UY27003A1 - Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer - Google Patents

Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer

Info

Publication number
UY27003A1
UY27003A1 UY27003A UY27003A UY27003A1 UY 27003 A1 UY27003 A1 UY 27003A1 UY 27003 A UY27003 A UY 27003A UY 27003 A UY27003 A UY 27003A UY 27003 A1 UY27003 A1 UY 27003A1
Authority
UY
Uruguay
Prior art keywords
alzheimer
disease
diagnosis
radiopharmaceutical products
radiopharmaceutical
Prior art date
Application number
UY27003A
Other languages
English (en)
Inventor
Christoph-S Hilger
Jorg Stiembach
Peter Mading
Meredith H Miller
Richard Horuk
Harald Dinter
Raju Mohan
Joseph E Hesselgesser
Bernd Johannsen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of UY27003A1 publication Critical patent/UY27003A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

Uso de productos radiofarmacéuticos en el diagnóstico de la enfermedad de Alzheimer. En particular, los productos radiofarmacéuticos de la invención tienen la capacidad para atravesar la barrera hematoencefálica y unirse al receptor CCR1 presente en el tejido del cerebro de pacientes que padecen la enfermedad de Alzheimer
UY27003A 2000-11-06 2001-10-31 Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer UY27003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24629900P 2000-11-06 2000-11-06

Publications (1)

Publication Number Publication Date
UY27003A1 true UY27003A1 (es) 2002-07-31

Family

ID=22930075

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27003A UY27003A1 (es) 2000-11-06 2001-10-31 Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer

Country Status (29)

Country Link
US (2) US6676926B2 (es)
EP (1) EP1332138B1 (es)
JP (1) JP4234425B2 (es)
KR (1) KR20030045167A (es)
CN (1) CN1473158A (es)
AR (1) AR035366A1 (es)
AT (1) ATE314354T1 (es)
AU (2) AU2002214034B2 (es)
BG (1) BG107762A (es)
BR (1) BR0115150A (es)
CA (1) CA2424598A1 (es)
DE (1) DE60116365T2 (es)
EA (1) EA006199B1 (es)
EE (1) EE200300216A (es)
HR (1) HRP20030459A2 (es)
HU (1) HUP0301710A3 (es)
IL (1) IL155191A0 (es)
JO (1) JO2207B1 (es)
MX (1) MXPA03003759A (es)
NO (1) NO20032007L (es)
NZ (1) NZ525303A (es)
PE (1) PE20020531A1 (es)
PL (1) PL361631A1 (es)
SK (1) SK287495B6 (es)
TW (1) TWI238820B (es)
UY (1) UY27003A1 (es)
WO (1) WO2002036581A1 (es)
YU (1) YU33203A (es)
ZA (1) ZA200304409B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27003A1 (es) * 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
PL370548A1 (en) 2001-10-22 2005-05-30 Pfizer Products Inc. Piperazine derivatives with ccr1 receptor antagonist activity
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
DE502004006670D1 (de) * 2003-05-07 2008-05-08 Bayer Schering Pharma Ag Vorrichtung und verfahren zum nucleophilen fluorieren
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
AU2005216949B2 (en) * 2004-02-24 2011-09-22 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
GB0409236D0 (en) * 2004-04-26 2004-05-26 Novartis Ag Organic compounds
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
KR100778888B1 (ko) * 2005-11-29 2007-11-28 재단법인서울대학교산학협력재단 베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물
AU2007292883B2 (en) 2006-09-08 2013-09-05 Rhode Island Hospital Treatment, prevention, and reversal of alcohol-induced brain disease
AU2007292874B2 (en) 2006-09-08 2013-11-21 Rhode Island Hospital Treatment, prevention, and reversal of alcohol-induced liver disease
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
JP5562036B2 (ja) * 2006-12-21 2014-07-30 ハマースミス・イメイネット・リミテッド 放射性標識方法
EP2211911A4 (en) * 2007-10-31 2012-11-14 Alseres Pharmaceuticals Inc METHOD FOR DIAGNOSIS AND MONITORING OF THE TREATMENT OF LEWY BODILY DAMAGE BY EVALUATING THE DOPAMIN TRANSPORTER MIRROR
CN102046638B (zh) 2008-03-21 2015-06-03 综合医院公司 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
EP2161256A1 (en) * 2008-09-08 2010-03-10 Atomic Energy Council - Institute of Nuclear Energy Research Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof
EP2163541A1 (en) * 2008-09-12 2010-03-17 Bayer Schering Pharma Aktiengesellschaft Piperazine derivatives for binding and imaging amyloid plaques and their use
WO2011041470A2 (en) * 2009-09-30 2011-04-07 Mallinckrodt Inc. Sustained-release opiate and opiate derivative compositions
TW201201846A (en) * 2010-02-08 2012-01-16 Bayer Schering Pharma Ag Iodo precursor for a PET imaging agent of amyloid plaques
WO2011110511A1 (en) * 2010-03-11 2011-09-15 Bayer Pharma Aktiengesellschaft Spect imaging agents of amyloid plaques
US9572787B2 (en) 2011-05-19 2017-02-21 Rhode Island Hospital Inhibition of renal fibrosis
JP6584322B2 (ja) 2013-12-27 2019-10-02 国立大学法人 東京医科歯科大学 アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法
US10137211B2 (en) * 2015-08-28 2018-11-27 Chdi Foundation, Inc. Probes for imaging Huntingtin protein

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU654013B2 (en) * 1991-03-13 1994-10-20 Regents Of The University Of Minnesota 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane
EP0524146A1 (de) 1991-07-19 1993-01-20 Ciba-Geigy Ag Aminosubstituierte Piperazinderivate
GB9413772D0 (en) 1994-07-08 1994-08-24 Wyeth John & Brother Ltd 5-HT1A ligands
US5919797A (en) * 1996-04-24 1999-07-06 Emory University Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites
WO1998002151A2 (en) 1996-07-12 1998-01-22 Leukosite, Inc. Chemokine receptor antagonists and methods of use therefor
FR2758328B1 (fr) 1997-01-15 1999-04-02 Pf Medicament Nouvelles amines aromatiques derivees d'amines cycliques utiles comme medicaments
US6207665B1 (en) * 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
AUPP278498A0 (en) * 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AUPP818099A0 (en) 1999-01-14 1999-02-11 Fujisawa Pharmaceutical Co., Ltd. New n-containing heterocyclic compounds
KR20010108394A (ko) 1999-03-26 2001-12-07 다비드 에 질레스 신규 화합물
UY27003A1 (es) * 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer

Also Published As

Publication number Publication date
EA006199B1 (ru) 2005-10-27
HUP0301710A2 (hu) 2003-11-28
WO2002036581A1 (en) 2002-05-10
JO2207B1 (en) 2004-10-07
HRP20030459A2 (en) 2005-04-30
NO20032007D0 (no) 2003-05-05
JP4234425B2 (ja) 2009-03-04
EP1332138B1 (en) 2005-12-28
ATE314354T1 (de) 2006-01-15
YU33203A (sh) 2006-05-25
SK287495B6 (sk) 2010-12-07
KR20030045167A (ko) 2003-06-09
DE60116365T2 (de) 2006-08-24
CA2424598A1 (en) 2002-05-10
BG107762A (en) 2004-03-31
US6872381B1 (en) 2005-03-29
EP1332138A1 (en) 2003-08-06
EE200300216A (et) 2003-08-15
ZA200304409B (en) 2004-09-06
IL155191A0 (en) 2003-11-23
HUP0301710A3 (en) 2007-03-28
AU1403402A (en) 2002-05-15
TWI238820B (en) 2005-09-01
US20020131932A1 (en) 2002-09-19
US6676926B2 (en) 2004-01-13
BR0115150A (pt) 2003-12-30
AU2002214034B2 (en) 2006-01-05
CN1473158A (zh) 2004-02-04
PE20020531A1 (es) 2002-06-15
NZ525303A (en) 2004-10-29
NO20032007L (no) 2003-07-02
PL361631A1 (en) 2004-10-04
MXPA03003759A (es) 2003-07-28
DE60116365D1 (de) 2006-02-02
JP2004513123A (ja) 2004-04-30
SK5472003A3 (en) 2003-10-07
EA200300507A1 (ru) 2003-12-25
AR035366A1 (es) 2004-05-12

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150414