JP2013049690A5 - - Google Patents

Download PDF

Info

Publication number
JP2013049690A5
JP2013049690A5 JP2012235328A JP2012235328A JP2013049690A5 JP 2013049690 A5 JP2013049690 A5 JP 2013049690A5 JP 2012235328 A JP2012235328 A JP 2012235328A JP 2012235328 A JP2012235328 A JP 2012235328A JP 2013049690 A5 JP2013049690 A5 JP 2013049690A5
Authority
JP
Japan
Prior art keywords
mixture
ethanol
solvent
compound
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012235328A
Other languages
English (en)
Japanese (ja)
Other versions
JP5785923B2 (ja
JP2013049690A (ja
Filing date
Publication date
Priority claimed from GB0613694A external-priority patent/GB0613694D0/en
Priority claimed from GB0613692A external-priority patent/GB0613692D0/en
Application filed filed Critical
Publication of JP2013049690A publication Critical patent/JP2013049690A/ja
Publication of JP2013049690A5 publication Critical patent/JP2013049690A5/ja
Application granted granted Critical
Publication of JP5785923B2 publication Critical patent/JP5785923B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012235328A 2006-07-10 2012-10-25 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態 Active JP5785923B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0613694A GB0613694D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts
GB0613694.9 2006-07-10
GB0613692.3 2006-07-10
GB0613692A GB0613692D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2009518952A Division JP5433413B2 (ja) 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態

Publications (3)

Publication Number Publication Date
JP2013049690A JP2013049690A (ja) 2013-03-14
JP2013049690A5 true JP2013049690A5 (enExample) 2013-09-05
JP5785923B2 JP5785923B2 (ja) 2015-09-30

Family

ID=38535381

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009518952A Active JP5433413B2 (ja) 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態
JP2012235328A Active JP5785923B2 (ja) 2006-07-10 2012-10-25 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2009518952A Active JP5433413B2 (ja) 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびそれらの多形形態

Country Status (17)

Country Link
US (7) US9193730B2 (enExample)
EP (1) EP2081921B1 (enExample)
JP (2) JP5433413B2 (enExample)
KR (3) KR20090045233A (enExample)
CN (3) CN104059072B (enExample)
AT (1) ATE480532T1 (enExample)
AU (1) AU2007274054B2 (enExample)
BR (1) BRPI0714886B8 (enExample)
CA (1) CA2657347C (enExample)
DE (1) DE602007009128D1 (enExample)
DK (1) DK2081921T3 (enExample)
MX (1) MX2009000404A (enExample)
PL (1) PL2081921T3 (enExample)
PT (1) PT2081921E (enExample)
RU (1) RU2470935C2 (enExample)
SI (1) SI2081921T1 (enExample)
WO (1) WO2008007071A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
DE602007009128D1 (de) * 2006-07-10 2010-10-21 Paion Uk Ltd Benzodiazepinsalze mit kurzzeitwirkung und polymorphe formen davon
EP2305647A1 (en) * 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
GEAP201813666A (en) * 2012-05-22 2018-01-25 Paion Uk Ltd Compositions comprising short-acting benzodiazepines
SI2891494T1 (sl) * 2012-08-31 2023-12-29 Paion Uk Limited Postopek za dajanje hipnotika/pomirjevala
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
EP3162804B1 (en) 2014-07-23 2019-10-09 Jiangsu Nhwaluokang Pharmaceutical Research and Development Co., Ltd. New benzodiazepine derivative and use thereof
US20170081954A1 (en) * 2015-09-23 2017-03-23 Tesco Corporation Pipe joint location detection system and method
CN110511224A (zh) * 2016-04-08 2019-11-29 四川科伦药物研究院有限公司 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途
MX2018012498A (es) 2016-04-14 2019-07-01 Paion Uk Ltd Benzodiazepinas inhaladas y nasales oralmente.
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途
EP4086260A1 (en) 2017-02-09 2022-11-09 Assia Chemical Industries Ltd. Solid state forms of remimazolam salts
CN108948018B (zh) * 2017-05-17 2021-03-30 四川科伦博泰生物医药股份有限公司 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途
WO2019158075A1 (zh) 2018-02-13 2019-08-22 江苏恩华络康药物研发有限公司 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用
CN110398514B (zh) * 2018-04-24 2023-04-28 恒天纤维集团有限公司 一种快速判断纤维素胶液中金属杂质含量的方法
ES2803099B2 (es) 2019-07-22 2021-11-08 Moehs Iberica Sl Procedimiento de obtención de besilato de remimazolam amorfo
CN114478535B (zh) * 2020-10-23 2024-02-09 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法
WO2023037237A1 (en) * 2021-09-09 2023-03-16 Wavelength Enterprises Ltd Process for the preparation of remimazolam
EP4504731A1 (en) 2022-04-08 2025-02-12 Fresenius Kabi Oncology Ltd An improved process for the preparation of remimazolam
CN115448927A (zh) * 2022-10-20 2022-12-09 重庆瑞泊莱医药科技有限公司 一种氢溴酸依匹斯汀晶型ii及其制备方法
WO2025052259A1 (en) 2023-09-05 2025-03-13 Reena Patel Ready to use compositions of remimazolam

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3520877A (en) 1967-10-02 1970-07-21 Hoffmann La Roche 3-carbonyl amino acetic acid ethyl ester substituted benzodiazepines
BR6915069D0 (pt) 1969-02-28 1973-08-16 Upjohn Co Compostos organicos e processo
NL7012813A (enExample) 1969-09-01 1971-03-03
DE2156472A1 (de) 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
FR2183716A1 (en) 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
IE41197B1 (en) 1973-05-29 1979-11-07 Squibb & Sons Inc 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones
CH608234A5 (en) 1974-08-30 1978-12-29 Crc Ricerca Chim Process for the preparation of lithium salts of 1,4-benzodiazepines
DE2900017A1 (de) 1978-01-10 1979-07-12 Clin Midy 3-alkoxycarbonyl-benzodiazepin- derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
MC1528A1 (fr) 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
IT1165588B (it) 1983-03-23 1987-04-22 Medosan Ind Biochimi 1,4 benzodiazepine terapeuticamente attive
CA1332410C (en) 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4755508A (en) 1984-06-26 1988-07-05 Merck & Co., Inc. Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
US4820834A (en) 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4724237A (en) 1984-06-26 1988-02-09 Merck & Co., Inc. 2-substituted-aminomethyl-1,4-benzodiazepines
DE3435973A1 (de) 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
ES2084577T3 (es) 1986-10-24 1996-05-16 Abbott Lab Ensayo, trazadores, inmunogenos y anticuerpos para benzodiazepinas.
JP2620642B2 (ja) 1988-04-29 1997-06-18 ベーカー ノートン ファーマシューティカルズ インコーポレイテッド 麻薬性鎮痛剤とベンゾジアゼピンとを組み合わせて非経口投与した後に観察される平均血圧の低下を拮抗させるための医薬品
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
EP0411668B2 (en) 1989-08-04 1998-11-11 MERCK SHARP & DOHME LTD. Central cholecystokinin antagonists for treatment of psychiatric disorders
KR0167349B1 (ko) 1989-10-20 1999-02-18 오스카 아끼히꼬 벤조헤테로 고리 화합물
US5324726A (en) 1989-12-18 1994-06-28 Merck & Co., Inc. Benzodiazepine analogs
IL96613A0 (en) 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
IE904560A1 (en) 1989-12-18 1991-06-19 Merck & Co Inc New benzodiazepine analogs
US5220017A (en) 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
US5185331A (en) 1991-05-14 1993-02-09 Merck & Co., Inc. Triazolobenzodiazepines
EP0523845A3 (en) 1991-06-14 1993-11-18 Merck & Co Inc New benzodiazepine analogs
GB9117852D0 (en) 1991-08-19 1991-10-09 Merck Sharp & Dohme Therapeutic agents
US5593988A (en) 1991-10-11 1997-01-14 Yoshitomi Pharmaceutical Industries, Ltd. Therapeutic agent for osteoporosis and diazepine compound
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
CA2143246C (en) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
US5834464A (en) * 1994-11-18 1998-11-10 Merck & Co., Inc. Imidazolinobenzodiazepines
AU4296196A (en) 1995-01-06 1996-07-24 F. Hoffmann-La Roche Ag Hydroxymethylimidazodiazepines and their esters
AU4382896A (en) 1995-02-02 1996-08-21 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepines
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
CA2257948A1 (en) 1996-06-28 1998-01-08 Merck & Co., Inc. Antiarrhythmic combinations of selective iks antagonists with beta-adenergic blocking agents
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP0881235A1 (fr) 1997-05-26 1998-12-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles
US6440959B1 (en) 1999-04-21 2002-08-27 Hoffman-La Roche Inc. Pyrazolobenzodiazepines
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7806886B2 (en) 1999-06-03 2010-10-05 Medtronic Minimed, Inc. Apparatus and method for controlling insulin infusion with state variable feedback
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
CN101838218A (zh) 2002-02-28 2010-09-22 日本烟草产业株式会社 酯化合物及其医药用途
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
BRPI0507594A (pt) 2004-02-11 2007-07-03 Amylin Pharmaceuticals Inc polipetìdeos hìbridos com propriedades selecionáveis
US7687736B2 (en) 2004-04-29 2010-03-30 Smart Technologies Ulc Tensioned touch panel and method of making same
SI21850A (sl) 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
WO2006044504A1 (en) 2004-10-13 2006-04-27 Merck & Co., Inc. Cgrp receptor antagonists
WO2006078554A2 (en) 2005-01-18 2006-07-27 Merck & Co., Inc. Cgrp receptor antagonists
EA013433B1 (ru) 2005-02-15 2010-04-30 Элан Фарма Интернэшнл Лтд. Аэрозольные и впрыскиваемые рецептуры лекарственных препаратов бензодиазепина, состоящего из наночастиц
US20070040501A1 (en) 2005-08-18 2007-02-22 Aitken Bruce G Method for inhibiting oxygen and moisture degradation of a device and the resulting device
DE602007009128D1 (de) 2006-07-10 2010-10-21 Paion Uk Ltd Benzodiazepinsalze mit kurzzeitwirkung und polymorphe formen davon
GB0613692D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
EA015529B1 (ru) 2007-05-22 2011-08-30 Кемосентрикс, Инк. 3-(имидазолил)пиразоло[3,4-b]пиридины
WO2009145323A1 (ja) 2008-05-30 2009-12-03 日産化学工業株式会社 多環式化合物を用いるアルコールの酸化方法
US20110294843A1 (en) 2008-10-16 2011-12-01 Paion Uk Limited Administration scheme of polar opioid metabolites for post-operative pain management
CA2755338C (en) 2009-03-30 2017-01-10 Nippon Paper Industries Co., Ltd. Method for recovery/reuse of n-oxyl compound
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
KR20120097508A (ko) 2009-11-05 2012-09-04 글락소스미스클라인 엘엘씨 벤조디아제핀 브로모도메인 억제제
JP5635275B2 (ja) 2010-01-28 2014-12-03 日清紡ホールディングス株式会社 アルコールの酸化方法
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN102964349A (zh) 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
JP5585597B2 (ja) 2012-01-27 2014-09-10 株式会社デンソー 車輪位置検出装置およびそれを備えたタイヤ空気圧検出装置
GEAP201813666A (en) 2012-05-22 2018-01-25 Paion Uk Ltd Compositions comprising short-acting benzodiazepines
SI2891494T1 (sl) 2012-08-31 2023-12-29 Paion Uk Limited Postopek za dajanje hipnotika/pomirjevala
CA2887728C (en) 2012-09-28 2019-07-09 Huawei Technologies Co., Ltd. Channel-state information process processing method, network device, and user equipment
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

Similar Documents

Publication Publication Date Title
JP2013049690A5 (enExample)
JP2017522276A5 (enExample)
TWI546311B (zh) 固殺草ｐ游離酸之製造方法
JP2014524442A5 (enExample)
JP2015110607A5 (enExample)
RU2015143643A (ru) Соль омекамтива мекарбила и способ ее получения
JP2014518287A5 (enExample)
RU2016100972A (ru) Стабильная кристаллическая форма типирацила гидрохлорида и способ ее кристаллизации
JP6378844B2 (ja) 第６結晶形ソホスブビルの調製方法
JP2012001634A5 (enExample)
RU2017123112A (ru) Способ производства кристаллов производного диазабициклооктана и стабильного лиофилизированого препарата
RU2015117524A (ru) Моногидратный кристалл калиевой соли фимасартана, способ его получения и содержащая его фармакологическая композиция
JP2006151999A5 (enExample)
CN102070548B (zh) 一种晶型ⅰ型利奈唑胺的蒸发结晶工艺
WO2012022240A1 (zh) 一种厄洛替尼碱的新晶型及其制备方法
JP2016510767A5 (enExample)
JP2018537495A5 (enExample)
CN104356114A (zh) 一种三水合埃索美拉唑镁的制备方法
AR081267A1 (es) Procedimiento de obtencion de la forma cristalina a del febuxostat
RU2016134404A (ru) КРИСТАЛЛИЧЕСКАЯ ФОРМА α МОНОБЕНЗОАТА СОЕДИНЕНИЯ А, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЕ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
US10787479B2 (en) Crystalline 3′,5′-cyclic diguanylic acid
SI2935255T1 (en) PROCEDURE FOR PREPARATION OF RIVAROKSABAN
JP2018502165A5 (enExample)
JP2020503330A5 (enExample)
JP2010540440A5 (enExample)