JP2015519375A - Ｐｄ−ｌ１に結合する抗原結合蛋白質 - Google Patents

Ｐｄ−ｌ１に結合する抗原結合蛋白質 Download PDF

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JP2015519375A
JP2015519375A JP2015515271A JP2015515271A JP2015519375A JP 2015519375 A JP2015519375 A JP 2015519375A JP 2015515271 A JP2015515271 A JP 2015515271A JP 2015515271 A JP2015515271 A JP 2015515271A JP 2015519375 A JP2015519375 A JP 2015519375A
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variable region
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ヘユー・ジョウ
ランディ・ギャストワート
バーバラ・エイ・スワンソン
ジョン・ディクソン・グレイ
ガナー・エフ・カウフマン
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Sorrento Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015515271A 2012-05-31 2013-05-31 Ｐｄ−ｌ１に結合する抗原結合蛋白質 Pending JP2015519375A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261654022P 2012-05-31 2012-05-31
US61/654,022 2012-05-31
US201261739982P 2012-12-20 2012-12-20
US61/739,982 2012-12-20
PCT/US2013/043775 WO2013181634A2 (en) 2012-05-31 2013-05-31 Antigen binding proteins that bind pd-l1

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JP2017155655A Division JP6648080B2 (ja) 2012-05-31 2017-08-10 Ｐｄ−ｌ１に結合する抗原結合蛋白質

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JP2015519375A true JP2015519375A (ja) 2015-07-09
JP2015519375A5 JP2015519375A5 (https=) 2016-07-14

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JP2015515271A Pending JP2015519375A (ja) 2012-05-31 2013-05-31 Ｐｄ−ｌ１に結合する抗原結合蛋白質
JP2017155655A Active JP6648080B2 (ja) 2012-05-31 2017-08-10 Ｐｄ−ｌ１に結合する抗原結合蛋白質
JP2020004101A Active JP6829330B2 (ja) 2012-05-31 2020-01-15 Ｐｄ−ｌ１に結合する抗原結合蛋白質
JP2021008088A Pending JP2021061862A (ja) 2012-05-31 2021-01-21 Ｐｄ−ｌ１に結合する抗原結合蛋白質
JP2022017798A Pending JP2022058932A (ja) 2012-05-31 2022-02-08 Ｐｄ－ｌ１に結合する抗原結合蛋白質

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JP2020004101A Active JP6829330B2 (ja) 2012-05-31 2020-01-15 Ｐｄ−ｌ１に結合する抗原結合蛋白質
JP2021008088A Pending JP2021061862A (ja) 2012-05-31 2021-01-21 Ｐｄ−ｌ１に結合する抗原結合蛋白質
JP2022017798A Pending JP2022058932A (ja) 2012-05-31 2022-02-08 Ｐｄ－ｌ１に結合する抗原結合蛋白質

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US (5) US9175082B2 (https=)
EP (2) EP3553086A1 (https=)
JP (5) JP2015519375A (https=)
KR (4) KR20220084444A (https=)
CN (3) CN109467601B (https=)
AU (4) AU2013267161A1 (https=)
BR (1) BR112014029883B1 (https=)
CA (2) CA3175758A1 (https=)
CO (1) CO7160115A2 (https=)
HK (1) HK1204557A1 (https=)
WO (1) WO2013181634A2 (https=)

Cited By (11)

* Cited by examiner, † Cited by third party
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JP2018526974A (ja) * 2016-03-04 2018-09-20 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド Ｐｄｌ−１抗体、その医薬組成物及びその使用
JP2018531219A (ja) * 2015-08-24 2018-10-25 イーライ リリー アンド カンパニー Ｐｄ−ｌ１抗体
JP2019503687A (ja) * 2016-01-04 2019-02-14 ジアンスー ヒャマブ ファーマシューティカル カンパニー リミテッド 抗ｐｄ−ｌ１抗体およびその使用
JP2019510041A (ja) * 2016-03-30 2019-04-11 マイクロバイオ カンパニー， リミテッド 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法
JP2019514853A (ja) * 2016-05-20 2019-06-06 ルェヤン（スーツォ）バイオロジー サイエンス アンド テクノロジー シーオー．，エルティーディー 抗人ｐｄ−ｌ１人源化単クローン抗体及び応用
JP2019516394A (ja) * 2016-03-23 2019-06-20 マブスペース バイオサイエンシズ （スーチョウ） カンパニー，リミテッド 新規抗ｐｄ−ｌ１抗体
JP2021509258A (ja) * 2017-12-29 2021-03-25 エーピー バイオサイエンスィズ インコーポレイテッド 癌治療のために免疫チェックポイントを調節する単一特異性および二重特異性タンパク質
JP2021102633A (ja) * 2016-01-29 2021-07-15 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｐｄ−ｌ１に結合する抗原結合性タンパク質
JP2021534750A (ja) * 2018-08-20 2021-12-16 １グローブ バイオメディカル カンパニー， リミテッド 新規ながん免疫療法抗体組成物
JP2022511311A (ja) * 2019-04-26 2022-01-31 アイ－エムエービー バイオファーマ ユーエス リミテッド ヒトｐｄ‐ｌ１抗体
JP2022528007A (ja) * 2019-06-10 2022-06-07 山東博安生物技術股▲ふん▼有限公司 ＰＤＬ１及びＴＧＦβに対する二機能性融合タンパク質並びにその使用

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CA2863658C (en) * 2012-02-03 2023-03-14 Emory University Immunostimulatory compositions, particles, and uses related thereto
HK1204557A1 (en) 2012-05-31 2015-11-27 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-l1
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EA034666B1 (ru) 2013-09-13 2020-03-04 Бейджин Свитзерланд Гмбх Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела
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MX2016007885A (es) * 2013-12-17 2017-01-11 Genentech Inc Metodos de tratamiento de cancer usando antagonistas de union del eje de pd-1 y un anticuerpo anti-cd20.
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MA39848A (fr) * 2014-04-16 2017-02-22 Sorrento Therapeutics Inc Agents thérapeutiques de type anticorps se liant à cd147
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TWI716362B (zh) 2014-10-14 2021-01-21 瑞士商諾華公司 針對ｐｄ－ｌ１之抗體分子及其用途
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