JP2019527543A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019527543A5 JP2019527543A5 JP2018567611A JP2018567611A JP2019527543A5 JP 2019527543 A5 JP2019527543 A5 JP 2019527543A5 JP 2018567611 A JP2018567611 A JP 2018567611A JP 2018567611 A JP2018567611 A JP 2018567611A JP 2019527543 A5 JP2019527543 A5 JP 2019527543A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- human
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims description 40
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 12
- 102000048362 human PDCD1 Human genes 0.000 claims description 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 5
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 5
- 238000004220 aggregation Methods 0.000 claims description 5
- 230000002776 aggregation Effects 0.000 claims description 5
- 238000010494 dissociation reaction Methods 0.000 claims description 4
- 230000005593 dissociations Effects 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 3
- 230000000771 oncological effect Effects 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 2
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 239000003981 vehicle Substances 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 230000016615 flocculation Effects 0.000 claims 1
- 238000005189 flocculation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2016128487A RU2656181C1 (ru) | 2016-07-13 | 2016-07-13 | Анти-pd-1-антитела, способ их получения и способ применения |
| RU2016128487 | 2016-07-13 | ||
| PCT/RU2017/050056 WO2018013017A1 (ru) | 2016-07-13 | 2017-07-04 | Анти-pd-1-антитела, способ их получения и способ применения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527543A JP2019527543A (ja) | 2019-10-03 |
| JP2019527543A5 true JP2019527543A5 (enExample) | 2020-08-13 |
| JP6993992B2 JP6993992B2 (ja) | 2022-01-14 |
Family
ID=60953256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567611A Active JP6993992B2 (ja) | 2016-07-13 | 2017-07-04 | 抗ｐｄ－１抗体、その産生方法及びその使用方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11136408B2 (enExample) |
| EP (1) | EP3486257A4 (enExample) |
| JP (1) | JP6993992B2 (enExample) |
| KR (1) | KR102482710B1 (enExample) |
| CN (1) | CN110023335B (enExample) |
| BR (1) | BR112019000436A2 (enExample) |
| CA (1) | CA3021372A1 (enExample) |
| CL (1) | CL2018003407A1 (enExample) |
| CO (1) | CO2019001246A2 (enExample) |
| CR (1) | CR20190009A (enExample) |
| EC (1) | ECSP19010852A (enExample) |
| JO (1) | JOP20190002A1 (enExample) |
| MA (1) | MA44547B1 (enExample) |
| MX (1) | MX2018014937A (enExample) |
| NI (1) | NI201900002A (enExample) |
| NZ (1) | NZ750221A (enExample) |
| PE (1) | PE20190450A1 (enExample) |
| PH (1) | PH12018550179A1 (enExample) |
| RU (1) | RU2656181C1 (enExample) |
| WO (1) | WO2018013017A1 (enExample) |
| ZA (1) | ZA201900792B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201911035QA (en) | 2015-11-18 | 2020-01-30 | Merck Sharp & Dohme | Pd1 and/or lag3 binders |
| AU2018209556C1 (en) | 2017-01-20 | 2020-10-15 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-PD-1 antibodies and uses thereof |
| AU2018252193B2 (en) | 2017-04-14 | 2024-12-12 | Tallac Therapeutics, Inc. | Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use |
| MX2019014577A (es) | 2017-06-05 | 2020-07-29 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1 y metodos de uso. |
| CA3071376A1 (en) | 2017-08-03 | 2019-02-07 | Amgen Inc. | Interleukin-21 muteins and methods of treatment |
| AU2019207895A1 (en) | 2018-01-12 | 2020-06-18 | Amgen Inc. | Anti-PD-1 antibodies and methods of treatment |
| WO2019148410A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1 antibodies |
| EP3823991A4 (en) * | 2018-07-19 | 2022-08-03 | Tayu Huaxia Biotech Medical Group Co., Ltd. | ANTI-PD-1 ANTIBODIES, DOSAGE FORMS AND USES THEREOF |
| CN109652453B (zh) * | 2018-12-29 | 2021-04-06 | 杭州科兴生物科技有限公司 | 一种基于pd-1/pdl-1阻断功能及生物效应的抗癌药物快速筛选方法 |
| CA3141531A1 (en) | 2019-05-24 | 2020-12-03 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| AU2020290971A1 (en) * | 2019-06-14 | 2021-12-23 | Dana-Farber Cancer Institute, Inc. | Antibodies against PD-1 and methods of use thereof |
| TWI844666B (zh) | 2019-08-22 | 2024-06-11 | 俄羅斯聯邦商拜奧卡德聯合股份公司 | 抗ＰＤ－１抗體Ｐｒｏｌｇｏｌｉｍａｂ的水性藥物組合物及其用途 |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| US11920136B2 (en) | 2020-02-28 | 2024-03-05 | Tallac Therapeutics, Inc. | Transglutaminase-mediated conjugation |
| LT4157876T (lt) | 2020-05-26 | 2024-10-25 | Boehringer Ingelheim International Gmbh | Anti-pd-1 antikūnai |
| WO2022118197A1 (en) | 2020-12-02 | 2022-06-09 | Pfizer Inc. | Time to resolution of axitinib-related adverse events |
| EP4261225A4 (en) * | 2020-12-10 | 2024-11-13 | Eutilex Co., Ltd. | ANTI-PD-1 ANTIBODY AND ITS USES |
| EP4314062A1 (en) * | 2021-03-31 | 2024-02-07 | Merus N.V. | Novel pd-1 binding domains |
| MX2023011952A (es) | 2021-04-08 | 2023-11-09 | Biocad Joint Stock Co | Metodo para tratar una neoplasia maligna mediante la combinacion de un anticuerpo contra pd-1 y un agente quimioterapeutico. |
| WO2023057882A1 (en) | 2021-10-05 | 2023-04-13 | Pfizer Inc. | Combinations of azalactam compounds with a pd-1 axis binding antagonist for the treatment of cancer |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| EP4598960A1 (en) * | 2022-10-05 | 2025-08-13 | Chulalongkorn University | Monoclonal antibodies against human programmed cell death protein 1 (pd-1) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109485727A (zh) * | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
| NZ600758A (en) * | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| US8062852B2 (en) * | 2007-10-01 | 2011-11-22 | The Children's Hospital And Regional Medical Center | Detection and treatment of autoimmune disorders |
| NZ599405A (en) * | 2009-11-24 | 2014-09-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| EP2545078A1 (en) * | 2010-03-11 | 2013-01-16 | UCB Pharma, S.A. | Pd-1 antibody |
| KR20160044598A (ko) * | 2011-03-29 | 2016-04-25 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
| HRP20210122T1 (hr) * | 2013-05-02 | 2021-04-16 | Anaptysbio, Inc. | Protutijela usmjerena protiv programirane smrti-1 (pd-1) |
| ES2792183T3 (es) * | 2013-09-13 | 2020-11-10 | Beigene Switzerland Gmbh | Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico |
| EP3177640B1 (en) * | 2014-08-08 | 2020-05-06 | The Board of Trustees of the Leland Stanford Junior University | High affinity pd-1 agents and methods of use |
| GB201419084D0 (en) * | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-PD-1 antibodies |
| TWI595006B (zh) * | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
-
2016
- 2016-07-13 RU RU2016128487A patent/RU2656181C1/ru active
-
2017
- 2017-06-16 JO JOP/2019/0002A patent/JOP20190002A1/ar unknown
- 2017-07-04 CR CR20190009A patent/CR20190009A/es unknown
- 2017-07-04 EP EP17828049.1A patent/EP3486257A4/en active Pending
- 2017-07-04 WO PCT/RU2017/050056 patent/WO2018013017A1/ru not_active Ceased
- 2017-07-04 NZ NZ750221A patent/NZ750221A/en unknown
- 2017-07-04 CA CA3021372A patent/CA3021372A1/en active Pending
- 2017-07-04 BR BR112019000436A patent/BR112019000436A2/pt unknown
- 2017-07-04 MX MX2018014937A patent/MX2018014937A/es unknown
- 2017-07-04 JP JP2018567611A patent/JP6993992B2/ja active Active
- 2017-07-04 CN CN201780055794.3A patent/CN110023335B/zh active Active
- 2017-07-04 KR KR1020197003862A patent/KR102482710B1/ko active Active
- 2017-07-04 US US16/095,800 patent/US11136408B2/en active Active
- 2017-07-04 MA MA44547A patent/MA44547B1/fr unknown
- 2017-07-04 PE PE2019000027A patent/PE20190450A1/es unknown
-
2018
- 2018-10-26 PH PH12018550179A patent/PH12018550179A1/en unknown
- 2018-11-29 CL CL2018003407A patent/CL2018003407A1/es unknown
-
2019
- 2019-01-08 NI NI201900002A patent/NI201900002A/es unknown
- 2019-02-07 ZA ZA2019/00792A patent/ZA201900792B/en unknown
- 2019-02-12 CO CONC2019/0001246A patent/CO2019001246A2/es unknown
- 2019-02-13 EC ECSENADI201910852A patent/ECSP19010852A/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019527543A5 (enExample) | ||
| JP6854266B2 (ja) | 抗体製剤および方法 | |
| TWI838621B (zh) | 具有經修飾重鏈恆定區之多特異性重鏈抗體 | |
| TW202208414A (zh) | April及baff抑制性免疫調節蛋白及其使用方法 | |
| JP2018510617A5 (enExample) | ||
| JP2023081303A (ja) | 重鎖定常領域が修飾された多重特異性重鎖抗体 | |
| AU2013305885A1 (en) | Molecules with antigen binding and polyvalent Fc gamma receptor binding activity | |
| JP2022517441A (ja) | Ｂｔｌａ抗体 | |
| US11034775B2 (en) | Cysteine-optimized stradomers | |
| CN111094339B (zh) | 抗pd-1抗体和抗lag-3抗体联合在制备治疗肿瘤的药物中的用途 | |
| US12195499B2 (en) | Manufacturing optimization of GL-2045, a multimerizing stradomer | |
| JP2024514107A (ja) | 抗ｃｄ１９抗体及びｃａｒ－ｔ構造体 | |
| JP2022517809A (ja) | Ｌｉｌｒｂ３結合分子とその使用 | |
| KR20210138674A (ko) | Tsg-6 항체 및 그 용도 | |
| JP2021518132A (ja) | Ｇｉｐｒ抗体及びｇｌｐ−１とのその融合タンパク質、並びにその医薬組成物及び用途 | |
| JP2025525535A (ja) | 三重特異性抗体及びその使用 | |
| WO2018137609A1 (zh) | 抗体偶联物、相关的药物组合物及应用 | |
| JP7127859B2 (ja) | キメラタンパク質を用いたアレルギー疾患の治療 | |
| CN115551539A (zh) | 自身免疫性病症中的抗bcma疗法 | |
| US9546219B2 (en) | Treatment of allergic diseases with recombinant antibodies | |
| AU2019284320B2 (en) | APJ antibody, fusion protein thereof with Elabela, and pharmaceutical compositions and use thereof | |
| TWI906199B (zh) | 製備最佳化之多聚化斯塔都聚體(stradomer) gl-2045 | |
| WO2025076131A1 (en) | Compostions of multispecific antigen binding polypeptides and methods of use | |
| CN117120472A (zh) | 抗cd19抗体及car-t结构 | |
| NZ791361B2 (en) | Engineered anti-il-2 antibodies |