JP2011525128A5 - - Google Patents

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JP2011525128A5
JP2011525128A5 JP2011514184A JP2011514184A JP2011525128A5 JP 2011525128 A5 JP2011525128 A5 JP 2011525128A5 JP 2011514184 A JP2011514184 A JP 2011514184A JP 2011514184 A JP2011514184 A JP 2011514184A JP 2011525128 A5 JP2011525128 A5 JP 2011525128A5
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composition
calcium
transglutaminase
gelatin
amount
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JP2011514184A
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JP5450612B2 (ja
JP2011525128A (ja
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Priority claimed from PCT/IB2009/052605 external-priority patent/WO2009153750A2/en
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Publication of JP2011525128A5 publication Critical patent/JP2011525128A5/ja
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JP2011514184A 2008-06-18 2009-06-18 改良された架橋組成物 Active JP5450612B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12932208P 2008-06-18 2008-06-18
US61/129,322 2008-06-18
PCT/IB2009/052605 WO2009153750A2 (en) 2008-06-18 2009-06-18 Improved cross-linked compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013265507A Division JP5857030B2 (ja) 2008-06-18 2013-12-24 改良された架橋組成物

Publications (3)

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JP2011525128A JP2011525128A (ja) 2011-09-15
JP2011525128A5 true JP2011525128A5 (https=) 2013-04-18
JP5450612B2 JP5450612B2 (ja) 2014-03-26

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JP2011514184A Active JP5450612B2 (ja) 2008-06-18 2009-06-18 改良された架橋組成物
JP2013265507A Active JP5857030B2 (ja) 2008-06-18 2013-12-24 改良された架橋組成物

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US (3) US8367388B2 (https=)
EP (2) EP2487206A3 (https=)
JP (2) JP5450612B2 (https=)
CN (2) CN102124058B (https=)
AU (1) AU2009261559B2 (https=)
CA (1) CA2728187C (https=)
IL (1) IL209983A (https=)
WO (1) WO2009153750A2 (https=)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3029261B2 (ja) 1988-08-30 2000-04-04 キヤノン株式会社 通信システム
BRPI0718328A2 (pt) 2006-12-15 2011-10-11 Lifebond Ltd composição, curativo hemostático e dispositivo médico para a inserção em um corpo de um ser humano ou de um mamìfero inferior
EP2487206A3 (en) 2008-06-18 2012-11-28 Lifebond Ltd Cross-linkable gelatin-based compositions
EP2239569A1 (en) 2009-04-09 2010-10-13 Lophius Biosciences GmbH Method for polypeptide transfer into cells
WO2011077388A1 (en) 2009-12-22 2011-06-30 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
US8961544B2 (en) 2010-08-05 2015-02-24 Lifebond Ltd. Dry composition wound dressings and adhesives comprising gelatin and transglutaminase in a cross-linked matrix
JP5594633B2 (ja) * 2010-10-05 2014-09-24 独立行政法人物質・材料研究機構 2成分系組織接着剤及びその製造方法
DE102011101995A1 (de) * 2011-05-19 2012-11-22 Sartorius Stedim Biotech Gmbh Verfahren zur Auftrennung eines Gemisches aus einem Protein und seinem Reaktionsprodukt mit einem Polyalkylenglykol
CN102349861B (zh) * 2011-10-13 2013-03-27 四川大学 一种酚酸类改性胶原蛋白面膜及其制备方法
EP2814511B1 (en) * 2012-02-16 2021-10-20 Active Healing Bio Medical Ltd. Formulations and kits for forming bioadhesive matrices
US11062258B2 (en) 2012-02-24 2021-07-13 Netclearance Systems, Inc. Automated logistics management using proximity events
US20130224712A1 (en) * 2012-02-24 2013-08-29 Bradford L. Day Medical training kits and methods to simulate treatment of uncontrolled hemorrhage
US10586251B2 (en) * 2012-02-24 2020-03-10 Netclearance Systems, Inc. Consumer interaction using proximity events
US11037196B2 (en) 2012-02-24 2021-06-15 Netclearance Systems, Inc. Interactive advertising using proximity events
CN102727929B (zh) * 2012-06-12 2014-04-02 华东师范大学 一种止血剂及其制备方法和应用
EP2695606A1 (en) * 2012-08-09 2014-02-12 ETH Zürich Liposome composition for peritoneal dialysis
CN103263688B (zh) * 2013-05-10 2014-07-30 华东师范大学 一种明胶组合物及其制备方法和应用
CN103360613B (zh) * 2013-06-09 2015-12-09 武汉理工大学 一种采用微生物转谷氨酰胺酶修饰的明胶/纳米银复合材料及其制备方法和应用
RU2667748C1 (ru) * 2013-11-25 2018-09-24 Нестек Са Жевательная пищевая композиция с разбухшей текстурой
US20150359857A1 (en) * 2014-04-07 2015-12-17 Biomedica Management Corporation Aerosolized fibrin hemostat
CN107257802B (zh) * 2014-12-19 2021-11-23 豪夫迈·罗氏有限公司 转谷氨酰胺酶底物的鉴别及其用途
WO2016130861A1 (en) * 2015-02-13 2016-08-18 Medterials, Inc Composition and method for use of energy activated wound dressing
EP3277307B1 (en) * 2015-04-03 2021-12-08 Biochange Ltd. Powder compositions for generating cross-linked protein foams and methods of using thereof
CN105664232B (zh) * 2015-12-30 2019-04-12 深圳清华大学研究院 止血材料及其制备方法和应用
WO2017170487A1 (ja) * 2016-03-28 2017-10-05 富士フイルム株式会社 製剤、製剤用部材およびそれらの製造方法
CN109475400A (zh) 2016-05-09 2019-03-15 生命连结有限公司 基于网状补片的原位可交联组合物
CN109952341A (zh) * 2016-06-17 2019-06-28 洛斯安第斯大学 衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途
JP6904550B2 (ja) * 2016-11-04 2021-07-21 青葉化成株式会社 食品用品質改良材の製造方法
CN106561784A (zh) * 2016-11-14 2017-04-19 扬州大学 一种天然肠衣的超高压生产工艺
US11151534B2 (en) 2016-11-29 2021-10-19 Netclearance Systems, Inc. Consumer interaction module for point-of-sale (POS) systems
US11334889B2 (en) 2016-11-29 2022-05-17 Netclearance Systems, Inc. Mobile ticketing based on proximity
JP7446049B2 (ja) * 2016-12-28 2024-03-08 ミヨシ油脂株式会社 粉末油脂
EP3573674A1 (en) 2017-01-30 2019-12-04 LifeCell Corporation Transglutaminase treated products
EP3687560A4 (en) 2017-09-29 2021-06-23 Bard Shannon Limited COMPOSITION AND METHOD OF CONTROLLED DRUG RELEASE FROM TISSUE
KR20210062589A (ko) * 2017-10-04 2021-05-31 바이오-체인지 엘티디. 가교 결합된 단백질 발포체 및 다가 세포 스캐폴드 사용 방법
JP6960862B2 (ja) * 2018-01-15 2021-11-05 日本バイリーン株式会社 ゼラチン溶液と該ゼラチン溶液からなる紡糸液、および、該紡糸液を用いた繊維集合体の製造方法と該ゼラチン溶液を用いたフィルムならびに複合体の製造方法
WO2019182123A1 (ja) * 2018-03-23 2019-09-26 味の素株式会社 トランスグルタミナーゼを含有する液体製剤
US10752772B1 (en) * 2018-03-28 2020-08-25 United States Of America As Represented By The Secretary Of The Navy Marine biodegradable composition for 3-D printing
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
CN109295137B (zh) * 2018-10-17 2020-11-06 四川大学 一种多步连续酶催化微纤维胶原交联改性的方法
BR112021011936A2 (pt) * 2018-12-18 2021-09-08 International Flavors & Fragrances Inc. Processo para preparar uma composição de microcápsula, composição de microcápsula, e, produto de consumo
EP3698644A1 (en) * 2019-02-20 2020-08-26 Kl-Teho Oy A fishing bait, a mouldable composition for manufacturing the fishing bait, a method for manufacturing the fishing bait and a use of the mouldable composition
US20200338377A1 (en) 2019-04-23 2020-10-29 University Of Rhode Island Board Of Trustees Polymer immobilization matrix for containment of hazardous materials and methods of using the same
CN111334934B (zh) * 2020-03-16 2021-11-19 南通大学 一种壳聚糖交联抗菌纳米纤维膜及其制备方法
BR112022019139A2 (pt) * 2020-03-24 2022-11-08 Univ Columbia Fibras têxteis biodegradáveis com cor e propriedades inerentes
CN112870453B (zh) * 2020-07-07 2022-01-07 深圳市第二人民医院(深圳市转化医学研究院) 一种明胶-iii型胶原蛋白水凝胶以及制备方法和应用
JP2022035989A (ja) * 2020-08-20 2022-03-04 青葉化成株式会社 液状医療材料
EP3957338A1 (en) 2020-08-20 2022-02-23 Aobakasei Kabushiki Kaisha Liquid medical material
CN112481711B (zh) * 2020-11-20 2023-06-16 齐鲁工业大学 一种静电纺丝制备抗菌明胶膜的方法
CN115400231A (zh) * 2021-05-27 2022-11-29 中国科学院过程工程研究所 一种导电医用粘合胶及其制备方法和应用
WO2023287469A1 (en) * 2021-07-16 2023-01-19 The Regents Of The University Of California Reusable environmentally friendly food cooling technology
JP2023045488A (ja) * 2021-09-22 2023-04-03 国立大学法人 東京大学 ゼラチンを主成分とする導電性ゲル組成物
KR102882918B1 (ko) * 2021-11-29 2025-11-07 연세대학교 산학협력단 배양육 제조용 스캐폴드 조립체
US20250295830A1 (en) * 2022-02-07 2025-09-25 The American University In Cairo Hemostatic sponge comprising gelatin and chitosan
CN119790136A (zh) * 2022-08-04 2025-04-08 三荣源F.F.I.株式会社 细胞培养用的多孔支架及其制造方法
CN115554234A (zh) * 2022-10-11 2023-01-03 湖南理工学院 一种pH响应型多肽明胶杂化水凝胶的制备方法
CN118206089B (zh) * 2024-03-20 2024-11-26 上海倍尔康生物医学科技有限公司 一种羟基磷灰石微球及其制备方法和应用
CN119119614A (zh) * 2024-09-29 2024-12-13 云南浩翔包装制品有限公司 一种高强度聚乙烯牛奶瓶盖及其制备工艺
KR102822252B1 (ko) * 2025-04-14 2025-06-19 주식회사 바이오비쥬 키토산을 이용한 창상피복용 조성물 및 이의 제조방법

Family Cites Families (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719145A (en) 1955-09-27 Process for effecting complex
US1873580A (en) 1932-08-23 Dustries limited
US1394654A (en) 1920-12-27 1921-10-25 Donald K Tressler Manufacture of liquid glue
US1844679A (en) 1925-12-07 1932-02-09 Glue Res Corp Glue solution and process of manufacturing same
US1950483A (en) 1931-07-13 1934-03-13 Swift & Co Preparation of glue and the product thereof
US2048499A (en) 1934-04-07 1936-07-21 Deutsche Hydrierwerke Ag Gelatine solutions
US2166074A (en) 1937-04-09 1939-07-11 Sharp & Dohme Inc Gelatinous colloids
US2126305A (en) 1937-06-23 1938-08-09 Eastman Kodak Co Dispersion of gelatin
US2417713A (en) 1940-03-19 1947-03-18 Ilford Ltd Production of gelatin layers
US2398004A (en) 1943-07-20 1946-04-09 Eastman Kodak Co Controlling the isoelectric point of gelatin
US2558065A (en) 1949-05-03 1951-06-26 Linwood F Tice Method of preparing solutions of gelatin in polyhydric alcohols
US2658001A (en) 1950-09-26 1953-11-03 Swift & Co Liquid glue composition
US2803548A (en) 1955-02-07 1957-08-20 Louis Milani Foods Inc Method of making gelatin-containing food preparations which dissolve at room temperature and gel at room temperature
US3220845A (en) 1963-04-10 1965-11-30 Keuffel & Esser Co Epoxy resin impregnated photo base and method of preparation
US3600482A (en) 1970-01-15 1971-08-17 Monsanto Res Corp Method of forming a mat of fibrous gelatin
US3939001A (en) 1973-06-08 1976-02-17 General Foods Corporation Spoonable frozen gelatin dessert concentrate
US3988479A (en) 1975-03-26 1976-10-26 Stephan John T Gelled proteinaceous fish bait and process of preparing same
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
DE2612726C3 (de) 1976-03-25 1979-03-15 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisierte Urease
JPS5832576B2 (ja) 1976-10-28 1983-07-14 協和醗酵工業株式会社 ゼラチンの改質法
SE415804B (sv) 1978-06-21 1980-10-27 Nils Johannes Baecklund Sett att medelst rontgenstralning meta halten eller mengden av ett forutbestemt grundemne i ett prov, samt anordning for utforande av settet
US4426443A (en) 1981-08-27 1984-01-17 Dynagel, Incorporated Preparation of hydrolyzed collagen-containing products from non-gelled, liquid hydrolyzed collagen concentrate and gelled products prepared therefrom
US4527906A (en) 1982-12-27 1985-07-09 Venda Jezbera Digital menstrual cycle indicator
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
CA1202904A (en) 1983-11-21 1986-04-08 Brian G. Sparkes Chitosan based wound dressing materials
US4711848A (en) 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
US4605513A (en) 1984-08-08 1986-08-12 Eli Lilly And Company Process for inhibiting peptide carbamylation
JPS61240963A (ja) 1985-04-18 1986-10-27 ユニチカ株式会社 創傷被覆保護材
JPH0779694B2 (ja) 1985-07-09 1995-08-30 カドラント バイオリソ−シズ リミテツド 蛋白質および同類品の保護
FR2586030B1 (fr) 1985-08-07 1987-12-18 Rousselot Cie Gelatine a proprietes ameliorees et son procede de preparation par pelliculage avec une gelatine hydrolysee
JPS6323670A (ja) 1986-04-25 1988-01-30 バイオ−ポリマ−ズ インコ−ポレ−テツド 接着・被覆組成物とその使用方法
EP0302953A1 (de) 1987-08-11 1989-02-15 Deutsche Gelatine-Fabriken Stoess AG Verfahren zur Herrstellung von Formkörpern aus Kollagen und Kollagenabbauprodukten
US4952618A (en) 1988-05-03 1990-08-28 Minnesota Mining And Manufacturing Company Hydrocolloid/adhesive composition
US4837379A (en) 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
GB8813161D0 (en) 1988-06-03 1988-07-06 Unilever Plc Emulsions
US4948540A (en) 1988-08-01 1990-08-14 Semex Medical, Inc. Method of preparing collagen dressing sheet material
JPH02255888A (ja) * 1988-11-08 1990-10-16 Nippon Oil & Fats Co Ltd 架橋ゼラチンゲル
US4931501A (en) 1989-10-20 1990-06-05 Air Products And Chemicals, Inc. Modified poly(vinyl alcohol) containing morpholinoalkylether groups
DE4007668A1 (de) 1990-03-10 1991-09-12 Beiersdorf Ag Hydrogelschaeume und verfahren zu deren herstellung
US5209776A (en) 1990-07-27 1993-05-11 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5059636A (en) 1990-11-13 1991-10-22 Grenga Paul A Tire sealant composition
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5480644A (en) 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
WO1993020837A1 (fr) * 1992-04-21 1993-10-28 Ajinomoto Co., Inc. Remede contre les plaies
IL105529A0 (en) 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
CA2137275A1 (en) 1992-06-03 1993-12-09 Richard L. Eckert Bandage for continuous application of biologicals
US5433943A (en) 1992-12-21 1995-07-18 Osipow; Lloyd I. Deodorant and/or antiperspirant compositions
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
GB9313501D0 (en) 1993-06-30 1993-08-11 Nycomed Imaging As Improvements in or relating to polymer materials
US5939385A (en) 1993-08-13 1999-08-17 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5428014A (en) 1993-08-13 1995-06-27 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5487895A (en) 1993-08-13 1996-01-30 Vitaphore Corporation Method for forming controlled release polymeric substrate
US5441193A (en) 1993-09-23 1995-08-15 United States Surgical Corporation Surgical fastener applying apparatus with resilient film
US5503638A (en) 1994-02-10 1996-04-02 Bio-Vascular, Inc. Soft tissue stapling buttress
JP3433302B2 (ja) 1994-02-21 2003-08-04 株式会社ニチロ 新規ゲル化素材及びその製造法並びにこれを用いたゲル化食品とその製造法
US6704210B1 (en) 1994-05-20 2004-03-09 Medtronic, Inc. Bioprothesis film strip for surgical stapler and method of attaching the same
NZ291414A (en) 1994-08-26 1998-05-27 Novo Nordisk As Microbial transglutaminases and methods of production using fungi and dna constructs
US5931165A (en) 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
EP0745670B1 (en) 1994-10-11 2004-06-23 Ajinomoto Co., Inc. Stabilized transglutaminase and enzymatic preparation containing the same
FR2726571B1 (fr) 1994-11-03 1997-08-08 Izoret Georges Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique
FI972443A7 (fi) 1994-12-07 1997-06-09 Novozymes As Polypeptidi, jonka allergeenisuus on vähentynyt
JP4223548B2 (ja) 1994-12-07 2009-02-12 ジ・アメリカン・ナショナル・レッド・クロス 補足または非補足組織シーラント、それらの製法および使用
CA2208730A1 (en) 1995-01-19 1996-07-25 Novo Nordisk A/S Transglutaminases from oomycetes
JP3669390B2 (ja) 1995-02-09 2005-07-06 味の素株式会社 バチルス属細菌由来のトランスグルタミナーゼ
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
WO1996040791A1 (en) 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
US5810855A (en) 1995-07-21 1998-09-22 Gore Enterprise Holdings, Inc. Endoscopic device and method for reinforcing surgical staples
US5702409A (en) 1995-07-21 1997-12-30 W. L. Gore & Associates, Inc. Device and method for reinforcing surgical staples
AU7398196A (en) 1995-10-11 1997-04-30 Fusion Medical Technologies, Inc. Device and method for sealing tissue
JPH09122227A (ja) 1995-10-31 1997-05-13 Bio Eng Lab:Kk 医用材料およびその製造方法
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
JP3545148B2 (ja) * 1996-01-08 2004-07-21 味の素株式会社 食用マイクロカプセル及びそれを含有する食品
DE19604706A1 (de) 1996-02-09 1997-08-14 Merck Patent Gmbh Vernetzungsprodukte von Aminogruppen-haltigen Biopolymeren
AU2052197A (en) 1996-02-20 1997-09-02 Fusion Medical Technologies, Inc. Compositions and methods for sealing tissue and preventing post-surgical adhesions
CZ318998A3 (cs) 1996-04-04 1999-09-15 Baxter Aktiengesellschaft Hemostatická houba na bázi kolagenu, způsob její přípravy, kryt na ránu a kit k přípravě tohoto krytu
US6132765A (en) 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US5834232A (en) 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
CA2251129A1 (en) 1996-05-03 1997-11-13 Innogenetics N.V. New medicaments containing gelatin cross-linked with oxidized polysaccharides
JP3407599B2 (ja) 1996-07-01 2003-05-19 味の素株式会社 接着用酵素製剤及び接着食品の製造法
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5752965A (en) 1996-10-21 1998-05-19 Bio-Vascular, Inc. Apparatus and method for producing a reinforced surgical fastener suture line
JP2001511162A (ja) 1997-02-06 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 付加され、そして/又は除去された付着基を有するポリペプチド−ポリマー結合体
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
DE19882746T1 (de) 1997-04-03 2001-10-18 California Inst Of Techn Enzymvermittelte Modifikation von Fibrin für das Gewebs-Engineering
WO1998051711A1 (fr) 1997-05-14 1998-11-19 Japan As Represented By Director General Of National Institute Of Sericultural And Entomological Science Ministry Of Agriculture, Forestry And Fisherries Perles de chitine, perles de chitosane, leur procede de production, vehicule comprenant lesdites perles, et procede de preparation d'une spore de microsporidie
US6458386B1 (en) 1997-06-03 2002-10-01 Innogenetics N.V. Medicaments based on polymers composed of methacrylamide-modified gelatin
US6015474A (en) 1997-06-20 2000-01-18 Protein Polymer Technologies Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants
ATE375387T1 (de) 1997-06-25 2007-10-15 Novozymes As Modifiziertes polypeptid
ZA987019B (en) 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
US6190896B1 (en) 1997-11-14 2001-02-20 Bassam M. Fraij Active human cellular transglutaminase
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
WO1999036570A2 (en) 1998-01-20 1999-07-22 Pericor Science Inc Transglutaminase linkage of agents to tissue
US6136341A (en) 1998-02-27 2000-10-24 Petito; George D. Collagen containing tissue adhesive
US6107401A (en) 1998-03-26 2000-08-22 Air Products And Chemicals, Inc. Process for producing amine functional derivatives of poly (vinyl alcohol)
JP4137224B2 (ja) 1998-03-31 2008-08-20 天野エンザイム株式会社 酵素による蛋白質の架橋法
US6399117B1 (en) * 1998-04-08 2002-06-04 Nutreco Aquaculture Research Centre A/S Method for the modification of protein structure in finish shaped feed pellets, balls or the like in order to achieve shape stability, and feed mass made in accordance with the method
US6428978B1 (en) 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
JP4480270B2 (ja) 1998-05-19 2010-06-16 ジ・アメリカン・ナショナル・レッド・クロス 止血サンドウィッチ包帯
US20020015724A1 (en) 1998-08-10 2002-02-07 Chunlin Yang Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
DE19838189A1 (de) 1998-08-24 2000-03-02 Basf Ag Stabile pulverförmige Vitamin- und Carotinoid-Zubereitungen und Verfahren zu deren Herstellung
US7241730B2 (en) 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
FR2784296B1 (fr) 1998-09-18 2001-01-05 Imedex Biomateriaux Dispositif pour la formulation et la delivrance d'un melange, notamment pour l'application chirurgicale de ce melange
AU6078899A (en) 1998-10-13 2000-05-01 Novozymes A/S A modified polypeptide with reduced immune response
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
CA2356597A1 (en) 1998-12-28 2000-07-13 Ajinomoto Co., Inc. Process for producing transglutaminase
US6610043B1 (en) 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
CA2345779A1 (en) 1999-08-27 2001-03-08 Department Of National Defence Hydrogel wound dressing containing liposome-encapsulated therapeutic agent
WO2001028515A1 (en) 1999-10-22 2001-04-26 Líf-Hlaup ehf. Bio-Gels Pharmaceuticals Inc. Pharmaceutical composition for treatment of mucosal epithelial ulceration and/or erosion
US20030035786A1 (en) 1999-11-04 2003-02-20 Medtronic, Inc. Biological tissue adhesives, articles, and methods
US6992172B1 (en) 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
US6425885B1 (en) 1999-12-20 2002-07-30 Ultradent Products, Inc. Hydraulic syringe
CA2403558A1 (en) 2000-03-23 2001-09-27 Merck & Co., Inc. Thrombin inhibitors
US6682760B2 (en) 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
JP2001329183A (ja) 2000-05-22 2001-11-27 Yuichi Mori ゲル化性組成物
US7108876B2 (en) 2001-01-25 2006-09-19 Nutricepts, Inc. Shaped cheese reconstruction with transglutaminase
US6565530B2 (en) 2001-02-28 2003-05-20 Scimed Life Systems, Inc. Immobilizing objects in the body
JP4051621B2 (ja) 2001-03-30 2008-02-27 味の素株式会社 接着用酵素製剤及び接着成形食品の製造方法。
WO2002085422A1 (en) 2001-04-25 2002-10-31 Eidgenössische Technische Hochschule Zürich Drug delivery matrices to enhance wound healing
US6656193B2 (en) 2001-05-07 2003-12-02 Ethicon Endo-Surgery, Inc. Device for attachment of buttress material to a surgical fastening device
ATE376410T1 (de) 2001-05-16 2007-11-15 Susanna Elizabeth Chalmers Wundverbände und wundbehandlungszusammensetzungen
EP1419187A4 (en) * 2001-06-01 2006-06-07 Shriners Hospitals Children COMPOSITIONS BASED ON POLYMER COMPOSITES
US8741335B2 (en) 2002-06-14 2014-06-03 Hemcon Medical Technologies, Inc. Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan
GB2377939B (en) 2001-07-26 2005-04-20 Johnson & Johnson Medical Ltd Apertured sheet materials
US8501165B2 (en) 2001-12-12 2013-08-06 Promethean Surgical Devices Llc In situ bonds
US6939358B2 (en) 2001-12-20 2005-09-06 Gore Enterprise Holdings, Inc. Apparatus and method for applying reinforcement material to a surgical stapler
JP4489437B2 (ja) 2002-02-21 2010-06-23 エンセル,インコーポレイテッド 表面コーティングとしての固定化生物活性ヒドロゲルマトリックス
WO2003074004A2 (en) 2002-03-01 2003-09-12 Szu-Yi Chou Method of producing antigens
US7101695B2 (en) 2002-03-01 2006-09-05 Szu-Yi Chou Method of producing transglutaminase having broad substrate activity
EP1494730B1 (en) 2002-03-22 2012-01-18 Kuros Biosurgery AG Composition for hard tissue augmentation
US7005143B2 (en) 2002-04-12 2006-02-28 3M Innovative Properties Company Gel materials, medical articles, and methods
WO2003088844A1 (en) 2002-04-15 2003-10-30 Cook Biotech Incorporated Apparatus and method for producing a reinforced surgical staple line
WO2003104313A1 (en) 2002-06-11 2003-12-18 Terminus Biotech Ab Porous gelatin material, gelatin structures, methods for preparation of the same and uses thereof
US20070082023A1 (en) 2002-06-14 2007-04-12 Hemcon Medical Technologies, Inc. Supple tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan
US20040106344A1 (en) 2002-06-28 2004-06-03 Looney Dwayne Lee Hemostatic wound dressings containing proteinaceous polymers
US6773156B2 (en) 2002-07-10 2004-08-10 Tah Industries, Inc. Method and apparatus for reducing fluid streaking in a motionless mixer
AU2002950340A0 (en) * 2002-07-23 2002-09-12 Commonwealth Scientific And Industrial Research Organisation Biodegradable polyurethane/urea compositions
DE60312525T2 (de) 2002-08-09 2007-12-06 Ottawa Health Research Institute, Ottawa Biosynthetische matrix und deren verwendung
DE10261126A1 (de) 2002-08-13 2004-03-04 Aventis Behring Gmbh Lagerungsstabile, flüssige Fibrinogen-Formulierung
US20060155234A1 (en) 2002-09-10 2006-07-13 American National Red Cross Hemostatic dressing
AU2003275289A1 (en) 2002-09-26 2004-04-19 University Of Maryland Baltimore County Polysaccharide-based polymers and methods of making the same
CN100448366C (zh) 2002-09-26 2009-01-07 味之素株式会社 酶制剂及用其生产食品的方法
WO2004028404A2 (en) 2002-09-30 2004-04-08 Fibrogen, Inc. Dry tissue sealant compositions
GB2393656B (en) 2002-10-01 2005-11-16 Johnson & Johnson Medical Ltd Enzyme-sensitive therapeutic wound dressings
WO2004042068A2 (en) * 2002-10-31 2004-05-21 Northwestern University Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation
US6863783B2 (en) 2002-11-14 2005-03-08 The Meow Mix Company Method of producing electrostatically charged gelatin
US7718556B2 (en) 2002-12-16 2010-05-18 Gunze Limited Medical film
WO2005051979A1 (en) 2003-02-21 2005-06-09 Akzo Nobel N.V. Prevention and/or delay of peptide/protein carbamylation in urea solutions utilizing non-ethylene diamine like compounds
JP2004283371A (ja) 2003-03-20 2004-10-14 Nagoya Industrial Science Research Inst 医用材料
US7019191B2 (en) 2003-03-25 2006-03-28 Ethicon, Inc. Hemostatic wound dressings and methods of making same
US6923996B2 (en) 2003-05-06 2005-08-02 Scimed Life Systems, Inc. Processes for producing polymer coatings for release of therapeutic agent
EP1628529A2 (en) 2003-05-30 2006-03-01 Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek Inducible release vehicles
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
US7186684B2 (en) 2003-08-07 2007-03-06 Ethicon, Inc. Hemostatic device containing a protein precipitate
US7316822B2 (en) * 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
WO2005055958A2 (en) 2003-12-09 2005-06-23 Promethean Surgical Devices Llc Improved surgical adhesive and uses therefor
US20080026444A1 (en) 2003-12-24 2008-01-31 Shionogi & Co., Ltd. Process For Producing Protein-Polymer Complex
US7109163B2 (en) 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
US20050209441A1 (en) 2004-03-22 2005-09-22 Lile Jackson D Process for promoting proper folding of human serum albumin using a human serum albumin ligand
DE102004024635A1 (de) * 2004-05-12 2005-12-08 Deutsche Gelatine-Fabriken Stoess Ag Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine
US20050271727A1 (en) 2004-06-07 2005-12-08 Callisyn Pharmaceuticals, Inc. Biodegradable and biocompatible crosslinked polymer hydrogel prepared from PVA and/or PEG macromer mixtures
US7468350B2 (en) 2004-06-16 2008-12-23 Pneumrx, Inc. Glue composition for lung volume reduction
CA2570261C (en) 2004-07-08 2014-06-10 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
JP4994230B2 (ja) 2004-07-08 2012-08-08 ヌームアールエックス・インコーポレーテッド 密封機能を備える肺装置
US20080241878A1 (en) 2004-08-12 2008-10-02 Johannes Wilhelmus Leonardus Boumans Method For Enzmatic Cross-Linking Of A Protein, Cross-Linked Protein Thus Obatained And Use Thereof
GB0420091D0 (en) * 2004-09-10 2004-10-13 Univ Nottingham Trent Medical implant materials
US20060100138A1 (en) 2004-11-10 2006-05-11 Olsen David R Implantable collagen compositions
FR2878533B1 (fr) * 2004-11-26 2007-04-27 Univ Cergy Pontoise Biomateriau capable d'effectuer successivement une transition solution/gel puis une transition gel/solution
JP2008529663A (ja) 2005-02-09 2008-08-07 チルドレンズ メディカル センター コーポレイション 組織回復のために流体を混合および供給するデバイス
US20080107703A1 (en) 2005-02-14 2008-05-08 Yasuhiko Tabata Hydrogel For Medical Use
US7485323B2 (en) 2005-05-31 2009-02-03 Gelita Ag Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions
MX2007015676A (es) 2005-06-15 2008-02-20 Novo Nordisk Healthcare Ag Conjugacion de la hormona de crecimiento mediada por transglutaminasa.
WO2007126411A2 (en) * 2005-07-28 2007-11-08 Carnegie Mellon University Biocompatible polymers and methods of use
CN100341944C (zh) * 2005-09-30 2007-10-10 中国科学院理化技术研究所 可食性包装膜及其制备方法和用途
DE102005054940A1 (de) 2005-11-17 2007-05-24 Gelita Ag Verbundmaterial, insbesondere für die medizinische Anwendung , und Verfahren zu dessen Herstellung
AU2006321913B2 (en) 2005-12-06 2012-08-02 Covidien Lp Biocompatible tissue sealants and adhesives
CA2573472A1 (en) 2006-01-23 2007-07-23 Tyco Healthcare Group Lp Biodegradable hemostatic compositions
US20070246505A1 (en) 2006-04-24 2007-10-25 Medical Ventures Inc. Surgical buttress assemblies and methods of uses thereof
KR20070104748A (ko) 2006-04-24 2007-10-29 박현진 어류 젤라틴 하드 캅셀용 필름 형성 조성물 및 이의제조방법
EP2021536B1 (en) 2006-04-24 2014-02-26 Coloplast A/S Non-woven structures produced by a non-toxic dry solvent spinning process
WO2007134118A2 (en) 2006-05-09 2007-11-22 Chulso Moon Protein based composition and methods of using same
DE102006033168A1 (de) 2006-07-10 2008-01-17 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung
DE102006033167A1 (de) * 2006-07-10 2008-01-24 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers
TWI436793B (zh) 2006-08-02 2014-05-11 巴克斯特國際公司 快速作用之乾密封膠及其使用和製造方法
JP2010512230A (ja) 2006-12-11 2010-04-22 プルーロームド インコーポレイテッド 灌流臓器止血法
BRPI0718328A2 (pt) * 2006-12-15 2011-10-11 Lifebond Ltd composição, curativo hemostático e dispositivo médico para a inserção em um corpo de um ser humano ou de um mamìfero inferior
US8133484B2 (en) 2006-12-15 2012-03-13 Lifebond Ltd Hemostatic materials and dressing
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
EP2125092A4 (en) 2007-02-22 2012-03-14 Pluromed Inc USE OF REVERSIBLE HEAT-SENSITIVE POLYMERS FOR FLOW CONTROL OF A BIOLOGICAL LIQUID AFTER MEDICAL USE
BRPI0814439B1 (pt) 2007-07-20 2018-12-11 Imaflex, Inc. filme de palha, filme para fumigação e/ou filme para propagação, seu processo de produção e seu uso
US8529897B2 (en) 2007-08-16 2013-09-10 Carnegie Mellon University Inflammation-regulating compositions and methods
US8221783B2 (en) 2007-09-10 2012-07-17 Boston Scientific Scimed, Inc. Medical devices with triggerable bioadhesive material
US20110104052A1 (en) 2007-12-03 2011-05-05 The Johns Hopkins University Methods of synthesis and use of chemospheres
EP2254610A4 (en) 2008-02-22 2013-07-31 Dermal Technologies Llc COMPOSITIONS FOR TISSUE REINFORCEMENT
US20100008989A1 (en) 2008-06-12 2010-01-14 Ishay Attar Process for manufacture of gelatin solutions and products thereof
EP2487206A3 (en) 2008-06-18 2012-11-28 Lifebond Ltd Cross-linkable gelatin-based compositions
EP2543394A1 (en) 2008-06-18 2013-01-09 Lifebond Ltd A method for enzymatic cross-linking of a protein
WO2009153748A2 (en) 2008-06-18 2009-12-23 Lifebond Ltd Methods and devices for use with sealants
WO2010027471A2 (en) 2008-09-04 2010-03-11 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair

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