JP2019527543A5 - - Google Patents
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- Publication number
- JP2019527543A5 JP2019527543A5 JP2018567611A JP2018567611A JP2019527543A5 JP 2019527543 A5 JP2019527543 A5 JP 2019527543A5 JP 2018567611 A JP2018567611 A JP 2018567611A JP 2018567611 A JP2018567611 A JP 2018567611A JP 2019527543 A5 JP2019527543 A5 JP 2019527543A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- human
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims description 40
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 12
- 102000048362 human PDCD1 Human genes 0.000 claims description 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 5
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 5
- 238000004220 aggregation Methods 0.000 claims description 5
- 230000002776 aggregation Effects 0.000 claims description 5
- 238000010494 dissociation reaction Methods 0.000 claims description 4
- 230000005593 dissociations Effects 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 3
- 230000000771 oncological effect Effects 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 2
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 239000003981 vehicle Substances 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 230000016615 flocculation Effects 0.000 claims 1
- 238000005189 flocculation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2016128487 | 2016-07-13 | ||
| RU2016128487A RU2656181C1 (ru) | 2016-07-13 | 2016-07-13 | Анти-pd-1-антитела, способ их получения и способ применения |
| PCT/RU2017/050056 WO2018013017A1 (ru) | 2016-07-13 | 2017-07-04 | Анти-pd-1-антитела, способ их получения и способ применения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527543A JP2019527543A (ja) | 2019-10-03 |
| JP2019527543A5 true JP2019527543A5 (enExample) | 2020-08-13 |
| JP6993992B2 JP6993992B2 (ja) | 2022-01-14 |
Family
ID=60953256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567611A Active JP6993992B2 (ja) | 2016-07-13 | 2017-07-04 | 抗ｐｄ－１抗体、その産生方法及びその使用方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11136408B2 (enExample) |
| EP (1) | EP3486257A4 (enExample) |
| JP (1) | JP6993992B2 (enExample) |
| KR (1) | KR102482710B1 (enExample) |
| CN (1) | CN110023335B (enExample) |
| BR (1) | BR112019000436A2 (enExample) |
| CA (1) | CA3021372A1 (enExample) |
| CL (1) | CL2018003407A1 (enExample) |
| CO (1) | CO2019001246A2 (enExample) |
| CR (1) | CR20190009A (enExample) |
| EC (1) | ECSP19010852A (enExample) |
| JO (1) | JOP20190002A1 (enExample) |
| MA (1) | MA44547B1 (enExample) |
| MX (1) | MX2018014937A (enExample) |
| NI (1) | NI201900002A (enExample) |
| NZ (1) | NZ750221A (enExample) |
| PE (1) | PE20190450A1 (enExample) |
| PH (1) | PH12018550179A1 (enExample) |
| RU (1) | RU2656181C1 (enExample) |
| WO (1) | WO2018013017A1 (enExample) |
| ZA (1) | ZA201900792B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL300122A (en) | 2015-11-18 | 2023-03-01 | Merck Sharp ַ& Dohme Llc | Substances that bind to PD1 and/or LAG3 |
| JP7275030B2 (ja) | 2017-01-20 | 2023-05-17 | タユー ファシャ バイオテック メディカル グループ カンパニー， リミテッド | 抗ｐｄ－１抗体およびその使用 |
| BR112019021520A2 (pt) | 2017-04-14 | 2020-08-04 | Tollnine, Inc. | oligonucleotídeo, composto, polinucleotídeo imunomodulador, composição, conjugado, método para modular um receptor, método de tratamento de um tumor, método de tratamento de câncer, método para tratar um tumor, método de prevenção de câncer, método para induzir uma resposta imune |
| US10995149B2 (en) | 2017-06-05 | 2021-05-04 | Janssen Biotech, Inc. | Antibodies that specifically bind PD-1 and methods of use |
| CN118126157A (zh) | 2017-08-03 | 2024-06-04 | 美国安进公司 | 白介素-21突变蛋白和治疗方法 |
| MX2020007291A (es) | 2018-01-12 | 2020-09-10 | Amgen Inc | Anticuerpos anti-pd-1 y metodos de tratamiento. |
| WO2019148410A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1 antibodies |
| EP3823991A4 (en) * | 2018-07-19 | 2022-08-03 | Tayu Huaxia Biotech Medical Group Co., Ltd. | ANTI-PD-1 ANTIBODIES, DOSAGE FORMS AND USES THEREOF |
| CN109652453B (zh) * | 2018-12-29 | 2021-04-06 | 杭州科兴生物科技有限公司 | 一种基于pd-1/pdl-1阻断功能及生物效应的抗癌药物快速筛选方法 |
| US20220241412A1 (en) | 2019-05-24 | 2022-08-04 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| JP7680967B2 (ja) * | 2019-06-14 | 2025-05-21 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｐｄ－１に対する抗体およびその使用方法 |
| TWI844666B (zh) | 2019-08-22 | 2024-06-11 | 俄羅斯聯邦商拜奧卡德聯合股份公司 | 抗ＰＤ－１抗體Ｐｒｏｌｇｏｌｉｍａｂ的水性藥物組合物及其用途 |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| IL295759A (en) | 2020-02-28 | 2022-10-01 | Tallac Therapeutics Inc | Transglutaminase mediated coupling |
| CA3181776A1 (en) | 2020-05-26 | 2021-12-02 | Boehringer Ingelheim International Gmbh | Anti-pd-1 antibodies |
| US20220168293A1 (en) | 2020-12-02 | 2022-06-02 | Pfizer Inc. | Time to resolution of axitinib-related adverse events |
| US20250270320A1 (en) * | 2020-12-10 | 2025-08-28 | Eutilex Co., Ltd. | Anti-pd-1 antibody and uses thereof |
| PE20241732A1 (es) | 2021-03-31 | 2024-08-19 | Merus Nv | Dominios de union a pd-1 novedosos |
| MA62924A1 (fr) | 2021-04-08 | 2024-03-29 | Biocad Joint Stock Co | Traitement de néoplasies malignes à l'aide d'une combinaison d'anticorps anti-pd-1 |
| TW202327595A (zh) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | 用於治療癌症之氮雜內醯胺化合物的組合 |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| CN116925223A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗pd-1单克隆抗体及其衍生物和用途 |
| EP4598960A1 (en) * | 2022-10-05 | 2025-08-13 | Chulalongkorn University | Monoclonal antibodies against human programmed cell death protein 1 (pd-1) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3530736A3 (en) * | 2005-05-09 | 2019-11-06 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| PT2170959E (pt) * | 2007-06-18 | 2014-01-07 | Merck Sharp & Dohme | Anticorpos para o receptor humano de morte programada pd-1 |
| US8062852B2 (en) * | 2007-10-01 | 2011-11-22 | The Children's Hospital And Regional Medical Center | Detection and treatment of autoimmune disorders |
| EP3279215B1 (en) * | 2009-11-24 | 2020-02-12 | MedImmune Limited | Targeted binding agents against b7-h1 |
| CN102892786B (zh) * | 2010-03-11 | 2016-03-16 | Ucb医药有限公司 | Pd-1抗体 |
| TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| LT2691417T (lt) * | 2011-03-29 | 2018-10-25 | Roche Glycart Ag | Antikūno fc variantai |
| RS61400B1 (sr) * | 2013-05-02 | 2021-02-26 | Anaptysbio Inc | Antitela usmerena protiv programirane smrti-1 (pd-1) |
| SMT202300039T1 (it) * | 2013-09-13 | 2023-03-17 | Beigene Switzerland Gmbh | Anticorpi anti-pd1 e loro uso come terapia e per diagnostica |
| EP3177640B1 (en) * | 2014-08-08 | 2020-05-06 | The Board of Trustees of the Leland Stanford Junior University | High affinity pd-1 agents and methods of use |
| GB201419084D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-PD-1 antibodies |
| TWI595006B (zh) * | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
-
2016
- 2016-07-13 RU RU2016128487A patent/RU2656181C1/ru active
-
2017
- 2017-06-16 JO JOP/2019/0002A patent/JOP20190002A1/ar unknown
- 2017-07-04 CA CA3021372A patent/CA3021372A1/en active Pending
- 2017-07-04 NZ NZ750221A patent/NZ750221A/en unknown
- 2017-07-04 MA MA44547A patent/MA44547B1/fr unknown
- 2017-07-04 BR BR112019000436A patent/BR112019000436A2/pt unknown
- 2017-07-04 PE PE2019000027A patent/PE20190450A1/es unknown
- 2017-07-04 EP EP17828049.1A patent/EP3486257A4/en active Pending
- 2017-07-04 US US16/095,800 patent/US11136408B2/en active Active
- 2017-07-04 MX MX2018014937A patent/MX2018014937A/es unknown
- 2017-07-04 CR CR20190009A patent/CR20190009A/es unknown
- 2017-07-04 CN CN201780055794.3A patent/CN110023335B/zh active Active
- 2017-07-04 WO PCT/RU2017/050056 patent/WO2018013017A1/ru not_active Ceased
- 2017-07-04 KR KR1020197003862A patent/KR102482710B1/ko active Active
- 2017-07-04 JP JP2018567611A patent/JP6993992B2/ja active Active
-
2018
- 2018-10-26 PH PH12018550179A patent/PH12018550179A1/en unknown
- 2018-11-29 CL CL2018003407A patent/CL2018003407A1/es unknown
-
2019
- 2019-01-08 NI NI201900002A patent/NI201900002A/es unknown
- 2019-02-07 ZA ZA2019/00792A patent/ZA201900792B/en unknown
- 2019-02-12 CO CONC2019/0001246A patent/CO2019001246A2/es unknown
- 2019-02-13 EC ECSENADI201910852A patent/ECSP19010852A/es unknown
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