JP2017536341A5 - - Google Patents

Download PDF

Info

Publication number
JP2017536341A5
JP2017536341A5 JP2017518516A JP2017518516A JP2017536341A5 JP 2017536341 A5 JP2017536341 A5 JP 2017536341A5 JP 2017518516 A JP2017518516 A JP 2017518516A JP 2017518516 A JP2017518516 A JP 2017518516A JP 2017536341 A5 JP2017536341 A5 JP 2017536341A5
Authority
JP
Japan
Prior art keywords
antibody
ror1
domain
fab
bispecific antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017518516A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017536341A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2015/073309 external-priority patent/WO2016055593A1/en
Publication of JP2017536341A publication Critical patent/JP2017536341A/ja
Publication of JP2017536341A5 publication Critical patent/JP2017536341A5/ja
Pending legal-status Critical Current

Links

JP2017518516A 2014-10-09 2015-10-08 卵巣がんの処置における使用のためのCD3εおよびROR1に対する二特異性抗体 Pending JP2017536341A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP14188378.5 2014-10-09
EP14188378 2014-10-09
EP14188728.1 2014-10-14
EP14188727.3 2014-10-14
EP14188728 2014-10-14
EP14188727 2014-10-14
PCT/EP2015/073309 WO2016055593A1 (en) 2014-10-09 2015-10-08 Bispecific antibodies against cd3epsilon and ror1 for use in the treatment of ovarian cancer

Publications (2)

Publication Number Publication Date
JP2017536341A JP2017536341A (ja) 2017-12-07
JP2017536341A5 true JP2017536341A5 (enExample) 2018-11-22

Family

ID=54291293

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017518516A Pending JP2017536341A (ja) 2014-10-09 2015-10-08 卵巣がんの処置における使用のためのCD3εおよびROR1に対する二特異性抗体

Country Status (6)

Country Link
US (1) US20170306044A1 (enExample)
EP (1) EP3204416A1 (enExample)
JP (1) JP2017536341A (enExample)
AU (1) AU2015329966A1 (enExample)
CA (1) CA2963696A1 (enExample)
WO (1) WO2016055593A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6400470B2 (ja) 2011-05-16 2018-10-03 ジェネロン(シャンハイ)コーポレイション リミテッド 多重特異性Fab融合タンパク質および使用法
KR101870555B1 (ko) 2011-08-23 2018-06-22 로슈 글리카트 아게 T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법
MX2015003616A (es) 2012-10-08 2015-06-05 Roche Glycart Ag Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de uso.
CN110437337B (zh) 2013-02-26 2024-07-30 罗切格利卡特公司 双特异性t细胞活化性抗原结合分子
EP2789630A1 (en) * 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
PL3177643T3 (pl) 2014-08-04 2019-09-30 F.Hoffmann-La Roche Ag Dwuswoiste cząsteczki wiążące antygen aktywujące komórki T
RS61010B1 (sr) 2014-11-20 2020-11-30 Hoffmann La Roche Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije protiv folr1 i cd3
SG11201704056XA (en) 2014-11-20 2017-06-29 Hoffmann La Roche Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists
ES2808853T3 (es) 2014-11-20 2021-03-02 Hoffmann La Roche Cadenas ligeras comunes y procedimientos de uso
CA2992797A1 (en) 2015-08-03 2017-02-09 Engmab Sarl Monoclonal antibodies against bcma
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
JP7044700B2 (ja) 2015-10-02 2022-03-30 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ceaxcd3 t細胞活性化抗原結合分子
CA3001941A1 (en) 2015-10-30 2017-05-04 Nbe-Therapeutics Ag Anti-ror1 antibodies
IL313608A (en) 2015-12-09 2024-08-01 Hoffmann La Roche Antibody against CD20 type II to reduce the formation of antibodies against drugs
BR112018011029A2 (pt) 2016-01-08 2018-11-21 Hoffmann La Roche métodos para tratar ou atrasar a progressão do câncer e para melhorar a função imune em um indivíduo com câncer, usos de um antagonista de ligação e de um anticorpo biespecífico, composições e kits
MX2018008926A (es) 2016-01-20 2019-01-10 Scripps Research Inst Composiciones de anticuerpo contra ror1 y métodos relacionados.
WO2017157305A1 (en) 2016-03-15 2017-09-21 Generon (Shanghai) Corporation Ltd. Multispecific fab fusion proteins and use thereof
JP7015244B2 (ja) 2016-03-22 2022-02-02 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト プロテアーゼ活性化t細胞二重特異性分子
CN109843926B (zh) * 2016-09-30 2023-01-20 豪夫迈·罗氏有限公司 针对cd3的双特异性抗体
MY200973A (en) * 2017-04-11 2024-01-26 Inhibrx Inc Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same
TWI804499B (zh) 2017-06-23 2023-06-11 美商維洛斯生物公司 Ror1抗體免疫接合物
GB201710835D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Antibodies
GB201710838D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies
GB201710836D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Car T-Cells
US20210139579A1 (en) * 2017-07-20 2021-05-13 Nbe-Therapeutics Ag Multispecific antibody product that binds to different ror1 epitopes
KR20230008269A (ko) 2017-08-07 2023-01-13 엔비이-테라퓨틱스 아게 생체 내 내성이 높은 항체 약물 결합체
CN107827984B (zh) * 2017-09-13 2021-03-16 张慧林 嵌合抗ROR1抗体Fab分子及其制备方法和应用
GB201721802D0 (en) * 2017-12-22 2018-02-07 Almac Discovery Ltd Ror1-specific antigen binding molecules
CR20200391A (es) 2018-02-08 2020-10-19 Genentech Inc Moléculas biespecíficas de unión al antígeno y métodos de uso
TWI829667B (zh) * 2018-02-09 2024-01-21 瑞士商赫孚孟拉羅股份公司 結合gprc5d之抗體
CA3094318A1 (en) 2018-03-30 2019-10-03 Merus N.V. Multivalent antibody
TW202010757A (zh) 2018-04-11 2020-03-16 美商英伊布里克斯公司 具有經受限cd3結合的多重特異性多肽構築體以及相關方法及用途
KR102999339B1 (ko) * 2018-04-18 2026-07-31 엑셀리시스, 인코포레이티드 항-ror 항체 구조체
WO2020023553A1 (en) 2018-07-24 2020-01-30 Inhibrx, Inc. Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
JP7611820B2 (ja) 2018-10-11 2025-01-10 インヒブルクス バイオサイエンシズ インコーポレイテッド Dll3シングルドメイン抗体およびその治療用組成物
US12590169B2 (en) 2018-10-11 2026-03-31 Inhibrx Biosciences, Inc. 5T4 single domain antibodies and therapeutic compositions thereof
WO2020132810A1 (en) 2018-12-24 2020-07-02 Generon (Shanghai) Corporation Ltd. Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof
KR20220024637A (ko) * 2019-06-19 2022-03-03 에프. 호프만-라 로슈 아게 정의된 조직의 다수 발현 카세트들의 표적화 통합에 의한 3가 항체 발현 세포의 생성 방법
JP2022543553A (ja) * 2019-07-31 2022-10-13 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Gprc5dに結合する抗体
EP4097129A1 (en) 2020-01-29 2022-12-07 Inhibrx, Inc. Cd28 single domain antibodies and multivalent and multispecific constructs thereof
CR20220637A (es) 2020-06-19 2023-01-31 Hoffmann La Roche Anticuerpos que se unen a cd3 y cd19
IL300760A (en) * 2020-08-24 2023-04-01 Epimab Biotherapeutics Hk Ltd Anti-ROR1 antibodies and related bispecific binding proteins
EP3988568A1 (en) * 2020-10-21 2022-04-27 Numab Therapeutics AG Combination treatment
WO2022146003A1 (ko) * 2020-12-29 2022-07-07 삼성바이오로직스 주식회사 이중 또는 다중 특이적 항체
JP7858665B2 (ja) * 2021-02-02 2026-05-14 ヌマブ セラピューティックス アーゲー Ror1およびcd3に対する特異性を有する多重特異性抗体
CA3213632A1 (en) 2021-04-30 2022-11-03 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
EP4384218A4 (en) * 2021-08-09 2025-11-05 Merck Patent Gmbh Proteins that uncouple T-lymphocyte-mediated tumor cytotoxicity from the release of pro-inflammatory cytokines
CN120897932A (zh) * 2023-02-23 2025-11-04 阿达纳特股份有限公司 抗cd3抗体及其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101837053B1 (ko) * 2008-10-01 2018-03-12 암젠 리서치 (뮌헨) 게엠베하 종간 특이적 PSCAxCD3, CD19xCD3, c-METxCD3, 엔도시알린xCD3, EpCAMxCD3, IGF-1RxCD3 또는 FAPαxCD3 이중특이적 단일쇄 항체
WO2011054007A1 (en) * 2009-11-02 2011-05-05 Oxford Biotherapeutics Ltd. Ror1 as therapeutic and diagnostic target
US9228023B2 (en) * 2010-10-01 2016-01-05 Oxford Biotherapeutics Ltd. Anti-ROR1 antibodies and methods of use for treatment of cancer
EP2646469B1 (en) * 2010-12-01 2017-11-01 The United States of America, as represented by The Secretary, Department of Health and Human Services Chimeric rabbit/human ror1 antibodies
WO2013026837A1 (en) * 2011-08-23 2013-02-28 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
BR112014010257A2 (pt) * 2011-10-31 2017-04-18 Chugai Pharmaceutical Co Ltd molécula de ligação ao antígeno tendo conjugação regulada entre cadeias pesadas e cadeias leves
TWI679212B (zh) * 2011-11-15 2019-12-11 美商安進股份有限公司 針對bcma之e3以及cd3的結合分子
MX2014014162A (es) * 2012-05-24 2015-02-04 Hoffmann La Roche Anticuerpos multiespecificos.
MX2015003616A (es) * 2012-10-08 2015-06-05 Roche Glycart Ag Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de uso.
CN110437337B (zh) * 2013-02-26 2024-07-30 罗切格利卡特公司 双特异性t细胞活化性抗原结合分子
US20160017058A1 (en) * 2013-03-14 2016-01-21 The California Institute For Biomedical Research Bispecific antibodies and uses thereof
WO2014151910A1 (en) * 2013-03-15 2014-09-25 Amgen Inc. Heterodimeric bispecific antibodies
EP2789630A1 (en) * 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1

Similar Documents

Publication Publication Date Title
TWI767899B (zh) Psma及cd3雙特異性t細胞嚙合抗體構築體
US20230348584A1 (en) Use of anti-fam19a5 antibodies for treating cancers
JP2022068161A (ja) 新規抗pd-l1抗体
RU2363706C2 (ru) Антитела к рецептору инсулиноподобного фактора роста i и их применение
JP6767362B2 (ja) リンパ球における阻害経路の中和
EP3702373B9 (en) Anti-pd1 antibodies and their use as therapeutics and diagnostics
US20240209078A1 (en) Multitargeting bispecific antigen-binding molecules of increased selectivity
JP2021527431A5 (enExample)
JP2018502050A5 (enExample)
AU2020363041B2 (en) Antibodies against the poliovirus receptor (PVR) and uses thereof
RU2019134352A (ru) Новые биспецифические антигенсвязывающие молекулы, обладающие способностью специфически связываться с cd40 и fap
JP2022513420A5 (enExample)
JP2020516240A5 (enExample)
RU2012142231A (ru) Антитела против csf-1r человека и их применение
JP2011509245A5 (enExample)
JP2025508118A (ja) 新規免疫調節剤の開発および使用
JP7802858B2 (ja) チェックポイント分子に対する多重特異性結合性構築物およびその使用
KR20160131061A (ko) 항-mcam 항체 및 관련된 사용 방법
TW202214303A (zh) 用於癌症治療之結合分子
TW202313683A (zh) 抗nkg2a抗體及組合物
JP2022517216A5 (enExample)
CN113574069A (zh) 抗pd-l1抗体及其用途
AU2023329054A1 (en) Combination cancer treatment comprising an anti-msln/cd137 antibody and pd-1/pd-l1 inhibitor
HK40106092A (en) Anti-nkg2a antibodies and compositions
WO2022268168A1 (zh) 靶向lag-3和pd-l1的新型双特异抗体及其应用