|
CA2478156C
(en)
|
2002-03-26 |
2011-02-15 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
ATE482747T1
(de)
*
|
2003-04-11 |
2010-10-15 |
High Point Pharmaceuticals Llc |
Neue amide derivate und deren pharmazeutische verwendungen
|
|
SE0301232D0
(sv)
*
|
2003-04-25 |
2003-04-25 |
Astrazeneca Ab |
Novel use
|
|
UY28526A1
(es)
|
2003-09-24 |
2005-04-29 |
Boehringer Ingelheim Pharma |
Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
|
|
WO2005090320A2
(en)
*
|
2004-03-12 |
2005-09-29 |
Wyeth |
Triazole derivatives and method of using the same to treat hiv infections
|
|
US7795272B2
(en)
|
2004-03-13 |
2010-09-14 |
Boehringer Ingelheim Pharmaceutical, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
|
|
AU2005240784C1
(en)
|
2004-05-07 |
2011-12-22 |
Janssen Pharmaceutica N.V. |
Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
|
|
JP2008510726A
(ja)
*
|
2004-08-20 |
2008-04-10 |
エントレメッド インコーポレイテッド |
プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
|
|
DE602005017159D1
(de)
|
2004-08-30 |
2009-11-26 |
Janssen Pharmaceutica Nv |
Oxysteroid-dehydrogenase-inhibitoren
|
|
CA2576850C
(en)
|
2004-08-30 |
2013-06-25 |
Janssen Pharmaceutica N.V. |
Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
|
|
CN101300005B
(zh)
*
|
2004-08-30 |
2013-05-01 |
詹森药业有限公司 |
作为11-β羟类固醇脱氢酶抑制剂的N-2金刚烷基-2-苯氧基-乙酰胺衍生物
|
|
EP1807080A1
(en)
*
|
2004-10-29 |
2007-07-18 |
AstraZeneca AB |
Use of unsaturated quionoline or naphtalene derivatives as medicaments
|
|
EP1817295B1
(en)
|
2004-11-18 |
2012-11-07 |
Synta Pharmaceuticals Corp. |
Triazole compounds that modulate hsp90 activity
|
|
CA2592514A1
(en)
|
2004-12-27 |
2006-07-06 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
EP1928840B1
(en)
|
2005-04-05 |
2011-08-10 |
F. Hoffmann-La Roche AG |
1H-Pyrazole-4-carboxamides, their preparation and their use as 11-beta-hydroxysteroid dehydrogenase inhibitors
|
|
KR100970294B1
(ko)
*
|
2005-06-08 |
2010-07-15 |
니뽄 다바코 산교 가부시키가이샤 |
복소환 화합물
|
|
ES2528451T3
(es)
*
|
2005-06-17 |
2015-02-10 |
Apogee Biothechnology Corporation |
Inhibidores de esfingosina cinasa
|
|
JP5118039B2
(ja)
|
2005-08-18 |
2013-01-16 |
シンタ ファーマシューティカルズ コーポレーション |
Ｈｓｐ９０活性を調節するトリアゾール化合物
|
|
US7622492B2
(en)
|
2005-08-31 |
2009-11-24 |
Hoffmann-La Roche Inc. |
Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
|
|
TW200734313A
(en)
*
|
2006-01-17 |
2007-09-16 |
Astrazeneca Ab |
Piperazines and piperidines as mGluR5 potentiators
|
|
BRPI0710479A2
(pt)
|
2006-01-18 |
2012-08-14 |
Hoffmann La Roche |
composto, processo para sua preparaÇço, composiÇço farmacÊutica, uso de um composto e mÉtodo de tratamento de doenÇa ou desosrdem metabàlica.
|
|
HUE026011T2
(en)
|
2006-03-22 |
2016-05-30 |
Hoffmann La Roche |
Pyrazoles as 11-beta-HSD-1
|
|
EP1998760A2
(en)
*
|
2006-03-30 |
2008-12-10 |
James E. Summerton |
Non peptidic molecules for detecting and treating tumors
|
|
RU2303597C1
(ru)
*
|
2006-05-12 |
2007-07-27 |
Иващенко Андрей Александрович |
Фармацевтическая композиция, способы ее получения и применения
|
|
EP2038262B1
(en)
|
2006-05-25 |
2014-11-12 |
Synta Pharmaceuticals Corp. |
Triazole compounds that modulate hsp90 activity
|
|
AU2007267843B2
(en)
*
|
2006-05-25 |
2011-10-13 |
Synta Pharmaceuticals Corp. |
Method for treating proliferative disorders associated with protooncogene products
|
|
US8115005B2
(en)
|
2006-08-04 |
2012-02-14 |
Decode Genetics Ehf. |
Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation
|
|
MX2009001036A
(es)
|
2006-08-04 |
2009-04-23 |
Merz Pharma Gmbh & Co Kgaa |
Pirazolopirimidinas, proceso para su preparacion y su uso como medicina.
|
|
US7727978B2
(en)
|
2006-08-24 |
2010-06-01 |
Bristol-Myers Squibb Company |
Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
MX2009002019A
(es)
|
2006-08-24 |
2009-03-09 |
Novartis Ag |
Derivados de 2-(pirazin-2-il)-tiazol y 2-(1h-pirazol-3-il)-tiazol asi como compuestos relacionados como inhibidores de la estearoil-coa-desaturasa (scd) para el tratamiento de trastornos metabolicos, cardiovasculares, y otros.
|
|
WO2008029168A2
(en)
*
|
2006-09-08 |
2008-03-13 |
Summit Corporation Plc |
Treatment of duchenne muscular dystrophy
|
|
CA2662574A1
(en)
|
2006-09-22 |
2008-03-27 |
Novartis Ag |
Heterocyclic organic compounds
|
|
AU2007340273B2
(en)
|
2006-10-17 |
2012-08-30 |
Rutgers, The State University Of New Jersey |
N-substituted monomers and polymers
|
|
AU2007329548A1
(en)
|
2006-12-06 |
2008-06-12 |
Boehringer Ingelheim International Gmbh |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
WO2008074835A1
(en)
|
2006-12-20 |
2008-06-26 |
Novartis Ag |
2-substituted 5-membered heterocycles as scd inhibitors
|
|
WO2008101885A1
(en)
|
2007-02-23 |
2008-08-28 |
High Point Pharmaceuticals, Llc |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
EP2150526B1
(en)
|
2007-02-23 |
2017-09-20 |
vTv Therapeutics LLC |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
EP2125704A1
(en)
|
2007-02-23 |
2009-12-02 |
High Point Pharmaceuticals, LLC |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
AU2007350326A1
(en)
*
|
2007-03-30 |
2008-10-09 |
James E. Summerton |
Non-peptidic molecules for detecting and treating tumors
|
|
CA2681582C
(en)
*
|
2007-03-30 |
2015-07-14 |
Amgen Inc. |
Methods of treating bowel disorders
|
|
WO2008134035A1
(en)
*
|
2007-04-27 |
2008-11-06 |
Panacos Pharmaceuticals, Inc. |
Alpha-unsubstituted arylmethyl piperazine pyrazolo[1,5-a] pyrimidine amide derivatives
|
|
ES2423181T3
(es)
|
2007-07-17 |
2013-09-18 |
F. Hoffmann-La Roche Ag |
Inhibidores de la 11ß-hidroxiesteroide-deshidrogenasa
|
|
WO2009015067A2
(en)
*
|
2007-07-25 |
2009-01-29 |
Boehringer Ingelheim International Gmbh |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
US8119658B2
(en)
|
2007-10-01 |
2012-02-21 |
Bristol-Myers Squibb Company |
Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
|
|
FR2929851B1
(fr)
|
2008-04-09 |
2012-11-30 |
Centre Nat Rech Scient |
Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules
|
|
EP2300472B1
(en)
|
2008-06-06 |
2012-01-18 |
Boehringer Ingelheim International GmbH |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
US8536185B2
(en)
*
|
2008-09-22 |
2013-09-17 |
Cayman Chemical Company, Incorporated |
Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
|
|
WO2010033941A1
(en)
|
2008-09-22 |
2010-03-25 |
Array Biopharma Inc. |
Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
|
|
MY169791A
(en)
|
2008-10-22 |
2019-05-15 |
Array Biopharma Inc |
Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors
|
|
EP2348857B1
(en)
|
2008-10-22 |
2016-02-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
US8329914B2
(en)
|
2008-10-31 |
2012-12-11 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
US8927549B2
(en)
|
2008-11-21 |
2015-01-06 |
High Point Pharmaceuticals, Llc |
Adamantyl benzamide derivatives
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
CN102574843B
(zh)
*
|
2009-10-22 |
2015-06-17 |
法博太科制药有限公司 |
抗纤维化剂的稠环类似物
|
|
JP2013520502A
(ja)
|
2010-02-25 |
2013-06-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
|
|
EP2560640A1
(en)
|
2010-04-19 |
2013-02-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
|
|
ME03376B
(me)
|
2010-05-20 |
2020-01-20 |
Array Biopharma Inc |
Makrociklička jedinjenja kао inhibiтori trk kinaze
|
|
AU2011202542A1
(en)
*
|
2010-07-14 |
2012-02-02 |
Indian Institute Of Science |
Benzothiophene carboxamide compounds, composition and applications thereof
|
|
FR2962649B1
(fr)
*
|
2010-07-19 |
2025-10-24 |
Conservatoire Nat Arts Et Metiers |
Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
|
|
WO2012015715A1
(en)
|
2010-07-27 |
2012-02-02 |
High Point Pharmaceuticals, Llc |
Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta hsd1 modulators
|
|
SG192941A1
(en)
|
2011-02-25 |
2013-09-30 |
Merck Sharp & Dohme |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
|
CA2853799A1
(en)
|
2011-11-02 |
2013-05-10 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
|
|
JP2014534228A
(ja)
|
2011-11-02 |
2014-12-18 |
シンタ ファーマシューティカルズ コーポレーション |
白金含有剤とｈｓｐ９０阻害剤の組合せ療法
|
|
US9402831B2
(en)
|
2011-11-14 |
2016-08-02 |
Synta Pharmaceutical Corp. |
Combination therapy of HSP90 inhibitors with BRAF inhibitors
|
|
US8889730B2
(en)
|
2012-04-10 |
2014-11-18 |
Pfizer Inc. |
Indole and indazole compounds that activate AMPK
|
|
JO3407B1
(ar)
*
|
2012-05-31 |
2019-10-20 |
Eisai R&D Man Co Ltd |
مركبات رباعي هيدرو بيرازولو بيريميدين
|
|
RU2015106909A
(ru)
|
2012-08-02 |
2016-09-27 |
Мерк Шарп И Доум Корп. |
Антидиабетические трициклические соединения
|
|
US10092574B2
(en)
|
2012-09-26 |
2018-10-09 |
Valorisation-Recherche, Limited Partnership |
Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
|
|
KR20150118158A
(ko)
|
2013-02-22 |
2015-10-21 |
머크 샤프 앤드 돔 코포레이션 |
항당뇨병 비시클릭 화합물
|
|
CA2902494C
(en)
|
2013-03-13 |
2021-01-26 |
Unilever Plc |
Prolonged delivery of certain fragrance components from personal care compositions
|
|
MX352873B
(es)
|
2013-03-13 |
2017-12-13 |
Unilever Nv |
Composiciones fotoprotectoras con triciclodecano amidas.
|
|
CA2902333C
(en)
|
2013-03-13 |
2021-06-08 |
Unilever Plc |
Cosmetic compositions with tricyclodecane amides
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
EP2970177A1
(en)
|
2013-03-15 |
2016-01-20 |
Pfizer Inc. |
Indole compounds that activate ampk
|
|
CN103420931B
(zh)
*
|
2013-05-02 |
2015-07-08 |
范国煌 |
调节巨噬细胞极化并抗糖尿病的五环化合物及其应用
|
|
GB201317363D0
(en)
|
2013-10-01 |
2013-11-13 |
Eisai Ltd |
Novel compounds
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
CA2930085C
(en)
|
2013-12-09 |
2021-11-02 |
Unilever Plc |
Process of making adamantanamides
|
|
US9381171B2
(en)
|
2013-12-19 |
2016-07-05 |
Samsung Electronics Co., Ltd. |
Composition including dapsone for preventing or treating side effect of steroid in subject and use of the composition
|
|
JP2017516850A
(ja)
|
2014-05-23 |
2017-06-22 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ｊａｋ阻害剤である５−クロロ−２−ジフルオロメトキシフェニルピラゾロピリミジン化合物
|
|
KR102529578B1
(ko)
|
2014-08-29 |
2023-05-09 |
(주)아모레퍼시픽 |
신규 아다만탄 유도체 화합물
|
|
BR112017008809A2
(pt)
|
2014-11-05 |
2017-12-19 |
Flexus Biosciences Inc |
agentes imunorreguladores
|
|
UY36390A
(es)
*
|
2014-11-05 |
2016-06-01 |
Flexus Biosciences Inc |
Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
|
|
CN113354649B
(zh)
|
2014-11-16 |
2024-12-10 |
阵列生物制药公司 |
一种新的晶型
|
|
EP3368039A1
(en)
|
2015-10-26 |
2018-09-05 |
The Regents of The University of Colorado, A Body Corporate |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
CA3010615C
(en)
|
2016-01-14 |
2024-02-20 |
Beth Israel Deaconess Medical Center, Inc. |
Mast-cell modulators and uses thereof
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
FI3439662T3
(fi)
|
2016-04-04 |
2024-09-04 |
Loxo Oncology Inc |
(s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
|
|
EP3458456B1
(en)
|
2016-05-18 |
2020-11-25 |
Loxo Oncology Inc. |
Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
WO2018086531A1
(zh)
*
|
2016-11-08 |
2018-05-17 |
正大天晴药业集团股份有限公司 |
作为cccDNA抑制剂的磺酰胺类化合物
|
|
EP3548035A4
(en)
|
2016-11-30 |
2020-07-22 |
Case Western Reserve University |
COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
EP3558298B1
(en)
|
2016-12-20 |
2026-03-11 |
Merck Sharp & Dohme LLC |
Antidiabetic spirochroman compounds
|
|
JP2020514323A
(ja)
|
2017-02-06 |
2020-05-21 |
ケース ウエスタン リザーブ ユニバーシティ |
短鎖デヒドロゲナーゼ活性を調節する組成物と方法
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
WO2018187810A1
(en)
|
2017-04-07 |
2018-10-11 |
Case Western Reserve University |
Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
|
|
MX387969B
(es)
|
2017-05-22 |
2025-03-19 |
Hoffmann La Roche |
Composiciones y compuestos terapéuticos, y métodos para su uso.
|
|
KR102921276B1
(ko)
|
2018-11-21 |
2026-02-03 |
케이스 웨스턴 리저브 유니버시티 |
단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법
|
|
SG11202106304RA
(en)
|
2018-12-31 |
2021-07-29 |
Biomea Fusion Llc |
Irreversible inhibitors of menin-mll interaction
|
|
US11174263B2
(en)
|
2018-12-31 |
2021-11-16 |
Biomea Fusion, Inc. |
Inhibitors of menin-MLL interaction
|
|
US20220288033A1
(en)
*
|
2019-09-04 |
2022-09-15 |
Agency For Science, Technology And Research |
Heterocyclic compounds as modulators of beta-catenin / tcf4 interaction
|
|
EP4055011A1
(en)
*
|
2019-11-05 |
2022-09-14 |
Dermira, Inc |
Mrgprx2 antagonists and uses thereof
|
|
WO2021092240A1
(en)
|
2019-11-05 |
2021-05-14 |
Dermira, Inc. |
Mrgprx2 antagonists for the treatment of inflammatory disorders
|
|
TW202320796A
(zh)
|
2021-08-11 |
2023-06-01 |
美商拜歐米富士恩股份有限公司 |
用於糖尿病的menin-mll相互作用之共價抑制劑
|
|
US12018032B2
(en)
|
2021-08-20 |
2024-06-25 |
Biomea Fusion, Inc. |
Crystalline forms of N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide as an irreversible inhibitor of menin-MLL interaction
|
|
WO2024155710A1
(en)
|
2023-01-18 |
2024-07-25 |
Biomea Fusion, Inc. |
Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2-pyridinecarboxamide as a covalent inhibitor of menin-mll interaction
|
|
KR102863193B1
(ko)
*
|
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