AU2005280487A1 - Modulators of nuclear receptors - Google Patents

Modulators of nuclear receptors Download PDF

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Publication number
AU2005280487A1
AU2005280487A1 AU2005280487A AU2005280487A AU2005280487A1 AU 2005280487 A1 AU2005280487 A1 AU 2005280487A1 AU 2005280487 A AU2005280487 A AU 2005280487A AU 2005280487 A AU2005280487 A AU 2005280487A AU 2005280487 A1 AU2005280487 A1 AU 2005280487A1
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AU
Australia
Prior art keywords
oxo
trifluoromethyl
benzyl
optionally substituted
phenyl
Prior art date
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Abandoned
Application number
AU2005280487A
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English (en)
Inventor
Lynne Canne Bannen
Christopher D. Bayne
Diva Sze-Ming Chan
Ping Huang
Vasu Jammalamadaka
Alan T. Johnson
Richard G. Khoury
Shao-Po Lu
Morrison B. Mac
Raju Mohan
Michael C. Nyman
Jason Jevious Parks
Edwin J. Schweiger
William C. Stevens, Jr.
Haixia Wang
Yong Wang
Yinong Xie
Wei Xu
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Exelixis Inc
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Exelixis Inc
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Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of AU2005280487A1 publication Critical patent/AU2005280487A1/en
Abandoned legal-status Critical Current

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2005280487A 2004-07-24 2005-07-24 Modulators of nuclear receptors Abandoned AU2005280487A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/899,458 2004-07-24
US10/899,458 US7482366B2 (en) 2001-12-21 2004-07-24 Modulators of LXR
PCT/US2005/026353 WO2006025979A2 (en) 2004-07-24 2005-07-24 Modulators of nuclear receptors

Publications (1)

Publication Number Publication Date
AU2005280487A1 true AU2005280487A1 (en) 2006-03-09

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AU2005280487A Abandoned AU2005280487A1 (en) 2004-07-24 2005-07-24 Modulators of nuclear receptors

Country Status (6)

Country Link
US (3) US7482366B2 (OSRAM)
EP (1) EP1773337A4 (OSRAM)
JP (1) JP5017607B2 (OSRAM)
AU (1) AU2005280487A1 (OSRAM)
CA (1) CA2571989A1 (OSRAM)
WO (1) WO2006025979A2 (OSRAM)

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ES2421511T3 (es) 2001-12-21 2013-09-03 X Ceptor Therapeutics Inc Moduladores de LXR
WO2003082198A2 (en) * 2002-03-27 2003-10-09 Smithkline Beecham Corporation Methods of treatment with lxr modulators
WO2006059778A1 (ja) * 2004-12-01 2006-06-08 Banyu Pharmaceutical Co., Ltd. 置換ピリドン誘導体
US7741317B2 (en) * 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7790745B2 (en) * 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
JP2010503730A (ja) * 2006-09-19 2010-02-04 ワイス エルエルシー 変形性関節症の治療のためのｌｘｒアゴニストの使用
WO2008036238A2 (en) * 2006-09-19 2008-03-27 Wyeth Use of lxr modulators for the prevention and treatment of skin aging
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
KR20090094125A (ko) * 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
JP2010526145A (ja) 2007-05-04 2010-07-29 ブリストル−マイヤーズ スクイブ カンパニー ［６，６］および［６，７］−二環式ｇｐｒ１１９ｇタンパク質結合受容体アゴニスト
WO2008137436A1 (en) * 2007-05-04 2008-11-13 Bristol-Myers Squibb Company [6,5]-bicyclic gpr119 g protein-coupled receptor agonists
JP5301539B2 (ja) 2007-07-17 2013-09-25 ブリストル−マイヤーズ スクイブ カンパニー Ｇｐｒ１１９ｇタンパク質共役受容体の調節方法および選択された化合物
TW200913993A (en) * 2007-08-30 2009-04-01 Takeda Pharmaceutical Substituted pyrazole derivatives
US8039493B2 (en) * 2007-09-27 2011-10-18 Hoffmann-La Roche Inc. Biaryl sulfonamide derivatives
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US8013001B2 (en) 2011-09-06
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US20080119488A1 (en) 2008-05-22
US20050080111A1 (en) 2005-04-14
US7482366B2 (en) 2009-01-27
JP5017607B2 (ja) 2012-09-05
WO2006025979A2 (en) 2006-03-09

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