MX2015017274A - Moduladores del receptor del polipéptido insulina estabilizados. - Google Patents

Moduladores del receptor del polipéptido insulina estabilizados.

Info

Publication number
MX2015017274A
MX2015017274A MX2015017274A MX2015017274A MX2015017274A MX 2015017274 A MX2015017274 A MX 2015017274A MX 2015017274 A MX2015017274 A MX 2015017274A MX 2015017274 A MX2015017274 A MX 2015017274A MX 2015017274 A MX2015017274 A MX 2015017274A
Authority
MX
Mexico
Prior art keywords
xaa
insulin receptor
receptor modulators
stabilized polypeptide
polypeptide
Prior art date
Application number
MX2015017274A
Other languages
English (en)
Inventor
HILINSKI Gerard
Yue Liang Rebecca
L Verdine Gregory
Alice Nagel Yvonne
Zhou Minyun
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of MX2015017274A publication Critical patent/MX2015017274A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan aquí polipéptidos de a-CT estabilizados compuestos por un segmento alfa-helicoidal y en donde el polipéptido es de Fórmula (I-1) o Fórmula (I-2): Rf-[XAA)s-XA1-XA2-XA3-XA4-XA5-XA6-XA7-XA8-XA9-XA10-XA11-XA12-XA13 -XA14-[XAA]t-Re(I1) Rf-[XAA]s-XC1-XC2-XC3-XC4-XC5-XC6-XC7-XC8-XC9- XC10-XC11-XC12-XC13-XC14-XC15-XC16-XC17-XC18-XC19-XC20-[XAA]t-Re (I-2) en donde el polipéptido de a-CT se une al receptor de insulina y en el que el polipéptido de a-CT incluye al menos una grapa (es decir, dos aminoácidos entrelazados) y/o al menos una sutura (es decir, tres aminoácidos entrelazados); además se proporcionan análogos de insulina incluyendo los polipéptidosa-CT engrapados o cosidos, sus composiciones farmacéuticas, métodos de uso, por ejemplo, métodos de tratamiento de una condición diabética o sus complicaciones.
MX2015017274A 2013-06-14 2014-06-13 Moduladores del receptor del polipéptido insulina estabilizados. MX2015017274A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361835242P 2013-06-14 2013-06-14
PCT/US2014/042329 WO2014201370A1 (en) 2013-06-14 2014-06-13 Stabilized polypeptide insulin receptor modulators

Publications (1)

Publication Number Publication Date
MX2015017274A true MX2015017274A (es) 2016-08-04

Family

ID=51134430

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015017274A MX2015017274A (es) 2013-06-14 2014-06-13 Moduladores del receptor del polipéptido insulina estabilizados.

Country Status (12)

Country Link
US (1) US10227390B2 (es)
EP (1) EP3008081B1 (es)
JP (1) JP2016523241A (es)
KR (1) KR20160019547A (es)
CN (1) CN105492460A (es)
AU (2) AU2014278005B2 (es)
BR (1) BR112015031277A2 (es)
CA (1) CA2915354A1 (es)
HK (1) HK1223945A1 (es)
IL (1) IL243088B (es)
MX (1) MX2015017274A (es)
WO (1) WO2014201370A1 (es)

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ES2610531T3 (es) 2007-03-28 2017-04-28 President And Fellows Of Harvard College Polipéptidos cosidos
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MX362492B (es) 2012-02-15 2019-01-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos.
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
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KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
EP3294318A4 (en) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
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KR102003904B1 (ko) * 2016-08-17 2019-07-25 연세대학교 산학협력단 안정화된 알파-헬릭스 이차 구조를 갖는 펩타이드-고분자 결합체 제조방법 및 이를 이용해 제조된 펩타이드-고분자 결합체
KR102658844B1 (ko) * 2017-07-19 2024-04-17 토쿠시마 대학 펩티드 유도체 및 약학적 조성물
WO2019051327A2 (en) 2017-09-07 2019-03-14 Fog Pharmaceuticals, Inc. BETA CATENIN FUNCTIONALIZATION AGENTS AND ASSOCIATED METHODS
US11496462B2 (en) * 2017-11-29 2022-11-08 Jpmorgan Chase Bank, N.A. Secure multifactor authentication with push authentication
US11345725B2 (en) 2019-09-16 2022-05-31 Research Foundation Of The City University Of New York Bis-thioether stapled peptides as inhibitors of PRC2 function
EP4238979A4 (en) * 2020-10-30 2024-09-25 Xeno Interface Inc CROSS-LINKED BETA-STRAND PEPTIDE
CN113527416A (zh) * 2021-08-11 2021-10-22 南开大学 一种硝基还原酶响应氨基酸及肿瘤乏氧荧光探针的制备方法

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KR20160019547A (ko) 2016-02-19
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CA2915354A1 (en) 2014-12-18
US20160215036A1 (en) 2016-07-28
CN105492460A (zh) 2016-04-13
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IL243088B (en) 2018-12-31
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