|
US4309430A
(en)
|
1980-06-27 |
1982-01-05 |
Merck & Co., Inc. |
Pyrazinyl-1,2,4-oxadiazole-5-ones, for treatment of edema, and processes for preparing same
|
|
US5329012A
(en)
|
1987-10-29 |
1994-07-12 |
The Research Foundation Of State University Of New York |
Bis(acyloxmethyl)imidazole compounds
|
|
JP2597917B2
(ja)
|
1990-04-26 |
1997-04-09 |
富士写真フイルム株式会社 |
新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料
|
|
DE59608203D1
(de)
|
1995-05-09 |
2001-12-20 |
Basf Ag |
PYRAZOLO- 1,5a]-PYRIMIDINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG
|
|
WO1997043267A1
(en)
|
1996-05-11 |
1997-11-20 |
Kings College London |
Pyrazines
|
|
US6060478A
(en)
|
1996-07-24 |
2000-05-09 |
Dupont Pharmaceuticals |
Azolo triazines and pyrimidines
|
|
HU229024B1
(en)
|
1996-07-24 |
2013-07-29 |
Bristol Myers Squibb Pharma Co |
Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
|
|
US6191131B1
(en)
|
1997-07-23 |
2001-02-20 |
Dupont Pharmaceuticals Company |
Azolo triazines and pyrimidines
|
|
JPH10218881A
(ja)
|
1997-02-03 |
1998-08-18 |
Pola Chem Ind Inc |
新規なピロロピラゾロピリミジン誘導体
|
|
JP2002241379A
(ja)
|
1997-03-21 |
2002-08-28 |
Dainippon Pharmaceut Co Ltd |
３−オキサジアゾリルキノキサリン誘導体
|
|
AU734009B2
(en)
|
1997-05-30 |
2001-05-31 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
US6235741B1
(en)
|
1997-05-30 |
2001-05-22 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
|
CA2336832A1
(en)
|
1998-07-16 |
2000-01-27 |
Shionogi & Co., Ltd. |
Pyrimidine derivatives exhibiting antitumor activity
|
|
US6245759B1
(en)
|
1999-03-11 |
2001-06-12 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
JP2001302666A
(ja)
|
1999-09-21 |
2001-10-31 |
Nissan Chem Ind Ltd |
アゾール縮合ヘテロ環アニライド化合物及び除草剤
|
|
MY125533A
(en)
|
1999-12-06 |
2006-08-30 |
Bristol Myers Squibb Co |
Heterocyclic dihydropyrimidine compounds
|
|
CN1272328C
(zh)
|
1999-12-17 |
2006-08-30 |
希龙公司 |
糖元合成酶激酶3的基于吡嗪的抑制剂
|
|
US6723332B2
(en)
|
2000-05-26 |
2004-04-20 |
Neurogen Corporation |
Oxomidazopyridine-carboxamides
|
|
US20020041880A1
(en)
|
2000-07-05 |
2002-04-11 |
Defeo-Jones Deborah |
Method of treating cancer
|
|
US6849660B1
(en)
|
2000-08-01 |
2005-02-01 |
Isis Pharmaceuticals, Inc. |
Antimicrobial biaryl compounds
|
|
US7067520B2
(en)
|
2000-11-17 |
2006-06-27 |
Ishihara Sangyo Kaisha, Ltd. |
Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
|
|
EP1217000A1
(en)
|
2000-12-23 |
2002-06-26 |
Aventis Pharma Deutschland GmbH |
Inhibitors of factor Xa and factor VIIa
|
|
GB0103926D0
(en)
|
2001-02-17 |
2001-04-04 |
Astrazeneca Ab |
Chemical compounds
|
|
ATE409181T1
(de)
|
2001-05-08 |
2008-10-15 |
Univ Yale |
Proteomimetische verbindungen und verfahren
|
|
EP1463742A4
(en)
|
2001-06-21 |
2006-05-10 |
Ariad Pharma Inc |
NEW PYRAZOLO AND PYRROLO PYRIMIDINES AND THEIR USES
|
|
SE0102439D0
(sv)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
|
SE0102438D0
(sv)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
|
WO2003037900A2
(en)
|
2001-11-01 |
2003-05-08 |
Icagen, Inc. |
Pyrazolopyrimidines
|
|
US6992087B2
(en)
|
2001-11-21 |
2006-01-31 |
Pfizer Inc |
Substituted aryl 1,4-pyrazine derivatives
|
|
AU2002343557A1
(en)
|
2001-11-21 |
2003-06-10 |
Pharmacia And Upjohn Company |
Substituted aryl 1,4-pyrazine derivatives
|
|
KR20040084896A
(ko)
|
2002-02-06 |
2004-10-06 |
버텍스 파마슈티칼스 인코포레이티드 |
Ｇｓｋ-3의 억제제로서 유용한 헤테로아릴 화합물
|
|
MXPA04007775A
(es)
|
2002-03-13 |
2004-10-15 |
Janssen Pharmaceutica Nv |
Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa.
|
|
GB0206860D0
(en)
|
2002-03-22 |
2002-05-01 |
Glaxo Group Ltd |
Compounds
|
|
TWI319387B
(en)
|
2002-04-05 |
2010-01-11 |
Astrazeneca Ab |
Benzamide derivatives
|
|
GB0209715D0
(en)
|
2002-04-27 |
2002-06-05 |
Astrazeneca Ab |
Chemical compounds
|
|
JP4901102B2
(ja)
|
2002-05-03 |
2012-03-21 |
エクセリクシス， インク． |
プロテインキナーゼモジュレーターおよびその使用方法
|
|
US7704995B2
(en)
|
2002-05-03 |
2010-04-27 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
|
CN1656079A
(zh)
|
2002-05-31 |
2005-08-17 |
卫材株式会社 |
吡唑化合物和含有该化合物的药物组合物
|
|
AU2003240488A1
(en)
|
2002-06-04 |
2003-12-19 |
Neogenesis Pharmaceuticals, Inc. |
Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
|
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
|
US7015227B2
(en)
|
2002-06-21 |
2006-03-21 |
Cgi Pharmaceuticals, Inc. |
Certain amino-substituted monocycles as kinase modulators
|
|
WO2004022559A1
(en)
|
2002-09-04 |
2004-03-18 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
EP1537116B1
(en)
|
2002-09-04 |
2010-06-02 |
Schering Corporation |
Pyrazolopyrimidines suitable for the treatment of cancer diseases
|
|
US7205308B2
(en)
|
2002-09-04 |
2007-04-17 |
Schering Corporation |
Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
US7601724B2
(en)
|
2002-09-04 |
2009-10-13 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
TWI335919B
(en)
|
2002-09-04 |
2011-01-11 |
Schering Corp |
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
CN1701073B
(zh)
|
2002-09-04 |
2011-06-22 |
先灵公司 |
作为细胞周期蛋白依赖激酶抑制剂的吡唑并[1,5-a]嘧啶
|
|
US8580782B2
(en)
|
2002-09-04 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
|
US7196092B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corporation |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
US8673924B2
(en)
|
2002-09-04 |
2014-03-18 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
|
US7563798B2
(en)
|
2002-09-04 |
2009-07-21 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
US7196078B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corpoartion |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
US7119200B2
(en)
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
AU2003282679A1
(en)
|
2002-10-04 |
2004-05-04 |
Arena Pharmaceuticals, Inc. |
Hydroxypyrazoles for use against metabolic-related disorders
|
|
WO2004052315A2
(en)
|
2002-12-11 |
2004-06-24 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
SE0203754D0
(sv)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
|
SE0203752D0
(sv)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
|
GEP20084341B
(en)
|
2003-02-26 |
2008-03-25 |
Sugen Inc |
Aminoheteroaryl compounds as protein kinase inhibitors
|
|
EP1599482A4
(en)
|
2003-02-28 |
2008-10-01 |
Teijin Pharma Ltd |
PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
|
|
JP2006519833A
(ja)
|
2003-03-11 |
2006-08-31 |
ファイザー・プロダクツ・インク |
トランスフォーミング成長因子（ｔｇｆ）阻害剤としてのピラジン化合物
|
|
JP2006520794A
(ja)
|
2003-03-21 |
2006-09-14 |
スミスクライン ビーチャム コーポレーション |
化合物
|
|
US20060293339A1
(en)
|
2003-03-24 |
2006-12-28 |
Chakravarty Prasun K |
Biaryl substituted 6-membered heterocycles as sodium channel blockers
|
|
GB2400101A
(en)
|
2003-03-28 |
2004-10-06 |
Biofocus Discovery Ltd |
Compounds capable of binding to the active site of protein kinases
|
|
JP2006528980A
(ja)
|
2003-05-15 |
2006-12-28 |
メルク エンド カムパニー インコーポレーテッド |
Ｓ１ｐ受容体作働薬としての３−（２−アミノ−１−アザシクロ）−５−アリール−１，２，４−オキサジアゾール類
|
|
AR045595A1
(es)
|
2003-09-04 |
2005-11-02 |
Vertex Pharma |
Composiciones utiles como inhibidores de proteinas quinasas
|
|
EP2145888A1
(en)
|
2003-09-18 |
2010-01-20 |
Conforma Therapeutics Corporation |
Deazapurine derivatives as HSP90-Inhibitors
|
|
WO2005034952A2
(en)
|
2003-10-07 |
2005-04-21 |
The Feinstein Institute For Medical Research |
Isoxazole and isothiazole compounds useful in the treatment of inflammation
|
|
CN1905873A
(zh)
|
2003-11-19 |
2007-01-31 |
阵列生物制药公司 |
Mek的杂环抑制剂及其使用方法
|
|
DE10356579A1
(de)
|
2003-12-04 |
2005-07-07 |
Merck Patent Gmbh |
Aminderivate
|
|
JP2007524682A
(ja)
|
2004-02-12 |
2007-08-30 |
メルク エンド カムパニー インコーポレーテッド |
代謝調節型グルタミン酸受容体−５の調節物質としてのビピリジルアミド
|
|
EP1720879A2
(de)
|
2004-02-25 |
2006-11-15 |
Basf Aktiengesellschaft |
Azolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
|
|
JP5213229B2
(ja)
|
2004-04-23 |
2013-06-19 |
エグゼリクシス， インコーポレイテッド |
キナーゼ調節因子および使用方法
|
|
WO2005123672A2
(en)
|
2004-06-14 |
2005-12-29 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
|
BRPI0513899A
(pt)
|
2004-07-27 |
2008-05-20 |
Sgx Pharmaceuticals Inc |
moduladores de cinase heterocìclica de anel fundido
|
|
US7626021B2
(en)
|
2004-07-27 |
2009-12-01 |
Sgx Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
|
EP1812440B1
(en)
|
2004-11-04 |
2010-09-22 |
Vertex Pharmaceuticals, Inc. |
Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
|
|
US8003806B2
(en)
|
2004-11-12 |
2011-08-23 |
OSI Pharmaceuticals, LLC |
Integrin antagonists useful as anticancer agents
|
|
EP1814883A1
(en)
|
2004-11-22 |
2007-08-08 |
Vertex Pharmaceuticals Incorporated |
Bicyclic inhibitors or rho kinase
|
|
GB0428235D0
(en)
|
2004-12-23 |
2005-01-26 |
Glaxo Group Ltd |
Novel compounds
|
|
ATE519488T1
(de)
|
2004-12-27 |
2011-08-15 |
Novartis Ag |
Aminopyrazin-analoga zur behandlung von glaukomen und anderen durch rho-kinase verursachten krankheiten
|
|
US7635699B2
(en)
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
GB0500492D0
(en)
|
2005-01-11 |
2005-02-16 |
Cyclacel Ltd |
Compound
|
|
US7622583B2
(en)
|
2005-01-14 |
2009-11-24 |
Chemocentryx, Inc. |
Heteroaryl sulfonamides and CCR2
|
|
US20060156482A1
(en)
|
2005-01-14 |
2006-07-20 |
The Procter & Gamble Company |
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
|
|
GB0501999D0
(en)
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
WO2006088837A2
(en)
|
2005-02-16 |
2006-08-24 |
Schering Corporation |
Heterocyclic substituted piperazines with cxcr3 antagonist activity
|
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
WO2006114180A1
(de)
|
2005-04-25 |
2006-11-02 |
Merck Patent Gmbh |
Neuartige aza-heterozyklen als kinase-inhibitoren
|
|
EA013525B1
(ru)
|
2005-05-20 |
2010-06-30 |
Алантос-Фармасьютикалз Холдинг, Инк. |
Гетеробициклические ингибиторы металлопротеазы и их применение
|
|
US20070155737A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
|
US20070155738A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
|
WO2007015632A1
(en)
|
2005-08-04 |
2007-02-08 |
Cgk Co., Ltd. |
Atm and atr inhibitor
|
|
US7776865B2
(en)
|
2005-10-06 |
2010-08-17 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
CN101360499B
(zh)
|
2005-10-06 |
2015-10-07 |
默沙东公司 |
吡唑并[1,5-a]嘧啶衍生物在制备抑制蛋白激酶的药物中的用途
|
|
AR057979A1
(es)
|
2005-10-06 |
2008-01-09 |
Schering Corp |
PIRAZOLPIRIMIDINAS COMO INHIBIDORAS DE PROTEíNA QUINASA. COMPOSICIONES FARMACEUTICAS.
|
|
WO2007044426A2
(en)
|
2005-10-06 |
2007-04-19 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
|
JP5119157B2
(ja)
|
2005-10-21 |
2013-01-16 |
エクセリクシス， インク． |
カゼインキナーゼｉｉ（ｃｋ２）モジュレーターとしてのピラゾロ−ピリミジン類
|
|
EP1945220A1
(en)
|
2005-10-21 |
2008-07-23 |
Mitsubishi Tanabe Pharma Corporation |
Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists
|
|
TW200736260A
(en)
|
2005-11-10 |
2007-10-01 |
Smithkline Beecham Corp |
Inhibitors of Akt activity
|
|
CN101321525B
(zh)
|
2005-12-01 |
2013-01-30 |
霍夫曼-拉罗奇有限公司 |
作为l-cpt1抑制剂的杂芳基取代的哌啶衍生物
|
|
EP1970377A4
(en)
|
2005-12-09 |
2013-02-27 |
Meiji Seika Kaisha |
LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THIS AS AN ACTIVE SUBSTANCE
|
|
BRPI0620463A2
(pt)
|
2005-12-22 |
2011-11-16 |
Alcon Res Ltd |
composição farmacêutica oftálmica, compostos, e seus usos
|
|
ITMI20060311A1
(it)
|
2006-02-21 |
2007-08-22 |
Btsr Int Spa |
Dispositivo perfezionato di alimentazione di filo o filatio ad una macchina tessile e metodo per attuare tale alimentazione
|
|
GB0603684D0
(en)
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
|
WO2007096764A2
(en)
|
2006-02-27 |
2007-08-30 |
Glenmark Pharmaceuticals S.A. |
Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
|
|
TW200800203A
(en)
|
2006-03-08 |
2008-01-01 |
Astrazeneca Ab |
New use
|
|
RU2008141761A
(ru)
|
2006-03-22 |
2010-04-27 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
ИНГИБИТОРЫ с-МЕТ ПРОТЕИНКИНАЗЫ
|
|
JP2009531443A
(ja)
|
2006-03-29 |
2009-09-03 |
フォールドアールエックス ファーマシューティカルズ インコーポレーティッド |
α−シヌクレイン毒性の抑制
|
|
EP2001870A2
(en)
|
2006-03-31 |
2008-12-17 |
Schering Corporation |
Kinase inhibitors
|
|
KR20090019796A
(ko)
|
2006-05-22 |
2009-02-25 |
쉐링 코포레이션 |
ＣＤＫ 억제제로서의 피라졸로[1,5-ａ]피리미딘
|
|
JP2009541323A
(ja)
|
2006-06-22 |
2009-11-26 |
マリンクロット インコーポレイテッド |
拡張された共役を有するピラジン誘導体およびその使用
|
|
EP2044051B1
(en)
|
2006-06-22 |
2010-01-27 |
BIOVITRUM AB (publ) |
Pyridine and pyrazine derivatives as mnk kinase inhibitors
|
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
RU2009115954A
(ru)
|
2006-09-29 |
2010-11-10 |
Новартис АГ (CH) |
Пиразолопиримидины в качестве ингибиторов липидной киназы р13к
|
|
GB0619342D0
(en)
|
2006-09-30 |
2006-11-08 |
Vernalis R&D Ltd |
New chemical compounds
|
|
BRPI0717845A2
(pt)
|
2006-10-04 |
2015-06-16 |
Hoffmann La Roche |
Uso de compostos, composições farmacêuticas e métodos para o tratamento e/ou profilaxia de enfermidades que podem ser tratadas com agentes de elevação de colesterol-hdl e compostos
|
|
NZ576278A
(en)
|
2006-10-19 |
2011-12-22 |
Signal Pharm Llc |
Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
|
|
EP2081928B1
(en)
|
2006-11-10 |
2014-02-26 |
Bristol-Myers Squibb Company |
Pyrrolo-pyridine kinase inhibitors
|
|
CA2670083A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic metalloprotease inhibitors
|
|
KR20090088962A
(ko)
|
2006-12-15 |
2009-08-20 |
바이엘 쉐링 파마 악티엔게젤샤프트 |
３-ｈ-피라졸로피리딘 및 그의 염, 이를 포함하는 제약 조성물, 이의 제조 방법 및 이의 용도
|
|
EP2125781A2
(en)
|
2006-12-20 |
2009-12-02 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
|
PE20081581A1
(es)
|
2006-12-21 |
2008-11-12 |
Plexxikon Inc |
COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
|
|
GB0625659D0
(en)
|
2006-12-21 |
2007-01-31 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
|
CA2676173A1
(en)
|
2007-02-16 |
2008-08-28 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
|
|
ES2431163T3
(es)
|
2007-03-01 |
2013-11-25 |
Novartis Ag |
Inhibidores de PIM quinasa y métodos para su uso
|
|
KR20090130064A
(ko)
|
2007-04-10 |
2009-12-17 |
바이엘 크롭사이언스 아게 |
살충성 아릴 이속사졸린 유도체
|
|
US7592342B2
(en)
|
2007-05-10 |
2009-09-22 |
Smithkline Beecham Corporation |
Quinoxaline derivatives as PI3 kinase inhibitors
|
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
EP2014661A1
(de)
|
2007-06-13 |
2009-01-14 |
Bayer CropScience AG |
Heterocyclisch substituierte Heterocyclyl-carbonsäurederivate
|
|
UY31137A1
(es)
|
2007-06-14 |
2009-01-05 |
Smithkline Beecham Corp |
Derivados de quinazolina como inhibidores de la pi3 quinasa
|
|
WO2008156174A1
(ja)
|
2007-06-21 |
2008-12-24 |
Taisho Pharmaceutical Co., Ltd. |
ピラジンアミド化合物
|
|
CA2691003A1
(en)
|
2007-06-26 |
2008-12-31 |
Lexicon Pharmaceuticals, Inc. |
Methods of treating serotonin-mediated diseases and disorders
|
|
US20090012103A1
(en)
|
2007-07-05 |
2009-01-08 |
Matthew Abelman |
Substituted heterocyclic compounds
|
|
WO2009006580A1
(en)
|
2007-07-05 |
2009-01-08 |
Cv Therapeutics, Inc. |
Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
|
|
GB0713259D0
(en)
|
2007-07-09 |
2007-08-15 |
Astrazeneca Ab |
Pyrazine derivatives 954
|
|
SG187396A1
(en)
|
2007-07-19 |
2013-02-28 |
Lundbeck & Co As H |
5-membered heterocyclic amides and related compounds
|
|
US8293747B2
(en)
|
2007-07-19 |
2012-10-23 |
Merck Sharp & Dohme Corp. |
Heterocyclic amide compounds as protein kinase inhibitors
|
|
CN101815712A
(zh)
|
2007-08-01 |
2010-08-25 |
辉瑞有限公司 |
吡唑化合物及其作为raf抑制剂的用途
|
|
WO2009017954A1
(en)
|
2007-08-01 |
2009-02-05 |
Phenomix Corporation |
Inhibitors of jak2 kinase
|
|
WO2009024825A1
(en)
|
2007-08-21 |
2009-02-26 |
Astrazeneca Ab |
2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors
|
|
US8415358B2
(en)
|
2007-09-17 |
2013-04-09 |
Neurosearch A/S |
Pyrazine derivatives and their use as potassium channel modulators
|
|
AU2008315746A1
(en)
|
2007-10-25 |
2009-04-30 |
Astrazeneca Ab |
Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders
|
|
WO2009070567A1
(en)
|
2007-11-28 |
2009-06-04 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
WO2009075790A1
(en)
|
2007-12-07 |
2009-06-18 |
Alantos Pharmaceuticals Holding, Inc. |
Metalloprotease inhibitors for intra-articular application
|
|
AU2009204483B2
(en)
|
2008-01-04 |
2014-03-13 |
Intellikine, Llc |
Certain chemical entities, compositions and methods
|
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
|
PT2250172E
(pt)
|
2008-02-25 |
2011-11-30 |
Hoffmann La Roche |
Inibidores de pirrolpirazina-cinase
|
|
MX2010008198A
(es)
|
2008-02-25 |
2010-08-23 |
Hoffmann La Roche |
Inhibidores de cinasa de pirrolopirazina.
|
|
ATE517107T1
(de)
|
2008-02-25 |
2011-08-15 |
Hoffmann La Roche |
Pyrrolopyrazinkinaseinhibitoren
|
|
CA2713718A1
(en)
|
2008-02-25 |
2009-09-03 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine kinase inhibitors
|
|
TW200940537A
(en)
|
2008-02-26 |
2009-10-01 |
Astrazeneca Ab |
Heterocyclic urea derivatives and methods of use thereof
|
|
WO2009117157A1
(en)
|
2008-03-20 |
2009-09-24 |
Amgen Inc. |
Aurora kinase modulators and method of use
|
|
WO2009152087A1
(en)
|
2008-06-10 |
2009-12-17 |
Plexxikon, Inc. |
Bicyclic heteroaryl compounds and methods for kinase modulation, and indications therefor
|
|
MX2011000216A
(es)
|
2008-07-08 |
2011-03-29 |
Intellikine Inc |
Inhibidores de cinasa y metodos para su uso.
|
|
WO2010017047A1
(en)
|
2008-08-05 |
2010-02-11 |
Merck & Co., Inc. |
Therapeutic compounds
|
|
GB0814364D0
(en)
|
2008-08-05 |
2008-09-10 |
Eisai London Res Lab Ltd |
Diazaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase
|
|
CN102223798A
(zh)
|
2008-09-24 |
2011-10-19 |
巴斯夫欧洲公司 |
用于防治无脊椎动物害虫的吡唑化合物
|
|
MX2011004188A
(es)
|
2008-10-21 |
2011-06-09 |
Vertex Pharma |
Inhibidores de la proteina cinasa c-met.
|
|
RU2539568C2
(ru)
|
2008-10-31 |
2015-01-20 |
Дженентек, Инк. |
Пиразолопиримидиновые соединения-ингибиторы jak и способы
|
|
MX2011004953A
(es)
|
2008-11-10 |
2011-12-14 |
Vertex Pharma |
Compuestos utiles como inhibidores de cinasa atr.
|
|
WO2010059836A1
(en)
|
2008-11-20 |
2010-05-27 |
Decode Genetics Ehf |
Substituted aza-bridged bicyclics for cardiovascular and cns disease
|
|
CN102264743B
(zh)
|
2008-11-25 |
2015-02-11 |
罗彻斯特大学 |
Mlk抑制剂及其使用方法
|
|
JP5431495B2
(ja)
|
2008-12-05 |
2014-03-05 |
エフ．ホフマン−ラ ロシュ アーゲー |
ピロロピラジニル尿素キナーゼ阻害薬
|
|
ES2921576T3
(es)
|
2008-12-19 |
2022-08-29 |
Vertex Pharma |
Compuestos útiles como inhibidores de la quinasa ATR
|
|
CN102264737A
(zh)
|
2008-12-23 |
2011-11-30 |
雅培制药有限公司 |
抗病毒化合物
|
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
|
SG173027A1
(en)
|
2009-01-30 |
2011-08-29 |
Toyama Chemical Co Ltd |
N-acyl anthranilic acid derivative or salt thereof
|
|
US20100204265A1
(en)
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
|
WO2010093425A1
(en)
|
2009-02-11 |
2010-08-19 |
Sepracor Inc. |
Histamine h3 inverse agonists and antagonists and methods of use thereof
|
|
CN101537007A
(zh)
|
2009-03-18 |
2009-09-23 |
中国医学科学院血液病医院（血液学研究所） |
N-(噻吩-2)吡唑并[1,5-a]嘧啶-3-甲酰胺类化合物在制备抗恶性肿瘤药物方面的应用
|
|
JP2012522013A
(ja)
|
2009-03-27 |
2012-09-20 |
ザ ユーエービー リサーチ ファウンデーション |
調節ｉｒｅｓ媒介翻訳
|
|
UA110324C2
(en)
*
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
ES2483594T3
(es)
|
2009-07-15 |
2014-08-06 |
Abbott Laboratories |
Pirrolopirazinas inhibidoras de quinasas
|
|
GEP201706639B
(en)
|
2009-08-17 |
2017-03-27 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
WO2011025706A2
(en)
|
2009-08-26 |
2011-03-03 |
Schering Corporation |
Heterocyclic amide compounds as protein kinase inhibitors
|
|
CN101671336B
(zh)
|
2009-09-23 |
2013-11-13 |
辽宁利锋科技开发有限公司 |
芳杂环并嘧啶衍生物和类似物及其制备方法和用途
|
|
KR101851130B1
(ko)
|
2009-12-04 |
2018-04-23 |
센화 바이오사이언시즈 인코포레이티드 |
Ｃｋ2 억제제로서 피라졸로피리미딘 및 관련된 헤테로사이클
|
|
ES2572387T3
(es)
|
2010-03-18 |
2016-05-31 |
Pasteur Institut Korea |
Compuestos anti-infecciosos
|
|
US8518945B2
(en)
|
2010-03-22 |
2013-08-27 |
Hoffmann-La Roche Inc. |
Pyrrolopyrazine kinase inhibitors
|
|
WO2011121096A1
(en)
|
2010-03-31 |
2011-10-06 |
Dkfz Deutsches Krebsforschungszentrum |
PYRAZOL[1,5-a]PYRIMIDINE DERIVATIVES AS WNT PATHWAY ANTAGONISTS
|
|
CA2794428A1
(en)
|
2010-04-08 |
2011-10-13 |
Pfizer Inc. |
Substituted 3,5-diphenyl-isoxazoline derivatives as insecticides and acaricides
|
|
EP2558866B1
(en)
|
2010-04-15 |
2016-08-17 |
Tracon Pharmaceuticals, Inc. |
Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
|
|
US8969356B2
(en)
|
2010-05-12 |
2015-03-03 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2569286B1
(en)
|
2010-05-12 |
2014-08-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
US9334244B2
(en)
|
2010-05-12 |
2016-05-10 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2569313A1
(en)
|
2010-05-12 |
2013-03-20 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
NZ603478A
(en)
|
2010-05-12 |
2014-09-26 |
Vertex Pharma |
2 -aminopyridine derivatives useful as inhibitors of atr kinase
|
|
WO2011143419A1
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazines useful as inhibitors of atr kinase
|
|
KR20130083387A
(ko)
|
2010-05-20 |
2013-07-22 |
에프. 호프만-라 로슈 아게 |
Syk 및 jak 억제제로서 피롤로피라진 유도체
|
|
KR20130083386A
(ko)
|
2010-05-20 |
2013-07-22 |
에프. 호프만-라 로슈 아게 |
피롤로[2,3-ｂ]피라진-7-카복스아마이드 유도체 및 ＪＡＫ 및 ＳＹＫ 억제제로서의 그의 용도
|
|
EP2585468A1
(en)
|
2010-06-23 |
2013-05-01 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
|
|
RS54761B1
(sr)
|
2010-06-24 |
2016-10-31 |
Gilead Sciences |
Pirazolo[1,5-a]pirimidini i-triazini kao antiviralni agensi
|
|
CN102311396B
(zh)
|
2010-07-05 |
2015-01-07 |
暨南大学 |
一种吡嗪类衍生物和其制备方法及在制药中的应用
|
|
KR101995013B1
(ko)
|
2010-07-13 |
2019-07-02 |
에프. 호프만-라 로슈 아게 |
Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체
|
|
EP2407478A1
(en)
|
2010-07-14 |
2012-01-18 |
GENETADI Biotech, S.L. |
New cyclotetrapeptides with pro-angiogenic properties
|
|
WO2012022045A1
(en)
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
|
CA2817968C
(en)
|
2010-11-16 |
2019-03-12 |
Array Biopharma Inc. |
Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors
|
|
US8609669B2
(en)
|
2010-11-16 |
2013-12-17 |
Abbvie Inc. |
Potassium channel modulators
|
|
EP2649075B1
(en)
|
2010-12-08 |
2018-04-25 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Substituted pyrazolopyrimidines as glucocerebrosidase activators
|
|
CA2825098C
(en)
|
2011-01-27 |
2020-03-10 |
Universite De Montreal |
Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
|
|
AU2012240030A1
(en)
|
2011-04-05 |
2013-10-24 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of TRA kinase
|
|
ES2583086T3
(es)
|
2011-04-21 |
2016-09-19 |
Bayer Intellectual Property Gmbh |
Pirazolopiridinas sustituidas con fluoroalquilo y su uso
|
|
KR102104125B1
(ko)
|
2011-04-21 |
2020-05-29 |
재단법인 한국파스퇴르연구소 |
소염 화합물
|
|
AU2012255792A1
(en)
|
2011-05-17 |
2013-11-07 |
Principia Biopharma Inc. |
Azaindole derivatives as tyrosine kinase inhibitors
|
|
US9309250B2
(en)
|
2011-06-22 |
2016-04-12 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
|
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CN103764166B
(zh)
|
2011-06-22 |
2017-10-24 |
通用医疗公司 |
蛋白质病的治疗
|
|
EP2723747A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
BR112014000653A2
(pt)
|
2011-07-13 |
2017-02-14 |
Pharmacyclics Inc |
inibidores de tirosina quinase de bruton
|
|
WO2013052263A2
(en)
|
2011-09-16 |
2013-04-11 |
Microbiotix, Inc. |
Antifungal compounds
|
|
WO2013049720A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CA2850564A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8765751B2
(en)
|
2011-09-30 |
2014-07-01 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP3878851A1
(en)
|
2011-09-30 |
2021-09-15 |
Vertex Pharmaceuticals Incorporated |
Process for making compounds useful as inhibitors of atr kinase
|
|
RU2018108589A
(ru)
|
2011-09-30 |
2019-02-25 |
Вертекс Фармасьютикалз Инкорпорейтед |
Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr
|
|
EP2768509B1
(en)
|
2011-10-20 |
2017-03-22 |
Glaxosmithkline LLC |
Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
|
|
WO2013071090A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8846917B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2776429A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
EP2776420A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
|
JP2015502925A
(ja)
|
2011-11-09 |
2015-01-29 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
Ａｔｒキナーゼの阻害剤として有用なピラジン化合物
|
|
WO2013138436A1
(en)
|
2012-03-14 |
2013-09-19 |
Bristol-Myers Squibb Company |
Cyclolic hydrazine derivatives as hiv attachment inhibitors
|
|
AR090548A1
(es)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
|
|
AU2013243671B2
(en)
|
2012-04-02 |
2017-09-21 |
Cytokinetics, Inc. |
Methods for improving diaphragm function
|
|
PT2833973T
(pt)
|
2012-04-05 |
2017-12-21 |
Vertex Pharma |
Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos
|
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
CN103373996A
(zh)
|
2012-04-20 |
2013-10-30 |
山东亨利医药科技有限责任公司 |
作为crth2受体拮抗剂的二并环衍生物
|
|
KR20210156333A
(ko)
|
2012-05-15 |
2021-12-24 |
캔써 리서치 테크놀로지 리미티드 |
5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도
|
|
CN104334563B
(zh)
|
2012-05-23 |
2017-03-08 |
萨维拉制药有限公司 |
7‑氧代‑噻唑并吡啶碳酸衍生物和它们在治疗、改善或预防病毒疾病中的用途
|
|
HK1204987A1
(en)
|
2012-05-23 |
2015-12-11 |
Savira Pharmaceuticals Gmbh |
7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a]pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease
|
|
US20140018361A1
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
JP2014022472A
(ja)
*
|
2012-07-13 |
2014-02-03 |
Sharp Corp |
発光装置、照明装置および発光方法
|
|
WO2014015523A1
(en)
|
2012-07-27 |
2014-01-30 |
Hutchison Medipharma Limited |
Novel heteroaryl and heterocycle compounds, compositions and methods
|
|
CA2879245A1
(en)
|
2012-08-06 |
2014-02-13 |
Savira Pharmaceuticals Gmbh |
Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
|
|
US9505752B2
(en)
|
2012-08-09 |
2016-11-29 |
Viiv Healthcare Uk (No. 5) Limited |
Piperidine amide derivatives as HIV attachment inhibitors
|
|
WO2014025852A1
(en)
|
2012-08-09 |
2014-02-13 |
Bristol-Myers Squibb Company |
Tricyclic alkene derivatives as hiv attachment inhibitors
|
|
WO2014025850A1
(en)
|
2012-08-09 |
2014-02-13 |
Bristol-Myers Squibb Company |
Tricyclic amidine derivatives as hiv attachment inhibitors
|
|
KR20150044895A
(ko)
|
2012-08-17 |
2015-04-27 |
바이엘 크롭사이언스 아게 |
살곤충제 및 살응애제로서의 아자인돌 카르복실산 아미드 및 아자인돌 티오카르복실산 아미드
|
|
MX2015001099A
(es)
|
2012-08-24 |
2015-04-08 |
Hoffmann La Roche |
Nuevos derivados biciclicos de piridina.
|
|
WO2014035140A2
(en)
|
2012-08-30 |
2014-03-06 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating histone methyltransferase activity
|
|
WO2014039831A1
(en)
|
2012-09-07 |
2014-03-13 |
Takeda Pharmaceutical Company Limited |
SUBSTITUTED-1,4-DIHYDROPYRAZOLO[4,3-b]INDOLES
|
|
WO2014042433A2
(en)
|
2012-09-14 |
2014-03-20 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating adenosine a3 receptor activity
|
|
TW201412740A
(zh)
|
2012-09-20 |
2014-04-01 |
Bayer Pharma AG |
經取代之吡咯并嘧啶胺基苯并噻唑酮
|
|
CN104812389B
(zh)
|
2012-09-24 |
2020-07-17 |
润新生物公司 |
某些化学实体、组合物及方法
|
|
WO2014055756A1
(en)
|
2012-10-04 |
2014-04-10 |
Vertex Pharmaceuticals Incorporated |
Method for measuring atr inhibition mediated increases in dna damage
|
|
CA2900335C
(en)
|
2012-10-22 |
2021-10-26 |
City Of Hope |
Synthetic analogs of epipolythiodioxopiperazines and uses thereof
|
|
US9012643B2
(en)
|
2012-10-24 |
2015-04-21 |
Becton, Dickinson And Company |
Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same
|
|
WO2014089379A1
(en)
|
2012-12-07 |
2014-06-12 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
EP2970288A1
(en)
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US9663519B2
(en)
|
2013-03-15 |
2017-05-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2970289A1
(en)
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
US20150158868A1
(en)
|
2013-12-06 |
2015-06-11 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2015085132A1
(en)
|
2013-12-06 |
2015-06-11 |
Vertex Pharmaceuticals Incorporated |
2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
|
|
HRP20200186T1
(hr)
|
2014-06-05 |
2020-05-29 |
Vertex Pharmaceuticals Inc. |
Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici
|
|
JP6936007B2
(ja)
|
2014-06-17 |
2021-09-15 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
Ｃｈｋ１阻害剤とａｔｒ阻害剤との組み合わせを使用してがんを処置する方法
|