 2021-11-04 AU AU2021261907A patent/AU2021261907B2/en active Active
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2022
- 2022-04-08 JP JP2022064360A patent/JP7344337B2/ja active Active
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2023
- 2023-09-01 JP JP2023142275A patent/JP2023164920A/ja active Pending
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2024
- 2024-05-22 AU AU2024203412A patent/AU2024203412A1/en active Pending
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