|
CA2647846C
(en)
|
2006-03-31 |
2016-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
CN106519025B
(zh)
|
2007-09-26 |
2021-04-23 |
中外制药株式会社 |
利用cdr的氨基酸取代来改变抗体等电点的方法
|
|
CA2721052C
(en)
|
2008-04-11 |
2023-02-21 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
|
EP3029066B1
(en)
|
2010-07-29 |
2019-02-20 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
BR112013013354A2
(pt)
|
2010-11-30 |
2020-10-06 |
Chugai Seiyaku Kabushiki Kaisha |
molécula de ligação ao antígeno capaz de se ligar a uma pluralidade de moléculas de antígeno repetidamente
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
JP6774164B2
(ja)
|
2012-08-24 |
2020-10-21 |
中外製薬株式会社 |
マウスＦｃγＲＩＩ特異的Ｆｃ抗体
|
|
JP6501521B2
(ja)
|
2012-08-24 |
2019-04-17 |
中外製薬株式会社 |
ＦｃγＲＩＩｂ特異的Ｆｃ領域改変体
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CA2898100C
(en)
|
2013-01-14 |
2023-10-10 |
Xencor, Inc. |
Novel heterodimeric proteins
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
WO2014113510A1
(en)
|
2013-01-15 |
2014-07-24 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CA2903258C
(en)
|
2013-03-15 |
2019-11-26 |
Amgen Inc. |
Heterodimeric bispecific antibodies
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
JP6594855B2
(ja)
|
2013-03-15 |
2019-10-23 |
ゼンコア インコーポレイテッド |
ヘテロ二量体タンパク質
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
EP3421495A3
(en)
|
2013-03-15 |
2019-05-15 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
EP2970508A4
(en)
*
|
2013-03-15 |
2016-12-14 |
Permeon Biologics Inc |
GENETICALLY MODIFIED LOADING ANTIBODIES OR ENHANCED ENHANCEMENT ENHANCEMENT TARGETING PROTEIN COMPOSITIONS AND METHODS OF USE
|
|
CA2908350C
(en)
|
2013-04-02 |
2023-08-08 |
Futa Mimoto |
Fc region variant
|
|
US11261262B2
(en)
|
2013-09-03 |
2022-03-01 |
Novimmune Sa |
Readily isolated bispecific binding molecules with native format having mutated constant regions
|
|
JP2016538275A
(ja)
*
|
2013-11-04 |
2016-12-08 |
グレンマーク ファーマシューティカルズ， エセ．アー． |
Ｔ細胞再標的化ヘテロ二量体免疫グロブリン（ｈｅｔｅｒｏ−ｄｉｍｅｒｉｃ ｉｍｍｕｎｏｇｌｏｂｕｌｉｎ）の製造
|
|
MX385936B
(es)
|
2014-03-28 |
2025-03-11 |
Xencor Inc |
Anticuerpos biespecíficos que se unen a cd38 y cd3.
|
|
CU20170041A7
(es)
*
|
2014-09-26 |
2017-09-06 |
Macrogenics Inc |
Diacuerpos monovalentes biespecíficos que son capaces de unir cd19 y cd3
|
|
JP6993228B2
(ja)
*
|
2014-11-19 |
2022-03-03 |
ジェネンテック， インコーポレイテッド |
抗トランスフェリン受容体／抗ｂａｃｅ１多重特異性抗体および使用方法
|
|
JP6859259B2
(ja)
|
2014-11-19 |
2021-04-14 |
ジェネンテック， インコーポレイテッド |
ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
MX2017006918A
(es)
|
2014-11-26 |
2018-01-25 |
Xencor Inc |
Anticuerpos heterodimericos que se unen a cd3 y cd38.
|
|
US20160176969A1
(en)
*
|
2014-11-26 |
2016-06-23 |
Xencor, Inc. |
Heterodimeric antibodies including binding to cd8
|
|
HRP20211273T1
(hr)
*
|
2014-11-26 |
2021-11-12 |
Xencor, Inc. |
Heterodimerna protutijela koja vežu cd3 i cd20
|
|
MY181199A
(en)
|
2014-12-19 |
2020-12-21 |
Chugai Pharmaceutical Co Ltd |
Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
|
|
EP3237449A2
(en)
*
|
2014-12-22 |
2017-11-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
CN107108729A
(zh)
|
2015-02-05 |
2017-08-29 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il‑8‑结合抗体，及其应用
|
|
WO2016141387A1
(en)
|
2015-03-05 |
2016-09-09 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
EA036156B1
(ru)
*
|
2015-05-08 |
2020-10-07 |
Ксенкор, Инк. |
Гетеродимерные антитела, которые связывают cd3 и опухолевые антигены
|
|
JP7058219B2
(ja)
|
2015-12-07 |
2022-04-21 |
ゼンコア インコーポレイテッド |
Ｃｄ３及びｐｓｍａに結合するヘテロ二量体抗体
|
|
KR102850929B1
(ko)
|
2015-12-09 |
2025-08-27 |
에프. 호프만-라 로슈 아게 |
항-약물 항체의 형성을 감소시키기 위한 ii형 항-cd20 항체
|
|
WO2017110981A1
(en)
|
2015-12-25 |
2017-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
|
EP3464370A1
(en)
|
2016-06-01 |
2019-04-10 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma
|
|
US20170349660A1
(en)
|
2016-06-01 |
2017-12-07 |
Xencor. Inc. |
Bispecific antibodies that bind cd123 and cd3
|
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
CN110603266A
(zh)
|
2016-06-02 |
2019-12-20 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的ii型抗cd20抗体和抗cd20/cd3双特异性抗体
|
|
FI3468586T3
(fi)
|
2016-06-14 |
2024-10-29 |
Xencor Inc |
Bispesifisiä immuuniaktivaatiota vapauttavia vasta-aineita
|
|
EP3475304B1
(en)
|
2016-06-28 |
2022-03-23 |
Xencor, Inc. |
Heterodimeric antibodies that bind somatostatin receptor 2
|
|
JP6527643B2
(ja)
|
2016-08-05 |
2019-06-05 |
中外製薬株式会社 |
Ｉｌ−８関連疾患の治療用又は予防用組成物
|
|
DK3507306T3
(da)
*
|
2016-08-30 |
2025-10-20 |
Xencor Inc |
Bispecifikke immunmodulatoriske antistoffer, der binder co-stimulerende og checkpoint-receptorer
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
WO2018045110A1
(en)
|
2016-08-30 |
2018-03-08 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
CA3040504A1
(en)
*
|
2016-10-14 |
2018-04-19 |
Xencor, Inc. |
Il15/il15ra heterodimeric fc-fusion proteins
|
|
JP7250677B2
(ja)
|
2016-12-22 |
2023-04-03 |
キュー バイオファーマ， インコーポレイテッド |
Ｔ細胞調節多量体ポリペプチド及びその使用方法
|
|
US11851471B2
(en)
|
2017-01-09 |
2023-12-26 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
EP3565833A1
(en)
|
2017-01-09 |
2019-11-13 |
Torch Therapeutics |
Conditionally effective bispecific therapeutics
|
|
IL268554B2
(en)
|
2017-02-08 |
2025-03-01 |
Dragonfly Therapeutics Inc |
Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
|
|
CA3235295C
(en)
*
|
2017-02-20 |
2024-11-19 |
Dragonfly Therapeutics, Inc. |
Proteins binding her2, nkg2d and cd16
|
|
EP3583131A4
(en)
*
|
2017-02-20 |
2021-03-17 |
Dragonfly Therapeutics, Inc. |
PROTEINS THAT BIND CD33, NKG2D AND CD16
|
|
KR102619015B1
(ko)
|
2017-03-15 |
2023-12-28 |
큐 바이오파마, 인크. |
면역 반응을 조절하는 방법
|
|
TW202515920A
(zh)
|
2017-04-11 |
2025-04-16 |
美商因荷布瑞克斯生物科學公司 |
具有經受限cd3結合的多重特異性多肽構築體及使用其之方法
|
|
EP3615068A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
WO2018223002A1
(en)
|
2017-06-01 |
2018-12-06 |
Xencor, Inc. |
Bispecific antibodies that bind cd 123 cd3
|
|
WO2018223004A1
(en)
|
2017-06-01 |
2018-12-06 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3
|
|
EP3409322A1
(en)
|
2017-06-01 |
2018-12-05 |
F. Hoffmann-La Roche AG |
Treatment method
|
|
UY37758A
(es)
|
2017-06-12 |
2019-01-31 |
Novartis Ag |
Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
|
|
MA49517A
(fr)
|
2017-06-30 |
2020-05-06 |
Xencor Inc |
Protéines de fusion fc hétérodimères ciblées contenant il-15/il-15ra et domaines de liaison à l'antigène
|
|
JP2020531438A
(ja)
*
|
2017-08-16 |
2020-11-05 |
ドラゴンフライ セラピューティクス， インコーポレイテッド |
Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質
|
|
RU2020111554A
(ru)
*
|
2017-08-23 |
2021-09-23 |
Драгонфлай Терапьютикс, Инк. |
Белки, связывающие nkg2d, cd16 и опухолеассоциированный антиген
|
|
CN111094356B
(zh)
|
2017-09-25 |
2022-11-01 |
苏州丁孚靶点生物技术有限公司 |
一种蛋白质异二聚体及其用途
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
WO2019094637A1
(en)
|
2017-11-08 |
2019-05-16 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-pd-1 sequences
|
|
KR102722731B1
(ko)
|
2017-12-19 |
2024-10-25 |
젠코어 인코포레이티드 |
조작된 il-2 fc 융합 단백질
|
|
US12384847B2
(en)
|
2018-02-08 |
2025-08-12 |
Dragonfly Therapeutics, Inc. |
Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen
|
|
JP7407118B2
(ja)
|
2018-02-08 |
2023-12-28 |
アムジェン インコーポレイテッド |
低ｐＨ医薬抗体製剤
|
|
US11884733B2
(en)
*
|
2018-02-08 |
2024-01-30 |
Dragonfly Therapeutics, Inc. |
Antibody variable domains targeting the NKG2D receptor
|
|
US12215157B2
(en)
*
|
2018-02-20 |
2025-02-04 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use
|
|
IL277375B2
(en)
|
2018-03-15 |
2025-08-01 |
Chugai Pharmaceutical Co Ltd |
Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
|
|
CN112469477A
(zh)
|
2018-04-04 |
2021-03-09 |
Xencor股份有限公司 |
与成纤维细胞活化蛋白结合的异源二聚体抗体
|
|
CA3095093A1
(en)
*
|
2018-04-05 |
2019-10-10 |
Novartis Ag |
Trispecific binding molecules against cancers and uses thereof
|
|
KR20210006913A
(ko)
|
2018-04-11 |
2021-01-19 |
인히브릭스, 인크. |
제한된 ｃｄ3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도
|
|
CA3097741A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
|
IL310398A
(en)
|
2018-04-18 |
2024-03-01 |
Xencor Inc |
Proteins from heterodimeric il-15/il-15rα fc and their uses
|
|
EP3781597A1
(en)
|
2018-04-18 |
2021-02-24 |
Xencor, Inc. |
Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
|
|
JP2021521784A
(ja)
|
2018-04-18 |
2021-08-30 |
ゼンコア インコーポレイテッド |
ＩＬ−１５／ＩＬ−１５ＲａＦｃ融合タンパク質とＰＤ−１抗原結合ドメインを含むＰＤ−１標的化ヘテロダイマー融合タンパク質およびそれらの使用
|
|
EP3784350A1
(en)
|
2018-04-27 |
2021-03-03 |
Novartis Ag |
Dosing of a bispecific antibody that bind cd123 and cd3
|
|
EA202091977A1
(ru)
*
|
2018-05-28 |
2021-02-09 |
Драгонфлай Терапьютикс, Инк. |
Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
|
|
US20210205449A1
(en)
|
2018-06-01 |
2021-07-08 |
Novartis Ag |
Dosing of a bispecific antibody that bind cd123 and cd3
|
|
JP7398396B2
(ja)
|
2018-06-01 |
2023-12-14 |
ノバルティス アーゲー |
Ｂｃｍａに対する結合分子及びその使用
|
|
MX2020012797A
(es)
|
2018-06-01 |
2021-03-25 |
Compugen Ltd |
Anticuerpos biespecificos anti-pvrig/anti-tigit y métodos de uso.
|
|
JP7439372B2
(ja)
*
|
2018-06-21 |
2024-02-28 |
シャタック ラボ，インコーポレイテッド |
ヘテロ二量体タンパク質及びその使用
|
|
TW202019965A
(zh)
|
2018-07-16 |
2020-06-01 |
美商安進公司 |
治療多發性骨髓瘤之方法
|
|
TW202035451A
(zh)
|
2018-07-24 |
2020-10-01 |
美商英伊布里克斯公司 |
含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法
|
|
MA53284A
(fr)
|
2018-08-08 |
2022-01-26 |
Dragonfly Therapeutics Inc |
Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur
|
|
EP3833392A4
(en)
|
2018-08-08 |
2022-05-18 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
|
|
EA202091888A1
(ru)
*
|
2018-08-08 |
2020-10-23 |
Драгонфлай Терапьютикс, Инк. |
Вариабельные домены антител, нацеленные на рецептор nkg2d
|
|
SG11202103192RA
(en)
|
2018-10-03 |
2021-04-29 |
Xencor Inc |
Il-12 heterodimeric fc-fusion proteins
|
|
US20210340273A1
(en)
|
2018-10-11 |
2021-11-04 |
Inhlbrx, inc. |
5t4 single domain antibodies and therapeutic compositions thereof
|
|
CA3115082A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
B7h3 single domain antibodies and therapeutic compositions thereof
|
|
CA3115089A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
Dll3 single domain antibodies and therapeutic compositions thereof
|
|
CA3116188A1
(en)
|
2018-10-12 |
2020-04-16 |
Xencor, Inc. |
Pd-1 targeted il-15/il-15ralpha fc fusion proteins and uses in combination therapies thereof
|
|
CN112969714B
(zh)
|
2018-11-30 |
2022-11-22 |
江苏恒瑞医药股份有限公司 |
抗cd40抗体、其抗原结合片段及其医药用途
|
|
WO2020114479A1
(zh)
*
|
2018-12-07 |
2020-06-11 |
江苏恒瑞医药股份有限公司 |
多特异性蛋白分子
|
|
US11618776B2
(en)
|
2018-12-20 |
2023-04-04 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15RA and NKG2D antigen binding domains
|
|
US12006345B2
(en)
|
2019-02-21 |
2024-06-11 |
Xencor, Inc. |
Untargeted and targeted IL-10 Fc-fusion proteins
|
|
MX2021010390A
(es)
|
2019-03-01 |
2021-11-17 |
Xencor Inc |
Anticuerpos heterodimericos que se unen a enpp3 y cd3.
|
|
WO2020205516A1
(en)
|
2019-03-29 |
2020-10-08 |
Xencor, Inc. |
Dosing of a bispecific antibody that binds pd1 and ctla4
|
|
BR112021022405A2
(pt)
*
|
2019-05-09 |
2022-04-19 |
Merus Nv |
Domínios variantes para multimerização de proteínas e separação das mesmas
|
|
AU2020279112A1
(en)
|
2019-05-17 |
2021-12-02 |
Xencor, Inc. |
IL-7-Fc-fusion proteins
|
|
KR20220012296A
(ko)
|
2019-05-20 |
2022-02-03 |
싸이튠 파마 |
암 또는 감염성 질환 치료를 위한 IL-2/IL-15Rβγ 작용제 투여 요법
|
|
EP3972998A1
(en)
|
2019-05-21 |
2022-03-30 |
Novartis AG |
Cd19 binding molecules and uses thereof
|
|
US20220396631A1
(en)
|
2019-05-21 |
2022-12-15 |
Lu HUANG |
Trispecific binding molecules against bcma and uses thereof
|
|
EP3972993A1
(en)
|
2019-05-21 |
2022-03-30 |
Novartis AG |
Variant cd58 domains and uses thereof
|
|
WO2020243315A1
(en)
*
|
2019-05-29 |
2020-12-03 |
Cue Biopharma, Inc. |
Multimeric t-cell modulatory polypeptides and methods of use thereof
|
|
EP3976644A4
(en)
|
2019-05-31 |
2022-12-14 |
The Johns Hopkins University |
BI-SPECIFIC LIAISONS
|
|
EP3976649A4
(en)
*
|
2019-05-31 |
2022-12-14 |
The Johns Hopkins University |
B-SPECIFIC IL-6Ra/IL-8R BINDING AGENTS TO BLOCK MIGRATION OF CANCER CELLS
|
|
CN114008082A
(zh)
*
|
2019-06-24 |
2022-02-01 |
南京金斯瑞生物科技有限公司 |
单克隆抗体-细胞因子融合蛋白二聚体及其应用
|
|
US20210102002A1
(en)
|
2019-08-06 |
2021-04-08 |
Xencor, Inc. |
HETERODIMERIC IgG-LIKE BISPECIFIC ANTIBODIES
|
|
CN115916233A
(zh)
|
2019-10-03 |
2023-04-04 |
Xencor股份有限公司 |
靶向IL-12异源二聚体Fc融合蛋白
|
|
TW202128757A
(zh)
|
2019-10-11 |
2021-08-01 |
美商建南德克公司 |
具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
|
|
WO2021122866A1
(en)
|
2019-12-17 |
2021-06-24 |
Ose Immunotherapeutics |
Bifunctional molecules comprising an il-7 variant
|
|
MX2022009101A
(es)
*
|
2020-01-23 |
2022-10-07 |
Adagene Ag |
Proteinas heterodimericas con mutaciones fc.
|
|
MX2022009306A
(es)
|
2020-01-29 |
2022-09-26 |
Inhibrx Inc |
Loseta de nucleo de espuma densificada (dfc) con linea de anticuerpos de dominio individual de cd28 y constructos multivalentes y multiespecíficas de los mismos.
|
|
WO2021171264A1
(en)
|
2020-02-28 |
2021-09-02 |
Novartis Ag |
Dosing of a bispecific antibody that binds cd123 and cd3
|
|
US11365239B2
(en)
|
2020-03-20 |
2022-06-21 |
Tsb Therapeutics (Beijing) Co., Ltd. |
Anti-SARS-COV-2 antibodies and uses thereof
|
|
US20230128499A1
(en)
|
2020-03-27 |
2023-04-27 |
Novartis Ag |
Bispecific combination therapy for treating proliferative diseases and autoimmune diseases
|
|
TW202208428A
(zh)
|
2020-05-06 |
2022-03-01 |
美商蜻蜓醫療公司 |
結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質
|
|
MX2022014166A
(es)
|
2020-05-11 |
2022-12-02 |
Janssen Biotech Inc |
Metodos para tratar el mieloma multiple.
|
|
CA3169949A1
(en)
|
2020-05-12 |
2021-11-18 |
Cue Biopharma, Inc. |
Multimeric t-cell modulatory polypeptides and methods of use thereof
|
|
WO2021231976A1
(en)
|
2020-05-14 |
2021-11-18 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
|
|
US20220106403A1
(en)
|
2020-05-14 |
2022-04-07 |
Xencor, Inc. |
Heterodimeric antibodies that bind msln and cd3
|
|
EP4154910A4
(en)
*
|
2020-06-30 |
2024-09-11 |
Harbour Biomed (Shanghai) Co., Ltd |
Binding protein having h2l2 and hcab structures
|
|
KR20220014531A
(ko)
*
|
2020-07-29 |
2022-02-07 |
(주)메디톡스 |
헤테로이량체 Ｆｃ 융합 단백질, 및 관련 조성물, 용도 및 방법
|
|
WO2022040482A1
(en)
|
2020-08-19 |
2022-02-24 |
Xencor, Inc. |
Anti-cd28 and/or anti-b7h3 compositions
|
|
JP2023541366A
(ja)
|
2020-09-09 |
2023-10-02 |
キュー バイオファーマ， インコーポレイテッド |
１型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法
|
|
WO2022061240A1
(en)
*
|
2020-09-21 |
2022-03-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Heteromultimeric proteins for reducing ige-dependent allergic effector cell activation
|
|
CA3198590A1
(en)
|
2020-10-13 |
2022-04-21 |
Rajkumar Ganesan |
Bioengineered t cell mediated immunity, materials and other methods for modulating cluster of differentiation iv &/or viii
|
|
WO2022081886A1
(en)
|
2020-10-14 |
2022-04-21 |
Xencor, Inc. |
Bispecific antibodies that bind pd-l1 and cd28
|
|
EP4232478A1
(en)
|
2020-10-23 |
2023-08-30 |
Xencor, Inc. |
Anti-cd20 antibodies and therapeutic uses thereof
|
|
WO2022090202A1
(en)
|
2020-10-26 |
2022-05-05 |
Cytune Pharma |
IL-2/IL-15RBβү AGONIST FOR TREATING NON-MELANOMA SKIN CANCER
|
|
JP2023550685A
(ja)
|
2020-10-26 |
2023-12-05 |
サイチューン ファーマ |
扁平上皮癌を治療するためのＩＬ－２／ＩＬ－１５Ｒβγアゴニスト
|
|
IL302412A
(en)
|
2020-11-06 |
2023-06-01 |
Novartis Ag |
Anti-CD19 and B-cell targeting agent combination therapy for the treatment of B-cell malignancies
|
|
IL302569A
(en)
|
2020-11-06 |
2023-07-01 |
Novartis Ag |
Cd19 binding molecules and uses thereof
|
|
JP2023547499A
(ja)
*
|
2020-11-06 |
2023-11-10 |
ノバルティス アーゲー |
抗体Ｆｃ変異体
|
|
US20220144956A1
(en)
|
2020-11-06 |
2022-05-12 |
Xencor, Inc. |
HETERODIMERIC ANTIBODIES THAT BIND TGFbetaRII
|
|
KR20230118573A
(ko)
*
|
2020-11-11 |
2023-08-11 |
에이치큐 한 |
액티빈/tgf-베타 및 rankl의 이작용성 길항제 및 이의 용도
|
|
CA3201729A1
(en)
|
2020-12-17 |
2022-06-23 |
Nicolas Poirier |
Bifunctional anti-pd1/il-7 molecules
|
|
US20220227867A1
(en)
|
2020-12-24 |
2022-07-21 |
Xencor, Inc. |
ICOS TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND ICOS ANTIGEN BINDING DOMAINS
|
|
EP4301774A4
(en)
|
2021-03-03 |
2025-08-13 |
Dragonfly Therapeutics Inc |
METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
|
|
CN117157319A
(zh)
|
2021-03-09 |
2023-12-01 |
Xencor股份有限公司 |
结合cd3和cldn6的异二聚抗体
|
|
KR20230154311A
(ko)
|
2021-03-10 |
2023-11-07 |
젠코어 인코포레이티드 |
Cd3 및 gpc3에 결합하는 이종이량체 항체
|
|
WO2022214653A1
(en)
|
2021-04-09 |
2022-10-13 |
Ose Immunotherapeutics |
New scaffold for bifunctional molecules with improved properties
|
|
EP4320156A1
(en)
|
2021-04-09 |
2024-02-14 |
Ose Immunotherapeutics |
Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
|
|
JP7651145B2
(ja)
*
|
2021-04-20 |
2025-03-26 |
コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション |
向上した癌細胞死滅効能を有する非対称抗体
|
|
TW202241968A
(zh)
|
2021-04-22 |
2022-11-01 |
大陸商廣東菲鵬制藥股份有限公司 |
雙特異性多功能融合多肽
|
|
EP4329800A1
(en)
|
2021-04-30 |
2024-03-06 |
F. Hoffmann-La Roche AG |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
|
|
TW202243689A
(zh)
|
2021-04-30 |
2022-11-16 |
瑞士商赫孚孟拉羅股份公司 |
抗ｃｄ２０／抗ｃｄ３雙特異性抗體及抗ｃｄ７８ｂ抗體藥物結合物的組合治療之給藥
|
|
US20240247062A1
(en)
|
2021-06-15 |
2024-07-25 |
Xencor, Inc. |
Heterodimeric antibodies that bind claudin18.2 and cd3
|
|
TW202306989A
(zh)
|
2021-06-22 |
2023-02-16 |
瑞士商諾華公司 |
用於在治療化膿性汗腺炎中使用的雙特異性抗體
|
|
EP4359428A2
(en)
*
|
2021-06-23 |
2024-05-01 |
Cytune Pharma |
Interleukin-15 based immunocytokines
|
|
AU2022302143A1
(en)
|
2021-07-02 |
2024-01-18 |
Yale University |
Compositions and methods for treating cancers
|
|
WO2023010021A1
(en)
|
2021-07-27 |
2023-02-02 |
Xencor, Inc. |
Il-18-fc fusion proteins
|
|
EP4384204A1
(en)
|
2021-08-13 |
2024-06-19 |
Cytune Pharma |
Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer
|
|
JP2024535705A
(ja)
*
|
2021-08-25 |
2024-10-02 |
バイオグラフ ５５，インク． |
免疫抑制性ｂ細胞を標的化する抗体
|
|
WO2023028159A1
(en)
*
|
2021-08-25 |
2023-03-02 |
Biograph 55, Inc. |
Methods of treating cancers associated with immunosuppressive b cells
|
|
EP4395832A1
(en)
|
2021-08-31 |
2024-07-10 |
Yale University |
Compositions and methods for treating cancers
|
|
WO2023049922A1
(en)
|
2021-09-27 |
2023-03-30 |
Xencor, Inc. |
B-cell maturation antigen (bcma) binding domain compositions
|
|
IL312503A
(en)
|
2021-11-03 |
2024-07-01 |
Janssen Biotech Inc |
Methods of treating cancers and enhancing efficacy of bcmaxcd3 bispecific antibodies
|
|
WO2023081915A1
(en)
|
2021-11-08 |
2023-05-11 |
Xencor, Inc. |
Il-8 as a predictive biomarker and methods of use thereof for the treatment of cancer
|
|
EP4448570A1
(en)
|
2021-12-14 |
2024-10-23 |
CDR-Life AG |
Dual mhc-targeting t cell engager
|
|
MX2024010339A
(es)
|
2022-02-23 |
2024-09-30 |
Xencor Inc |
Anticuerpos anti-cd28 x anti-psma.
|
|
MX2024011468A
(es)
|
2022-03-23 |
2024-09-25 |
Hoffmann La Roche |
Tratamiento conjunto de un anticuerpo biespecifico anti-cd20/anti-cd3 y quimioterapia.
|
|
US20240025968A1
(en)
|
2022-04-07 |
2024-01-25 |
Xencor, Inc. |
LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
|
|
US20230383012A1
(en)
|
2022-04-13 |
2023-11-30 |
Xencor, Inc. |
Antibodies that bind pd-l1, pd-l2, and/or cd28
|
|
EP4508081A1
(en)
|
2022-04-13 |
2025-02-19 |
F. Hoffmann-La Roche AG |
Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use
|
|
PE20251172A1
(es)
|
2022-04-26 |
2025-04-23 |
Novartis Ag |
Anticuerpos multiespecificos que se dirigen a il-13 e il-18
|
|
CN119677773A
(zh)
|
2022-07-01 |
2025-03-21 |
爱尔开-阿贝优公司 |
Ige-fceri的置换物
|
|
WO2024028386A1
(en)
|
2022-08-02 |
2024-02-08 |
Ose Immunotherapeutics |
Multifunctional molecule directed against cd28
|
|
CN120202015A
(zh)
|
2022-09-14 |
2025-06-24 |
Cdr-生物科技股份有限公司 |
Mage-a4肽双重t细胞衔接子
|
|
WO2024088987A1
(en)
|
2022-10-26 |
2024-05-02 |
F. Hoffmann-La Roche Ag |
Combination therapy for the treatment of cancer
|
|
WO2024102645A1
(en)
|
2022-11-07 |
2024-05-16 |
Xencor, Inc. |
Combination treatment with a bispecific antibody that binds ctla4 and pd1 for prostate cancer
|
|
US20240166705A1
(en)
|
2022-11-07 |
2024-05-23 |
Xencor, Inc. |
Il18-fc fusion proteins
|
|
WO2024102948A1
(en)
|
2022-11-11 |
2024-05-16 |
Celgene Corporation |
Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
|
|
US12173081B2
(en)
|
2023-03-21 |
2024-12-24 |
Biograph 55, Inc. |
CD19/CD38 multispecific antibodies
|
|
WO2024215989A1
(en)
|
2023-04-14 |
2024-10-17 |
Sotio Biotech Inc. |
ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS
|
|
WO2025038668A1
(en)
|
2023-08-14 |
2025-02-20 |
Voro Therapeutics, Inc. |
Therapeutic binding agents that conditionally promote myeloid cell activity against target cells and uses thereof
|
|
TW202525853A
(zh)
|
2023-08-28 |
2025-07-01 |
美商山可爾股份有限公司 |
抗ｃｄ２０ｘ抗ｃｄ２８組合療法
|
|
WO2025068957A1
(en)
|
2023-09-29 |
2025-04-03 |
Novartis Ag |
Bispecific antibodies for use in lowering the risk of cardiovascular disease events in subjects known to be a carrier of clonal expansion of hematopoietic cell lines with somatic mutations
|
|
WO2025075057A1
(ja)
*
|
2023-10-02 |
2025-04-10 |
国立大学法人 熊本大学 |
ポリペプチドの会合体形成抑制方法
|
|
WO2025085447A1
(en)
|
2023-10-17 |
2025-04-24 |
Xencor, Inc. |
Pd-1 targeted il18-fc fusion proteins
|
|
WO2025157132A1
(en)
|
2024-01-23 |
2025-07-31 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Multispecific antibodies targeting cd3, cd19 and cd20 and uses thereof
|
|
WO2025183172A1
(ja)
*
|
2024-02-28 |
2025-09-04 |
旭化成株式会社 |
等電点が改変されたドメインを有する抗体
|
|
WO2025210181A1
(en)
|
2024-04-04 |
2025-10-09 |
Cdr-Life Ag |
Antigen binding proteins targeting an hla-restricted kk-lc-1 peptide
|
|
WO2025215160A1
(en)
|
2024-04-11 |
2025-10-16 |
Cdr-Life Ag |
Antigen binding proteins targeting an hla-restricted prame peptide
|
|
WO2025240670A2
(en)
|
2024-05-15 |
2025-11-20 |
Abalytics Oncology, Inc. |
Anti-pd-1 antibodies and related binding molecules and methods and uses thereof
|
|
WO2025242836A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders
|
|
WO2025242835A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of cancer
|
|
US20250361311A1
(en)
|
2024-05-24 |
2025-11-27 |
Xencor, Inc. |
Anti-tnf-like ligand 1a (tl1a) antibodies
|
|
WO2025255405A1
(en)
|
2024-06-06 |
2025-12-11 |
Bristol-Myers Squibb Company |
Anti-fap antibodies and uses thereof
|
|
WO2025255349A1
(en)
|
2024-06-06 |
2025-12-11 |
Bristol-Myers Squibb Company |
Multispecific anti-cd40 / anti-fap antibodies and uses thereof
|