ATE394674T1 - Funktionalisierte nanopartikel und verwendungsverfahren - Google Patents

Funktionalisierte nanopartikel und verwendungsverfahren

Info

Publication number
ATE394674T1
ATE394674T1 AT03728505T AT03728505T ATE394674T1 AT E394674 T1 ATE394674 T1 AT E394674T1 AT 03728505 T AT03728505 T AT 03728505T AT 03728505 T AT03728505 T AT 03728505T AT E394674 T1 ATE394674 T1 AT E394674T1
Authority
AT
Austria
Prior art keywords
methods
functionalized nanoparticles
nucleic acid
acid molecules
molecules
Prior art date
Application number
AT03728505T
Other languages
English (en)
Inventor
Weihong Tan
Jin Shouguang
Xiaojun Zhao
Rovelyn Dytioco
Timothy Drake
Lisa Hilliard
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Application granted granted Critical
Publication of ATE394674T1 publication Critical patent/ATE394674T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552Glass or silica
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Silicon Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Powder Metallurgy (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT03728505T 2002-04-22 2003-04-22 Funktionalisierte nanopartikel und verwendungsverfahren ATE394674T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37440502P 2002-04-22 2002-04-22
US37512202P 2002-04-22 2002-04-22

Publications (1)

Publication Number Publication Date
ATE394674T1 true ATE394674T1 (de) 2008-05-15

Family

ID=29254555

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03728505T ATE394674T1 (de) 2002-04-22 2003-04-22 Funktionalisierte nanopartikel und verwendungsverfahren

Country Status (11)

Country Link
US (1) US7524630B2 (de)
EP (1) EP1499895B1 (de)
JP (1) JP4381826B2 (de)
CN (1) CN100419426C (de)
AT (1) ATE394674T1 (de)
AU (1) AU2003234196A1 (de)
CA (1) CA2482611A1 (de)
DE (1) DE60320780D1 (de)
HK (1) HK1075698A1 (de)
RU (1) RU2004133894A (de)
WO (1) WO2003089906A2 (de)

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
CN1312479C (zh) * 2003-08-08 2007-04-25 清华大学 一种纳米荧光磁粒及其制备方法
EP1680443B9 (de) 2003-11-05 2014-09-03 Dana-Farber Cancer Institute, Inc. Peptide mit stabilisierter alpha-helix und deren verwendungen
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
JP2008501509A (ja) * 2004-06-01 2008-01-24 ザ ペン ステイト リサーチ ファウンデーション 非凝集性コア/シェル型ナノコンポジット粒子
RU2417232C2 (ru) * 2004-06-04 2011-04-27 Басф Се Способ маркирования материалов
AU2005326758B2 (en) 2004-06-23 2011-07-14 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex
US7405002B2 (en) * 2004-08-04 2008-07-29 Agency For Science, Technology And Research Coated water-soluble nanoparticles comprising semiconductor core and silica coating
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
KR100613189B1 (ko) 2004-11-15 2006-08-21 미지테크주식회사 은 나노 합성 섬유 및 그 제조방법
KR100624447B1 (ko) 2004-11-25 2006-09-18 삼성전자주식회사 은 나노 입자를 이용한 핵산의 정제 방법
US20080135490A1 (en) * 2005-01-07 2008-06-12 Board Of Trustees Of The University Of Arkansas Quantum dot biolabeling and immunomagnetic separation for detection of contaminants
US7699979B2 (en) * 2005-01-07 2010-04-20 Board Of Trustees Of The University Of Arkansas Separation system and efficient capture of contaminants using magnetic nanoparticles
US20060217893A1 (en) * 2005-01-07 2006-09-28 Yanbin Li Method for detecting an unknown contaminant concentration in a substance
US20070055013A1 (en) * 2005-02-21 2007-03-08 Noriho Kamiya Substrate and method of immobilizing protein
CA2599975C (en) * 2005-03-03 2013-07-30 University Of North Dakota Surfaces coated with target-induced fluorescent compounds for detection of target elements
CN1861628B (zh) * 2005-05-11 2010-05-05 上海师范大学 一种分离中药蛋白质的方法
KR101111747B1 (ko) * 2005-05-16 2012-06-12 삼성엘이디 주식회사 혼합 나노 입자 및 이를 이용한 전자소자
WO2006136314A1 (de) 2005-06-23 2006-12-28 Siemens Medical Solutions Diagnostics Gmbh Magnetpartikel mit einer geschlossenen, ultradünnen silikaschicht, verfahren zu deren herstellung und verwendung
US20110097277A1 (en) 2005-08-25 2011-04-28 University Of Washington Particles coated with zwitterionic polymers
CA2621352A1 (en) * 2005-09-08 2007-03-15 Biterials Co., Ltd. Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof
US8906609B1 (en) 2005-09-26 2014-12-09 Arrowhead Center, Inc. Label-free biomolecule sensor based on surface charge modulated ionic conductance
US8168447B2 (en) * 2005-10-07 2012-05-01 University Of Florida Research Foundation, Inc. Multiple component nanoparticles for multiplexed signaling and optical encoding
CN100441677C (zh) * 2005-10-20 2008-12-10 上海师范大学 免疫磁性纳米粒子细菌分离器及其制法和应用
ATE541811T1 (de) 2005-12-06 2012-02-15 Lg Chemical Ltd Herstellungsverfahren für kernschalen- nanopartikel
US20090317802A1 (en) * 2005-12-09 2009-12-24 Bhatia Sangeeta N Compositions and Methods to Monitor RNA Delivery to Cells
WO2007075456A2 (en) * 2005-12-15 2007-07-05 University Of Florida Research Foundation, Inc. Colorimetric light switching probe for ultrasensitive detection of target compounds
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
CN100371713C (zh) * 2006-01-13 2008-02-27 东南大学 金或银纳米粒子的表面功能化及比色检测生物分子的方法
JP4670659B2 (ja) * 2006-01-25 2011-04-13 住友電気工業株式会社 蛍光標識金属粉末、ならびに該蛍光標識金属粉末を含有する異方導電膜、実装品
FR2898519B1 (fr) * 2006-03-20 2009-01-09 Commissariat Energie Atomique Nanoparticules notamment a structure coeur coquilles, enrobees
EP2007435B1 (de) 2006-03-31 2019-12-18 Massachusetts Institute Of Technology System zur gezielten verabreichung von heilmitteln
CA2652280C (en) 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP1889810A1 (de) * 2006-08-10 2008-02-20 HeiQ Materials AG Verfahren zur Herstellung von Nanopartikeln enthaltendem Pulver mittels Flammenspritzpyrolyse und zugehörige Verwendungen
US20100120016A1 (en) * 2006-09-01 2010-05-13 Yanbin Li Methods and systems for detection of contaminants
CN1987454B (zh) * 2006-10-31 2011-01-12 成都夸常医学工业有限公司 含定向纳米结构功能化区的纳米结构组成及其制备和应用方法
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
US20110189101A1 (en) * 2006-12-01 2011-08-04 National University Corporation Shimane University Fluorescent labeling agent and fluorescent labeling method
CA2671850A1 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
MX2009007101A (es) 2006-12-29 2009-12-01 Univ Washington Superficies y materiales antibioincrustación bifuncionales.
JP5649825B2 (ja) 2007-01-31 2015-01-07 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 安定化させたp53ペプチドおよびその使用法
US9217129B2 (en) * 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
ES2430067T3 (es) 2007-03-28 2013-11-18 President And Fellows Of Harvard College Polipéptidos cosidos
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20090074828A1 (en) 2007-04-04 2009-03-19 Massachusetts Institute Of Technology Poly(amino acid) targeting moieties
US8062215B2 (en) * 2007-04-13 2011-11-22 Ethicon Endo-Surgery, Inc. Fluorescent nanoparticle scope
EP2137533A2 (de) * 2007-04-19 2009-12-30 3M Innovative Properties Company Verwendung wasserdispergierbarer silica-nanopartikel zur befestigung von biomolekülen
US8597959B2 (en) * 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
JP4981510B2 (ja) * 2007-04-27 2012-07-25 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
DE102007020220B3 (de) 2007-04-28 2008-11-13 Forschungszentrum Karlsruhe Gmbh Verfahren zur magnetisch unterstützten Extraktion
US20080269086A1 (en) * 2007-04-30 2008-10-30 Atanu Adhvaryu Functionalized nanosphere lubricants
EP2185573A4 (de) * 2007-07-26 2011-12-07 Cellay Inc Hochsichtbare chromosomenspezifische sonden und entsprechende verfahren
EP2025364A1 (de) * 2007-08-13 2009-02-18 Procter & Gamble International Operations SA. Zusammensetzungen mit farbstofftragenden Teilchen
DE602007011060D1 (de) * 2007-08-13 2011-01-20 Procter & Gamble Internat Operations Sa Sprühtrocknungsverfahren zur Herstellung farbstoffhaltiger Teilchen
EP2062946B1 (de) * 2007-08-13 2012-06-06 Procter & Gamble International Operations SA Farbstoffhaltige Teilchen
JP5192752B2 (ja) * 2007-08-15 2013-05-08 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
US20090047222A1 (en) * 2007-08-15 2009-02-19 Ben Gu Color Stable Peroxide Containing Dentifrice Formulations With Dye Encapsulated Silica Shell Nanoparticles
CN105770878A (zh) 2007-10-12 2016-07-20 麻省理工学院 疫苗纳米技术
US9533006B2 (en) 2007-11-19 2017-01-03 University Of Washington Marine coatings
SI2271938T1 (sl) 2008-04-11 2014-07-31 Board Of Regents Of The University Of Texas System Postopek in naprava za ojačenje električno generirane kemiluminiscence nanodelcev
EP2626693A3 (de) 2008-05-08 2014-10-01 Board of Regents of the University of Texas System Nanostrukturierte lumineszente Materialien zur Verwendung in elektrogenerierter Chemolumineszenz
JP2009275006A (ja) * 2008-05-16 2009-11-26 Univ Of Tokyo 低酸素環境測定用試薬
WO2010011313A2 (en) * 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides
WO2010014222A1 (en) * 2008-07-30 2010-02-04 Dana-Farber Cancer Institute, Inc. Compositions for detecting cell death and methods of use thereof
CN104961795A (zh) * 2008-09-22 2015-10-07 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8277812B2 (en) * 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8512417B2 (en) 2008-11-14 2013-08-20 Dune Sciences, Inc. Functionalized nanoparticles and methods of forming and using same
US10080578B2 (en) 2008-12-16 2018-09-25 Nico Corporation Tissue removal device with adjustable delivery sleeve for neurosurgical and spinal surgery applications
CN101444503B (zh) * 2008-12-31 2011-02-02 江苏大学 一种水飞蓟宾高效长效制剂及其制法
CN101439025B (zh) * 2008-12-31 2011-05-11 江苏大学 一种水飞蓟素高效长效制剂及其制法
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
JP5717720B2 (ja) 2009-04-15 2015-05-13 コーネル ユニバーシティCornell University シリカの高密度化で改良された蛍光シリカナノ粒子
EP2435092A2 (de) 2009-05-27 2012-04-04 Selecta Biosciences, Inc. Nanoträger mit komponenten mit verschiedenen freisetzungsraten
US9377449B2 (en) 2009-06-15 2016-06-28 William Marsh Rice University Nanocomposite oil sensors for downhole hydrocarbon detection
WO2010147859A1 (en) * 2009-06-15 2010-12-23 William Marsh Rice University Nanomaterial-containing signaling compositions for assay of flowing liquid streams and geological formations and methods for use thereof
WO2011008260A2 (en) 2009-07-13 2011-01-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
AU2010313105B2 (en) 2009-11-02 2015-02-26 Pulse Therapeutics, Inc. Magnetomotive stator system and methods for wireless control of magnetic rotors
JP5868862B2 (ja) 2009-11-06 2016-02-24 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション 双性イオンポリマーバイオコンジュゲートおよび関連する方法
CN102192986B (zh) * 2010-03-19 2014-06-11 成都盛泰尔生物医药科技有限公司 一种心肌肌钙蛋白i的检测试剂
JP5503382B2 (ja) * 2010-04-05 2014-05-28 古河電気工業株式会社 イムノクロマトグラフィー用複合粒子
US20120015344A1 (en) * 2010-05-14 2012-01-19 1. Board of Trustees of MICHIGAN STATE UNIVERSITY Methods, compositions, and apparatus for the detection of viral strains
ES2661978T3 (es) 2010-05-26 2018-04-04 Selecta Biosciences, Inc. Vacunas multivalentes de nanovehículos sintéticos
WO2012016186A1 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Macrocyclic kinase inhibitors and uses thereof
WO2012021516A2 (en) * 2010-08-09 2012-02-16 The Trustees Of The University Of Pennsylvania Nanoparticle-oligonucletide hybrid structures and methods of use thereof
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
US8962804B2 (en) 2010-10-08 2015-02-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
AU2011312106B8 (en) 2010-10-08 2017-09-14 City Of Hope A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
US8992985B2 (en) 2010-11-05 2015-03-31 Massachusetts Institute Of Technology Core-shell magnetic particles and related methods
GB201019434D0 (en) * 2010-11-17 2010-12-29 Isis Innovation Sonosensitive nanoparticles
JPWO2012111686A1 (ja) * 2011-02-15 2014-07-07 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
EP2677316A4 (de) * 2011-02-15 2014-05-14 Kyowa Medex Co Ltd Streptavidingebundene magnetische teilchen und herstellungsverfahren dafür
JPWO2012111687A1 (ja) * 2011-02-15 2014-07-07 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
US8916696B2 (en) 2011-06-12 2014-12-23 City Of Hope Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
CN105873910A (zh) 2011-07-01 2016-08-17 哈佛大学的校长及成员们 大环胰岛素降解酶(ide)抑制剂及其用途
CN109172819A (zh) 2011-07-29 2019-01-11 西莱克塔生物科技公司 产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体
EP2760471B9 (de) 2011-09-30 2017-07-19 Dana-Farber Cancer Institute, Inc. Therapeutische peptide
KR102056932B1 (ko) 2011-10-10 2019-12-17 시티 오브 호프 메디토프와 메디토프-결합 항체 및 이들의 용도
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
EP2858661B1 (de) 2011-12-29 2020-04-22 Dana-Farber Cancer Institute, Inc. Stabilisierte antivirale fusionsspiralen
KR20130084091A (ko) 2012-01-16 2013-07-24 삼성전자주식회사 화상형성장치
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
WO2013120110A1 (en) * 2012-02-10 2013-08-15 Lockheed Martin Corporation Nanoparticle paste formulations and methods for production and use thereof
US9428553B2 (en) 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN102618257B (zh) * 2012-03-09 2014-01-29 浙江大学 一种上转换荧光纳米材料的表面包覆方法
WO2013154735A1 (en) 2012-04-10 2013-10-17 Rossi John J Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
EP4302821A3 (de) 2012-05-15 2024-06-26 Pulse Therapeutics, Inc. Magnetbasierte systeme
US9883878B2 (en) 2012-05-15 2018-02-06 Pulse Therapeutics, Inc. Magnetic-based systems and methods for manipulation of magnetic particles
CN102786030B (zh) * 2012-07-06 2014-03-12 江苏大学 一种通过溶剂处理制备多肽纳米薄膜的方法
KR101543583B1 (ko) * 2012-08-24 2015-08-11 단국대학교 산학협력단 생체 분자 분석용 미소 입자 및 키트와 생체 분자 분석용 미소 입자의 제조 방법
DK2920197T3 (da) 2012-09-26 2021-05-31 Harvard College Prolinlåste sammenhæftede peptider og anvendelser deraf
WO2014055564A1 (en) 2012-10-01 2014-04-10 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
WO2014065753A1 (en) * 2012-10-23 2014-05-01 Dso National Laboratories Direct visual detection of nucleic acid using gold nanoparticles
JP6526563B2 (ja) 2012-11-01 2019-06-05 エイルロン セラピューティクス,インコーポレイテッド 二置換アミノ酸ならびにその調製および使用の方法
WO2014107449A1 (en) * 2013-01-01 2014-07-10 The Trustees Of Columbia University In The City Of New York Molecule structure probe methods, devices, and systems
US20150322489A1 (en) * 2013-01-25 2015-11-12 Douglas Scientific, LLC Silica-based biological material isolation
US20160045612A1 (en) * 2013-02-19 2016-02-18 University Of Massachusetts Functionalized nanoparticles for medical treatments
SG10201700952XA (en) 2013-03-13 2017-04-27 Harvard College Stapled and stitched polypeptides and uses thereof
US10087215B2 (en) 2013-03-15 2018-10-02 Dana-Farber Cancer Institute, Inc. Stabilized SOS1 peptides
US10106590B2 (en) 2013-03-15 2018-10-23 Dana-Farber Cancer Institute, Inc. BH4 stabilized peptides and uses thereof
US10308926B2 (en) 2013-03-15 2019-06-04 Dana-Farber Cancer Institute, Inc. Stablized EZH2 peptides
JP6397886B2 (ja) 2013-03-15 2018-09-26 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 治療用ペプチド
US10227390B2 (en) 2013-06-14 2019-03-12 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
US9409148B2 (en) 2013-08-08 2016-08-09 Uchicago Argonne, Llc Compositions and methods for direct capture of organic materials from process streams
KR101660399B1 (ko) * 2013-08-23 2016-09-28 주식회사 메디센서 금 나노 입자를 포함하는 형광 입자 및 그 제조방법
WO2015034469A2 (en) * 2013-09-03 2015-03-12 Aneeve Nanotechnologies, Llc A process for cleaning carbon nanotubes and other nanostructured films
WO2015042585A1 (en) * 2013-09-23 2015-03-26 Rensselaer Polytechnic Institute Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations
US10925999B2 (en) 2013-10-08 2021-02-23 Trustees Of Tufts College Tunable covalently crosslinked hydrogels and methods of making the same
WO2015054493A1 (en) * 2013-10-09 2015-04-16 Nanocomposix, Inc. Encapsulated particles
US10513802B2 (en) 2013-11-08 2019-12-24 Tufts University Peptide-based nanofibrillar materials
BR112016012358A2 (pt) 2013-12-06 2017-09-26 Dana Farber Cancer Inst Inc peptídios terapêuticos
BR112016015198A2 (pt) * 2013-12-31 2017-08-08 Memorial Sloan Kettering Cancer Center Sistemas, métodos e aparelho para a produção de imagens multicanal de fontes fluorescentes em tempo real
CA2939006A1 (en) 2014-03-14 2015-09-17 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring nkg2d pathway function against cancers
JP6156229B2 (ja) * 2014-03-31 2017-07-05 株式会社Jvcケンウッド 粒子の製造方法
US10533039B2 (en) 2014-05-21 2020-01-14 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
JP6350654B2 (ja) * 2014-05-23 2018-07-04 株式会社島津製作所 磁性体粒子の操作方法
JP6734011B2 (ja) * 2014-06-06 2020-08-05 古河電気工業株式会社 生体分子検出用試験キット、及びこれを用いた生体分子の検出方法、並びにこれらに用いられる生体分子検出用試験片及び生体分子検出用標識試薬
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
CA2961029A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
KR20230066491A (ko) 2014-10-02 2023-05-15 시티 오브 호프 다가 메디토프, 메디토프 결합 항체 및 이의 용도
JP6182520B2 (ja) * 2014-12-01 2017-08-16 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
FR3031063B1 (fr) * 2014-12-30 2017-02-10 Biomerieux Sa Complexe multicouches, procede de fabrication et utilisation du complexe
ES2915384T3 (es) 2015-03-12 2022-06-22 Univ Tufts Materiales de seda con memoria de forma
AU2016232833A1 (en) 2015-03-18 2017-10-12 Dana-Farber Cancer Institute, Inc. Selective Mcl-1 binding peptides
CN107614003A (zh) 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
US11040976B2 (en) 2015-04-24 2021-06-22 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (IDE) and uses thereof
US10174363B2 (en) * 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
KR101646610B1 (ko) * 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
EP3314261B1 (de) * 2015-06-26 2019-09-18 Konica Minolta Laboratory U.S.A., Inc. Schneller und hochempfindlicher bakteriennachweis
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2993785A1 (en) 2015-08-03 2017-02-09 Advanced Endovascular Therapeutics Novel coatings for medical devices
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US10449259B2 (en) 2015-10-02 2019-10-22 Cornell University Enzyme-responsive peptide nanofiber compositions and uses thereof
WO2017123383A2 (en) 2015-12-17 2017-07-20 Trustees Of Tufts College Silk-fibroin hydrogels, methods of forming, and uses thereof
US11198715B2 (en) 2016-07-22 2021-12-14 Massachusetts Institute Of Technology Selective Bfl-1 peptides
US11248313B2 (en) 2016-08-01 2022-02-15 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
US11466064B2 (en) 2016-08-26 2022-10-11 Dana-Farber Cancer Institute, Inc. Bcl-w polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss
US10369167B2 (en) 2016-11-01 2019-08-06 City Of Hope Continuously expressed therapeutic RNAs for targeted protein binding and methods for their use
AU2017378427A1 (en) 2016-12-14 2019-06-20 Ligandal, Inc. Methods and compositions for nucleic acid and protein payload delivery
WO2019086517A1 (en) * 2017-10-31 2019-05-09 Roche Diagnostics Gmbh Improved magnetic particles and uses thereof
EP3728625A1 (de) * 2017-12-19 2020-10-28 3M Innovative Properties Company Zusammensetzungen und verfahren zur detektion von mikroorganismen
US11674136B2 (en) 2018-02-09 2023-06-13 President And Fellows Of Harvard College DNA-templated macrocycle library
US11918315B2 (en) 2018-05-03 2024-03-05 Pulse Therapeutics, Inc. Determination of structure and traversal of occlusions using magnetic particles
US11286299B2 (en) 2018-09-17 2022-03-29 Massachusetts Institute Of Technology Peptides selective for Bcl-2 family proteins
EP3861337B1 (de) 2018-10-01 2024-01-24 Kemira Oyj Verfahren zum bestimmen der konzentration von polyelektrolyten und phosphonaten
CN109444406A (zh) * 2018-11-09 2019-03-08 深圳市众循精准医学研究院 定量检测标志物cyfra21-1的试纸条及其制备方法和检测方法
CN109521194B (zh) * 2018-11-30 2023-03-31 暨南大学 DNA免疫吸附剂在制备抗ds-DNA抗体检测试剂中的应用
CN110878336B (zh) * 2019-11-18 2022-06-14 大连理工大学 一种基于Fe3O4@C纳米颗粒的miRNA光学传感检测方法
US20230355811A1 (en) * 2020-09-28 2023-11-09 University Of Florida Research Foundation, Inc. Compositions including magnetic nanoparticles and methods of using and making the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
US4661408A (en) 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
US5091206A (en) 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
JP3413415B2 (ja) * 1994-04-29 2003-06-03 セラディン インコーポレイテッド イムノアッセイ試薬およびそれを用いたイムノアッセイ法
DE69636553T2 (de) * 1995-07-07 2007-05-31 Toyo Boseki K.K. Nukleinsäuren bindender magnetischer Träger und Verfahren für die Nukleinsäureisolierung unter dessen Verwendung
AU7685498A (en) 1997-05-14 1998-12-08 Weixin Tang Fully-coated, uniform-sized metallic particles
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
CA2384429A1 (en) 1999-09-14 2001-03-22 Michael K. Bahr Magnetic nanoparticles having biochemical activity, method for the production thereof and their use
AU2001250937A1 (en) * 2000-03-22 2001-10-03 Quantum Dot Corporation Loop probe hybridization assay for polynucleotide analysis
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles

Also Published As

Publication number Publication date
US20040067503A1 (en) 2004-04-08
JP2005523027A (ja) 2005-08-04
EP1499895A4 (de) 2005-08-10
EP1499895B1 (de) 2008-05-07
HK1075698A1 (en) 2005-12-23
AU2003234196A1 (en) 2003-11-03
CN1662815A (zh) 2005-08-31
EP1499895A2 (de) 2005-01-26
WO2003089906A3 (en) 2004-01-22
DE60320780D1 (de) 2008-06-19
JP4381826B2 (ja) 2009-12-09
WO2003089906A2 (en) 2003-10-30
AU2003234196A8 (en) 2003-11-03
US7524630B2 (en) 2009-04-28
CA2482611A1 (en) 2003-10-30
CN100419426C (zh) 2008-09-17
RU2004133894A (ru) 2005-04-20

Similar Documents

Publication Publication Date Title
ATE394674T1 (de) Funktionalisierte nanopartikel und verwendungsverfahren
CN108884150A (zh) 突变孔
CN107075579A (zh) 生物化学激活的电子装置
WO2003106620A3 (en) NUCLEIC ACID SEQUENCING BY SIGNAL STRETCHING AND DATA INTEGRATION
EP2500440A3 (de) Mit Myokardinfarkt assoziierte genetische Polymorphismen, Nachweisverfahren und deren Verwendungen
ATE330038T1 (de) Nukleinsäure-biosensor
Velema et al. Fluorogenic templated reaction cascades for RNA detection
DK2725107T3 (da) DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
WO2001092572A1 (fr) Ensemble et procede de determination du type de hla
WO2004092331A3 (en) Composition and method for nucleic acid sequencing
EA201100001A3 (ru) Нуклеотиды и нуклеозиды и методы их использования в секвенировании днк
WO2004058990A3 (en) Genetic polymorphisms associated with stenosis, methods of detection and uses thereof
GEP20125384B (en) Representations of nucleotide sequences
WO2005087953A8 (en) Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
EP3040423A3 (de) Mikro-rna und verwendung davon
ATE505562T1 (de) Doppel-oligonukleotid- nukleinsäurenachweisverfahren
WO2004081187A8 (en) Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
Song et al. Trypsin-Amplified Aerolysin Nanopore Amplified Sandwich Assay for Attomolar Nucleic Acid and Single Bacteria Detection
Yukhet et al. Isothermal detection of canine blood parasite (Ehrlichia canis) utilizing recombinase polymerase amplification coupled with graphene oxide quenching-based pyrrolidinyl peptide nucleic acid
ATE445715T1 (de) Elektrokatalytischer nukleinsäurehybridisierungsnachweis
AR068529A1 (es) Uso de clec1b (lecitina tipo c de familia de dominio i, miembro b)
ATE516365T1 (de) Nukleinsäureamplifikationsprimer zum nachweis von cytokeratinen und untersuchungsverfahren mit verwendung der primer
WO2004101749A3 (en) Methods for amplification of nucleic acid sequences using staggered ligation
CA2569239A1 (en) Scintillation proximity assay for the activity of a dna or rna polymerase
Kimura et al. Fluorescence properties of 2-aminopurine–cytidine–7-deazaguanine (5′-ApC dz G-3′) trimer in B-and Z-DNA

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties