JP2020506898A5 - - Google Patents
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- JP2020506898A5 JP2020506898A5 JP2019538383A JP2019538383A JP2020506898A5 JP 2020506898 A5 JP2020506898 A5 JP 2020506898A5 JP 2019538383 A JP2019538383 A JP 2019538383A JP 2019538383 A JP2019538383 A JP 2019538383A JP 2020506898 A5 JP2020506898 A5 JP 2020506898A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- polypeptide
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022168448A JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
| JP2024194438A JP2025024012A (ja) | 2017-01-17 | 2024-11-06 | 改善された血清アルブミン結合剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762446992P | 2017-01-17 | 2017-01-17 | |
| US62/446,992 | 2017-01-17 | ||
| PCT/EP2018/051082 WO2018134234A1 (en) | 2017-01-17 | 2018-01-17 | Improved serum albumin binders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022168448A Division JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506898A JP2020506898A (ja) | 2020-03-05 |
| JP2020506898A5 true JP2020506898A5 (OSRAM) | 2021-01-07 |
| JP7300385B2 JP7300385B2 (ja) | 2023-06-29 |
Family
ID=61163666
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538383A Active JP7300385B2 (ja) | 2017-01-17 | 2018-01-17 | 改善された血清アルブミン結合剤 |
| JP2022168448A Active JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
| JP2024194438A Pending JP2025024012A (ja) | 2017-01-17 | 2024-11-06 | 改善された血清アルブミン結合剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022168448A Active JP7585272B2 (ja) | 2017-01-17 | 2022-10-20 | 改善された血清アルブミン結合剤 |
| JP2024194438A Pending JP2025024012A (ja) | 2017-01-17 | 2024-11-06 | 改善された血清アルブミン結合剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11897944B2 (OSRAM) |
| EP (3) | EP4442708A3 (OSRAM) |
| JP (3) | JP7300385B2 (OSRAM) |
| KR (2) | KR20230165374A (OSRAM) |
| CN (2) | CN117327175A (OSRAM) |
| AU (2) | AU2018209150B2 (OSRAM) |
| BR (1) | BR112019014600A2 (OSRAM) |
| CA (1) | CA3050574A1 (OSRAM) |
| DK (1) | DK3571224T3 (OSRAM) |
| ES (1) | ES2994387T3 (OSRAM) |
| FI (1) | FI3571224T3 (OSRAM) |
| HR (1) | HRP20241501T1 (OSRAM) |
| HU (1) | HUE068820T2 (OSRAM) |
| IL (3) | IL267897B2 (OSRAM) |
| LT (1) | LT3571224T (OSRAM) |
| MX (4) | MX2019008536A (OSRAM) |
| PL (1) | PL3571224T3 (OSRAM) |
| PT (1) | PT3571224T (OSRAM) |
| RS (1) | RS66173B1 (OSRAM) |
| SG (2) | SG10202108973SA (OSRAM) |
| SI (1) | SI3571224T1 (OSRAM) |
| WO (1) | WO2018134234A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250099289A (ko) | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| SG10201810124PA (en) | 2014-05-16 | 2018-12-28 | Ablynx Nv | Improved immunoglobulin variable domains |
| RU2765384C2 (ru) * | 2016-12-07 | 2022-01-28 | Аблинкс Нв | Улучшенные одиночные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| BR112019014600A2 (pt) * | 2017-01-17 | 2020-02-18 | Ablynx N.V. | Ligantes de albumina sérica melhorados |
| DK3571225T3 (da) * | 2017-01-17 | 2024-11-04 | Ablynx Nv | Forbedrede serumalbuminbindere |
| CN114980923A (zh) | 2019-12-06 | 2022-08-30 | 艾伯霖克斯公司 | 包含靶向TNFα和OX40L的免疫球蛋白单可变结构域的多肽 |
| WO2021110816A1 (en) | 2019-12-06 | 2021-06-10 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TNFα AND IL-23 |
| MY208649A (en) | 2019-12-09 | 2025-05-22 | Sanofi Sa | Polypeptides comprising immunoglobulin single variable domains targeting il-13 and tslp |
| US20230136595A1 (en) | 2020-03-30 | 2023-05-04 | Ablynx Nv | Method for the production and purification of multivalent immunoglobulin single variable domains |
| KR20230074527A (ko) | 2020-09-25 | 2023-05-30 | 아블린쓰 엔.브이. | Il-13 및 ox40l을 표적으로 하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩티드 |
| EP4237438A4 (en) * | 2020-10-27 | 2024-11-27 | Beijing QL Biopharmaceutical Co., Ltd. | GDF15 FUSION PROTEINS AND THEIR USE |
| PH12023500009A1 (en) | 2020-12-18 | 2024-03-11 | Ablynx Nv | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| EP4262985A1 (en) | 2020-12-18 | 2023-10-25 | Ablynx N.V. | Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor |
| WO2022129572A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha |
| JP2024546916A (ja) | 2021-12-17 | 2024-12-26 | アブリンクス エン．ヴェー． | ＴＣＲαβ、ＣＤ３３及びＣＤ１２３を標的とする免疫グロブリン単一可変ドメインを含むポリペプチド |
| CN119604536A (zh) * | 2022-05-23 | 2025-03-11 | 塞雷乌斯股份有限公司 | Her2结合剂及其用途 |
| AU2023290487A1 (en) | 2022-06-14 | 2025-01-30 | Ablynx Nv | Immunoglobulin single variable domains targeting t cell receptor |
| TW202423965A (zh) | 2022-07-27 | 2024-06-16 | 比利時商艾伯霖克斯公司 | 與新生兒fc受體的特定表位結合之多肽 |
| TW202440614A (zh) | 2022-12-23 | 2024-10-16 | 比利時商艾伯霖克斯公司 | 基於蛋白質的接合載體 |
| CN120529914A (zh) | 2023-01-09 | 2025-08-22 | 奥德赛治疗股份有限公司 | 抗tnfr2抗原结合蛋白及其用途 |
| CN120712282A (zh) | 2023-02-17 | 2025-09-26 | 阿布林克斯有限公司 | 结合新生儿fc受体的多肽 |
| TW202444757A (zh) | 2023-03-14 | 2024-11-16 | 美商奧迪希治療公司 | 抗cd25抗原結合蛋白及其用途 |
| AU2024273077A1 (en) | 2023-05-17 | 2025-11-13 | Odyssey Therapeutics, Inc. | Modified single-domain antibodies |
| WO2024261235A1 (en) | 2023-06-22 | 2024-12-26 | Ablynx Nv | Chimeric proteins for modulating cytokine receptor activity |
| AR133108A1 (es) | 2023-06-29 | 2025-08-27 | Odyssey Therapeutics Inc | Proteínas de unión a antígeno anti-trailr2 y sus usos |
| TW202517676A (zh) | 2023-07-05 | 2025-05-01 | 比利時商艾伯霖克斯公司 | 用於治療ＩｇＧ相關疾病及病症之改良ＦｃＲｎ拮抗劑 |
| TW202525843A (zh) | 2023-09-04 | 2025-07-01 | 法商賽諾菲公司 | 用於治療表現磷脂醯肌醇蛋白聚糖-3之腫瘤的多肽 |
| WO2025061919A1 (en) | 2023-09-22 | 2025-03-27 | Ablynx Nv | Bi- and multivalent albumin binders |
| TW202530265A (zh) | 2023-10-13 | 2025-08-01 | 美商奧迪希治療公司 | 抗cdh17抗原結合蛋白及其用途 |
| WO2025099632A1 (en) | 2023-11-08 | 2025-05-15 | Sanofi | Cd25 based lysosomal degrader and uses thereof |
| US20250296991A1 (en) | 2023-12-01 | 2025-09-25 | Ablynx N.V. | Precision activated polypeptides |
| WO2025133253A2 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based conjugation carriers for intranuclear delivery |
| WO2025133166A1 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based carriers for site-specific amine conjugation |
| WO2025217240A1 (en) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
| WO2025255558A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Anti-thymic stromal lymphopoietin (tslp) antigen-binding proteins and uses thereof |
| WO2025255435A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Antigen-binding proteins against serum albumin and uses thereof |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| EP1027439B1 (en) | 1997-10-27 | 2010-03-17 | Bac Ip B.V. | Multivalent antigen-binding proteins |
| US6742038B2 (en) | 2000-04-07 | 2004-05-25 | Danger, Inc. | System and method of linking user identification to a subscriber identification module |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| DE60305919T2 (de) | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| NZ540194A (en) | 2002-11-08 | 2008-07-31 | Ablynx Nv | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| JP2006517789A (ja) | 2003-01-10 | 2006-08-03 | アブリンクス エン．ヴェー． | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
| KR20070086896A (ko) | 2004-12-02 | 2007-08-27 | 도만티스 리미티드 | 항ｉｌ1ｒ1 단일 도메인 항체 및 치료적 용도 |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| PL2444424T3 (pl) | 2005-05-20 | 2019-01-31 | Ablynx N.V. | Ulepszone Nanociała TM do leczenia zaburzeń, w których pośredniczy agregacja |
| CA2629850A1 (en) | 2005-12-01 | 2007-06-07 | Domantis Limited | Competitive domain antibody formats that bind interleukin 1 receptor type 1 |
| AU2006321364B2 (en) | 2005-12-01 | 2011-11-10 | Domantis Limited | Noncompetitive domain antibody formats that bind Interleukin 1 Receptor type 1 |
| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
| AU2007209201A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
| US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
| EP2069402A2 (en) | 2006-09-08 | 2009-06-17 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| NZ581097A (en) | 2007-05-24 | 2012-03-30 | Ablynx Nv | Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders |
| CA2706200A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Immunoglobulin constructs comprising multiple single variable domains and an fc portion |
| DE102008023620A1 (de) | 2008-05-15 | 2009-11-19 | Mettler-Toledo (Albstadt) Gmbh | Funktionseinheit mit einer aufrufbaren Funktion und Verfahren zu deren Aufruf |
| MX2010012518A (es) | 2008-05-16 | 2010-12-06 | Ablynx Nv | Secuencias de aminoacidos dirigidas contra cxcr4 y otros receptores acoplados a proteina g y compuestos que comprenden los mismos. |
| CN102164965B (zh) * | 2008-09-26 | 2016-03-30 | Ucb医药有限公司 | 生物产品 |
| WO2010130832A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| MX2012000765A (es) | 2009-07-16 | 2012-02-13 | Glaxo Group Ltd | Dominios variables sencillos de union de albumina anti-suero mejorados. |
| CA2774552A1 (en) | 2009-09-30 | 2011-04-07 | Glaxo Group Limited | Drug fusions and conjugates with extended half life |
| EP2603522A1 (en) | 2010-08-13 | 2013-06-19 | GlaxoSmithKline Intellectual Property Development Limited | Improved anti-serum albumin binding variants |
| WO2012022703A2 (en) | 2010-08-20 | 2012-02-23 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| EP2621953B1 (en) * | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| US11644471B2 (en) * | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP4218933A1 (en) | 2011-06-23 | 2023-08-02 | Ablynx NV | Serum albumin binding proteins |
| US20150344568A1 (en) * | 2011-06-23 | 2015-12-03 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| PL2723769T5 (pl) * | 2011-06-23 | 2022-10-17 | Ablynx Nv | Techniki przewidywania, wykrywania i redukcji niespecyficznej interferencji białka w testach z udziałem pojedynczych domen zmiennych immunoglobuliny |
| WO2012174741A1 (en) | 2011-06-24 | 2012-12-27 | Google Inc. | Determining cross-language query suggestion based on query translations |
| MY167125A (en) | 2011-08-17 | 2018-08-13 | Glaxo Group Ltd | Modified proteins and peptides |
| US20130129727A1 (en) * | 2011-11-17 | 2013-05-23 | Nanjingjinsirui Science & Technology Biology Corporation | Methods and systems for increasing protein stability |
| WO2014037419A1 (en) * | 2012-09-04 | 2014-03-13 | Vib Vzw | Immunoglobulin single variable domains directed against cd74 and uses derived thereof |
| US20140186365A1 (en) * | 2013-01-03 | 2014-07-03 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Antibodies that specifically bind to serum albumin without interfering with albumin's capability to interact with the fcrn |
| WO2014111550A1 (en) | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
| SG10201810124PA (en) | 2014-05-16 | 2018-12-28 | Ablynx Nv | Improved immunoglobulin variable domains |
| CN114478753A (zh) | 2015-01-21 | 2022-05-13 | 英伊布里克斯公司 | 非免疫原性单结构域抗体 |
| LT3611192T (lt) | 2015-05-13 | 2025-06-25 | Ablynx N.V. | T ląstelių rekrutingo polipeptidai tcr alfa/beta reaktyvumo pagrindu |
| MA46023A (fr) | 2015-10-22 | 2019-07-03 | Modernatx Inc | Vaccin contre le virus de la grippe à large spectre |
| BR112018010802A2 (pt) | 2015-11-27 | 2018-11-27 | Ablynx Nv | polipeptídeos que inibem cd40l |
| WO2017189964A2 (en) * | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| RU2765384C2 (ru) * | 2016-12-07 | 2022-01-28 | Аблинкс Нв | Улучшенные одиночные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| DK3571225T3 (da) * | 2017-01-17 | 2024-11-04 | Ablynx Nv | Forbedrede serumalbuminbindere |
| BR112019014600A2 (pt) * | 2017-01-17 | 2020-02-18 | Ablynx N.V. | Ligantes de albumina sérica melhorados |
-
2018
- 2018-01-17 BR BR112019014600-8A patent/BR112019014600A2/pt unknown
- 2018-01-17 AU AU2018209150A patent/AU2018209150B2/en active Active
- 2018-01-17 IL IL267897A patent/IL267897B2/en unknown
- 2018-01-17 HR HRP20241501TT patent/HRP20241501T1/hr unknown
- 2018-01-17 KR KR1020237040677A patent/KR20230165374A/ko not_active Ceased
- 2018-01-17 RS RS20241239A patent/RS66173B1/sr unknown
- 2018-01-17 EP EP24191390.4A patent/EP4442708A3/en active Pending
- 2018-01-17 PL PL18703213.1T patent/PL3571224T3/pl unknown
- 2018-01-17 SI SI201831172T patent/SI3571224T1/sl unknown
- 2018-01-17 FI FIEP18703213.1T patent/FI3571224T3/fi active
- 2018-01-17 ES ES18703213T patent/ES2994387T3/es active Active
- 2018-01-17 WO PCT/EP2018/051082 patent/WO2018134234A1/en not_active Ceased
- 2018-01-17 EP EP24191396.1A patent/EP4471058A3/en active Pending
- 2018-01-17 CA CA3050574A patent/CA3050574A1/en active Pending
- 2018-01-17 CN CN202311114345.5A patent/CN117327175A/zh active Pending
- 2018-01-17 DK DK18703213.1T patent/DK3571224T3/da active
- 2018-01-17 IL IL316293A patent/IL316293A/en unknown
- 2018-01-17 EP EP18703213.1A patent/EP3571224B1/en active Active
- 2018-01-17 US US16/477,927 patent/US11897944B2/en active Active
- 2018-01-17 HU HUE18703213A patent/HUE068820T2/hu unknown
- 2018-01-17 JP JP2019538383A patent/JP7300385B2/ja active Active
- 2018-01-17 SG SG10202108973SA patent/SG10202108973SA/en unknown
- 2018-01-17 PT PT187032131T patent/PT3571224T/pt unknown
- 2018-01-17 LT LTEPPCT/EP2018/051082T patent/LT3571224T/lt unknown
- 2018-01-17 KR KR1020197024114A patent/KR102653724B1/ko active Active
- 2018-01-17 CN CN201880015687.2A patent/CN110461870B/zh active Active
- 2018-01-17 MX MX2019008536A patent/MX2019008536A/es unknown
- 2018-01-17 IL IL305912A patent/IL305912B2/en unknown
- 2018-01-17 SG SG11201906341XA patent/SG11201906341XA/en unknown
-
2019
- 2019-07-17 MX MX2025010630A patent/MX2025010630A/es unknown
- 2019-07-17 MX MX2024013316A patent/MX2024013316A/es unknown
- 2019-07-17 MX MX2024008521A patent/MX2024008521A/es unknown
-
2022
- 2022-10-20 JP JP2022168448A patent/JP7585272B2/ja active Active
-
2024
- 2024-01-04 US US18/404,145 patent/US20240294617A1/en active Pending
- 2024-11-06 JP JP2024194438A patent/JP2025024012A/ja active Pending
-
2025
- 2025-04-07 AU AU2025202453A patent/AU2025202453A1/en active Pending
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