MX2015015722A - Formulaciones estables de dominios variables sencillos de inmunoglobulina y usos de las mismas. - Google Patents
Formulaciones estables de dominios variables sencillos de inmunoglobulina y usos de las mismas.Info
- Publication number
- MX2015015722A MX2015015722A MX2015015722A MX2015015722A MX2015015722A MX 2015015722 A MX2015015722 A MX 2015015722A MX 2015015722 A MX2015015722 A MX 2015015722A MX 2015015722 A MX2015015722 A MX 2015015722A MX 2015015722 A MX2015015722 A MX 2015015722A
- Authority
- MX
- Mexico
- Prior art keywords
- variable domains
- single variable
- immunoglobulin single
- formulations
- stable
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 3
- 102000018358 immunoglobulin Human genes 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108010047303 von Willebrand Factor Proteins 0.000 abstract 2
- 102100036537 von Willebrand factor Human genes 0.000 abstract 2
- 229960001134 von willebrand factor Drugs 0.000 abstract 2
- 230000006866 deterioration Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a formulaciones estables de polipéptidos, por ejemplo dominios variables sencillos de inmunoglobulina, en particular dominios variables sencillos de inmunoglobulina dirigidos contra el Factor de von Willebrand (vWF). La invención proporciona formulaciones las cuales son estables durante el almacenamiento por periodos prolongados de tiempo y sobre un intervalo amplio de temperaturas. Las formulaciones de la invención aseguran una estabilidad alta del polipéptido, permitiendo ciclos de congelación-descongelación múltiples sin deterioro químico o físico, y proporcionan estabilidad con relación a la tensión mecánica, tal como tensión por sacudida, corte o agitación. Son adecuadas para preparaciones de diagnóstico y farmacéuticas y compatibles con diluyentes farmacéuticamente aceptables.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361824523P | 2013-05-17 | 2013-05-17 | |
PCT/EP2014/060107 WO2014184352A1 (en) | 2013-05-17 | 2014-05-16 | Stable formulations of immunoglobulin single variable domains and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015015722A true MX2015015722A (es) | 2016-03-16 |
MX364664B MX364664B (es) | 2019-05-03 |
Family
ID=49304267
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015015722A MX364664B (es) | 2013-05-17 | 2014-05-16 | Formulaciones estables de dominios variables sencillos de inmunoglobulina y usos de las mismas. |
MX2019005269A MX2019005269A (es) | 2013-05-17 | 2015-11-13 | Formulaciones estables de dominios variables sencillos de inmunoglobulina y usos de las mismas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005269A MX2019005269A (es) | 2013-05-17 | 2015-11-13 | Formulaciones estables de dominios variables sencillos de inmunoglobulina y usos de las mismas. |
Country Status (25)
Country | Link |
---|---|
US (2) | US10035862B2 (es) |
EP (2) | EP3511018B1 (es) |
JP (2) | JP6433986B2 (es) |
KR (1) | KR102166399B1 (es) |
CN (3) | CN105339003B (es) |
AU (3) | AU2014267222B2 (es) |
BR (1) | BR112015028411B1 (es) |
CA (1) | CA2912670A1 (es) |
CY (1) | CY1122090T1 (es) |
DK (1) | DK2996720T3 (es) |
ES (2) | ES2731922T3 (es) |
HK (1) | HK1218258A1 (es) |
HR (1) | HRP20190954T1 (es) |
HU (1) | HUE044392T2 (es) |
LT (1) | LT2996720T (es) |
MX (2) | MX364664B (es) |
NL (1) | NL1040254C2 (es) |
PH (1) | PH12015502591A1 (es) |
PL (2) | PL2996720T3 (es) |
PT (2) | PT2996720T (es) |
RS (1) | RS58857B1 (es) |
RU (1) | RU2671977C2 (es) |
SI (1) | SI2996720T1 (es) |
TR (1) | TR201908663T4 (es) |
WO (1) | WO2014184352A1 (es) |
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NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
AU2015366284B2 (en) | 2014-12-19 | 2021-07-22 | Ablynx N.V. | Cysteine linked nanobody dimers |
CN105833255A (zh) * | 2016-03-23 | 2016-08-10 | 兆科药业(合肥)有限公司 | 抗血小板溶栓素在制备治疗血栓性血小板减少性紫癜的药物中的应用 |
GB201612043D0 (en) | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
US20180296652A1 (en) * | 2016-11-02 | 2018-10-18 | Polaris Group | Formulations of pegylated arginine deiminase |
US11999797B2 (en) | 2018-02-06 | 2024-06-04 | Ablynx N.V. | Methods of treating initial episode of TTP with immunoglobulin single variable domains |
EP3818010A4 (en) | 2018-07-03 | 2022-08-17 | Fennec Pharmaceuticals, Inc. | ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF |
US20210317189A1 (en) * | 2018-09-05 | 2021-10-14 | Ventria Bioscience Inc. | Formulations of immunoglobulin a |
US20210355233A1 (en) * | 2018-10-10 | 2021-11-18 | Astellas Pharma Inc. | Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex |
CN110564841A (zh) * | 2019-09-19 | 2019-12-13 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | 脑缺血相关基因作为缺血性卒中行为学特征分析的生物标记的应用 |
CN110624105B (zh) * | 2019-09-24 | 2021-06-11 | 苏州大学 | 血管性血友病因子的结构敏感多肽抗原的序列 |
JP7502861B2 (ja) | 2019-12-27 | 2024-06-19 | 旭化成株式会社 | 標的物質と両親媒性高分子との複合体の形成反応の反応温度の評価方法 |
CN113908254B (zh) * | 2021-10-19 | 2024-05-28 | 山西锦波生物医药股份有限公司 | 一种干粉吸入剂及其制备方法和用途 |
CN115850493B (zh) * | 2022-11-08 | 2024-03-12 | 江苏耀海生物制药有限公司 | 一种二价纳米抗体Cablivi的分离纯化方法 |
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US20120225072A1 (en) * | 2011-03-02 | 2012-09-06 | Ablynx N.V. | Stable formulations of immunoglobulin single variable domains and uses thereof |
NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
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2013
- 2013-06-14 NL NL1040254A patent/NL1040254C2/en active
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2014
- 2014-05-16 CN CN201480034630.9A patent/CN105339003B/zh active Active
- 2014-05-16 HU HUE14727433 patent/HUE044392T2/hu unknown
- 2014-05-16 RU RU2015154214A patent/RU2671977C2/ru active
- 2014-05-16 BR BR112015028411-6A patent/BR112015028411B1/pt active IP Right Grant
- 2014-05-16 AU AU2014267222A patent/AU2014267222B2/en active Active
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