MX2019014577A - Anticuerpos que se unen especificamente a pd-1 y metodos de uso. - Google Patents
Anticuerpos que se unen especificamente a pd-1 y metodos de uso.Info
- Publication number
- MX2019014577A MX2019014577A MX2019014577A MX2019014577A MX2019014577A MX 2019014577 A MX2019014577 A MX 2019014577A MX 2019014577 A MX2019014577 A MX 2019014577A MX 2019014577 A MX2019014577 A MX 2019014577A MX 2019014577 A MX2019014577 A MX 2019014577A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- methods
- specifically bind
- fragments
- inflammatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Los anticuerpos que se unen específicamente a PD-1 o fragmentos de unión al antígeno de estos, los polinucleótidos que codifican los anticuerpos o fragmentos, y los métodos de fabricación y uso de los anteriores son útiles en el tratamiento de trastornos inflamatorios o inmunitarios.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762515188P | 2017-06-05 | 2017-06-05 | |
US201862648114P | 2018-03-26 | 2018-03-26 | |
US201862673185P | 2018-05-18 | 2018-05-18 | |
PCT/US2018/035843 WO2018226580A2 (en) | 2017-06-05 | 2018-06-04 | Antibodies that specifically bind pd-1 and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019014577A true MX2019014577A (es) | 2020-07-29 |
Family
ID=64562613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019014577A MX2019014577A (es) | 2017-06-05 | 2018-06-04 | Anticuerpos que se unen especificamente a pd-1 y metodos de uso. |
Country Status (23)
Country | Link |
---|---|
US (3) | US10995149B2 (es) |
EP (1) | EP3634995A4 (es) |
JP (1) | JP7235733B2 (es) |
KR (1) | KR20200014414A (es) |
CN (1) | CN110997712B (es) |
AU (1) | AU2018282094A1 (es) |
BR (1) | BR112019025574A2 (es) |
CA (1) | CA3065516A1 (es) |
CL (1) | CL2019003520A1 (es) |
CO (1) | CO2019013935A2 (es) |
CR (1) | CR20190550A (es) |
EC (1) | ECSP19086810A (es) |
IL (1) | IL271009A (es) |
MA (1) | MA52459A (es) |
MX (1) | MX2019014577A (es) |
NI (1) | NI201900123A (es) |
PE (1) | PE20200294A1 (es) |
PH (1) | PH12019502755A1 (es) |
TW (1) | TWI806873B (es) |
UA (1) | UA128035C2 (es) |
UY (1) | UY37761A (es) |
WO (1) | WO2018226580A2 (es) |
ZA (1) | ZA202000051B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3065125A1 (en) * | 2017-06-02 | 2018-12-06 | Bayer Aktiengesellschaft | Combination of regorafenib and pd-1/pd-l1(2) inhibitors for treating cancer |
AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
US20220298211A1 (en) * | 2019-06-04 | 2022-09-22 | Qiang Chen | PLANT-PRODUCED mABs AGAINST CHIKUNGUNYA VIRUS WITH ENHANCED EFFECTOR FUNCTION AND EFFICACY |
KR20220030956A (ko) | 2019-07-05 | 2022-03-11 | 오노 야꾸힝 고교 가부시키가이샤 | Pd-1/cd3 이중 특이성 단백질에 의한 혈액암 치료 |
JP6856183B1 (ja) * | 2019-07-30 | 2021-04-07 | 小野薬品工業株式会社 | 二重特異性抗体 |
WO2021025140A1 (ja) | 2019-08-08 | 2021-02-11 | 小野薬品工業株式会社 | 二重特異性タンパク質 |
CN115956087A (zh) | 2020-05-26 | 2023-04-11 | 勃林格殷格翰国际有限公司 | 抗-pd-1抗体 |
WO2022156773A1 (en) * | 2021-01-21 | 2022-07-28 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd | Protein complexes targeting il12 pathway |
AU2022272835A1 (en) | 2021-05-13 | 2023-11-02 | Foundation For Biomedical Research And Innovation At Kobe | Anti-human pd-1 agonist antibody and pharmaceutical composition comprising the antibody for treating or preventing inflammatory diseases |
AU2022294106A1 (en) * | 2021-06-18 | 2024-01-25 | Therini Bio, Inc. | ANTIBODIES WHICH BIND HUMAN FIBRIN OR FIBRINOGEN γC DOMAIN AND METHODS OF USE |
WO2023089377A2 (en) | 2021-11-19 | 2023-05-25 | Mirobio Limited | Engineered pd-1 antibodies and uses thereof |
WO2024010861A2 (en) * | 2022-07-06 | 2024-01-11 | Santa Ana Bio, Inc. | Methods and compositions for treating autoimmune, allergic and inflammatory diseases |
CN116854820B (zh) * | 2023-06-26 | 2024-02-06 | 华中科技大学同济医学院附属协和医院 | Pd-1非阻断性清除抗体及其用途 |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
ES2206447T3 (es) | 1991-06-14 | 2004-05-16 | Genentech, Inc. | Anticuerpo humanizado para heregulina. |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
EP1724282B1 (en) | 1997-05-21 | 2013-05-15 | Merck Patent GmbH | Method for the production of non-immunogenic proteins |
US6818749B1 (en) | 1998-10-31 | 2004-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Variants of humanized anti carcinoma monoclonal antibody cc49 |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
JP3523245B1 (ja) | 2000-11-30 | 2004-04-26 | メダレックス,インコーポレーテッド | ヒト抗体作製用トランスジェニック染色体導入齧歯動物 |
AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー/エス | 二重特異性抗体の生産 |
US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
JP2010535032A (ja) | 2007-07-31 | 2010-11-18 | メディミューン,エルエルシー | 多重特異性エピトープ結合性タンパク質およびその用途 |
US8748356B2 (en) | 2007-10-19 | 2014-06-10 | Janssen Biotech, Inc. | Methods for use in human-adapting monoclonal antibodies |
CN101970730A (zh) | 2007-12-19 | 2011-02-09 | 森托科尔奥索生物科技公司 | 通过融合到pⅨ或pⅦ来设计和生成人从头pⅨ噬菌体展示文库,载体、抗体及方法 |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
WO2010029434A1 (en) | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
AU2009290544B2 (en) | 2008-09-12 | 2015-07-16 | Oxford University Innovation Limited | PD-1 specific antibodies and uses thereof |
EP2347038A4 (en) | 2008-10-14 | 2013-06-12 | Janssen Biotech Inc | METHOD FOR HUMANIZATION AND AFFINITY TREATMENT OF ANTIBODIES |
CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
JP5920929B2 (ja) | 2010-03-11 | 2016-05-18 | ユセベ ファルマ ソシエテ アノニム | Pd−1抗体 |
TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
US9150663B2 (en) | 2010-04-20 | 2015-10-06 | Genmab A/S | Heterodimeric antibody Fc-containing proteins and methods for production thereof |
AU2011325833C1 (en) | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
EP2643351A1 (en) | 2010-11-24 | 2013-10-02 | Glaxo Group Limited | Multispecific antigen binding proteins targeting hgf |
WO2013063702A1 (en) | 2011-11-04 | 2013-05-10 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
LT2970980T (lt) | 2013-03-15 | 2018-10-25 | Janssen Biotech, Inc. | Gamybos būdas kontroliuoti c galinio lizino, galaktozės ir sialo rūgšties kiekį rekombinantiniuose baltymuose |
CN104558177B (zh) | 2013-10-25 | 2020-02-18 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
RS59480B1 (sr) | 2013-12-12 | 2019-12-31 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antitelo, njegov fragment koji se vezuje na antigen, i njegova medicinska primena |
CA2932476A1 (en) | 2013-12-12 | 2015-06-18 | Stemcentrx, Inc. | Novel anti-dpep3 antibodies and methods of use |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
CN106232626B (zh) * | 2014-03-27 | 2022-05-03 | 鸟石生物公司 | 结合人大麻素1(cb1)受体的抗体 |
PT3177644T (pt) * | 2014-08-05 | 2021-01-13 | MabQuest SA | Reagentes imunológicos que se ligam a pd-1 |
TWI595006B (zh) * | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
US10239942B2 (en) | 2014-12-22 | 2019-03-26 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
KR20180034588A (ko) | 2015-07-30 | 2018-04-04 | 마크로제닉스, 인크. | Pd-1-결합 분자 및 그것의 사용 방법 |
CA2993276A1 (en) | 2015-08-11 | 2017-02-16 | Yong Zheng | Novel anti-pd-1 antibodies |
EA201890630A1 (ru) | 2015-09-01 | 2018-10-31 | Эйдженус Инк. | Антитела против pd-1 и способы их применения |
EA201890790A1 (ru) * | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | Связывающие pd-1 белки и способы их применения |
BR112018008904A2 (pt) | 2015-11-03 | 2018-11-27 | Janssen Biotech Inc | anticorpos que se ligam especificamente a tim-3 e seus usos |
RU2656181C1 (ru) | 2016-07-13 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Анти-pd-1-антитела, способ их получения и способ применения |
HUE051700T2 (hu) | 2016-09-14 | 2021-03-29 | Abbvie Biotherapeutics Inc | Anti-PD-1 antitestek |
WO2018053405A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating immune disorders using pd-1 binding proteins |
US11225523B2 (en) | 2017-06-01 | 2022-01-18 | Compugen Ltd. | Triple combination antibody therapies |
EP3679070A1 (en) | 2017-09-07 | 2020-07-15 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
-
2018
- 2018-06-04 EP EP18813493.6A patent/EP3634995A4/en active Pending
- 2018-06-04 JP JP2020516792A patent/JP7235733B2/ja active Active
- 2018-06-04 CR CR20190550A patent/CR20190550A/es unknown
- 2018-06-04 US US15/997,148 patent/US10995149B2/en active Active
- 2018-06-04 CN CN201880050979.XA patent/CN110997712B/zh active Active
- 2018-06-04 UA UAA201912296A patent/UA128035C2/uk unknown
- 2018-06-04 AU AU2018282094A patent/AU2018282094A1/en active Pending
- 2018-06-04 WO PCT/US2018/035843 patent/WO2018226580A2/en active Application Filing
- 2018-06-04 KR KR1020207000242A patent/KR20200014414A/ko not_active Application Discontinuation
- 2018-06-04 CA CA3065516A patent/CA3065516A1/en active Pending
- 2018-06-04 PE PE2019002510A patent/PE20200294A1/es unknown
- 2018-06-04 BR BR112019025574-5A patent/BR112019025574A2/pt unknown
- 2018-06-04 MX MX2019014577A patent/MX2019014577A/es unknown
- 2018-06-04 MA MA052459A patent/MA52459A/fr unknown
- 2018-06-05 UY UY0001037761A patent/UY37761A/es unknown
- 2018-06-05 TW TW107119358A patent/TWI806873B/zh active
-
2019
- 2019-11-28 IL IL271009A patent/IL271009A/en unknown
- 2019-12-02 CL CL2019003520A patent/CL2019003520A1/es unknown
- 2019-12-04 NI NI201900123A patent/NI201900123A/es unknown
- 2019-12-05 PH PH12019502755A patent/PH12019502755A1/en unknown
- 2019-12-05 EC ECSENADI201986810A patent/ECSP19086810A/es unknown
- 2019-12-11 CO CONC2019/0013935A patent/CO2019013935A2/es unknown
-
2020
- 2020-01-03 ZA ZA2020/00051A patent/ZA202000051B/en unknown
- 2020-12-17 US US17/125,263 patent/US11746161B2/en active Active
-
2023
- 2023-06-08 US US18/331,280 patent/US20230340155A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US10995149B2 (en) | 2021-05-04 |
CN110997712B (zh) | 2024-03-19 |
CO2019013935A2 (es) | 2020-01-17 |
JP7235733B2 (ja) | 2023-03-08 |
EP3634995A4 (en) | 2021-06-09 |
EP3634995A2 (en) | 2020-04-15 |
KR20200014414A (ko) | 2020-02-10 |
ECSP19086810A (es) | 2020-02-28 |
MA52459A (fr) | 2021-03-10 |
CR20190550A (es) | 2020-04-05 |
US20230340155A1 (en) | 2023-10-26 |
TWI806873B (zh) | 2023-07-01 |
WO2018226580A3 (en) | 2019-01-31 |
PH12019502755A1 (en) | 2020-06-08 |
CL2019003520A1 (es) | 2020-05-08 |
WO2018226580A2 (en) | 2018-12-13 |
PE20200294A1 (es) | 2020-02-05 |
UY37761A (es) | 2019-01-02 |
JP2020522278A (ja) | 2020-07-30 |
ZA202000051B (en) | 2021-07-28 |
TW201906863A (zh) | 2019-02-16 |
US20180355061A1 (en) | 2018-12-13 |
UA128035C2 (uk) | 2024-03-20 |
BR112019025574A2 (pt) | 2020-06-23 |
IL271009A (en) | 2020-01-30 |
US11746161B2 (en) | 2023-09-05 |
US20210102000A1 (en) | 2021-04-08 |
NI201900123A (es) | 2020-12-01 |
AU2018282094A1 (en) | 2019-12-12 |
CA3065516A1 (en) | 2018-12-13 |
CN110997712A (zh) | 2020-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12019502755A1 (en) | Antibodies that specifically bind pd-1 and methods of use | |
MX2018005550A (es) | Anticuerpos que se unen especificamente a tim-3 y sus usos. | |
PH12018502225A1 (en) | Anti-il-33 antibodies, compositions, methods and uses thereof | |
MX2022003718A (es) | Anticuerpos que se unen a cd39 y sus usos. | |
PH12020551920A1 (en) | Anti-cd3 antibodies and uses thereof | |
MX2020000960A (es) | Anticuerpos anti-tigit. | |
MX2020002694A (es) | Moleculas de anticuerpo que se unen a tim-3 y usos de las mismas. | |
PH12016501644B1 (en) | Binding proteins and methods of use thereof | |
NZ743124A (en) | Antibodies targeting fc receptor-like 5 and methods of use | |
MX2017004311A (es) | Anticuerpos del receptor del factor de necrosis tumoral inducido por glucocorticoide (gitr) y metodos de uso de los mismos. | |
MX2017014955A (es) | Agentes de union a inmunorreceptor de celulas t con dominios ig y motivo de inhibicion basado en tirosina de inmunorreceptor (tigit) y usos de los mismos. | |
MY185813A (en) | Factor xi antibodies and methods of use | |
ZA201807920B (en) | Anti¿gitr antibodies and uses thereof | |
MX2019015516A (es) | Anticuerpos de union a il-1beta para el uso en el tratamiento del cancer. | |
PH12019502087A1 (en) | Anti-par2 antibodies and uses thereof | |
MX2018016183A (es) | Anticuerpos especificos del ligando 1 de muerte programada y metodos de uso de los mismos. | |
MX2019015738A (es) | Regimen de dosificacion para anticuerpos anti-tim-3 y usos de los mismos. | |
MX2017001959A (es) | Anticuerpos especificos para mmp9. | |
MX2021001268A (es) | Anticuerpos anti-btn3a y su uso en el tratamiento del cáncer o trastornos infecciosos. | |
WO2018069871A3 (en) | Anti-kras binding proteins | |
PH12018501739A1 (en) | Antibodies for il-17c | |
MX2017007747A (es) | Anticuerpos para il-17c. | |
MX2019000963A (es) | Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (gitr) y sus metodos de uso. |