JP6696899B2 - プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用 - Google Patents

プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用 Download PDF

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JP6696899B2
JP6696899B2 JP2016534815A JP2016534815A JP6696899B2 JP 6696899 B2 JP6696899 B2 JP 6696899B2 JP 2016534815 A JP2016534815 A JP 2016534815A JP 2016534815 A JP2016534815 A JP 2016534815A JP 6696899 B2 JP6696899 B2 JP 6696899B2
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seq
pai
heavy chain
light chain
variable region
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JP2016529255A5 (enExample
JP2016529255A (ja
Inventor
アラ・プリッツカー
パトリック・グライエ
アレクセイ・ラク
マガリ・マチュー
クリストファー・ライアン・モーガン
ニコラ・ボラン
ブリュノ・ポワリ
シリル・デイブ
フランシス・ドゥフィユー
ハン・リー
ドロシア・コミノス
フィリップ・ジャニャク
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Sanofi SA
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Sanofi SA
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Priority claimed from PCT/US2014/050896 external-priority patent/WO2015023752A1/en
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Publication of JP2016529255A5 publication Critical patent/JP2016529255A5/ja
Priority to JP2020076578A priority Critical patent/JP6907380B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Microbiology (AREA)
JP2016534815A 2013-08-13 2014-08-13 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用 Active JP6696899B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020076578A JP6907380B2 (ja) 2013-08-13 2020-04-23 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361865451P 2013-08-13 2013-08-13
US61/865,451 2013-08-13
EP14305757 2014-05-22
EP14305757.8 2014-05-22
PCT/US2014/050896 WO2015023752A1 (en) 2013-08-13 2014-08-13 Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof

Related Child Applications (1)

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JP2020076578A Division JP6907380B2 (ja) 2013-08-13 2020-04-23 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用

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JP2016529255A JP2016529255A (ja) 2016-09-23
JP2016529255A5 JP2016529255A5 (enExample) 2018-06-28
JP6696899B2 true JP6696899B2 (ja) 2020-05-20

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JP2016534815A Active JP6696899B2 (ja) 2013-08-13 2014-08-13 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用
JP2020076578A Active JP6907380B2 (ja) 2013-08-13 2020-04-23 プラスミノーゲン活性化因子阻害剤−１（ｐａｉ−１）に対する抗体及びその使用
JP2021107196A Active JP7223069B2 (ja) 2013-08-13 2021-06-29 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2023014335A Active JP7568756B2 (ja) 2013-08-13 2023-02-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2024172861A Active JP7764565B2 (ja) 2013-08-13 2024-10-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用

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JP2021107196A Active JP7223069B2 (ja) 2013-08-13 2021-06-29 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2023014335A Active JP7568756B2 (ja) 2013-08-13 2023-02-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用
JP2024172861A Active JP7764565B2 (ja) 2013-08-13 2024-10-02 プラスミノーゲン活性化因子阻害剤－１（ｐａｉ－１）に対する抗体及びその使用

Country Status (17)

Country Link
US (4) US9845363B2 (enExample)
JP (5) JP6696899B2 (enExample)
KR (1) KR20160035077A (enExample)
CN (2) CN112142845A (enExample)
BR (1) BR112016002753A2 (enExample)
CL (1) CL2016000324A1 (enExample)
CR (2) CR20190319A (enExample)
DO (1) DOP2016000042A (enExample)
EA (1) EA033403B1 (enExample)
ES (1) ES2770507T3 (enExample)
HK (1) HK1221725A1 (enExample)
MX (2) MX2016001851A (enExample)
PE (1) PE20160244A1 (enExample)
PH (1) PH12016500239A1 (enExample)
SG (1) SG10201710013RA (enExample)
TN (1) TN2016000048A1 (enExample)
UA (1) UA118267C2 (enExample)

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JP2019500426A (ja) 2015-12-18 2019-01-10 タレンゲン インターナショナル リミティッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 糖尿病網膜症を予防または治療するための方法
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US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
TW201822797A (zh) * 2016-12-15 2018-07-01 深圳瑞健生命科學研究院有限公司 一種預防和治療腎纖維化的方法
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JP7616697B2 (ja) * 2020-02-11 2025-01-17 タレンゲン インターナショナル リミテッド ウイルス性肺炎を治療する方法及び薬剤
CN111072780B (zh) * 2020-03-24 2020-06-23 深圳汉盛汇融再生医学科技有限公司 白血病干细胞抑制剂及其在治疗慢性粒细胞白血病中的应用
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CN114605550B (zh) * 2020-12-08 2023-09-22 东莞市朋志生物科技有限公司 抗ca19-9的抗体、其应用和检测ca19-9的试剂盒
CN114686441B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 一种能分泌tPAI-C单克隆抗体的杂交瘤细胞株及其应用
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