BRPI0714886B8 - sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica - Google Patents

sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica

Info

Publication number
BRPI0714886B8
BRPI0714886B8 BRPI0714886A BRPI0714886A BRPI0714886B8 BR PI0714886 B8 BRPI0714886 B8 BR PI0714886B8 BR PI0714886 A BRPI0714886 A BR PI0714886A BR PI0714886 A BRPI0714886 A BR PI0714886A BR PI0714886 B8 BRPI0714886 B8 BR PI0714886B8
Authority
BR
Brazil
Prior art keywords
salts
pharmaceutical composition
preparation processes
benzodiazepine
benzodiazepine salts
Prior art date
Application number
BRPI0714886A
Other languages
English (en)
Portuguese (pt)
Inventor
Stuart Tilbrook Gary
Jane Cubitt Louisa
Original Assignee
Paion Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0613694A external-priority patent/GB0613694D0/en
Priority claimed from GB0613692A external-priority patent/GB0613692D0/en
Application filed by Paion Uk Ltd filed Critical Paion Uk Ltd
Publication of BRPI0714886A2 publication Critical patent/BRPI0714886A2/pt
Publication of BRPI0714886B1 publication Critical patent/BRPI0714886B1/pt
Publication of BRPI0714886B8 publication Critical patent/BRPI0714886B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Steroid Compounds (AREA)
BRPI0714886A 2006-07-10 2007-07-10 sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica BRPI0714886B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0613694A GB0613694D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts
GB06136949 2006-07-10
GB0613692A GB0613692D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts
GB06136923 2006-07-10
PCT/GB2007/002565 WO2008007071A1 (en) 2006-07-10 2007-07-10 Short-acting benzodiazepine salts and their polymorphic forms

Publications (3)

Publication Number Publication Date
BRPI0714886A2 BRPI0714886A2 (pt) 2013-03-26
BRPI0714886B1 BRPI0714886B1 (pt) 2021-04-13
BRPI0714886B8 true BRPI0714886B8 (pt) 2021-05-25

Family

ID=38535381

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0714886A BRPI0714886B8 (pt) 2006-07-10 2007-07-10 sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica

Country Status (17)

Country Link
US (7) US9193730B2 (enExample)
EP (1) EP2081921B1 (enExample)
JP (2) JP5433413B2 (enExample)
KR (3) KR20090045233A (enExample)
CN (3) CN104059072B (enExample)
AT (1) ATE480532T1 (enExample)
AU (1) AU2007274054B2 (enExample)
BR (1) BRPI0714886B8 (enExample)
CA (1) CA2657347C (enExample)
DE (1) DE602007009128D1 (enExample)
DK (1) DK2081921T3 (enExample)
MX (1) MX2009000404A (enExample)
PL (1) PL2081921T3 (enExample)
PT (1) PT2081921E (enExample)
RU (1) RU2470935C2 (enExample)
SI (1) SI2081921T1 (enExample)
WO (1) WO2008007071A1 (enExample)

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GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
ATE480532T1 (de) 2006-07-10 2010-09-15 Paion Uk Ltd Benzodiazepinsalze mit kurzzeitwirkung und polymorphe formen davon
EP2305647A1 (en) * 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
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EP4556068A3 (en) * 2016-04-14 2025-07-23 Paion UK Limited Orally inhaled and nasal benzodiazepines
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途
ES2916845T3 (es) 2017-02-09 2022-07-06 Assia Chem Ind Ltd Proceso para la preparación de remimazolam y formas en estado sólido de sales de remimazolam
CN108948018B (zh) * 2017-05-17 2021-03-30 四川科伦博泰生物医药股份有限公司 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途
AU2019222052B2 (en) 2018-02-13 2022-05-12 Jiangsu Nhwaluokang Pharmaceutical Research And Development Co., Ltd. Benzodiazepine derivative hydrochloride and crystal form, preparation method, and application thereof
CN110398514B (zh) * 2018-04-24 2023-04-28 恒天纤维集团有限公司 一种快速判断纤维素胶液中金属杂质含量的方法
ES2803099B2 (es) * 2019-07-22 2021-11-08 Moehs Iberica Sl Procedimiento de obtención de besilato de remimazolam amorfo
CN114478535B (zh) * 2020-10-23 2024-02-09 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法
WO2023037237A1 (en) * 2021-09-09 2023-03-16 Wavelength Enterprises Ltd Process for the preparation of remimazolam
EP4504731A1 (en) 2022-04-08 2025-02-12 Fresenius Kabi Oncology Ltd An improved process for the preparation of remimazolam
CN115448927A (zh) * 2022-10-20 2022-12-09 重庆瑞泊莱医药科技有限公司 一种氢溴酸依匹斯汀晶型ii及其制备方法
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CA2657347A1 (en) 2008-01-17
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BRPI0714886A2 (pt) 2013-03-26
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US12365684B2 (en) 2025-07-22
US20180186803A1 (en) 2018-07-05
US9914738B2 (en) 2018-03-13
US20210261556A1 (en) 2021-08-26
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KR20170091770A (ko) 2017-08-09
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JP5785923B2 (ja) 2015-09-30
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KR20090045233A (ko) 2009-05-07
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WO2008007071A1 (en) 2008-01-17
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US20180002338A1 (en) 2018-01-04
US9777007B2 (en) 2017-10-03
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US10961250B2 (en) 2021-03-30
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US9193730B2 (en) 2015-11-24
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