|
US459007A
(en)
|
|
1891-09-08 |
|
Porte |
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4169888A
(en)
|
1977-10-17 |
1979-10-02 |
The Upjohn Company |
Composition of matter and process
|
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
US4364935A
(en)
|
1979-12-04 |
1982-12-21 |
Ortho Pharmaceutical Corporation |
Monoclonal antibody to a human prothymocyte antigen and methods of preparing same
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
|
US4970198A
(en)
|
1985-10-17 |
1990-11-13 |
American Cyanamid Company |
Antitumor antibiotics (LL-E33288 complex)
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
JPS63502716A
(ja)
|
1986-03-07 |
1988-10-13 |
マサチューセッツ・インステチュート・オブ・テクノロジー |
糖タンパク安定性の強化方法
|
|
EP0271581B1
(en)
|
1986-04-17 |
1993-01-13 |
Kyowa Hakko Kogyo Co., Ltd. |
Novel compounds dc-88a and dc-89a1 and process for their preparation
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
|
US5053394A
(en)
|
1988-09-21 |
1991-10-01 |
American Cyanamid Company |
Targeted forms of methyltrithio antitumor agents
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
JP3040121B2
(ja)
|
1988-01-12 |
2000-05-08 |
ジェネンテク，インコーポレイテッド |
増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
|
|
FI102355B1
(fi)
|
1988-02-11 |
1998-11-30 |
Bristol Myers Squibb Co |
Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi
|
|
US5084468A
(en)
|
1988-08-11 |
1992-01-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-88a derivatives
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
JP2598116B2
(ja)
|
1988-12-28 |
1997-04-09 |
協和醗酵工業株式会社 |
新規物質ｄｃ１１３
|
|
US5187186A
(en)
|
1989-07-03 |
1993-02-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Pyrroloindole derivatives
|
|
JP2510335B2
(ja)
|
1989-07-03 |
1996-06-26 |
協和醗酵工業株式会社 |
Ｄｃ―８８ａ誘導体
|
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
IE911537A1
(en)
|
1990-05-07 |
1991-11-20 |
Scripps Clinic Res |
Intermediates in the formation of the calicheamicin and¹esperamicin oligosaccharides
|
|
US5968509A
(en)
|
1990-10-05 |
1999-10-19 |
Btp International Limited |
Antibodies with binding affinity for the CD3 antigen
|
|
CZ282603B6
(cs)
|
1991-03-06 |
1997-08-13 |
Merck Patent Gesellschaft Mit Beschränkter Haftun G |
Humanizované a chimerické monoklonální protilátky
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
CA2103059C
(en)
|
1991-06-14 |
2005-03-22 |
Paul J. Carter |
Method for making humanized antibodies
|
|
US5264586A
(en)
|
1991-07-17 |
1993-11-23 |
The Scripps Research Institute |
Analogs of calicheamicin gamma1I, method of making and using the same
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
|
DE69231123T2
(de)
|
1992-03-25 |
2001-02-15 |
Immunogen Inc |
Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
US6329507B1
(en)
|
1992-08-21 |
2001-12-11 |
The Dow Chemical Company |
Dimer and multimer forms of single chain polypeptides
|
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
EP0672142B1
(en)
|
1992-12-04 |
2001-02-28 |
Medical Research Council |
Multivalent and multispecific binding proteins, their manufacture and use
|
|
SG55079A1
(en)
|
1992-12-11 |
1998-12-21 |
Dow Chemical Co |
Multivalent single chain antibodies
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
ES2233928T3
(es)
|
1993-10-01 |
2005-06-16 |
Teikoku Hormone Mfg. Co., Ltd. |
Derivados de dolastatina.
|
|
GB9401182D0
(en)
|
1994-01-21 |
1994-03-16 |
Inst Of Cancer The Research |
Antibodies to EGF receptor and their antitumour effect
|
|
CA2165819C
(en)
|
1994-04-22 |
2005-12-27 |
Nobuyoshi Amishiro |
Dc-89 derivatives
|
|
JPH07309761A
(ja)
|
1994-05-20 |
1995-11-28 |
Kyowa Hakko Kogyo Co Ltd |
デュオカルマイシン誘導体の安定化法
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
US5945311A
(en)
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
|
US5550246A
(en)
|
1994-09-07 |
1996-08-27 |
The Scripps Research Institute |
Calicheamicin mimics
|
|
US5541087A
(en)
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
WO1996040210A1
(en)
|
1995-06-07 |
1996-12-19 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth of tumors
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
US7696338B2
(en)
|
1995-10-30 |
2010-04-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Immunotoxin fusion proteins and means for expression thereof
|
|
DE69626849T2
(de)
|
1995-12-22 |
2003-12-24 |
Bristol-Myers Squibb Co., Princeton |
Verzweigte hydrazongruppen enthaltende kuppler
|
|
WO1997024373A1
(en)
|
1995-12-29 |
1997-07-10 |
Medvet Science Pty. Limited |
Monoclonal antibody antagonists to haemopoietic growth factors
|
|
US5834597A
(en)
|
1996-05-20 |
1998-11-10 |
Protein Design Labs, Inc. |
Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
|
|
AUPN999096A0
(en)
|
1996-05-22 |
1996-06-13 |
Northstar Biologicals Pty Ltd |
Peptides, antibodies, vaccines & uses thereof
|
|
EP0915987A2
(en)
|
1997-04-21 |
1999-05-19 |
Donlar Corporation |
POLY-($g(a)-L-ASPARTIC ACID), POLY-($g(a)-L-GLUTAMIC ACID) AND COPOLYMERS OF L-ASP AND L-GLU, METHOD FOR THEIR PRODUCTION AND THEIR USE
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
DK0979281T3
(da)
|
1997-05-02 |
2005-11-21 |
Genentech Inc |
Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
ES2234241T3
(es)
|
1998-01-23 |
2005-06-16 |
Vlaams Interuniversitair Instituut Voor Biotechnologie |
Derivados de anticuerpo de multiples fines.
|
|
PT1071700E
(pt)
|
1998-04-20 |
2010-04-23 |
Glycart Biotechnology Ag |
Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
|
|
WO1999054440A1
(en)
|
1998-04-21 |
1999-10-28 |
Micromet Gesellschaft Für Biomedizinische Forschung Mbh |
CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF
|
|
US6455677B1
(en)
|
1998-04-30 |
2002-09-24 |
Boehringer Ingelheim International Gmbh |
FAPα-specific antibody with improved producibility
|
|
JP4113670B2
(ja)
*
|
1998-06-22 |
2008-07-09 |
イムノメディクス， インコーポレイテッド |
プレターゲッティング診断およびプレターゲッティング治療のための二重特異性抗体の使用
|
|
GB9815909D0
(en)
|
1998-07-21 |
1998-09-16 |
Btg Int Ltd |
Antibody preparation
|
|
US6723538B2
(en)
|
1999-03-11 |
2004-04-20 |
Micromet Ag |
Bispecific antibody and chemokine receptor constructs
|
|
WO2000061739A1
(fr)
|
1999-04-09 |
2000-10-19 |
Kyowa Hakko Kogyo Co., Ltd. |
Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
|
|
US6939545B2
(en)
|
1999-04-28 |
2005-09-06 |
Genetics Institute, Llc |
Composition and method for treating inflammatory disorders
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
US7303749B1
(en)
|
1999-10-01 |
2007-12-04 |
Immunogen Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
WO2001024763A2
(en)
|
1999-10-01 |
2001-04-12 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
US7504256B1
(en)
|
1999-10-19 |
2009-03-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for producing polypeptide
|
|
US6716410B1
(en)
|
1999-10-26 |
2004-04-06 |
The Regents Of The University Of California |
Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
|
|
EP1266009B1
(en)
|
2000-02-25 |
2008-12-31 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
ANTI-EGFRvIII SCFVS WITH IMPROVED CYTOTOXICITY AND YIELD, IMMUNOTOXINS BASED THEREON, AND METHODS OF USE THEREOF
|
|
US7449443B2
(en)
|
2000-03-23 |
2008-11-11 |
California Institute Of Technology |
Method for stabilization of proteins using non-natural amino acids
|
|
US20010035606A1
(en)
|
2000-03-28 |
2001-11-01 |
Schoen Alan H. |
Set of blocks for packing a cube
|
|
MXPA02010787A
(es)
|
2000-05-03 |
2003-07-14 |
Amgen Inc |
Peptidos modificados como agentes terapeuticos.
|
|
ES2259030T3
(es)
|
2000-05-19 |
2006-09-16 |
Scancell Limited |
Anticuerpos humanizados frente al receptor del factor de crecimiento epidermico.
|
|
EP1299419A2
(en)
|
2000-05-24 |
2003-04-09 |
Imclone Systems, Inc. |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
US6586207B2
(en)
|
2000-05-26 |
2003-07-01 |
California Institute Of Technology |
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
|
|
CA2417185A1
(en)
|
2000-07-25 |
2002-01-31 |
Shui-On Leung |
Multivalent target binding protein
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
DE10043437A1
(de)
|
2000-09-04 |
2002-03-28 |
Horst Lindhofer |
Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites
|
|
MXPA03002974A
(es)
|
2000-10-06 |
2004-05-05 |
Kyowa Hakko Kogyo Kk |
Celulas que producen composiciones de anticuerpo.
|
|
EP1333032A4
(en)
|
2000-10-06 |
2005-03-16 |
Kyowa Hakko Kogyo Kk |
PROCESS FOR PURIFYING ANTIBODY
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US20020147312A1
(en)
|
2001-02-02 |
2002-10-10 |
O'keefe Theresa |
Hybrid antibodies and uses thereof
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
AU2002307037B2
(en)
|
2001-04-02 |
2008-08-07 |
Biogen Idec Inc. |
Recombinant antibodies coexpressed with GnTIII
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
KR20030033007A
(ko)
|
2001-05-31 |
2003-04-26 |
코울터 파머수티컬, 인코포레이티드 |
세포독소, 약물전구체, 링커 및 이에 유용한 안정화제
|
|
RU2335507C2
(ru)
|
2001-06-13 |
2008-10-10 |
Генмаб А/С |
Человеческие моноклональные антитела к рецептору эпидермального фактора роста (egfr), способ их получения и их использование, гибридома, трансфектома, трансгенное животное, экспрессионный вектор
|
|
JP2003111595A
(ja)
*
|
2001-06-25 |
2003-04-15 |
Kyogo Ito |
腫瘍抗原
|
|
US20040242851A1
(en)
|
2001-06-26 |
2004-12-02 |
Zhenping Zhu |
Bispecific antibodies that bind to vegf receptors
|
|
US6513428B1
(en)
|
2001-07-23 |
2003-02-04 |
Heidelberger Druckmaschinen Ag |
Device and method for attaching a printing web to a webbing sail and device and method for webbing-up a printing machine
|
|
NZ532526A
(en)
|
2001-10-25 |
2007-01-26 |
Genentech Inc |
Compositions comprising a glycoprotein having a Fc region
|
|
KR101033196B1
(ko)
*
|
2002-02-14 |
2011-05-09 |
이뮤노메딕스, 인코오포레이티드 |
항-ｃｄ20 항체 및 그 융합 단백질 및 이들의 이용방법
|
|
EP1490677A4
(en)
|
2002-02-27 |
2006-01-18 |
California Inst Of Techn |
COMPUTER METHOD FOR DESIGNING ENZYMES FOR THE INCORPORATION OF AMINO ACID ANALOGUES INTO PROTEINS
|
|
US7657380B2
(en)
|
2003-12-04 |
2010-02-02 |
Xencor, Inc. |
Methods of generating variant antibodies with increased host string content
|
|
US20080219974A1
(en)
|
2002-03-01 |
2008-09-11 |
Bernett Matthew J |
Optimized antibodies that target hm1.24
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
US7332580B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The University Of California |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
EP2316921B1
(en)
|
2002-05-24 |
2014-05-14 |
Merck Sharp & Dohme Corp. |
Neutralizing human anti-IGFR antibody
|
|
JP4741838B2
(ja)
|
2002-07-31 |
2011-08-10 |
シアトル ジェネティクス，インコーポレーテッド |
癌、自己免疫疾患または感染症を治療するための薬物結合体およびその使用
|
|
US8946387B2
(en)
|
2002-08-14 |
2015-02-03 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
US7820166B2
(en)
|
2002-10-11 |
2010-10-26 |
Micromet Ag |
Potent T cell modulating molecules
|
|
JP2006507322A
(ja)
|
2002-11-14 |
2006-03-02 |
シンタルガ・ビーブイ |
多重自己脱離放出スペーサーとして構築されたプロドラッグ
|
|
NZ540555A
(en)
|
2002-11-15 |
2008-04-30 |
Genmab As |
Antibody therapeutics for treatingand/or preventing diseases associated with cells expressing CD25, including autoimmune diseases, inflammatory and hyperproliferative skin disorders
|
|
BR0316880A
(pt)
|
2002-12-23 |
2005-10-25 |
Wyeth Corp |
Anticorpos contra pd-1 e usos dos mesmos
|
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
EP3524611B1
(en)
|
2003-05-20 |
2020-12-30 |
ImmunoGen, Inc. |
Improved cytotoxic agents comprising new maytansinoids
|
|
RU2005141512A
(ru)
|
2003-05-31 |
2007-07-20 |
Микромет Аг (De) |
Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками
|
|
AU2004242847B2
(en)
|
2003-05-31 |
2011-06-09 |
Amgen Research (Munich) Gmbh |
Pharmaceutical composition comprising a bispecific antibody for EpCAM
|
|
US7888134B2
(en)
|
2003-06-05 |
2011-02-15 |
Oakland University |
Immunosensors: scFv-linker design for surface immobilization
|
|
CA2531118C
(en)
|
2003-07-01 |
2013-01-08 |
Immunomedics, Inc. |
Multivalent carriers of bi-specific antibodies
|
|
US20150071948A1
(en)
|
2003-09-26 |
2015-03-12 |
Gregory Alan Lazar |
Novel immunoglobulin variants
|
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
|
ES2737837T3
(es)
|
2003-10-09 |
2020-01-16 |
Ambrx Inc |
Derivados poliméricos
|
|
US20050176028A1
(en)
|
2003-10-16 |
2005-08-11 |
Robert Hofmeister |
Deimmunized binding molecules to CD3
|
|
CN104998273A
(zh)
|
2003-11-06 |
2015-10-28 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
EP1701979A2
(en)
|
2003-12-03 |
2006-09-20 |
Xencor, Inc. |
Optimized antibodies that target the epidermal growth factor receptor
|
|
EP2275448A3
(en)
|
2003-12-19 |
2013-02-06 |
Genentech, Inc. |
Monovalent antibody fragments useful as therapeutics
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
NZ548255A
(en)
|
2004-02-02 |
2010-10-29 |
Ambrx Inc |
Modified human interferon polypeptides and their uses
|
|
JP2008504013A
(ja)
|
2004-02-06 |
2008-02-14 |
モルフォシス・アクチェンゲゼルシャフト |
抗ｃｄ３８ヒト抗体及びその用途
|
|
EP2053062A1
(en)
|
2004-03-24 |
2009-04-29 |
Xencor, Inc. |
Immunoglobin variants outside the Fc region
|
|
AU2005244751A1
(en)
*
|
2004-04-16 |
2005-12-01 |
Genentech, Inc. |
Method for augmenting B cell depletion
|
|
US7850962B2
(en)
|
2004-04-20 |
2010-12-14 |
Genmab A/S |
Human monoclonal antibodies against CD20
|
|
WO2005112919A2
(en)
|
2004-05-19 |
2005-12-01 |
Medarex, Inc. |
Self-immolative linkers and drug conjugates
|
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
|
WO2005118635A2
(en)
|
2004-06-03 |
2005-12-15 |
Novimmune S.A. |
Anti-cd3 antibodies and methods of use thereof
|
|
WO2006004910A2
(en)
|
2004-06-28 |
2006-01-12 |
Transtarget Inc. |
Improved bispecific antibodies
|
|
PT1674111E
(pt)
|
2004-07-09 |
2010-12-15 |
Chugai Pharmaceutical Co Ltd |
Anticorpo anti-glipicano 3
|
|
WO2006020258A2
(en)
|
2004-07-17 |
2006-02-23 |
Imclone Systems Incorporated |
Novel tetravalent bispecific antibody
|
|
ZA200701783B
(en)
|
2004-09-02 |
2009-10-28 |
Genentech Inc |
Anti-Fc-gamma RIIB receptor antibody and uses therefor
|
|
EP3088004B1
(en)
|
2004-09-23 |
2018-03-28 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
DK1797127T3
(en)
|
2004-09-24 |
2017-10-02 |
Amgen Inc |
Modified Fc molecules
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8546543B2
(en)
|
2004-11-12 |
2013-10-01 |
Xencor, Inc. |
Fc variants that extend antibody half-life
|
|
US8066989B2
(en)
|
2004-11-30 |
2011-11-29 |
Trion Pharma Gmbh |
Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
|
|
ATE414718T1
(de)
|
2005-01-05 |
2008-12-15 |
F Star Biotech Forsch & Entw |
Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften
|
|
US8716451B2
(en)
|
2005-01-12 |
2014-05-06 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human IgG2 and IgG3 antibodies
|
|
CN101198698B
(zh)
|
2005-03-31 |
2014-03-19 |
中外制药株式会社 |
通过调节多肽缔合制备多肽的方法
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
US9284375B2
(en)
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
CA2607305A1
(en)
|
2005-05-12 |
2006-11-23 |
The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services |
Anti-mesothelin antibodies useful for immunological assays
|
|
RS52861B
(sr)
|
2005-06-07 |
2013-12-31 |
Esbatech - A Novartis Company Llc |
Stabilna i rastvorljiva antitela koja inhibiraju tnf (alfa)
|
|
EP1899477A4
(en)
|
2005-07-01 |
2010-01-20 |
Medimmune Inc |
INTEGRATED APPROACH FOR GENERATING MULTIDOMAIN PROTEIN THERAPEUTIC APPLICATIONS
|
|
US8741566B2
(en)
|
2005-07-01 |
2014-06-03 |
Dako Denmark A/S |
Immunohistochemistry and in situ hybridization detection method
|
|
US20080213273A1
(en)
|
2005-07-25 |
2008-09-04 |
Trubion Pharmaceuticals Inc. |
Single dose use of CD20-specific binding molecules
|
|
PT1912675E
(pt)
|
2005-07-25 |
2014-05-09 |
Emergent Product Dev Seattle |
Moléculas de ligaçao especificas para cd37 e especificas para cd20
|
|
CA2617907A1
(en)
|
2005-08-05 |
2007-02-15 |
Syntarga B.V. |
Triazole-containing releasable linkers and conjugates comprising the same
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
WO2007033230A2
(en)
|
2005-09-12 |
2007-03-22 |
Novimmune S.A. |
Anti-cd3 antibody formulations
|
|
EP1931709B1
(en)
|
2005-10-03 |
2016-12-07 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
|
EP3770174A1
(en)
|
2005-10-11 |
2021-01-27 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
|
HUE035250T2
(hu)
|
2005-10-12 |
2018-05-02 |
Morphosys Ag |
Humán CD38-ra specifikus teljesen humán HuCAL GOLD-eredetû terápiás ellenanyagok létrehozása és profilozása
|
|
CN101331223A
(zh)
|
2005-10-14 |
2008-12-24 |
米迪缪尼有限公司 |
细胞展示抗体文库
|
|
WO2007047829A2
(en)
|
2005-10-19 |
2007-04-26 |
Laboratoires Serono S.A. |
Novel heterodimeric proteins and uses thereof
|
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
|
TW200732350A
(en)
|
2005-10-21 |
2007-09-01 |
Amgen Inc |
Methods for generating monovalent IgG
|
|
CA2627190A1
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
US7820165B2
(en)
|
2005-11-21 |
2010-10-26 |
Merck Serono, S.A. |
Compositions and methods of producing hybrid antigen binding molecules and uses thereof
|
|
KR20080090441A
(ko)
|
2005-12-21 |
2008-10-08 |
메디뮨 엘엘씨 |
Ｅｐｈａ２ ｂｉｔｅ 분자 및 이의 용도
|
|
WO2007084342A2
(en)
|
2006-01-13 |
2007-07-26 |
The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health |
Codon optimi zed il- 15 and il- 15r-alpha genes for expression in mammalian cells
|
|
KR20080114709A
(ko)
|
2006-02-02 |
2008-12-31 |
신타가 비.브이. |
수용성 ｃｃ-1065 유사체 및 그들의 결합체
|
|
EP1820513A1
(en)
|
2006-02-15 |
2007-08-22 |
Trion Pharma Gmbh |
Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
|
|
EP1829895A1
(en)
|
2006-03-03 |
2007-09-05 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
|
|
SG170750A1
(en)
|
2006-03-17 |
2011-05-30 |
Biogen Idec Inc |
Stabilized polypeptide compositions
|
|
ES2395969T3
(es)
|
2006-03-24 |
2013-02-18 |
Merck Patent Gmbh |
Dominios de proteínas heterodiméricas genéticamente modificados
|
|
JP5144499B2
(ja)
|
2006-03-31 |
2013-02-13 |
中外製薬株式会社 |
二重特異性抗体を精製するための抗体改変方法
|
|
EP3056568B1
(en)
|
2006-03-31 |
2021-09-15 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
EP2007423A2
(en)
|
2006-04-05 |
2008-12-31 |
Pfizer Products Incorporated |
Ctla4 antibody combination therapy
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
|
AT503861B1
(de)
|
2006-07-05 |
2008-06-15 |
F Star Biotech Forsch & Entw |
Verfahren zur manipulation von t-zell-rezeptoren
|
|
AT503902B1
(de)
|
2006-07-05 |
2008-06-15 |
F Star Biotech Forsch & Entw |
Verfahren zur manipulation von immunglobulinen
|
|
CN101548034B
(zh)
|
2006-10-02 |
2013-11-13 |
航道生物技术有限责任公司 |
多样性合成肽和多肽文库的设计和构建
|
|
US7795411B2
(en)
|
2006-10-05 |
2010-09-14 |
Fred Hutchinson Cancer Research Center |
Vectors for expressing in vivo biotinylated recombinant proteins
|
|
PL2383289T3
(pl)
|
2006-10-16 |
2015-03-31 |
Salk Inst Biological Studies |
Antagoniści somatostatyny selektywni względem receptora (SSTR2)
|
|
EP1914242A1
(en)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
GB0624500D0
(en)
|
2006-12-07 |
2007-01-17 |
Istituto Superiore Di Sanito |
A novel passive vaccine for candida infections
|
|
US7862825B2
(en)
|
2007-02-21 |
2011-01-04 |
Mladen Vranic |
Method of controlling tight blood glucose by somatostatin receptor antagonists
|
|
CA2680237C
(en)
|
2007-03-27 |
2018-11-06 |
Sea Lane Biotechnologies, Llc |
Constructs and libraries comprising antibody surrogate light chain sequences
|
|
EP1975178A1
(en)
|
2007-03-30 |
2008-10-01 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Transcytotic modular antibody
|
|
WO2008119566A2
(en)
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific bispecific binders
|
|
PT2520590T
(pt)
|
2007-04-03 |
2018-11-14 |
Amgen Res Munich Gmbh |
Domínio de ligação específico de espécies cruzadas
|
|
WO2008124858A2
(en)
|
2007-04-11 |
2008-10-23 |
F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H. |
Targeted receptor
|
|
EP2703011A3
(en)
|
2007-05-07 |
2014-03-26 |
MedImmune, LLC |
Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
|
|
KR20100021601A
(ko)
|
2007-05-14 |
2010-02-25 |
바이오겐 아이덱 엠에이 인코포레이티드 |
단일-쇄 Ｆｃ(ＳｃＦｃ) 부분, 이를 포함하는 결합 폴리펩타이드, 및 이에 관련된 방법
|
|
EP3392273A1
(en)
|
2007-05-30 |
2018-10-24 |
Xencor, Inc. |
Methods and compositions for inhibiting cd32b expressing cells
|
|
CA2688275A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Stable igg4 antibodies
|
|
CA2691322A1
(en)
|
2007-06-12 |
2008-12-24 |
Wyeth |
Anti-cd20 therapeutic compositions and methods
|
|
NZ600758A
(en)
|
2007-06-18 |
2013-09-27 |
Merck Sharp & Dohme |
Antibodies to human programmed death receptor pd-1
|
|
HUE066143T2
(hu)
|
2007-06-26 |
2024-07-28 |
F Star Therapeutics Ltd |
Kötõágensek megjelenítése
|
|
US8680293B2
(en)
|
2007-08-01 |
2014-03-25 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
|
WO2009017823A2
(en)
|
2007-08-01 |
2009-02-05 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health |
A fold-back diabody diphtheria toxin immunotoxin and methods of use
|
|
CA2697922A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
|
EP2033657A1
(de)
|
2007-09-04 |
2009-03-11 |
Trion Pharma Gmbh |
Intraoperative trifunktionale Antikörper-Applikation zur Prophylaxe intraperitonealer Tumorzelldissemination
|
|
MX2010002683A
(es)
|
2007-09-14 |
2010-03-26 |
Amgen Inc |
Poblaciones de anticuerpos homogeneos.
|
|
CN101874042B9
(zh)
|
2007-09-26 |
2019-01-01 |
中外制药株式会社 |
利用cdr的氨基酸取代来改变抗体等电点的方法
|
|
RU2526512C2
(ru)
|
2007-09-26 |
2014-08-20 |
Чугаи Сейяку Кабусики Кайся |
Модифицированная константная область антитела
|
|
CA2700714C
(en)
|
2007-09-26 |
2018-09-11 |
Ucb Pharma S.A. |
Dual specificity antibody fusions
|
|
HRP20150279T1
(hr)
|
2007-12-26 |
2015-05-08 |
Xencor, Inc. |
Fc inaäśice s promijenjenim vezanjem na fcrn
|
|
AU2009204501B2
(en)
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
WO2009106096A1
(en)
|
2008-02-27 |
2009-09-03 |
Fresenius Biotech Gmbh |
Treatment of resistant tumors with trifunctional antibodies
|
|
RS51975B
(sr)
|
2008-04-11 |
2012-02-29 |
Emergent Product Development Seattle Llc. |
Cd37 imunoterapeutski proizvod i njegova kombinacija sa bifunkcionalnim hemoterapeutskim sredstvom
|
|
WO2009129538A2
(en)
|
2008-04-18 |
2009-10-22 |
Xencor, Inc. |
Human equivalent monoclonal antibodies engineered from nonhuman variable regions
|
|
CA2723197C
(en)
|
2008-05-02 |
2017-09-19 |
Seattle Genetics, Inc. |
Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
|
|
BRPI0913406A2
(pt)
|
2008-06-03 |
2018-01-09 |
Abbott Lab |
imunoglobulinas de domínio variável duplo e usos das mesmas
|
|
CN101628940B
(zh)
*
|
2008-07-15 |
2011-11-23 |
中国科学院生物物理研究所 |
一种单克隆抗体及其应用
|
|
CN102137873A
(zh)
|
2008-08-29 |
2011-07-27 |
西福根有限公司 |
抗cd5抗体
|
|
WO2010028796A1
(en)
|
2008-09-10 |
2010-03-18 |
F. Hoffmann-La Roche Ag |
Trispecific hexavalent antibodies
|
|
WO2010029434A1
(en)
|
2008-09-12 |
2010-03-18 |
Isis Innovation Limited |
Pd-1 specific antibodies and uses thereof
|
|
US20170247470A9
(en)
|
2008-09-17 |
2017-08-31 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
EP3190128B1
(en)
|
2008-09-17 |
2018-11-14 |
Xencor, Inc. |
Compositions and methods for treating ige-mediated disorders
|
|
MX2011003133A
(es)
|
2008-09-26 |
2011-04-21 |
Roche Glycart Ag |
Anticuerpos biespecificos anti-egfr/anti-igf-1r.
|
|
EP2352765B1
(en)
|
2008-10-01 |
2018-01-03 |
Amgen Research (Munich) GmbH |
Cross-species-specific single domain bispecific single chain antibody
|
|
BRPI0919840B1
(pt)
|
2008-10-01 |
2023-02-28 |
Amgen Research (Munich) Gmbh |
Molécula de anticorpo de cadeia única biespecífica, seu uso, e composição farmacêutica que a compreende
|
|
DK2356153T3
(en)
|
2008-10-01 |
2016-07-04 |
Amgen Res Munich Gmbh |
Bispecific single CHAIN PSMAXCD3 ANTIBODY THAT ARE SPECIFICALLY TO ALL SPECIES
|
|
CA2738566C
(en)
|
2008-10-01 |
2024-04-30 |
Micromet Ag |
Bispecific single chain antibodies with specificity for high molecular weight target antigens
|
|
NZ603623A
(en)
|
2008-10-10 |
2014-05-30 |
Emergent Product Dev Seattle |
Tcr complex immunotherapeutics
|
|
JP5677970B2
(ja)
|
2008-11-03 |
2015-02-25 |
シンタルガ・ビーブイ |
新規ｃｃ−１０６５類似体およびその複合体
|
|
CA2750533A1
(en)
|
2009-01-23 |
2010-07-29 |
Biogen Idec Ma Inc. |
Stabilized fc polypeptides with reduced effector function and methods of use
|
|
JP5844159B2
(ja)
|
2009-02-09 |
2016-01-13 |
ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ |
Ｐｄ−１抗体およびｐｄ−ｌ１抗体ならびにその使用
|
|
SG174258A1
(en)
|
2009-03-06 |
2011-10-28 |
Genentech Inc |
Antibody formulation
|
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
|
CN102369215B
(zh)
|
2009-04-02 |
2015-01-21 |
罗切格利卡特公司 |
包含全长抗体和单链Fab片段的多特异性抗体
|
|
SG175078A1
(en)
|
2009-04-07 |
2011-11-28 |
Roche Glycart Ag |
Bispecific anti-erbb-1/anti-c-met antibodies
|
|
SI2417156T1
(sl)
|
2009-04-07 |
2015-06-30 |
Roche Glycart Ag |
Trivalentna, bispecifiäśna protitelesa
|
|
CA2757531A1
(en)
|
2009-04-07 |
2010-10-14 |
Roche Glycart Ag |
Bispecific anti-erbb-3/anti-c-met antibodies
|
|
EP2241576A1
(en)
|
2009-04-17 |
2010-10-20 |
Trion Pharma Gmbh |
Use of trifunctional bispecific antibodies for the treatment of tumors associated with CD133+/EpCAM+ cancer stem cells
|
|
CN102448985B
(zh)
|
2009-05-27 |
2015-08-05 |
霍夫曼-拉罗奇有限公司 |
三或四特异性抗体
|
|
BRPI1015916A2
(pt)
|
2009-06-26 |
2015-09-01 |
Sea Lane Biotechnologies Llc |
Molécula de ácido nucleico, vetor de expressão, célula hospedeira, bem como método para expressão de um construto de cadeia leve substituta (slc) ou de um polipeptídeo de slc
|
|
ES2865648T3
(es)
|
2009-06-26 |
2021-10-15 |
Regeneron Pharma |
Anticuerpos biespecíficos fácilmente aislados con formato de inmunoglobulina nativa
|
|
EP2451840B1
(en)
|
2009-07-08 |
2018-12-26 |
Amgen Inc. |
Design of stable and aggregation free antibody fc molecules through ch3 domain interface engineering
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
DE102009045006A1
(de)
|
2009-09-25 |
2011-04-14 |
Technische Universität Dresden |
Anti-CD33 Antikörper und ihre Anwendung zum Immunotargeting bei der Behandlung von CD33-assoziierten Erkrankungen
|
|
SI2493503T2
(sl)
|
2009-10-27 |
2021-04-30 |
Amgen Research (Munich) Gmbh |
Režim odmerjanja za dajanje cd19xcd3 bispecifičnega protitelesa
|
|
JP2013511281A
(ja)
|
2009-11-23 |
2013-04-04 |
アムジェン インコーポレイテッド |
単量体抗体Ｆｃ
|
|
JP2013512251A
(ja)
|
2009-11-24 |
2013-04-11 |
アンプリミューン、インコーポレーテッド |
Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害
|
|
ES2609043T3
(es)
|
2009-11-30 |
2017-04-18 |
Janssen Biotech, Inc. |
Anticuerpos mutantes Fc con funciones de efecto abladas
|
|
ES2777901T3
(es)
|
2009-12-25 |
2020-08-06 |
Chugai Pharmaceutical Co Ltd |
Método de modificación de polipéptidos para purificar multímeros polipeptídicos
|
|
PT2519543T
(pt)
|
2009-12-29 |
2016-10-07 |
Emergent Product Dev Seattle |
Proteínas de ligação de heterodímero e suas utilizações
|
|
US20130129723A1
(en)
|
2009-12-29 |
2013-05-23 |
Emergent Product Development Seattle, Llc |
Heterodimer Binding Proteins and Uses Thereof
|
|
US20110189178A1
(en)
|
2010-02-04 |
2011-08-04 |
Xencor, Inc. |
Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions
|
|
ES2603559T5
(es)
|
2010-02-08 |
2021-02-22 |
Regeneron Pharma |
Cadena ligera común de ratón
|
|
EP2552957A4
(en)
|
2010-03-29 |
2013-11-20 |
Zymeworks Inc |
ANTIBODIES WITH REINFORCED OR SUPPRESSIVE ACTIVE FUNCTION
|
|
TWI653333B
(zh)
|
2010-04-01 |
2019-03-11 |
安進研究（慕尼黑）有限責任公司 |
跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
|
|
US9150663B2
(en)
|
2010-04-20 |
2015-10-06 |
Genmab A/S |
Heterodimeric antibody Fc-containing proteins and methods for production thereof
|
|
KR101860963B1
(ko)
|
2010-04-23 |
2018-05-24 |
제넨테크, 인크. |
이종다량체 단백질의 생산
|
|
WO2011143545A1
(en)
|
2010-05-14 |
2011-11-17 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
|
SI2580243T1
(sl)
|
2010-06-09 |
2020-02-28 |
Genmab A/S |
Protitelesa proti humanemu CD38
|
|
JP2013532153A
(ja)
|
2010-06-18 |
2013-08-15 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド |
慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体
|
|
CN103052649B
(zh)
|
2010-07-29 |
2015-12-16 |
Xencor公司 |
具有修改的等电点的抗体
|
|
CN103154025B
(zh)
|
2010-08-02 |
2015-07-01 |
宏观基因有限公司 |
共价双抗体及其用途
|
|
CN103068846B9
(zh)
*
|
2010-08-24 |
2016-09-28 |
弗·哈夫曼-拉罗切有限公司 |
包含二硫键稳定性Fv片段的双特异性抗体
|
|
WO2012032080A1
(en)
|
2010-09-07 |
2012-03-15 |
F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H |
Stabilised human fc
|
|
AU2011325833C1
(en)
|
2010-11-05 |
2017-07-13 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
SMT201700250T1
(it)
|
2010-11-10 |
2017-07-18 |
Amgen Res Munich Gmbh |
Prevenzione di effetti avversi provocati da domini leganti cd3 specifici
|
|
EP2638072A4
(en)
|
2010-11-12 |
2014-05-07 |
Univ Rockefeller |
FUSION PROTEINS FOR HIV THERAPY
|
|
EP4279513A3
(en)
|
2010-11-30 |
2024-02-28 |
Chugai Seiyaku Kabushiki Kaisha |
Cytotoxicity-inducing therapeutic agent
|
|
CN105440123B
(zh)
|
2011-02-10 |
2020-10-09 |
罗切格利卡特公司 |
突变体白介素-2多肽
|
|
JP6101638B2
(ja)
|
2011-03-03 |
2017-03-22 |
ザイムワークス，インコーポレイテッド |
多価ヘテロマルチマー足場設計及び構築物
|
|
CA2829628A1
(en)
|
2011-03-11 |
2012-09-20 |
Amgen Inc. |
Method of correlated mutational analysis to improve therapeutic antibodies
|
|
JP5972915B2
(ja)
|
2011-03-16 |
2016-08-17 |
アムジエン・インコーポレーテツド |
Ｆｃ変異体
|
|
WO2012123949A1
(en)
|
2011-03-17 |
2012-09-20 |
Ramot At Tel-Aviv University Ltd. |
Bi- and monospecific, asymmetric antibodies and methods of generating the same
|
|
US9683052B2
(en)
|
2011-03-25 |
2017-06-20 |
Glenmark Pharmaceuticals S.A. |
Hetero-dimeric immunoglobulins
|
|
TWI671315B
(zh)
|
2011-03-28 |
2019-09-11 |
法商賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
SI2691417T2
(sl)
|
2011-03-29 |
2025-05-30 |
Roche Glycart Ag |
FC variante protitelesa
|
|
CN103596985B
(zh)
|
2011-04-19 |
2016-06-08 |
美国政府(由卫生和人类服务部的部长所代表) |
对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途
|
|
EP2701741B1
(en)
|
2011-04-28 |
2020-06-10 |
Amgen Research (Munich) GmbH |
Dosage regimen for administering a cd19xcd3 bispecific antibody to patients at risk for potential adverse effects
|
|
EA201892619A1
(ru)
|
2011-04-29 |
2019-04-30 |
Роше Гликарт Аг |
Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
|
|
BR112013029893A2
(pt)
|
2011-05-21 |
2017-05-30 |
Macrogenics Inc |
molécula de ligação a cd3, anticorpo de ligação a cd3, diacorpo de ligação a cd3 e composição farmacêutica
|
|
CN103582650A
(zh)
|
2011-05-25 |
2014-02-12 |
默沙东公司 |
用于制备具有改善性质的含Fc多肽的方法
|
|
WO2013006544A1
(en)
|
2011-07-06 |
2013-01-10 |
Medimmune, Llc |
Methods for making multimeric polypeptides
|
|
WO2013016714A1
(en)
|
2011-07-28 |
2013-01-31 |
Sea Lane Biotechnologies |
Sur-binding proteins against erbb3
|
|
JP6015448B2
(ja)
|
2011-08-04 |
2016-10-26 |
東レ株式会社 |
癌の治療及び／又は予防用医薬組成物
|
|
WO2013022855A1
(en)
|
2011-08-05 |
2013-02-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points and immunofiltering
|
|
JP6244301B2
(ja)
|
2011-08-18 |
2017-12-06 |
アフィニティ バイオサイエンス ピーティーワイ リミテッド |
可溶性ポリペプチド
|
|
NO2748201T3
(OSRAM)
|
2011-08-23 |
2018-05-12 |
|
|
|
EP2748197A2
(en)
|
2011-08-26 |
2014-07-02 |
Merrimack Pharmaceuticals, Inc. |
Tandem fc bispecific antibodies
|
|
WO2013047748A1
(ja)
|
2011-09-30 |
2013-04-04 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
US10851178B2
(en)
*
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
DK2766392T3
(da)
|
2011-10-10 |
2019-10-07 |
Xencor Inc |
Fremgangsmåde til oprensning af antistoffer
|
|
CN109608543A
(zh)
|
2011-10-20 |
2019-04-12 |
艾斯巴技术-诺华有限责任公司 |
稳定的多抗原结合抗体
|
|
EA034989B1
(ru)
|
2011-10-28 |
2020-04-15 |
Тева Фармасьютикал Австралия Пти Лтд |
Полипептидная конструкция для применения при лечении рака, включающая аттенуированный альфа-интерферон
|
|
EP2787078B1
(en)
|
2011-10-31 |
2019-05-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
|
|
WO2013063702A1
(en)
|
2011-11-04 |
2013-05-10 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
EP2776061B1
(en)
*
|
2011-11-07 |
2019-08-14 |
MedImmune, LLC |
Multispecific and multivalent binding proteins and uses thereof
|
|
US20140212425A1
(en)
*
|
2011-12-05 |
2014-07-31 |
Immunomedics, Inc. |
Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
|
|
SI2794658T1
(sl)
|
2011-12-19 |
2017-05-31 |
Synimmune Gmbh |
Bispecifična molekula protitelesa
|
|
US9975956B2
(en)
|
2011-12-22 |
2018-05-22 |
I2 Pharmaceuticals, Inc. |
Surrogate binding proteins which bind DR4 and/or DR5
|
|
KR20220136441A
(ko)
|
2012-02-24 |
2022-10-07 |
추가이 세이야쿠 가부시키가이샤 |
ＦｃγＲＩＩＢ를 매개로 항원의 소실을 촉진하는 항원 결합 분자
|
|
PT2838917T
(pt)
|
2012-04-20 |
2019-09-12 |
Merus Nv |
Métodos e meios para a produção de moléculas similares a ig heterodiméricas
|
|
NZ701821A
(en)
|
2012-04-30 |
2016-06-24 |
Biocon Ltd |
Targeted/immunomodulatory fusion proteins and methods for making same
|
|
ES2924722T3
(es)
*
|
2012-05-18 |
2022-10-10 |
Aptevo Res & Development Llc |
Unión de inmunofusión de scFv biespecífico (BIf) a CD123 y CD3
|
|
DK2857419T3
(da)
|
2012-05-30 |
2021-03-29 |
Chugai Pharmaceutical Co Ltd |
Antigen-bindende molekyle til eliminering af aggregerede antigener
|
|
WO2014004586A1
(en)
|
2012-06-25 |
2014-01-03 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
|
AU2013289883B2
(en)
*
|
2012-07-13 |
2018-11-01 |
Zymeworks Bc Inc. |
Bispecific asymmetric heterodimers comprising anti-CD3 constructs
|
|
CN104640561A
(zh)
|
2012-07-23 |
2015-05-20 |
酵活有限公司 |
包含轻链和重链的选择性配对的免疫球蛋白构建体
|
|
US9682143B2
(en)
*
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
|
JOP20200236A1
(ar)
*
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
CN107892719B
(zh)
|
2012-10-04 |
2022-01-14 |
达纳－法伯癌症研究所公司 |
人单克隆抗-pd-l1抗体和使用方法
|
|
EP2904016B1
(en)
|
2012-10-08 |
2018-11-14 |
Roche Glycart AG |
Fc-free antibodies comprising two fab-fragments and methods of use
|
|
WO2014078866A2
(en)
*
|
2012-11-19 |
2014-05-22 |
Xencor, Inc. |
Engineered immunoglobulins with extended in vivo half-life
|
|
JP6571527B2
(ja)
|
2012-11-21 |
2019-09-04 |
ウーハン ワイゼットワイ バイオファルマ カンパニー リミテッドＷｕｈａｎ Ｙｚｙ Ｂｉｏｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． |
二重特異性抗体
|
|
CN104955953B
(zh)
*
|
2012-11-27 |
2019-04-26 |
亚洲大学校产学协力团 |
高效诱导抗体重链恒定区的异源二聚体形成的ch3域变体对，其制备方法及用途
|
|
US20140377269A1
(en)
|
2012-12-19 |
2014-12-25 |
Adimab, Llc |
Multivalent antibody analogs, and methods of their preparation and use
|
|
US10968276B2
(en)
*
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9605084B2
(en)
*
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CN105051069B
(zh)
|
2013-01-14 |
2019-12-10 |
Xencor股份有限公司 |
新型异二聚体蛋白
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9738722B2
(en)
|
2013-01-15 |
2017-08-22 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
US9458245B2
(en)
|
2013-03-06 |
2016-10-04 |
Merrimack Pharmaceuticals, Inc. |
ANTI-C-MET tandem Fc bispecific antibodies
|
|
AU2014249243C1
(en)
|
2013-03-13 |
2019-08-08 |
Imaginab, Inc. |
Antigen binding constructs to CD8
|
|
US10544187B2
(en)
|
2013-03-15 |
2020-01-28 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
EP2970484B2
(en)
|
2013-03-15 |
2022-09-21 |
Amgen Inc. |
Heterodimeric bispecific antibodies
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
WO2014145806A2
(en)
*
|
2013-03-15 |
2014-09-18 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US20160145355A1
(en)
|
2013-06-24 |
2016-05-26 |
Biomed Valley Discoveries, Inc. |
Bispecific antibodies
|
|
GB201311487D0
(en)
|
2013-06-27 |
2013-08-14 |
Alligator Bioscience Ab |
Bispecific molecules
|
|
PL3444271T3
(pl)
|
2013-08-08 |
2022-03-07 |
Cytune Pharma |
Modulokiny oparte na il-15 i domenie sushi il-15ralfa
|
|
AR097306A1
(es)
|
2013-08-20 |
2016-03-02 |
Merck Sharp & Dohme |
Modulación de la inmunidad tumoral
|
|
EP2839842A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
|
|
US10258887B2
(en)
|
2013-10-25 |
2019-04-16 |
Voyetra Turtle Beach, Inc. |
Method and system for a headset with parental control
|
|
MY176522A
(en)
|
2013-11-04 |
2020-08-13 |
Ichnos Sciences SA |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
|
PE20210107A1
(es)
|
2013-12-17 |
2021-01-19 |
Genentech Inc |
Anticuerpos anti-cd3 y metodos de uso
|
|
CA2933881A1
(en)
|
2013-12-17 |
2015-06-25 |
Genentech, Inc. |
Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
|
|
BR112016013963A2
(pt)
|
2013-12-17 |
2017-10-10 |
Genentech Inc |
terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1
|
|
DK3089994T3
(da)
|
2013-12-30 |
2022-07-04 |
Epimab Biotherapeutics Inc |
Fabs-in-tandem-immunglobulin og anvendelser deraf
|
|
MX374391B
(es)
|
2014-01-08 |
2025-03-06 |
Shanghai hengrui pharmaceutical co ltd |
Proteina heterodimérica il-15 y usos de la misma.
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
GB201402631D0
(en)
|
2014-02-14 |
2014-04-02 |
Alligator Bioscience Ab |
Library
|
|
US9603927B2
(en)
|
2014-02-28 |
2017-03-28 |
Janssen Biotech, Inc. |
Combination therapies with anti-CD38 antibodies
|
|
TWI701042B
(zh)
|
2014-03-19 |
2020-08-11 |
美商再生元醫藥公司 |
用於腫瘤治療之方法及抗體組成物
|
|
EP3122781B1
(en)
|
2014-03-28 |
2020-01-01 |
Xencor, Inc. |
Bispecific antibodies that bind to cd38 and cd3
|
|
RU2577226C2
(ru)
|
2014-04-10 |
2016-03-10 |
Общество с ограниченной ответственностью, "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") |
Способ получения биспецифических антител против cd3*cd19 формата флексибоди в клетках млекопитающих
|
|
CN107073090A
(zh)
|
2014-04-30 |
2017-08-18 |
哈佛学院董事会 |
结合的疫苗装置和杀死癌细胞的方法
|
|
SG10201913324PA
(en)
|
2014-05-29 |
2020-03-30 |
Macrogenics Inc |
Tri-specific binding molecules and methods of use thereof
|
|
AU2015292326A1
(en)
|
2014-07-24 |
2017-02-23 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
PL3177644T3
(pl)
|
2014-08-05 |
2021-06-14 |
MabQuest SA |
Immunologiczne reagenty wiążące do PD-1
|
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
|
ES2791248T3
(es)
|
2014-08-19 |
2020-11-03 |
Novartis Ag |
Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer
|
|
SG11201701867SA
(en)
|
2014-09-09 |
2017-04-27 |
Janssen Biotech Inc |
Combination therapies with anti-cd38 antibodies
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
CA2964367C
(en)
|
2014-10-14 |
2024-01-30 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
MA40894A
(fr)
|
2014-11-04 |
2017-09-12 |
Glenmark Pharmaceuticals Sa |
Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production
|
|
DK4141032T3
(da)
|
2014-11-20 |
2024-08-05 |
Hoffmann La Roche |
Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler og PD-1-aksebindende antagonister
|
|
AU2015353416C1
(en)
|
2014-11-26 |
2022-01-27 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and CD38
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
WO2016086186A2
(en)
|
2014-11-26 |
2016-06-02 |
Xencor, Inc. |
Heterodimeric antibodies including binding to cd8
|
|
EP3223845B1
(en)
|
2014-11-26 |
2021-05-19 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cd20
|
|
CA2874083C
(en)
|
2014-12-05 |
2024-01-02 |
Universite Laval |
Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
|
|
EP3237449A2
(en)
*
|
2014-12-22 |
2017-11-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
CN117843799A
(zh)
|
2015-01-08 |
2024-04-09 |
生物技术公司 |
激动性tnf受体结合剂
|
|
AU2016206707A1
(en)
|
2015-01-14 |
2017-08-10 |
Compass Therapeutics Llc |
Multispecific immunomodulatory antigen-binding constructs
|
|
MA41414A
(fr)
|
2015-01-28 |
2017-12-05 |
Centre Nat Rech Scient |
Protéines de liaison agonistes d' icos
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
CA2984134A1
(en)
*
|
2015-05-08 |
2016-11-17 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and tumor antigens
|
|
EP3313441B1
(en)
|
2015-06-24 |
2024-02-21 |
Janssen Biotech, Inc. |
Immune modulation and treatment of solid tumors with antibodies that specifically bind cd38
|
|
SI3328419T1
(sl)
|
2015-07-30 |
2021-11-30 |
Macrogenics, Inc. |
PD-1-vezavne molekule in postopki uporabe le-teh
|
|
JOP20160154B1
(ar)
|
2015-07-31 |
2021-08-17 |
Regeneron Pharma |
أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
|
|
TW202346349A
(zh)
|
2015-07-31 |
2023-12-01 |
德商安美基研究（慕尼黑）公司 |
Dll3及cd3抗體構築體
|
|
TWI796283B
(zh)
|
2015-07-31 |
2023-03-21 |
德商安美基研究（慕尼黑）公司 |
Ｍｓｌｎ及ｃｄ３抗體構築體
|
|
SG10202101909RA
(en)
|
2015-08-07 |
2021-04-29 |
Alx Oncology Inc |
Constructs having a sirp-alpha domain or variant thereof
|
|
AU2016312015A1
(en)
|
2015-08-21 |
2018-04-12 |
Crage Medical Co., Limited |
Fully human anti-mesothelin antibodies and immune effector cells targeting mesothelin
|
|
EP3355920A4
(en)
|
2015-09-29 |
2019-05-15 |
Celgene Corporation |
PD-1 BINDING PROTEINS AND METHOD OF USE THEREOF
|
|
WO2017055391A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Bispecific t cell activating antigen binding molecules binding mesothelin and cd3
|
|
EP3368577A1
(en)
|
2015-10-30 |
2018-09-05 |
NBE-Therapeutics AG |
Anti-mesothelin antibodies
|
|
US20180305465A1
(en)
|
2015-11-25 |
2018-10-25 |
Amgen Inc. |
Heterodimeric antibodies that bind cd3 and cd38
|
|
WO2017100372A1
(en)
|
2015-12-07 |
2017-06-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and psma
|
|
BR112018012801B1
(pt)
|
2015-12-22 |
2024-03-12 |
Regeneron Pharmaceuticals, Inc |
Usos de uma combinação de anticorpos anti-pd-1 e anticorpos biespecíficos anti-cd20/anti-cd3 e de uma composição farmacêutica
|
|
LT3411404T
(lt)
|
2016-02-03 |
2022-12-27 |
Amgen Research (Munich) Gmbh |
Psma ir cd3 bispecifiniai, t ląsteles aktyvuojantys antikūno konstruktai
|
|
KR20230091191A
(ko)
|
2016-05-27 |
2023-06-22 |
아게누스 인코포레이티드 |
항-tim-3 항체 및 이의 사용 방법
|
|
EP3464370A1
(en)
|
2016-06-01 |
2019-04-10 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma
|
|
EP3464365A1
(en)
|
2016-06-01 |
2019-04-10 |
Xencor, Inc. |
Bispecific antibodies that bind cd123 and cd3
|
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
EP3463464A4
(en)
|
2016-06-07 |
2020-07-01 |
MacroGenics, Inc. |
ASSOCIATION TREATMENT
|
|
WO2017218707A2
(en)
|
2016-06-14 |
2017-12-21 |
Xencor, Inc. |
Bispecific checkpoint inhibitor antibodies
|
|
WO2017220989A1
(en)
|
2016-06-20 |
2017-12-28 |
Kymab Limited |
Anti-pd-l1 and il-2 cytokines
|
|
US10316088B2
(en)
|
2016-06-28 |
2019-06-11 |
Xencor, Inc. |
Heterodimeric antibodies that bind somatostatin receptor 2
|
|
TW201815825A
(zh)
|
2016-07-21 |
2018-05-01 |
財團法人生物技術開發中心 |
經修飾之抗原結合fab片段及包含其之抗原結合分子
|
|
JP2019532621A
(ja)
|
2016-08-29 |
2019-11-14 |
サイオクサス セラピューティクス リミテッド |
二重特異性Ｔ細胞エンゲージャー（ＢｉＴＥ）で武装したアデノウイルス
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
CN107840891A
(zh)
|
2016-09-19 |
2018-03-27 |
上海吉倍生物技术有限公司 |
高亲和力的抗msln抗体及其应用
|
|
MA46534A
(fr)
|
2016-10-14 |
2019-08-21 |
Xencor Inc |
Protéines de fusion fc hétérodimères il15/il15r
|
|
KR20250044934A
(ko)
|
2016-10-19 |
2025-04-01 |
인벤라 인코포레이티드 |
항체 구조물
|
|
US11111305B2
(en)
|
2017-01-09 |
2021-09-07 |
Torch Therapeutics |
Method of using a bispecific antibody to conditionally inhibit a receptor signaling complex
|
|
EP3621648A4
(en)
|
2017-05-12 |
2021-01-20 |
Harpoon Therapeutics, Inc. |
TRISPECIFIC PROTEINS MSLN AND METHOD OF USE
|
|
AU2018275109A1
(en)
*
|
2017-06-01 |
2020-01-02 |
Xencor, Inc. |
Bispecific antibodies that bind CD 123 CD3
|
|
WO2018223004A1
(en)
*
|
2017-06-01 |
2018-12-06 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3
|
|
WO2019050521A1
(en)
|
2017-09-07 |
2019-03-14 |
Macrogenics, Inc. |
DOSAGE SCHEMES OF BISPECIFIC DIACORPS CD123 X CD3 IN THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES
|
|
US11186649B2
(en)
|
2017-10-10 |
2021-11-30 |
Sanofi |
Anti-CD38 antibodies and methods of use
|
|
AU2018366199A1
(en)
|
2017-11-08 |
2020-05-28 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
CA3082283A1
(en)
|
2017-11-21 |
2019-05-31 |
Novartis Ag |
Trispecific binding molecules against tumor-associated antigens and uses thereof
|
|
US10780120B2
(en)
|
2018-03-06 |
2020-09-22 |
The Trustees Of The University Of Pennsylvania |
Prostate-specific membrane antigen cars and methods of use thereof
|
|
CA3096052A1
(en)
|
2018-04-04 |
2019-10-10 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
US10869888B2
(en)
|
2018-04-17 |
2020-12-22 |
Innovative Cellular Therapeutics CO., LTD. |
Modified cell expansion and uses thereof
|
|
CA3097741A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
|
US20190352362A1
(en)
|
2018-04-18 |
2019-11-21 |
Xencor, Inc. |
LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
|
|
EP3802609A2
(en)
|
2018-05-24 |
2021-04-14 |
Janssen Biotech, Inc. |
Psma binding agents and uses thereof
|
|
UY38289A
(es)
|
2018-07-02 |
2020-01-31 |
Amgen Inc |
Proteína de unión al antígeno anti-steap1
|
|
US12195533B2
(en)
|
2018-07-24 |
2025-01-14 |
Inhibrx Biosciences, Inc. |
Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same
|
|
JP2021534096A
(ja)
|
2018-08-08 |
2021-12-09 |
ドラゴンフライ セラピューティクス， インコーポレイテッド |
Ｎｋｇ２ｄ、ｃｄ１６および腫瘍関連抗原に結合するタンパク質
|
|
BR112021016955A2
(pt)
|
2019-03-01 |
2021-11-23 |
Xencor Inc |
Composição, composição de ácido nucleico, composição de vetor de expressão, vetor de expressão, célula hospedeira, métodos de produção de um domínio de ligação de membro de família 3 de pirofosfatase/fosfodiesterase de ectonucleotídeo e de tratamento de um câncer, anticorpo anti-enpp3, e, anticorpo heterodimérico
|
|
EP3972993A1
(en)
|
2019-05-21 |
2022-03-30 |
Novartis AG |
Variant cd58 domains and uses thereof
|
|
WO2021026387A2
(en)
|
2019-08-06 |
2021-02-11 |
Xencor, Inc. |
HETERODIMERIC IgG-LIKE BISPECIFIC ANTIBODIES
|
|
IL298159A
(en)
|
2020-05-13 |
2023-01-01 |
Pfizer |
Treatment methods and uses for cancer treatment
|
|
AU2021329378A1
(en)
|
2020-08-19 |
2023-03-23 |
Xencor, Inc. |
Anti-CD28 compositions
|
|
US12462008B2
(en)
|
2021-04-23 |
2025-11-04 |
Beijing Boe Technology Development Co., Ltd. |
Unlocking control method and device, electronic apparatus, and computer-readable storage medium
|
|
US20240025968A1
(en)
|
2022-04-07 |
2024-01-25 |
Xencor, Inc. |
LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
|