JP2006522746A5 - - Google Patents

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Publication number

JP2006522746A5

JP2006522746A5 JP2006504353A JP2006504353A JP2006522746A5 JP 2006522746 A5 JP2006522746 A5 JP 2006522746A5 JP 2006504353 A JP2006504353 A JP 2006504353A JP 2006504353 A JP2006504353 A JP 2006504353A JP 2006522746 A5 JP2006522746 A5 JP 2006522746A5

Authority

JP

Japan

Prior art keywords

alkyl

aryl

phenyl

hetaryl

methyl

Prior art date

2004-04-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 125000003118 aryl group Chemical group 0.000 claims 426
• 125000001072 heteroaryl group Chemical group 0.000 claims 312
• 125000000217 alkyl group Chemical group 0.000 claims 182
• 125000000753 cycloalkyl group Chemical group 0.000 claims 125
• 229910052739 hydrogen Inorganic materials 0.000 claims 117
• 239000001257 hydrogen Substances 0.000 claims 117
• -1 aryl-C 1 -C 6 alkyl Chemical group 0.000 claims 107
• 150000002431 hydrogen Chemical class 0.000 claims 103
• 125000004122 cyclic group Chemical group 0.000 claims 94
• 150000001875 compounds Chemical class 0.000 claims 88
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 77
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 72
• 125000004043 oxo group Chemical group O=* 0.000 claims 69
• 125000004093 cyano group Chemical group *C#N 0.000 claims 68
• 229910052757 nitrogen Inorganic materials 0.000 claims 64
• 239000000203 mixture Substances 0.000 claims 62
• 230000003287 optical effect Effects 0.000 claims 60
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 57
• 125000005843 halogen group Chemical group 0.000 claims 56
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 54
• 125000005129 aryl carbonyl group Chemical group 0.000 claims 51
• 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 49
• 229910052760 oxygen Inorganic materials 0.000 claims 41
• 125000004104 aryloxy group Chemical group 0.000 claims 40
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 39
• 239000001301 oxygen Chemical group 0.000 claims 39
• 229920006395 saturated elastomer Polymers 0.000 claims 37
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 36
• 125000004953 trihalomethyl group Chemical group 0.000 claims 35
• 125000004432 carbon atom Chemical group C* 0.000 claims 34
• 125000005842 heteroatom Chemical group 0.000 claims 33
• 229910052717 sulfur Chemical group 0.000 claims 33
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 31
• 125000002619 bicyclic group Chemical group 0.000 claims 31
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 31
• 239000011593 sulfur Chemical group 0.000 claims 31
• 239000002253 acid Substances 0.000 claims 30
• 150000003839 salts Chemical class 0.000 claims 27
• 239000008194 pharmaceutical composition Substances 0.000 claims 22
• 239000000651 prodrug Chemical class 0.000 claims 20
• 229940002612 prodrug Drugs 0.000 claims 20
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 15
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 12
• 208000002705 Glucose Intolerance Diseases 0.000 claims 9
• 125000005157 alkyl carboxy group Chemical group 0.000 claims 9
• 125000005110 aryl thio group Chemical group 0.000 claims 9
• 201000009104 prediabetes syndrome Diseases 0.000 claims 9
• 125000003342 alkenyl group Chemical group 0.000 claims 8
• 125000003710 aryl alkyl group Chemical group 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 8
• 125000004951 trihalomethoxy group Chemical group 0.000 claims 8
• 229910052799 carbon Inorganic materials 0.000 claims 7
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 6
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 6
• 125000000304 alkynyl group Chemical group 0.000 claims 6
• 150000001408 amides Chemical class 0.000 claims 6
• 229940079593 drug Drugs 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• 230000000694 effects Effects 0.000 claims 6
• 230000002401 inhibitory effect Effects 0.000 claims 6
• 230000002265 prevention Effects 0.000 claims 6
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 6
• 150000007513 acids Chemical class 0.000 claims 5
• 230000001629 suppression Effects 0.000 claims 5
• 208000024891 symptom Diseases 0.000 claims 5
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 4
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
• JFUAWXPBHXKZGA-IBGZPJMESA-N 4-fluoro-2-[(4r)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol Chemical compound C([C@@](O)(CC=1NC2=CN=CC=C2C=1)C(F)(F)F)C(C)(C)C1=CC(F)=CC=C1O JFUAWXPBHXKZGA-IBGZPJMESA-N 0.000 claims 3
• ABWXVHBJBCOILL-UHFFFAOYSA-N 5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxylic acid Chemical compound C1=C2NC=C(C(O)=O)C2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 ABWXVHBJBCOILL-UHFFFAOYSA-N 0.000 claims 3
• 208000032928 Dyslipidaemia Diseases 0.000 claims 3
• 206010020772 Hypertension Diseases 0.000 claims 3
• 206010022489 Insulin Resistance Diseases 0.000 claims 3
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 3
• 208000008589 Obesity Diseases 0.000 claims 3
• 125000003545 alkoxy group Chemical group 0.000 claims 3
• 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 3
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
• 208000035475 disorder Diseases 0.000 claims 3
• 239000003862 glucocorticoid Substances 0.000 claims 3
• 229940124750 glucocorticoid receptor agonist Drugs 0.000 claims 3
• 230000002641 glycemic effect Effects 0.000 claims 3
• 230000005764 inhibitory process Effects 0.000 claims 3
• 230000003834 intracellular effect Effects 0.000 claims 3
• 235000020824 obesity Nutrition 0.000 claims 3
• 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 3
• 238000002560 therapeutic procedure Methods 0.000 claims 3
• JIUOGBKTFGUCKG-UHFFFAOYSA-N (2,3-dimethyl-2,3-dihydro-1-benzofuran-7-yl)-(2,4,4-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)methanone Chemical compound C1C(C(CC2(C)C)C)CC2N1C(=O)C1=CC=CC2=C1OC(C)C2C JIUOGBKTFGUCKG-UHFFFAOYSA-N 0.000 claims 2
• LXQSIAQMHYWPIO-UHFFFAOYSA-N (2-methyl-2,3-dihydro-1-benzofuran-7-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=C(OC(C)C2)C2=CC=C1 LXQSIAQMHYWPIO-UHFFFAOYSA-N 0.000 claims 2
• 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 2
• 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 2
• QMKZALHDMMUQNX-UHFFFAOYSA-N 1-benzyl-n-cyclohexyl-n-methylbenzimidazole-5-carboxamide Chemical compound C=1C=C2N(CC=3C=CC=CC=3)C=NC2=CC=1C(=O)N(C)C1CCCCC1 QMKZALHDMMUQNX-UHFFFAOYSA-N 0.000 claims 2
• YBJYREROQOWSCS-UHFFFAOYSA-N 1h-indol-4-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CC=CC2=C1C=CN2 YBJYREROQOWSCS-UHFFFAOYSA-N 0.000 claims 2
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
• LPQUUTFFETVGJJ-UHFFFAOYSA-N 3h-benzimidazol-5-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=C2NC=NC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 LPQUUTFFETVGJJ-UHFFFAOYSA-N 0.000 claims 2
• UTJJXMWOLIFXSW-UHFFFAOYSA-N 4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxylic acid Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CC=CC2=C1C(C(O)=O)=CN2 UTJJXMWOLIFXSW-UHFFFAOYSA-N 0.000 claims 2
• 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 2
• 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 2
• 125000005599 alkyl carboxylate group Chemical group 0.000 claims 2
• MWDZXZKOPKCTPO-UHFFFAOYSA-N azepan-1-yl-(2-bromophenyl)methanone Chemical compound BrC1=CC=CC=C1C(=O)N1CCCCCC1 MWDZXZKOPKCTPO-UHFFFAOYSA-N 0.000 claims 2
• 230000009286 beneficial effect Effects 0.000 claims 2
• 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
• 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• NLJZAYLGIPDZGA-UHFFFAOYSA-N ethyl 4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxylate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=C2C(C(=O)OCC)=CNC2=CC=C1 NLJZAYLGIPDZGA-UHFFFAOYSA-N 0.000 claims 2
• JIXJXXDPKZYNSE-UHFFFAOYSA-N methyl 2-[[2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanoyl]amino]-3-methylbutanoate Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C(=O)NC(C(=O)OC)C(C)C)CC1=CC=CC=C1 JIXJXXDPKZYNSE-UHFFFAOYSA-N 0.000 claims 2
• GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 2
• RCKNUVPBRDBVSE-UHFFFAOYSA-N n-cyclohexyl-4-methoxy-n,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide Chemical compound C1=2OC(C)CC=2C(OC)=CC=C1C(=O)N(C)C1CCCCC1 RCKNUVPBRDBVSE-UHFFFAOYSA-N 0.000 claims 2
• DBEMVIYWKXVVJH-UHFFFAOYSA-N n-cyclohexyl-n,2,2-trimethyl-3h-1-benzofuran-7-carboxamide Chemical compound C=1C=CC=2CC(C)(C)OC=2C=1C(=O)N(C)C1CCCCC1 DBEMVIYWKXVVJH-UHFFFAOYSA-N 0.000 claims 2
• CAWIYIDNMZGWIK-UHFFFAOYSA-N n-cyclohexyl-n,2-dimethyl-1-benzofuran-7-carboxamide Chemical compound C=1C=CC=2C=C(C)OC=2C=1C(=O)N(C)C1CCCCC1 CAWIYIDNMZGWIK-UHFFFAOYSA-N 0.000 claims 2
• NSYOBPNVQIMPIP-UHFFFAOYSA-N n-cyclohexyl-n,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide Chemical compound C=12OC(C)CC2=CC=CC=1C(=O)N(C)C1CCCCC1 NSYOBPNVQIMPIP-UHFFFAOYSA-N 0.000 claims 2
• PEAHQSRCMVXFAQ-UHFFFAOYSA-N n-cyclohexyl-n,3,3-trimethyl-2h-1-benzofuran-7-carboxamide Chemical compound C=1C=CC(C(CO2)(C)C)=C2C=1C(=O)N(C)C1CCCCC1 PEAHQSRCMVXFAQ-UHFFFAOYSA-N 0.000 claims 2
• YFTGHOAECAOWNS-UHFFFAOYSA-N n-cyclohexyl-n-methyl-1-benzofuran-7-carboxamide Chemical compound C=1C=CC=2C=COC=2C=1C(=O)N(C)C1CCCCC1 YFTGHOAECAOWNS-UHFFFAOYSA-N 0.000 claims 2
• JYAVVQOYTNZFLK-UHFFFAOYSA-N n-cyclohexyl-n-methyl-2,3-dihydro-1-benzofuran-7-carboxamide Chemical compound C=1C=CC=2CCOC=2C=1C(=O)N(C)C1CCCCC1 JYAVVQOYTNZFLK-UHFFFAOYSA-N 0.000 claims 2
• SLKYTAURFTYGTP-UHFFFAOYSA-N n-cyclohexyl-n-methyl-3,4-dihydro-2h-chromene-8-carboxamide Chemical compound C=1C=CC=2CCCOC=2C=1C(=O)N(C)C1CCCCC1 SLKYTAURFTYGTP-UHFFFAOYSA-N 0.000 claims 2
• 238000007911 parenteral administration Methods 0.000 claims 2
• 230000002685 pulmonary effect Effects 0.000 claims 2
• CLUYZQSZTNASQA-UHFFFAOYSA-N (1-benzoyl-3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-4-yl) acetate Chemical compound C12CCCCC2C(OC(=O)C)CCN1C(=O)C1=CC=CC=C1 CLUYZQSZTNASQA-UHFFFAOYSA-N 0.000 claims 1
• AZFUUABVSMLYRP-UHFFFAOYSA-N (1-benzoyl-3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-4-yl) benzoate Chemical compound C=1C=CC=CC=1C(=O)OC(C1CCCCC11)CCN1C(=O)C1=CC=CC=C1 AZFUUABVSMLYRP-UHFFFAOYSA-N 0.000 claims 1
• BMLIDECJNRNSHL-UHFFFAOYSA-N (1-benzylindol-5-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1C=C2)=CC=C1N2CC1=CC=CC=C1 BMLIDECJNRNSHL-UHFFFAOYSA-N 0.000 claims 1
• IPLWYRCWVAYSEZ-UHFFFAOYSA-N (1-methylimidazol-4-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound CN1C=NC(C(=O)N2C3CC(CC(C)(C)C3)(C)C2)=C1 IPLWYRCWVAYSEZ-UHFFFAOYSA-N 0.000 claims 1
• KFHYYYGYJBLDOK-UHFFFAOYSA-N (1-methylindol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)N1C(CC(C)(C)C2)CC2(C)C1 KFHYYYGYJBLDOK-UHFFFAOYSA-N 0.000 claims 1
• ZOAVGLBIANTSJX-UHFFFAOYSA-N (1-methylindol-3-yl)-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=CN(C)C2=CC=CC=C12 ZOAVGLBIANTSJX-UHFFFAOYSA-N 0.000 claims 1
• NZUNGIINGQDGTI-UHFFFAOYSA-N (1-methylindol-5-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2N(C)C=CC2=C1 NZUNGIINGQDGTI-UHFFFAOYSA-N 0.000 claims 1
• OXKSNWLCYHGWDF-UHFFFAOYSA-N (1-thiophen-2-ylsulfonylpiperidin-4-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(CC1)CCN1S(=O)(=O)C1=CC=CS1 OXKSNWLCYHGWDF-UHFFFAOYSA-N 0.000 claims 1
• GGNQJVKCOPVNOK-UHFFFAOYSA-N (2,3-diphenylquinoxalin-6-yl)-(3,3,4-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)C(C)C(C2)CC1N2C(=O)C(C=C1N=C2C=3C=CC=CC=3)=CC=C1N=C2C1=CC=CC=C1 GGNQJVKCOPVNOK-UHFFFAOYSA-N 0.000 claims 1
• UJQUKEIBLJBZJA-UHFFFAOYSA-N (2,4-dichlorophenyl)-(2,6-dimethylpiperidin-1-yl)methanone Chemical compound CC1CCCC(C)N1C(=O)C1=CC=C(Cl)C=C1Cl UJQUKEIBLJBZJA-UHFFFAOYSA-N 0.000 claims 1
• ZZSOBOHKBAXQAV-UHFFFAOYSA-N (2,4-dichlorophenyl)-(3-methylpiperidin-1-yl)methanone Chemical compound C1C(C)CCCN1C(=O)C1=CC=C(Cl)C=C1Cl ZZSOBOHKBAXQAV-UHFFFAOYSA-N 0.000 claims 1
• FFXYESGVDUPGOI-UHFFFAOYSA-N (2,4-dimethyl-1,3-thiazol-5-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound S1C(C)=NC(C)=C1C(=O)N1C(CC(C)(C)C2)CC2(C)C1 FFXYESGVDUPGOI-UHFFFAOYSA-N 0.000 claims 1
• XBIJZNBGMGMZBR-UHFFFAOYSA-N (2,5-dichlorophenyl)-(4-methylpiperidin-1-yl)methanone Chemical compound C1CC(C)CCN1C(=O)C1=CC(Cl)=CC=C1Cl XBIJZNBGMGMZBR-UHFFFAOYSA-N 0.000 claims 1
• NNTUSYMOTQWYOW-UHFFFAOYSA-N (2,6-dimethylmorpholin-4-yl)-[4-(naphthalen-1-yloxymethyl)phenyl]methanone Chemical compound C1C(C)OC(C)CN1C(=O)C(C=C1)=CC=C1COC1=CC=CC2=CC=CC=C12 NNTUSYMOTQWYOW-UHFFFAOYSA-N 0.000 claims 1
• ZGQCDPXTQARJRN-UHFFFAOYSA-N (2,6-dimethylmorpholin-4-yl)-[4-(naphthalen-2-yloxymethyl)phenyl]methanone Chemical compound C1C(C)OC(C)CN1C(=O)C(C=C1)=CC=C1COC1=CC=C(C=CC=C2)C2=C1 ZGQCDPXTQARJRN-UHFFFAOYSA-N 0.000 claims 1
• MHWRFYDYSHKIOZ-UHFFFAOYSA-N (2,6-dimethylpiperidin-1-yl)-(4-phenylphenyl)methanone Chemical compound CC1CCCC(C)N1C(=O)C1=CC=C(C=2C=CC=CC=2)C=C1 MHWRFYDYSHKIOZ-UHFFFAOYSA-N 0.000 claims 1
• ONRXQJYDOVSGII-UHFFFAOYSA-N (2,6-dimethylpiperidin-1-yl)-[5-[(2,3,5,6-tetrafluorophenoxy)methyl]furan-2-yl]methanone Chemical compound CC1CCCC(C)N1C(=O)C(O1)=CC=C1COC1=C(F)C(F)=CC(F)=C1F ONRXQJYDOVSGII-UHFFFAOYSA-N 0.000 claims 1
• CGDBBVPEBGIJLJ-UHFFFAOYSA-N (2-amino-3h-benzimidazol-5-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=C2NC(N)=NC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 CGDBBVPEBGIJLJ-UHFFFAOYSA-N 0.000 claims 1
• QTLCXGYKTPZNJP-UHFFFAOYSA-N (2-benzylsulfanylphenyl)-morpholin-4-ylmethanone Chemical compound C=1C=CC=C(SCC=2C=CC=CC=2)C=1C(=O)N1CCOCC1 QTLCXGYKTPZNJP-UHFFFAOYSA-N 0.000 claims 1
• WJJUUUMYJRYAGW-UHFFFAOYSA-N (2-chloro-5,6-difluoro-3-methylphenyl)-(4-methylpiperidin-1-yl)methanone Chemical compound C1CC(C)CCN1C(=O)C1=C(F)C(F)=CC(C)=C1Cl WJJUUUMYJRYAGW-UHFFFAOYSA-N 0.000 claims 1
• AHTJWUMMSUABIS-UHFFFAOYSA-N (2-chlorophenyl)-(1,5,7-trimethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone Chemical compound C1C(C)(C2)CN(C)CC2(C)CN1C(=O)C1=CC=CC=C1Cl AHTJWUMMSUABIS-UHFFFAOYSA-N 0.000 claims 1
• YODXMLSIQUVJGG-UHFFFAOYSA-N (2-chlorophenyl)-(2-methylpiperidin-1-yl)methanone Chemical compound CC1CCCCN1C(=O)C1=CC=CC=C1Cl YODXMLSIQUVJGG-UHFFFAOYSA-N 0.000 claims 1
• RXWJONAUODBZSY-UHFFFAOYSA-N (2-chlorophenyl)-(3,5-dimethylpiperidin-1-yl)methanone Chemical compound C1C(C)CC(C)CN1C(=O)C1=CC=CC=C1Cl RXWJONAUODBZSY-UHFFFAOYSA-N 0.000 claims 1
• WLIZSQDLONVBDO-UHFFFAOYSA-N (2-chlorophenyl)-(3-methylpiperidin-1-yl)methanone Chemical compound C1C(C)CCCN1C(=O)C1=CC=CC=C1Cl WLIZSQDLONVBDO-UHFFFAOYSA-N 0.000 claims 1
• QPAATTRMFDTNHF-UHFFFAOYSA-N (2-chlorophenyl)-(6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)methanone Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)C1=CC=CC=C1Cl QPAATTRMFDTNHF-UHFFFAOYSA-N 0.000 claims 1
• RGFPLHGRASGMSG-UHFFFAOYSA-N (2-chlorophenyl)-piperidin-1-ylmethanone Chemical compound ClC1=CC=CC=C1C(=O)N1CCCCC1 RGFPLHGRASGMSG-UHFFFAOYSA-N 0.000 claims 1
• RVOGFGIPWLCTPQ-UHFFFAOYSA-N (2-methyl-3h-benzimidazol-5-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C(NC(C)=N2)C2=C1 RVOGFGIPWLCTPQ-UHFFFAOYSA-N 0.000 claims 1
• LDSRBZAVERTFSJ-UHFFFAOYSA-N (2-methylphenyl)-(2-methylpiperidin-1-yl)methanone Chemical compound CC1CCCCN1C(=O)C1=CC=CC=C1C LDSRBZAVERTFSJ-UHFFFAOYSA-N 0.000 claims 1
• PRHFZXTXSKXAOY-UHFFFAOYSA-N (2-methylpiperidin-1-yl)-quinolin-2-ylmethanone Chemical compound CC1CCCCN1C(=O)C1=CC=C(C=CC=C2)C2=N1 PRHFZXTXSKXAOY-UHFFFAOYSA-N 0.000 claims 1
• DWYUOHGJTPCLFC-UHFFFAOYSA-N (2-methylpyrazolo[1,5-a]pyridin-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=C2C=CC=CN2N=C1C DWYUOHGJTPCLFC-UHFFFAOYSA-N 0.000 claims 1
• FHOJLYASPAFRTD-UHFFFAOYSA-N (2-thiophen-2-yl-3h-benzimidazol-5-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1N=2)=CC=C1NC=2C1=CC=CS1 FHOJLYASPAFRTD-UHFFFAOYSA-N 0.000 claims 1
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• YQVFNVMYAHQUOB-UHFFFAOYSA-N (3,5-dimethylpiperidin-1-yl)-(3-methyl-4-nitrophenyl)methanone Chemical compound C1C(C)CC(C)CN1C(=O)C1=CC=C([N+]([O-])=O)C(C)=C1 YQVFNVMYAHQUOB-UHFFFAOYSA-N 0.000 claims 1
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• HUJVOAFQLBTOGP-UHFFFAOYSA-N (3-chlorophenyl)-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)methanone Chemical compound ClC1=CC=CC(C(=O)N2C3=CC=CC=C3CCC3=CC=CC=C32)=C1 HUJVOAFQLBTOGP-UHFFFAOYSA-N 0.000 claims 1
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• ANOFHXSKZHYANB-UHFFFAOYSA-N (4-amino-2-methoxyphenyl)-(4,4,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound COC1=CC(N)=CC=C1C(=O)N1C(CCC2(C)C)CC2(C)C1 ANOFHXSKZHYANB-UHFFFAOYSA-N 0.000 claims 1
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• XJCXJTTYTZQWJY-UHFFFAOYSA-N (4-ethoxyphenyl)-(4-methylpiperidin-1-yl)methanone Chemical compound C1=CC(OCC)=CC=C1C(=O)N1CCC(C)CC1 XJCXJTTYTZQWJY-UHFFFAOYSA-N 0.000 claims 1
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• RJTJHWUTEFLYIT-UHFFFAOYSA-N (4-imidazol-1-ylphenyl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1N1C=CN=C1 RJTJHWUTEFLYIT-UHFFFAOYSA-N 0.000 claims 1
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• TUPDNAUFOQVZDL-UHFFFAOYSA-N (4-methyl-2-phenyl-1,3-thiazol-5-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound S1C(C(=O)N2C3CC(CC(C)(C)C3)(C)C2)=C(C)N=C1C1=CC=CC=C1 TUPDNAUFOQVZDL-UHFFFAOYSA-N 0.000 claims 1
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• PUQVTVKVFZLLNO-UHFFFAOYSA-N (4-methylpiperidin-1-yl)-[4-(naphthalen-1-yloxymethyl)phenyl]methanone Chemical compound C1CC(C)CCN1C(=O)C(C=C1)=CC=C1COC1=CC=CC2=CC=CC=C12 PUQVTVKVFZLLNO-UHFFFAOYSA-N 0.000 claims 1
• AGMHVBMOFHSQOH-UHFFFAOYSA-N (4-methylsulfonylphenyl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CC=C(S(C)(=O)=O)C=C1 AGMHVBMOFHSQOH-UHFFFAOYSA-N 0.000 claims 1
• CPLHGZXBIRIPCH-UHFFFAOYSA-N (4-morpholin-4-ylsulfonylphenyl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1S(=O)(=O)N1CCOCC1 CPLHGZXBIRIPCH-UHFFFAOYSA-N 0.000 claims 1
• JCIJVASDCBGDOI-UHFFFAOYSA-N (4-nitrophenyl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CC=C([N+]([O-])=O)C=C1 JCIJVASDCBGDOI-UHFFFAOYSA-N 0.000 claims 1
• WRDJGRFGSJWADX-UHFFFAOYSA-N (4-phenoxyphenyl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1OC1=CC=CC=C1 WRDJGRFGSJWADX-UHFFFAOYSA-N 0.000 claims 1
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• UDJZUOQISGJKEM-UHFFFAOYSA-N (4-pyrazol-1-ylphenyl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1N1C=CC=N1 UDJZUOQISGJKEM-UHFFFAOYSA-N 0.000 claims 1
• NEQPSQNLANNXIT-UHFFFAOYSA-N (4-pyrrol-1-ylphenyl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1N1C=CC=C1 NEQPSQNLANNXIT-UHFFFAOYSA-N 0.000 claims 1
• MCAFPYGLGZLOSR-UHFFFAOYSA-N (4-tert-butylcyclohexyl) 4-oxo-4-piperidin-1-ylbutanoate Chemical compound C1CC(C(C)(C)C)CCC1OC(=O)CCC(=O)N1CCCCC1 MCAFPYGLGZLOSR-UHFFFAOYSA-N 0.000 claims 1
• AKKAEPNNCZKJEW-UHFFFAOYSA-N (4-tert-butylphenyl)-(3,4-dihydro-1h-isoquinolin-2-yl)methanone Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)N1CC2=CC=CC=C2CC1 AKKAEPNNCZKJEW-UHFFFAOYSA-N 0.000 claims 1
• RIOYYMWXYHNMFV-UHFFFAOYSA-N (4-tert-butylphenyl)-(3,5-dimethylpiperidin-1-yl)methanone Chemical compound C1C(C)CC(C)CN1C(=O)C1=CC=C(C(C)(C)C)C=C1 RIOYYMWXYHNMFV-UHFFFAOYSA-N 0.000 claims 1
• SWHJJCBDEZPXDK-UHFFFAOYSA-N (4-tert-butylpiperidin-1-yl)-(1h-indol-5-yl)methanone Chemical compound C1CC(C(C)(C)C)CCN1C(=O)C1=CC=C(NC=C2)C2=C1 SWHJJCBDEZPXDK-UHFFFAOYSA-N 0.000 claims 1
• UVPFTRNYXLMKBI-UHFFFAOYSA-N (4-tert-butylpiperidin-1-yl)-phenylmethanone Chemical compound C1CC(C(C)(C)C)CCN1C(=O)C1=CC=CC=C1 UVPFTRNYXLMKBI-UHFFFAOYSA-N 0.000 claims 1
• QNEWOOLTUCRPRE-UHFFFAOYSA-N (5-benzyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)-(1h-indol-5-yl)methanone Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N1CC2CC1CN2CC1=CC=CC=C1 QNEWOOLTUCRPRE-UHFFFAOYSA-N 0.000 claims 1
• ZVUBXZNFCSHIHY-UHFFFAOYSA-N (5-chloro-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=C(Cl)C=C2C(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1 ZVUBXZNFCSHIHY-UHFFFAOYSA-N 0.000 claims 1
• KAPCFYNJZGEHHE-UHFFFAOYSA-N (5-methoxy-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CNC2=CC=C(OC)C=C21 KAPCFYNJZGEHHE-UHFFFAOYSA-N 0.000 claims 1
• XKXHHPFVZIJSMO-UHFFFAOYSA-N (5-phenylmethoxy-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C1=C2)=CNC1=CC=C2OCC1=CC=CC=C1 XKXHHPFVZIJSMO-UHFFFAOYSA-N 0.000 claims 1
• SKBKNXKJJFNDEY-UHFFFAOYSA-N (6-fluoro-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound FC1=CC=C2C(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1 SKBKNXKJJFNDEY-UHFFFAOYSA-N 0.000 claims 1
• XTESOSQZUQYBLP-UHFFFAOYSA-N (6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)-(2-fluorophenyl)methanone Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)C1=CC=CC=C1F XTESOSQZUQYBLP-UHFFFAOYSA-N 0.000 claims 1
• LQPZEMSOVCESFL-UHFFFAOYSA-N (6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)N2C3=CC=C(F)C=C3CCC2C)=C1 LQPZEMSOVCESFL-UHFFFAOYSA-N 0.000 claims 1
• KDMOVEXDMQZEPS-UHFFFAOYSA-N (6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)-[3-(trifluoromethyl)phenyl]methanone Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)C1=CC=CC(C(F)(F)F)=C1 KDMOVEXDMQZEPS-UHFFFAOYSA-N 0.000 claims 1
• ZBCLYMFHPMQQSS-UHFFFAOYSA-N (6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)-phenylmethanone Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)C1=CC=CC=C1 ZBCLYMFHPMQQSS-UHFFFAOYSA-N 0.000 claims 1
• OWOBXOSMLOWFEN-UHFFFAOYSA-N (6-methoxy-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CNC2=CC(OC)=CC=C21 OWOBXOSMLOWFEN-UHFFFAOYSA-N 0.000 claims 1
• FGVHXWMGZMGETK-UHFFFAOYSA-N (6-methyl-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CNC2=CC(C)=CC=C21 FGVHXWMGZMGETK-UHFFFAOYSA-N 0.000 claims 1
• MUDWIJMMYALAGU-UHFFFAOYSA-N (6-nitro-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound [O-][N+](=O)C1=CC=C2C(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1 MUDWIJMMYALAGU-UHFFFAOYSA-N 0.000 claims 1
• SRLQPYSHHSLQKQ-UHFFFAOYSA-N (6-pyrazol-1-ylpyridin-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=N1)=CC=C1N1C=CC=N1 SRLQPYSHHSLQKQ-UHFFFAOYSA-N 0.000 claims 1
• HVMDTGSDSRRYTQ-UHFFFAOYSA-N (7-hydroxy-3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl)-phenylmethanone Chemical compound C12CC(O)CCC2CCCN1C(=O)C1=CC=CC=C1 HVMDTGSDSRRYTQ-UHFFFAOYSA-N 0.000 claims 1
• LBVCKSDEHLTWSN-UHFFFAOYSA-N (7-nitro-1h-indol-3-yl)-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=CC=C2C(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1[N+]([O-])=O LBVCKSDEHLTWSN-UHFFFAOYSA-N 0.000 claims 1
• NMKPJBQCDRCXCE-FMIVXFBMSA-N (e)-1-(3,4-dihydro-2h-quinolin-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one Chemical compound C1=CC(F)=CC=C1\C=C\C(=O)N1C2=CC=CC=C2CCC1 NMKPJBQCDRCXCE-FMIVXFBMSA-N 0.000 claims 1
• OOMKTYGUCMJELR-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1C2CCCCC2CCC1 OOMKTYGUCMJELR-UHFFFAOYSA-N 0.000 claims 1
• DWLZWPXFRMKZOE-UHFFFAOYSA-N 1,3-benzodioxol-5-yl(3,4-dihydro-2h-quinolin-1-yl)methanone Chemical compound C1=C2OCOC2=CC(C(N2C3=CC=CC=C3CCC2)=O)=C1 DWLZWPXFRMKZOE-UHFFFAOYSA-N 0.000 claims 1
• NGALFKPFMUEMSJ-UHFFFAOYSA-N 1,3-benzodioxol-5-yl-(4-benzylpiperidin-1-yl)methanone Chemical compound C=1C=C2OCOC2=CC=1C(=O)N(CC1)CCC1CC1=CC=CC=C1 NGALFKPFMUEMSJ-UHFFFAOYSA-N 0.000 claims 1
• XXJASKNHKIDKTP-UHFFFAOYSA-N 1-(1-adamantyl)-4-bromo-n,n-diethylpyrazole-3-carboxamide Chemical compound C1=C(Br)C(C(=O)N(CC)CC)=NN1C1(C2)CC(C3)CC2CC3C1 XXJASKNHKIDKTP-UHFFFAOYSA-N 0.000 claims 1
• DNEGOUQSPGEVCS-UHFFFAOYSA-N 1-(1h-indole-5-carbonyl)-4-phenylpiperidine-4-carbonitrile Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N(CC1)CCC1(C#N)C1=CC=CC=C1 DNEGOUQSPGEVCS-UHFFFAOYSA-N 0.000 claims 1
• HNQAMJPNGVKODD-UHFFFAOYSA-N 1-(2,3-dihydroindol-1-yl)-2-(4-methylphenyl)sulfanylethanone Chemical compound C1=CC(C)=CC=C1SCC(=O)N1C2=CC=CC=C2CC1 HNQAMJPNGVKODD-UHFFFAOYSA-N 0.000 claims 1
• RODREYUVBDOVGG-UHFFFAOYSA-N 1-(2,6-dimethylmorpholin-4-yl)-3,3-diphenylpropan-1-one Chemical compound C1C(C)OC(C)CN1C(=O)CC(C=1C=CC=CC=1)C1=CC=CC=C1 RODREYUVBDOVGG-UHFFFAOYSA-N 0.000 claims 1
• LFQXSKLNWOVHAF-UHFFFAOYSA-N 1-(3,4-dihydro-1h-isoquinolin-2-yl)-2-(2-methoxyphenyl)ethanone Chemical compound COC1=CC=CC=C1CC(=O)N1CC2=CC=CC=C2CC1 LFQXSKLNWOVHAF-UHFFFAOYSA-N 0.000 claims 1
• GLMROUFOILIMJW-UHFFFAOYSA-N 1-(3,4-dihydro-2h-quinolin-1-yl)-2-(1-naphthalen-1-yltetrazol-5-yl)sulfanylethanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)CSC1=NN=NN1C1=CC=CC2=CC=CC=C12 GLMROUFOILIMJW-UHFFFAOYSA-N 0.000 claims 1
• CJVWJHDVLKCEQQ-UHFFFAOYSA-N 1-(3,4-dihydro-2h-quinolin-1-yl)-2-(2-methylphenoxy)ethanone Chemical compound CC1=CC=CC=C1OCC(=O)N1C2=CC=CC=C2CCC1 CJVWJHDVLKCEQQ-UHFFFAOYSA-N 0.000 claims 1
• OOEQWCOFVOVUKD-UHFFFAOYSA-N 1-(3-azabicyclo[3.2.2]nonan-3-yl)-2-(1-methylindol-3-yl)ethanone Chemical compound C1CC(C2)CCC1CN2C(=O)CC1=CN(C)C2=CC=CC=C21 OOEQWCOFVOVUKD-UHFFFAOYSA-N 0.000 claims 1
• QFYYSPRBUSHJER-UHFFFAOYSA-N 1-(3-azabicyclo[3.2.2]nonan-3-yl)-2-(1h-indol-3-yl)ethanone Chemical compound C1CC(C2)CCC1CN2C(=O)CC1=CNC2=CC=CC=C12 QFYYSPRBUSHJER-UHFFFAOYSA-N 0.000 claims 1
• WLOBCFIHIQQBKX-UHFFFAOYSA-N 1-(4-aminophenyl)-n-cyclohexyl-n,5-dimethylpyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC(N)=CC=2)C(C)=C1C(=O)N(C)C1CCCCC1 WLOBCFIHIQQBKX-UHFFFAOYSA-N 0.000 claims 1
• JFUMQHLNKIOHTC-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[2-(4-chlorophenyl)-2-adamantyl]ethanone Chemical compound C1=CC(Cl)=CC=C1C1(CC(=O)N2CCN(CC=3C=CC=CC=3)CC2)C(C2)CC3CC2CC1C3 JFUMQHLNKIOHTC-UHFFFAOYSA-N 0.000 claims 1
• KKWSMSBRJWEUDS-UHFFFAOYSA-N 1-(4-benzylpiperidin-1-yl)-2-benzylsulfanylethanone Chemical compound C1CC(CC=2C=CC=CC=2)CCN1C(=O)CSCC1=CC=CC=C1 KKWSMSBRJWEUDS-UHFFFAOYSA-N 0.000 claims 1
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• SNVPQIRFGLLEPM-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-cyclohexyl-n,5-dimethylpyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC(Cl)=CC=2)C(C)=C1C(=O)N(C)C1CCCCC1 SNVPQIRFGLLEPM-UHFFFAOYSA-N 0.000 claims 1
• TXOIGTCLNINOIR-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-cyclohexyl-n-methyl-5-(trifluoromethyl)pyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC(Cl)=CC=2)C(C(F)(F)F)=C1C(=O)N(C)C1CCCCC1 TXOIGTCLNINOIR-UHFFFAOYSA-N 0.000 claims 1
• VQDYEQMWMKSMOT-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-cyclohexyl-n-methyl-5-propylpyrazole-4-carboxamide Chemical class CCCC1=C(C(=O)N(C)C2CCCCC2)C=NN1C1=CC=C(Cl)C=C1 VQDYEQMWMKSMOT-UHFFFAOYSA-N 0.000 claims 1
• JCTGUFVPNTUQRA-UHFFFAOYSA-N 1-(4-ethylbenzoyl)-6-methoxy-2-methyl-2,3-dihydroquinolin-4-one Chemical compound C1=CC(CC)=CC=C1C(=O)N1C2=CC=C(OC)C=C2C(=O)CC1C JCTGUFVPNTUQRA-UHFFFAOYSA-N 0.000 claims 1
• NNZRNJJASNQJBA-UHFFFAOYSA-N 1-(4-propylpiperazin-1-yl)-3-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C1CN(CCC)CCN1C(=O)CCC1=CC=C(C(F)(F)F)C=C1 NNZRNJJASNQJBA-UHFFFAOYSA-N 0.000 claims 1
• VAGSHINATNLVMH-UHFFFAOYSA-N 1-(azepan-1-yl)-3-(4-chlorophenyl)sulfanylpropan-1-one Chemical compound C1=CC(Cl)=CC=C1SCCC(=O)N1CCCCCC1 VAGSHINATNLVMH-UHFFFAOYSA-N 0.000 claims 1
• DMYFTZJMMDFIOF-UHFFFAOYSA-N 1-(azepane-1-carbonyl)fluoren-9-one Chemical compound C=1C=CC=2C3=CC=CC=C3C(=O)C=2C=1C(=O)N1CCCCCC1 DMYFTZJMMDFIOF-UHFFFAOYSA-N 0.000 claims 1
• NDFBRHTXABKGQJ-UHFFFAOYSA-N 1-(benzenesulfonyl)-n-cyclooctylpyrrolidine-2-carboxamide Chemical compound C1CCN(S(=O)(=O)C=2C=CC=CC=2)C1C(=O)NC1CCCCCCC1 NDFBRHTXABKGQJ-UHFFFAOYSA-N 0.000 claims 1
• GIGGJMZITBFZDE-UHFFFAOYSA-N 1-(thiophene-2-carbonyl)-2,3-dihydroquinolin-4-one Chemical compound C1CC(=O)C2=CC=CC=C2N1C(=O)C1=CC=CS1 GIGGJMZITBFZDE-UHFFFAOYSA-N 0.000 claims 1
• WNYBVVAIXGXJET-UHFFFAOYSA-N 1-[3-(4-bromophenyl)-1-(furan-2-yl)-3-oxopropyl]pyrrolidin-2-one Chemical compound C1=CC(Br)=CC=C1C(=O)CC(C=1OC=CC=1)N1C(=O)CCC1 WNYBVVAIXGXJET-UHFFFAOYSA-N 0.000 claims 1
• JQVYWCHUEKNOEK-UHFFFAOYSA-N 1-[3-acetyl-2-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indol-3-yl]-2h-imidazol-1-yl]ethanone Chemical compound CC(=O)N1C=CN(C(C)=O)C1C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 JQVYWCHUEKNOEK-UHFFFAOYSA-N 0.000 claims 1
• WCCDPYIVDDEHEQ-UHFFFAOYSA-N 1-[4-(3,3,4-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]pyrrolidine-2,5-dione Chemical compound C1C(C)(C)C(C)C(C2)CC1N2C(=O)C(C=C1)=CC=C1N1C(=O)CCC1=O WCCDPYIVDDEHEQ-UHFFFAOYSA-N 0.000 claims 1
• QIGHDXZWNDJYHM-UHFFFAOYSA-N 1-[4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]pyrrolidine-2,5-dione Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1N1C(=O)CCC1=O QIGHDXZWNDJYHM-UHFFFAOYSA-N 0.000 claims 1
• ZHXBSCJIMVEAAL-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-(5-methyl-2-propan-2-ylphenoxy)ethanone Chemical compound CC(C)C1=CC=C(C)C=C1OCC(=O)N1CCN(C=2C=CC(F)=CC=2)CC1 ZHXBSCJIMVEAAL-UHFFFAOYSA-N 0.000 claims 1
• UAMYCUQOFVOYRZ-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[(2-methylphenyl)methylsulfanyl]ethanone Chemical compound CC1=CC=CC=C1CSCC(=O)N1CCN(C=2C=CC(F)=CC=2)CC1 UAMYCUQOFVOYRZ-UHFFFAOYSA-N 0.000 claims 1
• DEUMLKARTVCBEE-UHFFFAOYSA-N 1-[4-(4-nitrophenyl)piperazin-1-yl]-3-phenylpropan-1-one Chemical compound C1=CC([N+](=O)[O-])=CC=C1N1CCN(C(=O)CCC=2C=CC=CC=2)CC1 DEUMLKARTVCBEE-UHFFFAOYSA-N 0.000 claims 1
• PASQHWJORBCPBF-UHFFFAOYSA-N 1-[4-(6-chloropyridin-2-yl)piperazin-1-yl]-2-(2-phenyl-2-adamantyl)ethanone Chemical compound ClC1=CC=CC(N2CCN(CC2)C(=O)CC2(C3CC4CC(C3)CC2C4)C=2C=CC=CC=2)=N1 PASQHWJORBCPBF-UHFFFAOYSA-N 0.000 claims 1
• DYVFLSCDPKBDMP-UHFFFAOYSA-N 1-adamantyl(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1CC(C2=CC=CC=C2N2)=C2CC1 DYVFLSCDPKBDMP-UHFFFAOYSA-N 0.000 claims 1
• HIBMQKCIYVQVAB-UHFFFAOYSA-N 1-adamantyl(3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1CC(N=CN2)=C2CC1 HIBMQKCIYVQVAB-UHFFFAOYSA-N 0.000 claims 1
• XICGPKIYVIIEFX-UHFFFAOYSA-N 1-adamantyl(azepan-1-yl)methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1CCCCCC1 XICGPKIYVIIEFX-UHFFFAOYSA-N 0.000 claims 1
• BURUIZXRHQWZQI-UHFFFAOYSA-N 1-adamantyl(piperidino)methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1CCCCC1 BURUIZXRHQWZQI-UHFFFAOYSA-N 0.000 claims 1
• RVXVNLMWQYKNHL-UHFFFAOYSA-N 1-adamantyl(pyrrolidin-1-yl)methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1CCCC1 RVXVNLMWQYKNHL-UHFFFAOYSA-N 0.000 claims 1
• WKNPJADWMJGKKT-UHFFFAOYSA-N 1-adamantyl-(2,6-dimethylpiperidin-1-yl)methanone Chemical compound CC1CCCC(C)N1C(=O)C1(C2)CC(C3)CC2CC3C1 WKNPJADWMJGKKT-UHFFFAOYSA-N 0.000 claims 1
• QTZKLNISANRGBJ-UHFFFAOYSA-N 1-adamantyl-(4-cyclopropyl-1,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1CCC=2NC=NC=2C1C1CC1 QTZKLNISANRGBJ-UHFFFAOYSA-N 0.000 claims 1
• LLZDWBMUURUCQW-UHFFFAOYSA-N 1-adamantyl-(4-methylpiperidin-1-yl)methanone Chemical compound C1CC(C)CCN1C(=O)C1(C2)CC(C3)CC2CC3C1 LLZDWBMUURUCQW-UHFFFAOYSA-N 0.000 claims 1
• ZKRNMJOSVPSYAG-UHFFFAOYSA-N 1-adamantyl-(4-phenylpiperidin-1-yl)methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N(CC1)CCC1C1=CC=CC=C1 ZKRNMJOSVPSYAG-UHFFFAOYSA-N 0.000 claims 1
• VKHJBJDJMJNHDQ-UHFFFAOYSA-N 1-adamantyl-[4-(1h-benzimidazol-2-ylsulfanyl)piperidin-1-yl]methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1CCC(SC=2NC3=CC=CC=C3N=2)CC1 VKHJBJDJMJNHDQ-UHFFFAOYSA-N 0.000 claims 1
• KSRHDINKWJNBBG-UHFFFAOYSA-N 1-adamantyl-[4-(2-methoxyphenyl)piperazin-1-yl]methanone Chemical compound COC1=CC=CC=C1N1CCN(C(=O)C23CC4CC(CC(C4)C2)C3)CC1 KSRHDINKWJNBBG-UHFFFAOYSA-N 0.000 claims 1
• AVSIUCLTZYKXIY-UHFFFAOYSA-N 1-adamantyl-[4-(trifluoromethyl)-1,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]methanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)N1C(C(F)(F)F)C(N=CN2)=C2CC1 AVSIUCLTZYKXIY-UHFFFAOYSA-N 0.000 claims 1
• MDLCFAQZWIHYFW-UHFFFAOYSA-N 1-benzofuran-2-yl-(4-phenylpiperidin-1-yl)methanone Chemical compound C=1C2=CC=CC=C2OC=1C(=O)N(CC1)CCC1C1=CC=CC=C1 MDLCFAQZWIHYFW-UHFFFAOYSA-N 0.000 claims 1
• LQAPDEWEHGIOSJ-UHFFFAOYSA-N 1-benzothiophen-3-yl-(6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)methanone Chemical compound C1=CC=C2C(C(=O)N3C4=CC=C(F)C=C4CCC3C)=CSC2=C1 LQAPDEWEHGIOSJ-UHFFFAOYSA-N 0.000 claims 1
• YUJUIPBGXOQXKA-UHFFFAOYSA-N 1-ethyl-3-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indol-3-yl]pyrrolidine-2,5-dione Chemical compound O=C1N(CC)C(=O)CC1C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 YUJUIPBGXOQXKA-UHFFFAOYSA-N 0.000 claims 1
• WDFXDCDTBGETBZ-UHFFFAOYSA-N 1-methyl-n-(2-methylpiperidin-1-yl)indole-3-carboxamide Chemical compound CC1CCCCN1NC(=O)C1=CN(C)C2=CC=CC=C12 WDFXDCDTBGETBZ-UHFFFAOYSA-N 0.000 claims 1
• SRUYSSQAJHSVRB-UHFFFAOYSA-N 1-methyl-n-(2-oxoazepan-3-yl)indole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NC1CCCCNC1=O SRUYSSQAJHSVRB-UHFFFAOYSA-N 0.000 claims 1
• WTALDMNFCQBHCT-UHFFFAOYSA-N 1-morpholin-4-yl-2-[3-(4-nitrophenyl)-1-adamantyl]ethanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1(C2)CC(CC(=O)N3CCOCC3)(C3)CC2CC3C1 WTALDMNFCQBHCT-UHFFFAOYSA-N 0.000 claims 1
• ZEFYGKFMGWFRFW-UHFFFAOYSA-N 1-octanoyl-4-phenylpiperidine-4-carbonitrile Chemical compound C1CN(C(=O)CCCCCCC)CCC1(C#N)C1=CC=CC=C1 ZEFYGKFMGWFRFW-UHFFFAOYSA-N 0.000 claims 1
• XSMXFGNEKPFTES-UHFFFAOYSA-N 1-phenyl-n-[(4-phenyloxan-4-yl)methyl]cyclopentane-1-carboxamide Chemical compound C1CCCC1(C=1C=CC=CC=1)C(=O)NCC1(C=2C=CC=CC=2)CCOCC1 XSMXFGNEKPFTES-UHFFFAOYSA-N 0.000 claims 1
• NKMVIVBZSDPXIO-UHFFFAOYSA-N 1h-imidazol-5-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CNC=N1 NKMVIVBZSDPXIO-UHFFFAOYSA-N 0.000 claims 1
• RPUJVSJHGXHSGV-UHFFFAOYSA-N 1h-indol-2-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=CC=C2NC(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CC2=C1 RPUJVSJHGXHSGV-UHFFFAOYSA-N 0.000 claims 1
• RNBNCLUSOOUPDD-UHFFFAOYSA-N 1h-indol-3-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=CC=C2C(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1 RNBNCLUSOOUPDD-UHFFFAOYSA-N 0.000 claims 1
• ZDARYQBTTLXSAW-UHFFFAOYSA-N 1h-indol-4-yl(piperidin-1-yl)methanone Chemical compound C=1C=CC=2NC=CC=2C=1C(=O)N1CCCCC1 ZDARYQBTTLXSAW-UHFFFAOYSA-N 0.000 claims 1
• URZDFIWYIIBQNA-UHFFFAOYSA-N 1h-indol-5-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=C2NC=CC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 URZDFIWYIIBQNA-UHFFFAOYSA-N 0.000 claims 1
• MQMVUBXPIHNHTG-UHFFFAOYSA-N 1h-indol-5-yl-(4-phenylpiperidin-1-yl)methanone Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N(CC1)CCC1C1=CC=CC=C1 MQMVUBXPIHNHTG-UHFFFAOYSA-N 0.000 claims 1
• DIVUGLHALPBSGO-UHFFFAOYSA-N 1h-indol-5-yl-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N(CC1)CCC1N1CCCC1 DIVUGLHALPBSGO-UHFFFAOYSA-N 0.000 claims 1
• MGXIIXQIKRNOLY-UHFFFAOYSA-N 1h-indol-6-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=C2C=CNC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 MGXIIXQIKRNOLY-UHFFFAOYSA-N 0.000 claims 1
• YXELWVOQOFNVTK-UHFFFAOYSA-N 1h-indol-7-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CC=CC2=C1NC=C2 YXELWVOQOFNVTK-UHFFFAOYSA-N 0.000 claims 1
• FXDYXPHSZLCDIM-UHFFFAOYSA-N 2,2-dimethyl-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)propan-1-one Chemical compound C1C2N(C(=O)C(C)(C)C)CC1(C)CC(C)(C)C2 FXDYXPHSZLCDIM-UHFFFAOYSA-N 0.000 claims 1
• GMMCOOOUDUJFSW-UHFFFAOYSA-N 2,2-dimethyl-n-(5-propyl-1,3,4-thiadiazol-2-yl)propanamide Chemical compound CCCC1=NN=C(NC(=O)C(C)(C)C)S1 GMMCOOOUDUJFSW-UHFFFAOYSA-N 0.000 claims 1
• DZLRDAUPHSQETM-UHFFFAOYSA-N 2,4-bis(phenylmethoxy)benzamide Chemical compound C1=C(OCC=2C=CC=CC=2)C(C(=O)N)=CC=C1OCC1=CC=CC=C1 DZLRDAUPHSQETM-UHFFFAOYSA-N 0.000 claims 1
• XOZFIDFWSRLTET-UHFFFAOYSA-N 2,4-dichloro-n-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)-n-methylbenzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)C(CC1)CCC21OCC(C)(C)CO2 XOZFIDFWSRLTET-UHFFFAOYSA-N 0.000 claims 1
• XTHOLULPJKNCNL-UHFFFAOYSA-N 2,4-dichloro-n-[2-(furan-2-ylmethyl)cyclohexyl]benzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)NC1C(CC=2OC=CC=2)CCCC1 XTHOLULPJKNCNL-UHFFFAOYSA-N 0.000 claims 1
• SYYLVEYCYAHMES-UHFFFAOYSA-N 2,4-dichloro-n-[3-(piperidine-1-carbonyl)phenyl]benzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)NC1=CC=CC(C(=O)N2CCCCC2)=C1 SYYLVEYCYAHMES-UHFFFAOYSA-N 0.000 claims 1
• GLXNSQWLLDTPEB-UHFFFAOYSA-N 2,4-dichloro-n-cyclohexyl-n-(2-hydroxyethyl)benzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(CCO)C1CCCCC1 GLXNSQWLLDTPEB-UHFFFAOYSA-N 0.000 claims 1
• AFILMNPEXDNCGQ-UHFFFAOYSA-N 2,4-dichloro-n-cyclohexyl-n-methylbenzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)C1CCCCC1 AFILMNPEXDNCGQ-UHFFFAOYSA-N 0.000 claims 1
• FLJCIOPUVWBENL-UHFFFAOYSA-N 2,4-dichloro-n-ethyl-n-(2-methylphenyl)benzamide Chemical compound C=1C=CC=C(C)C=1N(CC)C(=O)C1=CC=C(Cl)C=C1Cl FLJCIOPUVWBENL-UHFFFAOYSA-N 0.000 claims 1
• XDMKZNARJRZIFT-UHFFFAOYSA-N 2,4-dichloro-n-methyl-n-(4-oxocyclohexyl)benzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)C1CCC(=O)CC1 XDMKZNARJRZIFT-UHFFFAOYSA-N 0.000 claims 1
• SZZRVHTXVVVMLC-UHFFFAOYSA-N 2,6-difluoro-n-naphthalen-1-ylbenzamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC1=CC=CC2=CC=CC=C12 SZZRVHTXVVVMLC-UHFFFAOYSA-N 0.000 claims 1
• HYHXZYUFKVAWAB-UHFFFAOYSA-N 2-(1,3-benzothiazol-2-ylsulfanyl)-n-(2,4,4-trimethylpentan-2-yl)acetamide Chemical compound C1=CC=C2SC(SCC(=O)NC(C)(C)CC(C)(C)C)=NC2=C1 HYHXZYUFKVAWAB-UHFFFAOYSA-N 0.000 claims 1
• SZZZTWMTNQPXKL-UHFFFAOYSA-N 2-(1,3-benzothiazol-2-ylsulfanyl)-n-cyclohexylacetamide Chemical compound N=1C2=CC=CC=C2SC=1SCC(=O)NC1CCCCC1 SZZZTWMTNQPXKL-UHFFFAOYSA-N 0.000 claims 1
• KTPJCOZKVMXEGK-UHFFFAOYSA-N 2-(1,3-benzoxazol-2-ylsulfanyl)-n-(2,4,4-trimethylpentan-2-yl)acetamide Chemical compound C1=CC=C2OC(SCC(=O)NC(C)(C)CC(C)(C)C)=NC2=C1 KTPJCOZKVMXEGK-UHFFFAOYSA-N 0.000 claims 1
• ZJNKJHQMNJRKGE-UHFFFAOYSA-N 2-(1,3-dioxoisoindol-2-yl)-3-methyl-n-[2-(trifluoromethyl)phenyl]butanamide Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C(C)C)C(=O)NC1=CC=CC=C1C(F)(F)F ZJNKJHQMNJRKGE-UHFFFAOYSA-N 0.000 claims 1
• CHJOWHPQUASBRL-UHFFFAOYSA-N 2-(1-adamantyl)-1-(3,4-dihydro-1h-isoquinolin-2-yl)ethanone Chemical compound C1CC2=CC=CC=C2CN1C(=O)CC1(C2)CC(C3)CC2CC3C1 CHJOWHPQUASBRL-UHFFFAOYSA-N 0.000 claims 1
• DEOYDVAGDKZVNR-UHFFFAOYSA-N 2-(1-adamantyl)-n-[1-(2,5-dimethylphenyl)ethyl]acetamide Chemical compound C1C(C2)CC(C3)CC2CC13CC(=O)NC(C)C1=CC(C)=CC=C1C DEOYDVAGDKZVNR-UHFFFAOYSA-N 0.000 claims 1
• WSEBBPYBPPBTPA-UHFFFAOYSA-N 2-(1-adamantyl)-n-tert-butylacetamide Chemical compound C1C(C2)CC3CC2CC1(CC(=O)NC(C)(C)C)C3 WSEBBPYBPPBTPA-UHFFFAOYSA-N 0.000 claims 1
• ZGAFKODKTAZUCO-UHFFFAOYSA-N 2-(1-benzylimidazol-2-yl)sulfanyl-n-cyclohexylacetamide Chemical compound C1CCCCC1NC(=O)CSC1=NC=CN1CC1=CC=CC=C1 ZGAFKODKTAZUCO-UHFFFAOYSA-N 0.000 claims 1
• BPFIBMDESXSKSD-UHFFFAOYSA-N 2-(1-methylindol-3-yl)-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)ethanone Chemical compound C12=CC=CC=C2N(C)C=C1CC(=O)N1C(CC(C)(C)C2)CC2(C)C1 BPFIBMDESXSKSD-UHFFFAOYSA-N 0.000 claims 1
• ZZVHFDYCBPKARA-UHFFFAOYSA-N 2-(1h-indol-3-yl)-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)ethanone Chemical compound C1=CC=C2C(CC(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1 ZZVHFDYCBPKARA-UHFFFAOYSA-N 0.000 claims 1
• BXRMUOJFVNNURK-UHFFFAOYSA-N 2-(2,4-dichlorophenoxy)-n-(2-methylbutyl)propanamide Chemical compound CCC(C)CNC(=O)C(C)OC1=CC=C(Cl)C=C1Cl BXRMUOJFVNNURK-UHFFFAOYSA-N 0.000 claims 1
• PYYAWGIWWYJBNR-UHFFFAOYSA-N 2-(2,4-dimethylphenoxy)-1-(6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)ethanone Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)COC1=CC=C(C)C=C1C PYYAWGIWWYJBNR-UHFFFAOYSA-N 0.000 claims 1
• CHSYLCUXRJCXFN-UHFFFAOYSA-N 2-(2,6-dimethylphenoxy)-n-(2-propan-2-ylphenyl)acetamide Chemical compound CC(C)C1=CC=CC=C1NC(=O)COC1=C(C)C=CC=C1C CHSYLCUXRJCXFN-UHFFFAOYSA-N 0.000 claims 1
• VIGAKWPOIGTBHP-UHFFFAOYSA-N 2-(2-aminophenyl)sulfanyl-1-(5-fluoro-2,3-dihydroindol-1-yl)ethanone Chemical compound NC1=CC=CC=C1SCC(=O)N1C2=CC=C(F)C=C2CC1 VIGAKWPOIGTBHP-UHFFFAOYSA-N 0.000 claims 1
• QTDRMKNBWKWZAT-UHFFFAOYSA-N 2-(2-bromo-4-methylphenoxy)-n-[2-(cyclohexen-1-yl)ethyl]acetamide Chemical compound BrC1=CC(C)=CC=C1OCC(=O)NCCC1=CCCCC1 QTDRMKNBWKWZAT-UHFFFAOYSA-N 0.000 claims 1
• JBIMBKPZHTYYSV-UHFFFAOYSA-N 2-(2-cyanophenyl)sulfanyl-n-[2-(trifluoromethyl)phenyl]benzamide Chemical compound FC(F)(F)C1=CC=CC=C1NC(=O)C1=CC=CC=C1SC1=CC=CC=C1C#N JBIMBKPZHTYYSV-UHFFFAOYSA-N 0.000 claims 1
• RHIGPRNANIWPMK-UHFFFAOYSA-N 2-(2-cyanophenyl)sulfanyl-n-cyclopentylbenzamide Chemical compound C=1C=CC=C(SC=2C(=CC=CC=2)C#N)C=1C(=O)NC1CCCC1 RHIGPRNANIWPMK-UHFFFAOYSA-N 0.000 claims 1
• GYVNLDXQFZLUNN-UHFFFAOYSA-N 2-(2-ethylphenyl)sulfanyl-3-[methyl(2-pyridin-4-ylethyl)amino]-n-prop-2-ynylpropanamide Chemical compound CCC1=CC=CC=C1SC(C(=O)NCC#C)CN(C)CCC1=CC=NC=C1 GYVNLDXQFZLUNN-UHFFFAOYSA-N 0.000 claims 1
• XOBAUKAMJJYOQV-UHFFFAOYSA-N 2-(2-oxo-2-phenothiazin-10-ylethyl)-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione Chemical compound C12=CC=CC=C2SC2=CC=CC=C2N1C(=O)CN1C(=O)C2CCCCC2C1=O XOBAUKAMJJYOQV-UHFFFAOYSA-N 0.000 claims 1
• WINRQCKZGHXTHE-UHFFFAOYSA-N 2-(2-phenylethyl)-n-[2-(trifluoromethyl)phenyl]benzamide Chemical compound FC(F)(F)C1=CC=CC=C1NC(=O)C1=CC=CC=C1CCC1=CC=CC=C1 WINRQCKZGHXTHE-UHFFFAOYSA-N 0.000 claims 1
• FSBRTGBOSCGYHK-UHFFFAOYSA-N 2-(3,4-difluorophenyl)-n-[(4-hydroxyphenyl)methyl]-n-(thiophen-2-ylmethyl)acetamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CC=1C=C(F)C(F)=CC=1)CC1=CC=CS1 FSBRTGBOSCGYHK-UHFFFAOYSA-N 0.000 claims 1
• IMELXIOCAHSTMS-UHFFFAOYSA-N 2-(3-fluorophenyl)-n-[(4-hydroxyphenyl)methyl]-n-(4-methylhexan-2-yl)acetamide Chemical compound C=1C=CC(F)=CC=1CC(=O)N(C(C)CC(C)CC)CC1=CC=C(O)C=C1 IMELXIOCAHSTMS-UHFFFAOYSA-N 0.000 claims 1
• XGOIPSPRYYSFMC-UHFFFAOYSA-N 2-(3-oxo-3-phenylprop-1-enyl)isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C=CC(=O)C1=CC=CC=C1 XGOIPSPRYYSFMC-UHFFFAOYSA-N 0.000 claims 1
• BWSOOJDEOGMMRQ-UHFFFAOYSA-N 2-(4-aminophenyl)-n-cyclohexyl-n-methyl-3h-benzimidazole-5-carboxamide Chemical compound C=1C=C2NC(C=3C=CC(N)=CC=3)=NC2=CC=1C(=O)N(C)C1CCCCC1 BWSOOJDEOGMMRQ-UHFFFAOYSA-N 0.000 claims 1
• NYEUXEWXWIOAAX-UHFFFAOYSA-N 2-(4-chloro-2-methylphenoxy)-n-[2-(trifluoromethyl)phenyl]propanamide Chemical compound C=1C=CC=C(C(F)(F)F)C=1NC(=O)C(C)OC1=CC=C(Cl)C=C1C NYEUXEWXWIOAAX-UHFFFAOYSA-N 0.000 claims 1
• BYNQYIFSLUHTNV-UHFFFAOYSA-N 2-(4-chloro-2-methylphenoxy)-n-cycloheptylacetamide Chemical compound CC1=CC(Cl)=CC=C1OCC(=O)NC1CCCCCC1 BYNQYIFSLUHTNV-UHFFFAOYSA-N 0.000 claims 1
• UKQGYHOLIRSPTK-UHFFFAOYSA-N 2-(4-chloro-3,5-dimethylphenoxy)-n-cyclohexyl-n-methylacetamide Chemical compound C=1C(C)=C(Cl)C(C)=CC=1OCC(=O)N(C)C1CCCCC1 UKQGYHOLIRSPTK-UHFFFAOYSA-N 0.000 claims 1
• VGTHJTOHJMCXDJ-UHFFFAOYSA-N 2-(4-chloro-3-methylphenoxy)-n-cyclohexyl-n-methylacetamide Chemical compound C=1C=C(Cl)C(C)=CC=1OCC(=O)N(C)C1CCCCC1 VGTHJTOHJMCXDJ-UHFFFAOYSA-N 0.000 claims 1
• FOHQVDIHFKCOHQ-UHFFFAOYSA-N 2-(4-chlorophenoxy)-n-(2-fluoro-5-methylphenyl)-2-methylpropanamide Chemical compound CC1=CC=C(F)C(NC(=O)C(C)(C)OC=2C=CC(Cl)=CC=2)=C1 FOHQVDIHFKCOHQ-UHFFFAOYSA-N 0.000 claims 1
• KYADFMKHEIXPJH-UHFFFAOYSA-N 2-(4-chlorophenoxy)-n-[4-chloro-3-(trifluoromethyl)phenyl]acetamide Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)COC=2C=CC(Cl)=CC=2)=C1 KYADFMKHEIXPJH-UHFFFAOYSA-N 0.000 claims 1
• KHSBCQTVHXXWOR-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-n-[(2-hydroxyphenyl)methyl]-n-(2-methylpropyl)acetamide Chemical compound C=1C=C(O)C=CC=1CC(=O)N(CC(C)C)CC1=CC=CC=C1O KHSBCQTVHXXWOR-UHFFFAOYSA-N 0.000 claims 1
• ZCTNFXZCSTURDF-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-n-[(4-hydroxyphenyl)methyl]-n-(2-methylpropyl)acetamide Chemical compound C=1C=C(O)C=CC=1CC(=O)N(CC(C)C)CC1=CC=C(O)C=C1 ZCTNFXZCSTURDF-UHFFFAOYSA-N 0.000 claims 1
• MKNQAVLQSPCVCB-UHFFFAOYSA-N 2-(4-tert-butylphenoxy)-1-(4-ethylpiperazin-1-yl)ethanone Chemical compound C1CN(CC)CCN1C(=O)COC1=CC=C(C(C)(C)C)C=C1 MKNQAVLQSPCVCB-UHFFFAOYSA-N 0.000 claims 1
• NQYUAQXLGCYCTN-UHFFFAOYSA-N 2-(4-tert-butylphenoxy)-n-cyclooctylacetamide Chemical compound C1=CC(C(C)(C)C)=CC=C1OCC(=O)NC1CCCCCCC1 NQYUAQXLGCYCTN-UHFFFAOYSA-N 0.000 claims 1
• FYVCOFXRBWDYKD-UHFFFAOYSA-N 2-(6-oxo-6-piperidin-1-ylhexyl)isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1CCCCCC(=O)N1CCCCC1 FYVCOFXRBWDYKD-UHFFFAOYSA-N 0.000 claims 1
• RRXGONGMTCRWTG-UHFFFAOYSA-N 2-(azepan-1-yl)-n-(2-phenylphenyl)acetamide Chemical compound C=1C=CC=C(C=2C=CC=CC=2)C=1NC(=O)CN1CCCCCC1 RRXGONGMTCRWTG-UHFFFAOYSA-N 0.000 claims 1
• ZYDUOYLUMSMWPM-UHFFFAOYSA-N 2-(cyclohexylamino)-N-(2-methoxydibenzofuran-3-yl)-1,3-thiazole-4-carboxamide Chemical compound COC1=CC(C2=CC=CC=C2O2)=C2C=C1NC(=O)C(N=1)=CSC=1NC1CCCCC1 ZYDUOYLUMSMWPM-UHFFFAOYSA-N 0.000 claims 1
• HUIMOLNHHAFFEU-UHFFFAOYSA-N 2-(cyclohexylamino)-n-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,3-thiazole-4-carboxamide Chemical compound C1CCC2=CC=CC=C2C1NC(=O)C(N=1)=CSC=1NC1CCCCC1 HUIMOLNHHAFFEU-UHFFFAOYSA-N 0.000 claims 1
• MWWOAZWEEHAJJX-UHFFFAOYSA-N 2-(cyclohexylamino)-n-(1-ethynylcyclohexyl)-1,3-thiazole-4-carboxamide Chemical compound C=1SC(NC2CCCCC2)=NC=1C(=O)NC1(C#C)CCCCC1 MWWOAZWEEHAJJX-UHFFFAOYSA-N 0.000 claims 1
• RQZWWNLSUYEWOE-UHFFFAOYSA-N 2-(cyclohexylamino)-n-(3-methylbutan-2-yl)-1,3-thiazole-4-carboxamide Chemical compound CC(C)C(C)NC(=O)C1=CSC(NC2CCCCC2)=N1 RQZWWNLSUYEWOE-UHFFFAOYSA-N 0.000 claims 1
• AALJBQNYQDCDMN-UHFFFAOYSA-N 2-(cyclohexylamino)-n-(4-hydroxycyclohexyl)-1,3-thiazole-4-carboxamide Chemical compound C1CC(O)CCC1NC(=O)C1=CSC(NC2CCCCC2)=N1 AALJBQNYQDCDMN-UHFFFAOYSA-N 0.000 claims 1
• IUSJOSOPIJDCMV-UHFFFAOYSA-N 2-(cyclohexylamino)-n-[2-(4-hydroxyphenyl)ethyl]-1,3-thiazole-4-carboxamide Chemical compound C1=CC(O)=CC=C1CCNC(=O)C1=CSC(NC2CCCCC2)=N1 IUSJOSOPIJDCMV-UHFFFAOYSA-N 0.000 claims 1
• ZQMPXFCWWNKNFB-UHFFFAOYSA-N 2-(cyclohexylamino)-n-[3-(1-hydroxyethyl)phenyl]-1,3-thiazole-4-carboxamide Chemical compound CC(O)C1=CC=CC(NC(=O)C=2N=C(NC3CCCCC3)SC=2)=C1 ZQMPXFCWWNKNFB-UHFFFAOYSA-N 0.000 claims 1
• AAHJNOMSGVULMS-UHFFFAOYSA-N 2-(cyclohexylamino)-n-pentan-3-yl-1,3-thiazole-4-carboxamide Chemical compound CCC(CC)NC(=O)C1=CSC(NC2CCCCC2)=N1 AAHJNOMSGVULMS-UHFFFAOYSA-N 0.000 claims 1
• JIBDQUYVHSTHGS-UHFFFAOYSA-N 2-(diethylamino)-n-[(1-phenylcyclopentyl)methyl]propanamide Chemical compound C=1C=CC=CC=1C1(CNC(=O)C(C)N(CC)CC)CCCC1 JIBDQUYVHSTHGS-UHFFFAOYSA-N 0.000 claims 1
• CLFPZFZXHQIPLU-UHFFFAOYSA-N 2-(dimethylamino)-n-(2-nitrophenyl)benzamide Chemical compound CN(C)C1=CC=CC=C1C(=O)NC1=CC=CC=C1[N+]([O-])=O CLFPZFZXHQIPLU-UHFFFAOYSA-N 0.000 claims 1
• QMFWWRKULSMUSH-UHFFFAOYSA-N 2-(heptylcarbamoyl)bicyclo[2.2.1]hept-5-ene-3-carboxylic acid Chemical compound C1C2C=CC1C(C(=O)NCCCCCCC)C2C(O)=O QMFWWRKULSMUSH-UHFFFAOYSA-N 0.000 claims 1
• PJVLHKQTZLLMDV-UHFFFAOYSA-N 2-(hexylamino)-n-[(4-hydroxyphenyl)methyl]-n-methylacetamide Chemical compound CCCCCCNCC(=O)N(C)CC1=CC=C(O)C=C1 PJVLHKQTZLLMDV-UHFFFAOYSA-N 0.000 claims 1
• SJUHYWWBQFWWQS-UHFFFAOYSA-N 2-(piperidine-1-carbonyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile Chemical compound N=1C(C#N)=C(N2CCCCC2)OC=1C(=O)N1CCCCC1 SJUHYWWBQFWWQS-UHFFFAOYSA-N 0.000 claims 1
• DPEZMUJHPZIRQS-UHFFFAOYSA-N 2-[(2,6-difluorophenyl)methylamino]-n-[2-[3-(trifluoromethyl)phenyl]ethyl]acetamide Chemical compound FC1=CC=CC(F)=C1CNCC(=O)NCCC1=CC=CC(C(F)(F)F)=C1 DPEZMUJHPZIRQS-UHFFFAOYSA-N 0.000 claims 1
• GRCSGDXAMFCVSH-UHFFFAOYSA-N 2-[(2-amino-2-oxoethyl)-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]acetic acid Chemical compound COC1=CC(C(=O)N(CC(N)=O)CC(O)=O)=CC(C(=O)C=2N=CC=CC=2)=C1 GRCSGDXAMFCVSH-UHFFFAOYSA-N 0.000 claims 1
• ZBOQEIHWWSHQTC-UHFFFAOYSA-N 2-[(2-benzylsulfanylacetyl)-(2-methoxyethyl)amino]-n-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]ethyl]acetamide Chemical compound C=1C=CC=CC=1CSCC(=O)N(CCOC)CC(=O)NCCSCC1=C(F)C=CC=C1Cl ZBOQEIHWWSHQTC-UHFFFAOYSA-N 0.000 claims 1
• NHEHDFPGKKPRFX-UHFFFAOYSA-N 2-[(2-methylphenyl)methylsulfanyl]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC=CC=C1CSCC(=O)N1CCN(C=2C=CC=CC=2)CC1 NHEHDFPGKKPRFX-UHFFFAOYSA-N 0.000 claims 1
• ZSSONPIPZWGZFV-UHFFFAOYSA-N 2-[(3-bromophenyl)methylsulfanyl]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound BrC1=CC=CC(CSCC(=O)N2CCN(CC2)C=2C=CC=CC=2)=C1 ZSSONPIPZWGZFV-UHFFFAOYSA-N 0.000 claims 1
• OZWBTJRHLDARMF-UHFFFAOYSA-N 2-[(3-bromophenyl)methylsulfanyl]-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC=C1N1CCN(C(=O)CSCC=2C=C(Br)C=CC=2)CC1 OZWBTJRHLDARMF-UHFFFAOYSA-N 0.000 claims 1
• YUYYOUDVNNTGBH-UHFFFAOYSA-N 2-[(3-bromophenyl)methylsulfanyl]-1-piperidin-1-ylethanone Chemical compound BrC1=CC=CC(CSCC(=O)N2CCCCC2)=C1 YUYYOUDVNNTGBH-UHFFFAOYSA-N 0.000 claims 1
• NVOXEBNTRXVDSD-UHFFFAOYSA-N 2-[(3-propoxycarbonyl-5,6-dihydro-4h-cyclopenta[b]thiophen-2-yl)carbamoyl]bicyclo[2.2.1]heptane-3-carboxylic acid Chemical compound C1CCC2=C1SC(NC(=O)C1C(C3CCC1C3)C(O)=O)=C2C(=O)OCCC NVOXEBNTRXVDSD-UHFFFAOYSA-N 0.000 claims 1
• DJHQDEYOSLJOLU-UHFFFAOYSA-N 2-[(4-methylphenyl)methylsulfanyl]-1-piperidin-1-ylethanone Chemical compound C1=CC(C)=CC=C1CSCC(=O)N1CCCCC1 DJHQDEYOSLJOLU-UHFFFAOYSA-N 0.000 claims 1
• RCUQXNIZNQXWHL-UHFFFAOYSA-N 2-[(5,6-dimethyl-4-oxo-3h-thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-n-(furan-2-ylmethyl)acetamide Chemical compound N1C(=O)C=2C(C)=C(C)SC=2N=C1SCC(=O)NCC1=CC=CO1 RCUQXNIZNQXWHL-UHFFFAOYSA-N 0.000 claims 1
• UULSGYZITMMALJ-UHFFFAOYSA-N 2-[(5-phenyl-1h-imidazol-2-yl)sulfanyl]-n-(2,4,4-trimethylpentan-2-yl)acetamide Chemical compound N1C(SCC(=O)NC(C)(C)CC(C)(C)C)=NC=C1C1=CC=CC=C1 UULSGYZITMMALJ-UHFFFAOYSA-N 0.000 claims 1
• OROJQMWAAMSHCB-UHFFFAOYSA-N 2-[(6-amino-1,3-benzothiazol-2-yl)sulfanyl]-n-cyclohexylacetamide Chemical compound S1C2=CC(N)=CC=C2N=C1SCC(=O)NC1CCCCC1 OROJQMWAAMSHCB-UHFFFAOYSA-N 0.000 claims 1
• FZAXAPQYHLECOI-UHFFFAOYSA-N 2-[1-(2,6-dimethylmorpholin-4-yl)-1-oxopropan-2-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C)C(=O)N1CC(C)OC(C)C1 FZAXAPQYHLECOI-UHFFFAOYSA-N 0.000 claims 1
• SAIAGGQCMGMEIA-UHFFFAOYSA-N 2-[1-(4-chlorophenyl)sulfonylbenzimidazol-2-yl]sulfanyl-n-(thiophen-2-ylmethyl)acetamide Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)N1C2=CC=CC=C2N=C1SCC(=O)NCC1=CC=CS1 SAIAGGQCMGMEIA-UHFFFAOYSA-N 0.000 claims 1
• WHZXXYYHHHQBQY-UHFFFAOYSA-N 2-[1-(azepan-1-yl)-3-methyl-1-oxobutan-2-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C(C)C)C(=O)N1CCCCCC1 WHZXXYYHHHQBQY-UHFFFAOYSA-N 0.000 claims 1
• TVUZQZKYWYADOX-UHFFFAOYSA-N 2-[1-morpholin-4-yl-3-(4-nitrophenyl)-1-oxopropan-2-yl]isoindole-1,3-dione Chemical compound C1=CC([N+](=O)[O-])=CC=C1CC(C(=O)N1CCOCC1)N1C(=O)C2=CC=CC=C2C1=O TVUZQZKYWYADOX-UHFFFAOYSA-N 0.000 claims 1
• XDUFXJIZTFOCLG-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-2-adamantyl]-1-(4-methylpiperazin-1-yl)ethanone Chemical compound C1CN(C)CCN1C(=O)CC1(C=2C=CC(Cl)=CC=2)C(C2)CC3CC2CC1C3 XDUFXJIZTFOCLG-UHFFFAOYSA-N 0.000 claims 1
• GGKNHRRHTQJTTL-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-2-adamantyl]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)CC2(C3CC4CC(C3)CC2C4)C=2C=CC(Cl)=CC=2)CC1 GGKNHRRHTQJTTL-UHFFFAOYSA-N 0.000 claims 1
• OGOUTJBZNBTLDZ-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-2-adamantyl]-n-(2-hydroxyethyl)acetamide Chemical compound C1C2CC(C3)CC1CC3C2(CC(=O)NCCO)C1=CC=C(Cl)C=C1 OGOUTJBZNBTLDZ-UHFFFAOYSA-N 0.000 claims 1
• HPOGVCKERGTYKP-UHFFFAOYSA-N 2-[2-[[(2-amino-2-oxoethyl)-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC(N)=O)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 HPOGVCKERGTYKP-UHFFFAOYSA-N 0.000 claims 1
• LLOIADUZZZXHIZ-UHFFFAOYSA-N 2-[2-[[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-(3-methylbutyl)amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CCC(C)C)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 LLOIADUZZZXHIZ-UHFFFAOYSA-N 0.000 claims 1
• IHPWLYWFNHBBJS-UHFFFAOYSA-N 2-[2-[[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-methylamino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(C)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 IHPWLYWFNHBBJS-UHFFFAOYSA-N 0.000 claims 1
• NQGOXWWAGHYVOM-UHFFFAOYSA-N 2-[2-[[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-pyridin-4-ylamino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC=2C(=CC=CC=2)OCC(O)=O)C=2C=CN=CC=2)=CC=1C(=O)C1=CC=CC=N1 NQGOXWWAGHYVOM-UHFFFAOYSA-N 0.000 claims 1
• BAYIZJYSJMYCJL-UHFFFAOYSA-N 2-[2-[[cyclopentyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC=2C(=CC=CC=2)OCC(O)=O)C2CCCC2)=CC=1C(=O)C1=CC=CC=N1 BAYIZJYSJMYCJL-UHFFFAOYSA-N 0.000 claims 1
• SOQRFSOECBDGBK-UHFFFAOYSA-N 2-[2-[[cyclopropyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC=2C(=CC=CC=2)OCC(O)=O)C2CC2)=CC=1C(=O)C1=CC=CC=N1 SOQRFSOECBDGBK-UHFFFAOYSA-N 0.000 claims 1
• UHBRHCQVLCYCRF-UHFFFAOYSA-N 2-[2-[[cyclopropylmethyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC2CC2)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 UHBRHCQVLCYCRF-UHFFFAOYSA-N 0.000 claims 1
• QXOUJYYPDNMONW-UHFFFAOYSA-N 2-[3-(2-ethylpiperidin-1-yl)-3-oxopropyl]isoindole-1,3-dione Chemical compound CCC1CCCCN1C(=O)CCN1C(=O)C2=CC=CC=C2C1=O QXOUJYYPDNMONW-UHFFFAOYSA-N 0.000 claims 1
• MBRMOBDUCLMTMR-UHFFFAOYSA-N 2-[3-(azepane-1-carbonyl)phenyl]isoindole-1,3-dione Chemical compound C=1C=CC(N2C(C3=CC=CC=C3C2=O)=O)=CC=1C(=O)N1CCCCCC1 MBRMOBDUCLMTMR-UHFFFAOYSA-N 0.000 claims 1
• QQMOEWXYAKLKKS-UHFFFAOYSA-N 2-[3-(piperidine-1-carbonyl)phenyl]isoindole-1,3-dione Chemical compound C=1C=CC(N2C(C3=CC=CC=C3C2=O)=O)=CC=1C(=O)N1CCCCC1 QQMOEWXYAKLKKS-UHFFFAOYSA-N 0.000 claims 1
• FZHRSQSHHALACN-UHFFFAOYSA-N 2-[3-[2-(2-chloroanilino)-2-oxoethyl]-1-adamantyl]-n-(2-chlorophenyl)acetamide Chemical compound ClC1=CC=CC=C1NC(=O)CC1(CC(CC(=O)NC=2C(=CC=CC=2)Cl)(C2)C3)CC3CC2C1 FZHRSQSHHALACN-UHFFFAOYSA-N 0.000 claims 1
• WSEFWDLSBIPVAF-UHFFFAOYSA-N 2-[3-[4-(2-chlorophenyl)piperazin-1-yl]-3-oxopropyl]isoindole-1,3-dione Chemical compound ClC1=CC=CC=C1N1CCN(C(=O)CCN2C(C3=CC=CC=C3C2=O)=O)CC1 WSEFWDLSBIPVAF-UHFFFAOYSA-N 0.000 claims 1
• RHABXFNARUUWKE-UHFFFAOYSA-N 2-[3-cyano-4-(methoxymethyl)-6-methylpyridin-2-yl]sulfanylacetamide Chemical compound COCC1=CC(C)=NC(SCC(N)=O)=C1C#N RHABXFNARUUWKE-UHFFFAOYSA-N 0.000 claims 1
• GVQXUZISFDJWHR-UHFFFAOYSA-N 2-[3-imidazol-1-ylpropyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CCCN2C=NC=C2)CC(O)=O)=CC=1C(=O)C1=CC=CC=N1 GVQXUZISFDJWHR-UHFFFAOYSA-N 0.000 claims 1
• BMJFHITXZQCGRM-UHFFFAOYSA-N 2-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-n-cyclohexylacetamide Chemical compound C1CN(C=2SC3=CC=CC=C3N=2)CCN1CC(=O)NC1CCCCC1 BMJFHITXZQCGRM-UHFFFAOYSA-N 0.000 claims 1
• BLNIYEIMTLMHGY-UHFFFAOYSA-N 2-[4-(2-methylpropyl)phenyl]-n-(1-phenylethyl)propanamide Chemical compound C1=CC(CC(C)C)=CC=C1C(C)C(=O)NC(C)C1=CC=CC=C1 BLNIYEIMTLMHGY-UHFFFAOYSA-N 0.000 claims 1
• JBDYWCYCAGIOLC-UHFFFAOYSA-N 2-[4-(3,3,4-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C=C1)=CC=C1C(=O)N(C1)C2CC1C(C)C(C)(C)C2 JBDYWCYCAGIOLC-UHFFFAOYSA-N 0.000 claims 1
• ODDJKPUTMQGORL-UHFFFAOYSA-N 2-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]acetamide Chemical compound C1=C2N(CC(N)=O)C=CC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 ODDJKPUTMQGORL-UHFFFAOYSA-N 0.000 claims 1
• MQMLZZKIPVOGLT-UHFFFAOYSA-N 2-[[2-(2-phenyl-2-adamantyl)acetyl]amino]ethyl thiophene-2-carboxylate Chemical compound C=1C=CSC=1C(=O)OCCNC(=O)CC1(C2CC3CC(C2)CC1C3)C1=CC=CC=C1 MQMLZZKIPVOGLT-UHFFFAOYSA-N 0.000 claims 1
• HDFLDTVIHCSPFN-UHFFFAOYSA-N 2-[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-(2-oxoazepan-3-yl)amino]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC(O)=O)C2C(NCCCC2)=O)=CC=1C(=O)C1=CC=CC=N1 HDFLDTVIHCSPFN-UHFFFAOYSA-N 0.000 claims 1
• KBEPEFQMIXNIJJ-UHFFFAOYSA-N 2-[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-pyridin-4-ylamino]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC(O)=O)C=2C=CN=CC=2)=CC=1C(=O)C1=CC=CC=N1 KBEPEFQMIXNIJJ-UHFFFAOYSA-N 0.000 claims 1
• IXVDGRUBVVVBSB-UHFFFAOYSA-N 2-benzylsulfanyl-n-[2-(2-methoxyphenoxy)ethyl]acetamide Chemical compound COC1=CC=CC=C1OCCNC(=O)CSCC1=CC=CC=C1 IXVDGRUBVVVBSB-UHFFFAOYSA-N 0.000 claims 1
• ORKVVRTYVOGARV-UHFFFAOYSA-N 2-bromo-N-(6-tricyclo[3.2.1.02,4]octanylmethyl)benzamide Chemical compound BrC1=CC=CC=C1C(=O)NCC1C(C2C3C2)CC3C1 ORKVVRTYVOGARV-UHFFFAOYSA-N 0.000 claims 1
• DDDRVGVYZGDDCJ-UHFFFAOYSA-N 2-bromo-n-(2,4,4-trimethylpentan-2-yl)benzamide Chemical compound CC(C)(C)CC(C)(C)NC(=O)C1=CC=CC=C1Br DDDRVGVYZGDDCJ-UHFFFAOYSA-N 0.000 claims 1
• WGWNDVRLEDJPAD-UHFFFAOYSA-N 2-bromo-n-cycloheptylbenzamide Chemical compound BrC1=CC=CC=C1C(=O)NC1CCCCCC1 WGWNDVRLEDJPAD-UHFFFAOYSA-N 0.000 claims 1
• PDEAYYAQSYOTJP-UHFFFAOYSA-N 2-bromo-n-cyclohexyl-n-methylbenzamide Chemical compound C=1C=CC=C(Br)C=1C(=O)N(C)C1CCCCC1 PDEAYYAQSYOTJP-UHFFFAOYSA-N 0.000 claims 1
• KPWBSOREDPETKJ-UHFFFAOYSA-N 2-bromo-n-methyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C)C(=O)C1=CC=CC=C1Br KPWBSOREDPETKJ-UHFFFAOYSA-N 0.000 claims 1
• QFRKSSIXIDGZIO-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-(3,3,5-trimethylcyclohexyl)benzamide Chemical compound C1C(C)(C)CC(C)CC1NC(=O)C1=CC(F)=C(F)C=C1Cl QFRKSSIXIDGZIO-UHFFFAOYSA-N 0.000 claims 1
• LWDNHPDVAIHURM-UHFFFAOYSA-N 2-chloro-n-(2-cyclohexylethyl)benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCCC1CCCCC1 LWDNHPDVAIHURM-UHFFFAOYSA-N 0.000 claims 1
• JSBARNARTCXPMV-UHFFFAOYSA-N 2-chloro-n-(3,4-dimethylphenyl)benzamide Chemical compound C1=C(C)C(C)=CC=C1NC(=O)C1=CC=CC=C1Cl JSBARNARTCXPMV-UHFFFAOYSA-N 0.000 claims 1
• DXULUNDOVVEQAM-UHFFFAOYSA-N 2-chloro-n-[2-[(4-ethylbenzoyl)amino]ethyl]-n-(4-fluorophenyl)benzamide Chemical compound C1=CC(CC)=CC=C1C(=O)NCCN(C=1C=CC(F)=CC=1)C(=O)C1=CC=CC=C1Cl DXULUNDOVVEQAM-UHFFFAOYSA-N 0.000 claims 1
• KSSIYVKIKWJNNT-UHFFFAOYSA-N 2-chloro-n-[3-(trifluoromethyl)phenyl]benzamide Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C=2C(=CC=CC=2)Cl)=C1 KSSIYVKIKWJNNT-UHFFFAOYSA-N 0.000 claims 1
• GVZZYZHKWJWMDV-UHFFFAOYSA-N 2-chloro-n-cycloheptylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1CCCCCC1 GVZZYZHKWJWMDV-UHFFFAOYSA-N 0.000 claims 1
• SOFJAWFTYRLZBI-UHFFFAOYSA-N 2-chloro-n-cyclohexyl-6-fluoro-n-methylbenzamide Chemical compound FC=1C=CC=C(Cl)C=1C(=O)N(C)C1CCCCC1 SOFJAWFTYRLZBI-UHFFFAOYSA-N 0.000 claims 1
• ZIMRYTSHKDYHEH-UHFFFAOYSA-N 2-chloro-n-cyclohexyl-n-ethyl-4-nitrobenzamide Chemical compound C=1C=C([N+]([O-])=O)C=C(Cl)C=1C(=O)N(CC)C1CCCCC1 ZIMRYTSHKDYHEH-UHFFFAOYSA-N 0.000 claims 1
• RLCAWBGFEAYDNE-UHFFFAOYSA-N 2-chloro-n-cyclooctyl-4,5-difluorobenzamide Chemical compound C1=C(F)C(F)=CC(Cl)=C1C(=O)NC1CCCCCCC1 RLCAWBGFEAYDNE-UHFFFAOYSA-N 0.000 claims 1
• OEYWSNRVIODBJL-UHFFFAOYSA-N 2-chloro-n-methyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C)C(=O)C1=CC=CC=C1Cl OEYWSNRVIODBJL-UHFFFAOYSA-N 0.000 claims 1
• CHTAIYIAJKCWFE-UHFFFAOYSA-N 2-cyclohexyl-n-(2,6-dimethylphenyl)-n-(furan-2-ylmethyl)acetamide Chemical compound CC1=CC=CC(C)=C1N(C(=O)CC1CCCCC1)CC1=CC=CO1 CHTAIYIAJKCWFE-UHFFFAOYSA-N 0.000 claims 1
• SQDWNHRSJXSPSO-UHFFFAOYSA-N 2-hydroxy-4,4-dimethyl-6-oxo-n-phenylcyclohexene-1-carboxamide Chemical compound O=C1CC(C)(C)CC(O)=C1C(=O)NC1=CC=CC=C1 SQDWNHRSJXSPSO-UHFFFAOYSA-N 0.000 claims 1
• WMHJSKQIZWRPOI-UHFFFAOYSA-N 2-methoxy-n-[(1-phenylcyclopentyl)methyl]benzamide Chemical compound COC1=CC=CC=C1C(=O)NCC1(C=2C=CC=CC=2)CCCC1 WMHJSKQIZWRPOI-UHFFFAOYSA-N 0.000 claims 1
• ASUDFOJKTJLAIK-UHFFFAOYSA-N 2-methoxyethanamine Chemical compound COCCN ASUDFOJKTJLAIK-UHFFFAOYSA-N 0.000 claims 1
• XICOIUVERMHLLR-UHFFFAOYSA-N 2-morpholin-4-yl-n-[(1-phenylcyclopentyl)methyl]acetamide Chemical compound C1CCCC1(C=1C=CC=CC=1)CNC(=O)CN1CCOCC1 XICOIUVERMHLLR-UHFFFAOYSA-N 0.000 claims 1
• CIMNDLLQVWHXSU-UHFFFAOYSA-N 2-morpholin-4-yl-n-[(1-phenylcyclopentyl)methyl]propanamide Chemical compound C1CCCC1(C=1C=CC=CC=1)CNC(=O)C(C)N1CCOCC1 CIMNDLLQVWHXSU-UHFFFAOYSA-N 0.000 claims 1
• YTSYVPITBGXZGX-UHFFFAOYSA-N 2-phenoxy-1-[4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]ethanone Chemical compound FC(F)(F)C1=CC=CC=C1CN1CCN(C(=O)COC=2C=CC=CC=2)CC1 YTSYVPITBGXZGX-UHFFFAOYSA-N 0.000 claims 1
• AOAAKPKESCSLKH-UHFFFAOYSA-N 2-phenyl-1-(3-phenylpyrrolidin-1-yl)ethanone Chemical compound C1CC(C=2C=CC=CC=2)CN1C(=O)CC1=CC=CC=C1 AOAAKPKESCSLKH-UHFFFAOYSA-N 0.000 claims 1
• AFHVHPLKUVOZQH-UHFFFAOYSA-N 2-phenyl-n-[2-(trifluoromethyl)phenyl]butanamide Chemical compound C=1C=CC=CC=1C(CC)C(=O)NC1=CC=CC=C1C(F)(F)F AFHVHPLKUVOZQH-UHFFFAOYSA-N 0.000 claims 1
• QUQKAXPIRYDMHC-UHFFFAOYSA-N 3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl(phenyl)methanone Chemical compound C1CCC2CCCCC2N1C(=O)C1=CC=CC=C1 QUQKAXPIRYDMHC-UHFFFAOYSA-N 0.000 claims 1
• JALSUCQBKFICGJ-UHFFFAOYSA-N 3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl-[1-(4-chlorophenyl)sulfonylpiperidin-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)N1CC(C(=O)N2C3CCCCC3CCC2)CCC1 JALSUCQBKFICGJ-UHFFFAOYSA-N 0.000 claims 1
• GFAMNPSIKLWQFG-UHFFFAOYSA-N 3,4,4a,8a-tetrahydro-2h-quinolin-1-yl-(4-fluorophenyl)methanone Chemical compound C1=CC(F)=CC=C1C(=O)N1C2C=CC=CC2CCC1 GFAMNPSIKLWQFG-UHFFFAOYSA-N 0.000 claims 1
• JIQMXQBHAQRZIC-UHFFFAOYSA-N 3,4,5-trimethoxy-n-[(4-methylphenyl)methyl]-n-[6-(pyridin-2-ylamino)hexyl]benzamide Chemical compound COC1=C(OC)C(OC)=CC(C(=O)N(CCCCCCNC=2N=CC=CC=2)CC=2C=CC(C)=CC=2)=C1 JIQMXQBHAQRZIC-UHFFFAOYSA-N 0.000 claims 1
• HFYZIIYHIGTAII-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-(2-methylphenyl)methanone Chemical compound CC1=CC=CC=C1C(=O)N1CC2=CC=CC=C2CC1 HFYZIIYHIGTAII-UHFFFAOYSA-N 0.000 claims 1
• PXRUDTKTGZDJHY-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-(3,4-dimethylphenyl)methanone Chemical compound C1=C(C)C(C)=CC=C1C(=O)N1CC2=CC=CC=C2CC1 PXRUDTKTGZDJHY-UHFFFAOYSA-N 0.000 claims 1
• WSDAQQKBGUZLQI-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[1-(2-nitrophenyl)sulfonylpiperidin-3-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC=C1S(=O)(=O)N1CC(C(=O)N2CC3=CC=CC=C3CC2)CCC1 WSDAQQKBGUZLQI-UHFFFAOYSA-N 0.000 claims 1
• OSQDCCVNPHTASZ-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[3-(dimethylamino)phenyl]methanone Chemical compound CN(C)C1=CC=CC(C(=O)N2CC3=CC=CC=C3CC2)=C1 OSQDCCVNPHTASZ-UHFFFAOYSA-N 0.000 claims 1
• MCHZXTCMFSCBDH-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(1-thiophen-2-ylsulfonylpiperidin-4-yl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(CC1)CCN1S(=O)(=O)C1=CC=CS1 MCHZXTCMFSCBDH-UHFFFAOYSA-N 0.000 claims 1
• ISSLGPYALULXJH-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(2-fluorophenyl)methanone Chemical compound FC1=CC=CC=C1C(=O)N1C2=CC=CC=C2CCC1 ISSLGPYALULXJH-UHFFFAOYSA-N 0.000 claims 1
• SRCUDAZOLJXOLJ-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(2-methylphenyl)methanone Chemical compound CC1=CC=CC=C1C(=O)N1C2=CC=CC=C2CCC1 SRCUDAZOLJXOLJ-UHFFFAOYSA-N 0.000 claims 1
• ZVZWIRBGKZERRU-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(3-iodophenyl)methanone Chemical compound IC1=CC=CC(C(=O)N2C3=CC=CC=C3CCC2)=C1 ZVZWIRBGKZERRU-UHFFFAOYSA-N 0.000 claims 1
• BUTVSAACRCEEOE-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(3-piperidin-1-ylsulfonylphenyl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(C=1)=CC=CC=1S(=O)(=O)N1CCCCC1 BUTVSAACRCEEOE-UHFFFAOYSA-N 0.000 claims 1
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• XJQOINKSTXAMSQ-UHFFFAOYSA-N azepan-1-yl-(5-tert-butyl-1h-pyrazol-3-yl)methanone Chemical compound N1N=C(C(C)(C)C)C=C1C(=O)N1CCCCCC1 XJQOINKSTXAMSQ-UHFFFAOYSA-N 0.000 claims 1
• MFUXQBMFODKYNP-UHFFFAOYSA-N azepan-1-yl-[3-[(4-ethoxyphenoxy)methyl]phenyl]methanone Chemical compound C1=CC(OCC)=CC=C1OCC1=CC=CC(C(=O)N2CCCCCC2)=C1 MFUXQBMFODKYNP-UHFFFAOYSA-N 0.000 claims 1
• QTRSDGZQQMQYJB-UHFFFAOYSA-N azepan-1-yl-[4-(3,4-dihydro-1h-isoquinolin-2-ylmethyl)phenyl]methanone Chemical compound C=1C=C(CN2CC3=CC=CC=C3CC2)C=CC=1C(=O)N1CCCCCC1 QTRSDGZQQMQYJB-UHFFFAOYSA-N 0.000 claims 1
• UOCGZVXSEBPZLV-UHFFFAOYSA-N azepan-1-yl-[4-(morpholin-4-ylmethyl)phenyl]methanone Chemical compound C=1C=C(CN2CCOCC2)C=CC=1C(=O)N1CCCCCC1 UOCGZVXSEBPZLV-UHFFFAOYSA-N 0.000 claims 1
• GWUIWEXADFUPMK-UHFFFAOYSA-N azepan-1-yl-[4-[(2-chlorophenoxy)methyl]phenyl]methanone Chemical compound ClC1=CC=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)C=C1 GWUIWEXADFUPMK-UHFFFAOYSA-N 0.000 claims 1
• UCPQJIKFXBCUQB-UHFFFAOYSA-N azepan-1-yl-[4-[(4-chlorophenyl)sulfanylmethyl]phenyl]methanone Chemical compound C1=CC(Cl)=CC=C1SCC1=CC=C(C(=O)N2CCCCCC2)C=C1 UCPQJIKFXBCUQB-UHFFFAOYSA-N 0.000 claims 1
• KAKWSCYOEPHRJT-UHFFFAOYSA-N azepan-1-yl-[5-[(2,4-dichlorophenoxy)methyl]furan-2-yl]methanone Chemical compound ClC1=CC(Cl)=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)O1 KAKWSCYOEPHRJT-UHFFFAOYSA-N 0.000 claims 1
• MKRVVBQAJLOUNY-UHFFFAOYSA-N azepan-1-yl-[5-[(2-chlorophenoxy)methyl]furan-2-yl]methanone Chemical compound ClC1=CC=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)O1 MKRVVBQAJLOUNY-UHFFFAOYSA-N 0.000 claims 1
• IJINABFBHKFXNV-UHFFFAOYSA-N azepan-1-yl-[5-[(2-nitrophenoxy)methyl]furan-2-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)O1 IJINABFBHKFXNV-UHFFFAOYSA-N 0.000 claims 1
• ZHJBYQGKWYMMGA-UHFFFAOYSA-N azepan-1-yl-[5-[(4-chloro-3,5-dimethylpyrazol-1-yl)methyl]furan-2-yl]methanone Chemical compound CC1=C(Cl)C(C)=NN1CC1=CC=C(C(=O)N2CCCCCC2)O1 ZHJBYQGKWYMMGA-UHFFFAOYSA-N 0.000 claims 1
• UUFHDHOBZLCKTG-UHFFFAOYSA-N azepan-1-yl-[5-[(4-chloro-5-methyl-3-nitropyrazol-1-yl)methyl]furan-2-yl]methanone Chemical compound CC1=C(Cl)C([N+]([O-])=O)=NN1CC1=CC=C(C(=O)N2CCCCCC2)O1 UUFHDHOBZLCKTG-UHFFFAOYSA-N 0.000 claims 1
• XJJYDNBMWDYVSI-UHFFFAOYSA-N azocan-1-yl-(4-tert-butylphenyl)methanone Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)N1CCCCCCC1 XJJYDNBMWDYVSI-UHFFFAOYSA-N 0.000 claims 1
• JPYQFYIEOUVJDU-UHFFFAOYSA-N beclamide Chemical compound ClCCC(=O)NCC1=CC=CC=C1 JPYQFYIEOUVJDU-UHFFFAOYSA-N 0.000 claims 1
• QLAXSXVMBJRQCP-UHFFFAOYSA-N benzyl 2-[2-[(3,4-dimethoxyphenyl)carbamoyl]piperidin-1-yl]acetate;oxalic acid Chemical compound OC(=O)C(O)=O.C1=C(OC)C(OC)=CC=C1NC(=O)C1N(CC(=O)OCC=2C=CC=CC=2)CCCC1 QLAXSXVMBJRQCP-UHFFFAOYSA-N 0.000 claims 1
• ABBZJHFBQXYTLU-UHFFFAOYSA-N but-3-enamide Chemical compound NC(=O)CC=C ABBZJHFBQXYTLU-UHFFFAOYSA-N 0.000 claims 1
• VIZHYOQUNVSIAV-UHFFFAOYSA-N butyl 2-(n-benzoyl-3-chloro-4-fluoroanilino)propanoate Chemical compound C=1C=C(F)C(Cl)=CC=1N(C(C)C(=O)OCCCC)C(=O)C1=CC=CC=C1 VIZHYOQUNVSIAV-UHFFFAOYSA-N 0.000 claims 1
• 125000005243 carbonyl alkyl group Chemical group 0.000 claims 1
• 230000006315 carbonylation Effects 0.000 claims 1
• 238000005810 carbonylation reaction Methods 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• ATSAAFXONHKPNI-UHFFFAOYSA-N chembl1409931 Chemical compound OC1=CC=CC=C1C(O1)=NN=C1SCC(=O)N1CCCCC1 ATSAAFXONHKPNI-UHFFFAOYSA-N 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 208000037765 diseases and disorders Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• LQJVHIOSGBLNRR-UHFFFAOYSA-N ethyl 1-(3-cyclopentylpropanoyl)piperidine-3-carboxylate Chemical compound C1C(C(=O)OCC)CCCN1C(=O)CCC1CCCC1 LQJVHIOSGBLNRR-UHFFFAOYSA-N 0.000 claims 1
• LXMMPYWOJVDLMJ-UHFFFAOYSA-N ethyl 1-benzoylpiperidine-2-carboxylate Chemical compound CCOC(=O)C1CCCCN1C(=O)C1=CC=CC=C1 LXMMPYWOJVDLMJ-UHFFFAOYSA-N 0.000 claims 1
• DZTAJGBADYJNRE-UHFFFAOYSA-N ethyl 2-(adamantane-1-carbonylamino)benzoate Chemical compound CCOC(=O)C1=CC=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 DZTAJGBADYJNRE-UHFFFAOYSA-N 0.000 claims 1
• VRMSQWSZMZMFFT-UHFFFAOYSA-N ethyl 2-[6-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]acetate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2C=CN(CC(=O)OCC)C2=C1 VRMSQWSZMZMFFT-UHFFFAOYSA-N 0.000 claims 1
• DXAPIMIWEMKPPC-UHFFFAOYSA-N ethyl 2-[benzyl-(4-nitrobenzoyl)amino]acetate Chemical compound C=1C=C([N+]([O-])=O)C=CC=1C(=O)N(CC(=O)OCC)CC1=CC=CC=C1 DXAPIMIWEMKPPC-UHFFFAOYSA-N 0.000 claims 1
• WXWBQJRIFVEWGT-UHFFFAOYSA-N ethyl 2-amino-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate Chemical compound CCOC(=O)C1=C(N)SC(C(=O)N2CCCCC2)=C1C WXWBQJRIFVEWGT-UHFFFAOYSA-N 0.000 claims 1
• JJLSXJUIHYRBOV-UHFFFAOYSA-N ethyl 2-amino-5-(azepane-1-carbonyl)-4-methylthiophene-3-carboxylate Chemical compound CCOC(=O)C1=C(N)SC(C(=O)N2CCCCCC2)=C1C JJLSXJUIHYRBOV-UHFFFAOYSA-N 0.000 claims 1
• ONEQTHCBJHMZHZ-UHFFFAOYSA-N ethyl 2-amino-5-(cyclohexylcarbamoyl)-4-methylthiophene-3-carboxylate Chemical compound CCOC(=O)C1=C(N)SC(C(=O)NC2CCCCC2)=C1C ONEQTHCBJHMZHZ-UHFFFAOYSA-N 0.000 claims 1
• XUENQTYWYCCBGX-UHFFFAOYSA-N ethyl 3-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]propanoate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2N(CCC(=O)OCC)C=CC2=C1 XUENQTYWYCCBGX-UHFFFAOYSA-N 0.000 claims 1
• ZPVCURRGCDGYLA-UHFFFAOYSA-N ethyl 3-[[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carbonyl]amino]propanoate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)NCCC(=O)OCC)C2=C1 ZPVCURRGCDGYLA-UHFFFAOYSA-N 0.000 claims 1
• APSWRCMFDKPCOL-UHFFFAOYSA-N ethyl 4-[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1NC(=O)C1=CC(OC)=CC(C(=O)C=2N=CC=CC=2)=C1 APSWRCMFDKPCOL-UHFFFAOYSA-N 0.000 claims 1
• OOGKAPKQWNTMBG-UHFFFAOYSA-N ethyl 5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxylate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)OCC)C2=C1 OOGKAPKQWNTMBG-UHFFFAOYSA-N 0.000 claims 1
• RKEMWDBWPAAWAK-UHFFFAOYSA-N ethyl 6-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxylate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2C(C(=O)OCC)=CNC2=C1 RKEMWDBWPAAWAK-UHFFFAOYSA-N 0.000 claims 1
• KBIJOMUAIJBJRE-UHFFFAOYSA-N furan-2-yl-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]methanone Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1CCN(C(=O)C=2OC=CC=2)CC1 KBIJOMUAIJBJRE-UHFFFAOYSA-N 0.000 claims 1
• DNJFMXHTNUVNII-UHFFFAOYSA-N imidazo[2,1-b][1,3]thiazol-6-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C2CC(C)(C)CC1(C)CN2C(=O)C1=CN(C=CS2)C2=N1 DNJFMXHTNUVNII-UHFFFAOYSA-N 0.000 claims 1
• IENZCGNHSIMFJE-UHFFFAOYSA-N indole-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2NC=CC2=C1 IENZCGNHSIMFJE-UHFFFAOYSA-N 0.000 claims 1
• KVOPAWWXZAQLDK-UHFFFAOYSA-N methyl 2-(adamantane-1-carbonylamino)-3-(1h-indol-3-yl)propanoate Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC(C(=O)OC)CC1=CNC2=CC=CC=C12 KVOPAWWXZAQLDK-UHFFFAOYSA-N 0.000 claims 1
• ZJZIVDCVOLKKFB-UHFFFAOYSA-N methyl 2-(adamantane-1-carbonylamino)-3-phenylpropanoate Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC(C(=O)OC)CC1=CC=CC=C1 ZJZIVDCVOLKKFB-UHFFFAOYSA-N 0.000 claims 1
• HJWKNMQFBNEIPC-UHFFFAOYSA-N methyl 2-[(2-methoxybenzoyl)amino]-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate Chemical compound COC(=O)C=1C(C)=C(C(=O)N2CCCCC2)SC=1NC(=O)C1=CC=CC=C1OC HJWKNMQFBNEIPC-UHFFFAOYSA-N 0.000 claims 1
• FBSJQHFZRYKPQK-UHFFFAOYSA-N methyl 2-[(3-fluorobenzoyl)amino]-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate Chemical compound COC(=O)C=1C(C)=C(C(=O)N2CCCCC2)SC=1NC(=O)C1=CC=CC(F)=C1 FBSJQHFZRYKPQK-UHFFFAOYSA-N 0.000 claims 1
• LLGCIOWMDCLFGV-UHFFFAOYSA-N methyl 2-[[3-(4-methylphenyl)adamantane-1-carbonyl]amino]propanoate Chemical compound C1C(C(=O)NC(C)C(=O)OC)(C2)CC(C3)CC1CC32C1=CC=C(C)C=C1 LLGCIOWMDCLFGV-UHFFFAOYSA-N 0.000 claims 1
• ANQMBDBYRBFSQZ-UHFFFAOYSA-N methyl 3-[6-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-benzimidazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2NC3=CC=C(C=C3N=2)C(=O)N2C3CC(CC(C)(C)C3)(C)C2)=C1 ANQMBDBYRBFSQZ-UHFFFAOYSA-N 0.000 claims 1
• ONUFFCAYSOHVIC-UHFFFAOYSA-N methyl 3-[[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]methyl]benzoate Chemical compound COC(=O)C1=CC=CC(CN2C3=CC=C(C=C3C=C2)C(=O)N2C3CC(CC(C)(C)C3)(C)C2)=C1 ONUFFCAYSOHVIC-UHFFFAOYSA-N 0.000 claims 1
• ISINGHVAECMBPX-UHFFFAOYSA-N n'-(3,7,7-trimethyl-4-bicyclo[2.2.1]heptanyl)-n-(4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)hexanediamide Chemical compound C1C(C2(C)C)CCC2(C)C1NC(=O)CCCCC(=O)NC1(C2(C)C)CCC2CC1C ISINGHVAECMBPX-UHFFFAOYSA-N 0.000 claims 1
• CBICPLYVLNSDTG-UHFFFAOYSA-N n'-(4-methylphenyl)-n-[4-(1-naphthalen-2-ylsulfonylpiperidin-3-yl)butyl]oxamide Chemical compound C1=CC(C)=CC=C1NC(=O)C(=O)NCCCCC1CN(S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CCC1 CBICPLYVLNSDTG-UHFFFAOYSA-N 0.000 claims 1
• ZWXHHXNVOCAWNY-UHFFFAOYSA-N n,4-dimethyl-n-[4-(piperidine-1-carbonyl)phenyl]benzenesulfonamide Chemical compound C=1C=C(C)C=CC=1S(=O)(=O)N(C)C(C=C1)=CC=C1C(=O)N1CCCCC1 ZWXHHXNVOCAWNY-UHFFFAOYSA-N 0.000 claims 1
• XQUPIYUNYHIPPF-UHFFFAOYSA-N n,n'-bis(2,4-difluorophenyl)-3,3-dimethylpentanediamide Chemical compound C=1C=C(F)C=C(F)C=1NC(=O)CC(C)(C)CC(=O)NC1=CC=C(F)C=C1F XQUPIYUNYHIPPF-UHFFFAOYSA-N 0.000 claims 1
• CZZLQUVWVGDTCW-UHFFFAOYSA-N n,n-dibenzyl-1h-indole-5-carboxamide Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 CZZLQUVWVGDTCW-UHFFFAOYSA-N 0.000 claims 1
• FBVXYPJHMXIEIE-UHFFFAOYSA-N n,n-dibenzyl-2-fluorobenzamide Chemical compound FC1=CC=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 FBVXYPJHMXIEIE-UHFFFAOYSA-N 0.000 claims 1
• DAKYKYJUYQRPIB-UHFFFAOYSA-N n,n-dibenzyl-3,4-dichlorobenzamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 DAKYKYJUYQRPIB-UHFFFAOYSA-N 0.000 claims 1
• LGXXIXHEOKUPTC-UHFFFAOYSA-N n,n-dibenzyl-3,4-dimethoxybenzamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 LGXXIXHEOKUPTC-UHFFFAOYSA-N 0.000 claims 1
• BSVBUMJNVPLWLP-UHFFFAOYSA-N n,n-dibenzyl-3-chloro-1-benzothiophene-2-carboxamide Chemical compound S1C2=CC=CC=C2C(Cl)=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 BSVBUMJNVPLWLP-UHFFFAOYSA-N 0.000 claims 1
• UGHSNYACOXBNJJ-UHFFFAOYSA-N n,n-dibenzyl-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 UGHSNYACOXBNJJ-UHFFFAOYSA-N 0.000 claims 1
• QOTADBAKMSZKCW-UHFFFAOYSA-N n,n-dibenzyl-5-methylfuran-2-carboxamide Chemical compound O1C(C)=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 QOTADBAKMSZKCW-UHFFFAOYSA-N 0.000 claims 1
• ASTXNWPSIPDNBE-UHFFFAOYSA-N n,n-dibenzylthiophene-2-carboxamide Chemical compound C=1C=CSC=1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 ASTXNWPSIPDNBE-UHFFFAOYSA-N 0.000 claims 1
• UDVDKLWQHCSBQO-UHFFFAOYSA-N n,n-diethyl-1-(2-nitrophenyl)piperidine-3-carboxamide Chemical compound C1C(C(=O)N(CC)CC)CCCN1C1=CC=CC=C1[N+]([O-])=O UDVDKLWQHCSBQO-UHFFFAOYSA-N 0.000 claims 1
• SAPCUOAGJIIDAQ-UHFFFAOYSA-N n,n-diethyl-1-(4-nitrophenyl)piperidine-3-carboxamide Chemical compound C1C(C(=O)N(CC)CC)CCCN1C1=CC=C([N+]([O-])=O)C=C1 SAPCUOAGJIIDAQ-UHFFFAOYSA-N 0.000 claims 1
• QKSOXXNRTPOXPG-UHFFFAOYSA-N n,n-dimethyl-2-[3-(4-nitrophenyl)-1-adamantyl]acetamide Chemical compound C1C(CC(=O)N(C)C)(C2)CC(C3)CC1CC32C1=CC=C([N+]([O-])=O)C=C1 QKSOXXNRTPOXPG-UHFFFAOYSA-N 0.000 claims 1
• SPJBYXZFFMMCEN-UHFFFAOYSA-N n,n-dimethyl-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)N(C)C)C2=C1 SPJBYXZFFMMCEN-UHFFFAOYSA-N 0.000 claims 1
• RMRZPLJAVNSFCJ-UHFFFAOYSA-N n,n-dimethyladamantane-1-carboxamide Chemical compound C1C(C2)CC3CC2CC1(C(=O)N(C)C)C3 RMRZPLJAVNSFCJ-UHFFFAOYSA-N 0.000 claims 1
• AUNFLNYQIQZFNC-UHFFFAOYSA-N n,n-dipropyl-1,3-benzodioxole-5-carboxamide Chemical compound CCCN(CCC)C(=O)C1=CC=C2OCOC2=C1 AUNFLNYQIQZFNC-UHFFFAOYSA-N 0.000 claims 1
• JCOZSOSHYHVYRW-UHFFFAOYSA-N n-(1,1-dioxothiolan-3-yl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NC1CCS(=O)(=O)C1 JCOZSOSHYHVYRW-UHFFFAOYSA-N 0.000 claims 1
• NHNAYPQCUJLMGT-UHFFFAOYSA-N n-(1,1-dioxothiolan-3-yl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC1CCS(=O)(=O)C1 NHNAYPQCUJLMGT-UHFFFAOYSA-N 0.000 claims 1
• KILTUXSBXYMWIF-UHFFFAOYSA-N n-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-benzothiophene-3-carboxamide Chemical compound C1=CC=C2C(C(NC3C4=CC=CC=C4CCC3)=O)=CSC2=C1 KILTUXSBXYMWIF-UHFFFAOYSA-N 0.000 claims 1
• HOGHZVFLOZCSQV-UHFFFAOYSA-N n-(1,3-benzodioxol-4-yl)-1-butylpyrrolidine-2-carboxamide Chemical compound CCCCN1CCCC1C(=O)NC1=CC=CC2=C1OCO2 HOGHZVFLOZCSQV-UHFFFAOYSA-N 0.000 claims 1
• HUXDABLEJAOGSF-UHFFFAOYSA-N n-(1,3-benzodioxol-5-yl)-2,4-dichlorobenzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)NC1=CC=C(OCO2)C2=C1 HUXDABLEJAOGSF-UHFFFAOYSA-N 0.000 claims 1
• VZTYFRREFGDKEM-UHFFFAOYSA-N n-(1,3-benzodioxol-5-yl)-2-chlorobenzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1=CC=C(OCO2)C2=C1 VZTYFRREFGDKEM-UHFFFAOYSA-N 0.000 claims 1
• HJRIGSNQNHOTML-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)-2-(2-cyanophenyl)sulfanylbenzamide Chemical compound C=1C=C2OCOC2=CC=1CNC(=O)C1=CC=CC=C1SC1=CC=CC=C1C#N HJRIGSNQNHOTML-UHFFFAOYSA-N 0.000 claims 1
• IHVKROPZRZOWMQ-UHFFFAOYSA-N n-(1,3-benzodioxol-5-ylmethyl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NCC1=CC=C(OCO2)C2=C1 IHVKROPZRZOWMQ-UHFFFAOYSA-N 0.000 claims 1
• WSHKKNGZOWLLMK-UHFFFAOYSA-N n-(1-adamantyl)-1-methylindole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NC1(C2)CC(C3)CC2CC3C1 WSHKKNGZOWLLMK-UHFFFAOYSA-N 0.000 claims 1
• NRCXUNFIDNZGJT-UHFFFAOYSA-N n-(1-adamantyl)-2,4-dichloro-n-ethylbenzamide Chemical compound C1C(C2)CC(C3)CC2CC13N(CC)C(=O)C1=CC=C(Cl)C=C1Cl NRCXUNFIDNZGJT-UHFFFAOYSA-N 0.000 claims 1
• FVMFGNBRCDDCPL-UHFFFAOYSA-N n-(1-adamantyl)-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound S1C(C)=NC(C)=C1C(=O)NC1(C2)CC(C3)CC2CC3C1 FVMFGNBRCDDCPL-UHFFFAOYSA-N 0.000 claims 1
• UHFLHKZQPYROIV-UHFFFAOYSA-N n-(1-adamantyl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)CSC1=NN=NN1C1=CC=CC=C1 UHFLHKZQPYROIV-UHFFFAOYSA-N 0.000 claims 1
• HGMLRIMTBLSJIM-UHFFFAOYSA-N n-(1-adamantyl)-2-(2-benzoyl-5-methoxyphenoxy)acetamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)COC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 HGMLRIMTBLSJIM-UHFFFAOYSA-N 0.000 claims 1
• XDQJJNMHGMKEDR-UHFFFAOYSA-N n-(1-adamantyl)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)CN(C(C1)=O)CC1C1=CC=CC=C1 XDQJJNMHGMKEDR-UHFFFAOYSA-N 0.000 claims 1
• TUBPJPGLVPBAOX-UHFFFAOYSA-N n-(1-adamantyl)-2-(3-methoxyphenoxy)acetamide Chemical compound COC1=CC=CC(OCC(=O)NC23CC4CC(CC(C4)C2)C3)=C1 TUBPJPGLVPBAOX-UHFFFAOYSA-N 0.000 claims 1
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• HQCLGXUJYCTEKD-UHFFFAOYSA-N n-(3,4-dihydro-1h-isochromen-1-ylmethyl)-3-(4-hydroxyphenyl)-3-phenylpropanamide Chemical compound C1=CC(O)=CC=C1C(C=1C=CC=CC=1)CC(=O)NCC1C2=CC=CC=C2CCO1 HQCLGXUJYCTEKD-UHFFFAOYSA-N 0.000 claims 1
• PWHPQQRQNNXSMH-UHFFFAOYSA-N n-(3,4-dimethylphenyl)-n-[[4-(piperidine-1-carbonyl)phenyl]methyl]methanesulfonamide Chemical compound C1=C(C)C(C)=CC=C1N(S(C)(=O)=O)CC1=CC=C(C(=O)N2CCCCC2)C=C1 PWHPQQRQNNXSMH-UHFFFAOYSA-N 0.000 claims 1
• RORYGMMLGCGOON-UHFFFAOYSA-N n-(3-amino-2,2-dimethylpropyl)-4-[2-(2-propan-2-ylphenyl)sulfanylethyl]benzamide Chemical compound CC(C)C1=CC=CC=C1SCCC1=CC=C(C(=O)NCC(C)(C)CN)C=C1 RORYGMMLGCGOON-UHFFFAOYSA-N 0.000 claims 1
• GTHDKSMWRJXYEF-UHFFFAOYSA-N n-(3-amino-2,2-dimethylpropyl)-4-[[4-(4-chlorophenyl)pyrimidin-2-yl]sulfanylmethyl]-3-nitrobenzamide Chemical compound [O-][N+](=O)C1=CC(C(=O)NCC(C)(CN)C)=CC=C1CSC1=NC=CC(C=2C=CC(Cl)=CC=2)=N1 GTHDKSMWRJXYEF-UHFFFAOYSA-N 0.000 claims 1
• HELQBMYAEWFTJQ-UHFFFAOYSA-N n-(3-amino-2,2-dimethylpropyl)-6-(2-bromophenyl)sulfanylhexanamide Chemical compound NCC(C)(C)CNC(=O)CCCCCSC1=CC=CC=C1Br HELQBMYAEWFTJQ-UHFFFAOYSA-N 0.000 claims 1
• MZHYRSJOERZVSR-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide Chemical compound C1OC2=CC=CC=C2OC1C(=O)NC1C(C2)CCC2C1 MZHYRSJOERZVSR-UHFFFAOYSA-N 0.000 claims 1
• SVRBVAGZOMOUJS-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-2-[(2-chlorophenyl)methylsulfanyl]acetamide Chemical compound ClC1=CC=CC=C1CSCC(=O)NC1C(C2)CCC2C1 SVRBVAGZOMOUJS-UHFFFAOYSA-N 0.000 claims 1
• VLNNNESZIBWEHH-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-2-chlorobenzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C(C2)CCC2C1 VLNNNESZIBWEHH-UHFFFAOYSA-N 0.000 claims 1
• OIPPNLNOXRYSAK-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-3-cyclopentylpropanamide Chemical compound C1C(C2)CCC2C1NC(=O)CCC1CCCC1 OIPPNLNOXRYSAK-UHFFFAOYSA-N 0.000 claims 1
• KBGVBELNPALBJS-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-3-phenylsulfanylpropanamide Chemical compound C1C(C2)CCC2C1NC(=O)CCSC1=CC=CC=C1 KBGVBELNPALBJS-UHFFFAOYSA-N 0.000 claims 1
• FFZYPUYWTIIDEL-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-4-(morpholin-4-ylmethyl)benzamide Chemical compound C1C(C2)CCC2C1NC(=O)C(C=C1)=CC=C1CN1CCOCC1 FFZYPUYWTIIDEL-UHFFFAOYSA-N 0.000 claims 1
• LJWYXYYTYFGGNP-UHFFFAOYSA-N n-(3-chloro-4-hydroxyphenyl)-2-(cyclohexylamino)-1,3-thiazole-4-carboxamide Chemical compound C1=C(Cl)C(O)=CC=C1NC(=O)C1=CSC(NC2CCCCC2)=N1 LJWYXYYTYFGGNP-UHFFFAOYSA-N 0.000 claims 1
• QDQDCZORMCIXHY-UHFFFAOYSA-N n-(3-chlorophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide Chemical compound ClC1=CC=CC(NC(=O)C2CC(=O)N(C3CCCCC3)C2)=C1 QDQDCZORMCIXHY-UHFFFAOYSA-N 0.000 claims 1
• GTIYDDYACYJWJM-UHFFFAOYSA-N n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide Chemical compound S1C=2CCCCC=2C(C#N)=C1NC(=O)C(CC1=O)CN1C1CCCCC1 GTIYDDYACYJWJM-UHFFFAOYSA-N 0.000 claims 1
• PFNLHNUAHGURMS-UHFFFAOYSA-N n-(3-ethoxypropyl)-n-[(4-hydroxyphenyl)methyl]heptanamide Chemical compound CCCCCCC(=O)N(CCCOCC)CC1=CC=C(O)C=C1 PFNLHNUAHGURMS-UHFFFAOYSA-N 0.000 claims 1
• NDBGMPBQTHIHGD-UHFFFAOYSA-N n-(3-hexylsulfanyl-1,2,4-thiadiazol-5-yl)-3-methylbutanamide Chemical compound CCCCCCSC1=NSC(NC(=O)CC(C)C)=N1 NDBGMPBQTHIHGD-UHFFFAOYSA-N 0.000 claims 1
• LAMZCIPJVZGTTN-UHFFFAOYSA-N n-(3-hydroxy-1-adamantyl)-1-methylindole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NC1(C2)CC(O)(C3)CC2CC3C1 LAMZCIPJVZGTTN-UHFFFAOYSA-N 0.000 claims 1
• RUAIWPYLUWJCAM-UHFFFAOYSA-N n-(3-hydroxy-1-adamantyl)-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound S1C(C)=NC(C)=C1C(=O)NC1(C2)CC(O)(C3)CC2CC3C1 RUAIWPYLUWJCAM-UHFFFAOYSA-N 0.000 claims 1
• CRUANUTZEHQTOZ-UHFFFAOYSA-N n-(3-methylbutyl)-9-oxofluorene-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)C2=C1C=CC=C2C(=O)NCCC(C)C CRUANUTZEHQTOZ-UHFFFAOYSA-N 0.000 claims 1
• WEGYSVJPPLMZOS-UHFFFAOYSA-N n-(4,6-dimethyl-5-nitropyridin-3-yl)benzamide Chemical compound CC1=C([N+]([O-])=O)C(C)=NC=C1NC(=O)C1=CC=CC=C1 WEGYSVJPPLMZOS-UHFFFAOYSA-N 0.000 claims 1
• NTWLHHBGBISWLH-UHFFFAOYSA-N n-(4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)benzamide Chemical compound CC1(C)C(C2)CCC1(C)C2NC(=O)C1=CC=CC=C1 NTWLHHBGBISWLH-UHFFFAOYSA-N 0.000 claims 1
• VBZTZJLJCNOGMW-UHFFFAOYSA-N n-(4-acetylphenyl)-2-(2-phenyl-2-adamantyl)acetamide Chemical compound C1=CC(C(=O)C)=CC=C1NC(=O)CC1(C=2C=CC=CC=2)C(C2)CC3CC2CC1C3 VBZTZJLJCNOGMW-UHFFFAOYSA-N 0.000 claims 1
• JENNAGWUQURNEC-UHFFFAOYSA-N n-(4-benzoyl-1,2,5-oxadiazol-3-yl)-2-fluorobenzamide Chemical compound FC1=CC=CC=C1C(=O)NC1=NON=C1C(=O)C1=CC=CC=C1 JENNAGWUQURNEC-UHFFFAOYSA-N 0.000 claims 1
• VJEFEBDPMPLANV-UHFFFAOYSA-N n-(4-chloro-3-nitrophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide Chemical compound C1=C(Cl)C([N+](=O)[O-])=CC(NC(=O)C2CC(=O)N(C3CCCCC3)C2)=C1 VJEFEBDPMPLANV-UHFFFAOYSA-N 0.000 claims 1
• RHPCGRREGQKELF-UHFFFAOYSA-N n-(4-ethoxy-1,3-benzothiazol-2-yl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC(S1)=NC2=C1C=CC=C2OCC RHPCGRREGQKELF-UHFFFAOYSA-N 0.000 claims 1
• IXQRMCPUOBSRCG-UHFFFAOYSA-N n-(4-methoxyphenyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1=CC(OC)=CC=C1NC(=O)C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 IXQRMCPUOBSRCG-UHFFFAOYSA-N 0.000 claims 1
• UWZJMCNFDLBYDY-UHFFFAOYSA-N n-(4-tert-butyl-3-nitrophenyl)acetamide Chemical compound CC(=O)NC1=CC=C(C(C)(C)C)C([N+]([O-])=O)=C1 UWZJMCNFDLBYDY-UHFFFAOYSA-N 0.000 claims 1
• JDKWQEOMIREADG-UHFFFAOYSA-N n-(5-benzoyl-4-phenyl-1,3-thiazol-2-yl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC(S1)=NC(C=2C=CC=CC=2)=C1C(=O)C1=CC=CC=C1 JDKWQEOMIREADG-UHFFFAOYSA-N 0.000 claims 1
• AEKKMIRZNOZHOS-UHFFFAOYSA-N n-(5-bicyclo[2.2.1]hept-2-enylmethyl)-2,4-dichloro-n-[2-(1h-indol-3-yl)ethyl]benzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)N(CC1C2CC(C=C2)C1)CCC1=CNC2=CC=CC=C12 AEKKMIRZNOZHOS-UHFFFAOYSA-N 0.000 claims 1
• JNFUJUPCFPJNOJ-UHFFFAOYSA-N n-(5-bicyclo[2.2.1]hept-2-enylmethyl)-3-cyclopentyl-n-[2-(1h-indol-3-yl)ethyl]propanamide Chemical compound C=1NC2=CC=CC=C2C=1CCN(CC1C2CC(C=C2)C1)C(=O)CCC1CCCC1 JNFUJUPCFPJNOJ-UHFFFAOYSA-N 0.000 claims 1
• DLGNYUUYPGAJCI-UHFFFAOYSA-N n-(5-hexyl-1,3,4-thiadiazol-2-yl)-2-methylpropanamide Chemical compound CCCCCCC1=NN=C(NC(=O)C(C)C)S1 DLGNYUUYPGAJCI-UHFFFAOYSA-N 0.000 claims 1
• QBWPAMLNPUEMQM-UHFFFAOYSA-N n-(5-methylpyridin-2-yl)adamantane-1-carboxamide Chemical compound N1=CC(C)=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 QBWPAMLNPUEMQM-UHFFFAOYSA-N 0.000 claims 1
• DSLCCYVKHAKUCM-UHFFFAOYSA-N n-(6-hydroxyhexyl)-n-[(4-hydroxyphenyl)methyl]-4-propylbenzamide Chemical compound C1=CC(CCC)=CC=C1C(=O)N(CCCCCCO)CC1=CC=C(O)C=C1 DSLCCYVKHAKUCM-UHFFFAOYSA-N 0.000 claims 1
• MBDYWOZBEJJCRE-UHFFFAOYSA-N n-(7,7-dimethyl-5-oxo-6,8-dihydroquinazolin-2-yl)cyclohexanecarboxamide Chemical compound N1=C2CC(C)(C)CC(=O)C2=CN=C1NC(=O)C1CCCCC1 MBDYWOZBEJJCRE-UHFFFAOYSA-N 0.000 claims 1
• IVJKQKQWJVEAPX-UHFFFAOYSA-N n-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-1h-indole-6-carboxamide Chemical compound C1=C2C=CNC2=CC(C(=O)NC2CC3CCC(C2)N3C)=C1 IVJKQKQWJVEAPX-UHFFFAOYSA-N 0.000 claims 1
• YKTQGTHNZBBNQQ-UHFFFAOYSA-N n-(azepan-1-yl)-1-methylindole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NN1CCCCCC1 YKTQGTHNZBBNQQ-UHFFFAOYSA-N 0.000 claims 1
• ZTOMRIQLVTWRLT-UHFFFAOYSA-N n-(cyanomethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1=C2NC=C(C(=O)NCC#N)C2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 ZTOMRIQLVTWRLT-UHFFFAOYSA-N 0.000 claims 1
• PSPZLHVPXKCSTO-UHFFFAOYSA-N n-(furan-2-ylmethyl)-2-phenyl-2-phenylsulfanylacetamide Chemical compound C=1C=CC=CC=1SC(C=1C=CC=CC=1)C(=O)NCC1=CC=CO1 PSPZLHVPXKCSTO-UHFFFAOYSA-N 0.000 claims 1
• HFPHUGPYWNUHRW-UHFFFAOYSA-N n-(furan-2-ylmethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC1=CC=CO1 HFPHUGPYWNUHRW-UHFFFAOYSA-N 0.000 claims 1
• NHRXPFXVQMNCOV-UHFFFAOYSA-N n-(furan-2-ylmethyl)-n-(4-methylphenyl)adamantane-1-carboxamide Chemical compound C1=CC(C)=CC=C1N(C(=O)C12CC3CC(CC(C3)C1)C2)CC1=CC=CO1 NHRXPFXVQMNCOV-UHFFFAOYSA-N 0.000 claims 1
• WURJNPARHWUNFY-UHFFFAOYSA-N n-(naphthalen-1-ylmethyl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NCC1=CC=CC2=CC=CC=C12 WURJNPARHWUNFY-UHFFFAOYSA-N 0.000 claims 1
• DTMIDUIIAAJUOO-UHFFFAOYSA-N n-(oxolan-2-ylmethyl)-2-(2-phenylethyl)benzamide Chemical compound C=1C=CC=C(CCC=2C=CC=CC=2)C=1C(=O)NCC1CCCO1 DTMIDUIIAAJUOO-UHFFFAOYSA-N 0.000 claims 1
• RNBFYMRWWRWKHZ-UHFFFAOYSA-N n-(oxolan-2-ylmethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC1CCCO1 RNBFYMRWWRWKHZ-UHFFFAOYSA-N 0.000 claims 1
• ZTLHMUKWSKSSEP-UHFFFAOYSA-N n-(oxolan-2-ylmethyl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NCC1CCCO1 ZTLHMUKWSKSSEP-UHFFFAOYSA-N 0.000 claims 1
• OPQKNGDNBBMEDA-UHFFFAOYSA-N n-[(1,3-dioxoisoindol-2-yl)methyl]-n-(4-fluorophenyl)benzamide Chemical compound C1=CC(F)=CC=C1N(C(=O)C=1C=CC=CC=1)CN1C(=O)C2=CC=CC=C2C1=O OPQKNGDNBBMEDA-UHFFFAOYSA-N 0.000 claims 1
• VXSKXUTVJQJQAQ-UHFFFAOYSA-N n-[(1,3-dioxoisoindol-2-yl)methyl]-n-(4-hydroxyphenyl)benzamide Chemical compound C1=CC(O)=CC=C1N(C(=O)C=1C=CC=CC=1)CN1C(=O)C2=CC=CC=C2C1=O VXSKXUTVJQJQAQ-UHFFFAOYSA-N 0.000 claims 1
• GINFDOGZDWKVLS-UHFFFAOYSA-N n-[(1-methyl-2,3-dihydroindol-5-yl)methyl]-n-(oxolan-2-ylmethyl)benzamide Chemical compound C=1C=C2N(C)CCC2=CC=1CN(C(=O)C=1C=CC=CC=1)CC1CCCO1 GINFDOGZDWKVLS-UHFFFAOYSA-N 0.000 claims 1
• GHRBREPMRJCPLY-UHFFFAOYSA-N n-[(1-phenylcyclopentyl)methyl]-2-piperidin-1-ylpropanamide Chemical compound C1CCCC1(C=1C=CC=CC=1)CNC(=O)C(C)N1CCCCC1 GHRBREPMRJCPLY-UHFFFAOYSA-N 0.000 claims 1
• VAVLKSDOICPCHK-UHFFFAOYSA-N n-[(2-chlorophenyl)methyl]-n-[(4-hydroxyphenyl)methyl]-2-thiophen-2-ylacetamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CC=1SC=CC=1)CC1=CC=CC=C1Cl VAVLKSDOICPCHK-UHFFFAOYSA-N 0.000 claims 1
• FNGVCJCDXMEMAT-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-3-thiophen-3-yl-n-(2-thiophen-2-ylethyl)prop-2-enamide Chemical compound OC1=CC=CC=C1CN(C(=O)C=CC1=CSC=C1)CCC1=CC=CS1 FNGVCJCDXMEMAT-UHFFFAOYSA-N 0.000 claims 1
• GSLNTOBTTFVTSR-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-n-(2-methylpropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CC(C)C)CC1=CC=CC=C1O GSLNTOBTTFVTSR-UHFFFAOYSA-N 0.000 claims 1
• JJRQDQPXYISFOI-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-n-(3-methylbutyl)-4-propylbenzamide Chemical compound C1=CC(CCC)=CC=C1C(=O)N(CCC(C)C)CC1=CC=CC=C1O JJRQDQPXYISFOI-UHFFFAOYSA-N 0.000 claims 1
• TWJPLAKRSAQWDW-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-n-(3-methylbutyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCC(C)C)CC1=CC=CC=C1O TWJPLAKRSAQWDW-UHFFFAOYSA-N 0.000 claims 1
• USSKZFGBHIMMME-UHFFFAOYSA-N n-[(3,4-dimethoxyphenyl)methyl]-3-methoxy-n-[6-(pyridin-2-ylamino)hexyl]benzamide Chemical compound COC1=CC=CC(C(=O)N(CCCCCCNC=2N=CC=CC=2)CC=2C=C(OC)C(OC)=CC=2)=C1 USSKZFGBHIMMME-UHFFFAOYSA-N 0.000 claims 1
• QXZFEPADMBZLFG-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-2-methyl-3-nitro-n-[(4-sulfamoylphenyl)methyl]benzamide Chemical compound C1=CC=C([N+]([O-])=O)C(C)=C1C(=O)N(CC=1C=C(O)C=CC=1)CC1=CC=C(S(N)(=O)=O)C=C1 QXZFEPADMBZLFG-UHFFFAOYSA-N 0.000 claims 1
• RRTTTYAOACTRLH-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-(3-propan-2-yloxypropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCCOC(C)C)CC1=CC=CC(O)=C1 RRTTTYAOACTRLH-UHFFFAOYSA-N 0.000 claims 1
• ZEYNZPOUBJJRNL-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-(4-methylpentyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCCC(C)C)CC1=CC=CC(O)=C1 ZEYNZPOUBJJRNL-UHFFFAOYSA-N 0.000 claims 1
• NRPVGZUSINBTMC-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-[(4-propan-2-ylphenyl)methyl]heptanamide Chemical compound C=1C=CC(O)=CC=1CN(C(=O)CCCCCC)CC1=CC=C(C(C)C)C=C1 NRPVGZUSINBTMC-UHFFFAOYSA-N 0.000 claims 1
• YSZOMHNVGDQPMU-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-[2-(2-methoxyphenyl)ethyl]-2-methylpent-4-enamide Chemical compound COC1=CC=CC=C1CCN(C(=O)C(C)CC=C)CC1=CC=CC(O)=C1 YSZOMHNVGDQPMU-UHFFFAOYSA-N 0.000 claims 1
• XMRWHMWLDJUBBZ-UHFFFAOYSA-N n-[(4-bromophenyl)methyl]-n-[(4-hydroxyphenyl)methyl]-2-naphthalen-1-ylacetamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CC=1C2=CC=CC=C2C=CC=1)CC1=CC=C(Br)C=C1 XMRWHMWLDJUBBZ-UHFFFAOYSA-N 0.000 claims 1
• NBENJNKWKCXLAB-UHFFFAOYSA-N n-[(4-fluorophenyl)methyl]-n-[(4-hydroxyphenyl)methyl]-2-thiophen-3-ylacetamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CC1=CSC=C1)CC1=CC=C(F)C=C1 NBENJNKWKCXLAB-UHFFFAOYSA-N 0.000 claims 1
• VOWHPZYBTLSKGE-UHFFFAOYSA-N n-[(4-fluorophenyl)methyl]-n-[(4-hydroxyphenyl)methyl]-4-methylpentanamide Chemical compound C=1C=C(F)C=CC=1CN(C(=O)CCC(C)C)CC1=CC=C(O)C=C1 VOWHPZYBTLSKGE-UHFFFAOYSA-N 0.000 claims 1
• GFFPUGHJPPMFPR-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-6-oxo-6-phenyl-n-[[4-(trifluoromethyl)phenyl]methyl]hexanamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CCCCC(=O)C=1C=CC=CC=1)CC1=CC=C(C(F)(F)F)C=C1 GFFPUGHJPPMFPR-UHFFFAOYSA-N 0.000 claims 1
• CPFNJNJDMSVPFK-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(2-methylpropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CC(C)C)CC1=CC=C(O)C=C1 CPFNJNJDMSVPFK-UHFFFAOYSA-N 0.000 claims 1
• VQFVBRBHOPGVJQ-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(3-methylbutyl)-4-propylbenzamide Chemical compound C1=CC(CCC)=CC=C1C(=O)N(CCC(C)C)CC1=CC=C(O)C=C1 VQFVBRBHOPGVJQ-UHFFFAOYSA-N 0.000 claims 1
• ASANEODLTKPBTJ-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(3-methylbutyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCC(C)C)CC1=CC=C(O)C=C1 ASANEODLTKPBTJ-UHFFFAOYSA-N 0.000 claims 1
• ACTJJEUWBVIISW-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(3-propan-2-yloxypropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCCOC(C)C)CC1=CC=C(O)C=C1 ACTJJEUWBVIISW-UHFFFAOYSA-N 0.000 claims 1
• ASBHVXQJQYSXHO-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-[[4-(trifluoromethyl)phenyl]methyl]dec-3-enamide Chemical compound C=1C=C(C(F)(F)F)C=CC=1CN(C(=O)CC=CCCCCCC)CC1=CC=C(O)C=C1 ASBHVXQJQYSXHO-UHFFFAOYSA-N 0.000 claims 1
• OYTJXXFVCAJCET-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 OYTJXXFVCAJCET-UHFFFAOYSA-N 0.000 claims 1
• URGWKIHKPADQEK-UHFFFAOYSA-N n-[(5-hydroxy-1,3,3-trimethylcyclohexyl)methyl]-1h-indole-5-carboxamide Chemical compound C1C(C)(C)CC(O)CC1(C)CNC(=O)C1=CC=C(NC=C2)C2=C1 URGWKIHKPADQEK-UHFFFAOYSA-N 0.000 claims 1
• NTUKVZBNVAGCCU-UHFFFAOYSA-N n-[(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)methyl]-2-(4-methylphenoxy)acetamide Chemical compound C1=CC(C)=CC=C1OCC(=O)NCC1C(C2(C)C)CC2CC1 NTUKVZBNVAGCCU-UHFFFAOYSA-N 0.000 claims 1
• GPKIGQHFNOKKKG-UHFFFAOYSA-N n-[(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)methyl]-4-[2-(4-fluorophenyl)sulfanylethyl]benzamide Chemical compound CC1(C)C(CC2)CC1C2CNC(=O)C(C=C1)=CC=C1CCSC1=CC=C(F)C=C1 GPKIGQHFNOKKKG-UHFFFAOYSA-N 0.000 claims 1
• ZTMXJMHHSBJZEH-UHFFFAOYSA-N n-[(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)methyl]-4-[2-(4-phenoxypyrimidin-2-yl)sulfanylethyl]benzamide Chemical compound CC1(C)C(CC2)CC1C2CNC(=O)C(C=C1)=CC=C1CCSC(N=1)=NC=CC=1OC1=CC=CC=C1 ZTMXJMHHSBJZEH-UHFFFAOYSA-N 0.000 claims 1
• RQOMZSVTLTYBMP-UHFFFAOYSA-N n-[(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)methyl]-4-[2-[(6-methyl-1h-benzimidazol-2-yl)sulfanyl]ethyl]benzamide Chemical compound N=1C2=CC(C)=CC=C2NC=1SCCC(C=C1)=CC=C1C(=O)NCC1CCC2C(C)(C)C1C2 RQOMZSVTLTYBMP-UHFFFAOYSA-N 0.000 claims 1
• CDHCEBSOSLZVMO-UHFFFAOYSA-N n-[(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)methyl]-5-[(3-methylsulfanyl-1,2,4-thiadiazol-5-yl)sulfanyl]pentanamide Chemical compound CSC1=NSC(SCCCCC(=O)NCC2C3CC(C3(C)C)CC2)=N1 CDHCEBSOSLZVMO-UHFFFAOYSA-N 0.000 claims 1
• IBVKTCPCJMRCSA-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C1=CC=C(OCCO2)C2=C1 IBVKTCPCJMRCSA-UHFFFAOYSA-N 0.000 claims 1
• YKIPYXONFJLDLW-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-2,5-dimethylfuran-3-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C=1C=C(C)OC=1C YKIPYXONFJLDLW-UHFFFAOYSA-N 0.000 claims 1
• AMEAJMHDBTWKNQ-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-2-fluorobenzamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C1=CC=CC=C1F AMEAJMHDBTWKNQ-UHFFFAOYSA-N 0.000 claims 1
• VRSWNXIEMWQXOU-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-5-methylfuran-2-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C1=CC=C(C)O1 VRSWNXIEMWQXOU-UHFFFAOYSA-N 0.000 claims 1
• YHYIXRWFLNNBGZ-UHFFFAOYSA-N n-[1-(1h-indol-3-yl)propan-2-yl]-2-[4-(2-methylpropyl)phenyl]propanamide Chemical compound C1=CC(CC(C)C)=CC=C1C(C)C(=O)NC(C)CC1=CNC2=CC=CC=C12 YHYIXRWFLNNBGZ-UHFFFAOYSA-N 0.000 claims 1
• TZCBDOWPXZABRM-UHFFFAOYSA-N n-[1-(3-bicyclo[2.2.1]heptanyl)ethyl]-5-[(2-chlorophenoxy)methyl]furan-2-carboxamide Chemical compound C1C(C2)CCC2C1C(C)NC(=O)C(O1)=CC=C1COC1=CC=CC=C1Cl TZCBDOWPXZABRM-UHFFFAOYSA-N 0.000 claims 1
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• CNXPJWQHCFGZAE-UHFFFAOYSA-N n-[2-(2,4-dimethoxyphenyl)ethyl]adamantane-1-carboxamide Chemical compound COC1=CC(OC)=CC=C1CCNC(=O)C1(C2)CC(C3)CC2CC3C1 CNXPJWQHCFGZAE-UHFFFAOYSA-N 0.000 claims 1
• VLBKSUVJJWLCAW-UHFFFAOYSA-N n-[2-(2-bromophenyl)-1,3-benzoxazol-5-yl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)NC1=CC=C(OC(=N2)C=3C(=CC=CC=3)Br)C2=C1 VLBKSUVJJWLCAW-UHFFFAOYSA-N 0.000 claims 1
• QKZYFEVSPOZFPU-UHFFFAOYSA-N n-[2-(3,4-dimethoxyphenyl)ethyl]adamantane-1-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1CCNC(=O)C1(C2)CC(C3)CC2CC3C1 QKZYFEVSPOZFPU-UHFFFAOYSA-N 0.000 claims 1
• XAHAAWXDAQHWBU-UHFFFAOYSA-N n-[2-(4-methoxyphenyl)ethyl]adamantane-1-carboxamide Chemical compound C1=CC(OC)=CC=C1CCNC(=O)C1(C2)CC(C3)CC2CC3C1 XAHAAWXDAQHWBU-UHFFFAOYSA-N 0.000 claims 1
• BQJHVYYYKRPGIM-UHFFFAOYSA-N n-[2-(4-piperidin-1-ylsulfonylphenyl)ethyl]acetamide Chemical compound C1=CC(CCNC(=O)C)=CC=C1S(=O)(=O)N1CCCCC1 BQJHVYYYKRPGIM-UHFFFAOYSA-N 0.000 claims 1
• WRSAPVFSDCSPOJ-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-(4-ethoxyphenyl)-4-methylsulfanylbenzenesulfonamide Chemical compound C1=CC(OCC)=CC=C1N(S(=O)(=O)C=1C=CC(SC)=CC=1)CC(=O)N1CCCCCC1 WRSAPVFSDCSPOJ-UHFFFAOYSA-N 0.000 claims 1
• HITRICNKSDFOBE-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-(4-propan-2-ylphenyl)methanesulfonamide Chemical compound C1=CC(C(C)C)=CC=C1N(S(C)(=O)=O)CC(=O)N1CCCCCC1 HITRICNKSDFOBE-UHFFFAOYSA-N 0.000 claims 1
• CLBSULJBGZYOFD-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-benzyl-4-bromobenzenesulfonamide Chemical compound C1=CC(Br)=CC=C1S(=O)(=O)N(CC=1C=CC=CC=1)CC(=O)N1CCCCCC1 CLBSULJBGZYOFD-UHFFFAOYSA-N 0.000 claims 1
• GFOODFAWMIVFLW-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-benzyl-4-fluorobenzenesulfonamide Chemical compound C1=CC(F)=CC=C1S(=O)(=O)N(CC=1C=CC=CC=1)CC(=O)N1CCCCCC1 GFOODFAWMIVFLW-UHFFFAOYSA-N 0.000 claims 1
• GFCZFUKLFGZZKP-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-2-(1,3-dioxoisoindol-2-yl)propanamide Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C)C(=O)NCCC1=CCCCC1 GFCZFUKLFGZZKP-UHFFFAOYSA-N 0.000 claims 1
• YSLGNUBOLKYCJY-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-2-(2-methylphenoxy)acetamide Chemical compound CC1=CC=CC=C1OCC(=O)NCCC1=CCCCC1 YSLGNUBOLKYCJY-UHFFFAOYSA-N 0.000 claims 1
• GMNVFEWSZLMHGA-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-3-methoxybenzamide Chemical compound COC1=CC=CC(C(=O)NCCC=2CCCCC=2)=C1 GMNVFEWSZLMHGA-UHFFFAOYSA-N 0.000 claims 1
• WWZYAMAABWPOGT-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C=1SC=2CCCCC=2C=1C(=O)NCCC1=CCCCC1 WWZYAMAABWPOGT-UHFFFAOYSA-N 0.000 claims 1
• MFIKROXOKVHJEV-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-n-methyl-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)N(C)CCN(C)C)C2=C1 MFIKROXOKVHJEV-UHFFFAOYSA-N 0.000 claims 1
• DSSLCEYJQQSHEG-UHFFFAOYSA-N n-[2-(trifluoromethyl)phenyl]adamantane-1-carboxamide Chemical compound FC(F)(F)C1=CC=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 DSSLCEYJQQSHEG-UHFFFAOYSA-N 0.000 claims 1
• YNUMZAUJPFCUSI-UHFFFAOYSA-N n-[2-[1-(1,3-benzodioxol-5-yl)-3-(furan-2-yl)-3-oxopropyl]sulfanylphenyl]acetamide Chemical compound CC(=O)NC1=CC=CC=C1SC(C=1C=C2OCOC2=CC=1)CC(=O)C1=CC=CO1 YNUMZAUJPFCUSI-UHFFFAOYSA-N 0.000 claims 1
• UYCZHBLVHUBVTK-UHFFFAOYSA-N n-[2-[2-(4-bromophenyl)-2-oxoethyl]sulfanyl-1,3-benzothiazol-6-yl]acetamide Chemical compound S1C2=CC(NC(=O)C)=CC=C2N=C1SCC(=O)C1=CC=C(Br)C=C1 UYCZHBLVHUBVTK-UHFFFAOYSA-N 0.000 claims 1
• KDFZSGMYXOGMIO-UHFFFAOYSA-N n-[2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-1,3-benzothiazol-6-yl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)NC1=CC=C(N=C(SCC(=O)NC2CCCCC2)S2)C2=C1 KDFZSGMYXOGMIO-UHFFFAOYSA-N 0.000 claims 1
• BIEBTXYZDFEXFI-UHFFFAOYSA-N n-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]ethylamino]-2-oxoethyl]-4-methyl-n-prop-2-ynylcyclohexane-1-carboxamide Chemical compound C1CC(C)CCC1C(=O)N(CC#C)CC(=O)NCCSCC1=C(F)C=CC=C1Cl BIEBTXYZDFEXFI-UHFFFAOYSA-N 0.000 claims 1
• BIVUOICGADPWOS-UHFFFAOYSA-N n-[2-[4-(3,4-dihydro-1h-isoquinolin-2-ylsulfonyl)phenyl]ethyl]acetamide Chemical compound C1=CC(CCNC(=O)C)=CC=C1S(=O)(=O)N1CC2=CC=CC=C2CC1 BIVUOICGADPWOS-UHFFFAOYSA-N 0.000 claims 1
• WHIDDJNZRFQOLZ-UHFFFAOYSA-N n-[3-(1h-benzimidazol-2-ylsulfanyl)-5-nitrophenyl]adamantane-1-carboxamide Chemical compound C1=CC=C2NC(SC=3C=C(NC(=O)C45CC6CC(CC(C6)C4)C5)C=C(C=3)[N+](=O)[O-])=NC2=C1 WHIDDJNZRFQOLZ-UHFFFAOYSA-N 0.000 claims 1
• JOCWJCGOLBOXPJ-UHFFFAOYSA-N n-[3-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indol-7-yl]acetamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CNC2=C1C=CC=C2NC(=O)C JOCWJCGOLBOXPJ-UHFFFAOYSA-N 0.000 claims 1
• YOYOWAJKBHTARZ-UHFFFAOYSA-N n-[3-(4-methylpiperazin-1-yl)propyl]-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1CN(C)CCN1CCCNC(=O)C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 YOYOWAJKBHTARZ-UHFFFAOYSA-N 0.000 claims 1
• DMSAENNRNBICQZ-UHFFFAOYSA-N n-[3-(azepane-1-carbonyl)phenyl]benzamide Chemical compound C=1C=CC=CC=1C(=O)NC(C=1)=CC=CC=1C(=O)N1CCCCCC1 DMSAENNRNBICQZ-UHFFFAOYSA-N 0.000 claims 1
• FAAOHNFHEPYQPZ-UHFFFAOYSA-N n-[3-methyl-1-oxo-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)pentan-2-yl]cyclohexanecarboxamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C(C(C)CC)NC(=O)C1CCCCC1 FAAOHNFHEPYQPZ-UHFFFAOYSA-N 0.000 claims 1
• KEWGXASVBPKOLZ-UHFFFAOYSA-N n-[4-(1,3-dioxoisoindol-2-yl)butyl]-n-(4-methylphenyl)adamantane-1-carboxamide Chemical compound C1=CC(C)=CC=C1N(C(=O)C12CC3CC(CC(C3)C1)C2)CCCCN1C(=O)C2=CC=CC=C2C1=O KEWGXASVBPKOLZ-UHFFFAOYSA-N 0.000 claims 1
• NFJANHJZPRVNOA-UHFFFAOYSA-N n-[4-(1-adamantyl)-2-methylphenyl]acetamide Chemical compound C1=C(C)C(NC(=O)C)=CC=C1C1(C2)CC(C3)CC2CC3C1 NFJANHJZPRVNOA-UHFFFAOYSA-N 0.000 claims 1
• AJCBVAXPKBZVJC-UHFFFAOYSA-N n-[4-(2,5-difluorophenoxy)butyl]bicyclo[2.2.1]hept-2-ene-5-carboxamide Chemical compound FC1=CC=C(F)C(OCCCCNC(=O)C2C3CC(C=C3)C2)=C1 AJCBVAXPKBZVJC-UHFFFAOYSA-N 0.000 claims 1
• VWUJTPMAQTUBPO-UHFFFAOYSA-N n-[4-(2,6-dimethylpiperidine-1-carbonyl)phenyl]-2-naphthalen-2-yloxyacetamide Chemical compound CC1CCCC(C)N1C(=O)C(C=C1)=CC=C1NC(=O)COC1=CC=C(C=CC=C2)C2=C1 VWUJTPMAQTUBPO-UHFFFAOYSA-N 0.000 claims 1
• NCUSGHYMFPTESZ-UHFFFAOYSA-N n-[4-(2-methylpiperidin-1-yl)sulfonylphenyl]acetamide Chemical compound CC1CCCCN1S(=O)(=O)C1=CC=C(NC(C)=O)C=C1 NCUSGHYMFPTESZ-UHFFFAOYSA-N 0.000 claims 1
• JCZHIUIBWFMQAP-UHFFFAOYSA-N n-[4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C(=O)N1C(CC(C)(C)C2)CC2(C)C1 JCZHIUIBWFMQAP-UHFFFAOYSA-N 0.000 claims 1
• AAYDTRXEZOFOGV-UHFFFAOYSA-N n-[4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]thiophene-2-sulfonamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1NS(=O)(=O)C1=CC=CS1 AAYDTRXEZOFOGV-UHFFFAOYSA-N 0.000 claims 1
• SBQBHKOPZICODL-UHFFFAOYSA-N n-[4-(4-fluorophenyl)-4-hydroxybutyl]-n-propan-2-ylthiophene-2-carboxamide Chemical compound C=1C=CSC=1C(=O)N(C(C)C)CCCC(O)C1=CC=C(F)C=C1 SBQBHKOPZICODL-UHFFFAOYSA-N 0.000 claims 1
• PFBIWVZHHKAYJE-UHFFFAOYSA-N n-[4-(4-methylpiperidin-1-yl)sulfonylphenyl]furan-2-carboxamide Chemical compound C1CC(C)CCN1S(=O)(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CO1 PFBIWVZHHKAYJE-UHFFFAOYSA-N 0.000 claims 1
• PLTSFYXDNLGOQL-UHFFFAOYSA-N n-[4-(azepan-1-ylsulfonyl)phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=CC(NC(=O)C(F)(F)F)=CC=C1S(=O)(=O)N1CCCCCC1 PLTSFYXDNLGOQL-UHFFFAOYSA-N 0.000 claims 1
• BWRQBALTUPPEHN-UHFFFAOYSA-N n-[4-(azepane-1-carbonyl)phenyl]-n-methylbenzenesulfonamide Chemical compound C=1C=CC=CC=1S(=O)(=O)N(C)C(C=C1)=CC=C1C(=O)N1CCCCCC1 BWRQBALTUPPEHN-UHFFFAOYSA-N 0.000 claims 1
• ZMMXAQZVRTZPKF-UHFFFAOYSA-N n-[4-[benzyl(propan-2-yl)sulfamoyl]phenyl]acetamide Chemical compound C=1C=C(NC(C)=O)C=CC=1S(=O)(=O)N(C(C)C)CC1=CC=CC=C1 ZMMXAQZVRTZPKF-UHFFFAOYSA-N 0.000 claims 1
• IOOQRTGQTISKGP-UHFFFAOYSA-N n-[5-(5-chloro-1,3-benzoxazol-2-yl)-2-methylphenyl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)NC1=CC(C=2OC3=CC=C(Cl)C=C3N=2)=CC=C1C IOOQRTGQTISKGP-UHFFFAOYSA-N 0.000 claims 1
• FIGDPVVDJQSDSB-UHFFFAOYSA-N n-[5-[(2,4-dichlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide Chemical compound S1C(NC(=O)C(C)(C)C)=NN=C1SCC1=CC=C(Cl)C=C1Cl FIGDPVVDJQSDSB-UHFFFAOYSA-N 0.000 claims 1
• XMPPBIXEZQVXGO-UHFFFAOYSA-N n-[5-[(2-fluorophenyl)methylsulfanylmethyl]-1,3,4-thiadiazol-2-yl]cyclohexanecarboxamide Chemical compound FC1=CC=CC=C1CSCC(S1)=NN=C1NC(=O)C1CCCCC1 XMPPBIXEZQVXGO-UHFFFAOYSA-N 0.000 claims 1
• ZHKFMACOXDAWLY-UHFFFAOYSA-N n-[5-[(3,4-dichlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide Chemical compound S1C(NC(=O)C(C)(C)C)=NN=C1CC1=CC=C(Cl)C(Cl)=C1 ZHKFMACOXDAWLY-UHFFFAOYSA-N 0.000 claims 1
• JUGGVFGUZJIERO-UHFFFAOYSA-N n-[5-[(3,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-methylbutanamide Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NN=C(NC(=O)CC(C)C)S1 JUGGVFGUZJIERO-UHFFFAOYSA-N 0.000 claims 1
• JTAJDRPNOSMJDJ-UHFFFAOYSA-N n-[[2-[(4-fluorophenyl)methylamino]-1,3-thiazol-4-yl]methyl]-n-(2-phenylethyl)butanamide Chemical compound C=1SC(NCC=2C=CC(F)=CC=2)=NC=1CN(C(=O)CCC)CCC1=CC=CC=C1 JTAJDRPNOSMJDJ-UHFFFAOYSA-N 0.000 claims 1
• PEOPQRYUIQSKSG-UHFFFAOYSA-N n-[[4-(3,4-dihydro-1h-isoquinoline-2-carbonyl)phenyl]methyl]-n-(3,4-dimethylphenyl)methanesulfonamide Chemical compound C1=C(C)C(C)=CC=C1N(S(C)(=O)=O)CC1=CC=C(C(=O)N2CC3=CC=CC=C3CC2)C=C1 PEOPQRYUIQSKSG-UHFFFAOYSA-N 0.000 claims 1
• WPDJDHRXHNJFKD-UHFFFAOYSA-N n-[[4-(trifluoromethyl)phenyl]methyl]-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC1=CC=C(C(F)(F)F)C=C1 WPDJDHRXHNJFKD-UHFFFAOYSA-N 0.000 claims 1
• YFOQQGPVQCOXPU-UHFFFAOYSA-N n-benzyl-2,4-dichloro-n-(1-cyclopropylethyl)-5-methylbenzamide Chemical compound C=1C=CC=CC=1CN(C(=O)C=1C(=CC(Cl)=C(C)C=1)Cl)C(C)C1CC1 YFOQQGPVQCOXPU-UHFFFAOYSA-N 0.000 claims 1
• YTGGACXECZKQDI-UHFFFAOYSA-N n-benzyl-2,4-dichloro-n-methylbenzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)CC1=CC=CC=C1 YTGGACXECZKQDI-UHFFFAOYSA-N 0.000 claims 1
• IICRGELEDGGGDE-UHFFFAOYSA-N n-benzyl-2,4-dichloro-n-pyridin-2-ylbenzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)N(C=1N=CC=CC=1)CC1=CC=CC=C1 IICRGELEDGGGDE-UHFFFAOYSA-N 0.000 claims 1
• GODIPIVUYYDCMJ-UHFFFAOYSA-N n-benzyl-2-(4-chlorophenyl)sulfanyl-n-methylacetamide Chemical compound C=1C=C(Cl)C=CC=1SCC(=O)N(C)CC1=CC=CC=C1 GODIPIVUYYDCMJ-UHFFFAOYSA-N 0.000 claims 1
• MHAJOKPDLPBLAO-UHFFFAOYSA-N n-benzyl-2-[4,4,6-trimethyl-1-(4-methylphenyl)pyrimidin-2-yl]sulfanylacetamide Chemical compound C=1C=C(C)C=CC=1N1C(C)=CC(C)(C)N=C1SCC(=O)NCC1=CC=CC=C1 MHAJOKPDLPBLAO-UHFFFAOYSA-N 0.000 claims 1
• CGYAEGNOMBJVDQ-UHFFFAOYSA-N n-benzyl-2-bromo-n-methylbenzamide Chemical compound C=1C=CC=C(Br)C=1C(=O)N(C)CC1=CC=CC=C1 CGYAEGNOMBJVDQ-UHFFFAOYSA-N 0.000 claims 1
• NHXZKFPAKHXJDK-UHFFFAOYSA-N n-benzyl-2-bromo-n-propan-2-ylbenzamide Chemical compound C=1C=CC=C(Br)C=1C(=O)N(C(C)C)CC1=CC=CC=C1 NHXZKFPAKHXJDK-UHFFFAOYSA-N 0.000 claims 1
• KVECKGTZTGJOCH-UHFFFAOYSA-N n-benzyl-3,5-dimethyladamantane-1-carboxamide Chemical compound C1C(C)(C2)CC(C3)CC1(C)CC32C(=O)NCC1=CC=CC=C1 KVECKGTZTGJOCH-UHFFFAOYSA-N 0.000 claims 1
• INYHTXZCWGKMOL-UHFFFAOYSA-N n-benzyl-3-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)benzenesulfonamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=1)=CC=CC=1S(=O)(=O)NCC1=CC=CC=C1 INYHTXZCWGKMOL-UHFFFAOYSA-N 0.000 claims 1
• IYNGZFWYQMVNFX-UHFFFAOYSA-N n-benzyl-3-chloro-n-methyl-1-benzothiophene-2-carboxamide Chemical compound S1C2=CC=CC=C2C(Cl)=C1C(=O)N(C)CC1=CC=CC=C1 IYNGZFWYQMVNFX-UHFFFAOYSA-N 0.000 claims 1
• JJGVEPLALDHXCZ-UHFFFAOYSA-N n-benzyl-3-methyl-4-(4-methylphenyl)butanamide Chemical compound C=1C=C(C)C=CC=1CC(C)CC(=O)NCC1=CC=CC=C1 JJGVEPLALDHXCZ-UHFFFAOYSA-N 0.000 claims 1
• RGGCHKVBJKBTEF-UHFFFAOYSA-N n-benzyl-4-bromo-n-ethylbenzamide Chemical compound C=1C=C(Br)C=CC=1C(=O)N(CC)CC1=CC=CC=C1 RGGCHKVBJKBTEF-UHFFFAOYSA-N 0.000 claims 1
• NGZSJSBJVCIBDV-UHFFFAOYSA-N n-benzyl-4-chloro-3-nitro-n-propan-2-ylbenzamide Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(=O)N(C(C)C)CC1=CC=CC=C1 NGZSJSBJVCIBDV-UHFFFAOYSA-N 0.000 claims 1
• LVOYLMZXCRBAER-UHFFFAOYSA-N n-benzyl-4-chloro-n-(1-cyclopropylethenyl)benzamide Chemical compound C1=CC(Cl)=CC=C1C(=O)N(C(=C)C1CC1)CC1=CC=CC=C1 LVOYLMZXCRBAER-UHFFFAOYSA-N 0.000 claims 1
• XIDDYQJNFNIUNM-UHFFFAOYSA-N n-benzyl-4-methyl-3-nitro-n-propan-2-ylbenzamide Chemical compound C=1C=C(C)C([N+]([O-])=O)=CC=1C(=O)N(C(C)C)CC1=CC=CC=C1 XIDDYQJNFNIUNM-UHFFFAOYSA-N 0.000 claims 1
• WOIOOHBTONFDSI-UHFFFAOYSA-N n-benzyl-4-nitro-n-propan-2-ylbenzamide Chemical compound C=1C=C([N+]([O-])=O)C=CC=1C(=O)N(C(C)C)CC1=CC=CC=C1 WOIOOHBTONFDSI-UHFFFAOYSA-N 0.000 claims 1
• POKNIDHFUWCRAD-UHFFFAOYSA-N n-benzyl-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC1=CC=CC=C1 POKNIDHFUWCRAD-UHFFFAOYSA-N 0.000 claims 1
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• RNRVUZNHZGCPED-UHFFFAOYSA-N n-cyclohexyl-n-methyl-4-phenoxybenzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)N(C)C1CCCCC1 RNRVUZNHZGCPED-UHFFFAOYSA-N 0.000 claims 1
• BFQYJUFAMIDCAF-UHFFFAOYSA-N n-cyclohexyl-n-methyl-4-phenylmethoxybenzamide Chemical compound C=1C=C(OCC=2C=CC=CC=2)C=CC=1C(=O)N(C)C1CCCCC1 BFQYJUFAMIDCAF-UHFFFAOYSA-N 0.000 claims 1
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