CA2963696A1 - Bispecific antibodies against cd3epsilon and ror1 for use in the treatment of ovarian cancer - Google Patents
Bispecific antibodies against cd3epsilon and ror1 for use in the treatment of ovarian cancer Download PDFInfo
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- CA2963696A1 CA2963696A1 CA2963696A CA2963696A CA2963696A1 CA 2963696 A1 CA2963696 A1 CA 2963696A1 CA 2963696 A CA2963696 A CA 2963696A CA 2963696 A CA2963696 A CA 2963696A CA 2963696 A1 CA2963696 A1 CA 2963696A1
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Applications Claiming Priority (7)
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| EP14188728.1 | 2014-10-14 | ||
| EP14188727 | 2014-10-14 | ||
| PCT/EP2015/073309 WO2016055593A1 (en) | 2014-10-09 | 2015-10-08 | Bispecific antibodies against cd3epsilon and ror1 for use in the treatment of ovarian cancer |
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| WO (1) | WO2016055593A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107827984A (zh) * | 2017-09-13 | 2018-03-23 | 张慧林 | 嵌合抗ROR1抗体Fab分子及其制备方法和应用 |
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| JP6400470B2 (ja) | 2011-05-16 | 2018-10-03 | ジェネロン（シャンハイ）コーポレイション リミテッド | 多重特異性Ｆａｂ融合タンパク質および使用法 |
| WO2013026839A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| BR112015007120A2 (pt) | 2012-10-08 | 2017-12-12 | Roche Glycart Ag | anticorpo biespecífico, composição farmacêutica, uso, célula hospedeira e método de produção de um anticorpo |
| PT2961771T (pt) | 2013-02-26 | 2020-02-28 | Roche Glycart Ag | Moléculas de ligação ao antigénio biespecíficas para ativação das células t, específicas para cd3 e cea |
| EP2789630A1 (en) * | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| FI3608337T3 (fi) | 2014-08-04 | 2024-06-13 | Hoffmann La Roche | Bispesifisiä t-solua aktivoivia antigeenia sitovia molekyylejä |
| CN107074955B (zh) | 2014-11-20 | 2021-06-22 | 豪夫迈·罗氏有限公司 | 针对FolR1和CD3的T细胞活化性双特异性抗原结合分子 |
| MX387463B (es) | 2014-11-20 | 2025-03-18 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas activadoras de células t y antagonistas de unión al eje de pd-1 y usos de los mismos para el tratamiento de cáncer. |
| RS60615B1 (sr) | 2014-11-20 | 2020-08-31 | Hoffmann La Roche | Zajednički laki lanci i postupci upotrebe |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| MA43025A (fr) | 2015-10-02 | 2021-05-26 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t anti-ceaxcd3 |
| SG11201803098VA (en) | 2015-10-30 | 2018-05-30 | Nbe Therapeutics Ag | Anti-ror1 antibodies |
| CA2997406C (en) | 2015-12-09 | 2024-05-28 | F. Hoffmann-La Roche Ag | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies or cytokine release |
| BR112018011029A2 (pt) | 2016-01-08 | 2018-11-21 | Hoffmann La Roche | métodos para tratar ou atrasar a progressão do câncer e para melhorar a função imune em um indivíduo com câncer, usos de um antagonista de ligação e de um anticorpo biespecífico, composições e kits |
| JP7000660B2 (ja) | 2016-01-20 | 2022-02-04 | ザ スクリプス リサーチ インスティテュート | Ｒｏｒ１抗体組成物及び関連の方法 |
| US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
| MY198233A (en) | 2016-03-22 | 2023-08-15 | Hoffmann La Roche | Protease-Activated T Cell Bispecific Molecules |
| PL3519437T3 (pl) * | 2016-09-30 | 2022-01-17 | F. Hoffmann-La Roche Ag | Przeciwciała dwuswoiste przeciwko p95HER2 |
| CN110770255B (zh) | 2017-04-11 | 2025-07-01 | 因荷布瑞克斯生物科学公司 | 具有受限cd3结合的多特异性多肽构建体及其使用方法 |
| MX2019015057A (es) | 2017-06-23 | 2020-08-03 | Velosbio Inc | Inmunoconjugados de anticuerpos receptor huérfano similar al receptor tirosina cinasa 1 (ror1). |
| GB201710836D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Car T-Cells |
| GB201710835D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Antibodies |
| GB201710838D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | Bispecific antibodies |
| US20210139579A1 (en) * | 2017-07-20 | 2021-05-13 | Nbe-Therapeutics Ag | Multispecific antibody product that binds to different ror1 epitopes |
| CA3071212C (en) | 2017-08-07 | 2023-12-12 | Nbe-Therapeutics Ag | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| GB201721802D0 (en) * | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| SG11202007390YA (en) | 2018-02-08 | 2020-08-28 | Genentech Inc | Bispecific antigen-binding molecules and methods of use |
| TWI829667B (zh) * | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
| SG11202009036YA (en) | 2018-03-30 | 2020-10-29 | Merus Nv | Multivalent antibody |
| SG11202009804RA (en) | 2018-04-11 | 2020-11-27 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| CN112384533A (zh) | 2018-04-18 | 2021-02-19 | 埃克塞里艾克西斯公司 | 抗-ror抗体构建体 |
| WO2020023553A1 (en) | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| EP3847196A4 (en) * | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| TWI863932B (zh) * | 2018-10-11 | 2024-12-01 | 美商因荷布瑞克斯生物科學公司 | 5t4單域抗體及其治療性組合物 |
| TW202028245A (zh) | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | Dll3單域抗體及其治療性組合物 |
| KR20220024637A (ko) * | 2019-06-19 | 2022-03-03 | 에프. 호프만-라 로슈 아게 | 정의된 조직의 다수 발현 카세트들의 표적화 통합에 의한 3가 항체 발현 세포의 생성 방법 |
| MY206610A (en) * | 2019-07-31 | 2024-12-26 | Hoffmann La Roche | Antibodies binding to gprc5d |
| CN115380047A (zh) | 2020-01-29 | 2022-11-22 | 印希比股份有限公司 | Cd28单结构域抗体及其多价和多特异性构建体 |
| US11780920B2 (en) | 2020-06-19 | 2023-10-10 | Hoffmann-La Roche Inc. | Antibodies binding to CD3 and CD19 |
| BR112023002895A2 (pt) * | 2020-08-24 | 2023-03-21 | Epimab Biotherapeutics Hk Ltd | Anticorpos anti-ror1 e proteínas de ligação biespecíficas relacionadas |
| EP3988568A1 (en) * | 2020-10-21 | 2022-04-27 | Numab Therapeutics AG | Combination treatment |
| JP2024502095A (ja) * | 2020-12-29 | 2024-01-17 | サムソン バイオロジクス カンパニー リミテッド | 二重または多重特異性抗体｛Ｂｉ ｏｒ Ｍｕｌｔｉ－Ｓｐｅｃｉｆｉｃ Ａｎｔｉｂｏｄｙ｝ |
| PE20250740A1 (es) * | 2021-02-02 | 2025-03-13 | Numab Therapeutics AG | Anticuerpos multiespecificos con especificidad para ror1 y cd3 |
| KR20240005691A (ko) | 2021-04-30 | 2024-01-12 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이적 항체 및 항-cd79b 항체 약물 접합체를 이용한 병용 치료를 위한 투약 |
| IL322923A (en) * | 2023-02-23 | 2025-10-01 | Adanate Inc | Anti-CD3 antibodies and methods of using them |
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| BRPI0919840B1 (pt) * | 2008-10-01 | 2023-02-28 | Amgen Research (Munich) Gmbh | Molécula de anticorpo de cadeia única biespecífica, seu uso, e composição farmacêutica que a compreende |
| WO2011054007A1 (en) * | 2009-11-02 | 2011-05-05 | Oxford Biotherapeutics Ltd. | Ror1 as therapeutic and diagnostic target |
| EP3219731A1 (en) * | 2010-10-01 | 2017-09-20 | Oxford BioTherapeutics Ltd | Anti-ror1 antibodies |
| WO2012075158A1 (en) * | 2010-12-01 | 2012-06-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric rabbit/human ror1 antibodies |
| US20130078250A1 (en) * | 2011-08-23 | 2013-03-28 | Oliver Ast | Bispecific t cell activating antigen binding molecules |
| US11851476B2 (en) * | 2011-10-31 | 2023-12-26 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
| TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| WO2013174873A1 (en) * | 2012-05-24 | 2013-11-28 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
| BR112015007120A2 (pt) * | 2012-10-08 | 2017-12-12 | Roche Glycart Ag | anticorpo biespecífico, composição farmacêutica, uso, célula hospedeira e método de produção de um anticorpo |
| PT2961771T (pt) * | 2013-02-26 | 2020-02-28 | Roche Glycart Ag | Moléculas de ligação ao antigénio biespecíficas para ativação das células t, específicas para cd3 e cea |
| ES2790420T3 (es) * | 2013-03-14 | 2020-10-27 | Scripps Research Inst | Conjugados de anticuerpos y de agentes de focalización usos de los mismos |
| EP2970484B2 (en) * | 2013-03-15 | 2022-09-21 | Amgen Inc. | Heterodimeric bispecific antibodies |
| EP2789630A1 (en) * | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
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- 2015-10-08 CA CA2963696A patent/CA2963696A1/en not_active Abandoned
- 2015-10-08 WO PCT/EP2015/073309 patent/WO2016055593A1/en not_active Ceased
- 2015-10-08 AU AU2015329966A patent/AU2015329966A1/en not_active Abandoned
- 2015-10-08 US US15/517,329 patent/US20170306044A1/en not_active Abandoned
- 2015-10-08 EP EP15778295.4A patent/EP3204416A1/en not_active Withdrawn
- 2015-10-08 JP JP2017518516A patent/JP2017536341A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107827984A (zh) * | 2017-09-13 | 2018-03-23 | 张慧林 | 嵌合抗ROR1抗体Fab分子及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017536341A (ja) | 2017-12-07 |
| WO2016055593A1 (en) | 2016-04-14 |
| US20170306044A1 (en) | 2017-10-26 |
| AU2015329966A1 (en) | 2017-04-27 |
| EP3204416A1 (en) | 2017-08-16 |
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