CN101809034B - C3b抗体及用于预防和治疗补体相关病症的方法 - Google Patents

C3b抗体及用于预防和治疗补体相关病症的方法 Download PDF

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CN101809034B
CN101809034B CN200880102282.9A CN200880102282A CN101809034B CN 101809034 B CN101809034 B CN 101809034B CN 200880102282 A CN200880102282 A CN 200880102282A CN 101809034 B CN101809034 B CN 101809034B
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antibody
sequence
complement
amino acid
val
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CN101809034A (zh
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门诺·范卢克伦坎帕格尼
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Genentech Inc
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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CN200880102282.9A 2007-06-07 2008-06-04 C3b抗体及用于预防和治疗补体相关病症的方法 Expired - Fee Related CN101809034B (zh)

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Application Number Priority Date Filing Date Title
US93372107P 2007-06-07 2007-06-07
US60/933,721 2007-06-07
US5506808P 2008-05-21 2008-05-21
US60/055,068 2008-05-21
PCT/US2008/065771 WO2008154251A2 (en) 2007-06-07 2008-06-04 C3b antibodies and methods for the prevention and treatment of complement- associated disorders

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CN101809034A CN101809034A (zh) 2010-08-18
CN101809034B true CN101809034B (zh) 2015-07-08

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US (2) US8012473B2 (enExample)
EP (1) EP2162470A2 (enExample)
JP (3) JP5683265B2 (enExample)
KR (3) KR20170023212A (enExample)
CN (1) CN101809034B (enExample)
AR (1) AR066916A1 (enExample)
AU (1) AU2008262048B2 (enExample)
BR (1) BRPI0812767A2 (enExample)
CA (1) CA2690124A1 (enExample)
CL (1) CL2008001656A1 (enExample)
IL (1) IL201820A0 (enExample)
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PE (1) PE20090416A1 (enExample)
RU (1) RU2473563C2 (enExample)
SG (2) SG10201608952QA (enExample)
TW (2) TWI441832B (enExample)
WO (1) WO2008154251A2 (enExample)
ZA (1) ZA200907575B (enExample)

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