JP2013049690A5 - - Google Patents
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- Publication number
- JP2013049690A5 JP2013049690A5 JP2012235328A JP2012235328A JP2013049690A5 JP 2013049690 A5 JP2013049690 A5 JP 2013049690A5 JP 2012235328 A JP2012235328 A JP 2012235328A JP 2012235328 A JP2012235328 A JP 2012235328A JP 2013049690 A5 JP2013049690 A5 JP 2013049690A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- ethanol
- solvent
- compound
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0613692A GB0613692D0 (en) | 2006-07-10 | 2006-07-10 | Benzodiazepine salts |
| GB0613694.9 | 2006-07-10 | ||
| GB0613692.3 | 2006-07-10 | ||
| GB0613694A GB0613694D0 (en) | 2006-07-10 | 2006-07-10 | Benzodiazepine salts |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518952A Division JP5433413B2 (ja) | 2006-07-10 | 2007-07-10 | 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013049690A JP2013049690A (ja) | 2013-03-14 |
| JP2013049690A5 true JP2013049690A5 (enExample) | 2013-09-05 |
| JP5785923B2 JP5785923B2 (ja) | 2015-09-30 |
Family
ID=38535381
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518952A Active JP5433413B2 (ja) | 2006-07-10 | 2007-07-10 | 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態 |
| JP2012235328A Active JP5785923B2 (ja) | 2006-07-10 | 2012-10-25 | 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518952A Active JP5433413B2 (ja) | 2006-07-10 | 2007-07-10 | 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US9193730B2 (enExample) |
| EP (1) | EP2081921B1 (enExample) |
| JP (2) | JP5433413B2 (enExample) |
| KR (3) | KR20170091770A (enExample) |
| CN (3) | CN104059072B (enExample) |
| AT (1) | ATE480532T1 (enExample) |
| AU (1) | AU2007274054B2 (enExample) |
| BR (1) | BRPI0714886B8 (enExample) |
| CA (1) | CA2657347C (enExample) |
| DE (1) | DE602007009128D1 (enExample) |
| DK (1) | DK2081921T3 (enExample) |
| MX (1) | MX2009000404A (enExample) |
| PL (1) | PL2081921T3 (enExample) |
| PT (1) | PT2081921E (enExample) |
| RU (1) | RU2470935C2 (enExample) |
| SI (1) | SI2081921T1 (enExample) |
| WO (1) | WO2008007071A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2081921T1 (sl) | 2006-07-10 | 2011-01-31 | Paion Uk Ltd | Soli benzodiazepina s kratkotrajnim učinkom ter njihove polimorfne oblike |
| GB0613693D0 (en) | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| EP2305647A1 (en) | 2009-09-18 | 2011-04-06 | PAION UK Limited | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| PE20150683A1 (es) * | 2012-05-22 | 2015-06-03 | Paion Uk Ltd | Composiciones que comprenden benzodiazepinas de accion corta |
| SG11201501358SA (en) * | 2012-08-31 | 2015-04-29 | Paion Uk Ltd | Method for administering hypnotic/sedative agent |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| US9994578B2 (en) | 2014-07-23 | 2018-06-12 | Jiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd | Benzodiazepine derivative and use thereof |
| US20170081954A1 (en) * | 2015-09-23 | 2017-03-23 | Tesco Corporation | Pipe joint location detection system and method |
| CN107266452A (zh) * | 2016-04-08 | 2017-10-20 | 四川科伦药物研究院有限公司 | 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途 |
| KR20180131617A (ko) * | 2016-04-14 | 2018-12-10 | 파이온 유케이 리미티드 | 경구 흡입 및 비 벤조디아제핀 |
| CN108503644B (zh) * | 2016-12-09 | 2019-06-14 | 成都倍特药业有限公司 | 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途 |
| ES2916845T3 (es) | 2017-02-09 | 2022-07-06 | Assia Chem Ind Ltd | Proceso para la preparación de remimazolam y formas en estado sólido de sales de remimazolam |
| CN108948018B (zh) * | 2017-05-17 | 2021-03-30 | 四川科伦博泰生物医药股份有限公司 | 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途 |
| WO2019158075A1 (zh) | 2018-02-13 | 2019-08-22 | 江苏恩华络康药物研发有限公司 | 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用 |
| CN110398514B (zh) * | 2018-04-24 | 2023-04-28 | 恒天纤维集团有限公司 | 一种快速判断纤维素胶液中金属杂质含量的方法 |
| ES2803099B2 (es) | 2019-07-22 | 2021-11-08 | Moehs Iberica Sl | Procedimiento de obtención de besilato de remimazolam amorfo |
| CN114478535B (zh) * | 2020-10-23 | 2024-02-09 | 成都苑东生物制药股份有限公司 | 一种苯磺酸瑞马唑仑ii晶型的制备方法 |
| WO2023037237A1 (en) * | 2021-09-09 | 2023-03-16 | Wavelength Enterprises Ltd | Process for the preparation of remimazolam |
| US20250263414A1 (en) | 2022-04-08 | 2025-08-21 | Fresenius Kabi Oncology Limited | An improved process for the preparation of remimazolam |
| CN115448927A (zh) * | 2022-10-20 | 2022-12-09 | 重庆瑞泊莱医药科技有限公司 | 一种氢溴酸依匹斯汀晶型ii及其制备方法 |
| WO2025052259A1 (en) | 2023-09-05 | 2025-03-13 | Reena Patel | Ready to use compositions of remimazolam |
Family Cites Families (69)
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|---|---|---|---|---|
| US3520877A (en) | 1967-10-02 | 1970-07-21 | Hoffmann La Roche | 3-carbonyl amino acetic acid ethyl ester substituted benzodiazepines |
| BR6915069D0 (pt) | 1969-02-28 | 1973-08-16 | Upjohn Co | Compostos organicos e processo |
| DK124481B (da) | 1969-09-01 | 1972-10-23 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater samt deres 4-N-oxyder og salte. |
| DE2156472A1 (de) | 1970-11-23 | 1972-05-31 | Ciba-Geigy Ag, Basel (Schweiz) | Verfahren zur Herstellung von neuen Diazepinderivaten |
| US3933794A (en) * | 1971-08-04 | 1976-01-20 | The Upjohn Company | 2-(2-Alkynylamino)-3H-1,4-benzodiazepines |
| FR2183716A1 (en) | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| IE41197B1 (en) | 1973-05-29 | 1979-11-07 | Squibb & Sons Inc | 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones |
| CH608234A5 (en) | 1974-08-30 | 1978-12-29 | Crc Ricerca Chim | Process for the preparation of lithium salts of 1,4-benzodiazepines |
| DE2900017A1 (de) | 1978-01-10 | 1979-07-12 | Clin Midy | 3-alkoxycarbonyl-benzodiazepin- derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| MC1528A1 (fr) | 1982-07-21 | 1984-04-13 | Hoffmann La Roche | Imidazobenzodiazepines |
| IT1165588B (it) | 1983-03-23 | 1987-04-22 | Medosan Ind Biochimi | 1,4 benzodiazepine terapeuticamente attive |
| US4755508A (en) | 1984-06-26 | 1988-07-05 | Merck & Co., Inc. | Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin |
| US4820834A (en) | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| US4724237A (en) | 1984-06-26 | 1988-02-09 | Merck & Co., Inc. | 2-substituted-aminomethyl-1,4-benzodiazepines |
| CA1332410C (en) | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
| DE3435973A1 (de) | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| ATE132974T1 (de) | 1986-10-24 | 1996-01-15 | Abbott Lab | Test, indikatoren, immunogene und antikörper für benzodiazepine |
| DE68908527T2 (de) | 1988-04-29 | 1993-12-16 | Baker Norton Pharma | Verfahren zur sicheren anästhesie oder bewusstseinssedierung. |
| US5019583A (en) * | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| DE69017302T3 (de) | 1989-08-04 | 1999-08-05 | Merck Sharp & Dohme Ltd., Hoddesdon, Hertfordshire | Zentrale Cholecystokinin-Antagonisten zur Behandlung von psychiatrischen Krankheiten. |
| DE69026708T2 (de) | 1989-10-20 | 1997-04-03 | Otsuka Pharma Co Ltd | Benzoheterozyklische verbindungen |
| CA2032427A1 (en) | 1989-12-18 | 1991-06-19 | Mark G. Bock | Benzodiazepines analogs |
| US5324726A (en) | 1989-12-18 | 1994-06-28 | Merck & Co., Inc. | Benzodiazepine analogs |
| IL96613A0 (en) | 1989-12-18 | 1991-09-16 | Merck & Co Inc | Pharmaceutical compositions containing benzodiazepine analogs |
| US5220017A (en) | 1991-04-10 | 1993-06-15 | Merck & Co., Inc. | Cholecystokinin antagonists |
| US5185331A (en) | 1991-05-14 | 1993-02-09 | Merck & Co., Inc. | Triazolobenzodiazepines |
| CA2071181A1 (en) | 1991-06-14 | 1992-12-15 | Roger M. Freidinger | Benzodiazepine analogs |
| GB9117852D0 (en) | 1991-08-19 | 1991-10-09 | Merck Sharp & Dohme | Therapeutic agents |
| CA2120939A1 (en) | 1991-10-11 | 1993-04-15 | Tetsuya Tahara | Therapeutic agent for osteoporosis and diazepine compound |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| CA2143246C (en) * | 1994-03-16 | 2000-08-22 | Thierry Godel | Imidazodiazepines |
| US5834464A (en) * | 1994-11-18 | 1998-11-10 | Merck & Co., Inc. | Imidazolinobenzodiazepines |
| FI972865L (fi) | 1995-01-06 | 1997-09-03 | Hoffmann La Roche | Hydroksimetyyli-imidatsodiatseptiinejä ja niiden esterit |
| AU4382896A (en) | 1995-02-02 | 1996-08-21 | F. Hoffmann-La Roche Ag | Acetylimidazobenzodiazepines |
| UA57734C2 (uk) | 1996-05-07 | 2003-07-15 | Пфайзер Інк. | Комплекси включення арилгетероциклічних солей |
| EP0907644A4 (en) | 1996-06-28 | 2003-02-05 | Merck & Co Inc | PHARMACEUTICAL PREPARATION |
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| EP0881235A1 (fr) | 1997-05-26 | 1998-12-02 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles |
| US6440959B1 (en) | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
| GB9911152D0 (en) * | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| US7806886B2 (en) | 1999-06-03 | 2010-10-05 | Medtronic Minimed, Inc. | Apparatus and method for controlling insulin infusion with state variable feedback |
| EP1161949A1 (en) | 2000-06-09 | 2001-12-12 | Warner-Lambert Company | Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease |
| CN101838218A (zh) | 2002-02-28 | 2010-09-22 | 日本烟草产业株式会社 | 酯化合物及其医药用途 |
| HU226410B1 (en) | 2003-04-22 | 2008-11-28 | Egis Gyogyszergyar Nyilvanosan | Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them |
| EP2417980A1 (en) | 2004-02-11 | 2012-02-15 | Amylin Pharmaceuticals Inc. | Hybrid polypeptides with selectable properties |
| US7687736B2 (en) | 2004-04-29 | 2010-03-30 | Smart Technologies Ulc | Tensioned touch panel and method of making same |
| SI21850A (sl) * | 2004-07-28 | 2006-02-28 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Soli olanzapina in njihova pretvorba v prosto bazo olanzapina |
| AU2005295729B2 (en) | 2004-10-13 | 2011-07-14 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| DE602006014097D1 (de) | 2005-01-18 | 2010-06-17 | Merck Sharp & Dohme | Cgrp-rezeptorantagonisten |
| WO2006088894A2 (en) | 2005-02-15 | 2006-08-24 | Elan Pharma International Limited | Aerosol and injectable formulations of nanoparticulate benzodiazepine |
| US20070040501A1 (en) | 2005-08-18 | 2007-02-22 | Aitken Bruce G | Method for inhibiting oxygen and moisture degradation of a device and the resulting device |
| GB0613693D0 (en) | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| GB0613692D0 (en) | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts |
| SI2081921T1 (sl) | 2006-07-10 | 2011-01-31 | Paion Uk Ltd | Soli benzodiazepina s kratkotrajnim učinkom ter njihove polimorfne oblike |
| CN101743238B (zh) | 2007-05-22 | 2014-04-30 | 凯莫森特里克斯股份有限公司 | 3-(咪唑基)-吡唑并[3,4-b]吡啶 |
| WO2009145323A1 (ja) | 2008-05-30 | 2009-12-03 | 日産化学工業株式会社 | 多環式化合物を用いるアルコールの酸化方法 |
| US20110294843A1 (en) | 2008-10-16 | 2011-12-01 | Paion Uk Limited | Administration scheme of polar opioid metabolites for post-operative pain management |
| US8865886B2 (en) | 2009-03-30 | 2014-10-21 | Nippon Paper Industries Co., Ltd. | Method for recovery/reuse of N-oxyl compound |
| EP2305647A1 (en) | 2009-09-18 | 2011-04-06 | PAION UK Limited | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
| EP3050885B1 (en) | 2009-11-05 | 2017-10-18 | GlaxoSmithKline LLC | Benzodiazepine bromodomain inhibitor |
| JP5635275B2 (ja) | 2010-01-28 | 2014-12-03 | 日清紡ホールディングス株式会社 | アルコールの酸化方法 |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| CN102964349A (zh) | 2011-08-31 | 2013-03-13 | 江苏恒瑞医药股份有限公司 | 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途 |
| JP5585597B2 (ja) | 2012-01-27 | 2014-09-10 | 株式会社デンソー | 車輪位置検出装置およびそれを備えたタイヤ空気圧検出装置 |
| PE20150683A1 (es) | 2012-05-22 | 2015-06-03 | Paion Uk Ltd | Composiciones que comprenden benzodiazepinas de accion corta |
| SG11201501358SA (en) | 2012-08-31 | 2015-04-29 | Paion Uk Ltd | Method for administering hypnotic/sedative agent |
| WO2014047903A1 (zh) | 2012-09-28 | 2014-04-03 | 华为技术有限公司 | 信道状态信息进程处理方法、网络设备和用户设备 |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
-
2007
- 2007-07-10 SI SI200730415T patent/SI2081921T1/sl unknown
- 2007-07-10 CN CN201410147318.2A patent/CN104059072B/zh active Active
- 2007-07-10 EP EP07733504A patent/EP2081921B1/en active Active
- 2007-07-10 AT AT07733504T patent/ATE480532T1/de active
- 2007-07-10 US US12/373,472 patent/US9193730B2/en active Active
- 2007-07-10 MX MX2009000404A patent/MX2009000404A/es active IP Right Grant
- 2007-07-10 RU RU2009104311/04A patent/RU2470935C2/ru active
- 2007-07-10 PL PL07733504T patent/PL2081921T3/pl unknown
- 2007-07-10 PT PT07733504T patent/PT2081921E/pt unknown
- 2007-07-10 KR KR1020177021356A patent/KR20170091770A/ko not_active Ceased
- 2007-07-10 KR KR1020097002747A patent/KR20090045233A/ko not_active Ceased
- 2007-07-10 WO PCT/GB2007/002565 patent/WO2008007071A1/en not_active Ceased
- 2007-07-10 CA CA2657347A patent/CA2657347C/en active Active
- 2007-07-10 CN CN201310166860.8A patent/CN103288834B/zh active Active
- 2007-07-10 DE DE602007009128T patent/DE602007009128D1/de active Active
- 2007-07-10 DK DK07733504.0T patent/DK2081921T3/da active
- 2007-07-10 JP JP2009518952A patent/JP5433413B2/ja active Active
- 2007-07-10 BR BRPI0714886A patent/BRPI0714886B8/pt active IP Right Grant
- 2007-07-10 AU AU2007274054A patent/AU2007274054B2/en active Active
- 2007-07-10 KR KR1020157016814A patent/KR20150081370A/ko not_active Ceased
- 2007-07-10 CN CN201410147078.6A patent/CN104059071B/zh active Active
-
2012
- 2012-10-25 JP JP2012235328A patent/JP5785923B2/ja active Active
-
2015
- 2015-11-23 US US14/948,889 patent/US9777007B2/en active Active
-
2017
- 2017-09-13 US US15/703,945 patent/US9914738B2/en active Active
-
2018
- 2018-02-28 US US15/908,081 patent/US10472365B2/en active Active
-
2019
- 2019-10-10 US US16/598,876 patent/US10961250B2/en active Active
-
2021
- 2021-02-18 US US17/178,346 patent/US12365684B2/en active Active
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