BR0011753A - Composições e métodos para aumentar o efluxo de colesterol e elevar o hdl utilizando a proteìna abc1 transportadora do cassete de ligação de atp - Google Patents

Composições e métodos para aumentar o efluxo de colesterol e elevar o hdl utilizando a proteìna abc1 transportadora do cassete de ligação de atp

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Publication number
BR0011753A
BR0011753A BR0011753-6A BR0011753A BR0011753A BR 0011753 A BR0011753 A BR 0011753A BR 0011753 A BR0011753 A BR 0011753A BR 0011753 A BR0011753 A BR 0011753A
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Prior art keywords
abc1
methods
compositions
relates
polypeptides
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Application number
BR0011753-6A
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English (en)
Inventor
Richard M Lawn
David Wade
Michael Garvin
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Cv Therapeutics Inc
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Publication date
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of BR0011753A publication Critical patent/BR0011753A/pt

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    • C12N15/52Genes encoding for enzymes or proenzymes
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
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    • C12N2799/02Uses of viruses as vector
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    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

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Abstract

"COMPOSIçõES E MéTODOS PARA AUMENTAR O EFLUXO DE COLESTEROL E ELEVAR O HDL UTILIZANDO A PROTEìNA ABC1 TRANSPORTADORA DO CASSETE DE LIGAçãO DE ATP". A presente invenção refere-se a novos polipetídeos de ABC1 e moléculas de ácido nucléico codificando os mesmos. A invenção também refere-se a vetores recombinantes, células hospedeiras e composições que compreendem polinucleotídeos de ASC1, bem como a métodos para a produção de polipeptídeos de ABC1. A invenção também referre-se a anticorpos que se ligam, especificamente, aos polipeptídeos de ABCI. Além disso, a invenção refere-se a métodos para aumentar o efluxo de colesterol, bem como a métodos para aumentar a expressão e a atividade de ABC1. A presente invenção refere-se, ainda, a métodos para identificar os compostos que modulam a expressão de ABC1 e os métodos para detectar o nível comparativo de polipeptídeos de ABC1 e polinucleotídeos em um paciente mamífero. A presente invenção também proporciona conjuntos e composições adequadas para peneirar os compostos a fim de determinar a expressão de ABC1 que modula a atividade do composto, bem como conjuntos e composições adequadas para determinar se um composto modula o efluxo de colesterol dependente de ABC1.
BR0011753-6A 1999-06-18 2000-06-16 Composições e métodos para aumentar o efluxo de colesterol e elevar o hdl utilizando a proteìna abc1 transportadora do cassete de ligação de atp BR0011753A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14026499P 1999-06-18 1999-06-18
US15387299P 1999-09-14 1999-09-14
US16657399P 1999-11-19 1999-11-19
PCT/US2000/016765 WO2000078972A2 (en) 1999-06-18 2000-06-16 Regulation with binding cassette transporter protein abc1

Publications (1)

Publication Number Publication Date
BR0011753A true BR0011753A (pt) 2002-04-30

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BR0011753-6A BR0011753A (pt) 1999-06-18 2000-06-16 Composições e métodos para aumentar o efluxo de colesterol e elevar o hdl utilizando a proteìna abc1 transportadora do cassete de ligação de atp
BR0011696-3A BR0011696A (pt) 1999-06-18 2000-06-16 Composições e métodos para aumento do efluxo de colesterol e elevação de hdl usando proteìna abc1 transportadora de cassete de ligação de atp

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Country Status (19)

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EP (2) EP1190065A2 (pt)
JP (4) JP2003508031A (pt)
KR (2) KR100476519B1 (pt)
CN (2) CN1379817A (pt)
AR (2) AR024576A1 (pt)
AT (1) ATE422545T1 (pt)
AU (3) AU777461B2 (pt)
BR (2) BR0011753A (pt)
CA (2) CA2375787C (pt)
DE (1) DE60041545D1 (pt)
HK (2) HK1046427A1 (pt)
IL (2) IL147021A0 (pt)
MX (2) MXPA01013174A (pt)
NO (2) NO20016114L (pt)
NZ (3) NZ531401A (pt)
SG (2) SG121852A1 (pt)
TR (2) TR200200441T2 (pt)
TW (2) TWI304737B (pt)
WO (2) WO2000078972A2 (pt)

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IL147022A0 (en) 2002-08-14
EP1218515B1 (en) 2009-02-11
CA2375787A1 (en) 2000-12-28
CN1434865A (zh) 2003-08-06
AR024576A1 (es) 2002-10-16
BR0011696A (pt) 2002-04-30
CN1379817A (zh) 2002-11-13
WO2000078972A3 (en) 2002-05-02
NO20016114D0 (no) 2001-12-14
TWI259205B (en) 2006-08-01
HK1046708A1 (zh) 2003-01-24
CA2375787C (en) 2007-03-27
TW200626176A (en) 2006-08-01
AR024391A1 (es) 2002-10-02
SG121852A1 (en) 2006-05-26
TWI304737B (en) 2009-01-01
TR200200441T2 (tr) 2002-11-21
MXPA01013175A (es) 2002-06-04
NZ531401A (en) 2005-08-26
NZ516061A (en) 2004-04-30
ATE422545T1 (de) 2009-02-15
WO2000078971A2 (en) 2000-12-28
IL147021A0 (en) 2002-08-14
NO20016114L (no) 2002-02-12
AU2005200171A1 (en) 2005-02-10
JP2003506097A (ja) 2003-02-18
JP2005112859A (ja) 2005-04-28
DE60041545D1 (de) 2009-03-26
WO2000078972A9 (en) 2002-07-18
AU5743400A (en) 2001-01-09
KR20020012281A (ko) 2002-02-15
NO20016121D0 (no) 2001-12-14
EP1218515A2 (en) 2002-07-03
JP2003508031A (ja) 2003-03-04
EP1190065A2 (en) 2002-03-27
HK1046427A1 (zh) 2003-01-10
TR200200440T2 (tr) 2002-09-23
KR20020012612A (ko) 2002-02-16
CN100513570C (zh) 2009-07-15
AU5746700A (en) 2001-01-09
WO2000078972A2 (en) 2000-12-28
SG121853A1 (en) 2006-05-26
KR100476519B1 (ko) 2005-03-17
JP2006137750A (ja) 2006-06-01
MXPA01013174A (es) 2002-06-04
WO2000078971A3 (en) 2002-01-17
JP4277956B2 (ja) 2009-06-10
NZ529785A (en) 2005-09-30
AU777461B2 (en) 2004-10-14
NO20016121L (no) 2002-02-12
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