|
DK1007040T3
(da)
*
|
1997-08-21 |
2002-08-26 |
Gerolymatos P N Sa |
Anvendelsen af phanquinon til behandlingen af Alzheimers sygdom
|
|
EP1017375A2
(en)
|
1997-09-24 |
2000-07-12 |
Nova Molecular, Inc. |
Methods for increasing apoe levels for the treatment of neurodegenerative disease
|
|
AR022215A1
(es)
|
1999-01-07 |
2002-09-04 |
Gerolymatos P N Sa |
Utilizacion de la fanquinona para el tratamiento o prevencion del deterioro de la memoria
|
|
EP1157989B1
(en)
|
1999-03-03 |
2004-09-22 |
Eisai Co., Ltd. |
Fluorides of 4-substituted piperidine derivatives
|
|
US20060183776A9
(en)
*
|
2000-03-03 |
2006-08-17 |
Eisai Co., Ltd. |
Liquid dosage formulations of donepezil
|
|
JP2003525903A
(ja)
|
2000-03-03 |
2003-09-02 |
エーザイ株式会社 |
コリンエステラーゼ阻害剤の新規使用法
|
|
AU2001286260A1
(en)
*
|
2000-09-25 |
2002-04-08 |
Eisai Co. Ltd. |
Process for producing multiform crystal of donepezil hydrochloride
|
|
US20050227911A1
(en)
*
|
2001-09-28 |
2005-10-13 |
Solubest Ltd. |
Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules
|
|
US6878693B2
(en)
*
|
2001-09-28 |
2005-04-12 |
Solubest Ltd. |
Hydrophilic complexes of lipophilic materials and an apparatus and method for their production
|
|
US20050191359A1
(en)
*
|
2001-09-28 |
2005-09-01 |
Solubest Ltd. |
Water soluble nanoparticles and method for their production
|
|
US20050249786A1
(en)
*
|
2001-09-28 |
2005-11-10 |
Solubest Ltd. |
Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds
|
|
US20050233003A1
(en)
*
|
2001-09-28 |
2005-10-20 |
Solubest Ltd. |
Hydrophilic dispersions of nanoparticles of inclusion complexes of salicylic acid
|
|
US7700851B2
(en)
*
|
2001-11-13 |
2010-04-20 |
U.S. Smokeless Tobacco Company |
Tobacco nicotine demethylase genomic clone and uses thereof
|
|
WO2003066100A1
(fr)
*
|
2002-02-07 |
2003-08-14 |
Eisai Co., Ltd. |
Stimulants de la pousse de cheveux, preparations percutanees et procede de stimulation de la pousse de cheveux
|
|
NZ536304A
(en)
*
|
2002-05-01 |
2007-06-29 |
San Ei Gen F |
Method for modifying gum arabic
|
|
IL150509A
(en)
|
2002-07-01 |
2007-07-04 |
Joseph Kaspi |
Pharmaceutical preparations containing donafazil hydrochloride
|
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
US20060014801A1
(en)
*
|
2002-11-22 |
2006-01-19 |
The Johns Hopkins University |
Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
|
|
IL154370A0
(en)
*
|
2003-02-10 |
2003-09-17 |
Chemagis Ltd |
Solid amorphous mixtures, processes for the preparation thereof and pharmaceutical compositions containing the same
|
|
US20050288330A1
(en)
*
|
2004-06-29 |
2005-12-29 |
Avinash Naidu |
Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride)
|
|
US7521481B2
(en)
*
|
2003-02-27 |
2009-04-21 |
Mclaurin Joanne |
Methods of preventing, treating and diagnosing disorders of protein aggregation
|
|
AU2003245029A1
(en)
*
|
2003-04-16 |
2004-11-04 |
Hetero Drugs Limited |
Novel crystalline forms of donepezil hydrochloride
|
|
WO2004099142A1
(en)
*
|
2003-05-05 |
2004-11-18 |
Ranbaxy Laboratories Limited |
Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
|
|
UA83504C2
(en)
|
2003-09-04 |
2008-07-25 |
Селджин Корпорейшн |
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
CA2552221A1
(en)
*
|
2003-12-31 |
2005-07-21 |
Actavis Group Hf |
Donepezil formulations
|
|
US7501426B2
(en)
|
2004-02-18 |
2009-03-10 |
Boehringer Ingelheim International Gmbh |
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
|
|
TW200533371A
(en)
*
|
2004-04-15 |
2005-10-16 |
Dainippon Pharmaceutical Co |
Medicament comprising a combination of an acetylcholinesterase inhibitor and a 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1h)-one derivative
|
|
WO2005112946A1
(en)
*
|
2004-05-14 |
2005-12-01 |
The Johns Hopkins University |
Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor
|
|
WO2006015338A2
(en)
*
|
2004-07-30 |
2006-02-09 |
Dr. Reddy's Laboratories Ltd. |
Crystalline form of donepezil hydrochloride
|
|
US7371906B2
(en)
*
|
2004-08-24 |
2008-05-13 |
Eastman Kodak Company |
Process for photo-oxidative stability improvements
|
|
BRPI0515946A
(pt)
*
|
2004-09-29 |
2008-08-12 |
Bayer Healthcare Ag |
sal de tosilato, sua preparação e uso, bem como composição farmacêutica compreendendo o mesmo
|
|
WO2006035433A2
(en)
*
|
2004-09-29 |
2006-04-06 |
Chemagis Ltd. |
Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
|
|
DE602005011326D1
(de)
*
|
2004-10-19 |
2009-01-08 |
Krka Tovarna Zdravil D D |
Feste pharmazeutische zusammensetzung mit donepezilhydrochlorid
|
|
DE102004054054A1
(de)
|
2004-11-05 |
2006-05-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
|
|
DE602005016009D1
(de)
*
|
2004-11-23 |
2009-09-24 |
Warner Lambert Co |
7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure-derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
|
|
US20060122226A1
(en)
*
|
2004-12-08 |
2006-06-08 |
Itai Adin |
Crystalline forms of Donepezil base
|
|
EP2425846A1
(en)
*
|
2004-12-23 |
2012-03-07 |
Voyager Pharmaceutical Corporation |
Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
|
|
WO2006107860A2
(en)
*
|
2005-04-04 |
2006-10-12 |
Eisai Co., Ltd. |
Dihydropyridine compounds and compositions for headaches
|
|
US20070026075A1
(en)
*
|
2005-07-28 |
2007-02-01 |
Jutaro Shudo |
Gelled donepezil compositions and methods for making and using the same
|
|
DE102005035891A1
(de)
|
2005-07-30 |
2007-02-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
US7274339B2
(en)
*
|
2005-09-16 |
2007-09-25 |
Smartant Telecom Co., Ltd. |
Dual-band multi-mode array antenna
|
|
DE102005060377A1
(de)
*
|
2005-12-16 |
2007-06-21 |
Ratiopharm Gmbh |
Pharmazeutische Zusammensetzung enthaltend Donepezilhydrochlorid, Tablette hieraus und Verfahren zu deren Herstellung
|
|
HU227474B1
(en)
*
|
2005-12-20 |
2011-07-28 |
Richter Gedeon Nyrt |
Process for industrial scale production of high purity donepezil hydrochloride polymorph i.
|
|
WO2007108011A2
(en)
*
|
2006-03-20 |
2007-09-27 |
Ind-Swift Laboratories Limited |
Process for the preparation of highly pure donepezil
|
|
EP1852108A1
(en)
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
|
SG174054A1
(en)
|
2006-05-04 |
2011-09-29 |
Boehringer Ingelheim Int |
Polymorphs
|
|
JP5097359B2
(ja)
*
|
2006-05-09 |
2012-12-12 |
久光製薬株式会社 |
ドネペジル経皮吸収型製剤
|
|
AR062927A1
(es)
*
|
2006-10-11 |
2008-12-17 |
Bayer Healthcare Ag |
4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
|
|
AR063319A1
(es)
*
|
2006-10-16 |
2009-01-21 |
Medichem Sa |
Proceso mejorado para preparar la forma polimorfica i de clorhidrato de donepezilo (2,3-dihidro-5,6-dimetoxi-2-[[1-(fenilmetil)-4-piperidin]metil-1h-inden-1-ona)
|
|
AU2007309390A1
(en)
|
2006-10-27 |
2008-05-02 |
Medivation Neurology, Inc. |
Methods and combination therapies for treating Alzheimer's disease
|
|
CA2668748A1
(en)
*
|
2006-11-09 |
2008-05-15 |
Bayer Schering Pharma Aktiengesellschaft |
Polymorph iii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide
|
|
EP2089363A1
(en)
*
|
2006-11-14 |
2009-08-19 |
Bayer Schering Pharma Aktiengesellschaft |
Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]n-methylpyridine-2-carboxamide
|
|
EP2131828A2
(en)
*
|
2007-03-05 |
2009-12-16 |
Eisai R&D Management Co., Ltd. |
Ampa and nmda receptor antagonists for neurodegenerative diseases
|
|
US20100130537A1
(en)
*
|
2007-04-26 |
2010-05-27 |
Eisai R&D Management Co., Ltd |
Cinnamide compounds for dementia
|
|
WO2009084030A2
(en)
*
|
2007-12-03 |
2009-07-09 |
Neuland Laboratories Ltd. |
Improved process for the preparation of (1-benzyl-4-(5,6,- dimethoxyind anone-2-yl)methylpiperidine) hydrochloride-form iii
|
|
PE20140960A1
(es)
|
2008-04-03 |
2014-08-15 |
Boehringer Ingelheim Int |
Formulaciones que comprenden un inhibidor de dpp4
|
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
|
BRPI0916997A2
(pt)
|
2008-08-06 |
2020-12-15 |
Boehringer Ingelheim International Gmbh |
Inibidor de dpp-4 e seu uso
|
|
RU2011113823A
(ru)
|
2008-09-10 |
2012-10-20 |
БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) |
Комбинированная терапия, предназначенная для лечения диабета и связанных с ним состояний
|
|
US20200155558A1
(en)
|
2018-11-20 |
2020-05-21 |
Boehringer Ingelheim International Gmbh |
Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
|
|
JP5488956B2
(ja)
*
|
2008-11-25 |
2014-05-14 |
株式会社Ｄｎｐファインケミカル宇都宮 |
（±）２−（ジメチルアミノ）−１−｛〔Ｏ−（ｍ−メトキシフェネチル）フェノキシ〕メチル｝エチル水素サクシナート塩酸塩のＩ形結晶とＩＩ形結晶の混晶の製造法
|
|
EP2382216A1
(en)
|
2008-12-23 |
2011-11-02 |
Boehringer Ingelheim International GmbH |
Salt forms of organic compound
|
|
AR074990A1
(es)
|
2009-01-07 |
2011-03-02 |
Boehringer Ingelheim Int |
Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
|
|
WO2011061591A1
(en)
|
2009-11-18 |
2011-05-26 |
Jubilant Life Sciences Limited |
Improved process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanone)-2-yl)methyl piperidine hydrochloride form-iii
|
|
EP3646859A1
(en)
|
2009-11-27 |
2020-05-06 |
Boehringer Ingelheim International GmbH |
Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
|
|
IT1397912B1
(it)
*
|
2010-01-28 |
2013-02-04 |
Chemi Spa |
Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato.
|
|
EP2533645B1
(en)
|
2010-02-09 |
2016-07-27 |
The Johns Hopkins University |
Methods and compositions for improving cognitive function
|
|
EP2366378A1
(en)
|
2010-03-01 |
2011-09-21 |
Dexcel Pharma Technologies Ltd. |
Sustained-release donepezil formulations
|
|
WO2011127235A1
(en)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Combination therapy for the treatment of dementia
|
|
KR20130094185A
(ko)
*
|
2010-04-07 |
2013-08-23 |
오닉스 세라퓨틱스, 인크. |
결정성 펩티드 에폭시케톤 면역프로테아좀 저해제
|
|
NZ602921A
(en)
|
2010-05-05 |
2016-01-29 |
Boehringer Ingelheim Int |
Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor
|
|
WO2011151359A1
(en)
|
2010-06-02 |
2011-12-08 |
Noscira, S.A. |
Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative
|
|
KR20230051307A
(ko)
|
2010-06-24 |
2023-04-17 |
베링거 인겔하임 인터내셔날 게엠베하 |
당뇨병 요법
|
|
US20130267560A1
(en)
|
2010-10-22 |
2013-10-10 |
Cadila Healthcare Limited |
Sustained release pharmaceutical compositions of donepezil
|
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
|
AU2012285904C1
(en)
|
2011-07-15 |
2017-08-31 |
Boehringer Ingelheim International Gmbh |
Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
|
|
US9555001B2
(en)
|
2012-03-07 |
2017-01-31 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition and uses thereof
|
|
US20130303462A1
(en)
|
2012-05-14 |
2013-11-14 |
Boehringer Ingelheim International Gmbh |
Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
|
|
EP4151218A1
(en)
|
2012-05-14 |
2023-03-22 |
Boehringer Ingelheim International GmbH |
Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
|
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
|
EP2919788A4
(en)
|
2012-11-14 |
2016-05-25 |
Univ Johns Hopkins |
METHOD AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA
|
|
CN103012247B
(zh)
*
|
2013-01-18 |
2014-12-10 |
浙江东亚药业有限公司 |
一种盐酸多奈哌齐无水i晶型的制备方法
|
|
CN103965188A
(zh)
*
|
2013-01-29 |
2014-08-06 |
中山大学 |
含硒多奈哌齐类似物
|
|
WO2014144801A1
(en)
|
2013-03-15 |
2014-09-18 |
Agenebio Inc. |
Methods and compositions for improving cognitive function
|
|
EP3827820A1
(en)
|
2013-03-15 |
2021-06-02 |
The Johns Hopkins University |
Brivaracetam for improving cognitive function
|
|
US10357486B2
(en)
|
2013-08-16 |
2019-07-23 |
Universiteit Maastricht |
Treatment of cognitive impairment with PDE4 inhibitor
|
|
EP3110449B1
(en)
|
2014-02-28 |
2023-06-28 |
Boehringer Ingelheim International GmbH |
Medical use of a dpp-4 inhibitor
|
|
CN112843005B
(zh)
|
2015-05-22 |
2023-02-21 |
艾吉因生物股份有限公司 |
左乙拉西坦的延时释放药物组合物
|
|
EP3468562A1
(en)
|
2016-06-10 |
2019-04-17 |
Boehringer Ingelheim International GmbH |
Combinations of linagliptin and metformin
|
|
CN106397306B
(zh)
*
|
2016-10-20 |
2019-03-08 |
山东罗欣药业集团股份有限公司 |
一种盐酸多奈哌齐晶型化合物及其制备方法
|
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
|
PE20220936A1
(es)
|
2019-05-31 |
2022-05-31 |
Tecnimede Sociedade Tecnico Medicinal Sa |
Composiciones farmaceuticas de combinacion a dosis fijas de liberacion inmediata, metodos y usos de las mismas
|
|
WO2024145319A1
(en)
|
2022-12-28 |
2024-07-04 |
Corium, Llc |
Method of preparing transdermal delivery system
|
|
WO2024145323A1
(en)
|
2022-12-28 |
2024-07-04 |
Corium, Llc |
Pre-mixing method of preparing transdermal delivery system
|