CN101827846B - 伐马洛韦多形体 - Google Patents

伐马洛韦多形体 Download PDF

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Publication number
CN101827846B
CN101827846B CN2008801086074A CN200880108607A CN101827846B CN 101827846 B CN101827846 B CN 101827846B CN 2008801086074 A CN2008801086074 A CN 2008801086074A CN 200880108607 A CN200880108607 A CN 200880108607A CN 101827846 B CN101827846 B CN 101827846B
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CN
China
Prior art keywords
polymorph
crystalline
valamaclovir
group
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008801086074A
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English (en)
Chinese (zh)
Other versions
CN101827846A (zh
Inventor
M·H·奥奈尔
G·P·布特克
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Epiphany Biosciences Inc
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Epiphany Biosciences Inc
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Publication of CN101827846A publication Critical patent/CN101827846A/zh
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Publication of CN101827846B publication Critical patent/CN101827846B/zh
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2008801086074A 2007-09-21 2008-09-18 伐马洛韦多形体 Expired - Fee Related CN101827846B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99471907P 2007-09-21 2007-09-21
US60/994,719 2007-09-21
PCT/US2008/010937 WO2009042081A1 (en) 2007-09-21 2008-09-18 Valomaciclovir polymorphs

Publications (2)

Publication Number Publication Date
CN101827846A CN101827846A (zh) 2010-09-08
CN101827846B true CN101827846B (zh) 2012-08-15

Family

ID=40511742

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801086074A Expired - Fee Related CN101827846B (zh) 2007-09-21 2008-09-18 伐马洛韦多形体

Country Status (10)

Country Link
US (3) US20100240681A1 (enExample)
EP (1) EP2195319A4 (enExample)
JP (1) JP2010540440A (enExample)
KR (1) KR20100061823A (enExample)
CN (1) CN101827846B (enExample)
AU (1) AU2008305666B2 (enExample)
CA (1) CA2700227A1 (enExample)
MX (1) MX2010003056A (enExample)
NZ (1) NZ583607A (enExample)
WO (1) WO2009042081A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011114336A1 (en) * 2010-03-15 2011-09-22 Hetero Research Foundation Process for the isolation of ganciclovir intermediate
WO2014047562A2 (en) * 2012-09-21 2014-03-27 Epiphany Biosciences Method of treating and/or preventing shingles and method of treating and/or preventing zoster associated pain
US20220143527A1 (en) * 2020-11-11 2022-05-12 Purdue Research Foundation Methods for controlling crystallization based on turbidity and systems therefor
WO2024118480A1 (en) * 2022-11-28 2024-06-06 Epiphany Biosciences Use of antiviral agents, composition of matter, combination preparations/agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407241B1 (en) * 1999-11-08 2002-06-18 Merck & Co., Inc. Process and intermediates for the preparation of imidazolidinone αv integrin antagonists
US7189849B2 (en) * 1997-02-10 2007-03-13 Medivir Ab Synthesis of acyclic nucleoside derivatives

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5245716B1 (enExample) 1970-07-10 1977-11-17
CN85101404A (zh) 1985-05-16 1987-01-17 帝人株式会社 头孢菌素衍生物的生产过程
JPH04235188A (ja) 1990-06-19 1992-08-24 Takeda Chem Ind Ltd ペネム化合物の結晶、その製造方法および抗菌剤
DE4235133A1 (de) 1992-10-19 1994-04-21 Bayer Ag Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid
JP3623531B2 (ja) 1993-06-07 2005-02-23 ビーエーエスエフ アクチェンゲゼルシャフト 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法
EA000474B1 (ru) 1995-07-17 1999-08-26 Варнер-Ламберт Компани Кристаллическая кислая кальциевая соль [r-(r*, r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты (аторвастатин)
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
ES2186127T3 (es) 1997-02-10 2003-05-01 Medivir Ab Sintesis de derivados de nucleosidos aciclicos.
JPH11139975A (ja) * 1997-08-26 1999-05-25 Sankyo Co Ltd Ａ型モノアミンオキシダーゼ阻害薬
SE0102273D0 (sv) 2001-06-26 2001-06-26 Medivir Ab Improved synthesis of branched acyclic nucleosides
AU2003211381B9 (en) 2002-02-19 2009-07-30 Ono Pharmaceutical Co., Ltd. Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient
JP4561698B2 (ja) * 2002-02-19 2010-10-13 小野薬品工業株式会社 縮合ピリダジン誘導体化合物およびその化合物を有効成分として含有する薬剤
JP2004149451A (ja) * 2002-10-30 2004-05-27 Fuji Photo Film Co Ltd ジアゾニウム塩および記録材料
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189849B2 (en) * 1997-02-10 2007-03-13 Medivir Ab Synthesis of acyclic nucleoside derivatives
US6407241B1 (en) * 1999-11-08 2002-06-18 Merck & Co., Inc. Process and intermediates for the preparation of imidazolidinone αv integrin antagonists

Also Published As

Publication number Publication date
JP2010540440A (ja) 2010-12-24
US20150051229A1 (en) 2015-02-19
WO2009042081A1 (en) 2009-04-02
EP2195319A4 (en) 2011-09-14
US20100240681A1 (en) 2010-09-23
MX2010003056A (es) 2010-04-07
KR20100061823A (ko) 2010-06-09
CA2700227A1 (en) 2009-04-02
US20130203785A1 (en) 2013-08-08
HK1148007A1 (en) 2011-08-26
AU2008305666A1 (en) 2009-04-02
CN101827846A (zh) 2010-09-08
US9492456B2 (en) 2016-11-15
AU2008305666B2 (en) 2014-08-28
EP2195319A1 (en) 2010-06-16
NZ583607A (en) 2012-06-29

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