JP2013517283A5 - - Google Patents
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- Publication number
- JP2013517283A5 JP2013517283A5 JP2012549074A JP2012549074A JP2013517283A5 JP 2013517283 A5 JP2013517283 A5 JP 2013517283A5 JP 2012549074 A JP2012549074 A JP 2012549074A JP 2012549074 A JP2012549074 A JP 2012549074A JP 2013517283 A5 JP2013517283 A5 JP 2013517283A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- methylethyl
- piperazinyl
- pyridinecarboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29513810P | 2010-01-14 | 2010-01-14 | |
| US61/295,138 | 2010-01-14 | ||
| US31700510P | 2010-03-24 | 2010-03-24 | |
| US61/317,005 | 2010-03-24 | ||
| PCT/US2011/021114 WO2011088201A1 (en) | 2010-01-14 | 2011-01-13 | Voltage-gated sodium channel blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013517283A JP2013517283A (ja) | 2013-05-16 |
| JP2013517283A5 true JP2013517283A5 (OSRAM) | 2014-03-13 |
Family
ID=44304640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549074A Pending JP2013517283A (ja) | 2010-01-14 | 2011-01-13 | 電位依存性ナトリウムチャネル遮断薬 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20130023541A1 (OSRAM) |
| EP (1) | EP2523665A4 (OSRAM) |
| JP (1) | JP2013517283A (OSRAM) |
| KR (1) | KR20120124064A (OSRAM) |
| CN (1) | CN102802627A (OSRAM) |
| AR (1) | AR079906A1 (OSRAM) |
| AU (1) | AU2011205302B2 (OSRAM) |
| BR (1) | BR112012017266A2 (OSRAM) |
| CA (1) | CA2787025A1 (OSRAM) |
| CL (1) | CL2012001971A1 (OSRAM) |
| CO (1) | CO6592051A2 (OSRAM) |
| CR (1) | CR20120402A (OSRAM) |
| EA (1) | EA201290644A1 (OSRAM) |
| IL (1) | IL220836A0 (OSRAM) |
| MA (1) | MA33987B1 (OSRAM) |
| MX (1) | MX2012008285A (OSRAM) |
| NZ (1) | NZ601126A (OSRAM) |
| PE (1) | PE20121518A1 (OSRAM) |
| PH (1) | PH12012501421A1 (OSRAM) |
| SG (1) | SG182400A1 (OSRAM) |
| TW (1) | TW201139406A (OSRAM) |
| UY (1) | UY33186A (OSRAM) |
| WO (1) | WO2011088201A1 (OSRAM) |
| ZA (1) | ZA201205126B (OSRAM) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8912196B2 (en) | 2009-05-27 | 2014-12-16 | Atir Holding S.A. | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use |
| KR101178181B1 (ko) * | 2010-09-17 | 2012-09-19 | 대한민국(농촌진흥청장) | 신규한 항생활성 화합물 및 그 화합물을 포함하는 항생 조성물 |
| WO2012049555A1 (en) | 2010-10-13 | 2012-04-19 | Lupin Limited | Spirocyclic compounds as voltage-gated sodium channel modulators |
| WO2013006596A1 (en) * | 2011-07-06 | 2013-01-10 | Glaxo Group Limited | Voltage-gated sodium channel blockers |
| CA2853439A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| CA2855019A1 (en) * | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| JP6242810B2 (ja) | 2011-12-28 | 2017-12-06 | グローバル・ブラッド・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｌｏｏｄ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法 |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| WO2013177224A1 (en) | 2012-05-22 | 2013-11-28 | Genentech, Inc. | N-substituted benzamides and their use in the treatment of pain |
| BR112015000187A2 (pt) | 2012-07-06 | 2017-06-27 | Genentech Inc | benzamidas substituídas com n e métodos de uso das mesmas |
| CA2882132C (en) * | 2012-08-16 | 2021-07-06 | The Scripps Research Institute | Kappa opioid ligands |
| BR112015022488A2 (pt) | 2013-03-14 | 2017-07-18 | Genentech Inc | triazolopiridinas substituídas e métodos de uso das mesmas |
| ES2663798T3 (es) * | 2013-03-14 | 2018-04-17 | Daiichi Sankyo Company, Limited | Fármaco para enfermedades respiratorias |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| ES2993155T3 (en) | 2013-03-15 | 2024-12-23 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| SG11201507320QA (en) | 2013-03-15 | 2015-10-29 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| SG11201507453VA (en) | 2013-03-15 | 2015-10-29 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EP2970156B1 (en) | 2013-03-15 | 2018-07-25 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014150289A1 (en) * | 2013-03-15 | 2014-09-25 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| WO2014165816A1 (en) | 2013-04-05 | 2014-10-09 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| JP6383418B2 (ja) | 2013-11-27 | 2018-08-29 | ジェネンテック， インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
| WO2015088864A1 (en) * | 2013-12-09 | 2015-06-18 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists |
| JP6045487B2 (ja) * | 2013-12-25 | 2016-12-14 | シャープ株式会社 | 操作入力システム、電子機器、携帯端末、及び操作入力方法 |
| PL3102208T5 (pl) | 2014-02-07 | 2024-10-14 | Global Blood Therapeutics, Inc. | Krystaliczny polimorf wolnej zasady 2-hydroksy-6-((2-(1-izopropylo-1h-pirazol-5-ilo)pirydyn-3-ylo)metoksy)benzaldehydu |
| AU2015223049B2 (en) * | 2014-02-27 | 2019-03-21 | Merck Patent Gmbh | Heterocyclic compounds as NaV channel inhibitors and uses thereof |
| US20170137415A1 (en) | 2014-03-29 | 2017-05-18 | Lupin Limited | Sulfonamide compounds as voltage gated sodium channel modulators |
| EP3166939B1 (en) | 2014-07-07 | 2019-06-05 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| WO2016021742A1 (en) | 2014-08-07 | 2016-02-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds as ep4 receptor antagonists |
| CR20170591A (es) | 2015-05-22 | 2018-05-07 | Genentech Inc | Benzamidas sustituidas y métodos para utilizarlas |
| EP3341353A1 (en) | 2015-08-27 | 2018-07-04 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| TW201722938A (zh) | 2015-09-04 | 2017-07-01 | 魯賓有限公司 | 作為電位閘控鈉通道調節子之磺醯胺化合物 |
| PE20181003A1 (es) | 2015-09-28 | 2018-06-26 | Genentech Inc | Compuestos terapeuticos y sus metodos de uso |
| WO2017091592A1 (en) | 2015-11-25 | 2017-06-01 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| ES3039236T3 (en) | 2015-12-04 | 2025-10-20 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| CN108430969B (zh) * | 2016-02-03 | 2020-06-02 | 上海海雁医药科技有限公司 | 杂环取代的n-磺酰基苯甲酰胺衍生物、其制法与医药上的用途 |
| EP3436432B1 (en) | 2016-03-30 | 2021-01-27 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| MA46546A (fr) | 2016-10-17 | 2021-05-05 | Genentech Inc | Composés thérapeutiques et leurs procédés d'utilisation |
| WO2018163077A1 (en) | 2017-03-08 | 2018-09-13 | Lupin Limited | Indanyl compounds as voltage gated sodium channel modulators |
| EP3601273B1 (en) | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| WO2019165290A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
| CN111936494A (zh) | 2018-03-30 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 作为钠通道抑制剂的取代的氢-吡啶并-吖嗪 |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| CN109796402A (zh) * | 2018-12-28 | 2019-05-24 | 京博农化科技有限公司 | 一种烟嘧磺隆中间体2-氯-n，n-二甲基烟酰胺的制备方法 |
| KR102845511B1 (ko) * | 2019-02-08 | 2025-08-12 | 삼성디스플레이 주식회사 | 축합환 화합물 및 이를 포함한 유기 발광 소자 |
| WO2020179859A1 (ja) | 2019-03-06 | 2020-09-10 | 第一三共株式会社 | ピロロピラゾール誘導体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297441A (zh) * | 1998-04-20 | 2001-05-30 | Basf公司 | 用作为钙蛋白酶抑制剂的杂环取代酰胺 |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| EP1638955A2 (en) * | 2003-07-02 | 2006-03-29 | Vertex Pharmaceuticals Incorporated | Pyrimidines useful as modulators of voltage-gated ion channels |
| GB0520581D0 (en) * | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| GB0520578D0 (en) * | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| JP2009520700A (ja) * | 2005-12-21 | 2009-05-28 | ペインセプター ファーマ コーポレーション | 依存性イオンチャネルを調節するための組成物および方法 |
| AU2008247102B2 (en) * | 2007-05-03 | 2011-11-24 | Pfizer Limited | 2 -pyridine carboxamide derivatives as sodium channel modulators |
| WO2008147864A2 (en) * | 2007-05-22 | 2008-12-04 | Xenon Pharmaceuticals Inc. | Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| TW201024282A (en) * | 2008-11-20 | 2010-07-01 | Orion Corp | New pharmaceutical compounds |
-
2011
- 2011-01-12 TW TW100101047A patent/TW201139406A/zh unknown
- 2011-01-13 WO PCT/US2011/021114 patent/WO2011088201A1/en not_active Ceased
- 2011-01-13 MA MA35122A patent/MA33987B1/fr unknown
- 2011-01-13 EP EP11733370.8A patent/EP2523665A4/en not_active Withdrawn
- 2011-01-13 KR KR1020127021186A patent/KR20120124064A/ko not_active Withdrawn
- 2011-01-13 JP JP2012549074A patent/JP2013517283A/ja active Pending
- 2011-01-13 CN CN2011800141112A patent/CN102802627A/zh active Pending
- 2011-01-13 NZ NZ601126A patent/NZ601126A/en not_active IP Right Cessation
- 2011-01-13 PH PH1/2012/501421A patent/PH12012501421A1/en unknown
- 2011-01-13 AU AU2011205302A patent/AU2011205302B2/en not_active Ceased
- 2011-01-13 PE PE2012000982A patent/PE20121518A1/es not_active Application Discontinuation
- 2011-01-13 US US13/522,183 patent/US20130023541A1/en not_active Abandoned
- 2011-01-13 MX MX2012008285A patent/MX2012008285A/es not_active Application Discontinuation
- 2011-01-13 CA CA2787025A patent/CA2787025A1/en not_active Abandoned
- 2011-01-13 BR BR112012017266A patent/BR112012017266A2/pt not_active IP Right Cessation
- 2011-01-13 EA EA201290644A patent/EA201290644A1/ru unknown
- 2011-01-13 SG SG2012050068A patent/SG182400A1/en unknown
- 2011-01-14 UY UY33186A patent/UY33186A/es not_active Application Discontinuation
- 2011-01-14 AR ARP110100127A patent/AR079906A1/es unknown
-
2012
- 2012-07-09 IL IL220836A patent/IL220836A0/en unknown
- 2012-07-10 ZA ZA2012/05126A patent/ZA201205126B/en unknown
- 2012-07-13 CO CO12118387A patent/CO6592051A2/es active IP Right Grant
- 2012-07-13 CL CL2012001971A patent/CL2012001971A1/es unknown
- 2012-07-31 CR CR20120402A patent/CR20120402A/es unknown
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