HK1046427A1 - 使用atp結合盒式蛋白質輸送器增加膽固醇溢出和提高hdl水平的成分與方法 - Google Patents

使用atp結合盒式蛋白質輸送器增加膽固醇溢出和提高hdl水平的成分與方法

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Publication number
HK1046427A1
HK1046427A1 HK02107131.3A HK02107131A HK1046427A1 HK 1046427 A1 HK1046427 A1 HK 1046427A1 HK 02107131 A HK02107131 A HK 02107131A HK 1046427 A1 HK1046427 A1 HK 1046427A1
Authority
HK
Hong Kong
Prior art keywords
transporter protein
atp binding
binding cassette
cassette transporter
abc1 polypeptides
Prior art date
Application number
HK02107131.3A
Other languages
English (en)
Inventor
M Lawn Richard
Wade David
F Oram John
Garvin Michael
Original Assignee
Cv Therapeutics Inc
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics Inc, Univ Washington filed Critical Cv Therapeutics Inc
Publication of HK1046427A1 publication Critical patent/HK1046427A1/zh

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
HK02107131.3A 1999-06-18 2002-09-26 使用atp結合盒式蛋白質輸送器增加膽固醇溢出和提高hdl水平的成分與方法 HK1046427A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14026499P 1999-06-18 1999-06-18
US15387299P 1999-09-14 1999-09-14
US16657399P 1999-11-19 1999-11-19
PCT/US2000/016591 WO2000078971A2 (en) 1999-06-18 2000-06-16 Atp binding cassette transporter protein abc1 popypeptides

Publications (1)

Publication Number Publication Date
HK1046427A1 true HK1046427A1 (zh) 2003-01-10

Family

ID=27385472

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02107131.3A HK1046427A1 (zh) 1999-06-18 2002-09-26 使用atp結合盒式蛋白質輸送器增加膽固醇溢出和提高hdl水平的成分與方法
HK02108234.7A HK1046708A1 (zh) 1999-06-18 2002-11-13 使用atp結合盒式蛋白質輸送器增加膽固醇溢出和提高hdl水平的成分與方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK02108234.7A HK1046708A1 (zh) 1999-06-18 2002-11-13 使用atp結合盒式蛋白質輸送器增加膽固醇溢出和提高hdl水平的成分與方法

Country Status (19)

Country Link
EP (2) EP1190065A2 (zh)
JP (4) JP2003508031A (zh)
KR (2) KR100476519B1 (zh)
CN (2) CN1379817A (zh)
AR (2) AR024576A1 (zh)
AT (1) ATE422545T1 (zh)
AU (3) AU777461B2 (zh)
BR (2) BR0011753A (zh)
CA (2) CA2375787C (zh)
DE (1) DE60041545D1 (zh)
HK (2) HK1046427A1 (zh)
IL (2) IL147021A0 (zh)
MX (2) MXPA01013174A (zh)
NO (2) NO20016114L (zh)
NZ (3) NZ531401A (zh)
SG (2) SG121852A1 (zh)
TR (2) TR200200441T2 (zh)
TW (2) TWI304737B (zh)
WO (2) WO2000078972A2 (zh)

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ATE496893T1 (de) 2002-12-20 2011-02-15 X Ceptor Therapeutics Inc Isochinolinonderivate und deren verwendung als medikamente
RU2006105646A (ru) 2003-07-23 2007-09-10 Экселиксис, Инк. (Us) Производные азепина в качестве фармацевтических агентов
WO2005116057A1 (en) * 2004-05-27 2005-12-08 Baker Medical Research Institute Monoclonal antibody against abca1
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CN101213214B (zh) 2005-05-20 2014-06-25 埃博灵克斯股份有限公司 针对冯威勒布兰特因子的单一结构域vhh抗体
AU2006261845C1 (en) 2005-06-27 2013-05-16 Exelixis Patent Company Llc Imidazole based LXR modulators
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7790745B2 (en) 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
WO2008062830A1 (fr) 2006-11-24 2008-05-29 Hykes Laboratories Llc Composé de spiroquinone et composition pharmaceutique
EP2514767A1 (en) 2006-12-19 2012-10-24 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
US20100062004A1 (en) 2006-12-19 2010-03-11 Ablynx N.V. Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
WO2009068625A2 (en) 2007-11-27 2009-06-04 Ablynx N.V. Amino acid sequences directed against her2 and polypeptides comprising the same for the treatment of cancers and/or tumors
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US8557965B2 (en) 2008-04-07 2013-10-15 Ablynx N.V. Single variable domains against notch pathway members
EP2403873A1 (en) 2009-03-05 2012-01-11 Ablynx N.V. Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof
ES2610622T3 (es) * 2009-03-31 2017-04-28 The General Hospital Corporation Regulación de microARN miR-33 en el tratamiento de trastornos relacionados con colesterol
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Also Published As

Publication number Publication date
IL147022A0 (en) 2002-08-14
EP1218515B1 (en) 2009-02-11
CA2375787A1 (en) 2000-12-28
CN1434865A (zh) 2003-08-06
AR024576A1 (es) 2002-10-16
BR0011696A (pt) 2002-04-30
CN1379817A (zh) 2002-11-13
WO2000078972A3 (en) 2002-05-02
NO20016114D0 (no) 2001-12-14
TWI259205B (en) 2006-08-01
HK1046708A1 (zh) 2003-01-24
CA2375787C (en) 2007-03-27
TW200626176A (en) 2006-08-01
AR024391A1 (es) 2002-10-02
SG121852A1 (en) 2006-05-26
TWI304737B (en) 2009-01-01
TR200200441T2 (tr) 2002-11-21
MXPA01013175A (es) 2002-06-04
NZ531401A (en) 2005-08-26
NZ516061A (en) 2004-04-30
ATE422545T1 (de) 2009-02-15
WO2000078971A2 (en) 2000-12-28
IL147021A0 (en) 2002-08-14
NO20016114L (no) 2002-02-12
AU2005200171A1 (en) 2005-02-10
JP2003506097A (ja) 2003-02-18
JP2005112859A (ja) 2005-04-28
DE60041545D1 (de) 2009-03-26
WO2000078972A9 (en) 2002-07-18
AU5743400A (en) 2001-01-09
KR20020012281A (ko) 2002-02-15
NO20016121D0 (no) 2001-12-14
EP1218515A2 (en) 2002-07-03
JP2003508031A (ja) 2003-03-04
EP1190065A2 (en) 2002-03-27
TR200200440T2 (tr) 2002-09-23
KR20020012612A (ko) 2002-02-16
CN100513570C (zh) 2009-07-15
AU5746700A (en) 2001-01-09
WO2000078972A2 (en) 2000-12-28
BR0011753A (pt) 2002-04-30
SG121853A1 (en) 2006-05-26
KR100476519B1 (ko) 2005-03-17
JP2006137750A (ja) 2006-06-01
MXPA01013174A (es) 2002-06-04
WO2000078971A3 (en) 2002-01-17
JP4277956B2 (ja) 2009-06-10
NZ529785A (en) 2005-09-30
AU777461B2 (en) 2004-10-14
NO20016121L (no) 2002-02-12
WO2000078972A8 (en) 2001-06-21
CA2375781A1 (en) 2000-12-28

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