JP2010540440A5 - - Google Patents
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- Publication number
- JP2010540440A5 JP2010540440A5 JP2010525845A JP2010525845A JP2010540440A5 JP 2010540440 A5 JP2010540440 A5 JP 2010540440A5 JP 2010525845 A JP2010525845 A JP 2010525845A JP 2010525845 A JP2010525845 A JP 2010525845A JP 2010540440 A5 JP2010540440 A5 JP 2010540440A5
- Authority
- JP
- Japan
- Prior art keywords
- valomaciclovir
- crystalline
- hour
- crystalline valomaciclovir
- purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ATSZELKUSAREPW-ZJUUUORDSA-N [(3r)-3-[(2-amino-6-oxo-3h-purin-9-yl)methyl]-4-hydroxybutyl] (2s)-2-amino-3-methylbutanoate Chemical compound N1C(N)=NC(=O)C2=C1N(C[C@H](CO)CCOC(=O)[C@@H](N)C(C)C)C=N2 ATSZELKUSAREPW-ZJUUUORDSA-N 0.000 claims 11
- 229950004936 valomaciclovir Drugs 0.000 claims 11
- 238000000034 method Methods 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- 238000001816 cooling Methods 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 2
- 239000012046 mixed solvent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99471907P | 2007-09-21 | 2007-09-21 | |
| PCT/US2008/010937 WO2009042081A1 (en) | 2007-09-21 | 2008-09-18 | Valomaciclovir polymorphs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540440A JP2010540440A (ja) | 2010-12-24 |
| JP2010540440A5 true JP2010540440A5 (enExample) | 2011-11-04 |
Family
ID=40511742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525845A Pending JP2010540440A (ja) | 2007-09-21 | 2008-09-18 | バロマシクロビル多形体 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20100240681A1 (enExample) |
| EP (1) | EP2195319A4 (enExample) |
| JP (1) | JP2010540440A (enExample) |
| KR (1) | KR20100061823A (enExample) |
| CN (1) | CN101827846B (enExample) |
| AU (1) | AU2008305666B2 (enExample) |
| CA (1) | CA2700227A1 (enExample) |
| MX (1) | MX2010003056A (enExample) |
| NZ (1) | NZ583607A (enExample) |
| WO (1) | WO2009042081A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011114336A1 (en) * | 2010-03-15 | 2011-09-22 | Hetero Research Foundation | Process for the isolation of ganciclovir intermediate |
| WO2014047562A2 (en) * | 2012-09-21 | 2014-03-27 | Epiphany Biosciences | Method of treating and/or preventing shingles and method of treating and/or preventing zoster associated pain |
| US20220143527A1 (en) * | 2020-11-11 | 2022-05-12 | Purdue Research Foundation | Methods for controlling crystallization based on turbidity and systems therefor |
| WO2024118480A1 (en) * | 2022-11-28 | 2024-06-06 | Epiphany Biosciences | Use of antiviral agents, composition of matter, combination preparations/agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5245716B1 (enExample) | 1970-07-10 | 1977-11-17 | ||
| CN85101404A (zh) | 1985-05-16 | 1987-01-17 | 帝人株式会社 | 头孢菌素衍生物的生产过程 |
| JPH04235188A (ja) | 1990-06-19 | 1992-08-24 | Takeda Chem Ind Ltd | ペネム化合物の結晶、その製造方法および抗菌剤 |
| DE4235133A1 (de) | 1992-10-19 | 1994-04-21 | Bayer Ag | Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid |
| JP3623531B2 (ja) | 1993-06-07 | 2005-02-23 | ビーエーエスエフ アクチェンゲゼルシャフト | 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法 |
| JP3296564B2 (ja) | 1995-07-17 | 2002-07-02 | ワーナー−ランバート・コンパニー | 結晶性の〔Ｒ−（Ｒ▲上＊▼，Ｒ▲上＊▼）〕−２−（４−フルオロフェニル）−β，δ−ジヒドロキシ−５−（１−メチルエチル）−３−フェニル−４−〔（フェニルアミノ）カルボニル〕−１Ｈ−ピロール−１−ヘプタン酸ヘミカルシウム塩（アトルバスタチン） |
| US5869493A (en) * | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| US6184376B1 (en) * | 1997-02-10 | 2001-02-06 | Mediver Ab | Synthesis of acyclic nucleoside derivatives |
| ES2186127T3 (es) * | 1997-02-10 | 2003-05-01 | Medivir Ab | Sintesis de derivados de nucleosidos aciclicos. |
| JPH11139975A (ja) * | 1997-08-26 | 1999-05-25 | Sankyo Co Ltd | Ａ型モノアミンオキシダーゼ阻害薬 |
| US6407241B1 (en) * | 1999-11-08 | 2002-06-18 | Merck & Co., Inc. | Process and intermediates for the preparation of imidazolidinone αv integrin antagonists |
| SE0102273D0 (sv) * | 2001-06-26 | 2001-06-26 | Medivir Ab | Improved synthesis of branched acyclic nucleosides |
| JP4561698B2 (ja) * | 2002-02-19 | 2010-10-13 | 小野薬品工業株式会社 | 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| EP1477175B1 (en) | 2002-02-19 | 2011-04-27 | Ono Pharmaceutical Co., Ltd. | Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient |
| JP2004149451A (ja) * | 2002-10-30 | 2004-05-27 | Fuji Photo Film Co Ltd | ジアゾニウム塩および記録材料 |
| US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
-
2008
- 2008-09-18 AU AU2008305666A patent/AU2008305666B2/en not_active Expired - Fee Related
- 2008-09-18 CN CN2008801086074A patent/CN101827846B/zh not_active Expired - Fee Related
- 2008-09-18 CA CA2700227A patent/CA2700227A1/en not_active Abandoned
- 2008-09-18 NZ NZ583607A patent/NZ583607A/en not_active IP Right Cessation
- 2008-09-18 EP EP08834582A patent/EP2195319A4/en not_active Withdrawn
- 2008-09-18 US US12/676,361 patent/US20100240681A1/en not_active Abandoned
- 2008-09-18 MX MX2010003056A patent/MX2010003056A/es not_active Application Discontinuation
- 2008-09-18 WO PCT/US2008/010937 patent/WO2009042081A1/en not_active Ceased
- 2008-09-18 KR KR1020107007032A patent/KR20100061823A/ko not_active Ceased
- 2008-09-18 JP JP2010525845A patent/JP2010540440A/ja active Pending
-
2013
- 2013-02-27 US US13/778,282 patent/US20130203785A1/en not_active Abandoned
-
2014
- 2014-06-19 US US14/309,580 patent/US9492456B2/en active Active
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