JP2008507564A5

JP2008507564A5 -

Download PDF

Info

Publication number: JP2008507564A5
Authority: JP; Japan
Prior art keywords: trifluoromethyl; oxo; benzyl; dihydro; phenyl
Prior art date: 2005-07-24
Legal status : Granted

Application number

JP2007522845A

Other languages

English (en)

Japanese (ja)

Other versions

JP2008507564A (ja

JP5017607B2 (ja

Filing date

2005-07-24

Publication date

2008-09-11

2004-07-24 Priority claimed from US10/899,458 external-priority patent/US7482366B2/en

2005-07-24 Application filed filed Critical

2008-03-13 Publication of JP2008507564A publication Critical patent/JP2008507564A/ja

2008-09-11 Publication of JP2008507564A5 publication Critical patent/JP2008507564A5/ja

2012-09-05 Application granted granted Critical

2012-09-05 Publication of JP5017607B2 publication Critical patent/JP5017607B2/ja

2025-07-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

125000000217 alkyl group Chemical group 0.000 claims 178
229910052739 hydrogen Inorganic materials 0.000 claims 165
239000001257 hydrogen Substances 0.000 claims 165
150000001875 compounds Chemical class 0.000 claims 157
150000002431 hydrogen Chemical class 0.000 claims 127
125000001188 haloalkyl group Chemical group 0.000 claims 111
125000003710 aryl alkyl group Chemical group 0.000 claims 101
-1 chloro, bromo, fluoro, methyl Chemical group 0.000 claims 98
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 74
125000004446 heteroarylalkyl group Chemical group 0.000 claims 67
125000004093 cyano group Chemical group *C#N 0.000 claims 64
125000002947 alkylene group Chemical group 0.000 claims 62
125000005843 halogen group Chemical group 0.000 claims 57
125000001072 heteroaryl group Chemical group 0.000 claims 57
125000000623 heterocyclic group Chemical group 0.000 claims 57
125000001424 substituent group Chemical group 0.000 claims 57
125000004415 heterocyclylalkyl group Chemical group 0.000 claims 56
125000003118 aryl group Chemical group 0.000 claims 44
125000002768 hydroxyalkyl group Chemical group 0.000 claims 40
125000003107 substituted aryl group Chemical group 0.000 claims 39
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 38
125000003342 alkenyl group Chemical group 0.000 claims 38
125000004450 alkenylene group Chemical group 0.000 claims 38
239000000203 mixture Substances 0.000 claims 33
125000000262 haloalkenyl group Chemical group 0.000 claims 32
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 30
125000005346 substituted cycloalkyl group Chemical group 0.000 claims 30
125000006507 2,4-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(F)C(=C1[H])C([H])([H])* 0.000 claims 27
125000000753 cycloalkyl group Chemical group 0.000 claims 27
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 25
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 21
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 19
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 18
GMWICSNDPMNEJX-UHFFFAOYSA-N 1-methyl-2h-pyridine-3-carbonitrile Chemical compound CN1CC(C#N)=CC=C1 GMWICSNDPMNEJX-UHFFFAOYSA-N 0.000 claims 16
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 14
125000005020 hydroxyalkenyl group Chemical group 0.000 claims 14
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 13
208000035475 disorder Diseases 0.000 claims 11
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 10
108020005497 Nuclear hormone receptor Proteins 0.000 claims 9
125000004419 alkynylene group Chemical group 0.000 claims 9
QQXQAEWRSVZPJM-UHFFFAOYSA-N ethyl 1h-indole-2-carboxylate Chemical compound C1=CC=C2NC(C(=O)OCC)=CC2=C1 QQXQAEWRSVZPJM-UHFFFAOYSA-N 0.000 claims 9
102000006255 nuclear receptors Human genes 0.000 claims 9
108020004017 nuclear receptors Proteins 0.000 claims 9
125000001041 indolyl group Chemical group 0.000 claims 8
125000001309 chloro group Chemical group Cl* 0.000 claims 7
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 7
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 7
125000004076 pyridyl group Chemical group 0.000 claims 7
125000006183 2,4-dimethyl benzyl group Chemical group [H]C1=C(C([H])=C(C(=C1[H])C([H])([H])*)C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
201000010099 disease Diseases 0.000 claims 6
102000004311 liver X receptors Human genes 0.000 claims 6
108090000865 liver X receptors Proteins 0.000 claims 6
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
229910052717 sulfur Inorganic materials 0.000 claims 5
208000002874 Acne Vulgaris Diseases 0.000 claims 4
229910019142 PO4 Inorganic materials 0.000 claims 4
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
206010000496 acne Diseases 0.000 claims 4
150000001408 amides Chemical class 0.000 claims 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
206010012601 diabetes mellitus Diseases 0.000 claims 4
229910052760 oxygen Inorganic materials 0.000 claims 4
239000001301 oxygen Substances 0.000 claims 4
239000010452 phosphate Substances 0.000 claims 4
239000000651 prodrug Substances 0.000 claims 4
229940002612 prodrug Drugs 0.000 claims 4
150000003839 salts Chemical class 0.000 claims 4
239000012453 solvate Substances 0.000 claims 4
239000011593 sulfur Chemical group 0.000 claims 4
208000024891 symptom Diseases 0.000 claims 4
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 3
239000005977 Ethylene Substances 0.000 claims 3
235000012000 cholesterol Nutrition 0.000 claims 3
230000000694 effects Effects 0.000 claims 3
125000002883 imidazolyl group Chemical group 0.000 claims 3
125000004193 piperazinyl group Chemical group 0.000 claims 3
125000003386 piperidinyl group Chemical group 0.000 claims 3
125000003226 pyrazolyl group Chemical group 0.000 claims 3
125000000714 pyrimidinyl group Chemical group 0.000 claims 3
125000005017 substituted alkenyl group Chemical group 0.000 claims 3
125000000547 substituted alkyl group Chemical group 0.000 claims 3
JDPOGLZSFHUEPX-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JDPOGLZSFHUEPX-UHFFFAOYSA-N 0.000 claims 2
KQBYEGRTICKOBG-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n,n-dimethylbenzenecarbothioamide Chemical compound CN(C)C(=S)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 KQBYEGRTICKOBG-UHFFFAOYSA-N 0.000 claims 2
HNPYUGBMTRBYQR-UHFFFAOYSA-N 6-[4-(3-cyano-4-ethoxyphenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C#N)C(OCC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HNPYUGBMTRBYQR-UHFFFAOYSA-N 0.000 claims 2
108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims 2
102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims 2
208000024827 Alzheimer disease Diseases 0.000 claims 2
201000001320 Atherosclerosis Diseases 0.000 claims 2
102100038495 Bile acid receptor Human genes 0.000 claims 2
208000024172 Cardiovascular disease Diseases 0.000 claims 2
208000032928 Dyslipidaemia Diseases 0.000 claims 2
101000603876 Homo sapiens Bile acid receptor Proteins 0.000 claims 2
208000035150 Hypercholesterolemia Diseases 0.000 claims 2
208000031226 Hyperlipidaemia Diseases 0.000 claims 2
206010020961 Hypocholesterolaemia Diseases 0.000 claims 2
206010061218 Inflammation Diseases 0.000 claims 2
208000017170 Lipid metabolism disease Diseases 0.000 claims 2
206010049287 Lipodystrophy acquired Diseases 0.000 claims 2
206010028980 Neoplasm Diseases 0.000 claims 2
208000008589 Obesity Diseases 0.000 claims 2
208000018737 Parkinson disease Diseases 0.000 claims 2
230000037365 barrier function of the epidermis Effects 0.000 claims 2
125000000928 benzodioxinyl group Chemical group O1C(=COC2=C1C=CC=C2)* 0.000 claims 2
201000011510 cancer Diseases 0.000 claims 2
GTCAXTIRRLKXRU-UHFFFAOYSA-N carbamic acid methyl ester Natural products COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 claims 2
229910052799 carbon Inorganic materials 0.000 claims 2
201000001883 cholelithiasis Diseases 0.000 claims 2
230000004069 differentiation Effects 0.000 claims 2
125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
208000001130 gallstones Diseases 0.000 claims 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
201000001421 hyperglycemia Diseases 0.000 claims 2
208000020346 hyperlipoproteinemia Diseases 0.000 claims 2
208000006575 hypertriglyceridemia Diseases 0.000 claims 2
208000026278 immune system disease Diseases 0.000 claims 2
230000004054 inflammatory process Effects 0.000 claims 2
150000002632 lipids Chemical class 0.000 claims 2
208000006132 lipodystrophy Diseases 0.000 claims 2
125000002757 morpholinyl group Chemical group 0.000 claims 2
125000001624 naphthyl group Chemical group 0.000 claims 2
235000020824 obesity Nutrition 0.000 claims 2
208000017520 skin disease Diseases 0.000 claims 2
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
125000000335 thiazolyl group Chemical group 0.000 claims 2
125000001544 thienyl group Chemical group 0.000 claims 2
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
AEIUSTKFQMELDG-UHFFFAOYSA-N 1-(trifluoromethyl)-2h-pyridine-3-carbonitrile Chemical compound FC(F)(F)N1CC(C#N)=CC=C1 AEIUSTKFQMELDG-UHFFFAOYSA-N 0.000 claims 1
XMNBJJHCIIOANQ-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-2-oxo-4-(1,1,2,2,2-pentafluoroethyl)-6-(4-phenoxyphenyl)pyridine-3-carbonitrile Chemical compound C=1C=C(Cl)C=C(Cl)C=1CN1C(=O)C(C#N)=C(C(F)(F)C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XMNBJJHCIIOANQ-UHFFFAOYSA-N 0.000 claims 1
VISJHPGFSSQRKK-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[5-(2,4,5-trimethylphenyl)thiophen-2-yl]pyridine-3-carbonitrile Chemical compound C1=C(C)C(C)=CC(C)=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)S1 VISJHPGFSSQRKK-UHFFFAOYSA-N 0.000 claims 1
AQTWZLCZJUKHGF-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-2-oxo-6-(4-phenoxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C=1C=C(Cl)C=C(Cl)C=1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC=C1 AQTWZLCZJUKHGF-UHFFFAOYSA-N 0.000 claims 1
JYXIUVAKJSKBOS-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-2-oxo-6-(4-phenylmethoxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C=1C=C(Cl)C=C(Cl)C=1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OCC1=CC=CC=C1 JYXIUVAKJSKBOS-UHFFFAOYSA-N 0.000 claims 1
UMRBANYZUOQKEC-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-2-oxo-6-(4-pyrazin-2-yloxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C=1C=C(Cl)C=C(Cl)C=1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CN=CC=N1 UMRBANYZUOQKEC-UHFFFAOYSA-N 0.000 claims 1
PXOVGKVCSUBPPD-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[4-(1-methylindol-5-yl)oxyphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C=1C=C2N(C)C=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(Cl)C=C1Cl PXOVGKVCSUBPPD-UHFFFAOYSA-N 0.000 claims 1
MYFLTMHVQPXRCR-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[4-(1h-indol-5-yloxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound O=C1C(C#N)=C(C(F)(F)F)C=C(C=2C=CC(OC=3C=C4C=CNC4=CC=3)=CC=2)N1CC1=CC=C(Cl)C=C1Cl MYFLTMHVQPXRCR-UHFFFAOYSA-N 0.000 claims 1
HBMLXVMTBKNFJG-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(2-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)S1 HBMLXVMTBKNFJG-UHFFFAOYSA-N 0.000 claims 1
SSBSFYUVAHVNIM-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(3,4-dimethoxyphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)S1 SSBSFYUVAHVNIM-UHFFFAOYSA-N 0.000 claims 1
SLMWUQHUMGAYID-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(3,5-dichlorophenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C=1C=C(Cl)C=C(Cl)C=1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(S1)=CC=C1C1=CC(Cl)=CC(Cl)=C1 SLMWUQHUMGAYID-UHFFFAOYSA-N 0.000 claims 1
BRQMMKHOEHHJPS-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(3-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)=C1 BRQMMKHOEHHJPS-UHFFFAOYSA-N 0.000 claims 1
UOVBCXVHZIYVLG-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)=C1 UOVBCXVHZIYVLG-UHFFFAOYSA-N 0.000 claims 1
DDSNQFBSLLQMCB-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(4-methoxy-2-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)S1 DDSNQFBSLLQMCB-UHFFFAOYSA-N 0.000 claims 1
ZKMMUAIRMCNGHZ-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(4-methoxy-3-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)S1 ZKMMUAIRMCNGHZ-UHFFFAOYSA-N 0.000 claims 1
GRJPNPJWODIJDH-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(4-methylnaphthalen-1-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C12=CC=CC=C2C(C)=CC=C1C(S1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(Cl)C=C1Cl GRJPNPJWODIJDH-UHFFFAOYSA-N 0.000 claims 1
MJBRYOQLRBZBQN-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)S1 MJBRYOQLRBZBQN-UHFFFAOYSA-N 0.000 claims 1
OZAUDVUSTMKVDI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[1-[3-(trifluoromethyl)pyridin-2-yl]pyrazol-4-yl]pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(C=2C(=CC=CN=2)C(F)(F)F)N=C1 OZAUDVUSTMKVDI-UHFFFAOYSA-N 0.000 claims 1
JACOUOXDJKAWND-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[1-[5-(trifluoromethyl)pyridin-2-yl]pyrazol-4-yl]pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(C=2N=CC(=CC=2)C(F)(F)F)N=C1 JACOUOXDJKAWND-UHFFFAOYSA-N 0.000 claims 1
NOGMCFJLAKVLEX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[1-[6-(trifluoromethyl)pyridin-2-yl]pyrazol-4-yl]pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(C=2N=C(C=CC=2)C(F)(F)F)N=C1 NOGMCFJLAKVLEX-UHFFFAOYSA-N 0.000 claims 1
USPBKDHYISTRHQ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[4-[3-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC=CC=C1C(F)(F)F USPBKDHYISTRHQ-UHFFFAOYSA-N 0.000 claims 1
IZNGCJOFDHAFIR-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(C(F)(F)F)C=N1 IZNGCJOFDHAFIR-UHFFFAOYSA-N 0.000 claims 1
XNOGXEBAEVVXHT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[4-[6-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(C(F)(F)F)=N1 XNOGXEBAEVVXHT-UHFFFAOYSA-N 0.000 claims 1
BKOKTPYDAMRXAF-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[5-[3-(trifluoromethyl)phenyl]thiophen-2-yl]pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=CC=2)C(F)(F)F)S1 BKOKTPYDAMRXAF-UHFFFAOYSA-N 0.000 claims 1
SJUXRQWERQTJFD-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(1-phenylpyrazol-4-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(C=2C=CC=CC=2)N=C1 SJUXRQWERQTJFD-UHFFFAOYSA-N 0.000 claims 1
DRMFTAOHILZGJA-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(3-piperidin-1-ylphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(N2CCCCC2)=C1 DRMFTAOHILZGJA-UHFFFAOYSA-N 0.000 claims 1
LGQDCHNZNRYZDU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(3-pyridin-3-ylphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=NC=CC=2)=C1 LGQDCHNZNRYZDU-UHFFFAOYSA-N 0.000 claims 1
BBDUTILJEFJJLG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(3-pyridin-4-ylphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=CN=CC=2)=C1 BBDUTILJEFJJLG-UHFFFAOYSA-N 0.000 claims 1
SWBBNSPWRVCYAE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(4-phenoxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC=C1 SWBBNSPWRVCYAE-UHFFFAOYSA-N 0.000 claims 1
DXCRXGHIVBYYRT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(4-piperidin-1-ylphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(N2CCCCC2)C=C1 DXCRXGHIVBYYRT-UHFFFAOYSA-N 0.000 claims 1
MWHITVFFQSUMNG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(4-pyrazin-2-yloxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CN=CC=N1 MWHITVFFQSUMNG-UHFFFAOYSA-N 0.000 claims 1
CUAZFZWVYQIVTE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(4-pyridin-3-ylthiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=NC=CC=2)=CS1 CUAZFZWVYQIVTE-UHFFFAOYSA-N 0.000 claims 1
QCHPIMYBJYQZSO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(4-pyridin-4-ylfuran-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=CN=CC=2)=CO1 QCHPIMYBJYQZSO-UHFFFAOYSA-N 0.000 claims 1
APMDVODRGWDQEP-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(4-pyridin-4-ylthiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=CN=CC=2)=CS1 APMDVODRGWDQEP-UHFFFAOYSA-N 0.000 claims 1
KFNJUZBHFMEBFL-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(4-pyrimidin-2-yloxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC=CC=N1 KFNJUZBHFMEBFL-UHFFFAOYSA-N 0.000 claims 1
CNECVMBFFHFYOI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(5-pyridin-2-ylthiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2N=CC=CC=2)S1 CNECVMBFFHFYOI-UHFFFAOYSA-N 0.000 claims 1
QXRWBQOUVGKXJV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(5-pyridin-3-ylthiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=NC=CC=2)S1 QXRWBQOUVGKXJV-UHFFFAOYSA-N 0.000 claims 1
KEXYWZODQNAXPT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(5-pyridin-4-ylthiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=CN=CC=2)S1 KEXYWZODQNAXPT-UHFFFAOYSA-N 0.000 claims 1
SOWURGAGTJAFGY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-(5-pyrimidin-5-ylthiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=NC=NC=2)S1 SOWURGAGTJAFGY-UHFFFAOYSA-N 0.000 claims 1
ALIBVKZDSDEKRE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=C(C(F)(F)F)N(C=2C=CC=CC=2)N=C1 ALIBVKZDSDEKRE-UHFFFAOYSA-N 0.000 claims 1
UFMWJYWBPVIPCP-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-(1,3-thiazol-2-yl)phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2SC=CN=2)=C1 UFMWJYWBPVIPCP-UHFFFAOYSA-N 0.000 claims 1
AFNZKUSXTVFXET-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-(2-phenylethynyl)phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C#CC=2C=CC=CC=2)=C1 AFNZKUSXTVFXET-UHFFFAOYSA-N 0.000 claims 1
UWVLFNIBLWUTSS-MDZDMXLPSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-[(e)-2-phenylethenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(\C=C\C=2C=CC=CC=2)=C1 UWVLFNIBLWUTSS-MDZDMXLPSA-N 0.000 claims 1
XQBZEERBDUFYCU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-[3-(pyrrolidine-1-carbonyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(C=CC=2)C(=O)N2CCCC2)=C1 XQBZEERBDUFYCU-UHFFFAOYSA-N 0.000 claims 1
YJEYNUWRXAMZSX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-[3-propan-2-ylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C(C)C)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YJEYNUWRXAMZSX-UHFFFAOYSA-N 0.000 claims 1
PVGXZBQUBGZNDU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-[3-propylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCC)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 PVGXZBQUBGZNDU-UHFFFAOYSA-N 0.000 claims 1
BPCMBXGDRKSXII-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-[3-propylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCC)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BPCMBXGDRKSXII-UHFFFAOYSA-N 0.000 claims 1
RROLOQVXYGXVRJ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[3-[4-(piperidine-1-carbonyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=CC(=CC=2)C(=O)N2CCCCC2)=C1 RROLOQVXYGXVRJ-UHFFFAOYSA-N 0.000 claims 1
YTUQCQVZNOSEGL-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-(2-phenylethynyl)phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C#CC=2C=CC=CC=2)C=C1 YTUQCQVZNOSEGL-UHFFFAOYSA-N 0.000 claims 1
NJIBDACNQLXACU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-(2-phenylethynyl)thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C#CC=2C=CC=CC=2)=CS1 NJIBDACNQLXACU-UHFFFAOYSA-N 0.000 claims 1
NOLCAUHPRZPFFG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-(6-piperazin-1-ylpyridin-3-yl)furan-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=NC(=CC=2)N2CCNCC2)=CO1 NOLCAUHPRZPFFG-UHFFFAOYSA-N 0.000 claims 1
CBSFNVOZCFRRCA-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-(6-piperazin-1-ylpyridin-3-yl)thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=NC(=CC=2)N2CCNCC2)=CS1 CBSFNVOZCFRRCA-UHFFFAOYSA-N 0.000 claims 1
ZDOYQQBBZLZBOH-VOTSOKGWSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[(e)-2-phenylethenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1\C=C\C1=CC=CC=C1 ZDOYQQBBZLZBOH-VOTSOKGWSA-N 0.000 claims 1
CNRCETNARDFBKY-VOTSOKGWSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[(e)-2-phenylethenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(\C=C\C=2C=CC=CC=2)=CS1 CNRCETNARDFBKY-VOTSOKGWSA-N 0.000 claims 1
ZKVFUFYWMGPLDD-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]furan-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(OC(C)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ZKVFUFYWMGPLDD-UHFFFAOYSA-N 0.000 claims 1
JRLGETPPDVXZDE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(OC(C)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JRLGETPPDVXZDE-UHFFFAOYSA-N 0.000 claims 1
BGTSRBZCXQLBBC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propan-2-ylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)C(C)C)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BGTSRBZCXQLBBC-UHFFFAOYSA-N 0.000 claims 1
DUUBWXAKYOAJCK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propan-2-ylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)C(C)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 DUUBWXAKYOAJCK-UHFFFAOYSA-N 0.000 claims 1
IHHBXFZGZNCBMA-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propan-2-ylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C(C)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IHHBXFZGZNCBMA-UHFFFAOYSA-N 0.000 claims 1
WZCICYBJTKAGQP-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propan-2-ylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C(C)C)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WZCICYBJTKAGQP-UHFFFAOYSA-N 0.000 claims 1
JMJFVGXFOMHBDI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCC)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JMJFVGXFOMHBDI-UHFFFAOYSA-N 0.000 claims 1
MXVPAUIOEYGQBI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MXVPAUIOEYGQBI-UHFFFAOYSA-N 0.000 claims 1
XQGTWYBZHGXHHC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XQGTWYBZHGXHHC-UHFFFAOYSA-N 0.000 claims 1
XOOWHENLFUOAOY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCC)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XOOWHENLFUOAOY-UHFFFAOYSA-N 0.000 claims 1
FQWFOXFTDHWJTK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[3-propylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FQWFOXFTDHWJTK-UHFFFAOYSA-N 0.000 claims 1
HTYMVPFPTUZNFE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[4-[6-propan-2-yloxy-5-(trifluoromethyl)pyridin-3-yl]furan-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OC(C)C)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HTYMVPFPTUZNFE-UHFFFAOYSA-N 0.000 claims 1
RGLDGADCWSCDRU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-(2-phenylethyl)thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(S1)=CC=C1CCC1=CC=CC=C1 RGLDGADCWSCDRU-UHFFFAOYSA-N 0.000 claims 1
WOIHMEFEHIOODR-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-(2-phenylethynyl)thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C#CC=2C=CC=CC=2)S1 WOIHMEFEHIOODR-UHFFFAOYSA-N 0.000 claims 1
VWQQHLQQNKAAHT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-(6-piperazin-1-ylpyridin-3-yl)thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=NC(=CC=2)N2CCNCC2)S1 VWQQHLQQNKAAHT-UHFFFAOYSA-N 0.000 claims 1
KCKHALFCDHLXOC-RMKNXTFCSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-[(e)-2-phenylethenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(S1)=CC=C1\C=C\C1=CC=CC=C1 KCKHALFCDHLXOC-RMKNXTFCSA-N 0.000 claims 1
KOXAKSUVQQWSRB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-[3-propan-2-yloxy-5-(trifluoromethyl)phenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(OC(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KOXAKSUVQQWSRB-UHFFFAOYSA-N 0.000 claims 1
JAQKBFPRDBCOCY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-[3-propan-2-ylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C(C)C)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JAQKBFPRDBCOCY-UHFFFAOYSA-N 0.000 claims 1
ZVLCRDPHUNAUAO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-[3-propylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ZVLCRDPHUNAUAO-UHFFFAOYSA-N 0.000 claims 1
XYJOSUMHJRGAAB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-[3-propylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCC)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XYJOSUMHJRGAAB-UHFFFAOYSA-N 0.000 claims 1
IELNFMXEOSJBFZ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-[3-propylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IELNFMXEOSJBFZ-UHFFFAOYSA-N 0.000 claims 1
AREXPDLPARKKEK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-2-oxo-6-[5-[6-propan-2-yloxy-5-(trifluoromethyl)pyridin-3-yl]thiophen-2-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OC(C)C)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 AREXPDLPARKKEK-UHFFFAOYSA-N 0.000 claims 1
NOYRXCOEOQQLBG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-3-[(dimethylamino)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-4-(trifluoromethyl)pyridin-2-one Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(CN(C)C)=C(C(F)(F)F)C=C1C(S1)=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 NOYRXCOEOQQLBG-UHFFFAOYSA-N 0.000 claims 1
XIVVKLGDUOVAED-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-4-(1,1-difluoropropyl)-6-[4-(3-ethylsulfonyl-5-propan-2-ylphenyl)furan-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CC)C=C1C(OC=1)=CC=1C1=CC(C(C)C)=CC(S(=O)(=O)CC)=C1 XIVVKLGDUOVAED-UHFFFAOYSA-N 0.000 claims 1
ZZOGXXFIFPFOLW-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-4-(1,1-difluoropropyl)-6-[4-(5-methyl-6-methylsulfonylpyridin-3-yl)furan-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CC)C=C1C(OC=1)=CC=1C1=CN=C(S(C)(=O)=O)C(C)=C1 ZZOGXXFIFPFOLW-UHFFFAOYSA-N 0.000 claims 1
OTKHMLBPNHDHDF-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=NN(C=2C=CC=CC=2)C(C)=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(F)C=C1F OTKHMLBPNHDHDF-UHFFFAOYSA-N 0.000 claims 1
HSXYRJYPCOBGGB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-(5-methyl-1-phenylpyrazol-4-yl)-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=NN1C1=CC=CC=C1 HSXYRJYPCOBGGB-UHFFFAOYSA-N 0.000 claims 1
TXWDDQOTTKVNNB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[1-(3,4-dimethoxyphenyl)pyrazol-4-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1N1N=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 TXWDDQOTTKVNNB-UHFFFAOYSA-N 0.000 claims 1
HGAYYOMRSGIOCI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[1-(4-methylsulfonylphenyl)pyrazol-4-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1N1N=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HGAYYOMRSGIOCI-UHFFFAOYSA-N 0.000 claims 1
PSZCSIJLAJJMQB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(OC)=CC=C1CN1N=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 PSZCSIJLAJJMQB-UHFFFAOYSA-N 0.000 claims 1
GEQYACHEQNDDLR-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-(1h-indol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3C=CNC3=CC=2)=C1 GEQYACHEQNDDLR-UHFFFAOYSA-N 0.000 claims 1
DMORGUAUXBVXAU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-(3-ethyl-5-methylsulfonylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(CC)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 DMORGUAUXBVXAU-UHFFFAOYSA-N 0.000 claims 1
PCFYBVUYLSSQPZ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-(3-ethylsulfonyl-5-propan-2-ylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC(C(C)C)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 PCFYBVUYLSSQPZ-UHFFFAOYSA-N 0.000 claims 1
SUVRPJXXJDGAND-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-(3-methylsulfonyl-5-propan-2-ylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)C)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 SUVRPJXXJDGAND-UHFFFAOYSA-N 0.000 claims 1
KLOOMQJCCIEGRU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-(4-ethoxy-3-methylsulfonylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(S(C)(=O)=O)C(OCC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KLOOMQJCCIEGRU-UHFFFAOYSA-N 0.000 claims 1
CVYDGGHQTMBLOZ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-(4-ethoxy-3-nitrophenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C([N+]([O-])=O)C(OCC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CVYDGGHQTMBLOZ-UHFFFAOYSA-N 0.000 claims 1
IQRWXBMMIGNYQM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-(4-methylsulfonylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IQRWXBMMIGNYQM-UHFFFAOYSA-N 0.000 claims 1
RNDYNTIVVIWFKN-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 RNDYNTIVVIWFKN-UHFFFAOYSA-N 0.000 claims 1
USCPXJIXMUJPFN-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-[3-methylsulfanyl-5-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(SC)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 USCPXJIXMUJPFN-UHFFFAOYSA-N 0.000 claims 1
CTZFMQUECPSMCX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-[4-ethylsulfanyl-3-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(SCC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CTZFMQUECPSMCX-UHFFFAOYSA-N 0.000 claims 1
WHRZPRAYBBYNNX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-[4-ethylsulfonyl-3-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)CC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WHRZPRAYBBYNNX-UHFFFAOYSA-N 0.000 claims 1
YBULYPKAGWEZJI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-[4-methylsulfanyl-3-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(SC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YBULYPKAGWEZJI-UHFFFAOYSA-N 0.000 claims 1
QXOPKDYLFPYJMV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[3-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QXOPKDYLFPYJMV-UHFFFAOYSA-N 0.000 claims 1
CUNYPUHYGCXKHY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(1h-indol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3C=CNC3=CC=2)C=C1 CUNYPUHYGCXKHY-UHFFFAOYSA-N 0.000 claims 1
MOFBEELIBMZPCN-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(1h-indol-5-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C3C=CNC3=CC=2)=CS1 MOFBEELIBMZPCN-UHFFFAOYSA-N 0.000 claims 1
BFNKSVXPYFTKNX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(1h-indol-5-yloxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC=C2)C2=C1 BFNKSVXPYFTKNX-UHFFFAOYSA-N 0.000 claims 1
TVCDYWMGUYCTIX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(1h-indol-6-yloxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(C=CN2)C2=C1 TVCDYWMGUYCTIX-UHFFFAOYSA-N 0.000 claims 1
PJHXZINXXHCPGV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(2,3-dihydro-1-benzofuran-5-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C3CCOC3=CC=2)=CS1 PJHXZINXXHCPGV-UHFFFAOYSA-N 0.000 claims 1
MCNIRNLAPFJEIE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3,4-dimethoxyphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 MCNIRNLAPFJEIE-UHFFFAOYSA-N 0.000 claims 1
MGFGCECHERQIOO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3,4-dimethoxyphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MGFGCECHERQIOO-UHFFFAOYSA-N 0.000 claims 1
RHVRJQFVLZFOGB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-ethoxy-5-ethylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCOC1=CC(CC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 RHVRJQFVLZFOGB-UHFFFAOYSA-N 0.000 claims 1
UXCNZJOENISPNO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-ethoxy-5-ethylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCOC1=CC(CC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UXCNZJOENISPNO-UHFFFAOYSA-N 0.000 claims 1
LVPHRQMJVRFPPK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-ethyl-5-ethylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC(CC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 LVPHRQMJVRFPPK-UHFFFAOYSA-N 0.000 claims 1
HVKHUQCMNMZUKD-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-ethyl-5-methylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(CC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HVKHUQCMNMZUKD-UHFFFAOYSA-N 0.000 claims 1
IHZBYPJDGPPEGB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-ethyl-5-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(CC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IHZBYPJDGPPEGB-UHFFFAOYSA-N 0.000 claims 1
KNUOUGLGNXOOLF-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-ethyl-5-propan-2-yloxyphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCC1=CC(OC(C)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KNUOUGLGNXOOLF-UHFFFAOYSA-N 0.000 claims 1
XHLKYMLSXAUJNM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-ethyl-5-propan-2-yloxyphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCC1=CC(OC(C)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XHLKYMLSXAUJNM-UHFFFAOYSA-N 0.000 claims 1
UMBQELZYKMPTTQ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-hydroxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound OC1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UMBQELZYKMPTTQ-UHFFFAOYSA-N 0.000 claims 1
NXHIDRVAXGLCRE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-methylsulfonyl-5-propan-2-ylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NXHIDRVAXGLCRE-UHFFFAOYSA-N 0.000 claims 1
NZRZJDDYSVXWSL-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(3-methylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NZRZJDDYSVXWSL-UHFFFAOYSA-N 0.000 claims 1
YTVORDFUBNWLHX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(4-ethoxy-3-nitrophenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C([N+]([O-])=O)C(OCC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YTVORDFUBNWLHX-UHFFFAOYSA-N 0.000 claims 1
LEYNVOAXEPLXBJ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(4-fluorophenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(F)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 LEYNVOAXEPLXBJ-UHFFFAOYSA-N 0.000 claims 1
HXTRSVNRWCRWJS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(4-hydroxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(O)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 HXTRSVNRWCRWJS-UHFFFAOYSA-N 0.000 claims 1
ZGSOPEANNYFQHH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(4-methylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ZGSOPEANNYFQHH-UHFFFAOYSA-N 0.000 claims 1
MOFVXLCAXLVRFP-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(4-methylsulfonylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 MOFVXLCAXLVRFP-UHFFFAOYSA-N 0.000 claims 1
PVXOQMTXBZBXCH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 PVXOQMTXBZBXCH-UHFFFAOYSA-N 0.000 claims 1
WCFPVJVPAPCSFO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(5-methyl-6-methylsulfanylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(SC)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WCFPVJVPAPCSFO-UHFFFAOYSA-N 0.000 claims 1
UNTXPCOKTJZCMU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(5-methyl-6-methylsulfanylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(SC)=NC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UNTXPCOKTJZCMU-UHFFFAOYSA-N 0.000 claims 1
MAAYMBKYVTZZCP-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(5-methyl-6-methylsulfonylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MAAYMBKYVTZZCP-UHFFFAOYSA-N 0.000 claims 1
GBWMWIAAKXUWGM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(5-methyl-6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GBWMWIAAKXUWGM-UHFFFAOYSA-N 0.000 claims 1
MWGQQQJBGFPTRY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethoxy-5-prop-1-en-2-ylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(C)=C)C(OCC)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MWGQQQJBGFPTRY-UHFFFAOYSA-N 0.000 claims 1
NDURZCOHRHZODW-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethoxy-5-prop-1-en-2-ylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(C)=C)C(OCC)=NC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NDURZCOHRHZODW-UHFFFAOYSA-N 0.000 claims 1
STINYFKAUMFMCP-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethoxy-5-propan-2-ylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(C)C)C(OCC)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 STINYFKAUMFMCP-UHFFFAOYSA-N 0.000 claims 1
XZFRITYOQXFYAB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethoxy-5-propan-2-ylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(C)C)C(OCC)=NC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XZFRITYOQXFYAB-UHFFFAOYSA-N 0.000 claims 1
BZOUCWVRZHOWCD-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethoxypyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(OCC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BZOUCWVRZHOWCD-UHFFFAOYSA-N 0.000 claims 1
IALYQCLODRELTE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethoxypyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(OCC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IALYQCLODRELTE-UHFFFAOYSA-N 0.000 claims 1
XVKZNSUBGNZLHV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethylsulfanyl-5-methylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(SCC)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XVKZNSUBGNZLHV-UHFFFAOYSA-N 0.000 claims 1
FNUHGURTYDMYMM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethylsulfonyl-5-methylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(S(=O)(=O)CC)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FNUHGURTYDMYMM-UHFFFAOYSA-N 0.000 claims 1
CFSHYGZBHIRBPC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-ethylsulfonyl-5-methylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(S(=O)(=O)CC)=NC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CFSHYGZBHIRBPC-UHFFFAOYSA-N 0.000 claims 1
BOESUZOJUQQCFZ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-methylsulfanylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(SC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BOESUZOJUQQCFZ-UHFFFAOYSA-N 0.000 claims 1
BMSMQLUCABDXFC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-methylsulfanylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(SC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BMSMQLUCABDXFC-UHFFFAOYSA-N 0.000 claims 1
JESKIKIDZIFLJD-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-methylsulfonyl-5-propan-2-ylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C(C)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JESKIKIDZIFLJD-UHFFFAOYSA-N 0.000 claims 1
CKJVCFYIWPLGAC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-methylsulfonylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(S(=O)(=O)C)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CKJVCFYIWPLGAC-UHFFFAOYSA-N 0.000 claims 1
PLCOHAYQSLZRPX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(S(=O)(=O)C)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 PLCOHAYQSLZRPX-UHFFFAOYSA-N 0.000 claims 1
DAPVHLWTGGGBBU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-(6-morpholin-4-ylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=NC(=CC=2)N2CCOCC2)=CS1 DAPVHLWTGGGBBU-UHFFFAOYSA-N 0.000 claims 1
YKPZUIKEUXACGC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethoxy-4-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YKPZUIKEUXACGC-UHFFFAOYSA-N 0.000 claims 1
VWGBWGBIRNXJQG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethoxy-4-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VWGBWGBIRNXJQG-UHFFFAOYSA-N 0.000 claims 1
VQEHXQODJQQUGZ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethoxy-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(OCC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VQEHXQODJQQUGZ-UHFFFAOYSA-N 0.000 claims 1
CFGKBQLBOHEGOB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CC)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CFGKBQLBOHEGOB-UHFFFAOYSA-N 0.000 claims 1
CZMBPKQWOMIXOE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CZMBPKQWOMIXOE-UHFFFAOYSA-N 0.000 claims 1
JMFNZIMEZXQPND-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JMFNZIMEZXQPND-UHFFFAOYSA-N 0.000 claims 1
TUQGFXZCGNILNU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 TUQGFXZCGNILNU-UHFFFAOYSA-N 0.000 claims 1
BXXXBARAZSKGER-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BXXXBARAZSKGER-UHFFFAOYSA-N 0.000 claims 1
HMYJZZFGDSDSSH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-fluoro-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(C=C(F)C=2)C(F)(F)F)=CS1 HMYJZZFGDSDSSH-UHFFFAOYSA-N 0.000 claims 1
HCQWYOLIHPMNRS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-methoxy-4-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HCQWYOLIHPMNRS-UHFFFAOYSA-N 0.000 claims 1
CZWPESXJTYRQDU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-methylsulfanyl-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(SC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CZWPESXJTYRQDU-UHFFFAOYSA-N 0.000 claims 1
ZPAYLTNHPFEHSG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-methylsulfanyl-5-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(SC)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ZPAYLTNHPFEHSG-UHFFFAOYSA-N 0.000 claims 1
NQDMFXPIMXKXHH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-methylsulfanyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(SC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NQDMFXPIMXKXHH-UHFFFAOYSA-N 0.000 claims 1
IDISDMHKRLVHEW-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-methylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IDISDMHKRLVHEW-UHFFFAOYSA-N 0.000 claims 1
BMIXPKAMOGULPQ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-methylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BMIXPKAMOGULPQ-UHFFFAOYSA-N 0.000 claims 1
OQSYTANJHOOCFB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[3-methylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OQSYTANJHOOCFB-UHFFFAOYSA-N 0.000 claims 1
AUOWVJYYWFLTFM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-ethoxy-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OCC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 AUOWVJYYWFLTFM-UHFFFAOYSA-N 0.000 claims 1
FMQAFVTYXDXYAJ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-ethoxy-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OCC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FMQAFVTYXDXYAJ-UHFFFAOYSA-N 0.000 claims 1
LAUSBQAEXVYRDY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(C(F)=CC=2)C(F)(F)F)=CO1 LAUSBQAEXVYRDY-UHFFFAOYSA-N 0.000 claims 1
JZYNDZJUFJVBMN-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JZYNDZJUFJVBMN-UHFFFAOYSA-N 0.000 claims 1
NJXCLBIGOZQLTN-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methoxy-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NJXCLBIGOZQLTN-UHFFFAOYSA-N 0.000 claims 1
GUPWPHHWXBRFMX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methylsulfanyl-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(SC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GUPWPHHWXBRFMX-UHFFFAOYSA-N 0.000 claims 1
DOZFXZOGGFBFFA-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methylsulfanyl-3-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(SC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 DOZFXZOGGFBFFA-UHFFFAOYSA-N 0.000 claims 1
GDQPSTGPIKASAB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methylsulfanyl-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(SC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GDQPSTGPIKASAB-UHFFFAOYSA-N 0.000 claims 1
BEVOOSIIBHEBSI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BEVOOSIIBHEBSI-UHFFFAOYSA-N 0.000 claims 1
YVSYBZLJCHISOS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 YVSYBZLJCHISOS-UHFFFAOYSA-N 0.000 claims 1
DNBGNARIHSVTHS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 DNBGNARIHSVTHS-UHFFFAOYSA-N 0.000 claims 1
GSXTVAXFEJJXDJ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[4-[6-ethoxy-5-(trifluoromethyl)pyridin-3-yl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OCC)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GSXTVAXFEJJXDJ-UHFFFAOYSA-N 0.000 claims 1
XWDLEYYHBIANIE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3OCCOC3=CC=2)O1 XWDLEYYHBIANIE-UHFFFAOYSA-N 0.000 claims 1
DJDWJBKDSMMXNK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3OCCOC3=CC=2)S1 DJDWJBKDSMMXNK-UHFFFAOYSA-N 0.000 claims 1
HEBQGDZYZNLPMK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(2,3-dihydro-1-benzofuran-5-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3CCOC3=CC=2)S1 HEBQGDZYZNLPMK-UHFFFAOYSA-N 0.000 claims 1
AWCKDOCWAQWUKO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(2,4-dimethoxypyrimidin-5-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound COC1=NC(OC)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 AWCKDOCWAQWUKO-UHFFFAOYSA-N 0.000 claims 1
FIYPCHNFNQIHQU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(2,4-dimethoxypyrimidin-5-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound COC1=NC(OC)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 FIYPCHNFNQIHQU-UHFFFAOYSA-N 0.000 claims 1
WKIUKYAFZMIEOX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(2-ethyl-6-ethylsulfonylpyridin-4-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=NC(CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WKIUKYAFZMIEOX-UHFFFAOYSA-N 0.000 claims 1
MJUKSQCONMZYOQ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(2-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 MJUKSQCONMZYOQ-UHFFFAOYSA-N 0.000 claims 1
XIOXAYJCXZHACV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3,4-dimethoxyphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 XIOXAYJCXZHACV-UHFFFAOYSA-N 0.000 claims 1
HIQXQBGMTRZNIZ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3,4-dimethoxyphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 HIQXQBGMTRZNIZ-UHFFFAOYSA-N 0.000 claims 1
RRJPWAPAKRCRIQ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethoxy-5-ethylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCOC1=CC(CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 RRJPWAPAKRCRIQ-UHFFFAOYSA-N 0.000 claims 1
UOYDHGBNKRDIEB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethyl-5-ethylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC(CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UOYDHGBNKRDIEB-UHFFFAOYSA-N 0.000 claims 1
TVYAUXOMFXNJQI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethyl-5-methylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(CC)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 TVYAUXOMFXNJQI-UHFFFAOYSA-N 0.000 claims 1
GXQUWYLXFSXFQG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethyl-5-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GXQUWYLXFSXFQG-UHFFFAOYSA-N 0.000 claims 1
OYYBYRIRVPEAHI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethyl-5-propan-2-yloxyphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCC1=CC(OC(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OYYBYRIRVPEAHI-UHFFFAOYSA-N 0.000 claims 1
JHNBHVGWDBSFQS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JHNBHVGWDBSFQS-UHFFFAOYSA-N 0.000 claims 1
GYJBASYPLGYRKK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GYJBASYPLGYRKK-UHFFFAOYSA-N 0.000 claims 1
OQHBGTXOOIXQHK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OQHBGTXOOIXQHK-UHFFFAOYSA-N 0.000 claims 1
QWDWGLWJSGKEIH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-formyl-4-methoxyphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C=O)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 QWDWGLWJSGKEIH-UHFFFAOYSA-N 0.000 claims 1
MWIPURQZXBLIMI-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MWIPURQZXBLIMI-UHFFFAOYSA-N 0.000 claims 1
OQPUNOTVHBALDS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-methylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OQPUNOTVHBALDS-UHFFFAOYSA-N 0.000 claims 1
XOJPYBFANHGJSA-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XOJPYBFANHGJSA-UHFFFAOYSA-N 0.000 claims 1
WPGIFTVVEKGIGJ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WPGIFTVVEKGIGJ-UHFFFAOYSA-N 0.000 claims 1
MUGIBSKMCWYHIY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-ethoxy-3-nitrophenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C([N+]([O-])=O)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 MUGIBSKMCWYHIY-UHFFFAOYSA-N 0.000 claims 1
VFNCZUZECZVNRR-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-ethylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)CC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 VFNCZUZECZVNRR-UHFFFAOYSA-N 0.000 claims 1
QPWYUIXOIHUOAM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-hydroxy-3,5-dimethylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=C(O)C(C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QPWYUIXOIHUOAM-UHFFFAOYSA-N 0.000 claims 1
YDOIFBPKNBSOIQ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-hydroxy-3-methoxyphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(O)C(OC)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YDOIFBPKNBSOIQ-UHFFFAOYSA-N 0.000 claims 1
BXJKEBGYIGAJPS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methoxy-3,5-dimethylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(OC)=C(C)C=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 BXJKEBGYIGAJPS-UHFFFAOYSA-N 0.000 claims 1
LMFIGHHEANGVLV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methoxy-3-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 LMFIGHHEANGVLV-UHFFFAOYSA-N 0.000 claims 1
XHHHBIZARLBBCT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methyl-3-methylsulfanylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(SC)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XHHHBIZARLBBCT-UHFFFAOYSA-N 0.000 claims 1
IVXZDCDJUIOIIS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methyl-3-methylsulfanylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(SC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IVXZDCDJUIOIIS-UHFFFAOYSA-N 0.000 claims 1
RSTPCEKGWHGIQC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfanylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(SC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 RSTPCEKGWHGIQC-UHFFFAOYSA-N 0.000 claims 1
MTUZHBRCZFOPQH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 MTUZHBRCZFOPQH-UHFFFAOYSA-N 0.000 claims 1
RTTIADRNBDHLNM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 RTTIADRNBDHLNM-UHFFFAOYSA-N 0.000 claims 1
PJFFIYDDIJIHTE-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(5-methyl-6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 PJFFIYDDIJIHTE-UHFFFAOYSA-N 0.000 claims 1
RHCLZGAKXLKEOB-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-ethoxy-2-methylsulfonylpyrimidin-4-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=NC(OCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=N1 RHCLZGAKXLKEOB-UHFFFAOYSA-N 0.000 claims 1
JRLNDUVAPHQFOT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-ethoxy-5-prop-1-en-2-ylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(C)=C)C(OCC)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 JRLNDUVAPHQFOT-UHFFFAOYSA-N 0.000 claims 1
BUSYUOPLQRCVAJ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-ethoxy-5-propan-2-ylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(C)C)C(OCC)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 BUSYUOPLQRCVAJ-UHFFFAOYSA-N 0.000 claims 1
COEWZNQVRGLGQG-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-ethoxypyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 COEWZNQVRGLGQG-UHFFFAOYSA-N 0.000 claims 1
FKIQZVYSPIHFEO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-ethylsulfanyl-5-methylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(SCC)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 FKIQZVYSPIHFEO-UHFFFAOYSA-N 0.000 claims 1
WZOGENUNRUGGAF-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-ethylsulfonyl-5-methylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C)C(S(=O)(=O)CC)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 WZOGENUNRUGGAF-UHFFFAOYSA-N 0.000 claims 1
XROXPSXOGVANBV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-methoxypyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 XROXPSXOGVANBV-UHFFFAOYSA-N 0.000 claims 1
IVVAMZLPDPQIFL-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-methoxypyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 IVVAMZLPDPQIFL-UHFFFAOYSA-N 0.000 claims 1
BUEFIIBQLMYWKH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-methylsulfanylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(SC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 BUEFIIBQLMYWKH-UHFFFAOYSA-N 0.000 claims 1
KKRVACAXCUQXFL-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-methylsulfonyl-5-propan-2-ylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KKRVACAXCUQXFL-UHFFFAOYSA-N 0.000 claims 1
AIXMTQUKNVXOKS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-methylsulfonylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 AIXMTQUKNVXOKS-UHFFFAOYSA-N 0.000 claims 1
GAZCZZLTLGENEV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 GAZCZZLTLGENEV-UHFFFAOYSA-N 0.000 claims 1
BESGBTUPUOHYFV-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-(6-morpholin-4-ylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=NC(=CC=2)N2CCOCC2)S1 BESGBTUPUOHYFV-UHFFFAOYSA-N 0.000 claims 1
WWSGDKQSVRZIQC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[2-fluoro-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C(=CC=C(C=2)C(F)(F)F)F)S1 WWSGDKQSVRZIQC-UHFFFAOYSA-N 0.000 claims 1
OATISKGBSRVMKM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[2-methylsulfonyl-6-(trifluoromethyl)pyridin-4-yl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=NC(S(=O)(=O)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OATISKGBSRVMKM-UHFFFAOYSA-N 0.000 claims 1
SGRCNKULUIAJHS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-(hydroxymethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound OCC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 SGRCNKULUIAJHS-UHFFFAOYSA-N 0.000 claims 1
WGGJIMRMZVPMRX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-ethoxy-4-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WGGJIMRMZVPMRX-UHFFFAOYSA-N 0.000 claims 1
QUOKFPDZIWCVBU-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-ethoxy-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(OCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QUOKFPDZIWCVBU-UHFFFAOYSA-N 0.000 claims 1
UAUADDYZMIBDBH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-ethylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UAUADDYZMIBDBH-UHFFFAOYSA-N 0.000 claims 1
IJELDZWTXRWDFM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IJELDZWTXRWDFM-UHFFFAOYSA-N 0.000 claims 1
RFMOFHWRNUAAKH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 RFMOFHWRNUAAKH-UHFFFAOYSA-N 0.000 claims 1
AYOVWTRVFGLXPT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-fluoro-4-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(F)C(=CC=2)C(F)(F)F)O1 AYOVWTRVFGLXPT-UHFFFAOYSA-N 0.000 claims 1
IBEBJUHBSMFSMH-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-fluoro-4-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(F)C(=CC=2)C(F)(F)F)S1 IBEBJUHBSMFSMH-UHFFFAOYSA-N 0.000 claims 1
JXBLGACEGFGEOM-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-fluoro-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(F)C=2)C(F)(F)F)O1 JXBLGACEGFGEOM-UHFFFAOYSA-N 0.000 claims 1
PCPOATFPAGKWMR-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-fluoro-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(F)C=2)C(F)(F)F)S1 PCPOATFPAGKWMR-UHFFFAOYSA-N 0.000 claims 1
CBTFSZGFTGTVJA-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-methylsulfanyl-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(SC)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CBTFSZGFTGTVJA-UHFFFAOYSA-N 0.000 claims 1
HQNLYIMYYAZANF-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-methylsulfanyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(SC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HQNLYIMYYAZANF-UHFFFAOYSA-N 0.000 claims 1
KJFWQXDLUQQLBO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-methylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KJFWQXDLUQQLBO-UHFFFAOYSA-N 0.000 claims 1
GFGPYXRLQUWWGL-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[3-methylsulfonyl-5-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GFGPYXRLQUWWGL-UHFFFAOYSA-N 0.000 claims 1
MTMZIDUHQZLOHY-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-(hydroxymethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(CO)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 MTMZIDUHQZLOHY-UHFFFAOYSA-N 0.000 claims 1
FXYNXBUAZRJLRO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-ethoxy-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 FXYNXBUAZRJLRO-UHFFFAOYSA-N 0.000 claims 1
QVIHRBNMQNPQPC-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C(F)=CC=2)C(F)(F)F)O1 QVIHRBNMQNPQPC-UHFFFAOYSA-N 0.000 claims 1
ZQWLYSOYELQJLX-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-methoxy-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 ZQWLYSOYELQJLX-UHFFFAOYSA-N 0.000 claims 1
MHWYOSYJDRXKRK-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-methoxy-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 MHWYOSYJDRXKRK-UHFFFAOYSA-N 0.000 claims 1
OWYQYECLEYUTJO-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-methylsulfanyl-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(SC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 OWYQYECLEYUTJO-UHFFFAOYSA-N 0.000 claims 1
VCYLAKQWDNQBAT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-methylsulfanyl-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(SC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 VCYLAKQWDNQBAT-UHFFFAOYSA-N 0.000 claims 1
JVLZHZDOJYBBSP-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-methylsulfinyl-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 JVLZHZDOJYBBSP-UHFFFAOYSA-N 0.000 claims 1
KFMAQHCQKZZTAT-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 KFMAQHCQKZZTAT-UHFFFAOYSA-N 0.000 claims 1
DXIVDFMMUOBMBZ-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 DXIVDFMMUOBMBZ-UHFFFAOYSA-N 0.000 claims 1
MLIQGTNYAVBEFS-UHFFFAOYSA-N 1-[(2,4-difluorophenyl)methyl]-6-[5-[5-(1-hydroxyethyl)-6-methylsulfonylpyridin-3-yl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C(O)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MLIQGTNYAVBEFS-UHFFFAOYSA-N 0.000 claims 1
SJNVBVHQEJDFEJ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-6-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(C(F)(F)F)C=N1 SJNVBVHQEJDFEJ-UHFFFAOYSA-N 0.000 claims 1
RFXUBTIREBPUFE-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-(3-propan-2-yl-4-pyrazin-2-yloxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CN=CC=N1 RFXUBTIREBPUFE-UHFFFAOYSA-N 0.000 claims 1
QIKPOFVHGPKCNH-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-(4-phenoxy-3-propan-2-ylphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC=CC=C1 QIKPOFVHGPKCNH-UHFFFAOYSA-N 0.000 claims 1
XPZLABCWUXIONZ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-(4-piperidin-4-yloxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1CCNCC1 XPZLABCWUXIONZ-UHFFFAOYSA-N 0.000 claims 1
QJWSTDAFUBFRHR-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-(4-pyrazin-2-yloxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CN=CC=N1 QJWSTDAFUBFRHR-UHFFFAOYSA-N 0.000 claims 1
ZOKMTRPWLXGPMU-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-(4-pyrimidin-2-yloxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC=CC=N1 ZOKMTRPWLXGPMU-UHFFFAOYSA-N 0.000 claims 1
VWDQVRJYWLVFOC-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-[3-(1h-pyrazol-4-yl)phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C2=CNN=C2)=C1 VWDQVRJYWLVFOC-UHFFFAOYSA-N 0.000 claims 1
GAPWRMWNVANLLT-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-[3-propan-2-yl-4-(3-propan-2-ylphenoxy)phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC=CC(OC=2C(=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C(C)C)=C1 GAPWRMWNVANLLT-UHFFFAOYSA-N 0.000 claims 1
JOEYYWNWRSNJLZ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-[3-propan-2-yl-4-(4-propan-2-ylphenoxy)phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(C(C)C)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C(C)C JOEYYWNWRSNJLZ-UHFFFAOYSA-N 0.000 claims 1
GRGIAKNFKFBDKR-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-[4-(3-phenylmethoxyphenoxy)-3-propan-2-ylphenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC(C=1)=CC=CC=1OCC1=CC=CC=C1 GRGIAKNFKFBDKR-UHFFFAOYSA-N 0.000 claims 1
XGEUUEOAOBVRIZ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-[4-(4-phenylmethoxyphenoxy)-3-propan-2-ylphenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC(C=C1)=CC=C1OCC1=CC=CC=C1 XGEUUEOAOBVRIZ-UHFFFAOYSA-N 0.000 claims 1
ZQDQWLNKNCLFCR-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-2-oxo-6-[4-[3-(piperidine-1-carbonyl)phenoxy]phenyl]-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(C(=O)N2CCCCC2)=C1 ZQDQWLNKNCLFCR-UHFFFAOYSA-N 0.000 claims 1
XRDPHSAGEWYBNJ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-(3-methyl-4-pyrazin-2-yloxyphenyl)-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CN=CC=N1 XRDPHSAGEWYBNJ-UHFFFAOYSA-N 0.000 claims 1
BUHGGSYTYFRNDP-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(1-methylindol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3C=CN(C)C3=CC=2)=C1 BUHGGSYTYFRNDP-UHFFFAOYSA-N 0.000 claims 1
VVUZQDGGAOSIKH-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(1-methylpyrazol-4-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C2=CN(C)N=C2)=C1 VVUZQDGGAOSIKH-UHFFFAOYSA-N 0.000 claims 1
VTBBDPXEGSBEPW-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(1h-indol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3C=CNC3=CC=2)=C1 VTBBDPXEGSBEPW-UHFFFAOYSA-N 0.000 claims 1
MMJHJZIZKQNWBM-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(1h-indol-6-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3NC=CC3=CC=2)=C1 MMJHJZIZKQNWBM-UHFFFAOYSA-N 0.000 claims 1
WDNUBWUHUPJCOU-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(3-hydroxyphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(O)C=CC=2)=C1 WDNUBWUHUPJCOU-UHFFFAOYSA-N 0.000 claims 1
BPRYDHPCKZNFRT-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(3-methylsulfonylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(C=CC=2)S(C)(=O)=O)=C1 BPRYDHPCKZNFRT-UHFFFAOYSA-N 0.000 claims 1
CSOINEXWNBYQRJ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(4-hydroxyphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=CC(O)=CC=2)=C1 CSOINEXWNBYQRJ-UHFFFAOYSA-N 0.000 claims 1
RJECKZGVSYRGEB-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-(4-methylsulfonylphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=CC(=CC=2)S(C)(=O)=O)=C1 RJECKZGVSYRGEB-UHFFFAOYSA-N 0.000 claims 1
CDRAAOOPTHWDAN-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-[1-(3-methylbutyl)pyrazol-4-yl]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=NN(CCC(C)C)C=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 CDRAAOOPTHWDAN-UHFFFAOYSA-N 0.000 claims 1
CNYDNBRRYDMDNM-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-methyl-4-(3-phenylmethoxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=CC(OCC=2C=CC=CC=2)=C1 CNYDNBRRYDMDNM-UHFFFAOYSA-N 0.000 claims 1
KVTLZORHWLZNPW-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-methyl-4-(3-propan-2-ylphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC=CC(OC=2C(=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C)=C1 KVTLZORHWLZNPW-UHFFFAOYSA-N 0.000 claims 1
GLTJTSYCEKDHDF-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-methyl-4-(4-phenylmethoxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC(C=C1)=CC=C1OCC1=CC=CC=C1 GLTJTSYCEKDHDF-UHFFFAOYSA-N 0.000 claims 1
PURAIPWSXBFEMN-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-methyl-4-[2-(trifluoromethyl)phenoxy]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=CC=C1C(F)(F)F PURAIPWSXBFEMN-UHFFFAOYSA-N 0.000 claims 1
AAPDCGOKHZYQTF-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[3-methyl-4-[3-(trifluoromethyl)phenoxy]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=CC(C(F)(F)F)=C1 AAPDCGOKHZYQTF-UHFFFAOYSA-N 0.000 claims 1
IJXBQPXOUWMKDE-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(1h-indol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3C=CNC3=CC=2)C=C1 IJXBQPXOUWMKDE-UHFFFAOYSA-N 0.000 claims 1
GTBQDPJWNXLCEN-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(1h-indol-5-yloxy)-3,5-dimethylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC(C)=C1OC1=CC=C(NC=C2)C2=C1 GTBQDPJWNXLCEN-UHFFFAOYSA-N 0.000 claims 1
YOGQVZPHHJIWNM-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(1h-indol-5-yloxy)-3-methylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=C(NC=C2)C2=C1 YOGQVZPHHJIWNM-UHFFFAOYSA-N 0.000 claims 1
UDJCFTXVQUXATQ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(1h-indol-5-yloxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC=C2)C2=C1 UDJCFTXVQUXATQ-UHFFFAOYSA-N 0.000 claims 1
MJGMZXZXCBCDBT-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(1h-indol-6-yl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3NC=CC3=CC=2)C=C1 MJGMZXZXCBCDBT-UHFFFAOYSA-N 0.000 claims 1
XGCPNUJOLWEHSX-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(2-ethyl-4-methylphenoxy)-3-methylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCC1=CC(C)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C XGCPNUJOLWEHSX-UHFFFAOYSA-N 0.000 claims 1
AAMWAEOOTUYQQC-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(2-ethyl-4-methylphenoxy)-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCC1=CC(C)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C(C)C AAMWAEOOTUYQQC-UHFFFAOYSA-N 0.000 claims 1
MXZJAZPTOWAKKV-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(2-ethylphenoxy)-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCC1=CC=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C(C)C MXZJAZPTOWAKKV-UHFFFAOYSA-N 0.000 claims 1
GXLQRCADEZUVSH-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(2-methylphenoxy)-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC=CC=C1C GXLQRCADEZUVSH-UHFFFAOYSA-N 0.000 claims 1
PXYMMQDEJMOINJ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(3,6-dimethylpyrazin-2-yl)oxy-3-methylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=NC(C)=CN=C1C PXYMMQDEJMOINJ-UHFFFAOYSA-N 0.000 claims 1
VQPQZTQVVXVMOH-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(3,6-dimethylpyrazin-2-yl)oxy-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=NC(C)=CN=C1C VQPQZTQVVXVMOH-UHFFFAOYSA-N 0.000 claims 1
CNVXQBAOTCOESF-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(3,6-dimethylpyrazin-2-yl)oxyphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC(C)=CN=C1C CNVXQBAOTCOESF-UHFFFAOYSA-N 0.000 claims 1
OMXSKVIEXRFKNQ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(3-hexoxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCCCCCOC1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 OMXSKVIEXRFKNQ-UHFFFAOYSA-N 0.000 claims 1
LQNIEKQFZPRYHE-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(3-hydroxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(O)=C1 LQNIEKQFZPRYHE-UHFFFAOYSA-N 0.000 claims 1
YJXKMYUBYDNTFW-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(3-hydroxyphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(O)C=CC=2)C=C1 YJXKMYUBYDNTFW-UHFFFAOYSA-N 0.000 claims 1
YTWVQCFGERNEGE-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(3-methylphenoxy)-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC=CC(C)=C1 YTWVQCFGERNEGE-UHFFFAOYSA-N 0.000 claims 1
LWFGKFUFYLLHGQ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4,6-dimethylpyrimidin-2-yl)oxyphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC(C)=CC(C)=N1 LWFGKFUFYLLHGQ-UHFFFAOYSA-N 0.000 claims 1
TUMIWMDCRBRMHI-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-ethenylphenoxy)-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC=C(C=C)C=C1 TUMIWMDCRBRMHI-UHFFFAOYSA-N 0.000 claims 1
AJXBAZASZMDDPN-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-ethyl-2-methylphenoxy)-3-methylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(CC)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C AJXBAZASZMDDPN-UHFFFAOYSA-N 0.000 claims 1
KJOGVCMVYJSXPP-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-ethyl-2-methylphenoxy)-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(CC)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C(C)C KJOGVCMVYJSXPP-UHFFFAOYSA-N 0.000 claims 1
PRLSQQVJBHDCSB-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-fluorophenoxy)-3-methylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=C(F)C=C1 PRLSQQVJBHDCSB-UHFFFAOYSA-N 0.000 claims 1
GSMHOPBTODYSNE-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-hexoxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(OCCCCCC)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1 GSMHOPBTODYSNE-UHFFFAOYSA-N 0.000 claims 1
LWAYNGWYZODLGO-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-hydroxyphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(O)C=C1 LWAYNGWYZODLGO-UHFFFAOYSA-N 0.000 claims 1
UORVXBAWQDZLJS-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-hydroxyphenyl)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=CC(O)=CC=2)C=C1 UORVXBAWQDZLJS-UHFFFAOYSA-N 0.000 claims 1
WXNLGFMTUFLSOQ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-methoxyphenoxy)-3-methylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(OC)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C WXNLGFMTUFLSOQ-UHFFFAOYSA-N 0.000 claims 1
VODQVMSCXYQROW-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-methylphenoxy)-3-propan-2-ylphenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC=C(C)C=C1 VODQVMSCXYQROW-UHFFFAOYSA-N 0.000 claims 1
ZUXFOAIUHQPOGM-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-(4-methylsulfanylphenoxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(SC)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1 ZUXFOAIUHQPOGM-UHFFFAOYSA-N 0.000 claims 1
XQKZIPCJZMWVEG-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-[3-(3-hydroxypiperidine-1-carbonyl)phenoxy]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(C(=O)N2CC(O)CCC2)=C1 XQKZIPCJZMWVEG-UHFFFAOYSA-N 0.000 claims 1
GKDCATQYXNHCNU-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-[3-(3-methylbutoxy)phenoxy]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)CCOC1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 GKDCATQYXNHCNU-UHFFFAOYSA-N 0.000 claims 1
YVMGKPUOQACJTM-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-[4-(1,3-dioxoisoindol-2-yl)phenoxy]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(N2C(C3=CC=CC=C3C2=O)=O)C=C1 YVMGKPUOQACJTM-UHFFFAOYSA-N 0.000 claims 1
ZVFYZUDFVXIIRZ-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[4-[4-(3-methylbutoxy)phenoxy]phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(OCCC(C)C)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1 ZVFYZUDFVXIIRZ-UHFFFAOYSA-N 0.000 claims 1
KCGCIHQPSKUSTN-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[5-(1h-indol-6-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3NC=CC3=CC=2)S1 KCGCIHQPSKUSTN-UHFFFAOYSA-N 0.000 claims 1
PJUVYAKGMQWCSS-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[5-(3-methylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 PJUVYAKGMQWCSS-UHFFFAOYSA-N 0.000 claims 1
BAJXPYOSUCWJBF-UHFFFAOYSA-N 1-[(2,4-dimethylphenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=CC=2)S(C)(=O)=O)S1 BAJXPYOSUCWJBF-UHFFFAOYSA-N 0.000 claims 1
XALXWSABBXMCMG-UHFFFAOYSA-N 1-[(2,5-diethyl-1,3-thiazol-4-yl)methyl]-2-oxo-6-(4-phenoxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound S1C(CC)=NC(CN2C(C(C#N)=C(C=C2C=2C=CC(OC=3C=CC=CC=3)=CC=2)C(F)(F)F)=O)=C1CC XALXWSABBXMCMG-UHFFFAOYSA-N 0.000 claims 1
PEXLLFXGAQPVCV-UHFFFAOYSA-N 1-[(2-chloro-4-fluorophenyl)methyl]-2-oxo-6-(4-phenoxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound ClC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC=C1 PEXLLFXGAQPVCV-UHFFFAOYSA-N 0.000 claims 1
CKSCDGUVBLVNIN-UHFFFAOYSA-N 1-[(2-chloro-4-fluorophenyl)methyl]-2-oxo-6-(4-phenylmethoxyphenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound ClC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OCC1=CC=CC=C1 CKSCDGUVBLVNIN-UHFFFAOYSA-N 0.000 claims 1
JHCHPDFKDUCMJG-UHFFFAOYSA-N 1-[(2-chloro-4-fluorophenyl)methyl]-6-[4-(1h-indol-5-yloxy)phenyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound ClC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC=C2)C2=C1 JHCHPDFKDUCMJG-UHFFFAOYSA-N 0.000 claims 1
RTAHEBMUBIXDHO-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-6-[5-(3-ethylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)Cl)=C1 RTAHEBMUBIXDHO-UHFFFAOYSA-N 0.000 claims 1
SNNVSTGXEMYVOD-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-6-[5-(3-ethylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)Cl)=C1 SNNVSTGXEMYVOD-UHFFFAOYSA-N 0.000 claims 1
VNOMANFPVITENJ-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-6-[5-(3-methylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)Cl)=C1 VNOMANFPVITENJ-UHFFFAOYSA-N 0.000 claims 1
YUZUHBVOLGOLIY-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)Cl)=C1 YUZUHBVOLGOLIY-UHFFFAOYSA-N 0.000 claims 1
APNYMKDWNLIVOZ-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)Cl)S1 APNYMKDWNLIVOZ-UHFFFAOYSA-N 0.000 claims 1
KQLGFWJGDATYJO-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-6-[5-(5-methyl-6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)Cl)=C1 KQLGFWJGDATYJO-UHFFFAOYSA-N 0.000 claims 1
LXERTQDOHCYHRH-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-6-[5-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)Cl)=C1 LXERTQDOHCYHRH-UHFFFAOYSA-N 0.000 claims 1
CQRVSSNIEGMLPV-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-6-[4-(3-methylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 CQRVSSNIEGMLPV-UHFFFAOYSA-N 0.000 claims 1
YWKMJOVZAPDGCK-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-6-[4-(4-methylsulfonylphenyl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 YWKMJOVZAPDGCK-UHFFFAOYSA-N 0.000 claims 1
VUQADFHKFDFDLF-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-6-[4-(5-methyl-6-methylsulfonylpyridin-3-yl)furan-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 VUQADFHKFDFDLF-UHFFFAOYSA-N 0.000 claims 1
GVXPYATXGCWTHO-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 GVXPYATXGCWTHO-UHFFFAOYSA-N 0.000 claims 1
UJZAEYGFDWYCSK-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)S1 UJZAEYGFDWYCSK-UHFFFAOYSA-N 0.000 claims 1
SHRGNVBEWDXVRV-UHFFFAOYSA-N 1-[(2-fluorophenyl)methyl]-6-[5-(5-methyl-6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 SHRGNVBEWDXVRV-UHFFFAOYSA-N 0.000 claims 1
FYPZUHLVUPTFJO-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-6-[5-(3-ethylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C=CC(Cl)=CC=2)=C1 FYPZUHLVUPTFJO-UHFFFAOYSA-N 0.000 claims 1
VUJNDABPPOEYGA-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-6-[5-(3-ethylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C=CC(Cl)=CC=2)=C1 VUJNDABPPOEYGA-UHFFFAOYSA-N 0.000 claims 1
NJIOVQVXIOWKRB-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C=CC(Cl)=CC=2)=C1 NJIOVQVXIOWKRB-UHFFFAOYSA-N 0.000 claims 1
KHLXMJWNSWDVKV-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C=CC(Cl)=CC=2)S1 KHLXMJWNSWDVKV-UHFFFAOYSA-N 0.000 claims 1
YWAMJMPYHROAHY-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-6-[5-(5-methyl-6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound N1=C(S(C)(=O)=O)C(C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C=CC(Cl)=CC=2)=C1 YWAMJMPYHROAHY-UHFFFAOYSA-N 0.000 claims 1
QOUFOUJBJZLGCR-UHFFFAOYSA-N 1-[(4-ethyl-2-fluorophenyl)methyl]-6-[5-(3-ethylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(CC)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=CC=2)S(=O)(=O)CC)S1 QOUFOUJBJZLGCR-UHFFFAOYSA-N 0.000 claims 1
PILCGHURXHYRSB-UHFFFAOYSA-N 1-[(4-ethyl-2-fluorophenyl)methyl]-6-[5-(3-methylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(CC)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(C)C)S(C)(=O)=O)S1 PILCGHURXHYRSB-UHFFFAOYSA-N 0.000 claims 1
CUEQVYOCASPJDE-UHFFFAOYSA-N 1-[(4-ethyl-2-fluorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(CC)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=CC=2)S(C)(=O)=O)S1 CUEQVYOCASPJDE-UHFFFAOYSA-N 0.000 claims 1
SRGKUBSBDMKQPY-UHFFFAOYSA-N 1-[(4-ethyl-2-fluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(CC)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=CC(=CC=2)S(C)(=O)=O)S1 SRGKUBSBDMKQPY-UHFFFAOYSA-N 0.000 claims 1
IIZKJZGRMWPXMK-UHFFFAOYSA-N 1-[(4-ethyl-2-fluorophenyl)methyl]-6-[5-(5-methyl-6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(CC)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C)C(=NC=2)S(C)(=O)=O)S1 IIZKJZGRMWPXMK-UHFFFAOYSA-N 0.000 claims 1
PWLQNAXUDVFZAT-UHFFFAOYSA-N 1-[(4-ethyl-2-fluorophenyl)methyl]-6-[5-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(CC)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC)S1 PWLQNAXUDVFZAT-UHFFFAOYSA-N 0.000 claims 1
RQPXHMDDVFSCJE-UHFFFAOYSA-N 1-[3-[3-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]-3-[3-(dimethylamino)propyl]urea Chemical compound CN(C)CCCNC(=O)NC1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 RQPXHMDDVFSCJE-UHFFFAOYSA-N 0.000 claims 1
WSSKGLUNLYTSEB-UHFFFAOYSA-N 1-[3-[3-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]-3-ethylurea Chemical compound CCNC(=O)NC1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 WSSKGLUNLYTSEB-UHFFFAOYSA-N 0.000 claims 1
WJLCFCAPZHNADK-UHFFFAOYSA-N 1-[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]-3-[4-(dimethylamino)butyl]urea Chemical compound CN(C)CCCCNC(=O)NC1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 WJLCFCAPZHNADK-UHFFFAOYSA-N 0.000 claims 1
LQMBBCXWBFACHX-UHFFFAOYSA-N 1-[4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]-3-(2,3-dihydroxypropoxy)urea Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=O)NOCC(O)CO)C=C1 LQMBBCXWBFACHX-UHFFFAOYSA-N 0.000 claims 1
MLNXLRYIHJIMEN-UHFFFAOYSA-N 1-[4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]-3-(2,3-dihydroxypropyl)urea Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=O)NCC(O)CO)C=C1 MLNXLRYIHJIMEN-UHFFFAOYSA-N 0.000 claims 1
GRIXIFLLMHXPGR-UHFFFAOYSA-N 1-[4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]-3-(2-hydroxyethyl)urea Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=O)NCCO)C=C1 GRIXIFLLMHXPGR-UHFFFAOYSA-N 0.000 claims 1
JVXGHVZSPPXQEE-UHFFFAOYSA-N 1-[4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]-3-[4-(dimethylamino)butyl]urea Chemical compound C1=CC(NC(=O)NCCCCN(C)C)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1 JVXGHVZSPPXQEE-UHFFFAOYSA-N 0.000 claims 1
FLBBIALBLJQSFV-UHFFFAOYSA-N 2-[2-chloro-4-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]acetic acid Chemical compound C1=C(Cl)C(CC(=O)O)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FLBBIALBLJQSFV-UHFFFAOYSA-N 0.000 claims 1
CIROKLNJVVDWKE-UHFFFAOYSA-N 2-[2-chloro-4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenoxy]acetic acid Chemical compound C1=C(Cl)C(OCC(=O)O)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 CIROKLNJVVDWKE-UHFFFAOYSA-N 0.000 claims 1
NXVYWHOMIRRGIT-UHFFFAOYSA-N 2-[3-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NXVYWHOMIRRGIT-UHFFFAOYSA-N 0.000 claims 1
OJVLADNLDKUKMU-UHFFFAOYSA-N 2-[3-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OJVLADNLDKUKMU-UHFFFAOYSA-N 0.000 claims 1
YONKHOBUCNWBCN-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-5-propan-2-yloxyphenyl]acetic acid Chemical compound CC(C)OC1=CC(CC(O)=O)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YONKHOBUCNWBCN-UHFFFAOYSA-N 0.000 claims 1
VMYCFHAVANSCTP-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-5-propan-2-ylphenyl]acetic acid Chemical compound CC(C)C1=CC(CC(O)=O)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VMYCFHAVANSCTP-UHFFFAOYSA-N 0.000 claims 1
WOCNCGZZBLRRKP-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-4-methoxyphenyl]acetic acid Chemical compound COC1=CC=C(CC(O)=O)C=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 WOCNCGZZBLRRKP-UHFFFAOYSA-N 0.000 claims 1
MHNQJUFTPAGXGO-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-5-propan-2-yloxyphenyl]acetic acid Chemical compound CC(C)OC1=CC(CC(O)=O)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MHNQJUFTPAGXGO-UHFFFAOYSA-N 0.000 claims 1
DYAJBNXCIBVTIX-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-5-propan-2-ylphenyl]acetic acid Chemical compound CC(C)C1=CC(CC(O)=O)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 DYAJBNXCIBVTIX-UHFFFAOYSA-N 0.000 claims 1
HNOGXGOTWNEFKQ-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HNOGXGOTWNEFKQ-UHFFFAOYSA-N 0.000 claims 1
HDCJYVMKJUDTEL-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-5-propan-2-yloxyphenyl]acetic acid Chemical compound CC(C)OC1=CC(CC(O)=O)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HDCJYVMKJUDTEL-UHFFFAOYSA-N 0.000 claims 1
QTGPUIZYFRRSNX-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-5-propan-2-ylphenyl]acetic acid Chemical compound CC(C)C1=CC(CC(O)=O)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QTGPUIZYFRRSNX-UHFFFAOYSA-N 0.000 claims 1
NRHHIBOLHOZSJI-UHFFFAOYSA-N 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NRHHIBOLHOZSJI-UHFFFAOYSA-N 0.000 claims 1
KAJFNNZWXHBBEL-UHFFFAOYSA-N 2-[4-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KAJFNNZWXHBBEL-UHFFFAOYSA-N 0.000 claims 1
RAACWIPJTVUCQG-UHFFFAOYSA-N 2-[4-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 RAACWIPJTVUCQG-UHFFFAOYSA-N 0.000 claims 1
COLVYIUPLILRJB-UHFFFAOYSA-N 2-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 COLVYIUPLILRJB-UHFFFAOYSA-N 0.000 claims 1
CWTCLHHCPFVYMK-UHFFFAOYSA-N 2-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 CWTCLHHCPFVYMK-UHFFFAOYSA-N 0.000 claims 1
YBMVWUBEIOUAIZ-UHFFFAOYSA-N 2-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YBMVWUBEIOUAIZ-UHFFFAOYSA-N 0.000 claims 1
HYDNJTOGYWJHIT-UHFFFAOYSA-N 2-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-2-methoxyphenyl]acetic acid Chemical compound C1=C(CC(O)=O)C(OC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HYDNJTOGYWJHIT-UHFFFAOYSA-N 0.000 claims 1
JRFGRDJABRGNFI-UHFFFAOYSA-N 2-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-2-methoxyphenyl]acetic acid Chemical compound C1=C(CC(O)=O)C(OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 JRFGRDJABRGNFI-UHFFFAOYSA-N 0.000 claims 1
LWKAKAWUJLXQRL-UHFFFAOYSA-N 2-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-2-methoxyphenyl]acetic acid Chemical compound C1=C(CC(O)=O)C(OC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 LWKAKAWUJLXQRL-UHFFFAOYSA-N 0.000 claims 1
BOIAGBNSIKYZBC-UHFFFAOYSA-N 2-[[1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]methyl]guanidine Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(C=2N(C(=O)C(CNC(N)=N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 BOIAGBNSIKYZBC-UHFFFAOYSA-N 0.000 claims 1
125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
NQHSQVJMWUUCLO-UHFFFAOYSA-N 3-(diethylaminomethyl)-1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-4-(trifluoromethyl)pyridin-2-one Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(CN(CC)CC)=C(C(F)(F)F)C=C1C(S1)=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 NQHSQVJMWUUCLO-UHFFFAOYSA-N 0.000 claims 1
AOXMJJPBGXDKRY-UHFFFAOYSA-N 3-[3-[3-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]-1,1-dimethylurea Chemical compound CN(C)C(=O)NC1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 AOXMJJPBGXDKRY-UHFFFAOYSA-N 0.000 claims 1
FICPIUHAEIYYAI-UHFFFAOYSA-N 3-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]-n-ethylbenzamide Chemical compound CCNC(=O)C1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FICPIUHAEIYYAI-UHFFFAOYSA-N 0.000 claims 1
WSFANDDYMPMBJO-UHFFFAOYSA-N 3-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WSFANDDYMPMBJO-UHFFFAOYSA-N 0.000 claims 1
JOBQDGQTKFEKEJ-UHFFFAOYSA-N 3-[3-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]-n-ethylbenzamide Chemical compound CCNC(=O)C1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 JOBQDGQTKFEKEJ-UHFFFAOYSA-N 0.000 claims 1
RXUKCFSIBVVWFP-UHFFFAOYSA-N 3-[3-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]-n-methylbenzamide Chemical compound CNC(=O)C1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 RXUKCFSIBVVWFP-UHFFFAOYSA-N 0.000 claims 1
YXUVUXZQQIIHPG-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-5-hydroxy-n,n-dimethylbenzamide Chemical compound CN(C)C(=O)C1=CC(O)=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YXUVUXZQQIIHPG-UHFFFAOYSA-N 0.000 claims 1
VDSKQPJRMAGGAR-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n,n-dimethyl-5-phenylmethoxybenzamide Chemical compound C=1C(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=CC(C(=O)N(C)C)=CC=1OCC1=CC=CC=C1 VDSKQPJRMAGGAR-UHFFFAOYSA-N 0.000 claims 1
FFNRKHHHDSZCOQ-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n,n-dimethylbenzamide Chemical compound CN(C)C(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FFNRKHHHDSZCOQ-UHFFFAOYSA-N 0.000 claims 1
WOGALCYIWDAKRN-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-methylbenzamide Chemical compound CNC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WOGALCYIWDAKRN-UHFFFAOYSA-N 0.000 claims 1
KVSFBYYAAVLPFK-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n'-phenylbenzohydrazide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(C(=O)NNC=2C=CC=CC=2)=C1 KVSFBYYAAVLPFK-UHFFFAOYSA-N 0.000 claims 1
OJUIPJFJTPFAOW-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n,n-dimethylbenzamide Chemical compound CN(C)C(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 OJUIPJFJTPFAOW-UHFFFAOYSA-N 0.000 claims 1
LWCOTPMBZGVTBB-VWLOTQADSA-N 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-[(1s)-1-phenylethyl]benzamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(=O)C(C=1)=CC=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C LWCOTPMBZGVTBB-VWLOTQADSA-N 0.000 claims 1
LPKNEPRVIDEUSA-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-cyclopentylbenzamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(C(=O)NC2CCCC2)=C1 LPKNEPRVIDEUSA-UHFFFAOYSA-N 0.000 claims 1
ODIVJCJODRWCPV-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-methoxy-n-methylbenzamide Chemical compound CON(C)C(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 ODIVJCJODRWCPV-UHFFFAOYSA-N 0.000 claims 1
DDHSXWLKWLFGKA-UHFFFAOYSA-N 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-methylbenzamide Chemical compound CNC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 DDHSXWLKWLFGKA-UHFFFAOYSA-N 0.000 claims 1
GLEFSHORNOYZDR-UHFFFAOYSA-N 3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]benzoic acid Chemical compound OC(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 GLEFSHORNOYZDR-UHFFFAOYSA-N 0.000 claims 1
BVIXCYIDLWXCBE-UHFFFAOYSA-N 4-(1,1-difluoro-3-methylbutyl)-1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethylsulfonylphenyl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)CC(C)C)CC=2C(=CC(F)=CC=2)F)=C1 BVIXCYIDLWXCBE-UHFFFAOYSA-N 0.000 claims 1
DTAPGEFNZXILGY-UHFFFAOYSA-N 4-(1,1-difluoro-3-methylbutyl)-1-[(2,4-difluorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CC(C)C)C=C1C(S1)=CC=C1C1=CC=CC(S(C)(=O)=O)=C1 DTAPGEFNZXILGY-UHFFFAOYSA-N 0.000 claims 1
ZBIOGIRCVFDKLQ-UHFFFAOYSA-N 4-(1,1-difluoro-3-methylbutyl)-1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CC(C)C)C=C1C(S1)=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 ZBIOGIRCVFDKLQ-UHFFFAOYSA-N 0.000 claims 1
RKOHXBVJWKHDHI-UHFFFAOYSA-N 4-(1,1-difluoroheptyl)-1-[(2,4-difluorophenyl)methyl]-6-[5-(3-ethylsulfonylphenyl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CCCCCC)C=C1C(S1)=CC=C1C1=CC=CC(S(=O)(=O)CC)=C1 RKOHXBVJWKHDHI-UHFFFAOYSA-N 0.000 claims 1
OHQVEUIFFMHCNI-UHFFFAOYSA-N 4-(1,1-difluoroheptyl)-1-[(2,4-difluorophenyl)methyl]-6-[5-(3-methylsulfonylphenyl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CCCCCC)C=C1C(S1)=CC=C1C1=CC=CC(S(C)(=O)=O)=C1 OHQVEUIFFMHCNI-UHFFFAOYSA-N 0.000 claims 1
ZMWWGVNWIJARAS-UHFFFAOYSA-N 4-(1,1-difluoroheptyl)-1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CCCCCC)C=C1C(S1)=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 ZMWWGVNWIJARAS-UHFFFAOYSA-N 0.000 claims 1
KOPNQYPZONJFFE-UHFFFAOYSA-N 4-(1,1-difluoropropyl)-1-[(2-fluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=CC=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CC)C=C1C(S1)=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 KOPNQYPZONJFFE-UHFFFAOYSA-N 0.000 claims 1
LXHUUBDNMPVMMM-UHFFFAOYSA-N 4-(1,1-difluoropropyl)-1-[(2-fluorophenyl)methyl]-6-[5-(5-methyl-6-methylsulfonylpyridin-3-yl)thiophen-2-yl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=CC=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CC)C=C1C(S1)=CC=C1C1=CN=C(S(C)(=O)=O)C(C)=C1 LXHUUBDNMPVMMM-UHFFFAOYSA-N 0.000 claims 1
JFUVBKKECSMOOE-UHFFFAOYSA-N 4-(1,1-difluoropropyl)-6-[5-(3-ethylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-1-[(2-fluorophenyl)methyl]-2-oxopyridine-3-carbonitrile Chemical compound C=1C=CC=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CC)C=C1C(S1)=CC=C1C1=CC(C(C)C)=CC(S(=O)(=O)CC)=C1 JFUVBKKECSMOOE-UHFFFAOYSA-N 0.000 claims 1
ODOFCQIMUAMEHL-UHFFFAOYSA-N 4-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]-n-methylbenzamide Chemical compound C1=CC(C(=O)NC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ODOFCQIMUAMEHL-UHFFFAOYSA-N 0.000 claims 1
BIPSYGIVLRGTAC-UHFFFAOYSA-N 4-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]benzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BIPSYGIVLRGTAC-UHFFFAOYSA-N 0.000 claims 1
QJSPFCGMCKEMDN-UHFFFAOYSA-N 4-[3-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]-n-ethylbenzamide Chemical compound C1=CC(C(=O)NCC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 QJSPFCGMCKEMDN-UHFFFAOYSA-N 0.000 claims 1
VAMOFGNAIXBMMB-UHFFFAOYSA-N 4-[3-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]benzamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=CC(=CC=2)C(N)=O)=C1 VAMOFGNAIXBMMB-UHFFFAOYSA-N 0.000 claims 1
ZVROFBHKSPBOPF-UHFFFAOYSA-N 4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoic acid Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(C(O)=O)C=C1 ZVROFBHKSPBOPF-UHFFFAOYSA-N 0.000 claims 1
SQJGSTNFGRILOP-UHFFFAOYSA-N 4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 SQJGSTNFGRILOP-UHFFFAOYSA-N 0.000 claims 1
RLRHSTKAOFPEDJ-UHFFFAOYSA-N 5-[4-[1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-1h-indole-2-carboxylic acid Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=C2)C(O)=O)C2=C1 RLRHSTKAOFPEDJ-UHFFFAOYSA-N 0.000 claims 1
QNAWNMVONJZNRU-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-2-hydroxy-n,n-dimethylbenzamide Chemical compound C1=C(O)C(C(=O)N(C)C)=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QNAWNMVONJZNRU-UHFFFAOYSA-N 0.000 claims 1
PWTYWEOWQWSHPH-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n,n-dimethyl-2-phenylmethoxybenzamide Chemical compound C=1C=C(OCC=2C=CC=CC=2)C(C(=O)N(C)C)=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(F)C=C1F PWTYWEOWQWSHPH-UHFFFAOYSA-N 0.000 claims 1
FSILZOAHUYGQNX-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]anilino]-1h-indole-2-carboxylic acid Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1NC1=CC=C(NC(=C2)C(O)=O)C2=C1 FSILZOAHUYGQNX-UHFFFAOYSA-N 0.000 claims 1
PDSZIKWLDVRICO-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-1h-indole-2-carboxylic acid Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=C2)C(O)=O)C2=C1 PDSZIKWLDVRICO-UHFFFAOYSA-N 0.000 claims 1
OHQACFBNQIMHMZ-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n,n-dimethyl-1h-indole-2-carboxamide Chemical compound C=1C=C2NC(C(=O)N(C)C)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C OHQACFBNQIMHMZ-UHFFFAOYSA-N 0.000 claims 1
HANYUXHUYMGRQW-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-(2,3-dihydroxypropoxy)-1h-indole-2-carboxamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=C2)C(=O)NOCC(O)CO)C2=C1 HANYUXHUYMGRQW-UHFFFAOYSA-N 0.000 claims 1
SETGCGNOTCRACX-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-(2,3-dihydroxypropyl)-1h-indole-2-carboxamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=C2)C(=O)NCC(O)CO)C2=C1 SETGCGNOTCRACX-UHFFFAOYSA-N 0.000 claims 1
UXPOIGCRRYCVEC-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-(2-hydroxyethyl)-1h-indole-2-carboxamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=C2)C(=O)NCCO)C2=C1 UXPOIGCRRYCVEC-UHFFFAOYSA-N 0.000 claims 1
KONLATUWGOWLAI-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-(2-methylpropyl)-1h-indole-2-carboxamide Chemical compound C=1C=C2NC(C(=O)NCC(C)C)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C KONLATUWGOWLAI-UHFFFAOYSA-N 0.000 claims 1
OWAVRHNNAXIMSK-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-[3-(dimethylamino)propyl]-1h-indole-2-carboxamide Chemical compound C=1C=C2NC(C(=O)NCCCN(C)C)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C OWAVRHNNAXIMSK-UHFFFAOYSA-N 0.000 claims 1
BKZHMMSOJYKFLY-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-ethyl-1h-indole-2-carboxamide Chemical compound C=1C=C2NC(C(=O)NCC)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C BKZHMMSOJYKFLY-UHFFFAOYSA-N 0.000 claims 1
CFZUVUBXAGTJCK-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-propan-2-yl-1h-indole-2-carboxamide Chemical compound C=1C=C2NC(C(=O)NC(C)C)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C CFZUVUBXAGTJCK-UHFFFAOYSA-N 0.000 claims 1
XOKVCIDUHAACMG-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-n-propyl-1h-indole-2-carboxamide Chemical compound C=1C=C2NC(C(=O)NCCC)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C XOKVCIDUHAACMG-UHFFFAOYSA-N 0.000 claims 1
KVKHZEGBEWISJZ-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]-1h-indole-2-carboxylic acid Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3C=C(NC3=CC=2)C(O)=O)C=C1 KVKHZEGBEWISJZ-UHFFFAOYSA-N 0.000 claims 1
DYLDKZVAKKPTJX-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(2,6-dimethylpyridin-3-yl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-1H-indole-2-carboxylic acid Chemical compound CC1=NC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=C2)C(O)=O)C2=C1 DYLDKZVAKKPTJX-UHFFFAOYSA-N 0.000 claims 1
SPBBKYRUOXEOLR-UHFFFAOYSA-N 5-[4-[5-cyano-1-[(4-methoxy-2-methylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-1H-indole-2-carboxylic acid Chemical compound CC1=C(C=CC(=C1)OC)CN2C(=CC(=C(C2=O)C#N)C(F)(F)F)C3=CC=C(C=C3)OC4=CC5=C(C=C4)NC(=C5)C(=O)O SPBBKYRUOXEOLR-UHFFFAOYSA-N 0.000 claims 1
OTLCOYQFZMMONQ-UHFFFAOYSA-N 6-(1-benzylpyrazol-4-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C=1C=C(Cl)C=C(Cl)C=1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(=C1)C=NN1CC1=CC=CC=C1 OTLCOYQFZMMONQ-UHFFFAOYSA-N 0.000 claims 1
JOOVUGIIQUKORK-UHFFFAOYSA-N 6-(1-benzylpyrazol-4-yl)-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(CC=2C=CC=CC=2)N=C1 JOOVUGIIQUKORK-UHFFFAOYSA-N 0.000 claims 1
GOXKDRHNZASMCA-UHFFFAOYSA-N 6-(3-chloro-4-phenylmethoxyphenyl)-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1Cl)=CC=C1OCC1=CC=CC=C1 GOXKDRHNZASMCA-UHFFFAOYSA-N 0.000 claims 1
OJGJQYHNLPAXNJ-UHFFFAOYSA-N 6-(3-chloro-4-pyrazin-2-yloxyphenyl)-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1Cl)=CC=C1OC1=CN=CC=N1 OJGJQYHNLPAXNJ-UHFFFAOYSA-N 0.000 claims 1
OEBAFOFCOMOZMA-UHFFFAOYSA-N 6-(3-chloro-4-pyrimidin-2-yloxyphenyl)-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1Cl)=CC=C1OC1=NC=CC=N1 OEBAFOFCOMOZMA-UHFFFAOYSA-N 0.000 claims 1
UVBJXHWHMZFSFA-UHFFFAOYSA-N 6-[1-(3-chloro-4-cyanophenyl)pyrazol-4-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(C=2C=C(Cl)C(C#N)=CC=2)N=C1 UVBJXHWHMZFSFA-UHFFFAOYSA-N 0.000 claims 1
WDLXXVIMCGITJM-UHFFFAOYSA-N 6-[1-(3-chloro-4-ethoxyphenyl)pyrazol-4-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(OCC)=CC=C1N1N=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WDLXXVIMCGITJM-UHFFFAOYSA-N 0.000 claims 1
NBCKFZXDKRUZSC-UHFFFAOYSA-N 6-[1-[3-cyano-4-(trifluoromethyl)phenyl]pyrazol-4-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(C=2C=C(C(=CC=2)C(F)(F)F)C#N)N=C1 NBCKFZXDKRUZSC-UHFFFAOYSA-N 0.000 claims 1
GBMFXSQSNTZQSR-UHFFFAOYSA-N 6-[1-[4-cyano-3-(trifluoromethyl)phenyl]pyrazol-4-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CN(C=2C=C(C(C#N)=CC=2)C(F)(F)F)N=C1 GBMFXSQSNTZQSR-UHFFFAOYSA-N 0.000 claims 1
NPCXPFUEDXVZKE-UHFFFAOYSA-N 6-[3-(1,3-benzodioxol-5-yl)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3OCOC3=CC=2)=C1 NPCXPFUEDXVZKE-UHFFFAOYSA-N 0.000 claims 1
LJCKIVDAPODFNQ-UHFFFAOYSA-N 6-[3-(1-benzylpyrazol-4-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C2=CN(CC=3C=CC=CC=3)N=C2)=C1 LJCKIVDAPODFNQ-UHFFFAOYSA-N 0.000 claims 1
YYMRDLUVYPBFBL-UHFFFAOYSA-N 6-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3OCCOC3=CC=2)=C1 YYMRDLUVYPBFBL-UHFFFAOYSA-N 0.000 claims 1
UJSXWLYEYRWNST-UHFFFAOYSA-N 6-[3-(3,4-dimethoxyphenyl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 UJSXWLYEYRWNST-UHFFFAOYSA-N 0.000 claims 1
UXPLACYFJRNUTE-UHFFFAOYSA-N 6-[3-(3-acetyl-4-hydroxyphenyl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(O)C(C(=O)C)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 UXPLACYFJRNUTE-UHFFFAOYSA-N 0.000 claims 1
CXIZZMCKMBSVTI-UHFFFAOYSA-N 6-[3-(3-acetylphenyl)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(=O)C1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CXIZZMCKMBSVTI-UHFFFAOYSA-N 0.000 claims 1
JFKMOWZLFHPJAW-UHFFFAOYSA-N 6-[3-(3-acetylphenyl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(=O)C1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 JFKMOWZLFHPJAW-UHFFFAOYSA-N 0.000 claims 1
JSCLKGMBOZUSRX-UHFFFAOYSA-N 6-[3-(3-amino-4-ethoxyphenyl)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(N)C(OCC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JSCLKGMBOZUSRX-UHFFFAOYSA-N 0.000 claims 1
VLJPFZLZTCJSGZ-UHFFFAOYSA-N 6-[3-(3-aminophenyl)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound NC1=CC=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VLJPFZLZTCJSGZ-UHFFFAOYSA-N 0.000 claims 1
UDCPEPOMQTVAAV-UHFFFAOYSA-N 6-[3-(3-aminophenyl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(N)C=CC=2)=C1 UDCPEPOMQTVAAV-UHFFFAOYSA-N 0.000 claims 1
HNGLHIGMUNUROA-UHFFFAOYSA-N 6-[3-(3-chloro-4-ethoxyphenyl)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(OCC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HNGLHIGMUNUROA-UHFFFAOYSA-N 0.000 claims 1
JAIQYFDTZKQYTR-UHFFFAOYSA-N 6-[3-(3h-benzimidazol-5-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3N=CNC3=CC=2)=C1 JAIQYFDTZKQYTR-UHFFFAOYSA-N 0.000 claims 1
AGRLPYZKZBIXIX-UHFFFAOYSA-N 6-[3-(4-acetylphenyl)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(C(=O)C)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 AGRLPYZKZBIXIX-UHFFFAOYSA-N 0.000 claims 1
YRJXCNJMQBDFJR-UHFFFAOYSA-N 6-[3-(4-acetylphenyl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(C(=O)C)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 YRJXCNJMQBDFJR-UHFFFAOYSA-N 0.000 claims 1
JHJAGIHPPBXNLE-UHFFFAOYSA-N 6-[3-[3,5-bis(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)=C1 JHJAGIHPPBXNLE-UHFFFAOYSA-N 0.000 claims 1
GWVPAYKVGVKTAN-UHFFFAOYSA-N 6-[3-[3-(cyclopropylmethylsulfinyl)-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(C=C(C=2)S(=O)CC2CC2)C(F)(F)F)=C1 GWVPAYKVGVKTAN-UHFFFAOYSA-N 0.000 claims 1
HABJJFWKLPFNFK-UHFFFAOYSA-N 6-[3-[3-(cyclopropylmethylsulfonyl)-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC2CC2)=C1 HABJJFWKLPFNFK-UHFFFAOYSA-N 0.000 claims 1
MUZYRLATZAEDOM-UHFFFAOYSA-N 6-[3-[3-benzylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(C=C(C=2)S(=O)CC=2C=CC=CC=2)C(F)(F)F)=C1 MUZYRLATZAEDOM-UHFFFAOYSA-N 0.000 claims 1
DTSHODDOCNPLDE-UHFFFAOYSA-N 6-[3-[3-benzylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC=2C=CC=CC=2)=C1 DTSHODDOCNPLDE-UHFFFAOYSA-N 0.000 claims 1
RTKICPJPQSLQEN-UHFFFAOYSA-N 6-[3-[3-butylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCCC)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 RTKICPJPQSLQEN-UHFFFAOYSA-N 0.000 claims 1
OTHUPFHOIYXUMJ-UHFFFAOYSA-N 6-[3-[3-butylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCCC)=CC(C=2C=C(C=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OTHUPFHOIYXUMJ-UHFFFAOYSA-N 0.000 claims 1
UTMYUIBWCAKQIK-UHFFFAOYSA-N 6-[3-chloro-4-(3-cyanopyridin-2-yl)oxyphenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1Cl)=CC=C1OC1=NC=CC=C1C#N UTMYUIBWCAKQIK-UHFFFAOYSA-N 0.000 claims 1
YLZYGJMMPPUTBL-UHFFFAOYSA-N 6-[3-chloro-4-(4-fluorophenoxy)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(F)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1Cl YLZYGJMMPPUTBL-UHFFFAOYSA-N 0.000 claims 1
RXSXHJIFTDAGIU-UHFFFAOYSA-N 6-[3-chloro-4-(4-methylsulfonylphenoxy)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1Cl RXSXHJIFTDAGIU-UHFFFAOYSA-N 0.000 claims 1
BERDWDXCCQAMCL-UHFFFAOYSA-N 6-[4-(1,3-benzodioxol-5-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3OCOC3=CC=2)C=C1 BERDWDXCCQAMCL-UHFFFAOYSA-N 0.000 claims 1
WYRYIONTXZFBEK-UHFFFAOYSA-N 6-[4-(1,3-benzodioxol-5-yl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C3OCOC3=CC=2)=CS1 WYRYIONTXZFBEK-UHFFFAOYSA-N 0.000 claims 1
QDWFVUQNYRNNKK-UHFFFAOYSA-N 6-[4-(2,4-dimethylphenoxy)-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=C(C)C=C1C QDWFVUQNYRNNKK-UHFFFAOYSA-N 0.000 claims 1
OGFSAWLNUMJZCM-UHFFFAOYSA-N 6-[4-(2,4-dimethylphenoxy)-3-propan-2-ylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC=C(C)C=C1C OGFSAWLNUMJZCM-UHFFFAOYSA-N 0.000 claims 1
IYSMEYMSZBJKSD-UHFFFAOYSA-N 6-[4-(2,4-dimethylphenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(C)C=C1C IYSMEYMSZBJKSD-UHFFFAOYSA-N 0.000 claims 1
OLWJBPMSGTYDPU-UHFFFAOYSA-N 6-[4-(2,5-dimethylphenoxy)-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC(C)=CC=C1C OLWJBPMSGTYDPU-UHFFFAOYSA-N 0.000 claims 1
SKFWQJAVUUHPBH-UHFFFAOYSA-N 6-[4-(2,5-dimethylphenoxy)-3-propan-2-ylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC(C)=CC=C1C SKFWQJAVUUHPBH-UHFFFAOYSA-N 0.000 claims 1
FQLYLVKLFFFVPF-UHFFFAOYSA-N 6-[4-(2,6-dimethylphenoxy)-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=C(C)C=CC=C1C FQLYLVKLFFFVPF-UHFFFAOYSA-N 0.000 claims 1
LXSUDYSGUCXQCS-UHFFFAOYSA-N 6-[4-(2-chlorophenoxy)-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=CC=C1Cl LXSUDYSGUCXQCS-UHFFFAOYSA-N 0.000 claims 1
QMVXLZJEQBISMK-UHFFFAOYSA-N 6-[4-(3-amino-4-ethoxyphenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(N)C(OCC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QMVXLZJEQBISMK-UHFFFAOYSA-N 0.000 claims 1
ZOAMHYOKMKHNAV-UHFFFAOYSA-N 6-[4-(3-aminophenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(N)=C1 ZOAMHYOKMKHNAV-UHFFFAOYSA-N 0.000 claims 1
PWFRAOKKYVPTIA-UHFFFAOYSA-N 6-[4-(3-bromophenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(Br)=C1 PWFRAOKKYVPTIA-UHFFFAOYSA-N 0.000 claims 1
JAXIURPXPITDMH-UHFFFAOYSA-N 6-[4-(3-chloro-4-cyanophenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(Cl)C(C#N)=CC=2)=CO1 JAXIURPXPITDMH-UHFFFAOYSA-N 0.000 claims 1
SEGSQAAQAADZTL-UHFFFAOYSA-N 6-[4-(3-chloro-4-ethoxyphenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(OCC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 SEGSQAAQAADZTL-UHFFFAOYSA-N 0.000 claims 1
QKYZSECGGVCFHK-UHFFFAOYSA-N 6-[4-(3-chloro-4-ethoxyphenyl)phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 QKYZSECGGVCFHK-UHFFFAOYSA-N 0.000 claims 1
HLIYKBOOUOEDGM-UHFFFAOYSA-N 6-[4-(3-chloro-4-ethoxyphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(OCC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HLIYKBOOUOEDGM-UHFFFAOYSA-N 0.000 claims 1
BLFWFQUVWWBTDA-UHFFFAOYSA-N 6-[4-(3-chloro-4-methylphenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(C)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 BLFWFQUVWWBTDA-UHFFFAOYSA-N 0.000 claims 1
WKIZOEFQRHNMDY-UHFFFAOYSA-N 6-[4-(3-chloro-4-methylphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(C)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WKIZOEFQRHNMDY-UHFFFAOYSA-N 0.000 claims 1
HRTVFAWUYFPTJO-UHFFFAOYSA-N 6-[4-(3-chlorophenoxy)-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=CC(Cl)=C1 HRTVFAWUYFPTJO-UHFFFAOYSA-N 0.000 claims 1
LACNWTAXEHYZDW-UHFFFAOYSA-N 6-[4-(3-chloropyrazin-2-yl)oxy-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=NC=CN=C1Cl LACNWTAXEHYZDW-UHFFFAOYSA-N 0.000 claims 1
KPGWOQSWIIZFAP-UHFFFAOYSA-N 6-[4-(3-chloropyrazin-2-yl)oxy-3-propan-2-ylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=NC=CN=C1Cl KPGWOQSWIIZFAP-UHFFFAOYSA-N 0.000 claims 1
ZPPMWBMVDADIJJ-UHFFFAOYSA-N 6-[4-(3-chloropyrazin-2-yl)oxyphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC=CN=C1Cl ZPPMWBMVDADIJJ-UHFFFAOYSA-N 0.000 claims 1
HPUJJZRBDMNGMT-UHFFFAOYSA-N 6-[4-(3-cyano-6-methylpyridin-2-yl)oxy-3-propan-2-ylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=NC(C)=CC=C1C#N HPUJJZRBDMNGMT-UHFFFAOYSA-N 0.000 claims 1
PSAUWGRXSDYCOI-UHFFFAOYSA-N 6-[4-(3-cyano-6-methylpyridin-2-yl)oxyphenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC=C(C#N)C(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=N1 PSAUWGRXSDYCOI-UHFFFAOYSA-N 0.000 claims 1
YIVRMQGFKYICTC-UHFFFAOYSA-N 6-[4-(3-cyano-6-methylpyridin-2-yl)oxyphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC(C)=CC=C1C#N YIVRMQGFKYICTC-UHFFFAOYSA-N 0.000 claims 1
ACNCUZVYKVPOST-UHFFFAOYSA-N 6-[4-(3-cyanophenoxy)-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=CC(C#N)=C1 ACNCUZVYKVPOST-UHFFFAOYSA-N 0.000 claims 1
KIBXQACXRQXBLL-UHFFFAOYSA-N 6-[4-(3-cyanophenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(C#N)=C1 KIBXQACXRQXBLL-UHFFFAOYSA-N 0.000 claims 1
KOEDQNFPEKNLPD-UHFFFAOYSA-N 6-[4-(3-cyanopyridin-2-yl)oxyphenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC=CC=C1C#N KOEDQNFPEKNLPD-UHFFFAOYSA-N 0.000 claims 1
XBKGLGHGDKMWSX-UHFFFAOYSA-N 6-[4-(3-cyanopyridin-2-yl)oxyphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=NC=CC=C1C#N XBKGLGHGDKMWSX-UHFFFAOYSA-N 0.000 claims 1
CIWWKGQRNHRHBV-UHFFFAOYSA-N 6-[4-(3-ethylsulfonylphenyl)furan-2-yl]-1-[(2-fluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 CIWWKGQRNHRHBV-UHFFFAOYSA-N 0.000 claims 1
STNDQAHMBPTTOL-UHFFFAOYSA-N 6-[4-(3-tert-butyl-5-methylsulfonylphenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)(C)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 STNDQAHMBPTTOL-UHFFFAOYSA-N 0.000 claims 1
IYBJFRWQCIOPHM-UHFFFAOYSA-N 6-[4-(3-tert-butyl-5-methylsulfonylphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)(C)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IYBJFRWQCIOPHM-UHFFFAOYSA-N 0.000 claims 1
MYWIWHGNDYJCPP-UHFFFAOYSA-N 6-[4-(3h-benzimidazol-5-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3N=CNC3=CC=2)C=C1 MYWIWHGNDYJCPP-UHFFFAOYSA-N 0.000 claims 1
HYIVMQKSBNPENN-UHFFFAOYSA-N 6-[4-(4-amino-3-chlorophenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(N)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HYIVMQKSBNPENN-UHFFFAOYSA-N 0.000 claims 1
LCZDGXWPXWKQEB-UHFFFAOYSA-N 6-[4-(4-aminophenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(N)C=C1 LCZDGXWPXWKQEB-UHFFFAOYSA-N 0.000 claims 1
QQFBRWTZKFNXRD-UHFFFAOYSA-N 6-[4-(4-aminophenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]pyridin-2-one Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C=CC=C1C(C=C1)=CC=C1OC1=CC=C(N)C=C1 QQFBRWTZKFNXRD-UHFFFAOYSA-N 0.000 claims 1
MHLPCRFKFJSFDZ-UHFFFAOYSA-N 6-[4-(4-bromophenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(Br)C=C1 MHLPCRFKFJSFDZ-UHFFFAOYSA-N 0.000 claims 1
KZIFTDVRZXSGFV-UHFFFAOYSA-N 6-[4-(4-cyanophenoxy)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(C#N)C=C1 KZIFTDVRZXSGFV-UHFFFAOYSA-N 0.000 claims 1
CIYBWNVKPJKHRL-UHFFFAOYSA-N 6-[4-(4-tert-butylphenoxy)-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CC=C(C(C)(C)C)C=C1 CIYBWNVKPJKHRL-UHFFFAOYSA-N 0.000 claims 1
YNIUTWAJBOJVLY-UHFFFAOYSA-N 6-[4-(4-tert-butylphenoxy)-3-propan-2-ylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CC=C(C(C)(C)C)C=C1 YNIUTWAJBOJVLY-UHFFFAOYSA-N 0.000 claims 1
JADAGSPFZVUWAT-UHFFFAOYSA-N 6-[4-(5-cyano-6-ethoxypyridin-3-yl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C#N)C(OCC)=NC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JADAGSPFZVUWAT-UHFFFAOYSA-N 0.000 claims 1
XWSJESQYSNYJDX-UHFFFAOYSA-N 6-[4-(5-cyano-6-ethoxypyridin-3-yl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C#N)C(OCC)=NC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 XWSJESQYSNYJDX-UHFFFAOYSA-N 0.000 claims 1
JZCSIXMDRJWTNF-UHFFFAOYSA-N 6-[4-(6-chloropyrazin-2-yl)oxy-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1C)=CC=C1OC1=CN=CC(Cl)=N1 JZCSIXMDRJWTNF-UHFFFAOYSA-N 0.000 claims 1
NQQAOVSPKVGQHG-UHFFFAOYSA-N 6-[4-(6-chloropyrazin-2-yl)oxy-3-propan-2-ylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC(C)C1=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC=C1OC1=CN=CC(Cl)=N1 NQQAOVSPKVGQHG-UHFFFAOYSA-N 0.000 claims 1
NQCKIYVDTSHPTQ-UHFFFAOYSA-N 6-[4-(6-chloropyrazin-2-yl)oxyphenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CN=CC(Cl)=N1 NQCKIYVDTSHPTQ-UHFFFAOYSA-N 0.000 claims 1
CCXUMALKMSAABI-UHFFFAOYSA-N 6-[4-(6-chloropyrazin-2-yl)oxyphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CN=CC(Cl)=N1 CCXUMALKMSAABI-UHFFFAOYSA-N 0.000 claims 1
DNKWARZAXDLVDI-UHFFFAOYSA-N 6-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 DNKWARZAXDLVDI-UHFFFAOYSA-N 0.000 claims 1
YFWWXMDKCCKEFR-UHFFFAOYSA-N 6-[4-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)=CO1 YFWWXMDKCCKEFR-UHFFFAOYSA-N 0.000 claims 1
FMTJHRGJAVTJRS-UHFFFAOYSA-N 6-[4-[3,5-bis(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)C=C1 FMTJHRGJAVTJRS-UHFFFAOYSA-N 0.000 claims 1
SRPAXXVTZSQCBN-UHFFFAOYSA-N 6-[4-[3,5-bis(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)=CS1 SRPAXXVTZSQCBN-UHFFFAOYSA-N 0.000 claims 1
ZQFOPQXVEHFMAJ-UHFFFAOYSA-N 6-[4-[3-(cyclopropylmethylsulfinyl)-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)S(=O)CC2CC2)C(F)(F)F)C=C1 ZQFOPQXVEHFMAJ-UHFFFAOYSA-N 0.000 claims 1
BDYVPFSKLFGUES-UHFFFAOYSA-N 6-[4-[3-(cyclopropylmethylsulfinyl)-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(C=C(C=2)S(=O)CC2CC2)C(F)(F)F)=CS1 BDYVPFSKLFGUES-UHFFFAOYSA-N 0.000 claims 1
JFOAOVNNXOGZMX-UHFFFAOYSA-N 6-[4-[3-(cyclopropylmethylsulfonyl)-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC2CC2)C=C1 JFOAOVNNXOGZMX-UHFFFAOYSA-N 0.000 claims 1
DDNPAGYUANRAID-UHFFFAOYSA-N 6-[4-[3-(cyclopropylmethylsulfonyl)-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC2CC2)=CS1 DDNPAGYUANRAID-UHFFFAOYSA-N 0.000 claims 1
UWNMQOOHTHHREU-UHFFFAOYSA-N 6-[4-[3-benzylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)S(=O)CC=2C=CC=CC=2)C(F)(F)F)C=C1 UWNMQOOHTHHREU-UHFFFAOYSA-N 0.000 claims 1
CGNLWICCMUKVSH-UHFFFAOYSA-N 6-[4-[3-benzylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(C=C(C=2)S(=O)CC=2C=CC=CC=2)C(F)(F)F)=CS1 CGNLWICCMUKVSH-UHFFFAOYSA-N 0.000 claims 1
RYFQOXKTJNEOPK-UHFFFAOYSA-N 6-[4-[3-benzylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC=2C=CC=CC=2)C=C1 RYFQOXKTJNEOPK-UHFFFAOYSA-N 0.000 claims 1
JNDQQCDFSDKSER-UHFFFAOYSA-N 6-[4-[3-butylsulfinyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCCC)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JNDQQCDFSDKSER-UHFFFAOYSA-N 0.000 claims 1
ZASUIYKFNDQMIA-UHFFFAOYSA-N 6-[4-[3-butylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCCC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ZASUIYKFNDQMIA-UHFFFAOYSA-N 0.000 claims 1
KFTIAZGCHCTMOT-UHFFFAOYSA-N 6-[4-[3-butylsulfonyl-5-(trifluoromethyl)phenyl]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCCC)=CC(C=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KFTIAZGCHCTMOT-UHFFFAOYSA-N 0.000 claims 1
IEGWYPHAEBHCIV-UHFFFAOYSA-N 6-[4-[3-butylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCCC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 IEGWYPHAEBHCIV-UHFFFAOYSA-N 0.000 claims 1
SSONLEKJEGAVTJ-UHFFFAOYSA-N 6-[4-[3-chloro-4-(trifluoromethyl)phenyl]furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(Cl)C(=CC=2)C(F)(F)F)=CO1 SSONLEKJEGAVTJ-UHFFFAOYSA-N 0.000 claims 1
UWTOIYQHKDNZJO-UHFFFAOYSA-N 6-[4-[3-chloro-4-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC(C=2C=C(Cl)C(=CC=2)C(F)(F)F)=CS1 UWTOIYQHKDNZJO-UHFFFAOYSA-N 0.000 claims 1
OOTZUIKEEJVCSV-UHFFFAOYSA-N 6-[4-[3-cyano-4-(trifluoromethyl)phenoxy]phenyl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(C(F)(F)F)C(C#N)=C1 OOTZUIKEEJVCSV-UHFFFAOYSA-N 0.000 claims 1
NWXKKBYYKUTRQS-UHFFFAOYSA-N 6-[4-[4-(dimethylamino)phenoxy]-3-methylphenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=CC(N(C)C)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C NWXKKBYYKUTRQS-UHFFFAOYSA-N 0.000 claims 1
LUOOSMFFSMOUDJ-UHFFFAOYSA-N 6-[5-(1,3-benzodioxol-5-yl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3OCOC3=CC=2)O1 LUOOSMFFSMOUDJ-UHFFFAOYSA-N 0.000 claims 1
ZDSGEESPGYWITI-UHFFFAOYSA-N 6-[5-(1,3-benzodioxol-5-yl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3OCOC3=CC=2)S1 ZDSGEESPGYWITI-UHFFFAOYSA-N 0.000 claims 1
UMRSJVZAGKXZTA-UHFFFAOYSA-N 6-[5-(2-bromophenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C(=CC=CC=2)Br)S1 UMRSJVZAGKXZTA-UHFFFAOYSA-N 0.000 claims 1
ZEYTUIVYNYOENU-UHFFFAOYSA-N 6-[5-(2-chloropyridin-4-yl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(Cl)N=CC=2)S1 ZEYTUIVYNYOENU-UHFFFAOYSA-N 0.000 claims 1
NLXONJSMFVRZGC-UHFFFAOYSA-N 6-[5-(3,5-dichlorophenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(Cl)C=C(Cl)C=2)S1 NLXONJSMFVRZGC-UHFFFAOYSA-N 0.000 claims 1
PWDHLODDXBXDNP-UHFFFAOYSA-N 6-[5-(3-amino-4-ethoxyphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(N)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 PWDHLODDXBXDNP-UHFFFAOYSA-N 0.000 claims 1
MOABLPWRLMZKDS-UHFFFAOYSA-N 6-[5-(3-chloro-4-cyanophenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(Cl)C(C#N)=CC=2)S1 MOABLPWRLMZKDS-UHFFFAOYSA-N 0.000 claims 1
KUHOSULDHAJJKS-UHFFFAOYSA-N 6-[5-(3-chloro-4-ethoxyphenyl)thiophen-2-yl]-1-[(2,4-dichlorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)S1 KUHOSULDHAJJKS-UHFFFAOYSA-N 0.000 claims 1
WTNIRRFZHPBWNO-UHFFFAOYSA-N 6-[5-(3-chloro-4-ethoxyphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 WTNIRRFZHPBWNO-UHFFFAOYSA-N 0.000 claims 1
LYDAIXIHKYCBRJ-UHFFFAOYSA-N 6-[5-(3-chloro-4-hydroxyphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(O)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 LYDAIXIHKYCBRJ-UHFFFAOYSA-N 0.000 claims 1
FFGMPGXDAMZRHG-UHFFFAOYSA-N 6-[5-(3-chloro-4-methylphenyl)furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 FFGMPGXDAMZRHG-UHFFFAOYSA-N 0.000 claims 1
KHHQQPRDNRSQDO-UHFFFAOYSA-N 6-[5-(3-chloro-4-methylphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(C)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 KHHQQPRDNRSQDO-UHFFFAOYSA-N 0.000 claims 1
LAPXBYWWPHEUQH-UHFFFAOYSA-N 6-[5-(3-cyano-4-ethoxyphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C#N)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 LAPXBYWWPHEUQH-UHFFFAOYSA-N 0.000 claims 1
SFQFUULWCVZUFP-UHFFFAOYSA-N 6-[5-(3-ethylsulfonyl-5-propan-2-ylphenyl)thiophen-2-yl]-1-[(2-fluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 SFQFUULWCVZUFP-UHFFFAOYSA-N 0.000 claims 1
NBONFKWZDJBAAO-UHFFFAOYSA-N 6-[5-(3-ethylsulfonylphenyl)thiophen-2-yl]-1-[(2-fluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 NBONFKWZDJBAAO-UHFFFAOYSA-N 0.000 claims 1
CNHTWGGKTDKSIW-UHFFFAOYSA-N 6-[5-(3-tert-butyl-5-methylsulfonylphenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(C(C)(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CNHTWGGKTDKSIW-UHFFFAOYSA-N 0.000 claims 1
PQTOZARSJVCPKA-UHFFFAOYSA-N 6-[5-(3h-benzimidazol-5-yl)thiophen-2-yl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C3N=CNC3=CC=2)S1 PQTOZARSJVCPKA-UHFFFAOYSA-N 0.000 claims 1
FCKGWCKIJWOBTM-UHFFFAOYSA-N 6-[5-(4-amino-3-chlorophenyl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(Cl)C(N)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 FCKGWCKIJWOBTM-UHFFFAOYSA-N 0.000 claims 1
FSHGXRZKPSYKKE-UHFFFAOYSA-N 6-[5-(5-cyano-6-ethoxypyridin-3-yl)thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound C1=C(C#N)C(OCC)=NC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 FSHGXRZKPSYKKE-UHFFFAOYSA-N 0.000 claims 1
JBIHKXSLYXFONJ-UHFFFAOYSA-N 6-[5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C(=CC=C(C=2)C(F)(F)F)Cl)O1 JBIHKXSLYXFONJ-UHFFFAOYSA-N 0.000 claims 1
OKOSIOPABUPBMJ-UHFFFAOYSA-N 6-[5-[3,5-bis(methylsulfonyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CS(=O)(=O)C1=CC(S(=O)(=O)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OKOSIOPABUPBMJ-UHFFFAOYSA-N 0.000 claims 1
CFKPPVMNRZYDDW-UHFFFAOYSA-N 6-[5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)O1 CFKPPVMNRZYDDW-UHFFFAOYSA-N 0.000 claims 1
DZDWHEWSWVJWPG-UHFFFAOYSA-N 6-[5-[3,5-bis(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-dichlorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(Cl)=CC=2)Cl)=C1 DZDWHEWSWVJWPG-UHFFFAOYSA-N 0.000 claims 1
IVYPZBQWPRGDDF-UHFFFAOYSA-N 6-[5-[3-(cyclopropylmethylsulfinyl)-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)S(=O)CC2CC2)C(F)(F)F)S1 IVYPZBQWPRGDDF-UHFFFAOYSA-N 0.000 claims 1
YGHSOLXPSFAZBE-UHFFFAOYSA-N 6-[5-[3-(cyclopropylmethylsulfonyl)-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC2CC2)S1 YGHSOLXPSFAZBE-UHFFFAOYSA-N 0.000 claims 1
SWLPCCOUJWINKY-UHFFFAOYSA-N 6-[5-[3-benzylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)S(=O)CC=2C=CC=CC=2)C(F)(F)F)S1 SWLPCCOUJWINKY-UHFFFAOYSA-N 0.000 claims 1
DTUWLSCPESFKFB-UHFFFAOYSA-N 6-[5-[3-benzylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(C=C(C=2)C(F)(F)F)S(=O)(=O)CC=2C=CC=CC=2)S1 DTUWLSCPESFKFB-UHFFFAOYSA-N 0.000 claims 1
JHOPYDACRJIINS-UHFFFAOYSA-N 6-[5-[3-butylsulfinyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)CCCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JHOPYDACRJIINS-UHFFFAOYSA-N 0.000 claims 1
QPSZRNJVLYGVIV-UHFFFAOYSA-N 6-[5-[3-butylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CCCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QPSZRNJVLYGVIV-UHFFFAOYSA-N 0.000 claims 1
WJQMXNFPHLHWII-UHFFFAOYSA-N 6-[5-[3-chloro-4-(2,2,2-trifluoroethoxy)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(Cl)C(OCC(F)(F)F)=CC=2)S1 WJQMXNFPHLHWII-UHFFFAOYSA-N 0.000 claims 1
DEEQGVVVFMATIF-UHFFFAOYSA-N 6-[5-[3-chloro-4-(trifluoromethyl)phenyl]furan-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(Cl)C(=CC=2)C(F)(F)F)O1 DEEQGVVVFMATIF-UHFFFAOYSA-N 0.000 claims 1
RWWMLBLSMDUOJQ-UHFFFAOYSA-N 6-[5-[3-chloro-4-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2,4-difluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC1=CC(F)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=C(C=2C=C(Cl)C(=CC=2)C(F)(F)F)S1 RWWMLBLSMDUOJQ-UHFFFAOYSA-N 0.000 claims 1
VDRVXHKPYRQNRD-UHFFFAOYSA-N 6-[5-[3-ethylsulfonyl-5-(trifluoromethyl)phenyl]thiophen-2-yl]-1-[(2-fluorophenyl)methyl]-2-oxo-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound FC(F)(F)C1=CC(S(=O)(=O)CC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC=CC=2)F)=C1 VDRVXHKPYRQNRD-UHFFFAOYSA-N 0.000 claims 1
ROYJZBOVDGUPEJ-UHFFFAOYSA-N 6-[6-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]pyridin-2-yl]-1h-indole-2-carboxylic acid Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C1=CC=CC(C=2C=C3NC(=CC3=CC=2)C(O)=O)=N1 ROYJZBOVDGUPEJ-UHFFFAOYSA-N 0.000 claims 1
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 1
102000013010 Member 1 Subfamily G ATP Binding Cassette Transporter Human genes 0.000 claims 1
108010090314 Member 1 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 claims 1
UTCGZMJKBHGDMD-UHFFFAOYSA-N [4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]urea Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(N)=O)C=C1 UTCGZMJKBHGDMD-UHFFFAOYSA-N 0.000 claims 1
125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 1
UKXLEADKFWSETK-UHFFFAOYSA-N benzyl 2-[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenoxy]acetate Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(OCC(=O)OCC=2C=CC=CC=2)=C1 UKXLEADKFWSETK-UHFFFAOYSA-N 0.000 claims 1
QHDHURQLDFDQTM-UHFFFAOYSA-N benzyl 2-[4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenoxy]acetate Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC(C=C1)=CC=C1OCC(=O)OCC1=CC=CC=C1 QHDHURQLDFDQTM-UHFFFAOYSA-N 0.000 claims 1
239000003613 bile acid Substances 0.000 claims 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
150000002148 esters Chemical class 0.000 claims 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 claims 1
125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims 1
MWMOJMKXHOQMHE-UHFFFAOYSA-N ethyl 2-[2-chloro-4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenoxy]acetate Chemical compound C1=C(Cl)C(OCC(=O)OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 MWMOJMKXHOQMHE-UHFFFAOYSA-N 0.000 claims 1
GTEZKBVVNMXEKQ-UHFFFAOYSA-N ethyl 5-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-1h-indole-2-carboxylate Chemical compound C=1C=C2NC(C(=O)OCC)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(F)C=C1F GTEZKBVVNMXEKQ-UHFFFAOYSA-N 0.000 claims 1
GXVIXHVLHIXPRY-UHFFFAOYSA-N ethyl 5-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-1h-indole-2-carboxylate Chemical compound C=1C=C2NC(C(=O)OCC)=CC2=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C GXVIXHVLHIXPRY-UHFFFAOYSA-N 0.000 claims 1
CDYMGJMNHFGNSW-UHFFFAOYSA-N ethyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-2-yl]-2-ethoxypyridine-3-carboxylate Chemical compound N1=C(OCC)C(C(=O)OCC)=CC(C=2OC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CDYMGJMNHFGNSW-UHFFFAOYSA-N 0.000 claims 1
ICGYRALPJLCEIC-UHFFFAOYSA-N ethyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-2-ethoxypyridine-3-carboxylate Chemical compound N1=C(OCC)C(C(=O)OCC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ICGYRALPJLCEIC-UHFFFAOYSA-N 0.000 claims 1
UUFNOVQGWQTOEW-UHFFFAOYSA-N ethyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-2-ethoxypyridine-3-carboxylate Chemical compound N1=C(OCC)C(C(=O)OCC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UUFNOVQGWQTOEW-UHFFFAOYSA-N 0.000 claims 1
125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
238000000338 in vitro Methods 0.000 claims 1
230000004060 metabolic process Effects 0.000 claims 1
238000000034 method Methods 0.000 claims 1
DZBYEIQMQHQZGJ-UUWRZZSWSA-N methyl (2r)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-2-phenylacetate Chemical compound N([C@@H](C(=O)OC)C=1C=CC=CC=1)C(=O)C(C=1)=CC=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C DZBYEIQMQHQZGJ-UUWRZZSWSA-N 0.000 claims 1
ZEAGQMFIGAYMHQ-WJOKGBTCSA-N methyl (2r)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-3-(1h-imidazol-5-yl)propanoate Chemical compound C([C@H](C(=O)OC)NC(=O)C=1C=C(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=CC=1)C1=CNC=N1 ZEAGQMFIGAYMHQ-WJOKGBTCSA-N 0.000 claims 1
CTRAOTAAHVTWGT-WJOKGBTCSA-N methyl (2r)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-3-methylbutanoate Chemical compound COC(=O)[C@@H](C(C)C)NC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 CTRAOTAAHVTWGT-WJOKGBTCSA-N 0.000 claims 1
IGEOCFNKXSUPSP-UUWRZZSWSA-N methyl (2r)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-3-phenylpropanoate Chemical compound C([C@H](C(=O)OC)NC(=O)C=1C=C(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=CC=1)C1=CC=CC=C1 IGEOCFNKXSUPSP-UUWRZZSWSA-N 0.000 claims 1
IXDDYQBHQCHKSL-WJOKGBTCSA-N methyl (2r)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-4-methylpentanoate Chemical compound COC(=O)[C@@H](CC(C)C)NC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 IXDDYQBHQCHKSL-WJOKGBTCSA-N 0.000 claims 1
JLTQHCSGKGOBGS-OAQYLSRUSA-N methyl (2r)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]propanoate Chemical compound COC(=O)[C@@H](C)NC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 JLTQHCSGKGOBGS-OAQYLSRUSA-N 0.000 claims 1
DZBYEIQMQHQZGJ-UMSFTDKQSA-N methyl (2s)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-2-phenylacetate Chemical compound N([C@H](C(=O)OC)C=1C=CC=CC=1)C(=O)C(C=1)=CC=CC=1OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=C(C#N)C(=O)N1CC1=CC=C(C)C=C1C DZBYEIQMQHQZGJ-UMSFTDKQSA-N 0.000 claims 1
ZEAGQMFIGAYMHQ-HKBQPEDESA-N methyl (2s)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-3-(1h-imidazol-5-yl)propanoate Chemical compound C([C@@H](C(=O)OC)NC(=O)C=1C=C(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=CC=1)C1=CNC=N1 ZEAGQMFIGAYMHQ-HKBQPEDESA-N 0.000 claims 1
CTRAOTAAHVTWGT-HKBQPEDESA-N methyl (2s)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-3-methylbutanoate Chemical compound COC(=O)[C@H](C(C)C)NC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 CTRAOTAAHVTWGT-HKBQPEDESA-N 0.000 claims 1
IGEOCFNKXSUPSP-UMSFTDKQSA-N methyl (2s)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-3-phenylpropanoate Chemical compound C([C@@H](C(=O)OC)NC(=O)C=1C=C(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=CC=1)C1=CC=CC=C1 IGEOCFNKXSUPSP-UMSFTDKQSA-N 0.000 claims 1
IXDDYQBHQCHKSL-HKBQPEDESA-N methyl (2s)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]-4-methylpentanoate Chemical compound COC(=O)[C@H](CC(C)C)NC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 IXDDYQBHQCHKSL-HKBQPEDESA-N 0.000 claims 1
JLTQHCSGKGOBGS-NRFANRHFSA-N methyl (2s)-2-[[3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzoyl]amino]propanoate Chemical compound COC(=O)[C@H](C)NC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=C1 JLTQHCSGKGOBGS-NRFANRHFSA-N 0.000 claims 1
OZLGLALXNWCHKA-UHFFFAOYSA-N methyl 2-[2-chloro-4-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]phenyl]acetate Chemical compound C1=C(Cl)C(CC(=O)OC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OZLGLALXNWCHKA-UHFFFAOYSA-N 0.000 claims 1
YEDISTJLMZOMTB-UHFFFAOYSA-N methyl 2-[2-chloro-4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]acetate Chemical compound C1=C(Cl)C(CC(=O)OC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YEDISTJLMZOMTB-UHFFFAOYSA-N 0.000 claims 1
XBLFXVXTBQGSAQ-UHFFFAOYSA-N methyl 2-[2-chloro-4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]acetate Chemical compound C1=C(Cl)C(CC(=O)OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 XBLFXVXTBQGSAQ-UHFFFAOYSA-N 0.000 claims 1
PJBXFWMOUNDXNQ-UHFFFAOYSA-N methyl 2-[2-chloro-4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]acetate Chemical compound C1=C(Cl)C(CC(=O)OC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 PJBXFWMOUNDXNQ-UHFFFAOYSA-N 0.000 claims 1
AJRJPBHIQOFJJN-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-4-fluorophenyl]acetate Chemical compound COC(=O)CC1=CC=C(F)C(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 AJRJPBHIQOFJJN-UHFFFAOYSA-N 0.000 claims 1
VWZOADABTAHMRW-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-4-methoxyphenyl]acetate Chemical compound COC(=O)CC1=CC=C(OC)C(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VWZOADABTAHMRW-UHFFFAOYSA-N 0.000 claims 1
SJSMAEBRPCYTJC-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]-2-methylpropanoate Chemical compound COC(=O)C(C)(C)C1=CC=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 SJSMAEBRPCYTJC-UHFFFAOYSA-N 0.000 claims 1
KFASMUJJXLXQQQ-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]acetate Chemical compound COC(=O)CC1=CC=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KFASMUJJXLXQQQ-UHFFFAOYSA-N 0.000 claims 1
HHUNVRJRZBDLTQ-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-4-fluorophenyl]acetate Chemical compound COC(=O)CC1=CC=C(F)C(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HHUNVRJRZBDLTQ-UHFFFAOYSA-N 0.000 claims 1
URCHMVBOUCXHGU-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-4-methoxyphenyl]acetate Chemical compound COC(=O)CC1=CC=C(OC)C(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 URCHMVBOUCXHGU-UHFFFAOYSA-N 0.000 claims 1
DYKSKDSKAVEUIV-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]-2-methylpropanoate Chemical compound COC(=O)C(C)(C)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 DYKSKDSKAVEUIV-UHFFFAOYSA-N 0.000 claims 1
YNCONRHYYCGKNU-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]acetate Chemical compound COC(=O)CC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YNCONRHYYCGKNU-UHFFFAOYSA-N 0.000 claims 1
FBZIXAYIDFZGEW-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-4-fluorophenyl]acetate Chemical compound COC(=O)CC1=CC=C(F)C(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FBZIXAYIDFZGEW-UHFFFAOYSA-N 0.000 claims 1
NILRMHLPOAARAF-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-5-propan-2-yloxyphenyl]acetate Chemical compound COC(=O)CC1=CC(OC(C)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NILRMHLPOAARAF-UHFFFAOYSA-N 0.000 claims 1
ZOOKZDQESMFQQN-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]-2-methylpropanoate Chemical compound COC(=O)C(C)(C)C1=CC=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ZOOKZDQESMFQQN-UHFFFAOYSA-N 0.000 claims 1
CPSAHTKGRGQEMH-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]acetate Chemical compound COC(=O)CC1=CC=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CPSAHTKGRGQEMH-UHFFFAOYSA-N 0.000 claims 1
AXVPDVXKOMGWQR-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-4-(1,1-difluoro-3-methylbutyl)-1-[(2,4-difluorophenyl)methyl]-6-oxopyridin-2-yl]thiophen-2-yl]phenyl]acetate Chemical compound COC(=O)CC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)CC(C)C)CC=2C(=CC(F)=CC=2)F)=C1 AXVPDVXKOMGWQR-UHFFFAOYSA-N 0.000 claims 1
VCWMCOHAKYJPEL-UHFFFAOYSA-N methyl 2-[3-[5-[5-cyano-4-(1,1-difluoroheptyl)-1-[(2,4-difluorophenyl)methyl]-6-oxopyridin-2-yl]thiophen-2-yl]phenyl]acetate Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(C#N)=C(C(F)(F)CCCCCC)C=C1C(S1)=CC=C1C1=CC=CC(CC(=O)OC)=C1 VCWMCOHAKYJPEL-UHFFFAOYSA-N 0.000 claims 1
YXYSOQOQVBOGJX-UHFFFAOYSA-N methyl 2-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]acetate Chemical compound C1=CC(CC(=O)OC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YXYSOQOQVBOGJX-UHFFFAOYSA-N 0.000 claims 1
OPDIXZGEKVFMMA-UHFFFAOYSA-N methyl 2-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]acetate Chemical compound C1=CC(CC(=O)OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 OPDIXZGEKVFMMA-UHFFFAOYSA-N 0.000 claims 1
SYPAPJXDCDLXBH-UHFFFAOYSA-N methyl 2-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]acetate Chemical compound C1=CC(CC(=O)OC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 SYPAPJXDCDLXBH-UHFFFAOYSA-N 0.000 claims 1
ICKBNCQLOLNCQJ-UHFFFAOYSA-N methyl 2-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-2-methoxyphenyl]acetate Chemical compound C1=C(OC)C(CC(=O)OC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ICKBNCQLOLNCQJ-UHFFFAOYSA-N 0.000 claims 1
YYVOZDWXWKRLSN-UHFFFAOYSA-N methyl 2-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-2-methoxyphenyl]acetate Chemical compound C1=C(OC)C(CC(=O)OC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 YYVOZDWXWKRLSN-UHFFFAOYSA-N 0.000 claims 1
CFJHGKBPMFFUCV-UHFFFAOYSA-N methyl 2-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-2-methoxyphenyl]acetate Chemical compound C1=C(OC)C(CC(=O)OC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CFJHGKBPMFFUCV-UHFFFAOYSA-N 0.000 claims 1
ZLGYFEUZNSYVRL-UHFFFAOYSA-N methyl 3-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]propanoate Chemical compound COC(=O)CCC1=CC=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 ZLGYFEUZNSYVRL-UHFFFAOYSA-N 0.000 claims 1
CEXOKLJXDNIRSX-UHFFFAOYSA-N methyl 3-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]propanoate Chemical compound COC(=O)CCC1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 CEXOKLJXDNIRSX-UHFFFAOYSA-N 0.000 claims 1
NMOHDTKOPHDVEH-UHFFFAOYSA-N methyl 3-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]phenyl]propanoate Chemical compound C1=CC(CCC(=O)OC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 NMOHDTKOPHDVEH-UHFFFAOYSA-N 0.000 claims 1
KXILSWNIWBYIFX-UHFFFAOYSA-N methyl 3-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]phenyl]propanoate Chemical compound C1=CC(CCC(=O)OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 KXILSWNIWBYIFX-UHFFFAOYSA-N 0.000 claims 1
WJPDQKATWBSVDM-UHFFFAOYSA-N methyl 3-[4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]propanoate Chemical compound C1=CC(CCC(=O)OC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 WJPDQKATWBSVDM-UHFFFAOYSA-N 0.000 claims 1
LDIKAEICMDKVQV-UHFFFAOYSA-N methyl 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]-2-methylphenoxy]benzoate Chemical compound COC(=O)C1=CC=CC(OC=2C(=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C)=C1 LDIKAEICMDKVQV-UHFFFAOYSA-N 0.000 claims 1
NKHUZPALYUEMCC-UHFFFAOYSA-N methyl 3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-5-phenylmethoxybenzoate Chemical compound C=1C(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)=CC(C(=O)OC)=CC=1OCC1=CC=CC=C1 NKHUZPALYUEMCC-UHFFFAOYSA-N 0.000 claims 1
HGCSHAIQMFDQHN-UHFFFAOYSA-N methyl 3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-5-propan-2-ylbenzoate Chemical compound COC(=O)C1=CC(C(C)C)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 HGCSHAIQMFDQHN-UHFFFAOYSA-N 0.000 claims 1
UGNVNHBZZUSZKQ-UHFFFAOYSA-N methyl 3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-5-propan-2-ylbenzoate Chemical compound COC(=O)C1=CC(C(C)C)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UGNVNHBZZUSZKQ-UHFFFAOYSA-N 0.000 claims 1
VQQLIAFYDGYWTE-UHFFFAOYSA-N methyl 3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VQQLIAFYDGYWTE-UHFFFAOYSA-N 0.000 claims 1
QTFKQSUGUNVYTC-UHFFFAOYSA-N methyl 3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-5-propan-2-ylbenzoate Chemical compound COC(=O)C1=CC(C(C)C)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QTFKQSUGUNVYTC-UHFFFAOYSA-N 0.000 claims 1
GMDSUTHWJVOFCU-UHFFFAOYSA-N methyl 4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]-2-methylphenoxy]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(C)=CC=2)C)C=C1C GMDSUTHWJVOFCU-UHFFFAOYSA-N 0.000 claims 1
UCNYNTWTUPIORE-UHFFFAOYSA-N methyl 4-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 UCNYNTWTUPIORE-UHFFFAOYSA-N 0.000 claims 1
KWNCTZQAFONNFO-UHFFFAOYSA-N methyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-2-methylsulfonylpyridine-3-carboxylate Chemical compound N1=C(S(C)(=O)=O)C(C(=O)OC)=CC(C=2C=C(OC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 KWNCTZQAFONNFO-UHFFFAOYSA-N 0.000 claims 1
VXGYROOBCKCCCX-UHFFFAOYSA-N methyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-2-methylsulfanylpyridine-3-carboxylate Chemical compound N1=C(SC)C(C(=O)OC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VXGYROOBCKCCCX-UHFFFAOYSA-N 0.000 claims 1
LCWQEVVOWSXIGE-UHFFFAOYSA-N methyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-2-methylsulfonylpyridine-3-carboxylate Chemical compound N1=C(S(C)(=O)=O)C(C(=O)OC)=CC(C=2SC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 LCWQEVVOWSXIGE-UHFFFAOYSA-N 0.000 claims 1
QGEMDUFZBBPOLE-UHFFFAOYSA-N methyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-2-methylsulfanylpyridine-3-carboxylate Chemical compound N1=C(SC)C(C(=O)OC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 QGEMDUFZBBPOLE-UHFFFAOYSA-N 0.000 claims 1
OLHAJFZRMWKJJP-UHFFFAOYSA-N methyl 5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-2-methylsulfonylpyridine-3-carboxylate Chemical compound N1=C(S(C)(=O)=O)C(C(=O)OC)=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OLHAJFZRMWKJJP-UHFFFAOYSA-N 0.000 claims 1
MPVCXMARJCJZEK-UHFFFAOYSA-N methyl 6-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]-4-(trifluoromethyl)pyridine-3-carboxylate Chemical compound C1=C(C(F)(F)F)C(C(=O)OC)=CN=C1OC1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 MPVCXMARJCJZEK-UHFFFAOYSA-N 0.000 claims 1
CDLIDSYGVMWBFG-UHFFFAOYSA-N n'-[4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]oxamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NC(=O)C(N)=O)C=C1 CDLIDSYGVMWBFG-UHFFFAOYSA-N 0.000 claims 1
KNAGTJPJXOIECF-UHFFFAOYSA-N n-[4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]phenyl]methanesulfonamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=C(NS(C)(=O)=O)C=C1 KNAGTJPJXOIECF-UHFFFAOYSA-N 0.000 claims 1
YEGHETGJUPHJTK-UHFFFAOYSA-N n-[[1-[(2,4-difluorophenyl)methyl]-6-[5-(4-methylsulfonylphenyl)thiophen-2-yl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]methyl]methanesulfonamide Chemical compound C=1C=C(F)C=C(F)C=1CN1C(=O)C(CNS(=O)(=O)C)=C(C(F)(F)F)C=C1C(S1)=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 YEGHETGJUPHJTK-UHFFFAOYSA-N 0.000 claims 1
UXMZIGQMGVBELN-UHFFFAOYSA-N n-benzyl-3-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzamide Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1=CC=CC(C(=O)NCC=2C=CC=CC=2)=C1 UXMZIGQMGVBELN-UHFFFAOYSA-N 0.000 claims 1
UYNWNEFCARQEEQ-UHFFFAOYSA-N n-tert-butyl-3-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]benzamide Chemical compound CC(C)(C)NC(=O)C1=CC=CC(OC=2C=CC(=CC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 UYNWNEFCARQEEQ-UHFFFAOYSA-N 0.000 claims 1
125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
125000005545 phthalimidyl group Chemical group 0.000 claims 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
FKRCODPIKNYEAC-UHFFFAOYSA-N propionic acid ethyl ester Natural products CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 claims 1
125000003373 pyrazinyl group Chemical group 0.000 claims 1
125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
230000001105 regulatory effect Effects 0.000 claims 1
JRTSEWBBPGPFGC-UHFFFAOYSA-N tert-butyl 2-[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]acetate Chemical compound CC(C)(C)OC(=O)CC1=CC=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 JRTSEWBBPGPFGC-UHFFFAOYSA-N 0.000 claims 1
VEGROOFOOBSEPY-UHFFFAOYSA-N tert-butyl 4-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 VEGROOFOOBSEPY-UHFFFAOYSA-N 0.000 claims 1
BKPVYTOVKQEKJL-UHFFFAOYSA-N tert-butyl 4-[4-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)C=C1 BKPVYTOVKQEKJL-UHFFFAOYSA-N 0.000 claims 1
GQYIVQKCWUFGJA-UHFFFAOYSA-N tert-butyl 4-[4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenoxy]piperidine-1-carboxylate Chemical compound CC1=CC(C)=CC=C1CN1C(=O)C(C#N)=C(C(F)(F)F)C=C1C(C=C1)=CC=C1OC1CCN(C(=O)OC(C)(C)C)CC1 GQYIVQKCWUFGJA-UHFFFAOYSA-N 0.000 claims 1
XKXIQBVKMABYQJ-UHFFFAOYSA-N tert-butyl hydrogen carbonate Chemical compound CC(C)(C)OC(O)=O XKXIQBVKMABYQJ-UHFFFAOYSA-N 0.000 claims 1
AEQRHLABUZOKMO-UHFFFAOYSA-N tert-butyl n-[5-[3-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]phenyl]-2-ethoxyphenyl]carbamate Chemical compound C1=C(NC(=O)OC(C)(C)C)C(OCC)=CC=C1C1=CC=CC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 AEQRHLABUZOKMO-UHFFFAOYSA-N 0.000 claims 1
FHHPXESTYFMUPV-UHFFFAOYSA-N tert-butyl n-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-2-yl]-2-ethoxyphenyl]carbamate Chemical compound C1=C(NC(=O)OC(C)(C)C)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)O1 FHHPXESTYFMUPV-UHFFFAOYSA-N 0.000 claims 1
MMRVDAMQPVMQSA-UHFFFAOYSA-N tert-butyl n-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]furan-3-yl]-2-ethoxyphenyl]carbamate Chemical compound C1=C(NC(=O)OC(C)(C)C)C(OCC)=CC=C1C1=COC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 MMRVDAMQPVMQSA-UHFFFAOYSA-N 0.000 claims 1
LKZGJGWWTUCGQR-UHFFFAOYSA-N tert-butyl n-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-2-yl]-2-ethoxyphenyl]carbamate Chemical compound C1=C(NC(=O)OC(C)(C)C)C(OCC)=CC=C1C1=CC=C(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)S1 LKZGJGWWTUCGQR-UHFFFAOYSA-N 0.000 claims 1
OCAKUBUIPAUCGA-UHFFFAOYSA-N tert-butyl n-[5-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]-2-ethoxyphenyl]carbamate Chemical compound C1=C(NC(=O)OC(C)(C)C)C(OCC)=CC=C1C1=CSC(C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 OCAKUBUIPAUCGA-UHFFFAOYSA-N 0.000 claims 1
FXXZEBNCIMQDMY-UHFFFAOYSA-N tert-butyl n-[[3-[5-[5-cyano-1-[(2,4-difluorophenyl)methyl]-6-oxo-4-(trifluoromethyl)pyridin-2-yl]thiophen-3-yl]phenyl]methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1=CC=CC(C=2C=C(SC=2)C=2N(C(=O)C(C#N)=C(C=2)C(F)(F)F)CC=2C(=CC(F)=CC=2)F)=C1 FXXZEBNCIMQDMY-UHFFFAOYSA-N 0.000 claims 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1

JP2007522845A 2004-07-24 2005-07-24 核レセプターのモジュレーター Expired - Fee Related JP5017607B2 (ja)