JP2013528181A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013528181A5 JP2013528181A5 JP2013512256A JP2013512256A JP2013528181A5 JP 2013528181 A5 JP2013528181 A5 JP 2013528181A5 JP 2013512256 A JP2013512256 A JP 2013512256A JP 2013512256 A JP2013512256 A JP 2013512256A JP 2013528181 A5 JP2013528181 A5 JP 2013528181A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- protein
- antigen
- derived
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 47
- 102000036639 antigens Human genes 0.000 claims 47
- 108091007433 antigens Proteins 0.000 claims 47
- 239000002552 dosage form Substances 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 19
- 241000701806 Human papillomavirus Species 0.000 claims 12
- 239000002539 nanocarrier Substances 0.000 claims 11
- 239000002105 nanoparticle Substances 0.000 claims 9
- -1 aminoalkyl glucosaminide Chemical class 0.000 claims 7
- 230000003308 immunostimulating effect Effects 0.000 claims 7
- 241000712431 Influenza A virus Species 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 6
- 239000002158 endotoxin Substances 0.000 claims 6
- 229920006008 lipopolysaccharide Polymers 0.000 claims 6
- 241000712461 unidentified influenza virus Species 0.000 claims 6
- 241000607142 Salmonella Species 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 101710154606 Hemagglutinin Proteins 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 4
- 101710176177 Protein A56 Proteins 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 4
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 4
- 239000000185 hemagglutinin Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- WSIZDLIFQIDDKA-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinolin-2-amine Chemical compound C1=CC=NC2=C(NC(N)=N3)C3=CC=C21 WSIZDLIFQIDDKA-UHFFFAOYSA-N 0.000 claims 3
- 241000588807 Bordetella Species 0.000 claims 3
- 241000589562 Brucella Species 0.000 claims 3
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims 3
- 241000233870 Pneumocystis Species 0.000 claims 3
- 241000712907 Retroviridae Species 0.000 claims 3
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- CTMZLDSMFCVUNX-VMIOUTBZSA-N cytidylyl-(3'->5')-guanosine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)[C@@H](CO)O1 CTMZLDSMFCVUNX-VMIOUTBZSA-N 0.000 claims 3
- 229940124669 imidazoquinoline Drugs 0.000 claims 3
- 229960002751 imiquimod Drugs 0.000 claims 3
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 201000000317 pneumocystosis Diseases 0.000 claims 3
- 229920000728 polyester Polymers 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229950010550 resiquimod Drugs 0.000 claims 3
- BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 claims 2
- 229940031767 13-valent pneumococcal conjugate vaccine Drugs 0.000 claims 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000589875 Campylobacter jejuni Species 0.000 claims 2
- 241000606161 Chlamydia Species 0.000 claims 2
- 241000606153 Chlamydia trachomatis Species 0.000 claims 2
- 241000193163 Clostridioides difficile Species 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 241000186216 Corynebacterium Species 0.000 claims 2
- 241000194032 Enterococcus faecalis Species 0.000 claims 2
- 101710091045 Envelope protein Proteins 0.000 claims 2
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 claims 2
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 229940124913 IPOL Drugs 0.000 claims 2
- 102100034349 Integrase Human genes 0.000 claims 2
- 102000002227 Interferon Type I Human genes 0.000 claims 2
- 108010014726 Interferon Type I Proteins 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 241000186359 Mycobacterium Species 0.000 claims 2
- 241000588653 Neisseria Species 0.000 claims 2
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims 2
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 2
- 102000011931 Nucleoproteins Human genes 0.000 claims 2
- 108010061100 Nucleoproteins Proteins 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 241001631646 Papillomaviridae Species 0.000 claims 2
- 241000711504 Paramyxoviridae Species 0.000 claims 2
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims 2
- 101710188315 Protein X Proteins 0.000 claims 2
- 108010031852 Pyruvate Synthase Proteins 0.000 claims 2
- 241000711931 Rhabdoviridae Species 0.000 claims 2
- 241000606701 Rickettsia Species 0.000 claims 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 2
- 241000193985 Streptococcus agalactiae Species 0.000 claims 2
- 241000710924 Togaviridae Species 0.000 claims 2
- 108010060804 Toll-Like Receptor 4 Proteins 0.000 claims 2
- 108010060825 Toll-Like Receptor 7 Proteins 0.000 claims 2
- 108010060752 Toll-Like Receptor 8 Proteins 0.000 claims 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 2
- 102000008228 Toll-like receptor 2 Human genes 0.000 claims 2
- 108010060888 Toll-like receptor 2 Proteins 0.000 claims 2
- 102000008230 Toll-like receptor 3 Human genes 0.000 claims 2
- 108010060885 Toll-like receptor 3 Proteins 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 102000008234 Toll-like receptor 5 Human genes 0.000 claims 2
- 108010060812 Toll-like receptor 5 Proteins 0.000 claims 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 2
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims 2
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims 2
- 241000607626 Vibrio cholerae Species 0.000 claims 2
- 229940037003 alum Drugs 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 claims 2
- 229940038705 chlamydia trachomatis Drugs 0.000 claims 2
- 206010013023 diphtheria Diseases 0.000 claims 2
- 229940032049 enterococcus faecalis Drugs 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 2
- 208000002672 hepatitis B Diseases 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 108010021711 pertactin Proteins 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 229920001983 poloxamer Polymers 0.000 claims 2
- 229920000570 polyether Polymers 0.000 claims 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
- 229930182490 saponin Natural products 0.000 claims 2
- 150000007949 saponins Chemical class 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 229940118696 vibrio cholerae Drugs 0.000 claims 2
- FCZOVUJWOBSMSS-UHFFFAOYSA-N 5-[(6-aminopurin-9-yl)methyl]-5-methyl-3-methylideneoxolan-2-one Chemical compound C1=NC2=C(N)N=CN=C2N1CC1(C)CC(=C)C(=O)O1 FCZOVUJWOBSMSS-UHFFFAOYSA-N 0.000 claims 1
- MKAXTWZVXLPMCF-UHFFFAOYSA-N 6-nitroso-7h-purine Chemical compound O=NC1=NC=NC2=C1NC=N2 MKAXTWZVXLPMCF-UHFFFAOYSA-N 0.000 claims 1
- 229940124965 ACAM2000 Drugs 0.000 claims 1
- 229940124962 ActHIB Drugs 0.000 claims 1
- 241000701242 Adenoviridae Species 0.000 claims 1
- 229940124963 Afluria Drugs 0.000 claims 1
- 229940124838 Agriflu Drugs 0.000 claims 1
- 101710145634 Antigen 1 Proteins 0.000 claims 1
- 241000228212 Aspergillus Species 0.000 claims 1
- 241000228197 Aspergillus flavus Species 0.000 claims 1
- 241001225321 Aspergillus fumigatus Species 0.000 claims 1
- 241000193738 Bacillus anthracis Species 0.000 claims 1
- 229940124899 Biothrax Drugs 0.000 claims 1
- 229940124900 Boostrix Drugs 0.000 claims 1
- 241000589968 Borrelia Species 0.000 claims 1
- 241000589567 Brucella abortus Species 0.000 claims 1
- 241001509299 Brucella canis Species 0.000 claims 1
- 241001148106 Brucella melitensis Species 0.000 claims 1
- 241001148111 Brucella suis Species 0.000 claims 1
- 101710158075 Bucky ball Proteins 0.000 claims 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 claims 1
- 108090000565 Capsid Proteins Proteins 0.000 claims 1
- 102100023321 Ceruloplasmin Human genes 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 241001647378 Chlamydia psittaci Species 0.000 claims 1
- 241000193155 Clostridium botulinum Species 0.000 claims 1
- 241000193468 Clostridium perfringens Species 0.000 claims 1
- 241000193449 Clostridium tetani Species 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 229940124901 Comvax Drugs 0.000 claims 1
- 241000186227 Corynebacterium diphtheriae Species 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 229940124888 DECAVAC Drugs 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 229940124902 Daptacel Drugs 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 101710174216 Early E3 18.5 kDa glycoprotein Proteins 0.000 claims 1
- 206010014596 Encephalitis Japanese B Diseases 0.000 claims 1
- 241000305071 Enterobacterales Species 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241001517310 Eria Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 229940124894 Fluzone Drugs 0.000 claims 1
- 241000589601 Francisella Species 0.000 claims 1
- 241000589602 Francisella tularensis Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108060003393 Granulin Proteins 0.000 claims 1
- 206010069767 H1N1 influenza Diseases 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 229940124914 Havrix Drugs 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 241000590002 Helicobacter pylori Species 0.000 claims 1
- 101710133291 Hemagglutinin-neuraminidase Proteins 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700739 Hepadnaviridae Species 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 208000007514 Herpes zoster Diseases 0.000 claims 1
- 241000700586 Herpesviridae Species 0.000 claims 1
- 229940124885 Hiberix Drugs 0.000 claims 1
- 108700020122 Hiberix Proteins 0.000 claims 1
- 241000228402 Histoplasma Species 0.000 claims 1
- 241000282414 Homo sapiens Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- 241000046923 Human bocavirus Species 0.000 claims 1
- 101100048372 Human cytomegalovirus (strain AD169) H301 gene Proteins 0.000 claims 1
- 101100048373 Human cytomegalovirus (strain Merlin) UL18 gene Proteins 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241000342334 Human metapneumovirus Species 0.000 claims 1
- 241000702617 Human parvovirus B19 Species 0.000 claims 1
- 101900330356 Influenza A virus Matrix protein 2 Proteins 0.000 claims 1
- 229940124956 Ixiaro Drugs 0.000 claims 1
- 201000005807 Japanese encephalitis Diseases 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 229940124919 Kinrix Drugs 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 241000589242 Legionella pneumophila Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 241000589929 Leptospira interrogans Species 0.000 claims 1
- 108010028921 Lipopeptides Proteins 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 101150047390 MCP gene Proteins 0.000 claims 1
- 201000005505 Measles Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 229940124904 Menactra Drugs 0.000 claims 1
- 229940124951 Menveo Drugs 0.000 claims 1
- 108010006519 Molecular Chaperones Proteins 0.000 claims 1
- 241000108056 Monas Species 0.000 claims 1
- 208000005647 Mumps Diseases 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 241000186362 Mycobacterium leprae Species 0.000 claims 1
- 241000187917 Mycobacterium ulcerans Species 0.000 claims 1
- 241000204031 Mycoplasma Species 0.000 claims 1
- 241000202934 Mycoplasma pneumoniae Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010006232 Neuraminidase Proteins 0.000 claims 1
- 102000005348 Neuraminidase Human genes 0.000 claims 1
- 101710144111 Non-structural protein 3 Proteins 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 108700006640 OspA Proteins 0.000 claims 1
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 claims 1
- 101150112800 PE35 gene Proteins 0.000 claims 1
- 101150009192 PPE68 gene Proteins 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 229940124908 Pediarix Drugs 0.000 claims 1
- 229940124909 PedvaxHIB Drugs 0.000 claims 1
- 229940124910 Pentacel Drugs 0.000 claims 1
- 102000010562 Peptide Elongation Factor G Human genes 0.000 claims 1
- 108010077742 Peptide Elongation Factor G Proteins 0.000 claims 1
- 101710103914 Perfringolysin O Proteins 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 208000035109 Pneumococcal Infections Diseases 0.000 claims 1
- 208000000474 Poliomyelitis Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229940124876 ProQuad Drugs 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 241000125945 Protoparvovirus Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 229940124875 RabAvert Drugs 0.000 claims 1
- 206010037742 Rabies Diseases 0.000 claims 1
- 241000711798 Rabies lyssavirus Species 0.000 claims 1
- 101100457322 Rattus norvegicus Mipep gene Proteins 0.000 claims 1
- 101100431670 Rattus norvegicus Ybx3 gene Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 229940124878 RotaTeq Drugs 0.000 claims 1
- 229940124941 Rotarix Drugs 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000710799 Rubella virus Species 0.000 claims 1
- 101150103019 SCP gene Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 241001279361 Stachybotrys Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241001147691 Staphylococcus saprophyticus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 claims 1
- 201000005010 Streptococcus pneumonia Diseases 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 101150102071 TRX1 gene Proteins 0.000 claims 1
- 101150037769 TRX2 gene Proteins 0.000 claims 1
- 229940124929 TYPHIM Vi Drugs 0.000 claims 1
- 206010043376 Tetanus Diseases 0.000 claims 1
- 208000004006 Tick-borne encephalitis Diseases 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 241000589886 Treponema Species 0.000 claims 1
- 241000589884 Treponema pallidum Species 0.000 claims 1
- 229940124923 Tripedia Drugs 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 208000037386 Typhoid Diseases 0.000 claims 1
- 101150109748 UL19 gene Proteins 0.000 claims 1
- 101150023000 UL35 gene Proteins 0.000 claims 1
- 101150090946 UL38 gene Proteins 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 229940124937 Vaqta Drugs 0.000 claims 1
- 229940124924 Varivax Drugs 0.000 claims 1
- 241000607598 Vibrio Species 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 229940124928 YF-Vax Drugs 0.000 claims 1
- 208000003152 Yellow Fever Diseases 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 241000607734 Yersinia <bacteria> Species 0.000 claims 1
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 1
- JWPRTLPEVKPSEG-UHFFFAOYSA-N [6'-acetyloxy-6-[3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propylcarbamoyl]-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] acetate Chemical compound C1=C(C=2C(NC(=O)C=2C=2C3=CC=CC=C3N(C)C=2)=O)C2=CC=CC=C2N1CCCNC(=O)C(C=C12)=CC=C2C(=O)OC21C1=CC=C(OC(C)=O)C=C1OC1=CC(OC(=O)C)=CC=C21 JWPRTLPEVKPSEG-UHFFFAOYSA-N 0.000 claims 1
- 229940102614 adacel Drugs 0.000 claims 1
- 108700010877 adenoviridae proteins Proteins 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 229940091771 aspergillus fumigatus Drugs 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims 1
- 229940056450 brucella abortus Drugs 0.000 claims 1
- 229940038698 brucella melitensis Drugs 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 102000006834 complement receptors Human genes 0.000 claims 1
- 108010047295 complement receptors Proteins 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 239000000409 cytokine receptor agonist Substances 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229940118764 francisella tularensis Drugs 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 108010048607 glycerophosphodiester phosphodiesterase Proteins 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 1
- 229940037467 helicobacter pylori Drugs 0.000 claims 1
- 208000005252 hepatitis A Diseases 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 229940115932 legionella pneumophila Drugs 0.000 claims 1
- 150000002632 lipids Chemical group 0.000 claims 1
- 229940102700 m-m-r ii Drugs 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 208000037941 meningococcal disease Diseases 0.000 claims 1
- 239000002082 metal nanoparticle Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 101150075489 mip gene Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 208000010805 mumps infectious disease Diseases 0.000 claims 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 claims 1
- 239000002070 nanowire Substances 0.000 claims 1
- 230000001338 necrotic effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229940092253 ovalbumin Drugs 0.000 claims 1
- 102000007863 pattern recognition receptors Human genes 0.000 claims 1
- 108010089193 pattern recognition receptors Proteins 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 108091005981 phosphorylated proteins Proteins 0.000 claims 1
- 229940033515 pneumovax 23 Drugs 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 229960000380 propiolactone Drugs 0.000 claims 1
- 229940023143 protein vaccine Drugs 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 201000005404 rubella Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 201000010740 swine influenza Diseases 0.000 claims 1
- 102000035160 transmembrane proteins Human genes 0.000 claims 1
- 108091005703 transmembrane proteins Proteins 0.000 claims 1
- 201000008297 typhoid fever Diseases 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
- 229940104152 vivotif Drugs 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34871310P | 2010-05-26 | 2010-05-26 | |
| US34872810P | 2010-05-26 | 2010-05-26 | |
| US34871710P | 2010-05-26 | 2010-05-26 | |
| US61/348,717 | 2010-05-26 | ||
| US61/348,728 | 2010-05-26 | ||
| US61/348,713 | 2010-05-26 | ||
| US35863510P | 2010-06-25 | 2010-06-25 | |
| US61/358,635 | 2010-06-25 | ||
| PCT/US2011/038218 WO2011150264A2 (en) | 2010-05-26 | 2011-05-26 | Synthetic nanocarrier combination vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137068A Division JP6407208B2 (ja) | 2010-05-26 | 2016-07-11 | 合成ナノキャリア混合ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528181A JP2013528181A (ja) | 2013-07-08 |
| JP2013528181A5 true JP2013528181A5 (cg-RX-API-DMAC7.html) | 2014-07-17 |
| JP6324068B2 JP6324068B2 (ja) | 2018-05-23 |
Family
ID=45004392
Family Applications (12)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512256A Expired - Fee Related JP6324068B2 (ja) | 2010-05-26 | 2011-05-26 | 合成ナノキャリア混合ワクチン |
| JP2013512253A Active JP6324067B2 (ja) | 2010-05-26 | 2011-05-26 | 多価合成ナノキャリアワクチン |
| JP2013512250A Expired - Fee Related JP6371058B2 (ja) | 2010-05-26 | 2011-05-26 | 結合していないアジュバントを有するナノキャリア組成物 |
| JP2013512255A Expired - Fee Related JP6367554B2 (ja) | 2010-05-26 | 2011-05-26 | アジュバント化合成ナノキャリアの投与量選択 |
| JP2016137027A Pending JP2017008054A (ja) | 2010-05-26 | 2016-07-11 | 結合していないアジュバントを有するナノキャリア組成物 |
| JP2016137048A Pending JP2017008055A (ja) | 2010-05-26 | 2016-07-11 | 多価合成ナノキャリアワクチン |
| JP2016137057A Pending JP2017014216A (ja) | 2010-05-26 | 2016-07-11 | アジュバント化合成ナノキャリアの投与量選択 |
| JP2016137068A Expired - Fee Related JP6407208B2 (ja) | 2010-05-26 | 2016-07-11 | 合成ナノキャリア混合ワクチン |
| JP2017197308A Pending JP2018052937A (ja) | 2010-05-26 | 2017-10-11 | 結合していないアジュバントを有するナノキャリア組成物 |
| JP2017199990A Pending JP2018052940A (ja) | 2010-05-26 | 2017-10-16 | 多価合成ナノキャリアワクチン |
| JP2017214375A Pending JP2018065813A (ja) | 2010-05-26 | 2017-11-07 | アジュバント化合成ナノキャリアの投与量選択 |
| JP2019163782A Pending JP2020023492A (ja) | 2010-05-26 | 2019-09-09 | アジュバント化合成ナノキャリアの投与量選択 |
Family Applications After (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512253A Active JP6324067B2 (ja) | 2010-05-26 | 2011-05-26 | 多価合成ナノキャリアワクチン |
| JP2013512250A Expired - Fee Related JP6371058B2 (ja) | 2010-05-26 | 2011-05-26 | 結合していないアジュバントを有するナノキャリア組成物 |
| JP2013512255A Expired - Fee Related JP6367554B2 (ja) | 2010-05-26 | 2011-05-26 | アジュバント化合成ナノキャリアの投与量選択 |
| JP2016137027A Pending JP2017008054A (ja) | 2010-05-26 | 2016-07-11 | 結合していないアジュバントを有するナノキャリア組成物 |
| JP2016137048A Pending JP2017008055A (ja) | 2010-05-26 | 2016-07-11 | 多価合成ナノキャリアワクチン |
| JP2016137057A Pending JP2017014216A (ja) | 2010-05-26 | 2016-07-11 | アジュバント化合成ナノキャリアの投与量選択 |
| JP2016137068A Expired - Fee Related JP6407208B2 (ja) | 2010-05-26 | 2016-07-11 | 合成ナノキャリア混合ワクチン |
| JP2017197308A Pending JP2018052937A (ja) | 2010-05-26 | 2017-10-11 | 結合していないアジュバントを有するナノキャリア組成物 |
| JP2017199990A Pending JP2018052940A (ja) | 2010-05-26 | 2017-10-16 | 多価合成ナノキャリアワクチン |
| JP2017214375A Pending JP2018065813A (ja) | 2010-05-26 | 2017-11-07 | アジュバント化合成ナノキャリアの投与量選択 |
| JP2019163782A Pending JP2020023492A (ja) | 2010-05-26 | 2019-09-09 | アジュバント化合成ナノキャリアの投与量選択 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US9066978B2 (cg-RX-API-DMAC7.html) |
| EP (5) | EP2575773A4 (cg-RX-API-DMAC7.html) |
| JP (12) | JP6324068B2 (cg-RX-API-DMAC7.html) |
| KR (5) | KR20130108984A (cg-RX-API-DMAC7.html) |
| CN (10) | CN105194665A (cg-RX-API-DMAC7.html) |
| AU (8) | AU2011258156B2 (cg-RX-API-DMAC7.html) |
| BR (3) | BR112012029912A2 (cg-RX-API-DMAC7.html) |
| CA (4) | CA2798994A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2575876T3 (cg-RX-API-DMAC7.html) |
| EA (6) | EA201500857A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2661978T3 (cg-RX-API-DMAC7.html) |
| IL (6) | IL222680B (cg-RX-API-DMAC7.html) |
| MX (4) | MX355036B (cg-RX-API-DMAC7.html) |
| NO (1) | NO2575876T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2575876T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2575876T (cg-RX-API-DMAC7.html) |
| WO (4) | WO2011150258A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (157)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2804472T3 (es) | 2005-12-13 | 2021-02-08 | Harvard College | Estructuras para trasplante celular |
| AU2007303608B2 (en) | 2006-09-29 | 2013-05-02 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| WO2009002401A2 (en) | 2007-06-21 | 2008-12-31 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
| US10130696B2 (en) | 2007-09-18 | 2018-11-20 | Takeda Vaccines, Inc. | Method of conferring a protective immune response to norovirus |
| US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
| AU2009215188B2 (en) | 2008-02-13 | 2014-09-18 | Dana-Farber Cancer Institute, Inc. | Continuous cell programming devices |
| WO2009146456A1 (en) | 2008-05-30 | 2009-12-03 | President And Fellows Of Harvard College | Controlled release of growth factors and signaling molecules for promoting angiogenesis |
| CN105085349B (zh) | 2008-07-21 | 2018-02-09 | 布赖汉姆妇女医院 | 与合成的β‑1,6 葡糖胺寡糖相关的方法和组合物 |
| CN102333538B (zh) * | 2008-12-09 | 2014-01-15 | 科勒制药集团有限公司 | 免疫刺激性寡核苷酸 |
| WO2010120749A2 (en) | 2009-04-13 | 2010-10-21 | President And Fellow Of Harvard College | Harnessing cell dynamics to engineer materials |
| WO2010123569A2 (en) * | 2009-04-21 | 2010-10-28 | Selecta Biosciences, Inc. | Immunonanotherapeutics providing a th1-biased response |
| AU2010254549B2 (en) | 2009-05-27 | 2016-10-20 | Selecta Biosciences, Inc. | Nanocarriers possessing components with different rates of release |
| WO2011014871A1 (en) | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
| MX343908B (es) * | 2009-08-26 | 2016-11-28 | Selecta Biosciences Inc * | Composiciones que inducen la ayuda de las células t. |
| EP2542230A4 (en) | 2010-03-05 | 2013-08-28 | Harvard College | PROMOTING THE ADHESION OF SKELETAL MUSCLE STEM CELLS BY SIMULTANEOUS ADMINISTRATION OF VEGF AND IGF-1 |
| CN105194665A (zh) | 2010-05-26 | 2015-12-30 | 西莱克塔生物科技公司 | 具有不偶合的佐剂的纳米载体组合物 |
| US9693954B2 (en) | 2010-06-25 | 2017-07-04 | President And Fellows Of Harvard College | Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones |
| KR102157971B1 (ko) | 2010-10-06 | 2020-09-18 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 재료에 기초한 세포 치료를 위한 주사 가능한 기공 형성 하이드로겔 |
| WO2012061717A1 (en) * | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| WO2012064697A2 (en) | 2010-11-08 | 2012-05-18 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
| EP2701753B1 (en) | 2011-04-27 | 2018-12-26 | President and Fellows of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| AU2012249456A1 (en) | 2011-04-28 | 2013-10-31 | President And Fellows Of Harvard College | Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration |
| CN118078979A (zh) | 2011-04-29 | 2024-05-28 | 西莱克塔生物科技公司 | 用于降低针对治疗性蛋白的免疫应答的致耐受性合成纳米载体 |
| DK2714017T3 (en) * | 2011-06-02 | 2018-09-03 | Univ California | MEMBRANE-WRAPPED NANOPARTICLES AND METHOD OF USE |
| AU2012261848B2 (en) | 2011-06-03 | 2017-06-15 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
| EA202090699A3 (ru) * | 2011-07-11 | 2020-11-30 | Такеда Вэксинс, Инк. | Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| US20130122106A1 (en) * | 2011-10-19 | 2013-05-16 | Aphios Corporation | Dosage form, and methods of making and using the same, to produce immunization in animals and humans |
| SMT202200355T1 (it) | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| JP6293674B2 (ja) * | 2012-01-13 | 2018-03-14 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 構造化ポリマー装置におけるｔｌｒアゴニストの制御送達 |
| KR101822941B1 (ko) * | 2012-02-06 | 2018-01-29 | 엘지전자 주식회사 | 공기정화필터 및 그 제조방법 |
| EP2634179A1 (en) * | 2012-02-28 | 2013-09-04 | Sanofi | Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging |
| CN108949772A (zh) | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| WO2014018931A1 (en) * | 2012-07-26 | 2014-01-30 | The General Hospital Corporation | Methods and compositions for treating autoimmune disease |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| WO2014028537A1 (en) | 2012-08-14 | 2014-02-20 | 10X Technologies, Inc. | Microcapsule compositions and methods |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| KR101953374B1 (ko) * | 2012-09-27 | 2019-02-28 | 고려대학교 산학협력단 | 단백질 나노입자 기반의 복합백신 |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CN103083663B (zh) * | 2013-02-04 | 2014-12-10 | 江苏省农业科学院 | 一种免疫增强剂、灭活疫苗及其制备方法 |
| US10206985B2 (en) * | 2013-02-05 | 2019-02-19 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for mucosal administration |
| AU2014214682B2 (en) | 2013-02-08 | 2018-07-26 | 10X Genomics, Inc. | Polynucleotide barcode generation |
| EP2968584A1 (en) * | 2013-03-11 | 2016-01-20 | Cristal Delivery B.V. | Vaccination composition |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US10434088B2 (en) | 2013-05-03 | 2019-10-08 | Selecta Biosciences, Inc. | Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose |
| AU2014292926B2 (en) | 2013-07-25 | 2020-03-05 | Exicure Operating Company | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| CA2920631A1 (en) * | 2013-08-06 | 2015-02-12 | The Johns Hopkins University | Methods of treatment of hpv related diseases |
| CN104338126B (zh) * | 2013-08-08 | 2018-05-04 | 中国科学院过程工程研究所 | 一种具有治疗或预防hpv病毒的疫苗组合物及其应用 |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| SMT201700442T1 (it) | 2013-09-16 | 2017-11-15 | Astrazeneca Ab | Nanoparticelle polimeriche terapeutiche e metodi per preparare e usare le stesse |
| WO2015066715A1 (en) * | 2013-11-04 | 2015-05-07 | Viracell Advanced Products, Llc | Virus-like particles and methods related thereto |
| EP3092256B1 (en) | 2014-01-10 | 2022-05-18 | Birdie Biopharmaceuticals Inc. | Compounds and compositions for immunotherapy |
| EP3791863B1 (en) | 2014-01-21 | 2025-09-10 | Anjarium Biosciences AG | Process for the production of hybridosomes |
| RS66380B1 (sr) | 2014-04-23 | 2025-02-28 | Modernatx Inc | Vakcine nukleinske kiseline |
| CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
| WO2015187966A1 (en) | 2014-06-04 | 2015-12-10 | Aurasense Therapeutics, Llc | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| AU2015280417B2 (en) | 2014-06-24 | 2020-01-30 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
| EA201692512A1 (ru) | 2014-06-25 | 2017-07-31 | Селекта Байосайенсиз, Инк. | Способы и композиции для лечения синтетическими наноносителями и ингибиторами иммунной контрольной точки |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| MX2016016902A (es) | 2014-06-26 | 2017-03-27 | 10X Genomics Inc | Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas. |
| JP6760919B2 (ja) | 2014-07-09 | 2020-09-23 | バーディー バイオファーマシューティカルズ インコーポレイテッド | 腫瘍を治療するための抗ｐｄ−ｌ１組み合わせ |
| JP6836829B2 (ja) * | 2014-08-04 | 2021-03-03 | 日東電工株式会社 | 核内受容体リガンドを含む免疫誘導促進用組成物及びワクチン医薬組成物 |
| WO2016037165A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
| GB201418004D0 (en) * | 2014-10-10 | 2014-11-26 | Isis Innovation | Polymer adjuvant |
| MA40824A (fr) * | 2014-10-22 | 2017-08-29 | Saiba Gmbh | Particules de cmv de type virus modifié |
| WO2016073348A1 (en) * | 2014-11-03 | 2016-05-12 | Albert Einstein College Of Medicine, Inc. | Modified paramagnetic nanoparticles for targeted delivery of therapeutics and methods thereof |
| RU2600031C2 (ru) * | 2014-11-11 | 2016-10-20 | Публичное акционерное общество "Фармсинтез" | Лекарственная форма специфического иммунобиологического лекарственного средства для лечения и профилактики вич инфекции и способ ее получения |
| WO2016081911A2 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| US10339559B2 (en) * | 2014-12-04 | 2019-07-02 | Adobe Inc. | Associating social comments with individual assets used in a campaign |
| KR101586466B1 (ko) * | 2014-12-31 | 2016-01-18 | 성균관대학교산학협력단 | 면역보조제 및 이를 포함하는 백신 조성물 |
| EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY |
| CN107708756A (zh) | 2015-04-10 | 2018-02-16 | 哈佛学院院长等 | 免疫细胞捕获装置及其制备和使用方法 |
| KR101595949B1 (ko) * | 2015-05-27 | 2016-02-19 | 성균관대학교산학협력단 | 아주번트 조성물 및 백신 조성물의 제조 방법 |
| BE1024420B1 (fr) | 2015-06-12 | 2018-02-19 | Glaxosmithkline Biologicals Sa | Polynucleotides et polypeptides d'adenovirus |
| KR20180086180A (ko) | 2015-06-15 | 2018-07-30 | 에모리 유니버시티 | 다가 엔테로바이러스 백신 조성물 및 이와 관련된 용도 |
| WO2017004586A1 (en) * | 2015-07-02 | 2017-01-05 | Medigen, Inc. | Recombinant virus like particles using bovine immunodeficiency virus gag protein |
| US10765690B2 (en) | 2015-08-06 | 2020-09-08 | Glaxosmithkline Intellectual Property Development Limited | TLR4 agonists and compositions thereof and their use in the treatment of cancer |
| EP4349405A3 (en) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Respiratory virus vaccines |
| US11103461B2 (en) | 2015-12-22 | 2021-08-31 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CN106943597A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| US11672866B2 (en) | 2016-01-08 | 2023-06-13 | Paul N. DURFEE | Osteotropic nanoparticles for prevention or treatment of bone metastases |
| CN105535964B (zh) * | 2016-01-27 | 2019-01-18 | 苏文全 | 一种具有免疫调节作用的双链聚核苷酸—ε-聚赖氨酸—硫酸聚糖复合物及其制备使用方法 |
| CN105664152B (zh) * | 2016-01-27 | 2019-01-18 | 苏文全 | 一种具有免疫调节作用的双链聚核苷酸—ε-聚赖氨酸复合物及其制备使用方法 |
| CN115531609A (zh) | 2016-02-06 | 2022-12-30 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
| CN115404196A (zh) | 2016-07-13 | 2022-11-29 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| CA3032505A1 (en) | 2016-08-02 | 2018-02-08 | President And Fellows Of Harvard College | Biomaterials for modulating immune responses |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| PL3432916T3 (pl) | 2016-09-13 | 2020-04-30 | Allergan, Inc. | Niebiałkowo stabilzowane kompozycje toksyny clostridium |
| EP3538146A4 (en) | 2016-11-11 | 2020-07-15 | ModernaTX, Inc. | INFLUENZA VACCINE |
| CN106496309A (zh) * | 2016-11-24 | 2017-03-15 | 北京开景基因技术有限公司 | 微球抗原及其制备方法以及抗可替宁抗体的制备方法 |
| KR101996538B1 (ko) * | 2017-02-13 | 2019-07-04 | 단디바이오사이언스 주식회사 | 이미다조퀴놀린계열 물질을 포함하는 나노에멀젼 및 이의 용도 |
| US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
| CN106943592A (zh) * | 2017-03-02 | 2017-07-14 | 暨南大学 | 磷酸化壳聚糖作为免疫佐剂在疫苗治疗中的应用 |
| CA3055936A1 (en) | 2017-03-11 | 2018-09-20 | Selecta Biosciences, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| IL302880A (en) | 2017-04-04 | 2023-07-01 | Avidea Tech Inc | Peptide-based ingredients, production methods, and their uses for inducing an immune response |
| US20210283248A1 (en) * | 2017-04-25 | 2021-09-16 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| CN118515666A (zh) | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| WO2018201090A1 (en) | 2017-04-28 | 2018-11-01 | Exicure, Inc. | Synthesis of spherical nucleic acids using lipophilic moieties |
| US11517567B2 (en) | 2017-06-23 | 2022-12-06 | Birdie Biopharmaceuticals, Inc. | Pharmaceutical compositions |
| NL2019373B1 (en) * | 2017-07-28 | 2019-02-19 | Academisch Ziekenhuis Leiden | Enhancement of pathogen immunogenicity |
| US20200375912A1 (en) * | 2017-08-03 | 2020-12-03 | Rita Elena Serda | Liposomal coated nanoparticles for immunotherapy applications |
| US11123415B2 (en) | 2017-08-16 | 2021-09-21 | Ohio State Innovation Foundation | Nanoparticle compositions for Salmonella vaccines |
| WO2019055539A1 (en) | 2017-09-12 | 2019-03-21 | Prudhomme Robert K | CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME |
| CN107582564A (zh) * | 2017-09-14 | 2018-01-16 | 湖南晓林生物科技发展有限公司 | 一种靶向治疗甲状腺癌的药物及其制备方法 |
| US10837047B2 (en) * | 2017-10-04 | 2020-11-17 | 10X Genomics, Inc. | Compositions, methods, and systems for bead formation using improved polymers |
| CN111386134B (zh) * | 2017-10-04 | 2023-11-03 | 10X基因组学有限公司 | 使用改进的聚合物形成珠的组合物、方法和系统 |
| US10590244B2 (en) * | 2017-10-04 | 2020-03-17 | 10X Genomics, Inc. | Compositions, methods, and systems for bead formation using improved polymers |
| US20200330581A1 (en) * | 2017-10-09 | 2020-10-22 | Keith Black | Oncolytic cancer immunotherapies and methods of use |
| EP3703667A4 (en) | 2017-11-03 | 2021-08-04 | The Trustees of Princeton University | PAIRING OF HYDROPHOBIC IONS AND FLASH NANOPRECIPITATION FOR FORMULATIONS OF CONTROLLED RELEASE NANOVECTORS |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| US20200306364A1 (en) * | 2017-11-30 | 2020-10-01 | Ohio State Innovation Foundation | Mucoadhesive nanoparticle entrapped influenza virus vaccine delivery system |
| CN108379562B (zh) * | 2018-03-20 | 2021-11-12 | 苏州杰纳生物科技有限公司 | 一种聚合物纳米佐剂及其制备方法和用途 |
| CN112020823B (zh) | 2018-05-10 | 2024-07-19 | 日产自动车株式会社 | 电机系统的控制方法以及电机系统的控制装置 |
| EA038215B1 (ru) * | 2018-06-09 | 2021-07-26 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр исследований и разработки иммунобиологических препаратов им. М.П. Чумакова РАН" | Способ количественного определения антигена вируса желтой лихорадки иммуноферментным анализом с использованием специфических желточных антител и детекторных антител, меченных биотином |
| US12186436B2 (en) | 2018-07-19 | 2025-01-07 | The Trustees Of Princeton University | Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents |
| US11731099B2 (en) | 2018-07-20 | 2023-08-22 | The Trustees Of Princeton University | Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation |
| CN109187982B (zh) * | 2018-08-02 | 2021-06-04 | 浙江康佰裕生物科技有限公司 | 一种tlr类疫苗佐剂的筛选和鉴定方法 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| US12252708B2 (en) | 2018-09-24 | 2025-03-18 | Unm Rainforest Innovations | Living mammalian cells modified with functional modular nanoparticles |
| US12397014B2 (en) * | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| US12208164B2 (en) | 2019-02-28 | 2025-01-28 | Unm Rainforest Innovations | Modular metal-organic polyhedra superassembly compositions |
| BR112021021637A2 (pt) | 2019-05-20 | 2021-12-21 | Valneva Se | Vacina de subunidade para tratamento ou prevenção de uma infecção do trato respiratório |
| CN110559432B (zh) * | 2019-10-11 | 2023-06-13 | 南京农业大学 | 一种堆型艾美耳球虫纳米亚单位疫苗及其制备方法和应用 |
| JP2021127868A (ja) | 2020-02-14 | 2021-09-02 | 株式会社デンソー | 熱交換器 |
| US11559578B2 (en) | 2020-06-30 | 2023-01-24 | International Business Machines Corporation | Biodegradable cationic polycarbonates as adjuvants for vaccines |
| WO2022031011A1 (ko) * | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | 동력학적으로 작용하는 아주번트 앙상블 |
| WO2022040564A1 (en) * | 2020-08-21 | 2022-02-24 | University Of Iowa Research Foundation | Cationic nanoparticle adjuvants |
| CN116917470A (zh) | 2020-10-14 | 2023-10-20 | 达冕生物有限公司 | PAN-RAS mRNA癌症疫苗 |
| KR102769964B1 (ko) * | 2020-10-26 | 2025-02-19 | 한국과학기술원 | Bp26 및 항원 폴리펩타이드를 포함하는 융합 단백질 |
| WO2022109484A1 (en) * | 2020-11-23 | 2022-05-27 | Wisconsin Alumni Research Foundation | Neutralizing vaccines against human coronavirus |
| US12329811B2 (en) | 2021-01-11 | 2025-06-17 | Modernatx, Inc. | Seasonal RNA influenza virus vaccines |
| CN112972673B (zh) * | 2021-02-02 | 2023-04-11 | 兰州大学 | PLGA-PEG-Poly I：C纳米颗粒的制备及其在结核亚单位疫苗中的应用 |
| US20240207394A1 (en) * | 2021-04-21 | 2024-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Toll-like receptor agonist-nanoparticle vaccine adjuvant |
| WO2023024500A1 (en) | 2021-08-27 | 2023-03-02 | Peking University | Constructs and methods for preparing circular rna |
| EP4397315A4 (en) * | 2021-08-30 | 2025-09-24 | Toray Industries | COMPOSITION TO IMPROVE IMMUNOGENICITY |
| US20240366739A1 (en) * | 2021-09-16 | 2024-11-07 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
| AU2022404969A1 (en) * | 2021-12-06 | 2024-05-16 | SURGE Therapeutics, Inc. | Solid forms of resiquimod and formulations thereof |
| JP2025508467A (ja) | 2022-02-24 | 2025-03-26 | アイオー バイオテック エーピーエス | 癌治療のヌクレオチド送達 |
| US20230202978A1 (en) | 2022-03-04 | 2023-06-29 | Reset Pharmaceuticals, Inc. | Co-crystal or salt |
| JP2025517396A (ja) * | 2022-05-16 | 2025-06-05 | デイリー マネジメント インク． | 活性剤を含むタンパク質粒子、並びにその製造方法及び使用方法 |
| KR20230002334U (ko) | 2022-06-02 | 2023-12-11 | 성기봉 | 일회용 얼음팩 |
| CN115300619B (zh) * | 2022-06-30 | 2025-03-21 | 江汉大学 | 基于人乳头瘤病毒l2蛋白的宫颈癌广谱疫苗及其制备方法 |
| CN115645523B (zh) * | 2022-12-22 | 2023-03-21 | 深圳大学总医院 | 聚合物脂质杂化纳米粒作为免疫佐剂的应用以及一种免疫制剂 |
| CN116478410B (zh) * | 2023-06-20 | 2023-09-12 | 觅投克(北京)生物医学技术有限公司 | 一种菊糖修饰的聚乙烯亚胺衍生物及其制备方法和应用 |
| EP4520345A1 (en) | 2023-09-06 | 2025-03-12 | Myneo Nv | Product |
| CN117512031B (zh) * | 2023-10-16 | 2024-06-25 | 江苏金迪克生物技术股份有限公司 | 一种肺炎球菌荚膜多糖的纯化方法 |
| CN120795181B (zh) * | 2025-09-15 | 2025-11-21 | 吉林大学 | 一种用于抗布鲁氏菌抗体检测的l7/l12-padre序列-多联b细胞表位重组蛋白及试剂盒 |
Family Cites Families (368)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7461M (cg-RX-API-DMAC7.html) | 1968-06-19 | 1970-01-05 | ||
| GB1355961A (en) | 1970-02-27 | 1974-06-12 | Wellcome Found | Preparation of immunosuppressive antilymphocytic serum |
| CH594444A5 (cg-RX-API-DMAC7.html) | 1972-12-04 | 1978-01-13 | Gerd Birrenbach | |
| US3996355A (en) | 1975-01-02 | 1976-12-07 | American Home Products Corporation | Permanent suspension pharmaceutical dosage form |
| DK143689C (da) | 1975-03-20 | 1982-03-15 | J Kreuter | Fremgangsmaade til fremstilling af en adsorberet vaccine |
| US4756907A (en) | 1978-10-17 | 1988-07-12 | Stolle Research & Development Corp. | Active/passive immunization of the internal female reproductive organs |
| US4946929A (en) | 1983-03-22 | 1990-08-07 | Massachusetts Institute Of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
| US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US4806621A (en) | 1986-01-21 | 1989-02-21 | Massachusetts Institute Of Technology | Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article |
| JPS63122620A (ja) | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
| CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| US5759830A (en) | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
| US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
| FR2608988B1 (fr) | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
| US5912017A (en) | 1987-05-01 | 1999-06-15 | Massachusetts Institute Of Technology | Multiwall polymeric microspheres |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| US5019379A (en) | 1987-07-31 | 1991-05-28 | Massachusetts Institute Of Technology | Unsaturated polyanhydrides |
| US4950432A (en) | 1987-10-16 | 1990-08-21 | Board Of Regents, The University Of Texas System | Polyene microlide pre-liposomal powders |
| US6130082A (en) | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| US4929624A (en) | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| US5010167A (en) | 1989-03-31 | 1991-04-23 | Massachusetts Institute Of Technology | Poly(amide-and imide-co-anhydride) for biological application |
| US5114703A (en) | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US6005087A (en) | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US6399754B1 (en) | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
| GB9016885D0 (en) | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
| US6699474B1 (en) | 1990-08-20 | 2004-03-02 | Erich Hugo Cerny | Vaccine and immunserum against drugs of abuse |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5175296A (en) | 1991-03-01 | 1992-12-29 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-c]quinolin-4-amines and processes for their preparation |
| SG46492A1 (en) | 1991-03-01 | 1998-02-20 | Minnesota Mining & Mfg | 1-Substituted 2-substituted 1H-imidazo [4,5-c] quinolin-4-amines |
| NZ242220A (en) | 1991-04-02 | 1994-04-27 | Biotech Australia Pty Ltd | Complex for oral delivery of a substance to the circulatory or lymphatic drainage system comprising microparticle coupled to at least one carrier, the substance being encapsulated by the microparticle |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| IL105325A (en) | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
| US6235313B1 (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| SK279188B6 (sk) | 1992-06-25 | 1998-07-08 | Smithkline Beecham Biologicals S.A. | Vakcínová kompozícia spôsob jej prípravy a použiti |
| JPH07509467A (ja) | 1992-07-21 | 1995-10-19 | ザ ゼネラル ホスピタル コーポレーション | リンパ組織への薬物輸送システム |
| GB9216082D0 (en) | 1992-07-28 | 1992-09-09 | Univ Nottingham | Lymphatic delivery composition |
| US6608201B2 (en) | 1992-08-28 | 2003-08-19 | 3M Innovative Properties Company | Process for preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| AU4932493A (en) | 1992-09-25 | 1994-04-26 | Dynagen, Inc. | An immunobooster for delayed release of immunogen |
| US5399665A (en) | 1992-11-05 | 1995-03-21 | Massachusetts Institute Of Technology | Biodegradable polymers for cell transplantation |
| CA2153391C (en) | 1993-01-11 | 2000-08-15 | Kenneth Rock | Inducing cytotoxic t lymphocyte responses |
| US5512600A (en) | 1993-01-15 | 1996-04-30 | Massachusetts Institute Of Technology | Preparation of bonded fiber structures for cell implantation |
| US5395937A (en) | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
| US5514378A (en) | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
| DE69411154T2 (de) | 1993-02-22 | 1998-10-22 | Alza Corp., Palo Alto, Calif. | Mittel zur oralen gabe von wirkstoffen |
| WO1994021240A2 (de) | 1993-03-17 | 1994-09-29 | Silica Gel Ges.M.B.H | Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben |
| CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| WO1995003035A1 (en) | 1993-07-23 | 1995-02-02 | Massachusetts Institute Of Technology | Polymerized liposomes with enhanced stability for oral delivery |
| WO1995007707A1 (en) | 1993-09-14 | 1995-03-23 | Cytel Corporation | Alteration of immune response using pan dr-binding peptides |
| US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5500161A (en) | 1993-09-21 | 1996-03-19 | Massachusetts Institute Of Technology And Virus Research Institute | Method for making hydrophobic polymeric microparticles |
| WO1995022963A1 (en) | 1994-02-28 | 1995-08-31 | Medinova Medical Consulting Gmbh | Drug targeting system, method for preparing same and its use |
| US5596091A (en) | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| GB9412273D0 (en) | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| CA2560114A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US5716404A (en) | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
| AU4755696A (en) | 1995-01-05 | 1996-07-24 | Board Of Regents Acting For And On Behalf Of The University Of Michigan, The | Surface-modified nanoparticles and method of making and using same |
| US5876727A (en) | 1995-03-31 | 1999-03-02 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| US6123727A (en) | 1995-05-01 | 2000-09-26 | Massachusetts Institute Of Technology | Tissue engineered tendons and ligaments |
| US5866132A (en) | 1995-06-07 | 1999-02-02 | Alberta Research Council | Immunogenic oligosaccharide compositions |
| WO1997004747A1 (en) | 1995-07-27 | 1997-02-13 | Dunn James M | Drug delivery systems for macromolecular drugs |
| CA2230494A1 (en) | 1995-08-31 | 1997-03-06 | Alkermes Controlled Therapeutics Inc. | Composition for sustained release of an agent |
| US6095148A (en) | 1995-11-03 | 2000-08-01 | Children's Medical Center Corporation | Neuronal stimulation using electrically conducting polymers |
| US5902599A (en) | 1996-02-20 | 1999-05-11 | Massachusetts Institute Of Technology | Biodegradable polymer networks for use in orthopedic and dental applications |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| WO1997047623A1 (en) | 1996-06-10 | 1997-12-18 | Cytos Pharmaceuticals Llc | Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses |
| US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| ES2188985T3 (es) | 1996-08-30 | 2003-07-01 | Jens Peter Furste | Seleccion enantiomerica y evolucion enantiomerica de acidos nucleicos. |
| US6043224A (en) | 1996-09-05 | 2000-03-28 | The Massachusetts Institute Of Technology | Compositions and methods for treatment of neurological disorders and neurodegenerative diseases |
| EP0938315B9 (en) | 1996-10-25 | 2008-02-20 | Minnesota Mining And Manufacturing Company | Immune response modifier compounds for treatment of th2 mediated and related diseases |
| US6042820A (en) | 1996-12-20 | 2000-03-28 | Connaught Laboratories Limited | Biodegradable copolymer containing α-hydroxy acid and α-amino acid units |
| US6127533A (en) | 1997-02-14 | 2000-10-03 | Isis Pharmaceuticals, Inc. | 2'-O-aminooxy-modified oligonucleotides |
| CA2281838A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated cpg dinucleotide in the treatment of lps-associated disorders |
| DE69841122D1 (de) | 1997-03-10 | 2009-10-15 | Coley Pharm Gmbh | Verwendung von nicht-methyliertem CpG Dinukleotid in Kombination mit Aluminium als Adjuvantien |
| US5989591A (en) | 1997-03-14 | 1999-11-23 | American Home Products Corporation | Rapamycin formulations for oral administration |
| US6211159B1 (en) | 1997-04-11 | 2001-04-03 | University Of Toronto | Flagellin gene, FlaC of campylobacter |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| US5985325A (en) | 1997-06-13 | 1999-11-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
| US5837752A (en) | 1997-07-17 | 1998-11-17 | Massachusetts Institute Of Technology | Semi-interpenetrating polymer networks |
| US6989435B2 (en) | 1997-09-11 | 2006-01-24 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| DE19745950A1 (de) | 1997-10-17 | 1999-04-22 | Dds Drug Delivery Service Ges | Arzneistoffträgerpartikel für die gewebespezifische Arzneistoffapplikation |
| DE69817393T2 (de) | 1997-11-28 | 2004-06-17 | Sumitomo Pharmaceuticals Co., Ltd. | Neue heterozyklische verbindungen |
| US6197229B1 (en) | 1997-12-12 | 2001-03-06 | Massachusetts Institute Of Technology | Method for high supercoiled DNA content microspheres |
| US6254890B1 (en) | 1997-12-12 | 2001-07-03 | Massachusetts Institute Of Technology | Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| FR2775435B1 (fr) | 1998-02-27 | 2000-05-26 | Bioalliance Pharma | Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs |
| KR20010041629A (ko) * | 1998-03-09 | 2001-05-25 | 장 스테판느 | 혼합 백신 조성물 |
| US6232287B1 (en) | 1998-03-13 | 2001-05-15 | The Burnham Institute | Molecules that home to various selected organs or tissues |
| US6632922B1 (en) | 1998-03-19 | 2003-10-14 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
| US6506577B1 (en) | 1998-03-19 | 2003-01-14 | The Regents Of The University Of California | Synthesis and crosslinking of catechol containing copolypeptides |
| US6686446B2 (en) | 1998-03-19 | 2004-02-03 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
| EP1067956B1 (en) | 1998-04-03 | 2007-03-14 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| EP1077708A1 (en) | 1998-05-06 | 2001-02-28 | University Of Iowa Research Foundation | Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides |
| SE9801923D0 (sv) | 1998-05-29 | 1998-05-29 | Independent Pharmaceutical Ab | Nicotine vaccine |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| US6242589B1 (en) | 1998-07-14 | 2001-06-05 | Isis Pharmaceuticals, Inc. | Phosphorothioate oligonucleotides having modified internucleoside linkages |
| ATE321535T1 (de) | 1998-07-29 | 2006-04-15 | Chiron Corp | Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung |
| DE19839214C1 (de) | 1998-08-28 | 2000-05-25 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von sphärischen Mikropartikeln mit glatter Oberfläche, die ganz oder teilweise aus mindestens einem wasserunlöslichen linearen Polysaccharid bestehen, sowie mit diesem Verfahren erhältliche Mikropartikel und deren Verwendung |
| US6306640B1 (en) | 1998-10-05 | 2001-10-23 | Genzyme Corporation | Melanoma antigenic peptides |
| JP2002526419A (ja) | 1998-10-05 | 2002-08-20 | ファーメクサ エイ／エス | 治療上のワクチン注射のための新規な方法 |
| DK1126876T3 (da) | 1998-10-16 | 2007-07-02 | Glaxosmithkline Biolog Sa | Adjuvanssystemer og vacciner |
| PL205109B1 (pl) | 1998-11-02 | 2010-03-31 | Elan Pharma Int Ltd | Wielocząstkowa kompozycja metylofenidatu o modyfikowanym uwalnianiu i jej zastosowanie |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| US6232082B1 (en) | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| US6403779B1 (en) | 1999-01-08 | 2002-06-11 | Isis Pharmaceuticals, Inc. | Regioselective synthesis of 2′-O-modified nucleosides |
| WO2000040228A2 (en) | 1999-01-08 | 2000-07-13 | 3M Innovative Properties Company | Formulations comprising imiquimod or other immune response modifiers for treating mucosal conditions |
| US6486168B1 (en) | 1999-01-08 | 2002-11-26 | 3M Innovative Properties Company | Formulations and methods for treatment of mucosal associated conditions with an immune response modifier |
| US7238711B1 (en) | 1999-03-17 | 2007-07-03 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6444192B1 (en) | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
| US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| DE60015084T2 (de) | 1999-02-26 | 2006-02-16 | Chiron S.R.L. | Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden |
| US6110462A (en) | 1999-03-03 | 2000-08-29 | The Scripps Research Institute | Enzymatic DNA molecules that contain modified nucleotides |
| DK1187629T3 (da) | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| US6800296B1 (en) | 1999-05-19 | 2004-10-05 | Massachusetts Institute Of Technology | Modification of surfaces using biological recognition events |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6815170B1 (en) | 1999-06-30 | 2004-11-09 | John Wayne Cancer Institute | Methods for lymph node identification |
| WO2001012071A1 (en) | 1999-08-13 | 2001-02-22 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents and for lymphatic system |
| WO2001022972A2 (en) | 1999-09-25 | 2001-04-05 | University Of Iowa Research Foundation | Immunostimulatory nucleic acids |
| ATE420657T1 (de) | 1999-10-12 | 2009-01-15 | Ca Nat Research Council | Archaeosome als adjuvantien und träger für azelluläre impstoffe zur induktion einer zytotoxischen t-lymphozyten (ctl) immunantwort |
| CA2391534A1 (en) | 1999-11-15 | 2001-05-25 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
| US7223398B1 (en) | 1999-11-15 | 2007-05-29 | Dynavax Technologies Corporation | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof |
| EP1294930B1 (en) | 2000-01-13 | 2011-03-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| US20050020525A1 (en) | 2002-02-20 | 2005-01-27 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US20050032733A1 (en) | 2001-05-18 | 2005-02-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
| US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| JP4751556B2 (ja) | 2000-02-28 | 2011-08-17 | ジーンシーグス， インコーポレイテッド | ナノカプセルカプセル化システムおよび方法 |
| US7129222B2 (en) | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| US7157437B2 (en) | 2000-03-10 | 2007-01-02 | Dynavax Technologies Corporation | Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences |
| SE0000933D0 (sv) | 2000-03-21 | 2000-03-21 | Independent Pharmaceutica Ab | Method of producing 6-substituted (S)-nicotine derivatives and intermediate compounds |
| DE60140676D1 (de) | 2000-03-30 | 2010-01-14 | Massachusetts Inst Technology | Mediatoren von rns-interferenz, die rns-sequenzspezifisch sind |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| US7192725B2 (en) | 2000-05-19 | 2007-03-20 | University Of Toronto | Flagellin gene, flaC of Campylobacter |
| US6610713B2 (en) | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| JP2004509970A (ja) | 2000-09-26 | 2004-04-02 | ハイブリドン・インコーポレイテッド | 位置的化学変化による免疫刺激オリゴヌクレオチドアナログの免疫刺激活性の調節 |
| AU2001297913A1 (en) | 2000-10-13 | 2002-12-23 | Ligocyte Pharmaceuticals, Inc. | Polyvalent nanoparticles |
| GB0025414D0 (en) | 2000-10-16 | 2000-11-29 | Consejo Superior Investigacion | Nanoparticles |
| AU2002244337B2 (en) | 2000-10-18 | 2005-08-11 | Glaxosmithkline Biologicals S.A. | Vaccines |
| AU2002245205B2 (en) | 2000-10-19 | 2007-07-19 | Ecole Polytechnique Federale De Lausanne | Block copolymers for multifunctional self-assembled systems |
| US7592008B2 (en) | 2000-11-20 | 2009-09-22 | The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois | Membrane scaffold proteins |
| CZ308053B6 (cs) | 2000-12-01 | 2019-11-27 | Max Planck Gesellschaft | Izolovaná molekula dvouřetězcové RNA, způsob její výroby a její použití |
| WO2006091720A2 (en) | 2000-12-08 | 2006-08-31 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
| JP4188687B2 (ja) | 2000-12-27 | 2008-11-26 | ダイナバックス テクノロジーズ コーポレイション | 免疫変調ポリヌクレオチド及びその使用法 |
| US7097837B2 (en) | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| WO2004030608A2 (en) | 2001-06-05 | 2004-04-15 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| DK1264603T3 (da) | 2001-06-10 | 2010-04-26 | Noxxon Pharma Ag | Anvendelse af L-polynukleotider til in vivo-billeddannelse |
| NZ530315A (en) | 2001-07-10 | 2007-01-26 | Corixa Corp | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| JP4607452B2 (ja) | 2001-08-07 | 2011-01-05 | ダイナバックス テクノロジーズ コーポレイション | 免疫調節性組成物、製剤およびその使用方法 |
| US6818732B2 (en) | 2001-08-30 | 2004-11-16 | The Regents Of The University Of California | Transition metal initiators for controlled poly (beta-peptide) synthesis from beta-lactam monomers |
| US20030054042A1 (en) | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
| US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| US7037523B2 (en) | 2001-11-02 | 2006-05-02 | Wockhardt Limited | Controlled release compositions for macrolide antimicrobial agents |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| CA2476626A1 (en) | 2002-02-20 | 2003-08-28 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
| US20030232013A1 (en) | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
| IL164354A0 (en) | 2002-04-04 | 2005-12-18 | Coley Pharm Gmbh | Immunostimulatory g,u-containing oligoribonucleotides |
| US20040038303A1 (en) | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US20080233181A1 (en) | 2002-04-12 | 2008-09-25 | Nagy Jon O | Nanoparticle adjuvants for sub-unit vaccines |
| US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| ATE394674T1 (de) | 2002-04-22 | 2008-05-15 | Univ Florida | Funktionalisierte nanopartikel und verwendungsverfahren |
| US6824338B2 (en) * | 2002-05-28 | 2004-11-30 | Satco, Inc. | Air transport modular container system |
| US20040092470A1 (en) | 2002-06-18 | 2004-05-13 | Leonard Sherry A. | Dry powder oligonucleotide formualtion, preparation and its uses |
| US20040142887A1 (en) | 2002-07-10 | 2004-07-22 | Chengji Cui | Antigen-polymer compositions |
| NZ537003A (en) | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| CA2495570C (en) | 2002-08-15 | 2012-12-04 | 3M Innovative Properties Company | Immunostimulatory compositions and methods of stimulating an immune response |
| US20040091503A1 (en) * | 2002-08-20 | 2004-05-13 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
| US7488792B2 (en) | 2002-08-28 | 2009-02-10 | Burnham Institute For Medical Research | Collagen-binding molecules that selectively home to tumor vasculature and methods of using same |
| WO2004022594A2 (en) | 2002-09-06 | 2004-03-18 | Cytos Biotechnology Ag | Immune modulatory compounds and methods |
| US20060189554A1 (en) | 2002-09-24 | 2006-08-24 | Russell Mumper | Nanoparticle-Based vaccine delivery system containing adjuvant |
| US7008411B1 (en) | 2002-09-30 | 2006-03-07 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for treating vulnerable plaque |
| NO20024755D0 (no) | 2002-10-03 | 2002-10-03 | Amersham Health As | Metode |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| WO2004053104A2 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5’ cpg nucleic acids and methods of use |
| SE0203687D0 (sv) | 2002-12-13 | 2002-12-13 | Ian Harwigsson Med Adagit Fa | Pharmaceutical Porous Particles |
| KR101178816B1 (ko) | 2002-12-23 | 2012-09-07 | 다이나박스 테크놀로지 코퍼레이션 | 면역자극성 서열 올리고뉴클레오타이드 및 이의 이용방법 |
| CA2511538C (en) | 2002-12-30 | 2013-11-26 | 3M Innovative Properties Company | Immunostimulatory combinations |
| US20040156846A1 (en) | 2003-02-06 | 2004-08-12 | Triton Biosystems, Inc. | Therapy via targeted delivery of nanoscale particles using L6 antibodies |
| EP1592302A4 (en) | 2003-02-13 | 2007-04-25 | 3M Innovative Properties Co | METHODS AND COMPOSITIONS ASSOCIATED WITH IMMUNE RESPONSE MODIFIER COMPOUNDS AND TOLL-LIKE RECEPTOR 8 |
| US8575110B2 (en) | 2003-02-17 | 2013-11-05 | Alpha-O Peptides G | Peptidic nanoparticles as drug delivery and antigen display systems |
| ZA200507235B (en) * | 2003-03-21 | 2007-03-28 | Wyeth Corp | Treating immunological disorders using agonists of interleukin-21/interleukin-21 receptor |
| US20040191215A1 (en) | 2003-03-25 | 2004-09-30 | Michael Froix | Compositions for induction of a therapeutic response |
| EP1605972A2 (en) | 2003-03-26 | 2005-12-21 | Cytos Biotechnology AG | Hiv-peptide-carrier-conjugates |
| US20060233883A1 (en) | 2003-03-26 | 2006-10-19 | Tsutomu Ishihara | Intravenous nanoparticles for targeting drug delivery and sustained drug release |
| US20040202720A1 (en) | 2003-04-10 | 2004-10-14 | 3M Innovative Properties Company | Delivery of immune response modifier compounds using metal-containing particulate support materials |
| US7731967B2 (en) * | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| PL1631264T5 (pl) * | 2003-06-02 | 2018-09-28 | Glaxosmithkline Biologicals Sa | Kompozycje immunogenne oparte na biodegradowalnych mikrocząstkach zawierających toksoid błonicy i tężca |
| US7727969B2 (en) | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| US7149574B2 (en) | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
| US20060182793A1 (en) | 2003-07-22 | 2006-08-17 | Cytos Biotechnology Ag | Cpg-packaged liposomes |
| US20050042298A1 (en) | 2003-08-20 | 2005-02-24 | Pardridge William M. | Immunonanoparticles |
| CA2537900A1 (en) * | 2003-09-03 | 2005-04-28 | Dendritherapeutics, Inc. | Multiplex vaccines |
| US7943179B2 (en) | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
| US7771726B2 (en) | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
| US20080160089A1 (en) * | 2003-10-14 | 2008-07-03 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| US7829119B2 (en) | 2003-10-20 | 2010-11-09 | William Marsh Rice University | Method to fabricate microcapsules from polymers and charged nanoparticles |
| CN1608675A (zh) * | 2003-10-22 | 2005-04-27 | 四川大学 | 一种新型高分子材料载药纳米粒及制法和用途 |
| UA88457C2 (ru) | 2003-10-30 | 2009-10-26 | Коли Фармасьютикал Гмбх | Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью |
| EP1691780A2 (en) | 2003-11-21 | 2006-08-23 | Alza Corporation | Gene delivery mediated by liposome-dna complex with cleavable peg surface modification |
| CN1544638A (zh) * | 2003-11-28 | 2004-11-10 | 中国药科大学 | 可载荷多肽的病毒样颗粒 |
| WO2005055949A2 (en) | 2003-12-09 | 2005-06-23 | The Children's Hospital Of Philadelphia | Sustained release preparations composed of biocompatible complex microparticles |
| KR100581967B1 (ko) | 2003-12-18 | 2006-05-22 | 한국유나이티드제약 주식회사 | 소화성 궤양 치료를 위한 프로톤펌프 저해제와클래리스로마이신을 함유하는 이중 펠렛 제제 및 그의제조방법 |
| US9040090B2 (en) | 2003-12-19 | 2015-05-26 | The University Of North Carolina At Chapel Hill | Isolated and fixed micro and nano structures and methods thereof |
| KR20120105062A (ko) | 2003-12-19 | 2012-09-24 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 소프트 또는 임프린트 리소그래피를 이용하여 분리된 마이크로- 및 나노- 구조를 제작하는 방법 |
| FR2863890B1 (fr) * | 2003-12-19 | 2006-03-24 | Aventis Pasteur | Composition immunostimulante |
| EP1550458A1 (en) * | 2003-12-23 | 2005-07-06 | Vectron Therapeutics AG | Synergistic liposomal adjuvants |
| US20050191294A1 (en) | 2003-12-31 | 2005-09-01 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy |
| US20070087986A1 (en) | 2004-01-26 | 2007-04-19 | Brett Premack | Compositions and methods for enhancing immunity by chemoattractant adjuvants |
| EP2415481A3 (en) | 2004-02-19 | 2012-04-18 | Coley Pharmaceutical Group, Inc. | Immunostimulatory viral RNA oligonucleotides |
| EP1735010A4 (en) | 2004-04-09 | 2008-08-27 | 3M Innovative Properties Co | METHODS, COMPOSITIONS AND PREPARATIONS FOR ADMINISTRATION OF IMMUNE RESPONSE MODIFIERS (MRI) |
| EP1768998A2 (en) | 2004-04-27 | 2007-04-04 | Alnylam Pharmaceuticals Inc. | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety |
| ES2246695B1 (es) | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
| DK1767216T3 (da) | 2004-06-11 | 2012-09-03 | Riken | Lægemiddel med regulatorisk celleligand indeholdt i liposom |
| GB0413868D0 (en) * | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| EP1768692B8 (en) | 2004-07-01 | 2015-06-17 | Yale University | Targeted and high density drug loaded polymeric materials |
| WO2006014579A2 (en) | 2004-07-08 | 2006-02-09 | The Regents Of California | Enhancing class i antigen presentation with synthetic sequences |
| US8017151B2 (en) | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
| EP1797091A2 (en) | 2004-09-14 | 2007-06-20 | Novartis Vaccines and Diagnostics, Inc. | Imidazoquinoline compounds |
| CN1692943A (zh) | 2004-09-17 | 2005-11-09 | 四川大学 | CpG DNA分子抗感染免疫制剂的制备和应用 |
| EP1793863B1 (en) | 2004-10-01 | 2017-04-12 | Midatech Ltd. | Nanoparticles comprising antigens and adjuvants capable of stimulating t helper cells |
| US20090004118A1 (en) | 2004-10-07 | 2009-01-01 | Shuming Nie | Multifunctional Nanoparticle Conjugates And Their Use |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US9789171B2 (en) | 2004-11-05 | 2017-10-17 | The General Hospital Corporation | Anti-fugetactic agents for the treatment of ovarian cancer |
| ES2434029T3 (es) | 2004-11-15 | 2013-12-13 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido |
| US20060111271A1 (en) | 2004-11-24 | 2006-05-25 | Cerny Erich H | Active and passive immunization against pharmacologically active hapten molecules using a synthetic carrier compound composed of similar elements |
| US20070292386A9 (en) | 2004-12-02 | 2007-12-20 | Campbell Robert L | Vaccine formulations for intradermal delivery comprising adjuvants and antigenic agents |
| ATE544774T1 (de) | 2004-12-14 | 2012-02-15 | Alnylam Pharmaceuticals Inc | Rnai-modulation von mll-af4 und verwendungen dafür |
| US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
| CN101189339A (zh) | 2005-03-22 | 2008-05-28 | 美得思达健康有限公司 | 诊断和治疗心血管疾病的递送系统和方法 |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US20080305161A1 (en) | 2005-04-13 | 2008-12-11 | Pfizer Inc | Injectable depot formulations and methods for providing sustained release of nanoparticle compositions |
| US20060241076A1 (en) | 2005-04-26 | 2006-10-26 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhanced immunostimulatory activity |
| WO2006117217A2 (de) | 2005-05-04 | 2006-11-09 | Noxxon Pharma Ag | Neue verwendung von spiegelmeren |
| EP1893661B1 (en) | 2005-05-10 | 2012-01-18 | Emory University | Strategies for delivery of active agents using micelles and particles |
| US9290617B2 (en) | 2005-07-06 | 2016-03-22 | Molly S. Shoichet | Method of biomolecule immobilization on polymers using click-type chemistry |
| ES2556974T3 (es) | 2005-08-12 | 2016-01-21 | Jiang Liu | Dispositivos para la orientación al sistema linfático |
| TWI404537B (zh) | 2005-08-19 | 2013-08-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯 |
| ES2577514T3 (es) | 2005-08-22 | 2016-07-15 | The Regents Of The University Of California | Antagonistas de TLR |
| JP2009507049A (ja) | 2005-09-09 | 2009-02-19 | 北京徳科瑞医薬科技有限公司 | リン脂質のポリエチレングリコール誘導体に包み込まれたビンカアルカロイド系制癌剤のナノミセル製剤 |
| EP2883957A1 (en) | 2005-11-25 | 2015-06-17 | Zoetis Belgium S.A. | Immunostimmulatory oligoribonucleotides |
| EP1963308A4 (en) | 2005-11-28 | 2010-12-15 | Nabi Biopharmaceuticals | METHOD FOR PRODUCING A NICOTINE HAPTEN |
| ES2564241T3 (es) | 2005-12-02 | 2016-03-21 | Glaxosmithkline Biologicals Sa | Nanopartículas para su uso en composiciones inmunogénicas |
| US20070184068A1 (en) | 2005-12-14 | 2007-08-09 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
| DE602007002905D1 (de) | 2006-01-23 | 2009-12-03 | Yissum Res Dev Co | Mikrokügelchen mit nanokapseln, die ein lipophiles arzneimittel enthalten |
| WO2007089870A2 (en) | 2006-01-31 | 2007-08-09 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| ES2672625T3 (es) | 2006-02-10 | 2018-06-15 | Biocompatibles Uk Limited | Carga de fármacos hidrófobos en sistemas de suministro poliméricos hidrófilos |
| US8021689B2 (en) | 2006-02-21 | 2011-09-20 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | Nanoparticles for immunotherapy |
| CA2643322C (en) | 2006-02-24 | 2015-07-21 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| EP2010530A2 (en) | 2006-03-23 | 2009-01-07 | Novartis AG | Methods for the preparation of imidazole-containing compounds |
| JP2009534309A (ja) | 2006-03-31 | 2009-09-24 | マサチューセッツ インスティテュート オブ テクノロジー | 治療剤の標的化送達のためのシステム |
| CA2649149A1 (en) | 2006-04-11 | 2007-10-25 | Koko Kosmetikvertrieb Gmbh & Co. Kg | Nanoparticle containing nicotine and/or cotinine, dispersions, and use thereof |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| WO2007137117A2 (en) | 2006-05-17 | 2007-11-29 | Massachusetts Institute Of Technology | Aptamer-directed drug delivery |
| EP2530086B1 (en) | 2006-06-12 | 2019-03-20 | Kuros Biosciences AG | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
| JP2010502766A (ja) | 2006-06-16 | 2010-01-28 | フロリダ アトランティック ユニヴァーシティ | アジュバントとしてのキチン微粒子 |
| WO2007149802A2 (en) | 2006-06-19 | 2007-12-27 | 3M Innovative Properties Company | Formulation for delivery of immune response modifiers |
| US9381477B2 (en) | 2006-06-23 | 2016-07-05 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| JP2009541485A (ja) | 2006-06-26 | 2009-11-26 | ミューチュアル ファーマシューティカル カンパニー，インク． | 活性剤組成物 |
| WO2008019142A2 (en) | 2006-08-04 | 2008-02-14 | Massachusetts Institute Of Technology | Oligonucleotide systems for targeted intracellular delivery |
| WO2008019366A2 (en) | 2006-08-07 | 2008-02-14 | Ludwig Institute For Cancer Research | Methods and compositions for increased priming of t-cells through cross-presentation of exogenous antigens |
| CN101500937A (zh) | 2006-08-11 | 2009-08-05 | 万能药生物有限公司 | 用于递送活性成分的粒子及其制备方法和组合物 |
| NZ575273A (en) * | 2006-09-07 | 2012-02-24 | Glaxosmithkline Biolog Sa | Method for making combination vaccine comprising inactivated poliovirus type 1, diptheria toxoid and tetanus toxoid |
| WO2008033432A2 (en) | 2006-09-12 | 2008-03-20 | Coley Pharmaceutical Group, Inc. | Immune modulation by chemically modified ribonucleosides and oligoribonucleotides |
| EP2083857A4 (en) | 2006-09-22 | 2010-03-24 | Dana Farber Cancer Res Inc | METHOD FOR TREATING INTERFERENCE IN CONNECTION WITH MICA |
| JP2010505883A (ja) | 2006-10-12 | 2010-02-25 | ザ ユニバーシティー オブ クイーンズランド | 免疫応答を調節するための組成物および方法 |
| WO2008147456A2 (en) | 2006-11-20 | 2008-12-04 | Massachusetts Institute Of Technology | Drug delivery systems using fc fragments |
| SG177141A1 (en) * | 2006-12-06 | 2012-01-30 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
| US20080213377A1 (en) | 2006-12-08 | 2008-09-04 | Bhatia Sangeeta N | Delivery of Nanoparticles and/or Agents to Cells |
| EP1932516A1 (en) | 2006-12-11 | 2008-06-18 | Universiteit Utrecht Holding B.V. | Anti-inflammatory compounds containing compositions for treatment of cancer |
| WO2008071774A1 (en) | 2006-12-14 | 2008-06-19 | Cytos Biotechnology Ag | Purification process for coat protein of rna bacteriophages |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| PL2115140T3 (pl) | 2007-01-31 | 2017-03-31 | Yu | Dodatnio naładowane rozpuszczalne w wodzie proleki 1H-imidazo[4,5-c]chinolino-4-amin i powiązane związki o bardzo wysokich wskaźnikach penetracji przez skórę |
| SI2510946T1 (sl) | 2007-02-07 | 2015-12-31 | The Regents Of The University Of California | Konjugati sintetičnih agonistov TLR in njihove uporabe |
| EP2134830A2 (en) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
| WO2008115641A2 (en) | 2007-02-15 | 2008-09-25 | Yale University | Modular nanoparticles for adaptable vaccines |
| EP3269384A1 (en) | 2007-03-07 | 2018-01-17 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of autoimmune conditions |
| WO2008118861A2 (en) | 2007-03-23 | 2008-10-02 | The University Of North Carolina At Chapel Hill | Discrete size and shape specific organic nanoparticles designed to elicit an immune response |
| US11246831B2 (en) | 2007-03-30 | 2022-02-15 | Particle Sciences, Inc. | Particle formulations and uses thereof |
| WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
| WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| WO2008124165A2 (en) | 2007-04-09 | 2008-10-16 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
| AU2008239795A1 (en) | 2007-04-12 | 2008-10-23 | Emory University | Novel strategies for delivery of active agents using micelles and particles |
| EP1982729A1 (en) | 2007-04-20 | 2008-10-22 | Cytos Biotechnology AG | Vaccination Regimen for B-Cell Vaccines |
| US20080294089A1 (en) * | 2007-06-06 | 2008-11-27 | Biovaluation & Analysis, Inc. | Dendritic Polymers for Use in Acoustically Mediated Intracellular Drug Delivery in vivo |
| US20090047318A1 (en) | 2007-08-16 | 2009-02-19 | Abbott Cardiovascular Systems Inc. | Nanoparticle-coated medical devices and formulations for treating vascular disease |
| US8394914B2 (en) | 2007-08-24 | 2013-03-12 | Board Of Trustees Of Michigan State University | Functional polyglycolide nanoparticles derived from unimolecular micelles |
| WO2009027971A2 (en) | 2007-08-27 | 2009-03-05 | H2Q Water Industries Ltd. | Antimicrobial polymers |
| US20090130210A1 (en) | 2007-09-11 | 2009-05-21 | Raheja Praveen | Pharmaceutical compositions of sirolimus |
| EP2197457A4 (en) * | 2007-09-26 | 2010-10-27 | Aparna Biosciences | THERAPEUTIC VACCINE POLYELECTROLYTE NANOPARTICLE COMPOSITIONS |
| EP2394657A1 (en) | 2007-10-12 | 2011-12-14 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
| WO2009069448A1 (ja) | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | 日本脳炎ワクチン用のアジュバント及び日本脳炎ワクチン |
| WO2009076158A1 (en) * | 2007-12-07 | 2009-06-18 | Novartis Ag | Compositions for inducing immune responses |
| WO2009078754A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of poorly water soluble pharmaceutically active substances |
| JP6088123B2 (ja) * | 2008-02-01 | 2017-03-01 | アルファ−オー・ペプチドズ・アーゲーＡｌｐｈａ−Ｏ Ｐｅｐｔｉｄｅｓ Ａｇ | ワクチンとして有用な自己会合ペプチドナノ粒子 |
| WO2009106999A2 (en) | 2008-02-28 | 2009-09-03 | Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts | Hollow nanoparticles and uses thereof |
| JP2011525477A (ja) | 2008-03-04 | 2011-09-22 | リクイディア・テクノロジーズ・インコーポレーテッド | 免疫調節剤粒子および処置方法 |
| CN103990120B (zh) | 2008-04-01 | 2018-06-05 | 伊耐特免疫治疗有限公司 | 抗感染剂及其用途 |
| US20090297621A1 (en) | 2008-06-03 | 2009-12-03 | Abbott Cardiovascular Systems Inc. | Microparticles For The Treatment Of Disease |
| US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
| HUE047004T2 (hu) | 2008-06-16 | 2020-04-28 | Pfizer | Hatóanyaggal töltött polimer nanorészecskék és eljárások elõállításukra és alkalmazásukra |
| CN105147608B (zh) | 2008-06-26 | 2019-12-10 | 安特里奥公司 | 真皮递送 |
| WO2010003009A2 (en) | 2008-07-01 | 2010-01-07 | Emory University | Synergistic induction of humoral and cellular immunity by combinatorial activation of toll-like receptors |
| JP5667566B2 (ja) | 2008-08-06 | 2015-02-12 | ノバルティス アーゲー | 免疫原性組成物における使用のための微粒子 |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| EP2324025A1 (en) | 2008-08-11 | 2011-05-25 | Smithkline Beecham Corporation | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
| WO2010018132A1 (en) | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Compounds |
| ES2433371T3 (es) | 2008-08-11 | 2013-12-10 | Glaxosmithkline Llc | Derivados de purina para uso en el tratamiento de enfermedades alérgicas, inflamatorias e infecciosas |
| US8323696B2 (en) | 2008-08-29 | 2012-12-04 | Ecole Polytechnique Federale De Lausanne | Nanoparticles for immunotherapy |
| US8889635B2 (en) | 2008-09-30 | 2014-11-18 | The Regents Of The University Of Michigan | Dendrimer conjugates |
| EP2172193A1 (en) | 2008-10-02 | 2010-04-07 | Capsulution Nanoscience AG | Improved nanoparticulate compositions of poorly soluble compounds |
| WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US8343498B2 (en) * | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8591905B2 (en) * | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US20100098770A1 (en) | 2008-10-16 | 2010-04-22 | Manikandan Ramalingam | Sirolimus pharmaceutical formulations |
| US20120015899A1 (en) | 2008-10-25 | 2012-01-19 | Plant Bioscience, Limited | Modified plant virus particles and uses therefor |
| JP5727937B2 (ja) | 2008-11-06 | 2015-06-03 | ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | ベンゾアセピン誘導体の合成方法 |
| CN101822838B (zh) * | 2009-03-05 | 2012-06-27 | 无锡纳奥生物医药有限公司 | 靶向识别肿瘤细胞的纳米药物载体材料及其制备和应用 |
| US20100233231A1 (en) | 2009-03-10 | 2010-09-16 | Roger Labrecque | Use of cryogenic processing to obtain a substantially-thickened formulation |
| CA2756996C (en) | 2009-04-01 | 2018-12-11 | University Of Miami | Vaccine compositions and methods of use thereof |
| WO2010123569A2 (en) | 2009-04-21 | 2010-10-28 | Selecta Biosciences, Inc. | Immunonanotherapeutics providing a th1-biased response |
| GB0908129D0 (en) | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
| AU2010254549B2 (en) | 2009-05-27 | 2016-10-20 | Selecta Biosciences, Inc. | Nanocarriers possessing components with different rates of release |
| CN102802624A (zh) | 2009-06-19 | 2012-11-28 | 太阳医药高级研发有限公司 | 药物的纳米分散体以及它的制备方法 |
| EP3058953A1 (en) | 2009-07-07 | 2016-08-24 | The Research Foundation Of State University Of New York | Lipidic compositions for induction of immune tolerance |
| MX343908B (es) | 2009-08-26 | 2016-11-28 | Selecta Biosciences Inc * | Composiciones que inducen la ayuda de las células t. |
| JP5796909B2 (ja) * | 2009-11-25 | 2015-10-21 | サイトメティックス、インコーポレイテッド | アラキドン酸類縁体、及びそれによる鎮痛治療 |
| EP2515942B1 (en) | 2009-12-15 | 2020-02-12 | Pfizer Inc. | Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers |
| US20110171248A1 (en) | 2010-01-08 | 2011-07-14 | Selecta Biosciences, Inc. | Synthetic virus-like particles conjugated to human papillomavirus capsid peptides for use as vaccines |
| US20110229556A1 (en) | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid-coated polymer particles for immune stimulation |
| US20110272836A1 (en) | 2010-04-12 | 2011-11-10 | Selecta Biosciences, Inc. | Eccentric vessels |
| US20110262491A1 (en) | 2010-04-12 | 2011-10-27 | Selecta Biosciences, Inc. | Emulsions and methods of making nanocarriers |
| CN105194665A (zh) | 2010-05-26 | 2015-12-30 | 西莱克塔生物科技公司 | 具有不偶合的佐剂的纳米载体组合物 |
| AU2011291522A1 (en) | 2010-08-20 | 2013-01-24 | Selecta Biosciences, Inc. | Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza A virus M2E |
| MX2013002173A (es) | 2010-08-23 | 2013-05-06 | Selecta Biosciences Inc | Formas farmaceuticas dirigidas de epitopos multiples para la induccion de una respuesta inmunologica frente a antigenos. |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| US20120171229A1 (en) | 2010-12-30 | 2012-07-05 | Selecta Biosciences, Inc. | Synthetic nanocarriers with reactive groups that release biologically active agents |
| EP2694040A4 (en) | 2011-03-25 | 2014-09-03 | Selecta Biosciences Inc | SYNTHETIC NANOTRACKERS WITH OSMOTICALLY MEDIATED RELEASE |
| CN118078979A (zh) | 2011-04-29 | 2024-05-28 | 西莱克塔生物科技公司 | 用于降低针对治疗性蛋白的免疫应答的致耐受性合成纳米载体 |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| WO2013036302A1 (en) | 2011-09-06 | 2013-03-14 | Selecta Biosciences, Inc. | Induced tolerogenic dendritic cells for generating cd8+ regulatory t cells |
| US10434088B2 (en) | 2013-05-03 | 2019-10-08 | Selecta Biosciences, Inc. | Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose |
| DK3003306T3 (da) | 2013-06-04 | 2020-11-30 | Selecta Biosciences Inc | Gentagen indgivelse af ikke-immunosupressive antigenspecifikke immunterapeutika |
| US20150359865A1 (en) | 2014-06-17 | 2015-12-17 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers for t-cell-mediated autoimmune disease |
| US20160220501A1 (en) | 2015-02-03 | 2016-08-04 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers to reduce immune responses to therapeutic proteins |
| EA201692512A1 (ru) | 2014-06-25 | 2017-07-31 | Селекта Байосайенсиз, Инк. | Способы и композиции для лечения синтетическими наноносителями и ингибиторами иммунной контрольной точки |
| WO2016037165A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
| HUE054894T2 (hu) | 2014-11-05 | 2021-10-28 | Selecta Biosciences Inc | Rapamicint stabil, túltelített állapotban tartalmazó szintetikus nanohordozókkal kapcsolatos módszerek és készítmények |
-
2011
- 2011-05-26 CN CN201510646557.7A patent/CN105194665A/zh active Pending
- 2011-05-26 ES ES11787442.0T patent/ES2661978T3/es active Active
- 2011-05-26 CA CA2798994A patent/CA2798994A1/en not_active Abandoned
- 2011-05-26 MX MX2012013716A patent/MX355036B/es active IP Right Grant
- 2011-05-26 US US13/116,542 patent/US9066978B2/en not_active Expired - Fee Related
- 2011-05-26 MX MX2012013714A patent/MX352324B/es active IP Right Grant
- 2011-05-26 US US13/116,453 patent/US20110293700A1/en not_active Abandoned
- 2011-05-26 KR KR1020127030842A patent/KR20130108984A/ko not_active Ceased
- 2011-05-26 CN CN2011800254962A patent/CN102917731A/zh active Pending
- 2011-05-26 CA CA2798739A patent/CA2798739A1/en not_active Abandoned
- 2011-05-26 EA EA201500857A patent/EA201500857A1/ru unknown
- 2011-05-26 AU AU2011258156A patent/AU2011258156B2/en not_active Ceased
- 2011-05-26 KR KR1020127030973A patent/KR20130108988A/ko not_active Ceased
- 2011-05-26 EP EP11787451.1A patent/EP2575773A4/en not_active Withdrawn
- 2011-05-26 US US13/116,556 patent/US20110293723A1/en not_active Abandoned
- 2011-05-26 AU AU2011258171A patent/AU2011258171B2/en not_active Ceased
- 2011-05-26 WO PCT/US2011/038210 patent/WO2011150258A1/en not_active Ceased
- 2011-05-26 PL PL11787442T patent/PL2575876T3/pl unknown
- 2011-05-26 WO PCT/US2011/038190 patent/WO2011150240A1/en not_active Ceased
- 2011-05-26 EA EA201291156A patent/EA030863B1/ru not_active IP Right Cessation
- 2011-05-26 PT PT117874420T patent/PT2575876T/pt unknown
- 2011-05-26 JP JP2013512256A patent/JP6324068B2/ja not_active Expired - Fee Related
- 2011-05-26 US US13/116,488 patent/US20110293701A1/en not_active Abandoned
- 2011-05-26 CA CA2798493A patent/CA2798493A1/en not_active Abandoned
- 2011-05-26 CN CN2011800254799A patent/CN102905729A/zh active Pending
- 2011-05-26 CN CN201610566374.9A patent/CN106177940A/zh active Pending
- 2011-05-26 JP JP2013512253A patent/JP6324067B2/ja active Active
- 2011-05-26 EP EP11787447.9A patent/EP2582393A4/en not_active Withdrawn
- 2011-05-26 CA CA2798323A patent/CA2798323A1/en not_active Abandoned
- 2011-05-26 EA EA201890942A patent/EA201890942A1/ru unknown
- 2011-05-26 BR BR112012029912A patent/BR112012029912A2/pt not_active Application Discontinuation
- 2011-05-26 MX MX2012013715A patent/MX2012013715A/es unknown
- 2011-05-26 MX MX2012013713A patent/MX2012013713A/es unknown
- 2011-05-26 CN CN2011800254854A patent/CN103118700A/zh active Pending
- 2011-05-26 EP EP17205287.0A patent/EP3388081A1/en not_active Withdrawn
- 2011-05-26 KR KR1020187024208A patent/KR20180099900A/ko not_active Ceased
- 2011-05-26 EA EA201291157A patent/EA030620B1/ru not_active IP Right Cessation
- 2011-05-26 CN CN201180025504.3A patent/CN102905728B/zh not_active Expired - Fee Related
- 2011-05-26 KR KR1020127030972A patent/KR20130108987A/ko not_active Ceased
- 2011-05-26 EA EA201291158A patent/EA023397B1/ru not_active IP Right Cessation
- 2011-05-26 AU AU2011258147A patent/AU2011258147B2/en not_active Ceased
- 2011-05-26 NO NO11787442A patent/NO2575876T3/no unknown
- 2011-05-26 CN CN201611150052.2A patent/CN107080839A/zh active Pending
- 2011-05-26 EA EA201291154A patent/EA030813B1/ru not_active IP Right Cessation
- 2011-05-26 EP EP11787442.0A patent/EP2575876B1/en not_active Not-in-force
- 2011-05-26 KR KR1020127030841A patent/KR20130108983A/ko not_active Ceased
- 2011-05-26 AU AU2011258165A patent/AU2011258165B2/en not_active Ceased
- 2011-05-26 BR BR112012029917A patent/BR112012029917A2/pt not_active IP Right Cessation
- 2011-05-26 JP JP2013512250A patent/JP6371058B2/ja not_active Expired - Fee Related
- 2011-05-26 CN CN201611271087.1A patent/CN107029223A/zh active Pending
- 2011-05-26 CN CN201611149236.7A patent/CN107096021A/zh active Pending
- 2011-05-26 CN CN201611271086.7A patent/CN107029222A/zh active Pending
- 2011-05-26 JP JP2013512255A patent/JP6367554B2/ja not_active Expired - Fee Related
- 2011-05-26 DK DK11787442.0T patent/DK2575876T3/en active
- 2011-05-26 WO PCT/US2011/038200 patent/WO2011150249A1/en not_active Ceased
- 2011-05-26 BR BR112012029823-2A patent/BR112012029823A2/pt not_active IP Right Cessation
- 2011-05-26 EP EP11787434.7A patent/EP2575886A4/en not_active Withdrawn
- 2011-05-26 WO PCT/US2011/038218 patent/WO2011150264A2/en not_active Ceased
-
2012
- 2012-10-25 IL IL222680A patent/IL222680B/en active IP Right Grant
- 2012-10-28 IL IL222725A patent/IL222725B/en active IP Right Grant
- 2012-10-28 IL IL222724A patent/IL222724A0/en unknown
- 2012-10-28 IL IL222722A patent/IL222722B/en active IP Right Grant
-
2015
- 2015-05-20 US US14/717,451 patent/US9764031B2/en not_active Expired - Fee Related
-
2016
- 2016-07-11 JP JP2016137027A patent/JP2017008054A/ja active Pending
- 2016-07-11 JP JP2016137048A patent/JP2017008055A/ja active Pending
- 2016-07-11 JP JP2016137057A patent/JP2017014216A/ja active Pending
- 2016-07-11 JP JP2016137068A patent/JP6407208B2/ja not_active Expired - Fee Related
-
2017
- 2017-02-17 AU AU2017201082A patent/AU2017201082A1/en not_active Abandoned
- 2017-02-17 AU AU2017201080A patent/AU2017201080A1/en not_active Abandoned
- 2017-02-20 AU AU2017201143A patent/AU2017201143A1/en not_active Abandoned
- 2017-02-20 AU AU2017201145A patent/AU2017201145A1/en not_active Abandoned
- 2017-08-23 US US15/684,896 patent/US20180043023A1/en not_active Abandoned
- 2017-10-11 JP JP2017197308A patent/JP2018052937A/ja active Pending
- 2017-10-16 JP JP2017199990A patent/JP2018052940A/ja active Pending
- 2017-11-07 JP JP2017214375A patent/JP2018065813A/ja active Pending
-
2018
- 2018-06-13 IL IL260015A patent/IL260015A/en unknown
-
2019
- 2019-09-09 JP JP2019163782A patent/JP2020023492A/ja active Pending
- 2019-09-24 IL IL26961519A patent/IL269615A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013528181A5 (cg-RX-API-DMAC7.html) | ||
| JP2017014217A5 (cg-RX-API-DMAC7.html) | ||
| JP2013526617A5 (cg-RX-API-DMAC7.html) | ||
| Rappuoli et al. | Transforming vaccinology | |
| ES2328697T5 (es) | Composiciones inmunogénicas basadas en micropartículas que comprenden toxoide adsorbido y un antígeno que contiene un polisacárido | |
| JP6407208B2 (ja) | 合成ナノキャリア混合ワクチン | |
| Wack et al. | Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice | |
| Hume et al. | Platform technologies for modern vaccine manufacturing | |
| Singh et al. | A preliminary evaluation of alternative adjuvants to alum using a range of established and new generation vaccine antigens | |
| EP2066344B2 (en) | Inactivated Poliovirus combination vaccine | |
| Goetz et al. | Vaccine adjuvants for infectious disease in the clinic | |
| Jeong et al. | Preclinical study of influenza bivalent vaccine delivered with a two compartmental microneedle array | |
| CA2524217A1 (en) | Compositions for inducing immune responses | |
| Dey et al. | Novel adjuvants and delivery systems for enhancing immune responses induced by immunogens | |
| ES2664753T3 (es) | Composiciones de inducción de respuestas inmunes | |
| JP2019112448A (ja) | ナイーブな対象のためのワクチン組成物 | |
| Yang et al. | Mucosal vaccines against respiratory syncytial virus | |
| Michel et al. | Therapeutic vaccination against chronic hepatitis B virus infection | |
| US9421251B2 (en) | Rapid responses to delayed booster immunisations | |
| JP7478144B2 (ja) | 低減用量の不活化ポリオウイルスを含む混合ワクチン組成物およびそれを調製するための方法 | |
| Morelli et al. | ISCOMATRIX adjuvant in the development of prophylactic and therapeutic vaccines | |
| Rezk et al. | Harnessing the Potential of mRNA Vaccines Against Infectious Diseases | |
| Franc | Vakcíny z pohledu farmaceuta Vaccines from the perspective of a pharmacist | |
| Zarandi et al. | Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review | |
| SUJATHA | A REVIEW ON VACCINE DEVELOPMENT STRATEGIES AGAINST COVID-19 |