EP1242080A4 - Dopamine transporter inhibitors and their use - Google Patents

Dopamine transporter inhibitors and their use

Info

Publication number
EP1242080A4
EP1242080A4 EP00968417A EP00968417A EP1242080A4 EP 1242080 A4 EP1242080 A4 EP 1242080A4 EP 00968417 A EP00968417 A EP 00968417A EP 00968417 A EP00968417 A EP 00968417A EP 1242080 A4 EP1242080 A4 EP 1242080A4
Authority
EP
European Patent Office
Prior art keywords
dopamine transporter
transporter inhibitors
inhibitors
dopamine
transporter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00968417A
Other languages
German (de)
French (fr)
Other versions
EP1242080A1 (en
Inventor
Shaomeng Wang
Alan Kozikowski
Sukumar Sakamuri
Istivan Enyedy
Ken Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of EP1242080A1 publication Critical patent/EP1242080A1/en
Publication of EP1242080A4 publication Critical patent/EP1242080A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
EP00968417A 1999-09-27 2000-09-27 Dopamine transporter inhibitors and their use Withdrawn EP1242080A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15579799P 1999-09-27 1999-09-27
US155797P 1999-09-27
US22658100P 2000-08-21 2000-08-21
US226581P 2000-08-21
PCT/US2000/026447 WO2001022964A1 (en) 1999-09-27 2000-09-27 Dopamine transporter inhibitors and their use

Publications (2)

Publication Number Publication Date
EP1242080A1 EP1242080A1 (en) 2002-09-25
EP1242080A4 true EP1242080A4 (en) 2003-01-22

Family

ID=26852613

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00968417A Withdrawn EP1242080A4 (en) 1999-09-27 2000-09-27 Dopamine transporter inhibitors and their use

Country Status (3)

Country Link
EP (1) EP1242080A4 (en)
CA (1) CA2389049A1 (en)
WO (1) WO2001022964A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
PL2354124T3 (en) * 2006-12-19 2013-07-31 Hoffmann La Roche Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
WO2009153178A2 (en) * 2008-06-18 2009-12-23 F. Hoffmann-La Roche Ag Aryl ketone as mri
CN107406414B (en) * 2015-01-09 2022-04-19 基因泰克公司 (piperidin-3-yl) (naphthalen-2-yl) methanone derivatives as inhibitors of histone demethylase KDM2B for the treatment of cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037078A1 (en) * 1997-02-20 1998-08-27 Novo Nordisk A/S Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489669A (en) * 1947-01-11 1949-11-29 Hoffamnn La Roche Inc Preparation of 1-alkyl-3-benzoyl-4-hydroxy-4-phenyl-piperidines
FR1552758A (en) * 1963-07-01 1969-01-10
NL124853C (en) * 1963-07-19
US3317548A (en) * 1964-10-30 1967-05-02 Rexall Drug Chemical 1-allyl-3-(substituted benzoyl)-4-(substituted phenyl)-4-hydroxypiperidines
US3408445A (en) * 1967-04-10 1968-10-29 Rexall Drug Chemical Treatment of inflammation with 1-methyl - 3 - benzoyl - 4 - hydroxy - 4-phenylpiperidine and halo derivatives thereof
DE1670583A1 (en) * 1967-11-02 1971-02-25 Degussa New piperidine derivatives
US3887568A (en) * 1973-07-12 1975-06-03 Riker Laboratories Inc Process for piperidine derivatives
US3965104A (en) * 1975-06-16 1976-06-22 G. D. Searle & Co. 1-(Substituted-aminoalkyl)-3-benzoyl-4-hydroxy-4-phenylpiperidines and related compounds
US5512584A (en) * 1991-04-16 1996-04-30 Basf Aktiengesellschaft 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
US6017933A (en) * 1998-01-30 2000-01-25 University Of Saskatchewan Technologies Inc. Mannich bases of conjugated styryl ketones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037078A1 (en) * 1997-02-20 1998-08-27 Novo Nordisk A/S Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CASY, A.F. ET AL: "Phenindamine and its Analogues and Precursors: NMR Evidence of Structure and Configuration", MAGN. RESON. CHEM., vol. 30, no. 7, 1992, pages 621 - 625, XP009000566 *
DIMMOCK, J.R. ET AL: "4-(beta-Arylvinyl)-3-(beta-arylvinylketo)-1-ethyl-4-piperidinols ans Related Compounds: A Novel Class of Cytotoxic and Anticancer Agents", J. MED. CHEM., vol. 41, 1998, pages 4012 - 4020, XP002221590 *
GARCIA-MARCH, F.J. ET AL: "Pharmacological Sudies of 1-(p-Chlorophenyl)propanol and 2-(1-Hydroxy-3-butenyl)phenol: Two New Non-narcotic Analgesics Designed by Molecular Connectivity", J. PHARM. PHARMACOL., vol. 49, 1997, pages 10 - 15, XP009000642 *
See also references of WO0122964A1 *
STENLAKE, J.B. ET AL: "Synthesis and preliminary study of some ring-substituted arylpropanonamines and their quaternary salts", EUR. J. MED. CHEM., vol. 24, 1989, pages 591 - 597, XP009000568 *

Also Published As

Publication number Publication date
EP1242080A1 (en) 2002-09-25
CA2389049A1 (en) 2001-04-05
WO2001022964A1 (en) 2001-04-05

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