JP2017528488A - がんの処置のための併用療法 - Google Patents

がんの処置のための併用療法 Download PDF

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Publication number
JP2017528488A
JP2017528488A JP2017515060A JP2017515060A JP2017528488A JP 2017528488 A JP2017528488 A JP 2017528488A JP 2017515060 A JP2017515060 A JP 2017515060A JP 2017515060 A JP2017515060 A JP 2017515060A JP 2017528488 A JP2017528488 A JP 2017528488A
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Prior art keywords
alkyl
compound
inhibitor
kras
additional therapeutic
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JP2017528488A5 (enExample
Inventor
マシュー ロバート ジェーンズ，
マシュー ロバート ジェーンズ，
マシュー ピーター パトリセリ，
マシュー ピーター パトリセリ，
リアンシェン リー，
リアンシェン リー，
ピンダ レン，
ピンダ レン，
イー リウ，
イー リウ，
Original Assignee
アラクセス ファーマ エルエルシー
アラクセス ファーマ エルエルシー
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Publication of JP2017528488A publication Critical patent/JP2017528488A/ja
Publication of JP2017528488A5 publication Critical patent/JP2017528488A5/ja
Priority to JP2022142265A priority Critical patent/JP2022168089A/ja
Priority to JP2024106300A priority patent/JP2024114976A/ja
Priority to JP2024106299A priority patent/JP2024114975A/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2017515060A 2014-09-18 2015-09-18 がんの処置のための併用療法 Withdrawn JP2017528488A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022142265A JP2022168089A (ja) 2014-09-18 2022-09-07 がんの処置のための併用療法
JP2024106300A JP2024114976A (ja) 2014-09-18 2024-07-01 がんの処置のための併用療法
JP2024106299A JP2024114975A (ja) 2014-09-18 2024-07-01 がんの処置のための併用療法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462052332P 2014-09-18 2014-09-18
US62/052,332 2014-09-18
US201562195633P 2015-07-22 2015-07-22
US62/195,633 2015-07-22
PCT/US2015/051030 WO2016044772A1 (en) 2014-09-18 2015-09-18 Combination therapies for treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022142265A Division JP2022168089A (ja) 2014-09-18 2022-09-07 がんの処置のための併用療法

Publications (2)

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JP2017528488A true JP2017528488A (ja) 2017-09-28
JP2017528488A5 JP2017528488A5 (enExample) 2018-11-01

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JP2017515060A Withdrawn JP2017528488A (ja) 2014-09-18 2015-09-18 がんの処置のための併用療法
JP2022142265A Withdrawn JP2022168089A (ja) 2014-09-18 2022-09-07 がんの処置のための併用療法
JP2024106299A Pending JP2024114975A (ja) 2014-09-18 2024-07-01 がんの処置のための併用療法
JP2024106300A Pending JP2024114976A (ja) 2014-09-18 2024-07-01 がんの処置のための併用療法

Family Applications After (3)

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JP2022142265A Withdrawn JP2022168089A (ja) 2014-09-18 2022-09-07 がんの処置のための併用療法
JP2024106299A Pending JP2024114975A (ja) 2014-09-18 2024-07-01 がんの処置のための併用療法
JP2024106300A Pending JP2024114976A (ja) 2014-09-18 2024-07-01 がんの処置のための併用療法

Country Status (8)

Country Link
US (2) US10111874B2 (enExample)
EP (1) EP3193851B1 (enExample)
JP (4) JP2017528488A (enExample)
ES (1) ES2835729T3 (enExample)
JO (1) JO3556B1 (enExample)
TW (1) TWI694837B (enExample)
UY (1) UY36307A (enExample)
WO (1) WO2016044772A1 (enExample)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018513853A (ja) * 2015-04-10 2018-05-31 アラクセス ファーマ エルエルシー 置換キナゾリン化合物およびその使用方法
JP2020105162A (ja) * 2018-11-19 2020-07-09 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
JP2021505640A (ja) * 2018-10-15 2021-02-18 イーライ リリー アンド カンパニー Ｋｒａｓ ｇ１２ｃ阻害剤
JP2021100960A (ja) * 2016-12-22 2021-07-08 アムジエン・インコーポレーテツド 肺がん、膵臓がん、または大腸がんを治療するためのＫＲＡＳ Ｇ１２Ｃ阻害剤としての、ベンズイソチアゾール、イソチアゾロ［３，４−ｂ］ピリジン、キナゾリン、フタラジン、ピリド［２，３−ｄ］ピリダジンおよびピリド［２，３−ｄ］ピリミジン誘導体
JP2021521194A (ja) * 2018-05-04 2021-08-26 アムジエン・インコーポレーテツド ＫＲａｓ Ｇ１２Ｃ阻害剤及びそれを使用する方法
JP2021532061A (ja) * 2018-05-08 2021-11-25 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag 四環式ヘテロアリール化合物
JP2022500385A (ja) * 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
JP2022500379A (ja) * 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
JP2022500381A (ja) * 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
JP2022500384A (ja) * 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
JP2022517222A (ja) * 2019-01-10 2022-03-07 ミラティ セラピューティクス， インコーポレイテッド Ｋｒａｓ ｇ１２ｃ阻害剤
JP2022546043A (ja) * 2019-08-29 2022-11-02 ミラティ セラピューティクス， インコーポレイテッド Ｋｒａｓ ｇ１２ｄ阻害剤
JP2023505056A (ja) * 2019-11-27 2023-02-08 ターニング・ポイント・セラピューティクス・インコーポレイテッド ジアリール大環状化合物を含む併用療法
JP2023550028A (ja) * 2020-11-13 2023-11-30 ジェネンテック， インコーポレイテッド 固形腫瘍を治療するためのｋｒａｓｇ１２ｃ阻害剤及びｖｅｇｆ阻害剤を含む方法及び組成物
JP2024500326A (ja) * 2020-12-08 2024-01-09 ジェネンテック， インコーポレイテッド 固形腫瘍を治療するためのｋｒａｓｇ１２ｃ阻害剤及びｅｇｆｒ阻害剤を含む方法及び組成物

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