JP2006522744A

JP2006522744A - グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法

グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法 Download PDF

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Publication number: JP2006522744A
Authority: JP; Japan
Prior art keywords: phenyl; alkyl; aryl; methanone; methyl
Prior art date: 2003-04-11
Legal status : Pending

Application number

JP2006504351A

Other languages

English (en)

Japanese (ja)

Other versions

JP2006522744A5 (https=

Inventor

カムペン、ギタ・カミラ・テイルガルト

アンデルセン、ヘンリク・スネ

Current Assignee

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date

2003-04-11

Filing date

2004-04-06

Publication date

2006-10-05

2004-04-06 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2006-10-05 Publication of JP2006522744A publication Critical patent/JP2006522744A/ja

2007-05-24 Publication of JP2006522744A5 publication Critical patent/JP2006522744A5/ja

Status Pending legal-status Critical Current

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229940124750 glucocorticoid receptor agonist Drugs 0.000 title claims abstract description 46
238000002648 combination therapy Methods 0.000 title claims abstract description 41
JFUAWXPBHXKZGA-IBGZPJMESA-N 4-fluoro-2-[(4r)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol Chemical compound C([C@@](O)(CC=1NC2=CN=CC=C2C=1)C(F)(F)F)C(C)(C)C1=CC(F)=CC=C1O JFUAWXPBHXKZGA-IBGZPJMESA-N 0.000 title claims abstract description 40
230000000694 effects Effects 0.000 title claims abstract description 30
238000011292 agonist therapy Methods 0.000 title claims abstract description 24
102000008645 11-beta-Hydroxysteroid Dehydrogenase Type 1 Human genes 0.000 title claims abstract description 17
108010088011 11-beta-Hydroxysteroid Dehydrogenase Type 1 Proteins 0.000 title claims abstract description 17
239000003112 inhibitor Substances 0.000 title claims abstract description 7
206010028980 Neoplasm Diseases 0.000 claims abstract description 6
201000011510 cancer Diseases 0.000 claims abstract description 6
229940044601 receptor agonist Drugs 0.000 claims abstract 3
239000000018 receptor agonist Substances 0.000 claims abstract 3
239000003470 adrenal cortex hormone Substances 0.000 claims abstract 2
RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 claims abstract 2
125000003118 aryl group Chemical group 0.000 claims description 704
125000001072 heteroaryl group Chemical group 0.000 claims description 471
-1 C 1 -C 6 alkyl Chemical group 0.000 claims description 409
125000000753 cycloalkyl group Chemical group 0.000 claims description 272
125000000217 alkyl group Chemical group 0.000 claims description 249
239000001257 hydrogen Substances 0.000 claims description 159
229910052739 hydrogen Inorganic materials 0.000 claims description 159
150000002431 hydrogen Chemical class 0.000 claims description 148
125000005129 aryl carbonyl group Chemical group 0.000 claims description 140
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 112
125000004122 cyclic group Chemical group 0.000 claims description 107
229920006395 saturated elastomer Polymers 0.000 claims description 104
125000004043 oxo group Chemical group O=* 0.000 claims description 103
229910052757 nitrogen Inorganic materials 0.000 claims description 97
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 97
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 91
125000005843 halogen group Chemical group 0.000 claims description 88
125000004093 cyano group Chemical group *C#N 0.000 claims description 85
230000003287 optical effect Effects 0.000 claims description 84
239000000203 mixture Substances 0.000 claims description 81
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 80
125000004432 carbon atom Chemical group C* 0.000 claims description 76
229910052760 oxygen Inorganic materials 0.000 claims description 72
125000004104 aryloxy group Chemical group 0.000 claims description 70
239000001301 oxygen Chemical group 0.000 claims description 68
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 63
229910052717 sulfur Chemical group 0.000 claims description 60
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 59
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 58
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 58
125000004953 trihalomethyl group Chemical group 0.000 claims description 58
239000011593 sulfur Chemical group 0.000 claims description 56
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 56
125000005842 heteroatom Chemical group 0.000 claims description 50
125000002619 bicyclic group Chemical group 0.000 claims description 47
229940126558 11β-HSD1 inhibitor Drugs 0.000 claims description 45
150000003839 salts Chemical class 0.000 claims description 43
239000002253 acid Substances 0.000 claims description 42
150000001875 compounds Chemical class 0.000 claims description 41
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 40
229940002612 prodrug Drugs 0.000 claims description 40
239000000651 prodrug Substances 0.000 claims description 40
125000003710 aryl alkyl group Chemical group 0.000 claims description 35
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 29
125000003342 alkenyl group Chemical group 0.000 claims description 26
125000004951 trihalomethoxy group Chemical group 0.000 claims description 26
125000000304 alkynyl group Chemical group 0.000 claims description 23
125000005110 aryl thio group Chemical group 0.000 claims description 19
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 18
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 16
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 14
230000002411 adverse Effects 0.000 claims description 14
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 14
239000003862 glucocorticoid Substances 0.000 claims description 13
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
201000010099 disease Diseases 0.000 claims description 11
102000003676 Glucocorticoid Receptors Human genes 0.000 claims description 10
108090000079 Glucocorticoid Receptors Proteins 0.000 claims description 10
BZVYPVRTYHVXQF-UHFFFAOYSA-N [5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(2-methylpiperidin-1-yl)methanone Chemical compound CC1CCCCN1C(=O)C1=C2N=C(C=3OC=CC=3)C=C(C(F)(F)F)N2N=C1 BZVYPVRTYHVXQF-UHFFFAOYSA-N 0.000 claims description 10
238000011282 treatment Methods 0.000 claims description 10
125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 9
125000003545 alkoxy group Chemical group 0.000 claims description 9
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 9
229960000890 hydrocortisone Drugs 0.000 claims description 9
WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims description 9
238000000034 method Methods 0.000 claims description 8
125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims description 7
125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 7
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 7
QRROROQYZZXGBJ-UHFFFAOYSA-N [5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC=CC=3)=NC2=CC=1C(=O)N1CCCCC1 QRROROQYZZXGBJ-UHFFFAOYSA-N 0.000 claims description 7
150000001721 carbon Chemical group 0.000 claims description 7
229910052799 carbon Inorganic materials 0.000 claims description 7
125000005243 carbonyl alkyl group Chemical group 0.000 claims description 7
230000003834 intracellular effect Effects 0.000 claims description 7
229940037128 systemic glucocorticoids Drugs 0.000 claims description 7
ZIHAUZPDTWGAGA-UHFFFAOYSA-N (5,7-diphenylpyrazolo[1,5-a]pyrimidin-2-yl)-(2-methylpiperidin-1-yl)methanone Chemical compound CC1CCCCN1C(=O)C1=NN2C(C=3C=CC=CC=3)=CC(C=3C=CC=CC=3)=NC2=C1 ZIHAUZPDTWGAGA-UHFFFAOYSA-N 0.000 claims description 6
125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 6
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 6
MLHZDTXTESQRTD-UHFFFAOYSA-N [5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound C1=C2N=C(C)C=C(C(F)(F)F)N2N=C1C(=O)N1CCCCC1 MLHZDTXTESQRTD-UHFFFAOYSA-N 0.000 claims description 6
CZOAFVKPCSRZOI-UHFFFAOYSA-N [5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-piperidin-1-ylmethanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3C=CC=CC=3)=NC2=C1C(=O)N1CCCCC1 CZOAFVKPCSRZOI-UHFFFAOYSA-N 0.000 claims description 6
125000004658 aryl carbonyl amino group Chemical group 0.000 claims description 6
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
HSOHBWMXECKEKV-UHFFFAOYSA-N cyclooctanamine Chemical compound NC1CCCCCCC1 HSOHBWMXECKEKV-UHFFFAOYSA-N 0.000 claims description 6
208000035475 disorder Diseases 0.000 claims description 6
KVOPAWWXZAQLDK-UHFFFAOYSA-N methyl 2-(adamantane-1-carbonylamino)-3-(1h-indol-3-yl)propanoate Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC(C(=O)OC)CC1=CNC2=CC=CC=C12 KVOPAWWXZAQLDK-UHFFFAOYSA-N 0.000 claims description 6
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims description 6
QTSHYHWZCCQNPO-UHFFFAOYSA-N n-cyclohexyl-n,5-dimethyl-7-phenylpyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=C2N=C(C)C=C(C=3C=CC=CC=3)N2N=C1C(=O)N(C)C1CCCCC1 QTSHYHWZCCQNPO-UHFFFAOYSA-N 0.000 claims description 6
125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims description 5
208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 claims description 5
208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 claims description 5
230000009286 beneficial effect Effects 0.000 claims description 5
238000002512 chemotherapy Methods 0.000 claims description 5
125000000392 cycloalkenyl group Chemical group 0.000 claims description 5
RQVNPEVSYLEJSV-UHFFFAOYSA-N (2,6-dimethylpiperidin-1-yl)-[7-(4-ethoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(OCC)=CC=C1C1=CC(C)=NC2=CC(C(=O)N3C(CCCC3C)C)=NN12 RQVNPEVSYLEJSV-UHFFFAOYSA-N 0.000 claims description 4
YODXMLSIQUVJGG-UHFFFAOYSA-N (2-chlorophenyl)-(2-methylpiperidin-1-yl)methanone Chemical compound CC1CCCCN1C(=O)C1=CC=CC=C1Cl YODXMLSIQUVJGG-UHFFFAOYSA-N 0.000 claims description 4
LYIFABCEPRQWQI-UHFFFAOYSA-N (2-methylpiperidin-1-yl)-[5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound CC1CCCCN1C(=O)C1=NN2C(C(F)(F)F)=CC(C)=NC2=C1 LYIFABCEPRQWQI-UHFFFAOYSA-N 0.000 claims description 4
JGRMHLNCOFTDRJ-UHFFFAOYSA-N (2-methylpiperidin-1-yl)-[5-naphthalen-1-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound CC1CCCCN1C(=O)C1=NN2C(C(F)(F)F)=CC(C=3C4=CC=CC=C4C=CC=3)=NC2=C1 JGRMHLNCOFTDRJ-UHFFFAOYSA-N 0.000 claims description 4
RMODZCVFVYOBED-UHFFFAOYSA-N (2-methylpiperidin-1-yl)-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound CC1CCCCN1C(=O)C1=C2N=C(C=3SC=CC=3)C=C(C(F)(F)F)N2N=C1 RMODZCVFVYOBED-UHFFFAOYSA-N 0.000 claims description 4
DMMLDRWUYKWPBU-UHFFFAOYSA-N (3,6-dibromopyrazolo[1,5-a]pyrimidin-2-yl)-piperidin-1-ylmethanone Chemical compound N=1N2C=C(Br)C=NC2=C(Br)C=1C(=O)N1CCCCC1 DMMLDRWUYKWPBU-UHFFFAOYSA-N 0.000 claims description 4
HFKCGKDMHGFQPE-UHFFFAOYSA-N (4-benzylpiperazin-1-yl)-[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CCN(CC=4C=CC=CC=4)CC3)C=NN2C(C(F)(F)F)=C1 HFKCGKDMHGFQPE-UHFFFAOYSA-N 0.000 claims description 4
KLVNDWJMPOPRQD-UHFFFAOYSA-N (4-benzylpiperazin-1-yl)-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C1C(=O)N(CC1)CCN1CC1=CC=CC=C1 KLVNDWJMPOPRQD-UHFFFAOYSA-N 0.000 claims description 4
AKRDGBGDSLJKGO-UHFFFAOYSA-N (4-chloro-3-nitrophenyl)-(2,6-dimethylpiperidin-1-yl)methanone Chemical compound CC1CCCC(C)N1C(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 AKRDGBGDSLJKGO-UHFFFAOYSA-N 0.000 claims description 4
LAEJFMXDNTZBEC-UHFFFAOYSA-N (4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl)-phenylmethanone Chemical compound C12CCCCC2C(O)(C=2C=CC=CC=2)CCN1C(=O)C1=CC=CC=C1 LAEJFMXDNTZBEC-UHFFFAOYSA-N 0.000 claims description 4
ZQKPEGVYICVUKT-UHFFFAOYSA-N (5,7-diphenylpyrazolo[1,5-a]pyrimidin-2-yl)-piperidin-1-ylmethanone Chemical compound C1=C2N=C(C=3C=CC=CC=3)C=C(C=3C=CC=CC=3)N2N=C1C(=O)N1CCCCC1 ZQKPEGVYICVUKT-UHFFFAOYSA-N 0.000 claims description 4
GLXNSQWLLDTPEB-UHFFFAOYSA-N 2,4-dichloro-n-cyclohexyl-n-(2-hydroxyethyl)benzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(CCO)C1CCCCC1 GLXNSQWLLDTPEB-UHFFFAOYSA-N 0.000 claims description 4
UKQGYHOLIRSPTK-UHFFFAOYSA-N 2-(4-chloro-3,5-dimethylphenoxy)-n-cyclohexyl-n-methylacetamide Chemical compound C=1C(C)=C(Cl)C(C)=CC=1OCC(=O)N(C)C1CCCCC1 UKQGYHOLIRSPTK-UHFFFAOYSA-N 0.000 claims description 4
QQMOEWXYAKLKKS-UHFFFAOYSA-N 2-[3-(piperidine-1-carbonyl)phenyl]isoindole-1,3-dione Chemical compound C=1C=CC(N2C(C3=CC=CC=C3C2=O)=O)=CC=1C(=O)N1CCCCC1 QQMOEWXYAKLKKS-UHFFFAOYSA-N 0.000 claims description 4
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 4
ZTLJTWNUGYFNOO-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=CC(C(=O)N3CC4=CC=CC=C4CC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CS1 ZTLJTWNUGYFNOO-UHFFFAOYSA-N 0.000 claims description 4
ZNJBJSJCYDHLOQ-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3C4=CC=CC=C4CCC3)C=NN2C(C(F)(F)F)=C1 ZNJBJSJCYDHLOQ-UHFFFAOYSA-N 0.000 claims description 4
CAIPLUDSZJCLRO-UHFFFAOYSA-N 4-fluoro-n-[4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]benzenesulfonamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1NS(=O)(=O)C1=CC=C(F)C=C1 CAIPLUDSZJCLRO-UHFFFAOYSA-N 0.000 claims description 4
YRVQVNYRNOTDSR-UHFFFAOYSA-N 5-(1,3-benzodioxol-5-yl)-n-cyclohexyl-n-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=C1C(=O)N(C)C1CCCCC1 YRVQVNYRNOTDSR-UHFFFAOYSA-N 0.000 claims description 4
YVZXXBUYNATFEK-UHFFFAOYSA-N 6-[(2,4-dichlorophenyl)carbamoyl]-3,4-dimethylcyclohex-3-ene-1-carboxylic acid Chemical compound OC(=O)C1CC(C)=C(C)CC1C(=O)NC1=CC=C(Cl)C=C1Cl YVZXXBUYNATFEK-UHFFFAOYSA-N 0.000 claims description 4
LWQLDLBVTYCLQT-UHFFFAOYSA-N [3-bromo-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(3,4-dihydro-2h-quinolin-1-yl)methanone Chemical compound N=1C2=C(Br)C(C(=O)N3C4=CC=CC=C4CCC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CO1 LWQLDLBVTYCLQT-UHFFFAOYSA-N 0.000 claims description 4
KZQKGTMCIHZZJZ-UHFFFAOYSA-N [3-bromo-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3OC=CC=3)=NC2=C(Br)C=1C(=O)N1CCCCC1 KZQKGTMCIHZZJZ-UHFFFAOYSA-N 0.000 claims description 4
RFKOCDXSTXVFMM-UHFFFAOYSA-N [4-(4-fluorophenyl)piperazin-1-yl]-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)C2=NN3C(=CC(=NC3=C2)C=2SC=CC=2)C(F)(F)F)CC1 RFKOCDXSTXVFMM-UHFFFAOYSA-N 0.000 claims description 4
OHILVJRDWLTZLQ-UHFFFAOYSA-N [5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-pyrrolidin-1-ylmethanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=C1C(=O)N1CCCC1 OHILVJRDWLTZLQ-UHFFFAOYSA-N 0.000 claims description 4
YHWWUXFNTWSSIO-UHFFFAOYSA-N [5-(4-bromophenyl)-3-chloro-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-pyrrolidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=C(Cl)C=1C(=O)N1CCCC1 YHWWUXFNTWSSIO-UHFFFAOYSA-N 0.000 claims description 4
SFUQDBQUORTYLG-UHFFFAOYSA-N [5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(2-methylpiperidin-1-yl)methanone Chemical compound CC1CCCCN1C(=O)C1=C2N=C(C=3C=CC(Br)=CC=3)C=C(C(F)(F)F)N2N=C1 SFUQDBQUORTYLG-UHFFFAOYSA-N 0.000 claims description 4
WANDXXHDRIBGLY-UHFFFAOYSA-N [5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-morpholin-4-ylmethanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=C1C(=O)N1CCOCC1 WANDXXHDRIBGLY-UHFFFAOYSA-N 0.000 claims description 4
GTFFRCRFPPNQPG-UHFFFAOYSA-N [5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-thiomorpholin-4-ylmethanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC(C(=O)N3CCSCC3)=NN2C(C(F)(F)F)=C1 GTFFRCRFPPNQPG-UHFFFAOYSA-N 0.000 claims description 4
OZGHGJFSSWPCNA-UHFFFAOYSA-N [5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-morpholin-4-ylmethanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CCOCC3)C=NN2C(C(F)(F)F)=C1 OZGHGJFSSWPCNA-UHFFFAOYSA-N 0.000 claims description 4
BLPMCYGERRNQSC-UHFFFAOYSA-N [5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-pyrrolidin-1-ylmethanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CCCC3)C=NN2C(C(F)(F)F)=C1 BLPMCYGERRNQSC-UHFFFAOYSA-N 0.000 claims description 4
YZEIHZPMIUPJRH-UHFFFAOYSA-N [5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-pyrrolidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3OC=CC=3)=NC2=CC=1C(=O)N1CCCC1 YZEIHZPMIUPJRH-UHFFFAOYSA-N 0.000 claims description 4
ALLAXDLUGQMUBZ-UHFFFAOYSA-N [5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=C2N=C(C=3OC=CC=3)C=C(C(F)(F)F)N2N=C1 ALLAXDLUGQMUBZ-UHFFFAOYSA-N 0.000 claims description 4
BRHKYYGGLQYEPB-UHFFFAOYSA-N [5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-thiomorpholin-4-ylmethanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3OC=CC=3)=NC2=C1C(=O)N1CCSCC1 BRHKYYGGLQYEPB-UHFFFAOYSA-N 0.000 claims description 4
XQCAMTPRKIYUTD-UHFFFAOYSA-N [5-naphthalen-1-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C4=CC=CC=C4C=CC=3)=NC2=CC=1C(=O)N1CCCCC1 XQCAMTPRKIYUTD-UHFFFAOYSA-N 0.000 claims description 4
QZWNXXINFABALM-UHFFFAOYSA-N adamantan-2-amine Chemical compound C1C(C2)CC3CC1C(N)C2C3 QZWNXXINFABALM-UHFFFAOYSA-N 0.000 claims description 4
125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims description 4
125000005157 alkyl carboxy group Chemical group 0.000 claims description 4
FCCISPLISCEDCP-UHFFFAOYSA-N azepan-1-yl-(5,7-diphenylpyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical compound C1=NN2C(C=3C=CC=CC=3)=CC(C=3C=CC=CC=3)=NC2=C1C(=O)N1CCCCCC1 FCCISPLISCEDCP-UHFFFAOYSA-N 0.000 claims description 4
YIXSGTRDFWXVGM-UHFFFAOYSA-N azepan-1-yl-[3-bromo-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3OC=CC=3)=NC2=C(Br)C=1C(=O)N1CCCCCC1 YIXSGTRDFWXVGM-UHFFFAOYSA-N 0.000 claims description 4
RIYNNDAOGXNYFD-UHFFFAOYSA-N azepan-1-yl-[3-chloro-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C(Cl)C=1C(=O)N1CCCCCC1 RIYNNDAOGXNYFD-UHFFFAOYSA-N 0.000 claims description 4
PBHKXCYWSZPJIT-UHFFFAOYSA-N azepan-1-yl-[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC(C(=O)N3CCCCCC3)=NN2C(C(F)(F)F)=C1 PBHKXCYWSZPJIT-UHFFFAOYSA-N 0.000 claims description 4
CJBMERVAMZMDSS-UHFFFAOYSA-N azepan-1-yl-[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CCCCCC3)C=NN2C(C(F)(F)F)=C1 CJBMERVAMZMDSS-UHFFFAOYSA-N 0.000 claims description 4
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JPYQFYIEOUVJDU-UHFFFAOYSA-N beclamide Chemical compound ClCCC(=O)NCC1=CC=CC=C1 JPYQFYIEOUVJDU-UHFFFAOYSA-N 0.000 claims description 4
239000002552 dosage form Substances 0.000 claims description 4
MJRFHDWVUOQCHI-UHFFFAOYSA-N furan-2-yl-[4-[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]piperazin-1-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC(C(=O)N3CCN(CC3)C(=O)C=3OC=CC=3)=NN2C(C(F)(F)F)=C1 MJRFHDWVUOQCHI-UHFFFAOYSA-N 0.000 claims description 4
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WHIDDJNZRFQOLZ-UHFFFAOYSA-N n-[3-(1h-benzimidazol-2-ylsulfanyl)-5-nitrophenyl]adamantane-1-carboxamide Chemical compound C1=CC=C2NC(SC=3C=C(NC(=O)C45CC6CC(CC(C6)C4)C5)C=C(C=3)[N+](=O)[O-])=NC2=C1 WHIDDJNZRFQOLZ-UHFFFAOYSA-N 0.000 claims description 4
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BUMFOISZBMNSJG-UHFFFAOYSA-N n-cyclohexyl-n-methyl-5-naphthalen-1-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=C2N=C(C=3C4=CC=CC=C4C=CC=3)C=C(C(F)(F)F)N2N=C1C(=O)N(C)C1CCCCC1 BUMFOISZBMNSJG-UHFFFAOYSA-N 0.000 claims description 4
PKDPOEUUQXIGBU-UHFFFAOYSA-N n-cyclohexyl-n-methyl-7-phenyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=C2N=C(C(F)(F)F)C=C(C=3C=CC=CC=3)N2N=C1C(=O)N(C)C1CCCCC1 PKDPOEUUQXIGBU-UHFFFAOYSA-N 0.000 claims description 4
BSBXYTGEGWLAFC-UHFFFAOYSA-N piperidin-1-yl-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C1C(=O)N1CCCCC1 BSBXYTGEGWLAFC-UHFFFAOYSA-N 0.000 claims description 4
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239000000556 agonist Substances 0.000 claims description 3
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SPQZYOCWCJJORL-UHFFFAOYSA-N (4-methylpiperazin-1-yl)-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1CN(C)CCN1C(=O)C1=NN2C(C(F)(F)F)=CC(C=3C=CC(=CC=3)[N+]([O-])=O)=NC2=C1 SPQZYOCWCJJORL-UHFFFAOYSA-N 0.000 claims description 2
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HVMDTGSDSRRYTQ-UHFFFAOYSA-N (7-hydroxy-3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl)-phenylmethanone Chemical compound C12CC(O)CCC2CCCN1C(=O)C1=CC=CC=C1 HVMDTGSDSRRYTQ-UHFFFAOYSA-N 0.000 claims description 2
ZJZMGANTZSBHJZ-UHFFFAOYSA-N (7-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)-(4-methylpiperidin-1-yl)methanone Chemical compound C1CC(C)CCN1C(=O)C1=NN2C(C)=CC(C=3C=CC=CC=3)=NC2=C1 ZJZMGANTZSBHJZ-UHFFFAOYSA-N 0.000 claims description 2
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CHJOWHPQUASBRL-UHFFFAOYSA-N 2-(1-adamantyl)-1-(3,4-dihydro-1h-isoquinolin-2-yl)ethanone Chemical compound C1CC2=CC=CC=C2CN1C(=O)CC1(C2)CC(C3)CC2CC3C1 CHJOWHPQUASBRL-UHFFFAOYSA-N 0.000 claims description 2
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PYYAWGIWWYJBNR-UHFFFAOYSA-N 2-(2,4-dimethylphenoxy)-1-(6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)ethanone Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)COC1=CC=C(C)C=C1C PYYAWGIWWYJBNR-UHFFFAOYSA-N 0.000 claims description 2
CHSYLCUXRJCXFN-UHFFFAOYSA-N 2-(2,6-dimethylphenoxy)-n-(2-propan-2-ylphenyl)acetamide Chemical compound CC(C)C1=CC=CC=C1NC(=O)COC1=C(C)C=CC=C1C CHSYLCUXRJCXFN-UHFFFAOYSA-N 0.000 claims description 2
VIGAKWPOIGTBHP-UHFFFAOYSA-N 2-(2-aminophenyl)sulfanyl-1-(5-fluoro-2,3-dihydroindol-1-yl)ethanone Chemical compound NC1=CC=CC=C1SCC(=O)N1C2=CC=C(F)C=C2CC1 VIGAKWPOIGTBHP-UHFFFAOYSA-N 0.000 claims description 2
QTDRMKNBWKWZAT-UHFFFAOYSA-N 2-(2-bromo-4-methylphenoxy)-n-[2-(cyclohexen-1-yl)ethyl]acetamide Chemical compound BrC1=CC(C)=CC=C1OCC(=O)NCCC1=CCCCC1 QTDRMKNBWKWZAT-UHFFFAOYSA-N 0.000 claims description 2
JBIMBKPZHTYYSV-UHFFFAOYSA-N 2-(2-cyanophenyl)sulfanyl-n-[2-(trifluoromethyl)phenyl]benzamide Chemical compound FC(F)(F)C1=CC=CC=C1NC(=O)C1=CC=CC=C1SC1=CC=CC=C1C#N JBIMBKPZHTYYSV-UHFFFAOYSA-N 0.000 claims description 2
RHIGPRNANIWPMK-UHFFFAOYSA-N 2-(2-cyanophenyl)sulfanyl-n-cyclopentylbenzamide Chemical compound C=1C=CC=C(SC=2C(=CC=CC=2)C#N)C=1C(=O)NC1CCCC1 RHIGPRNANIWPMK-UHFFFAOYSA-N 0.000 claims description 2
GYVNLDXQFZLUNN-UHFFFAOYSA-N 2-(2-ethylphenyl)sulfanyl-3-[methyl(2-pyridin-4-ylethyl)amino]-n-prop-2-ynylpropanamide Chemical compound CCC1=CC=CC=C1SC(C(=O)NCC#C)CN(C)CCC1=CC=NC=C1 GYVNLDXQFZLUNN-UHFFFAOYSA-N 0.000 claims description 2
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KYADFMKHEIXPJH-UHFFFAOYSA-N 2-(4-chlorophenoxy)-n-[4-chloro-3-(trifluoromethyl)phenyl]acetamide Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)COC=2C=CC(Cl)=CC=2)=C1 KYADFMKHEIXPJH-UHFFFAOYSA-N 0.000 claims description 2
KHSBCQTVHXXWOR-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-n-[(2-hydroxyphenyl)methyl]-n-(2-methylpropyl)acetamide Chemical compound C=1C=C(O)C=CC=1CC(=O)N(CC(C)C)CC1=CC=CC=C1O KHSBCQTVHXXWOR-UHFFFAOYSA-N 0.000 claims description 2
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FYVCOFXRBWDYKD-UHFFFAOYSA-N 2-(6-oxo-6-piperidin-1-ylhexyl)isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1CCCCCC(=O)N1CCCCC1 FYVCOFXRBWDYKD-UHFFFAOYSA-N 0.000 claims description 2
ZYDUOYLUMSMWPM-UHFFFAOYSA-N 2-(cyclohexylamino)-N-(2-methoxydibenzofuran-3-yl)-1,3-thiazole-4-carboxamide Chemical compound COC1=CC(C2=CC=CC=C2O2)=C2C=C1NC(=O)C(N=1)=CSC=1NC1CCCCC1 ZYDUOYLUMSMWPM-UHFFFAOYSA-N 0.000 claims description 2
HUIMOLNHHAFFEU-UHFFFAOYSA-N 2-(cyclohexylamino)-n-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,3-thiazole-4-carboxamide Chemical compound C1CCC2=CC=CC=C2C1NC(=O)C(N=1)=CSC=1NC1CCCCC1 HUIMOLNHHAFFEU-UHFFFAOYSA-N 0.000 claims description 2
MWWOAZWEEHAJJX-UHFFFAOYSA-N 2-(cyclohexylamino)-n-(1-ethynylcyclohexyl)-1,3-thiazole-4-carboxamide Chemical compound C=1SC(NC2CCCCC2)=NC=1C(=O)NC1(C#C)CCCCC1 MWWOAZWEEHAJJX-UHFFFAOYSA-N 0.000 claims description 2
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IUSJOSOPIJDCMV-UHFFFAOYSA-N 2-(cyclohexylamino)-n-[2-(4-hydroxyphenyl)ethyl]-1,3-thiazole-4-carboxamide Chemical compound C1=CC(O)=CC=C1CCNC(=O)C1=CSC(NC2CCCCC2)=N1 IUSJOSOPIJDCMV-UHFFFAOYSA-N 0.000 claims description 2
ZQMPXFCWWNKNFB-UHFFFAOYSA-N 2-(cyclohexylamino)-n-[3-(1-hydroxyethyl)phenyl]-1,3-thiazole-4-carboxamide Chemical compound CC(O)C1=CC=CC(NC(=O)C=2N=C(NC3CCCCC3)SC=2)=C1 ZQMPXFCWWNKNFB-UHFFFAOYSA-N 0.000 claims description 2
AAHJNOMSGVULMS-UHFFFAOYSA-N 2-(cyclohexylamino)-n-pentan-3-yl-1,3-thiazole-4-carboxamide Chemical compound CCC(CC)NC(=O)C1=CSC(NC2CCCCC2)=N1 AAHJNOMSGVULMS-UHFFFAOYSA-N 0.000 claims description 2
JIBDQUYVHSTHGS-UHFFFAOYSA-N 2-(diethylamino)-n-[(1-phenylcyclopentyl)methyl]propanamide Chemical compound C=1C=CC=CC=1C1(CNC(=O)C(C)N(CC)CC)CCCC1 JIBDQUYVHSTHGS-UHFFFAOYSA-N 0.000 claims description 2
QMFWWRKULSMUSH-UHFFFAOYSA-N 2-(heptylcarbamoyl)bicyclo[2.2.1]hept-5-ene-3-carboxylic acid Chemical compound C1C2C=CC1C(C(=O)NCCCCCCC)C2C(O)=O QMFWWRKULSMUSH-UHFFFAOYSA-N 0.000 claims description 2
PJVLHKQTZLLMDV-UHFFFAOYSA-N 2-(hexylamino)-n-[(4-hydroxyphenyl)methyl]-n-methylacetamide Chemical compound CCCCCCNCC(=O)N(C)CC1=CC=C(O)C=C1 PJVLHKQTZLLMDV-UHFFFAOYSA-N 0.000 claims description 2
SJUHYWWBQFWWQS-UHFFFAOYSA-N 2-(piperidine-1-carbonyl)-5-piperidin-1-yl-1,3-oxazole-4-carbonitrile Chemical compound N=1C(C#N)=C(N2CCCCC2)OC=1C(=O)N1CCCCC1 SJUHYWWBQFWWQS-UHFFFAOYSA-N 0.000 claims description 2
DPEZMUJHPZIRQS-UHFFFAOYSA-N 2-[(2,6-difluorophenyl)methylamino]-n-[2-[3-(trifluoromethyl)phenyl]ethyl]acetamide Chemical compound FC1=CC=CC(F)=C1CNCC(=O)NCCC1=CC=CC(C(F)(F)F)=C1 DPEZMUJHPZIRQS-UHFFFAOYSA-N 0.000 claims description 2
GRCSGDXAMFCVSH-UHFFFAOYSA-N 2-[(2-amino-2-oxoethyl)-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]acetic acid Chemical compound COC1=CC(C(=O)N(CC(N)=O)CC(O)=O)=CC(C(=O)C=2N=CC=CC=2)=C1 GRCSGDXAMFCVSH-UHFFFAOYSA-N 0.000 claims description 2
ZBOQEIHWWSHQTC-UHFFFAOYSA-N 2-[(2-benzylsulfanylacetyl)-(2-methoxyethyl)amino]-n-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]ethyl]acetamide Chemical compound C=1C=CC=CC=1CSCC(=O)N(CCOC)CC(=O)NCCSCC1=C(F)C=CC=C1Cl ZBOQEIHWWSHQTC-UHFFFAOYSA-N 0.000 claims description 2
NHEHDFPGKKPRFX-UHFFFAOYSA-N 2-[(2-methylphenyl)methylsulfanyl]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC=CC=C1CSCC(=O)N1CCN(C=2C=CC=CC=2)CC1 NHEHDFPGKKPRFX-UHFFFAOYSA-N 0.000 claims description 2
ZSSONPIPZWGZFV-UHFFFAOYSA-N 2-[(3-bromophenyl)methylsulfanyl]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound BrC1=CC=CC(CSCC(=O)N2CCN(CC2)C=2C=CC=CC=2)=C1 ZSSONPIPZWGZFV-UHFFFAOYSA-N 0.000 claims description 2
OZWBTJRHLDARMF-UHFFFAOYSA-N 2-[(3-bromophenyl)methylsulfanyl]-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC=C1N1CCN(C(=O)CSCC=2C=C(Br)C=CC=2)CC1 OZWBTJRHLDARMF-UHFFFAOYSA-N 0.000 claims description 2
YUYYOUDVNNTGBH-UHFFFAOYSA-N 2-[(3-bromophenyl)methylsulfanyl]-1-piperidin-1-ylethanone Chemical compound BrC1=CC=CC(CSCC(=O)N2CCCCC2)=C1 YUYYOUDVNNTGBH-UHFFFAOYSA-N 0.000 claims description 2
DJHQDEYOSLJOLU-UHFFFAOYSA-N 2-[(4-methylphenyl)methylsulfanyl]-1-piperidin-1-ylethanone Chemical compound C1=CC(C)=CC=C1CSCC(=O)N1CCCCC1 DJHQDEYOSLJOLU-UHFFFAOYSA-N 0.000 claims description 2
RCUQXNIZNQXWHL-UHFFFAOYSA-N 2-[(5,6-dimethyl-4-oxo-3h-thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-n-(furan-2-ylmethyl)acetamide Chemical compound N1C(=O)C=2C(C)=C(C)SC=2N=C1SCC(=O)NCC1=CC=CO1 RCUQXNIZNQXWHL-UHFFFAOYSA-N 0.000 claims description 2
UULSGYZITMMALJ-UHFFFAOYSA-N 2-[(5-phenyl-1h-imidazol-2-yl)sulfanyl]-n-(2,4,4-trimethylpentan-2-yl)acetamide Chemical compound N1C(SCC(=O)NC(C)(C)CC(C)(C)C)=NC=C1C1=CC=CC=C1 UULSGYZITMMALJ-UHFFFAOYSA-N 0.000 claims description 2
OROJQMWAAMSHCB-UHFFFAOYSA-N 2-[(6-amino-1,3-benzothiazol-2-yl)sulfanyl]-n-cyclohexylacetamide Chemical compound S1C2=CC(N)=CC=C2N=C1SCC(=O)NC1CCCCC1 OROJQMWAAMSHCB-UHFFFAOYSA-N 0.000 claims description 2
KDLAKIOJEPTQDT-UHFFFAOYSA-N 2-[1-(2,5-dimethylphenyl)tetrazol-5-yl]sulfanyl-n-phenyl-n-propan-2-ylacetamide Chemical compound C=1C=CC=CC=1N(C(C)C)C(=O)CSC1=NN=NN1C1=CC(C)=CC=C1C KDLAKIOJEPTQDT-UHFFFAOYSA-N 0.000 claims description 2
FZAXAPQYHLECOI-UHFFFAOYSA-N 2-[1-(2,6-dimethylmorpholin-4-yl)-1-oxopropan-2-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C)C(=O)N1CC(C)OC(C)C1 FZAXAPQYHLECOI-UHFFFAOYSA-N 0.000 claims description 2
SAIAGGQCMGMEIA-UHFFFAOYSA-N 2-[1-(4-chlorophenyl)sulfonylbenzimidazol-2-yl]sulfanyl-n-(thiophen-2-ylmethyl)acetamide Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)N1C2=CC=CC=C2N=C1SCC(=O)NCC1=CC=CS1 SAIAGGQCMGMEIA-UHFFFAOYSA-N 0.000 claims description 2
WHZXXYYHHHQBQY-UHFFFAOYSA-N 2-[1-(azepan-1-yl)-3-methyl-1-oxobutan-2-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C(C)C)C(=O)N1CCCCCC1 WHZXXYYHHHQBQY-UHFFFAOYSA-N 0.000 claims description 2
TVUZQZKYWYADOX-UHFFFAOYSA-N 2-[1-morpholin-4-yl-3-(4-nitrophenyl)-1-oxopropan-2-yl]isoindole-1,3-dione Chemical compound C1=CC([N+](=O)[O-])=CC=C1CC(C(=O)N1CCOCC1)N1C(=O)C2=CC=CC=C2C1=O TVUZQZKYWYADOX-UHFFFAOYSA-N 0.000 claims description 2
XDUFXJIZTFOCLG-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-2-adamantyl]-1-(4-methylpiperazin-1-yl)ethanone Chemical compound C1CN(C)CCN1C(=O)CC1(C=2C=CC(Cl)=CC=2)C(C2)CC3CC2CC1C3 XDUFXJIZTFOCLG-UHFFFAOYSA-N 0.000 claims description 2
GGKNHRRHTQJTTL-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-2-adamantyl]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)CC2(C3CC4CC(C3)CC2C4)C=2C=CC(Cl)=CC=2)CC1 GGKNHRRHTQJTTL-UHFFFAOYSA-N 0.000 claims description 2
OGOUTJBZNBTLDZ-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-2-adamantyl]-n-(2-hydroxyethyl)acetamide Chemical compound C1C2CC(C3)CC1CC3C2(CC(=O)NCCO)C1=CC=C(Cl)C=C1 OGOUTJBZNBTLDZ-UHFFFAOYSA-N 0.000 claims description 2
BOKVJFHTLJCVEB-UHFFFAOYSA-N 2-[2-(5-bicyclo[2.2.1]hept-2-enylamino)-4-oxo-1,3-thiazol-5-yl]-n-(2-chlorophenyl)acetamide Chemical compound ClC1=CC=CC=C1NC(=O)CC1C(=O)N=C(NC2C3CC(C=C3)C2)S1 BOKVJFHTLJCVEB-UHFFFAOYSA-N 0.000 claims description 2
HPOGVCKERGTYKP-UHFFFAOYSA-N 2-[2-[[(2-amino-2-oxoethyl)-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC(N)=O)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 HPOGVCKERGTYKP-UHFFFAOYSA-N 0.000 claims description 2
JYVBDKZKULSJKM-UHFFFAOYSA-N 2-[2-[[2-methoxyethyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)C=2N=CC=CC=2)=CC=1C(=O)N(CCOC)CC1=CC=CC=C1OCC(O)=O JYVBDKZKULSJKM-UHFFFAOYSA-N 0.000 claims description 2
LLOIADUZZZXHIZ-UHFFFAOYSA-N 2-[2-[[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-(3-methylbutyl)amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CCC(C)C)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 LLOIADUZZZXHIZ-UHFFFAOYSA-N 0.000 claims description 2
IHPWLYWFNHBBJS-UHFFFAOYSA-N 2-[2-[[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-methylamino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(C)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 IHPWLYWFNHBBJS-UHFFFAOYSA-N 0.000 claims description 2
NQGOXWWAGHYVOM-UHFFFAOYSA-N 2-[2-[[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-pyridin-4-ylamino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC=2C(=CC=CC=2)OCC(O)=O)C=2C=CN=CC=2)=CC=1C(=O)C1=CC=CC=N1 NQGOXWWAGHYVOM-UHFFFAOYSA-N 0.000 claims description 2
BAYIZJYSJMYCJL-UHFFFAOYSA-N 2-[2-[[cyclopentyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC=2C(=CC=CC=2)OCC(O)=O)C2CCCC2)=CC=1C(=O)C1=CC=CC=N1 BAYIZJYSJMYCJL-UHFFFAOYSA-N 0.000 claims description 2
SOQRFSOECBDGBK-UHFFFAOYSA-N 2-[2-[[cyclopropyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC=2C(=CC=CC=2)OCC(O)=O)C2CC2)=CC=1C(=O)C1=CC=CC=N1 SOQRFSOECBDGBK-UHFFFAOYSA-N 0.000 claims description 2
UHBRHCQVLCYCRF-UHFFFAOYSA-N 2-[2-[[cyclopropylmethyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]phenoxy]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC2CC2)CC=2C(=CC=CC=2)OCC(O)=O)=CC=1C(=O)C1=CC=CC=N1 UHBRHCQVLCYCRF-UHFFFAOYSA-N 0.000 claims description 2
QXOUJYYPDNMONW-UHFFFAOYSA-N 2-[3-(2-ethylpiperidin-1-yl)-3-oxopropyl]isoindole-1,3-dione Chemical compound CCC1CCCCN1C(=O)CCN1C(=O)C2=CC=CC=C2C1=O QXOUJYYPDNMONW-UHFFFAOYSA-N 0.000 claims description 2
MBRMOBDUCLMTMR-UHFFFAOYSA-N 2-[3-(azepane-1-carbonyl)phenyl]isoindole-1,3-dione Chemical compound C=1C=CC(N2C(C3=CC=CC=C3C2=O)=O)=CC=1C(=O)N1CCCCCC1 MBRMOBDUCLMTMR-UHFFFAOYSA-N 0.000 claims description 2
WSEFWDLSBIPVAF-UHFFFAOYSA-N 2-[3-[4-(2-chlorophenyl)piperazin-1-yl]-3-oxopropyl]isoindole-1,3-dione Chemical compound ClC1=CC=CC=C1N1CCN(C(=O)CCN2C(C3=CC=CC=C3C2=O)=O)CC1 WSEFWDLSBIPVAF-UHFFFAOYSA-N 0.000 claims description 2
GVQXUZISFDJWHR-UHFFFAOYSA-N 2-[3-imidazol-1-ylpropyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CCCN2C=NC=C2)CC(O)=O)=CC=1C(=O)C1=CC=CC=N1 GVQXUZISFDJWHR-UHFFFAOYSA-N 0.000 claims description 2
BMJFHITXZQCGRM-UHFFFAOYSA-N 2-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-n-cyclohexylacetamide Chemical compound C1CN(C=2SC3=CC=CC=C3N=2)CCN1CC(=O)NC1CCCCC1 BMJFHITXZQCGRM-UHFFFAOYSA-N 0.000 claims description 2
BLNIYEIMTLMHGY-UHFFFAOYSA-N 2-[4-(2-methylpropyl)phenyl]-n-(1-phenylethyl)propanamide Chemical compound C1=CC(CC(C)C)=CC=C1C(C)C(=O)NC(C)C1=CC=CC=C1 BLNIYEIMTLMHGY-UHFFFAOYSA-N 0.000 claims description 2
JBDYWCYCAGIOLC-UHFFFAOYSA-N 2-[4-(3,3,4-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C=C1)=CC=C1C(=O)N(C1)C2CC1C(C)C(C)(C)C2 JBDYWCYCAGIOLC-UHFFFAOYSA-N 0.000 claims description 2
YFQOUUOEKOIYSD-UHFFFAOYSA-N 2-[4-(adamantane-1-carbonylamino)phenoxy]acetic acid Chemical compound C1=CC(OCC(=O)O)=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 YFQOUUOEKOIYSD-UHFFFAOYSA-N 0.000 claims description 2
MQMLZZKIPVOGLT-UHFFFAOYSA-N 2-[[2-(2-phenyl-2-adamantyl)acetyl]amino]ethyl thiophene-2-carboxylate Chemical compound C=1C=CSC=1C(=O)OCCNC(=O)CC1(C2CC3CC(C2)CC1C3)C1=CC=CC=C1 MQMLZZKIPVOGLT-UHFFFAOYSA-N 0.000 claims description 2
KBEPEFQMIXNIJJ-UHFFFAOYSA-N 2-[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]-pyridin-4-ylamino]acetic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC(O)=O)C=2C=CN=CC=2)=CC=1C(=O)C1=CC=CC=N1 KBEPEFQMIXNIJJ-UHFFFAOYSA-N 0.000 claims description 2
IXVDGRUBVVVBSB-UHFFFAOYSA-N 2-benzylsulfanyl-n-[2-(2-methoxyphenoxy)ethyl]acetamide Chemical compound COC1=CC=CC=C1OCCNC(=O)CSCC1=CC=CC=C1 IXVDGRUBVVVBSB-UHFFFAOYSA-N 0.000 claims description 2
ORKVVRTYVOGARV-UHFFFAOYSA-N 2-bromo-N-(6-tricyclo[3.2.1.02,4]octanylmethyl)benzamide Chemical compound BrC1=CC=CC=C1C(=O)NCC1C(C2C3C2)CC3C1 ORKVVRTYVOGARV-UHFFFAOYSA-N 0.000 claims description 2
DDDRVGVYZGDDCJ-UHFFFAOYSA-N 2-bromo-n-(2,4,4-trimethylpentan-2-yl)benzamide Chemical compound CC(C)(C)CC(C)(C)NC(=O)C1=CC=CC=C1Br DDDRVGVYZGDDCJ-UHFFFAOYSA-N 0.000 claims description 2
WGWNDVRLEDJPAD-UHFFFAOYSA-N 2-bromo-n-cycloheptylbenzamide Chemical compound BrC1=CC=CC=C1C(=O)NC1CCCCCC1 WGWNDVRLEDJPAD-UHFFFAOYSA-N 0.000 claims description 2
KPWBSOREDPETKJ-UHFFFAOYSA-N 2-bromo-n-methyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C)C(=O)C1=CC=CC=C1Br KPWBSOREDPETKJ-UHFFFAOYSA-N 0.000 claims description 2
QFRKSSIXIDGZIO-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-(3,3,5-trimethylcyclohexyl)benzamide Chemical compound C1C(C)(C)CC(C)CC1NC(=O)C1=CC(F)=C(F)C=C1Cl QFRKSSIXIDGZIO-UHFFFAOYSA-N 0.000 claims description 2
LWDNHPDVAIHURM-UHFFFAOYSA-N 2-chloro-n-(2-cyclohexylethyl)benzamide Chemical compound ClC1=CC=CC=C1C(=O)NCCC1CCCCC1 LWDNHPDVAIHURM-UHFFFAOYSA-N 0.000 claims description 2
JSBARNARTCXPMV-UHFFFAOYSA-N 2-chloro-n-(3,4-dimethylphenyl)benzamide Chemical compound C1=C(C)C(C)=CC=C1NC(=O)C1=CC=CC=C1Cl JSBARNARTCXPMV-UHFFFAOYSA-N 0.000 claims description 2
DXULUNDOVVEQAM-UHFFFAOYSA-N 2-chloro-n-[2-[(4-ethylbenzoyl)amino]ethyl]-n-(4-fluorophenyl)benzamide Chemical compound C1=CC(CC)=CC=C1C(=O)NCCN(C=1C=CC(F)=CC=1)C(=O)C1=CC=CC=C1Cl DXULUNDOVVEQAM-UHFFFAOYSA-N 0.000 claims description 2
GVZZYZHKWJWMDV-UHFFFAOYSA-N 2-chloro-n-cycloheptylbenzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1CCCCCC1 GVZZYZHKWJWMDV-UHFFFAOYSA-N 0.000 claims description 2
RLCAWBGFEAYDNE-UHFFFAOYSA-N 2-chloro-n-cyclooctyl-4,5-difluorobenzamide Chemical compound C1=C(F)C(F)=CC(Cl)=C1C(=O)NC1CCCCCCC1 RLCAWBGFEAYDNE-UHFFFAOYSA-N 0.000 claims description 2
OEYWSNRVIODBJL-UHFFFAOYSA-N 2-chloro-n-methyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C)C(=O)C1=CC=CC=C1Cl OEYWSNRVIODBJL-UHFFFAOYSA-N 0.000 claims description 2
CHTAIYIAJKCWFE-UHFFFAOYSA-N 2-cyclohexyl-n-(2,6-dimethylphenyl)-n-(furan-2-ylmethyl)acetamide Chemical compound CC1=CC=CC(C)=C1N(C(=O)CC1CCCCC1)CC1=CC=CO1 CHTAIYIAJKCWFE-UHFFFAOYSA-N 0.000 claims description 2
SQDWNHRSJXSPSO-UHFFFAOYSA-N 2-hydroxy-4,4-dimethyl-6-oxo-n-phenylcyclohexene-1-carboxamide Chemical compound O=C1CC(C)(C)CC(O)=C1C(=O)NC1=CC=CC=C1 SQDWNHRSJXSPSO-UHFFFAOYSA-N 0.000 claims description 2
WMHJSKQIZWRPOI-UHFFFAOYSA-N 2-methoxy-n-[(1-phenylcyclopentyl)methyl]benzamide Chemical compound COC1=CC=CC=C1C(=O)NCC1(C=2C=CC=CC=2)CCCC1 WMHJSKQIZWRPOI-UHFFFAOYSA-N 0.000 claims description 2
ASUDFOJKTJLAIK-UHFFFAOYSA-N 2-methoxyethanamine Chemical compound COCCN ASUDFOJKTJLAIK-UHFFFAOYSA-N 0.000 claims description 2
XICOIUVERMHLLR-UHFFFAOYSA-N 2-morpholin-4-yl-n-[(1-phenylcyclopentyl)methyl]acetamide Chemical compound C1CCCC1(C=1C=CC=CC=1)CNC(=O)CN1CCOCC1 XICOIUVERMHLLR-UHFFFAOYSA-N 0.000 claims description 2
CIMNDLLQVWHXSU-UHFFFAOYSA-N 2-morpholin-4-yl-n-[(1-phenylcyclopentyl)methyl]propanamide Chemical compound C1CCCC1(C=1C=CC=CC=1)CNC(=O)C(C)N1CCOCC1 CIMNDLLQVWHXSU-UHFFFAOYSA-N 0.000 claims description 2
YTSYVPITBGXZGX-UHFFFAOYSA-N 2-phenoxy-1-[4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]ethanone Chemical compound FC(F)(F)C1=CC=CC=C1CN1CCN(C(=O)COC=2C=CC=CC=2)CC1 YTSYVPITBGXZGX-UHFFFAOYSA-N 0.000 claims description 2
AOAAKPKESCSLKH-UHFFFAOYSA-N 2-phenyl-1-(3-phenylpyrrolidin-1-yl)ethanone Chemical compound C1CC(C=2C=CC=CC=2)CN1C(=O)CC1=CC=CC=C1 AOAAKPKESCSLKH-UHFFFAOYSA-N 0.000 claims description 2
AFHVHPLKUVOZQH-UHFFFAOYSA-N 2-phenyl-n-[2-(trifluoromethyl)phenyl]butanamide Chemical compound C=1C=CC=CC=1C(CC)C(=O)NC1=CC=CC=C1C(F)(F)F AFHVHPLKUVOZQH-UHFFFAOYSA-N 0.000 claims description 2
QUQKAXPIRYDMHC-UHFFFAOYSA-N 3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl(phenyl)methanone Chemical compound C1CCC2CCCCC2N1C(=O)C1=CC=CC=C1 QUQKAXPIRYDMHC-UHFFFAOYSA-N 0.000 claims description 2
JALSUCQBKFICGJ-UHFFFAOYSA-N 3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl-[1-(4-chlorophenyl)sulfonylpiperidin-3-yl]methanone Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)N1CC(C(=O)N2C3CCCCC3CCC2)CCC1 JALSUCQBKFICGJ-UHFFFAOYSA-N 0.000 claims description 2
GFAMNPSIKLWQFG-UHFFFAOYSA-N 3,4,4a,8a-tetrahydro-2h-quinolin-1-yl-(4-fluorophenyl)methanone Chemical compound C1=CC(F)=CC=C1C(=O)N1C2C=CC=CC2CCC1 GFAMNPSIKLWQFG-UHFFFAOYSA-N 0.000 claims description 2
JIQMXQBHAQRZIC-UHFFFAOYSA-N 3,4,5-trimethoxy-n-[(4-methylphenyl)methyl]-n-[6-(pyridin-2-ylamino)hexyl]benzamide Chemical compound COC1=C(OC)C(OC)=CC(C(=O)N(CCCCCCNC=2N=CC=CC=2)CC=2C=CC(C)=CC=2)=C1 JIQMXQBHAQRZIC-UHFFFAOYSA-N 0.000 claims description 2
125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 2
OIHDSMHPHPZZFH-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[3-bromo-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=C(Br)C(C(=O)N3CC4CCCN4CC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CC=C1 OIHDSMHPHPZZFH-UHFFFAOYSA-N 0.000 claims description 2
PKWHNERZGTZPHN-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[3-chloro-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=C(Cl)C(C(=O)N3CC4CCCN4CC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CC=C1 PKWHNERZGTZPHN-UHFFFAOYSA-N 0.000 claims description 2
YTFFNTUHKXBGGP-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=C(OC)C(OC)=CC=C1C1=NC2=CC(C(=O)N3CC4CCCN4CC3)=NN2C(C(F)(F)F)=C1 YTFFNTUHKXBGGP-UHFFFAOYSA-N 0.000 claims description 2
SBZUBUKXRIKRTG-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=C(OC)C(OC)=CC=C1C1=NC2=C(C(=O)N3CC4CCCN4CC3)C=NN2C(C(F)(F)F)=C1 SBZUBUKXRIKRTG-UHFFFAOYSA-N 0.000 claims description 2
XLHRMMKTNCDVRQ-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(C)=CC=C1C1=NC2=CC(C(=O)N3CC4CCCN4CC3)=NN2C(C(F)(F)F)=C1 XLHRMMKTNCDVRQ-UHFFFAOYSA-N 0.000 claims description 2
MHNNEIFFBMDCCR-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(C)=CC=C1C1=NC2=C(C(=O)N3CC4CCCN4CC3)C=NN2C(C(F)(F)F)=C1 MHNNEIFFBMDCCR-UHFFFAOYSA-N 0.000 claims description 2
DKBNJAUUKBWPGF-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=CC(C(=O)N3CC4CCCN4CC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CC=C1 DKBNJAUUKBWPGF-UHFFFAOYSA-N 0.000 claims description 2
YDPRVLBFSLWEOG-UHFFFAOYSA-N 3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=CC(C(=O)N3CC4CCCN4CC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CS1 YDPRVLBFSLWEOG-UHFFFAOYSA-N 0.000 claims description 2
HFYZIIYHIGTAII-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-(2-methylphenyl)methanone Chemical compound CC1=CC=CC=C1C(=O)N1CC2=CC=CC=C2CC1 HFYZIIYHIGTAII-UHFFFAOYSA-N 0.000 claims description 2
PXRUDTKTGZDJHY-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-(3,4-dimethylphenyl)methanone Chemical compound C1=C(C)C(C)=CC=C1C(=O)N1CC2=CC=CC=C2CC1 PXRUDTKTGZDJHY-UHFFFAOYSA-N 0.000 claims description 2
XTORAXYWQZOLLE-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-(5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical compound C1CC2=CC=CC=C2CN1C(=O)C(C=N1)=C2N1C(C)=CC(C)=N2 XTORAXYWQZOLLE-UHFFFAOYSA-N 0.000 claims description 2
WSDAQQKBGUZLQI-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[1-(2-nitrophenyl)sulfonylpiperidin-3-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC=C1S(=O)(=O)N1CC(C(=O)N2CC3=CC=CC=C3CC2)CCC1 WSDAQQKBGUZLQI-UHFFFAOYSA-N 0.000 claims description 2
OSQDCCVNPHTASZ-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[3-(dimethylamino)phenyl]methanone Chemical compound CN(C)C1=CC=CC(C(=O)N2CC3=CC=CC=C3CC2)=C1 OSQDCCVNPHTASZ-UHFFFAOYSA-N 0.000 claims description 2
WHNCCASBJPONLV-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC(C(=O)N3CC4=CC=CC=C4CC3)=NN2C(C(F)(F)F)=C1 WHNCCASBJPONLV-UHFFFAOYSA-N 0.000 claims description 2
MRURCMPFAUQJND-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CC4=CC=CC=C4CC3)C=NN2C(C(F)(F)F)=C1 MRURCMPFAUQJND-UHFFFAOYSA-N 0.000 claims description 2
JJJGXICJWHMTIF-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1=NC2=CC(C(=O)N3CC4=CC=CC=C4CC3)=NN2C(C(F)(F)F)=C1 JJJGXICJWHMTIF-UHFFFAOYSA-N 0.000 claims description 2
VUEGCYLRSGBWDK-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=CC(C(=O)N3CC4=CC=CC=C4CC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CO1 VUEGCYLRSGBWDK-UHFFFAOYSA-N 0.000 claims description 2
HAABNOIHSDVBOG-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=CC(C(=O)N3CC4=CC=CC=C4CC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CC=C1 HAABNOIHSDVBOG-UHFFFAOYSA-N 0.000 claims description 2
MCHZXTCMFSCBDH-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(1-thiophen-2-ylsulfonylpiperidin-4-yl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(CC1)CCN1S(=O)(=O)C1=CC=CS1 MCHZXTCMFSCBDH-UHFFFAOYSA-N 0.000 claims description 2
ISSLGPYALULXJH-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(2-fluorophenyl)methanone Chemical compound FC1=CC=CC=C1C(=O)N1C2=CC=CC=C2CCC1 ISSLGPYALULXJH-UHFFFAOYSA-N 0.000 claims description 2
SRCUDAZOLJXOLJ-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(2-methylphenyl)methanone Chemical compound CC1=CC=CC=C1C(=O)N1C2=CC=CC=C2CCC1 SRCUDAZOLJXOLJ-UHFFFAOYSA-N 0.000 claims description 2
ZVZWIRBGKZERRU-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(3-iodophenyl)methanone Chemical compound IC1=CC=CC(C(=O)N2C3=CC=CC=C3CCC2)=C1 ZVZWIRBGKZERRU-UHFFFAOYSA-N 0.000 claims description 2
BUTVSAACRCEEOE-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(3-piperidin-1-ylsulfonylphenyl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(C=1)=CC=CC=1S(=O)(=O)N1CCCCC1 BUTVSAACRCEEOE-UHFFFAOYSA-N 0.000 claims description 2
VZHRCTGZYLKICF-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(4-methylphenyl)methanone Chemical compound C1=CC(C)=CC=C1C(=O)N1C2=CC=CC=C2CCC1 VZHRCTGZYLKICF-UHFFFAOYSA-N 0.000 claims description 2
ZWYNNQSBWAQDOC-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(4-morpholin-4-ylsulfonylphenyl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(C=C1)=CC=C1S(=O)(=O)N1CCOCC1 ZWYNNQSBWAQDOC-UHFFFAOYSA-N 0.000 claims description 2
GOFUZVFSHNIODA-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(4-pyrrolidin-1-ylsulfonylphenyl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(C=C1)=CC=C1S(=O)(=O)N1CCCC1 GOFUZVFSHNIODA-UHFFFAOYSA-N 0.000 claims description 2
BKOXVBZUXNUYTM-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(5,7-diphenylpyrazolo[1,5-a]pyrimidin-2-yl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(=NN12)C=C1N=C(C=1C=CC=CC=1)C=C2C1=CC=CC=C1 BKOXVBZUXNUYTM-UHFFFAOYSA-N 0.000 claims description 2
GCDCLPAENKUMNC-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-(5,7-diphenylpyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(=C1N=2)C=NN1C(C=1C=CC=CC=1)=CC=2C1=CC=CC=C1 GCDCLPAENKUMNC-UHFFFAOYSA-N 0.000 claims description 2
QCNCHPUMDFGFPU-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[3-(4-phenylpiperazin-1-yl)sulfonylphenyl]methanone Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(C=1)=CC=CC=1S(=O)(=O)N(CC1)CCN1C1=CC=CC=C1 QCNCHPUMDFGFPU-UHFFFAOYSA-N 0.000 claims description 2
LDINXKSIYMFXQV-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound COC1=CC=CC(C2=NC3=C(C(=O)N4C5=CC=CC=C5CCC4)C=NN3C(=C2)C(F)(F)F)=C1 LDINXKSIYMFXQV-UHFFFAOYSA-N 0.000 claims description 2
VVVLQAZYRHKVNG-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(F)=CC=C1C1=NC2=C(C(=O)N3C4=CC=CC=C4CCC3)C=NN2C(C(F)(F)F)=C1 VVVLQAZYRHKVNG-UHFFFAOYSA-N 0.000 claims description 2
JYATYPXAMLBBOF-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1=NC2=CC(C(=O)N3C4=CC=CC=C4CCC3)=NN2C(C(F)(F)F)=C1 JYATYPXAMLBBOF-UHFFFAOYSA-N 0.000 claims description 2
NMVLHCGZYNMSRC-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound N=1C2=C(C(=O)N3C4=CC=CC=C4CCC3)C=NN2C(C(F)(F)F)=CC=1C1=CC=CO1 NMVLHCGZYNMSRC-UHFFFAOYSA-N 0.000 claims description 2
NJWOILOOALTRHT-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=CC(C(=O)N3C4=CC=CC=C4CCC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CC=C1 NJWOILOOALTRHT-UHFFFAOYSA-N 0.000 claims description 2
MPOFHNPLTNLFTC-UHFFFAOYSA-N 3,4-dihydro-2h-quinolin-1-yl-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1C2=CC(C(=O)N3C4=CC=CC=C4CCC3)=NN2C(C(F)(F)F)=CC=1C1=CC=CS1 MPOFHNPLTNLFTC-UHFFFAOYSA-N 0.000 claims description 2
AEGHNVIUXMRJME-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-3-(2-methoxyphenyl)-1-pyrrolidin-1-ylpropan-1-one Chemical compound COC1=CC=CC=C1C(C=1C=C2OCOC2=CC=1)CC(=O)N1CCCC1 AEGHNVIUXMRJME-UHFFFAOYSA-N 0.000 claims description 2
IZVZFYJEVTWHHM-UHFFFAOYSA-N 3-(1,3-dioxoisoindol-2-yl)-n-(2-methylcyclohexyl)propanamide Chemical compound CC1CCCCC1NC(=O)CCN1C(=O)C2=CC=CC=C2C1=O IZVZFYJEVTWHHM-UHFFFAOYSA-N 0.000 claims description 2
OKOUKEMKLYMBMZ-UHFFFAOYSA-N 3-(1-benzylimidazol-2-yl)sulfanyl-n-cyclohexylpropanamide Chemical compound C1CCCCC1NC(=O)CCSC1=NC=CN1CC1=CC=CC=C1 OKOUKEMKLYMBMZ-UHFFFAOYSA-N 0.000 claims description 2
QINSYGOHQYKFPF-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-cyclohexyl-n-methylprop-2-enamide Chemical compound C=1C=CC=C(Cl)C=1C=CC(=O)N(C)C1CCCCC1 QINSYGOHQYKFPF-UHFFFAOYSA-N 0.000 claims description 2
HGKDAPBOUPXJKC-UHFFFAOYSA-N 3-(2-hydroxyphenyl)-1,3-di(piperidin-1-yl)propan-1-one Chemical compound OC1=CC=CC=C1C(N1CCCCC1)CC(=O)N1CCCCC1 HGKDAPBOUPXJKC-UHFFFAOYSA-N 0.000 claims description 2
PREGFDQQYHBIGQ-UHFFFAOYSA-N 3-(3,4-dihydro-2h-quinoline-1-carbonyl)-n-phenylbenzenesulfonamide Chemical compound C1CCC2=CC=CC=C2N1C(=O)C(C=1)=CC=CC=1S(=O)(=O)NC1=CC=CC=C1 PREGFDQQYHBIGQ-UHFFFAOYSA-N 0.000 claims description 2
HZHSTMOFYQBVPV-UHFFFAOYSA-N 3-(4-fluorophenyl)-1-(4-phenylpiperidin-1-yl)but-2-en-1-one Chemical compound C=1C=C(F)C=CC=1C(C)=CC(=O)N(CC1)CCC1C1=CC=CC=C1 HZHSTMOFYQBVPV-UHFFFAOYSA-N 0.000 claims description 2
FTYKJOBQOANJJP-UHFFFAOYSA-N 3-(4-methylphenyl)-n-propan-2-yladamantane-1-carboxamide Chemical compound C1C(C(=O)NC(C)C)(C2)CC(C3)CC1CC32C1=CC=C(C)C=C1 FTYKJOBQOANJJP-UHFFFAOYSA-N 0.000 claims description 2
JWZIWHICRPFTPD-UHFFFAOYSA-N 3-(6-chloropyridin-2-yl)oxy-n-ethylbenzamide Chemical compound CCNC(=O)C1=CC=CC(OC=2N=C(Cl)C=CC=2)=C1 JWZIWHICRPFTPD-UHFFFAOYSA-N 0.000 claims description 2
RAWVSRAIUPFWKY-UHFFFAOYSA-N 3-[1-(3-cyclohexylpropanoyl)piperidin-4-yl]-1h-benzimidazol-2-one Chemical compound C1CC(N2C(NC3=CC=CC=C32)=O)CCN1C(=O)CCC1CCCCC1 RAWVSRAIUPFWKY-UHFFFAOYSA-N 0.000 claims description 2
VIXSEPGMXMZCNJ-UHFFFAOYSA-N 3-[1-(6-phenylhexanoyl)piperidin-4-yl]-1h-benzimidazol-2-one Chemical compound C1CC(N2C(NC3=CC=CC=C32)=O)CCN1C(=O)CCCCCC1=CC=CC=C1 VIXSEPGMXMZCNJ-UHFFFAOYSA-N 0.000 claims description 2
KYKSBULMCOJGHZ-UHFFFAOYSA-N 3-[2-(1,3-dioxoisoindol-2-yl)ethyl]adamantane-1-carboxylic acid Chemical compound O=C1C2=CC=CC=C2C(=O)N1CCC1(C2)CC(C3)CC2CC3(C(=O)O)C1 KYKSBULMCOJGHZ-UHFFFAOYSA-N 0.000 claims description 2
OMGQRBXCEOHLIC-UHFFFAOYSA-N 3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]isochromen-1-one Chemical compound CC1=CC=CC(N2CCN(CC2)C(=O)C=2OC(=O)C3=CC=CC=C3C=2)=C1C OMGQRBXCEOHLIC-UHFFFAOYSA-N 0.000 claims description 2
KYQYKLYWKGVGAP-UHFFFAOYSA-N 3-[4-(2-ethoxyphenyl)piperazine-1-carbonyl]isochromen-1-one Chemical compound CCOC1=CC=CC=C1N1CCN(C(=O)C=2OC(=O)C3=CC=CC=C3C=2)CC1 KYQYKLYWKGVGAP-UHFFFAOYSA-N 0.000 claims description 2
KANGNMIFFURMPC-UHFFFAOYSA-N 3-[[(2-amino-2-oxoethyl)-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]benzoic acid Chemical compound C=1C(OC)=CC(C(=O)N(CC(N)=O)CC=2C=C(C=CC=2)C(O)=O)=CC=1C(=O)C1=CC=CC=N1 KANGNMIFFURMPC-UHFFFAOYSA-N 0.000 claims description 2
NJHXKVRXNBUPLG-UHFFFAOYSA-N 3-[[3-imidazol-1-ylpropyl-[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]methyl]benzoic acid Chemical compound C=1C(OC)=CC(C(=O)N(CCCN2C=NC=C2)CC=2C=C(C=CC=2)C(O)=O)=CC=1C(=O)C1=CC=CC=N1 NJHXKVRXNBUPLG-UHFFFAOYSA-N 0.000 claims description 2
QSSZFEXITQOVAN-UHFFFAOYSA-N 3-amino-n-cyclohexyl-n-methylbenzamide Chemical compound C=1C=CC(N)=CC=1C(=O)N(C)C1CCCCC1 QSSZFEXITQOVAN-UHFFFAOYSA-N 0.000 claims description 2
TVCPFXRYXOOVCW-UHFFFAOYSA-N 3-bicyclo[2.2.1]heptanyl-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone Chemical compound CC1=CC=CC(N2CCN(CC2)C(=O)C2C3CCC(C3)C2)=C1C TVCPFXRYXOOVCW-UHFFFAOYSA-N 0.000 claims description 2
VGOUETQRBKNMCS-UHFFFAOYSA-N 3-bicyclo[2.2.1]heptanyl-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone Chemical compound CCOC1=CC=CC=C1N1CCN(C(=O)C2C3CCC(C3)C2)CC1 VGOUETQRBKNMCS-UHFFFAOYSA-N 0.000 claims description 2
MXPUPKZRQSPLBY-UHFFFAOYSA-N 3-bromo-5-(4-bromophenyl)-n-cyclohexyl-n-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=C(Br)C=1C(=O)N(C)C1CCCCC1 MXPUPKZRQSPLBY-UHFFFAOYSA-N 0.000 claims description 2
SXYTYMZPKCYNCQ-UHFFFAOYSA-N 3-bromo-n-[3-methyl-1-oxo-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)pentan-2-yl]benzamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C(C(C)CC)NC(=O)C1=CC=CC(Br)=C1 SXYTYMZPKCYNCQ-UHFFFAOYSA-N 0.000 claims description 2
CTXXXHCJUJZTKC-UHFFFAOYSA-N 3-bromo-n-cyclohexyl-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound N=1N2C(C(F)(F)F)=CC(C=3OC=CC=3)=NC2=C(Br)C=1C(=O)NC1CCCCC1 CTXXXHCJUJZTKC-UHFFFAOYSA-N 0.000 claims description 2
SPCUVPOVZSGXTC-UHFFFAOYSA-N 3-bromo-n-cyclohexyl-n-methyl-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound N=1N2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C(Br)C=1C(=O)N(C)C1CCCCC1 SPCUVPOVZSGXTC-UHFFFAOYSA-N 0.000 claims description 2
LHOPHTDOMJORCU-UHFFFAOYSA-N 3-chloro-5-(4-methoxyphenyl)-n-methyl-n-(2-pyridin-2-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(Cl)C(C(=O)N(C)CCC=3N=CC=CC=3)=NN2C(C(F)(F)F)=C1 LHOPHTDOMJORCU-UHFFFAOYSA-N 0.000 claims description 2
NIBGOYHSCONGHL-UHFFFAOYSA-N 3-chloro-n-(2-cyanoethyl)-n-cyclohexyl-1-benzothiophene-2-carboxamide Chemical compound S1C2=CC=CC=C2C(Cl)=C1C(=O)N(CCC#N)C1CCCCC1 NIBGOYHSCONGHL-UHFFFAOYSA-N 0.000 claims description 2
KSKRUVPZJQYBJY-UHFFFAOYSA-N 3-chloro-n-(2-cyanoethyl)-n-phenyl-1-benzothiophene-2-carboxamide Chemical compound S1C2=CC=CC=C2C(Cl)=C1C(=O)N(CCC#N)C1=CC=CC=C1 KSKRUVPZJQYBJY-UHFFFAOYSA-N 0.000 claims description 2
LMQVACPEALDOMF-UHFFFAOYSA-N 3-chloro-n-[(1,3-dimethylpyrazol-4-yl)methyl]-5-(4-methoxyphenyl)-n-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(Cl)C(C(=O)N(C)CC=3C(=NN(C)C=3)C)=NN2C(C(F)(F)F)=C1 LMQVACPEALDOMF-UHFFFAOYSA-N 0.000 claims description 2
XPEJXIXVBXJDGH-UHFFFAOYSA-N 3-chloro-n-cyclohexyl-5-(4-methoxyphenyl)-n-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(Cl)C(C(=O)N(C)C3CCCCC3)=NN2C(C(F)(F)F)=C1 XPEJXIXVBXJDGH-UHFFFAOYSA-N 0.000 claims description 2
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 2
HEEDMMBEBQVQSK-UHFFFAOYSA-N 3-cyclohexyl-1-[4-(1h-imidazol-5-yl)piperidin-1-yl]propan-1-one Chemical compound C1CC(C=2N=CNC=2)CCN1C(=O)CCC1CCCCC1 HEEDMMBEBQVQSK-UHFFFAOYSA-N 0.000 claims description 2
NUNQOEASBHTZFI-UHFFFAOYSA-N 3-cyclohexyl-n-(3-phenylpropyl)propanamide Chemical compound C=1C=CC=CC=1CCCNC(=O)CCC1CCCCC1 NUNQOEASBHTZFI-UHFFFAOYSA-N 0.000 claims description 2
VIAZKZSZTPUSTN-UHFFFAOYSA-N 3-cyclopentyl-1-(6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)propan-1-one Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)CCC1CCCC1 VIAZKZSZTPUSTN-UHFFFAOYSA-N 0.000 claims description 2
RSLXYRBJGGKEOQ-UHFFFAOYSA-N 3-cyclopentyl-n-[(4-methylphenyl)methyl]-n-[6-(pyridin-2-ylamino)hexyl]propanamide Chemical compound C1=CC(C)=CC=C1CN(C(=O)CCC1CCCC1)CCCCCCNC1=CC=CC=N1 RSLXYRBJGGKEOQ-UHFFFAOYSA-N 0.000 claims description 2
KPZWEVYTOHWSCX-UHFFFAOYSA-N 3-cyclopentyl-n-[1-[4-(3-cyclopentylpropanoyl)piperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]propanamide Chemical compound C=1C=CC=CC=1CC(C(=O)N1CCN(CC1)C(=O)CCC1CCCC1)NC(=O)CCC1CCCC1 KPZWEVYTOHWSCX-UHFFFAOYSA-N 0.000 claims description 2
DAMPQIDCRXXMOX-UHFFFAOYSA-N 3-cyclopentyl-n-[3-methyl-1-oxo-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)pentan-2-yl]propanamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C(C(C)CC)NC(=O)CCC1CCCC1 DAMPQIDCRXXMOX-UHFFFAOYSA-N 0.000 claims description 2
WGJNCXLHFMFLPI-UHFFFAOYSA-N 3-methoxy-n-(2-methoxyethyl)-n-(2-piperidin-4-ylethyl)-5-(pyridine-2-carbonyl)benzamide Chemical compound C=1C(OC)=CC(C(=O)C=2N=CC=CC=2)=CC=1C(=O)N(CCOC)CCC1CCNCC1 WGJNCXLHFMFLPI-UHFFFAOYSA-N 0.000 claims description 2
JEAJGACHSHBSHS-UHFFFAOYSA-N 3-methoxy-n-(2-methoxyethyl)-n-(piperidin-3-ylmethyl)-5-(pyridine-2-carbonyl)benzamide Chemical compound C=1C(OC)=CC(C(=O)C=2N=CC=CC=2)=CC=1C(=O)N(CCOC)CC1CCCNC1 JEAJGACHSHBSHS-UHFFFAOYSA-N 0.000 claims description 2
SRKVNGUVRVMENY-UHFFFAOYSA-N 3-methoxy-n-(2-oxoazepan-3-yl)-n-(2-piperidin-4-ylethyl)-5-(pyridine-2-carbonyl)benzamide Chemical compound C=1C(OC)=CC(C(=O)N(CCC2CCNCC2)C2C(NCCCC2)=O)=CC=1C(=O)C1=CC=CC=N1 SRKVNGUVRVMENY-UHFFFAOYSA-N 0.000 claims description 2
YRNDALDPZKCGLP-UHFFFAOYSA-N 3-methoxy-n-(oxolan-2-ylmethyl)-n-(2-piperidin-4-ylethyl)-5-(pyridine-2-carbonyl)benzamide Chemical compound C=1C(OC)=CC(C(=O)N(CCC2CCNCC2)CC2OCCC2)=CC=1C(=O)C1=CC=CC=N1 YRNDALDPZKCGLP-UHFFFAOYSA-N 0.000 claims description 2
XXDQRLVBJNMLOG-UHFFFAOYSA-N 3-methoxy-n-[3-(2-oxopyrrolidin-1-yl)propyl]-5-(pyridine-2-carbonyl)benzamide Chemical compound C=1C(OC)=CC(C(=O)NCCCN2C(CCC2)=O)=CC=1C(=O)C1=CC=CC=N1 XXDQRLVBJNMLOG-UHFFFAOYSA-N 0.000 claims description 2
TTXDWKTUIVFROG-UHFFFAOYSA-N 3-methoxy-n-[3-(2-oxopyrrolidin-1-yl)propyl]-n-(2-piperidin-4-ylethyl)-5-(pyridine-2-carbonyl)benzamide Chemical compound C=1C(OC)=CC(C(=O)N(CCCN2C(CCC2)=O)CCC2CCNCC2)=CC=1C(=O)C1=CC=CC=N1 TTXDWKTUIVFROG-UHFFFAOYSA-N 0.000 claims description 2
ZIFMGUQIQKOMTE-UHFFFAOYSA-N 3-methoxy-n-methyl-n-(2-piperidin-4-ylethyl)-5-(pyridine-2-carbonyl)benzamide Chemical compound C=1C(OC)=CC(C(=O)N(C)CCC2CCNCC2)=CC=1C(=O)C1=CC=CC=N1 ZIFMGUQIQKOMTE-UHFFFAOYSA-N 0.000 claims description 2
NVZFJWSRMJTYGR-UHFFFAOYSA-N 3-phenyl-n-(1-phenylpropan-2-yl)propanamide Chemical compound C=1C=CC=CC=1CCC(=O)NC(C)CC1=CC=CC=C1 NVZFJWSRMJTYGR-UHFFFAOYSA-N 0.000 claims description 2
IVQSWGRXIWBWGA-UHFFFAOYSA-N 4-(2,4-dichlorophenoxy)-1-(4-phenylpiperazin-1-yl)butan-1-one Chemical compound ClC1=CC(Cl)=CC=C1OCCCC(=O)N1CCN(C=2C=CC=CC=2)CC1 IVQSWGRXIWBWGA-UHFFFAOYSA-N 0.000 claims description 2
MLHGNSOMRCPHGF-UHFFFAOYSA-N 4-(2,4-dichlorophenoxy)-1-[4-(4-fluorophenyl)piperazin-1-yl]butan-1-one Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)CCCOC=2C(=CC(Cl)=CC=2)Cl)CC1 MLHGNSOMRCPHGF-UHFFFAOYSA-N 0.000 claims description 2
HTFAPKQXWFGTTN-UHFFFAOYSA-N 4-(2,6-dichlorophenyl)sulfanyl-n-[(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)methyl]butanamide Chemical compound CC1(C)C(CC2)CC1C2CNC(=O)CCCSC1=C(Cl)C=CC=C1Cl HTFAPKQXWFGTTN-UHFFFAOYSA-N 0.000 claims description 2
BCOOHAJVMHYSQG-UHFFFAOYSA-N 4-(3,4-dihydro-1h-isoquinoline-2-carbonyl)-1,7,7-trimethyl-3-oxabicyclo[2.2.1]heptan-2-one Chemical compound C1CC2=CC=CC=C2CN1C(=O)C1(OC2=O)CCC2(C)C1(C)C BCOOHAJVMHYSQG-UHFFFAOYSA-N 0.000 claims description 2
ABWBCQMJMOTENL-UHFFFAOYSA-N 4-(3,4-dihydro-2h-quinoline-1-carbonyl)-1,7,7-trimethyl-3-oxabicyclo[2.2.1]heptan-2-one Chemical compound C1CCC2=CC=CC=C2N1C(=O)C1(OC2=O)CCC2(C)C1(C)C ABWBCQMJMOTENL-UHFFFAOYSA-N 0.000 claims description 2
YZQPOZMTRZGJNZ-UHFFFAOYSA-N 4-(4-bromophenyl)-n-[(2-hydroxyphenyl)methyl]-4-oxo-n-(thiophen-2-ylmethyl)butanamide Chemical compound OC1=CC=CC=C1CN(C(=O)CCC(=O)C=1C=CC(Br)=CC=1)CC1=CC=CS1 YZQPOZMTRZGJNZ-UHFFFAOYSA-N 0.000 claims description 2
IGNMXUGQHJGRQL-UHFFFAOYSA-N 4-(4-chloro-2-methylphenoxy)-1-(3,4-dihydro-2h-quinolin-1-yl)butan-1-one Chemical compound CC1=CC(Cl)=CC=C1OCCCC(=O)N1C2=CC=CC=C2CCC1 IGNMXUGQHJGRQL-UHFFFAOYSA-N 0.000 claims description 2
IDADHKJDWBLCBE-UHFFFAOYSA-N 4-(4-methoxy-3-methylphenyl)-n-(2-methylcyclohexyl)butanamide Chemical compound C1=C(C)C(OC)=CC=C1CCCC(=O)NC1C(C)CCCC1 IDADHKJDWBLCBE-UHFFFAOYSA-N 0.000 claims description 2
MPGZGXSWNHOANN-UHFFFAOYSA-N 4-[(3-propoxycarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamoyl]bicyclo[2.2.1]heptane-2-carboxylic acid Chemical compound C(CC)OC(=O)C=1C2=C(SC1NC(=O)C13CC(C(CC1)C3)C(=O)O)CCC2 MPGZGXSWNHOANN-UHFFFAOYSA-N 0.000 claims description 2
DVTPGYSWFFEQDH-UHFFFAOYSA-N 4-[4-[2-[4-(dimethylamino)phenyl]acetyl]piperazin-1-yl]-3-(2-phenylpropylamino)benzamide Chemical compound C=1C=CC=CC=1C(C)CNC1=CC(C(N)=O)=CC=C1N(CC1)CCN1C(=O)CC1=CC=C(N(C)C)C=C1 DVTPGYSWFFEQDH-UHFFFAOYSA-N 0.000 claims description 2
PFIOQDWZNYYLGN-UHFFFAOYSA-N 4-[benzyl(methylsulfonyl)amino]-n-(furan-2-ylmethyl)benzamide Chemical compound C=1C=C(C(=O)NCC=2OC=CC=2)C=CC=1N(S(=O)(=O)C)CC1=CC=CC=C1 PFIOQDWZNYYLGN-UHFFFAOYSA-N 0.000 claims description 2
NJPRATJHCGOAKI-UHFFFAOYSA-N 4-amino-n-(2,3-dihydro-1h-inden-2-yl)-n-[(3-hydroxyphenyl)methyl]-2-(propanoylamino)butanamide Chemical compound C1C2=CC=CC=C2CC1N(C(=O)C(CCN)NC(=O)CC)CC1=CC=CC(O)=C1 NJPRATJHCGOAKI-UHFFFAOYSA-N 0.000 claims description 2
KSMOEHJKKPNNLU-UHFFFAOYSA-N 4-benzoyl-n-methyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C)C(=O)C(C=C1)=CC=C1C(=O)C1=CC=CC=C1 KSMOEHJKKPNNLU-UHFFFAOYSA-N 0.000 claims description 2
RZGYDZODJLKUAS-UHFFFAOYSA-N 4-bromo-1-ethyl-n-(2-methylsulfanylphenyl)pyrazole-3-carboxamide Chemical compound CCN1C=C(Br)C(C(=O)NC=2C(=CC=CC=2)SC)=N1 RZGYDZODJLKUAS-UHFFFAOYSA-N 0.000 claims description 2
SOOIJPNTAQSLKT-UHFFFAOYSA-N 4-bromo-n-[3-(piperidine-1-carbonyl)phenyl]benzamide Chemical compound C1=CC(Br)=CC=C1C(=O)NC1=CC=CC(C(=O)N2CCCCC2)=C1 SOOIJPNTAQSLKT-UHFFFAOYSA-N 0.000 claims description 2
PPOIDZGFAOGDMF-UHFFFAOYSA-N 4-chloro-n-(4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)benzamide Chemical compound CC1(C)C(C2)CCC1(C)C2NC(=O)C1=CC=C(Cl)C=C1 PPOIDZGFAOGDMF-UHFFFAOYSA-N 0.000 claims description 2
LIXSCNLHIZAPAQ-UHFFFAOYSA-N 4-chloro-n-[3-methyl-1-oxo-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)pentan-2-yl]benzamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C(C(C)CC)NC(=O)C1=CC=C(Cl)C=C1 LIXSCNLHIZAPAQ-UHFFFAOYSA-N 0.000 claims description 2
WBRQXZXOGRAPJI-UHFFFAOYSA-N 4-methyl-n-[2-(phenoxazine-10-carbonyl)phenyl]benzenesulfonamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC1=CC=CC=C1C(=O)N1C2=CC=CC=C2OC2=CC=CC=C21 WBRQXZXOGRAPJI-UHFFFAOYSA-N 0.000 claims description 2
AFPFMPNSJWQYPJ-UHFFFAOYSA-N 4-methyl-n-[3-methyl-1-oxo-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)pentan-2-yl]benzamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C(C(C)CC)NC(=O)C1=CC=C(C)C=C1 AFPFMPNSJWQYPJ-UHFFFAOYSA-N 0.000 claims description 2
NWEAQWFUCTVJDI-UHFFFAOYSA-N 4-methyl-n-naphthalen-1-yl-2-phenyl-1,3-thiazole-5-carboxamide Chemical compound S1C(C(=O)NC=2C3=CC=CC=C3C=CC=2)=C(C)N=C1C1=CC=CC=C1 NWEAQWFUCTVJDI-UHFFFAOYSA-N 0.000 claims description 2
LHNSBIUPQDSYIO-UHFFFAOYSA-N 4-tert-butyl-n-cyclooctylbenzamide Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)NC1CCCCCCC1 LHNSBIUPQDSYIO-UHFFFAOYSA-N 0.000 claims description 2
ARVNJCBUCQXYTF-UHFFFAOYSA-N 5,6-dihydrobenzo[b][1]benzazepin-11-yl-(4-fluorophenyl)methanone Chemical compound C1=CC(F)=CC=C1C(=O)N1C2=CC=CC=C2CCC2=CC=CC=C21 ARVNJCBUCQXYTF-UHFFFAOYSA-N 0.000 claims description 2
KLWVLLPTXFKYLW-UHFFFAOYSA-N 5-(2,6-dichlorophenyl)sulfanyl-n-(naphthalen-1-ylmethyl)pentanamide Chemical compound ClC1=CC=CC(Cl)=C1SCCCCC(=O)NCC1=CC=CC2=CC=CC=C12 KLWVLLPTXFKYLW-UHFFFAOYSA-N 0.000 claims description 2
OADYUHNMWNRALE-UHFFFAOYSA-N 5-(2,6-dichlorophenyl)sulfanyl-n-[2-[3-(trifluoromethyl)phenyl]ethyl]pentanamide Chemical compound FC(F)(F)C1=CC=CC(CCNC(=O)CCCCSC=2C(=CC=CC=2Cl)Cl)=C1 OADYUHNMWNRALE-UHFFFAOYSA-N 0.000 claims description 2
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IBUSJDQPKCWIEP-UHFFFAOYSA-N [3-chloro-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=NN(C(=CC(=N2)C=3SC=CC=3)C(F)(F)F)C2=C1Cl IBUSJDQPKCWIEP-UHFFFAOYSA-N 0.000 claims description 2
AUPFDHLAVYZHJL-UHFFFAOYSA-N [3-chloro-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-phenylpiperazin-1-yl)methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C(Cl)C=1C(=O)N(CC1)CCN1C1=CC=CC=C1 AUPFDHLAVYZHJL-UHFFFAOYSA-N 0.000 claims description 2
CUONJIDMEIRDDS-UHFFFAOYSA-N [3-chloro-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-morpholin-4-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C(Cl)C=1C(=O)N1CCOCC1 CUONJIDMEIRDDS-UHFFFAOYSA-N 0.000 claims description 2
WUXPNULLVNWTND-UHFFFAOYSA-N [3-chloro-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C(Cl)C=1C(=O)N1CCCCC1 WUXPNULLVNWTND-UHFFFAOYSA-N 0.000 claims description 2
MLAOSPGUZDRVNW-UHFFFAOYSA-N [4-(1h-imidazol-5-yl)piperidin-1-yl]-(4-pentylphenyl)methanone Chemical compound C1=CC(CCCCC)=CC=C1C(=O)N1CCC(C=2N=CNC=2)CC1 MLAOSPGUZDRVNW-UHFFFAOYSA-N 0.000 claims description 2
ABFRJGNQGQJOAT-UHFFFAOYSA-N [4-(2,3-dimethylphenyl)piperazin-1-yl]-(2-methylphenyl)methanone Chemical compound CC1=CC=CC(N2CCN(CC2)C(=O)C=2C(=CC=CC=2)C)=C1C ABFRJGNQGQJOAT-UHFFFAOYSA-N 0.000 claims description 2
KTOGWFSKGNVKMK-UHFFFAOYSA-N [4-(2,3-dimethylphenyl)piperazin-1-yl]-(3-methoxyphenyl)methanone Chemical compound COC1=CC=CC(C(=O)N2CCN(CC2)C=2C(=C(C)C=CC=2)C)=C1 KTOGWFSKGNVKMK-UHFFFAOYSA-N 0.000 claims description 2
GITJXPAWMDCFHF-UHFFFAOYSA-N [4-(2,5-dimethylpyrrol-1-yl)phenyl]-(4-methylpiperidin-1-yl)methanone Chemical compound C1CC(C)CCN1C(=O)C1=CC=C(N2C(=CC=C2C)C)C=C1 GITJXPAWMDCFHF-UHFFFAOYSA-N 0.000 claims description 2
VGLSLVIKCNISMT-UHFFFAOYSA-N [4-(2-chloro-6-nitrophenoxy)phenyl]-piperidin-1-ylmethanone Chemical compound [O-][N+](=O)C1=CC=CC(Cl)=C1OC1=CC=C(C(=O)N2CCCCC2)C=C1 VGLSLVIKCNISMT-UHFFFAOYSA-N 0.000 claims description 2
RIHMZRJSBOXKJG-UHFFFAOYSA-N [4-(2-chloro-6-nitrophenyl)piperazin-1-yl]-(4-methoxyphenyl)methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1CCN(C=2C(=CC=CC=2Cl)[N+]([O-])=O)CC1 RIHMZRJSBOXKJG-UHFFFAOYSA-N 0.000 claims description 2
YSIGHMXTVPOKOG-UHFFFAOYSA-N [4-(2-chloro-6-nitrophenyl)piperazin-1-yl]-(4-methylphenyl)methanone Chemical compound C1=CC(C)=CC=C1C(=O)N1CCN(C=2C(=CC=CC=2Cl)[N+]([O-])=O)CC1 YSIGHMXTVPOKOG-UHFFFAOYSA-N 0.000 claims description 2
AJFXSFNLQXVRRM-UHFFFAOYSA-N [4-(2-chlorophenyl)piperazin-1-yl]-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=CC=1C(=O)N(CC1)CCN1C1=CC=CC=C1Cl AJFXSFNLQXVRRM-UHFFFAOYSA-N 0.000 claims description 2
WTPUHJGRHJWNSZ-UHFFFAOYSA-N [4-(2-methoxyphenyl)piperazin-1-yl]-pyrazolo[1,5-a]pyrimidin-3-ylmethanone Chemical compound COC1=CC=CC=C1N1CCN(C(=O)C2=C3N=CC=CN3N=C2)CC1 WTPUHJGRHJWNSZ-UHFFFAOYSA-N 0.000 claims description 2
ZVJVFOPIJNWPMV-UHFFFAOYSA-N [4-(3,4-dihydro-2h-quinoline-1-carbonyl)phenyl] acetate Chemical compound C1=CC(OC(=O)C)=CC=C1C(=O)N1C2=CC=CC=C2CCC1 ZVJVFOPIJNWPMV-UHFFFAOYSA-N 0.000 claims description 2
LHZYREUROAQJCW-UHFFFAOYSA-N [4-(3,5-dimethylpiperidine-1-carbonyl)phenyl] acetate Chemical compound C1C(C)CC(C)CN1C(=O)C1=CC=C(OC(C)=O)C=C1 LHZYREUROAQJCW-UHFFFAOYSA-N 0.000 claims description 2
VFHMMKKEAMZKKJ-UHFFFAOYSA-N [4-(3,5-dinitrophenoxy)phenyl]-(2-ethylpiperidin-1-yl)methanone Chemical compound CCC1CCCCN1C(=O)C(C=C1)=CC=C1OC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1 VFHMMKKEAMZKKJ-UHFFFAOYSA-N 0.000 claims description 2
QTJKRZCTNZGLKQ-UHFFFAOYSA-N [4-(3-chlorophenyl)piperazin-1-yl]-[5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(C)=CC=C1C1=NC2=C(C(=O)N3CCN(CC3)C=3C=C(Cl)C=CC=3)C=NN2C(C(F)(F)F)=C1 QTJKRZCTNZGLKQ-UHFFFAOYSA-N 0.000 claims description 2
PRVPUYZTKITVQM-UHFFFAOYSA-N [4-(4-benzylpiperidine-1-carbonyl)phenyl] acetate Chemical compound C1=CC(OC(=O)C)=CC=C1C(=O)N1CCC(CC=2C=CC=CC=2)CC1 PRVPUYZTKITVQM-UHFFFAOYSA-N 0.000 claims description 2
SZQAZKPTPIQYQP-UHFFFAOYSA-N [4-(4-bromophenyl)sulfonylpiperazin-1-yl]-(furan-2-yl)methanone Chemical compound C1=CC(Br)=CC=C1S(=O)(=O)N1CCN(C(=O)C=2OC=CC=2)CC1 SZQAZKPTPIQYQP-UHFFFAOYSA-N 0.000 claims description 2
LLHWIRXTBXXNRU-UHFFFAOYSA-N [4-(4-chlorophenyl)piperazin-1-yl]-[7-(difluoromethyl)-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CCN(CC3)C=3C=CC(Cl)=CC=3)C=NN2C(C(F)F)=C1 LLHWIRXTBXXNRU-UHFFFAOYSA-N 0.000 claims description 2
ASFLTSMNCCHSLI-UHFFFAOYSA-N [4-(4-fluorophenyl)piperazin-1-yl]-(7-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)methanone Chemical compound N=1N2C(C)=CC(C=3C=CC=CC=3)=NC2=CC=1C(=O)N(CC1)CCN1C1=CC=C(F)C=C1 ASFLTSMNCCHSLI-UHFFFAOYSA-N 0.000 claims description 2
TXVZYSSZZWZFBX-UHFFFAOYSA-N [4-(4-fluorophenyl)piperazin-1-yl]-[5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(C)=CC=C1C1=NC2=CC(C(=O)N3CCN(CC3)C=3C=CC(F)=CC=3)=NN2C(C(F)(F)F)=C1 TXVZYSSZZWZFBX-UHFFFAOYSA-N 0.000 claims description 2
IFQXIUBJEQMLBU-UHFFFAOYSA-N [4-(4-fluorophenyl)piperazin-1-yl]-[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)C2=NN3C(=CC(=NC3=C2)C=2C=CC=CC=2)C(F)(F)F)CC1 IFQXIUBJEQMLBU-UHFFFAOYSA-N 0.000 claims description 2
GOHLNKFRUYWBQB-UHFFFAOYSA-N [4-(4-fluorophenyl)piperazin-1-yl]-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)C2=C3N=C(C=C(N3N=C2)C(F)(F)F)C=2SC=CC=2)CC1 GOHLNKFRUYWBQB-UHFFFAOYSA-N 0.000 claims description 2
JTHNOLKHHKCTPL-UHFFFAOYSA-N [4-(4-methylpiperidine-1-carbonyl)phenyl] acetate Chemical compound C1CC(C)CCN1C(=O)C1=CC=C(OC(C)=O)C=C1 JTHNOLKHHKCTPL-UHFFFAOYSA-N 0.000 claims description 2
DRTKTDQTTOPSAQ-UHFFFAOYSA-N [4-(adamantane-1-carbonylamino)-2,6-dimethylpyridin-3-yl] adamantane-1-carboxylate Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)OC1=C(NC(=O)C23CC4CC(CC(C4)C2)C3)C=C(C)N=C1C DRTKTDQTTOPSAQ-UHFFFAOYSA-N 0.000 claims description 2
ITMCBJAQMJMNNC-UHFFFAOYSA-N [4-(adamantane-1-carbonylamino)-2-ethyl-6-methylpyridin-3-yl] adamantane-1-carboxylate Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)OC1=C(NC(=O)C23CC4CC(CC(C4)C2)C3)C=C(C)N=C1CC ITMCBJAQMJMNNC-UHFFFAOYSA-N 0.000 claims description 2
WGAADDNVYHZGNK-UHFFFAOYSA-N [4-(azepane-1-carbonyl)phenyl] acetate Chemical compound C1=CC(OC(=O)C)=CC=C1C(=O)N1CCCCCC1 WGAADDNVYHZGNK-UHFFFAOYSA-N 0.000 claims description 2
BNQBIMPSYNRLDO-UHFFFAOYSA-N [4-[(2-methoxynaphthalen-1-yl)methyl]piperazin-1-yl]-(4-methoxyphenyl)methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1CCN(CC=2C3=CC=CC=C3C=CC=2OC)CC1 BNQBIMPSYNRLDO-UHFFFAOYSA-N 0.000 claims description 2
QOMHEACWNDKGIP-UHFFFAOYSA-N [4-[(2-nitrophenyl)methyl]piperidin-1-yl]-phenylmethanone Chemical compound [O-][N+](=O)C1=CC=CC=C1CC1CCN(C(=O)C=2C=CC=CC=2)CC1 QOMHEACWNDKGIP-UHFFFAOYSA-N 0.000 claims description 2
GUFOXFGOAZJHND-UHFFFAOYSA-N [4-[(4-chlorophenyl)sulfanylmethyl]phenyl]-pyrrolidin-1-ylmethanone Chemical compound C1=CC(Cl)=CC=C1SCC1=CC=C(C(=O)N2CCCC2)C=C1 GUFOXFGOAZJHND-UHFFFAOYSA-N 0.000 claims description 2
YXSKXLLBOGENMA-UHFFFAOYSA-N [4-[(4-ethoxyphenoxy)methyl]phenyl]-(4-methylpiperidin-1-yl)methanone Chemical compound C1=CC(OCC)=CC=C1OCC1=CC=C(C(=O)N2CCC(C)CC2)C=C1 YXSKXLLBOGENMA-UHFFFAOYSA-N 0.000 claims description 2
JXGWQAJHERXXHX-UHFFFAOYSA-N [4-[(4-nitrophenyl)methyl]piperidin-1-yl]-phenylmethanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1CC1CCN(C(=O)C=2C=CC=CC=2)CC1 JXGWQAJHERXXHX-UHFFFAOYSA-N 0.000 claims description 2
CUMNVZZYZWYMCG-UHFFFAOYSA-N [4-[3-bromo-5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]piperazin-1-yl]-phenylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3OC=CC=3)=NC2=C(Br)C=1C(=O)N(CC1)CCN1C(=O)C1=CC=CC=C1 CUMNVZZYZWYMCG-UHFFFAOYSA-N 0.000 claims description 2
XLKHWLQFNIVDQD-UHFFFAOYSA-N [4-[3-chloro-5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]piperazin-1-yl]-phenylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Cl)=CC=3)=NC2=C(Cl)C=1C(=O)N(CC1)CCN1C(=O)C1=CC=CC=C1 XLKHWLQFNIVDQD-UHFFFAOYSA-N 0.000 claims description 2
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GDWYKYYJFQOMCO-UHFFFAOYSA-N [4-[7-(difluoromethyl)-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]piperazin-1-yl]-(furan-2-yl)methanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CCN(CC3)C(=O)C=3OC=CC=3)C=NN2C(C(F)F)=C1 GDWYKYYJFQOMCO-UHFFFAOYSA-N 0.000 claims description 2
CJLUNEBNAGOIAL-UHFFFAOYSA-N [4-[7-(difluoromethyl)-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl]piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone Chemical compound CN1N=CC=C1C(=O)N1CCN(C(=O)C2=C3N=C(C=C(N3N=C2)C(F)F)C=2C=CC=CC=2)CC1 CJLUNEBNAGOIAL-UHFFFAOYSA-N 0.000 claims description 2
CHKYSZUKDIJJKQ-UHFFFAOYSA-N [5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-benzylpiperazin-1-yl)methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=CC=1C(=O)N(CC1)CCN1CC1=CC=CC=C1 CHKYSZUKDIJJKQ-UHFFFAOYSA-N 0.000 claims description 2
UBIDLTHYPKQOQS-UHFFFAOYSA-N [5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=NN2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=C1 UBIDLTHYPKQOQS-UHFFFAOYSA-N 0.000 claims description 2
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LCWGYHMKPRJELO-UHFFFAOYSA-N [5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=CC=1C(=O)N1CCCCC1 LCWGYHMKPRJELO-UHFFFAOYSA-N 0.000 claims description 2
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JKZHOWWEERFJKQ-UHFFFAOYSA-N [5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=C2N=C(C=3C=C4OCOC4=CC=3)C=C(C(F)(F)F)N2N=C1 JKZHOWWEERFJKQ-UHFFFAOYSA-N 0.000 claims description 2
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AFZRYAVTIGZZPQ-UHFFFAOYSA-N [5-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-thiomorpholin-4-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=C(Cl)C(Cl)=CC=3)=NC2=CC=1C(=O)N1CCSCC1 AFZRYAVTIGZZPQ-UHFFFAOYSA-N 0.000 claims description 2
GWWZOBANJMBKBL-UHFFFAOYSA-N [5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-morpholin-4-ylmethanone Chemical compound C1=C(OC)C(OC)=CC=C1C1=NC2=CC(C(=O)N3CCOCC3)=NN2C(C(F)(F)F)=C1 GWWZOBANJMBKBL-UHFFFAOYSA-N 0.000 claims description 2
KVMGTIZKUHGYEG-UHFFFAOYSA-N [5-(4-bromophenyl)-3-chloro-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=NN(C(=CC(=N2)C=3C=CC(Br)=CC=3)C(F)(F)F)C2=C1Cl KVMGTIZKUHGYEG-UHFFFAOYSA-N 0.000 claims description 2
QNNKXSYOYPYKBQ-UHFFFAOYSA-N [5-(4-bromophenyl)-3-chloro-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=C(Cl)C=1C(=O)N1CCCCC1 QNNKXSYOYPYKBQ-UHFFFAOYSA-N 0.000 claims description 2
PBXSLOGSIXUDKK-UHFFFAOYSA-N [5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-morpholin-4-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=CC=1C(=O)N1CCOCC1 PBXSLOGSIXUDKK-UHFFFAOYSA-N 0.000 claims description 2
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NRTQQAXBRLKZJG-UHFFFAOYSA-N [5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-pyrrolidin-1-ylmethanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=CC=1C(=O)N1CCCC1 NRTQQAXBRLKZJG-UHFFFAOYSA-N 0.000 claims description 2
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SDDFDNWYMKOYAN-UHFFFAOYSA-N [5-(4-ethoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidin-2-yl]-(4-phenylpiperazin-1-yl)methanone Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC(C(=O)N3CCN(CC3)C=3C=CC=CC=3)=NN2C(C)=C1 SDDFDNWYMKOYAN-UHFFFAOYSA-N 0.000 claims description 2
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SSDUMWLLOFTZSK-UHFFFAOYSA-N [5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-morpholin-4-ylmethanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC(C(=O)N3CCOCC3)=NN2C(C(F)(F)F)=C1 SSDUMWLLOFTZSK-UHFFFAOYSA-N 0.000 claims description 2
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CKRPSXRCWPBYRL-UHFFFAOYSA-N [5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1=NC2=CC(C(=O)N3CCCCC3)=NN2C(C(F)(F)F)=C1 CKRPSXRCWPBYRL-UHFFFAOYSA-N 0.000 claims description 2
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RIZHOCSVILARCM-UHFFFAOYSA-N [5-[(2,5-dichlorophenoxy)methyl]furan-2-yl]-thiomorpholin-4-ylmethanone Chemical compound ClC1=CC=C(Cl)C(OCC=2OC(=CC=2)C(=O)N2CCSCC2)=C1 RIZHOCSVILARCM-UHFFFAOYSA-N 0.000 claims description 2
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BKAJXGHQARPTHL-UHFFFAOYSA-N [5-[(2-bromophenoxy)methyl]furan-2-yl]-(2-methylpiperidin-1-yl)methanone Chemical compound CC1CCCCN1C(=O)C(O1)=CC=C1COC1=CC=CC=C1Br BKAJXGHQARPTHL-UHFFFAOYSA-N 0.000 claims description 2
RNGLCZFJHZQHJY-UHFFFAOYSA-N [5-[(2-bromophenoxy)methyl]furan-2-yl]-(6-fluoro-2-methyl-3,4-dihydro-2h-quinolin-1-yl)methanone Chemical compound CC1CCC2=CC(F)=CC=C2N1C(=O)C(O1)=CC=C1COC1=CC=CC=C1Br RNGLCZFJHZQHJY-UHFFFAOYSA-N 0.000 claims description 2
KFAGUWAWGZOSNX-UHFFFAOYSA-N [5-[(2-chlorophenoxy)methyl]furan-2-yl]-(3-methylpiperidin-1-yl)methanone Chemical compound C1C(C)CCCN1C(=O)C(O1)=CC=C1COC1=CC=CC=C1Cl KFAGUWAWGZOSNX-UHFFFAOYSA-N 0.000 claims description 2
HROOUULWXOGBLV-UHFFFAOYSA-N [5-[(2-chlorophenoxy)methyl]furan-2-yl]-(4-methylpiperidin-1-yl)methanone Chemical compound C1CC(C)CCN1C(=O)C(O1)=CC=C1COC1=CC=CC=C1Cl HROOUULWXOGBLV-UHFFFAOYSA-N 0.000 claims description 2
BGDRDPZYQPPGIG-UHFFFAOYSA-N [5-[(2-methoxy-4-propylphenoxy)methyl]furan-2-yl]-(3-methylpiperidin-1-yl)methanone Chemical compound COC1=CC(CCC)=CC=C1OCC1=CC=C(C(=O)N2CC(C)CCC2)O1 BGDRDPZYQPPGIG-UHFFFAOYSA-N 0.000 claims description 2
CYCGAWIOXBJIAR-UHFFFAOYSA-N [5-[(3-chlorophenoxy)methyl]furan-2-yl]-piperidin-1-ylmethanone Chemical compound ClC1=CC=CC(OCC=2OC(=CC=2)C(=O)N2CCCCC2)=C1 CYCGAWIOXBJIAR-UHFFFAOYSA-N 0.000 claims description 2
BFQYFMATBVTFHP-UHFFFAOYSA-N [5-[(4-ethoxyphenoxy)methyl]furan-2-yl]-(4-methylpiperidin-1-yl)methanone Chemical compound C1=CC(OCC)=CC=C1OCC1=CC=C(C(=O)N2CCC(C)CC2)O1 BFQYFMATBVTFHP-UHFFFAOYSA-N 0.000 claims description 2
WUYBEZUGTUGNQF-UHFFFAOYSA-N [5-[(4-methyl-2-nitrophenoxy)methyl]furan-2-yl]-thiomorpholin-4-ylmethanone Chemical compound [O-][N+](=O)C1=CC(C)=CC=C1OCC1=CC=C(C(=O)N2CCSCC2)O1 WUYBEZUGTUGNQF-UHFFFAOYSA-N 0.000 claims description 2
XIQSFQGQOOFIDR-UHFFFAOYSA-N [7-(difluoromethyl)-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(2-ethylimidazol-1-yl)methanone Chemical compound CCC1=NC=CN1C(=O)C1=C2N=C(C=3C=CC(OC)=CC=3)C=C(C(F)F)N2N=C1 XIQSFQGQOOFIDR-UHFFFAOYSA-N 0.000 claims description 2
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PRGUGWPVKZIZPE-UHFFFAOYSA-N [7-(difluoromethyl)-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-morpholin-4-ylmethanone Chemical compound C1=CC(OC)=CC=C1C1=NC2=C(C(=O)N3CCOCC3)C=NN2C(C(F)F)=C1 PRGUGWPVKZIZPE-UHFFFAOYSA-N 0.000 claims description 2
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ABRBJPZAPLWUTA-UHFFFAOYSA-N [7-(difluoromethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(4-ethylpiperazin-1-yl)methanone Chemical compound C1CN(CC)CCN1C(=O)C1=C2N=C(C=3C=CC(C)=CC=3)C=C(C(F)F)N2N=C1 ABRBJPZAPLWUTA-UHFFFAOYSA-N 0.000 claims description 2
IJWXSKWIASJQNF-UHFFFAOYSA-N [7-(difluoromethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(4-pyridin-2-ylpiperazin-1-yl)methanone Chemical compound C1=CC(C)=CC=C1C1=NC2=C(C(=O)N3CCN(CC3)C=3N=CC=CC=3)C=NN2C(C(F)F)=C1 IJWXSKWIASJQNF-UHFFFAOYSA-N 0.000 claims description 2
BLABIJIFXATKBP-UHFFFAOYSA-N [7-(difluoromethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-morpholin-4-ylmethanone Chemical compound C1=CC(C)=CC=C1C1=NC2=C(C(=O)N3CCOCC3)C=NN2C(C(F)F)=C1 BLABIJIFXATKBP-UHFFFAOYSA-N 0.000 claims description 2
AAHGCCGJWBYLKR-UHFFFAOYSA-N [7-(difluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidin-3-yl]-piperidin-1-ylmethanone Chemical compound C=12N=C(C)C=C(C(F)F)N2N=CC=1C(=O)N1CCCCC1 AAHGCCGJWBYLKR-UHFFFAOYSA-N 0.000 claims description 2
ISTMZTNEGHDWRR-UHFFFAOYSA-N [7-(difluoromethyl)-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl]-(2-ethylimidazol-1-yl)methanone Chemical compound CCC1=NC=CN1C(=O)C1=C2N=C(C=3C=CC=CC=3)C=C(C(F)F)N2N=C1 ISTMZTNEGHDWRR-UHFFFAOYSA-N 0.000 claims description 2
BQQDBGNNCTVICJ-UHFFFAOYSA-N [7-(difluoromethyl)-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl]-(3,4-dihydro-1h-isoquinolin-2-yl)methanone Chemical compound N=1C2=C(C(=O)N3CC4=CC=CC=C4CC3)C=NN2C(C(F)F)=CC=1C1=CC=CC=C1 BQQDBGNNCTVICJ-UHFFFAOYSA-N 0.000 claims description 2
SQXUMPJPLQHUGH-UHFFFAOYSA-N [7-(difluoromethyl)-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl]-thiomorpholin-4-ylmethanone Chemical compound C1=NN2C(C(F)F)=CC(C=3C=CC=CC=3)=NC2=C1C(=O)N1CCSCC1 SQXUMPJPLQHUGH-UHFFFAOYSA-N 0.000 claims description 2
125000005325 aryloxy aryl group Chemical group 0.000 claims description 2
JUZYPZJSFMXTBR-UHFFFAOYSA-N azepan-1-yl-(3,5-dibromophenyl)methanone Chemical compound BrC1=CC(Br)=CC(C(=O)N2CCCCCC2)=C1 JUZYPZJSFMXTBR-UHFFFAOYSA-N 0.000 claims description 2
CCQVGTWMJWHRSK-UHFFFAOYSA-N azepan-1-yl-(3,5-dichlorophenyl)methanone Chemical compound ClC1=CC(Cl)=CC(C(=O)N2CCCCCC2)=C1 CCQVGTWMJWHRSK-UHFFFAOYSA-N 0.000 claims description 2
HZXUZPVUQDNHJL-UHFFFAOYSA-N azepan-1-yl-(3,6-dichloro-1-benzothiophen-2-yl)methanone Chemical compound S1C2=CC(Cl)=CC=C2C(Cl)=C1C(=O)N1CCCCCC1 HZXUZPVUQDNHJL-UHFFFAOYSA-N 0.000 claims description 2
CGZXSXDQZDQOGZ-UHFFFAOYSA-N azepan-1-yl-(3-chloro-6-methyl-1-benzothiophen-2-yl)methanone Chemical compound S1C2=CC(C)=CC=C2C(Cl)=C1C(=O)N1CCCCCC1 CGZXSXDQZDQOGZ-UHFFFAOYSA-N 0.000 claims description 2
ROFXWDXZMUQQSV-UHFFFAOYSA-N azepan-1-yl-(4-phenylphenyl)methanone Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(=O)N1CCCCCC1 ROFXWDXZMUQQSV-UHFFFAOYSA-N 0.000 claims description 2
QXWBSHGXUMFKBF-UHFFFAOYSA-N azepan-1-yl-(5,7-diphenylpyrazolo[1,5-a]pyrimidin-2-yl)methanone Chemical compound C1=C2N=C(C=3C=CC=CC=3)C=C(C=3C=CC=CC=3)N2N=C1C(=O)N1CCCCCC1 QXWBSHGXUMFKBF-UHFFFAOYSA-N 0.000 claims description 2
XJQOINKSTXAMSQ-UHFFFAOYSA-N azepan-1-yl-(5-tert-butyl-1h-pyrazol-3-yl)methanone Chemical compound N1N=C(C(C)(C)C)C=C1C(=O)N1CCCCCC1 XJQOINKSTXAMSQ-UHFFFAOYSA-N 0.000 claims description 2
MFUXQBMFODKYNP-UHFFFAOYSA-N azepan-1-yl-[3-[(4-ethoxyphenoxy)methyl]phenyl]methanone Chemical compound C1=CC(OCC)=CC=C1OCC1=CC=CC(C(=O)N2CCCCCC2)=C1 MFUXQBMFODKYNP-UHFFFAOYSA-N 0.000 claims description 2
SAAZNLRJHODSLQ-UHFFFAOYSA-N azepan-1-yl-[3-bromo-5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=C(Br)C=1C(=O)N1CCCCCC1 SAAZNLRJHODSLQ-UHFFFAOYSA-N 0.000 claims description 2
MLPAHBDJWVFTSV-UHFFFAOYSA-N azepan-1-yl-[3-chloro-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=C(OC)C(OC)=CC=C1C1=NC2=C(Cl)C(C(=O)N3CCCCCC3)=NN2C(C(F)(F)F)=C1 MLPAHBDJWVFTSV-UHFFFAOYSA-N 0.000 claims description 2
QUDHGQRQAPWFLO-UHFFFAOYSA-N azepan-1-yl-[3-chloro-5-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Cl)=CC=3)=NC2=C(Cl)C=1C(=O)N1CCCCCC1 QUDHGQRQAPWFLO-UHFFFAOYSA-N 0.000 claims description 2
PQOHXHNCHGUWNG-UHFFFAOYSA-N azepan-1-yl-[3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(C)=CC=C1C1=NC2=C(Cl)C(C(=O)N3CCCCCC3)=NN2C(C(F)(F)F)=C1 PQOHXHNCHGUWNG-UHFFFAOYSA-N 0.000 claims description 2
OWCCNJVYQXMRFZ-UHFFFAOYSA-N azepan-1-yl-[3-chloro-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC=CC=3)=NC2=C(Cl)C=1C(=O)N1CCCCCC1 OWCCNJVYQXMRFZ-UHFFFAOYSA-N 0.000 claims description 2
GWUIWEXADFUPMK-UHFFFAOYSA-N azepan-1-yl-[4-[(2-chlorophenoxy)methyl]phenyl]methanone Chemical compound ClC1=CC=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)C=C1 GWUIWEXADFUPMK-UHFFFAOYSA-N 0.000 claims description 2
UCPQJIKFXBCUQB-UHFFFAOYSA-N azepan-1-yl-[4-[(4-chlorophenyl)sulfanylmethyl]phenyl]methanone Chemical compound C1=CC(Cl)=CC=C1SCC1=CC=C(C(=O)N2CCCCCC2)C=C1 UCPQJIKFXBCUQB-UHFFFAOYSA-N 0.000 claims description 2
AEQANCUBKVBNNE-UHFFFAOYSA-N azepan-1-yl-[5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=CC=1C(=O)N1CCCCCC1 AEQANCUBKVBNNE-UHFFFAOYSA-N 0.000 claims description 2
FBPKITYGTZFHKY-UHFFFAOYSA-N azepan-1-yl-[5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=C1C(=O)N1CCCCCC1 FBPKITYGTZFHKY-UHFFFAOYSA-N 0.000 claims description 2
SOENLCFYVWXZOE-UHFFFAOYSA-N azepan-1-yl-[5-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=C(Cl)C(Cl)=CC=3)=NC2=CC=1C(=O)N1CCCCCC1 SOENLCFYVWXZOE-UHFFFAOYSA-N 0.000 claims description 2
QRJRQZMDTJHECQ-UHFFFAOYSA-N azepan-1-yl-[5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=C(OC)C(OC)=CC=C1C1=NC2=CC(C(=O)N3CCCCCC3)=NN2C(C(F)(F)F)=C1 QRJRQZMDTJHECQ-UHFFFAOYSA-N 0.000 claims description 2
BCRNBXQKTYGNRY-UHFFFAOYSA-N azepan-1-yl-[5-(4-bromophenyl)-3-chloro-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=C(Cl)C=1C(=O)N1CCCCCC1 BCRNBXQKTYGNRY-UHFFFAOYSA-N 0.000 claims description 2
FHZLMVBPLCIKJI-UHFFFAOYSA-N azepan-1-yl-[5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=CC=1C(=O)N1CCCCCC1 FHZLMVBPLCIKJI-UHFFFAOYSA-N 0.000 claims description 2
JTBLLIOAQLCDTO-UHFFFAOYSA-N azepan-1-yl-[5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3C=CC(Br)=CC=3)=NC2=C1C(=O)N1CCCCCC1 JTBLLIOAQLCDTO-UHFFFAOYSA-N 0.000 claims description 2
YRCWUMHRRJVNFB-UHFFFAOYSA-N azepan-1-yl-[5-(4-chlorophenyl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound CC1=NN2C(C(F)(F)F)=CC(C=3C=CC(Cl)=CC=3)=NC2=C1C(=O)N1CCCCCC1 YRCWUMHRRJVNFB-UHFFFAOYSA-N 0.000 claims description 2
ZPRMVXIWDAGRNB-UHFFFAOYSA-N azepan-1-yl-[5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC(F)=CC=C1C1=NC2=CC(C(=O)N3CCCCCC3)=NN2C(C(F)(F)F)=C1 ZPRMVXIWDAGRNB-UHFFFAOYSA-N 0.000 claims description 2
WIPKOJFJCNOQLA-UHFFFAOYSA-N azepan-1-yl-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1=NC2=CC(C(=O)N3CCCCCC3)=NN2C(C(F)(F)F)=C1 WIPKOJFJCNOQLA-UHFFFAOYSA-N 0.000 claims description 2
SOCDFQDHAGVMQG-UHFFFAOYSA-N azepan-1-yl-[5-(furan-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3OC=CC=3)=NC2=C1C(=O)N1CCCCCC1 SOCDFQDHAGVMQG-UHFFFAOYSA-N 0.000 claims description 2
KAKWSCYOEPHRJT-UHFFFAOYSA-N azepan-1-yl-[5-[(2,4-dichlorophenoxy)methyl]furan-2-yl]methanone Chemical compound ClC1=CC(Cl)=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)O1 KAKWSCYOEPHRJT-UHFFFAOYSA-N 0.000 claims description 2
MKRVVBQAJLOUNY-UHFFFAOYSA-N azepan-1-yl-[5-[(2-chlorophenoxy)methyl]furan-2-yl]methanone Chemical compound ClC1=CC=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)O1 MKRVVBQAJLOUNY-UHFFFAOYSA-N 0.000 claims description 2
IJINABFBHKFXNV-UHFFFAOYSA-N azepan-1-yl-[5-[(2-nitrophenoxy)methyl]furan-2-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1=CC=C(C(=O)N2CCCCCC2)O1 IJINABFBHKFXNV-UHFFFAOYSA-N 0.000 claims description 2
ZHJBYQGKWYMMGA-UHFFFAOYSA-N azepan-1-yl-[5-[(4-chloro-3,5-dimethylpyrazol-1-yl)methyl]furan-2-yl]methanone Chemical compound CC1=C(Cl)C(C)=NN1CC1=CC=C(C(=O)N2CCCCCC2)O1 ZHJBYQGKWYMMGA-UHFFFAOYSA-N 0.000 claims description 2
UUFHDHOBZLCKTG-UHFFFAOYSA-N azepan-1-yl-[5-[(4-chloro-5-methyl-3-nitropyrazol-1-yl)methyl]furan-2-yl]methanone Chemical compound CC1=C(Cl)C([N+]([O-])=O)=NN1CC1=CC=C(C(=O)N2CCCCCC2)O1 UUFHDHOBZLCKTG-UHFFFAOYSA-N 0.000 claims description 2
ILBDOFYZWPFZAY-UHFFFAOYSA-N azepan-1-yl-[5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)F)=CC(C3CC3)=NC2=C1C(=O)N1CCCCCC1 ILBDOFYZWPFZAY-UHFFFAOYSA-N 0.000 claims description 2
KPUHGPXZPOFCLH-UHFFFAOYSA-N azepan-1-yl-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=C1C(=O)N1CCCCCC1 KPUHGPXZPOFCLH-UHFFFAOYSA-N 0.000 claims description 2
WHFSDGUBUCEVTA-UHFFFAOYSA-N azepan-1-yl-[7-(difluoromethyl)-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)F)=CC(C=3C=CC=CC=3)=NC2=C1C(=O)N1CCCCCC1 WHFSDGUBUCEVTA-UHFFFAOYSA-N 0.000 claims description 2
QLAXSXVMBJRQCP-UHFFFAOYSA-N benzyl 2-[2-[(3,4-dimethoxyphenyl)carbamoyl]piperidin-1-yl]acetate;oxalic acid Chemical compound OC(=O)C(O)=O.C1=C(OC)C(OC)=CC=C1NC(=O)C1N(CC(=O)OCC=2C=CC=CC=2)CCCC1 QLAXSXVMBJRQCP-UHFFFAOYSA-N 0.000 claims description 2
VIZHYOQUNVSIAV-UHFFFAOYSA-N butyl 2-(n-benzoyl-3-chloro-4-fluoroanilino)propanoate Chemical compound C=1C=C(F)C(Cl)=CC=1N(C(C)C(=O)OCCCC)C(=O)C1=CC=CC=C1 VIZHYOQUNVSIAV-UHFFFAOYSA-N 0.000 claims description 2
ATSAAFXONHKPNI-UHFFFAOYSA-N chembl1409931 Chemical compound OC1=CC=CC=C1C(O1)=NN=C1SCC(=O)N1CCCCC1 ATSAAFXONHKPNI-UHFFFAOYSA-N 0.000 claims description 2
238000006243 chemical reaction Methods 0.000 claims description 2
VXVVUHQULXCUPF-UHFFFAOYSA-N cycloheptanamine Chemical compound NC1CCCCCC1 VXVVUHQULXCUPF-UHFFFAOYSA-N 0.000 claims description 2
PBGGNZZGJIKBMJ-UHFFFAOYSA-N di(propan-2-yl)azanide Chemical compound CC(C)[N-]C(C)C PBGGNZZGJIKBMJ-UHFFFAOYSA-N 0.000 claims description 2
LQJVHIOSGBLNRR-UHFFFAOYSA-N ethyl 1-(3-cyclopentylpropanoyl)piperidine-3-carboxylate Chemical compound C1C(C(=O)OCC)CCCN1C(=O)CCC1CCCC1 LQJVHIOSGBLNRR-UHFFFAOYSA-N 0.000 claims description 2
ZINWADPKZHBBEQ-UHFFFAOYSA-N ethyl 1-[5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]piperidine-4-carboxylate Chemical compound C1CC(C(=O)OCC)CCN1C(=O)C1=C2N=C(C=3C=C(OC)C=CC=3)C=C(C(F)(F)F)N2N=C1 ZINWADPKZHBBEQ-UHFFFAOYSA-N 0.000 claims description 2
LXMMPYWOJVDLMJ-UHFFFAOYSA-N ethyl 1-benzoylpiperidine-2-carboxylate Chemical compound CCOC(=O)C1CCCCN1C(=O)C1=CC=CC=C1 LXMMPYWOJVDLMJ-UHFFFAOYSA-N 0.000 claims description 2
DZTAJGBADYJNRE-UHFFFAOYSA-N ethyl 2-(adamantane-1-carbonylamino)benzoate Chemical compound CCOC(=O)C1=CC=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 DZTAJGBADYJNRE-UHFFFAOYSA-N 0.000 claims description 2
DXAPIMIWEMKPPC-UHFFFAOYSA-N ethyl 2-[benzyl-(4-nitrobenzoyl)amino]acetate Chemical compound C=1C=C([N+]([O-])=O)C=CC=1C(=O)N(CC(=O)OCC)CC1=CC=CC=C1 DXAPIMIWEMKPPC-UHFFFAOYSA-N 0.000 claims description 2
WXWBQJRIFVEWGT-UHFFFAOYSA-N ethyl 2-amino-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate Chemical compound CCOC(=O)C1=C(N)SC(C(=O)N2CCCCC2)=C1C WXWBQJRIFVEWGT-UHFFFAOYSA-N 0.000 claims description 2
ONEQTHCBJHMZHZ-UHFFFAOYSA-N ethyl 2-amino-5-(cyclohexylcarbamoyl)-4-methylthiophene-3-carboxylate Chemical compound CCOC(=O)C1=C(N)SC(C(=O)NC2CCCCC2)=C1C ONEQTHCBJHMZHZ-UHFFFAOYSA-N 0.000 claims description 2
RLBFFEWLRWWGIW-UHFFFAOYSA-N ethyl 4-(5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonyl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)C1=C2N=C(C)C=C(C)N2N=C1 RLBFFEWLRWWGIW-UHFFFAOYSA-N 0.000 claims description 2
AEFHHMQJRBXPQR-UHFFFAOYSA-N ethyl 4-[5-(1,3-benzodioxol-5-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)C1=NN2C(C(F)(F)F)=CC(C=3C=C4OCOC4=CC=3)=NC2=C1 AEFHHMQJRBXPQR-UHFFFAOYSA-N 0.000 claims description 2
BPYGZANGQJXJBZ-UHFFFAOYSA-N ethyl 4-[5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)C1=C2N=C(C=3C=C(OC)C=CC=3)C=C(C(F)(F)F)N2N=C1 BPYGZANGQJXJBZ-UHFFFAOYSA-N 0.000 claims description 2
APSWRCMFDKPCOL-UHFFFAOYSA-N ethyl 4-[[3-methoxy-5-(pyridine-2-carbonyl)benzoyl]amino]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1NC(=O)C1=CC(OC)=CC(C(=O)C=2N=CC=CC=2)=C1 APSWRCMFDKPCOL-UHFFFAOYSA-N 0.000 claims description 2
KBIJOMUAIJBJRE-UHFFFAOYSA-N furan-2-yl-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]methanone Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1CCN(C(=O)C=2OC=CC=2)CC1 KBIJOMUAIJBJRE-UHFFFAOYSA-N 0.000 claims description 2
BQAMRQIYPDLYCD-UHFFFAOYSA-N methyl 1-[7-(difluoromethyl)-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]indole-3-carboxylate Chemical compound C12=CC=CC=C2C(C(=O)OC)=CN1C(=O)C(=C1N=2)C=NN1C(C(F)F)=CC=2C1=CC=C(OC)C=C1 BQAMRQIYPDLYCD-UHFFFAOYSA-N 0.000 claims description 2
ZJZIVDCVOLKKFB-UHFFFAOYSA-N methyl 2-(adamantane-1-carbonylamino)-3-phenylpropanoate Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC(C(=O)OC)CC1=CC=CC=C1 ZJZIVDCVOLKKFB-UHFFFAOYSA-N 0.000 claims description 2
HJWKNMQFBNEIPC-UHFFFAOYSA-N methyl 2-[(2-methoxybenzoyl)amino]-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate Chemical compound COC(=O)C=1C(C)=C(C(=O)N2CCCCC2)SC=1NC(=O)C1=CC=CC=C1OC HJWKNMQFBNEIPC-UHFFFAOYSA-N 0.000 claims description 2
FBSJQHFZRYKPQK-UHFFFAOYSA-N methyl 2-[(3-fluorobenzoyl)amino]-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate Chemical compound COC(=O)C=1C(C)=C(C(=O)N2CCCCC2)SC=1NC(=O)C1=CC=CC(F)=C1 FBSJQHFZRYKPQK-UHFFFAOYSA-N 0.000 claims description 2
LLGCIOWMDCLFGV-UHFFFAOYSA-N methyl 2-[[3-(4-methylphenyl)adamantane-1-carbonyl]amino]propanoate Chemical compound C1C(C(=O)NC(C)C(=O)OC)(C2)CC(C3)CC1CC32C1=CC=C(C)C=C1 LLGCIOWMDCLFGV-UHFFFAOYSA-N 0.000 claims description 2
QPCZVFDRLFBYKQ-UHFFFAOYSA-N methyl 7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carboxylate Chemical compound C1=C(C)N2N=C(C(=O)OC)C=C2N=C1C1=CC=CC=C1 QPCZVFDRLFBYKQ-UHFFFAOYSA-N 0.000 claims description 2
GPGKYRAMDAROJU-UHFFFAOYSA-N morpholin-4-yl-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1=NC2=CC(C(=O)N3CCOCC3)=NN2C(C(F)(F)F)=C1 GPGKYRAMDAROJU-UHFFFAOYSA-N 0.000 claims description 2
VMIRXFZOESFYDS-UHFFFAOYSA-N morpholin-4-yl-[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound C1=NN2C(C(F)(F)F)=CC(C=3C=CC=CC=3)=NC2=C1C(=O)N1CCOCC1 VMIRXFZOESFYDS-UHFFFAOYSA-N 0.000 claims description 2
JFJFMNYEFJABEO-UHFFFAOYSA-N morpholin-4-yl-[5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone Chemical compound N=1N2C(C(F)(F)F)=CC(C=3SC=CC=3)=NC2=CC=1C(=O)N1CCOCC1 JFJFMNYEFJABEO-UHFFFAOYSA-N 0.000 claims description 2
UANPVYJHWJUJGP-UHFFFAOYSA-N morpholin-4-yl-[7-(trifluoromethyl)-5-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone Chemical compound COC1=C(OC)C(OC)=CC(C2=NC3=C(C(=O)N4CCOCC4)C=NN3C(=C2)C(F)(F)F)=C1 UANPVYJHWJUJGP-UHFFFAOYSA-N 0.000 claims description 2
ISINGHVAECMBPX-UHFFFAOYSA-N n'-(3,7,7-trimethyl-4-bicyclo[2.2.1]heptanyl)-n-(4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl)hexanediamide Chemical compound C1C(C2(C)C)CCC2(C)C1NC(=O)CCCCC(=O)NC1(C2(C)C)CCC2CC1C ISINGHVAECMBPX-UHFFFAOYSA-N 0.000 claims description 2
CBICPLYVLNSDTG-UHFFFAOYSA-N n'-(4-methylphenyl)-n-[4-(1-naphthalen-2-ylsulfonylpiperidin-3-yl)butyl]oxamide Chemical compound C1=CC(C)=CC=C1NC(=O)C(=O)NCCCCC1CN(S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CCC1 CBICPLYVLNSDTG-UHFFFAOYSA-N 0.000 claims description 2
XQUPIYUNYHIPPF-UHFFFAOYSA-N n,n'-bis(2,4-difluorophenyl)-3,3-dimethylpentanediamide Chemical compound C=1C=C(F)C=C(F)C=1NC(=O)CC(C)(C)CC(=O)NC1=CC=C(F)C=C1F XQUPIYUNYHIPPF-UHFFFAOYSA-N 0.000 claims description 2
FBVXYPJHMXIEIE-UHFFFAOYSA-N n,n-dibenzyl-2-fluorobenzamide Chemical compound FC1=CC=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 FBVXYPJHMXIEIE-UHFFFAOYSA-N 0.000 claims description 2
LGXXIXHEOKUPTC-UHFFFAOYSA-N n,n-dibenzyl-3,4-dimethoxybenzamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 LGXXIXHEOKUPTC-UHFFFAOYSA-N 0.000 claims description 2
BSVBUMJNVPLWLP-UHFFFAOYSA-N n,n-dibenzyl-3-chloro-1-benzothiophene-2-carboxamide Chemical compound S1C2=CC=CC=C2C(Cl)=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 BSVBUMJNVPLWLP-UHFFFAOYSA-N 0.000 claims description 2
UGHSNYACOXBNJJ-UHFFFAOYSA-N n,n-dibenzyl-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 UGHSNYACOXBNJJ-UHFFFAOYSA-N 0.000 claims description 2
ASTXNWPSIPDNBE-UHFFFAOYSA-N n,n-dibenzylthiophene-2-carboxamide Chemical compound C=1C=CSC=1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 ASTXNWPSIPDNBE-UHFFFAOYSA-N 0.000 claims description 2
UDVDKLWQHCSBQO-UHFFFAOYSA-N n,n-diethyl-1-(2-nitrophenyl)piperidine-3-carboxamide Chemical compound C1C(C(=O)N(CC)CC)CCCN1C1=CC=CC=C1[N+]([O-])=O UDVDKLWQHCSBQO-UHFFFAOYSA-N 0.000 claims description 2
SAPCUOAGJIIDAQ-UHFFFAOYSA-N n,n-diethyl-1-(4-nitrophenyl)piperidine-3-carboxamide Chemical compound C1C(C(=O)N(CC)CC)CCCN1C1=CC=C([N+]([O-])=O)C=C1 SAPCUOAGJIIDAQ-UHFFFAOYSA-N 0.000 claims description 2
QKSOXXNRTPOXPG-UHFFFAOYSA-N n,n-dimethyl-2-[3-(4-nitrophenyl)-1-adamantyl]acetamide Chemical compound C1C(CC(=O)N(C)C)(C2)CC(C3)CC1CC32C1=CC=C([N+]([O-])=O)C=C1 QKSOXXNRTPOXPG-UHFFFAOYSA-N 0.000 claims description 2
RMRZPLJAVNSFCJ-UHFFFAOYSA-N n,n-dimethyladamantane-1-carboxamide Chemical compound C1C(C2)CC3CC2CC1(C(=O)N(C)C)C3 RMRZPLJAVNSFCJ-UHFFFAOYSA-N 0.000 claims description 2
NHNAYPQCUJLMGT-UHFFFAOYSA-N n-(1,1-dioxothiolan-3-yl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC1CCS(=O)(=O)C1 NHNAYPQCUJLMGT-UHFFFAOYSA-N 0.000 claims description 2
KILTUXSBXYMWIF-UHFFFAOYSA-N n-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-benzothiophene-3-carboxamide Chemical compound C1=CC=C2C(C(NC3C4=CC=CC=C4CCC3)=O)=CSC2=C1 KILTUXSBXYMWIF-UHFFFAOYSA-N 0.000 claims description 2
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HUXDABLEJAOGSF-UHFFFAOYSA-N n-(1,3-benzodioxol-5-yl)-2,4-dichlorobenzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)NC1=CC=C(OCO2)C2=C1 HUXDABLEJAOGSF-UHFFFAOYSA-N 0.000 claims description 2
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UHFLHKZQPYROIV-UHFFFAOYSA-N n-(1-adamantyl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)CSC1=NN=NN1C1=CC=CC=C1 UHFLHKZQPYROIV-UHFFFAOYSA-N 0.000 claims description 2
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GOENUIKRCHXARD-UHFFFAOYSA-N n-(1-adamantyl)-2-(4-chloro-3,5-dimethylphenoxy)acetamide Chemical compound CC1=C(Cl)C(C)=CC(OCC(=O)NC23CC4CC(CC(C4)C2)C3)=C1 GOENUIKRCHXARD-UHFFFAOYSA-N 0.000 claims description 2
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FXHPOENPCCODRV-UHFFFAOYSA-N n-(1-adamantyl)-2-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC=C1C(=O)NC1(C2)CC(C3)CC2CC3C1 FXHPOENPCCODRV-UHFFFAOYSA-N 0.000 claims description 2
PLYMLEDYLXUWQE-UHFFFAOYSA-N n-(1-adamantyl)-2-[3-cyano-4-(methoxymethyl)-6-methylpyridin-2-yl]sulfanylacetamide Chemical compound COCC1=CC(C)=NC(SCC(=O)NC23CC4CC(CC(C4)C2)C3)=C1C#N PLYMLEDYLXUWQE-UHFFFAOYSA-N 0.000 claims description 2
CWVWQVATULDMEQ-UHFFFAOYSA-N n-(1-adamantyl)-2-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide Chemical compound CC1=CC(C(F)(F)F)=C(C#N)C(SCC(=O)NC23CC4CC(CC(C4)C2)C3)=N1 CWVWQVATULDMEQ-UHFFFAOYSA-N 0.000 claims description 2
CJODTCFLRSBSLN-UHFFFAOYSA-N n-(1-adamantyl)-2-benzoylbenzamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 CJODTCFLRSBSLN-UHFFFAOYSA-N 0.000 claims description 2
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DWDQKLYPTWAANY-UHFFFAOYSA-N n-(1-adamantyl)-2-hydroxy-2,2-diphenylacetamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)C(O)(C=1C=CC=CC=1)C1=CC=CC=C1 DWDQKLYPTWAANY-UHFFFAOYSA-N 0.000 claims description 2
HUPCYIXCIGDBEI-UHFFFAOYSA-N n-(1-adamantyl)-2-naphthalen-2-yloxyacetamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)COC1=CC=C(C=CC=C2)C2=C1 HUPCYIXCIGDBEI-UHFFFAOYSA-N 0.000 claims description 2
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YUNYVNQCZMXLBU-UHFFFAOYSA-N n-(1-adamantyl)-3-morpholin-4-ylpropanamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)CCN1CCOCC1 YUNYVNQCZMXLBU-UHFFFAOYSA-N 0.000 claims description 2
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DUJRYRIBSSDRAH-UHFFFAOYSA-N n-(1-naphthalen-2-ylsulfonylpyrrolidin-2-yl)cyclooctanecarboxamide Chemical compound C1CCN(S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)C1NC(=O)C1CCCCCCC1 DUJRYRIBSSDRAH-UHFFFAOYSA-N 0.000 claims description 2
FFEQAHZYGJLBIM-UHFFFAOYSA-N n-(2,3-dihydroxypropyl)-2-(2-phenyl-2-adamantyl)acetamide Chemical compound C1C2CC(C3)CC1CC3C2(CC(=O)NCC(O)CO)C1=CC=CC=C1 FFEQAHZYGJLBIM-UHFFFAOYSA-N 0.000 claims description 2
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JBIYUSDGIZZPFK-UHFFFAOYSA-N n-(2,3-dimethylphenyl)-4-[methyl-(4-methylphenyl)sulfonylamino]butanamide Chemical compound C=1C=C(C)C=CC=1S(=O)(=O)N(C)CCCC(=O)NC1=CC=CC(C)=C1C JBIYUSDGIZZPFK-UHFFFAOYSA-N 0.000 claims description 2
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ZMRKCHNOLVTZSZ-UHFFFAOYSA-N n-(2,4-dioxo-1h-pyrimidin-6-yl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC1=CC(=O)NC(=O)N1 ZMRKCHNOLVTZSZ-UHFFFAOYSA-N 0.000 claims description 2
RKHGNDOZLYTNCV-UHFFFAOYSA-N n-(2,5-dichlorophenyl)-3-(4-methylphenyl)adamantane-1-carboxamide Chemical compound C1=CC(C)=CC=C1C1(C2)CC(C3)(C(=O)NC=4C(=CC=C(Cl)C=4)Cl)CC2CC3C1 RKHGNDOZLYTNCV-UHFFFAOYSA-N 0.000 claims description 2
NNVQBXAWWYCGPB-UHFFFAOYSA-N n-(2,6-dimethoxypyrimidin-4-yl)adamantane-1-carboxamide Chemical compound COC1=NC(OC)=CC(NC(=O)C23CC4CC(CC(C4)C2)C3)=N1 NNVQBXAWWYCGPB-UHFFFAOYSA-N 0.000 claims description 2
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QZWBRACYOPBUKD-UHFFFAOYSA-N n-(2-adamantyl)-5-[(4-bromo-3,5-dimethylpyrazol-1-yl)methyl]furan-2-carboxamide Chemical compound CC1=C(Br)C(C)=NN1CC1=CC=C(C(=O)NC2C3CC4CC(C3)CC2C4)O1 QZWBRACYOPBUKD-UHFFFAOYSA-N 0.000 claims description 2
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QIVDJLKQZIKMHS-UHFFFAOYSA-N n-(2-ethoxyphenyl)adamantane-1-carboxamide Chemical compound CCOC1=CC=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 QIVDJLKQZIKMHS-UHFFFAOYSA-N 0.000 claims description 2
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RBWBVWSBZRZYFT-UHFFFAOYSA-N n-(2-phenylsulfanylphenyl)cyclohexanecarboxamide Chemical compound C1CCCCC1C(=O)NC1=CC=CC=C1SC1=CC=CC=C1 RBWBVWSBZRZYFT-UHFFFAOYSA-N 0.000 claims description 2
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HQTYULSTMYRLOD-UHFFFAOYSA-N n-(3,3,5-trimethylcyclohexyl)-1-benzothiophene-3-carboxamide Chemical compound C1C(C)(C)CC(C)CC1NC(=O)C1=CSC2=CC=CC=C12 HQTYULSTMYRLOD-UHFFFAOYSA-N 0.000 claims description 2
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HQCLGXUJYCTEKD-UHFFFAOYSA-N n-(3,4-dihydro-1h-isochromen-1-ylmethyl)-3-(4-hydroxyphenyl)-3-phenylpropanamide Chemical compound C1=CC(O)=CC=C1C(C=1C=CC=CC=1)CC(=O)NCC1C2=CC=CC=C2CCO1 HQCLGXUJYCTEKD-UHFFFAOYSA-N 0.000 claims description 2
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RORYGMMLGCGOON-UHFFFAOYSA-N n-(3-amino-2,2-dimethylpropyl)-4-[2-(2-propan-2-ylphenyl)sulfanylethyl]benzamide Chemical compound CC(C)C1=CC=CC=C1SCCC1=CC=C(C(=O)NCC(C)(C)CN)C=C1 RORYGMMLGCGOON-UHFFFAOYSA-N 0.000 claims description 2
GTHDKSMWRJXYEF-UHFFFAOYSA-N n-(3-amino-2,2-dimethylpropyl)-4-[[4-(4-chlorophenyl)pyrimidin-2-yl]sulfanylmethyl]-3-nitrobenzamide Chemical compound [O-][N+](=O)C1=CC(C(=O)NCC(C)(CN)C)=CC=C1CSC1=NC=CC(C=2C=CC(Cl)=CC=2)=N1 GTHDKSMWRJXYEF-UHFFFAOYSA-N 0.000 claims description 2
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MZHYRSJOERZVSR-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide Chemical compound C1OC2=CC=CC=C2OC1C(=O)NC1C(C2)CCC2C1 MZHYRSJOERZVSR-UHFFFAOYSA-N 0.000 claims description 2
SVRBVAGZOMOUJS-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-2-[(2-chlorophenyl)methylsulfanyl]acetamide Chemical compound ClC1=CC=CC=C1CSCC(=O)NC1C(C2)CCC2C1 SVRBVAGZOMOUJS-UHFFFAOYSA-N 0.000 claims description 2
VLNNNESZIBWEHH-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-2-chlorobenzamide Chemical compound ClC1=CC=CC=C1C(=O)NC1C(C2)CCC2C1 VLNNNESZIBWEHH-UHFFFAOYSA-N 0.000 claims description 2
OIPPNLNOXRYSAK-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-3-cyclopentylpropanamide Chemical compound C1C(C2)CCC2C1NC(=O)CCC1CCCC1 OIPPNLNOXRYSAK-UHFFFAOYSA-N 0.000 claims description 2
KBGVBELNPALBJS-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-3-phenylsulfanylpropanamide Chemical compound C1C(C2)CCC2C1NC(=O)CCSC1=CC=CC=C1 KBGVBELNPALBJS-UHFFFAOYSA-N 0.000 claims description 2
FFZYPUYWTIIDEL-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-4-(morpholin-4-ylmethyl)benzamide Chemical compound C1C(C2)CCC2C1NC(=O)C(C=C1)=CC=C1CN1CCOCC1 FFZYPUYWTIIDEL-UHFFFAOYSA-N 0.000 claims description 2
LJWYXYYTYFGGNP-UHFFFAOYSA-N n-(3-chloro-4-hydroxyphenyl)-2-(cyclohexylamino)-1,3-thiazole-4-carboxamide Chemical compound C1=C(Cl)C(O)=CC=C1NC(=O)C1=CSC(NC2CCCCC2)=N1 LJWYXYYTYFGGNP-UHFFFAOYSA-N 0.000 claims description 2
QDQDCZORMCIXHY-UHFFFAOYSA-N n-(3-chlorophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide Chemical compound ClC1=CC=CC(NC(=O)C2CC(=O)N(C3CCCCC3)C2)=C1 QDQDCZORMCIXHY-UHFFFAOYSA-N 0.000 claims description 2
GTIYDDYACYJWJM-UHFFFAOYSA-N n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide Chemical compound S1C=2CCCCC=2C(C#N)=C1NC(=O)C(CC1=O)CN1C1CCCCC1 GTIYDDYACYJWJM-UHFFFAOYSA-N 0.000 claims description 2
PFNLHNUAHGURMS-UHFFFAOYSA-N n-(3-ethoxypropyl)-n-[(4-hydroxyphenyl)methyl]heptanamide Chemical compound CCCCCCC(=O)N(CCCOCC)CC1=CC=C(O)C=C1 PFNLHNUAHGURMS-UHFFFAOYSA-N 0.000 claims description 2
NDBGMPBQTHIHGD-UHFFFAOYSA-N n-(3-hexylsulfanyl-1,2,4-thiadiazol-5-yl)-3-methylbutanamide Chemical compound CCCCCCSC1=NSC(NC(=O)CC(C)C)=N1 NDBGMPBQTHIHGD-UHFFFAOYSA-N 0.000 claims description 2
CRUANUTZEHQTOZ-UHFFFAOYSA-N n-(3-methylbutyl)-9-oxofluorene-1-carboxamide Chemical compound C12=CC=CC=C2C(=O)C2=C1C=CC=C2C(=O)NCCC(C)C CRUANUTZEHQTOZ-UHFFFAOYSA-N 0.000 claims description 2
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VBZTZJLJCNOGMW-UHFFFAOYSA-N n-(4-acetylphenyl)-2-(2-phenyl-2-adamantyl)acetamide Chemical compound C1=CC(C(=O)C)=CC=C1NC(=O)CC1(C=2C=CC=CC=2)C(C2)CC3CC2CC1C3 VBZTZJLJCNOGMW-UHFFFAOYSA-N 0.000 claims description 2
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VJEFEBDPMPLANV-UHFFFAOYSA-N n-(4-chloro-3-nitrophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide Chemical compound C1=C(Cl)C([N+](=O)[O-])=CC(NC(=O)C2CC(=O)N(C3CCCCC3)C2)=C1 VJEFEBDPMPLANV-UHFFFAOYSA-N 0.000 claims description 2
UWZJMCNFDLBYDY-UHFFFAOYSA-N n-(4-tert-butyl-3-nitrophenyl)acetamide Chemical compound CC(=O)NC1=CC=C(C(C)(C)C)C([N+]([O-])=O)=C1 UWZJMCNFDLBYDY-UHFFFAOYSA-N 0.000 claims description 2
JDKWQEOMIREADG-UHFFFAOYSA-N n-(5-benzoyl-4-phenyl-1,3-thiazol-2-yl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC(S1)=NC(C=2C=CC=CC=2)=C1C(=O)C1=CC=CC=C1 JDKWQEOMIREADG-UHFFFAOYSA-N 0.000 claims description 2
AEKKMIRZNOZHOS-UHFFFAOYSA-N n-(5-bicyclo[2.2.1]hept-2-enylmethyl)-2,4-dichloro-n-[2-(1h-indol-3-yl)ethyl]benzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)N(CC1C2CC(C=C2)C1)CCC1=CNC2=CC=CC=C12 AEKKMIRZNOZHOS-UHFFFAOYSA-N 0.000 claims description 2
JNFUJUPCFPJNOJ-UHFFFAOYSA-N n-(5-bicyclo[2.2.1]hept-2-enylmethyl)-3-cyclopentyl-n-[2-(1h-indol-3-yl)ethyl]propanamide Chemical compound C=1NC2=CC=CC=C2C=1CCN(CC1C2CC(C=C2)C1)C(=O)CCC1CCCC1 JNFUJUPCFPJNOJ-UHFFFAOYSA-N 0.000 claims description 2
DLGNYUUYPGAJCI-UHFFFAOYSA-N n-(5-hexyl-1,3,4-thiadiazol-2-yl)-2-methylpropanamide Chemical compound CCCCCCC1=NN=C(NC(=O)C(C)C)S1 DLGNYUUYPGAJCI-UHFFFAOYSA-N 0.000 claims description 2
QBWPAMLNPUEMQM-UHFFFAOYSA-N n-(5-methylpyridin-2-yl)adamantane-1-carboxamide Chemical compound N1=CC(C)=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 QBWPAMLNPUEMQM-UHFFFAOYSA-N 0.000 claims description 2
MBDYWOZBEJJCRE-UHFFFAOYSA-N n-(7,7-dimethyl-5-oxo-6,8-dihydroquinazolin-2-yl)cyclohexanecarboxamide Chemical compound N1=C2CC(C)(C)CC(=O)C2=CN=C1NC(=O)C1CCCCC1 MBDYWOZBEJJCRE-UHFFFAOYSA-N 0.000 claims description 2
PSPZLHVPXKCSTO-UHFFFAOYSA-N n-(furan-2-ylmethyl)-2-phenyl-2-phenylsulfanylacetamide Chemical compound C=1C=CC=CC=1SC(C=1C=CC=CC=1)C(=O)NCC1=CC=CO1 PSPZLHVPXKCSTO-UHFFFAOYSA-N 0.000 claims description 2
NHRXPFXVQMNCOV-UHFFFAOYSA-N n-(furan-2-ylmethyl)-n-(4-methylphenyl)adamantane-1-carboxamide Chemical compound C1=CC(C)=CC=C1N(C(=O)C12CC3CC(CC(C3)C1)C2)CC1=CC=CO1 NHRXPFXVQMNCOV-UHFFFAOYSA-N 0.000 claims description 2
WURJNPARHWUNFY-UHFFFAOYSA-N n-(naphthalen-1-ylmethyl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NCC1=CC=CC2=CC=CC=C12 WURJNPARHWUNFY-UHFFFAOYSA-N 0.000 claims description 2
DTMIDUIIAAJUOO-UHFFFAOYSA-N n-(oxolan-2-ylmethyl)-2-(2-phenylethyl)benzamide Chemical compound C=1C=CC=C(CCC=2C=CC=CC=2)C=1C(=O)NCC1CCCO1 DTMIDUIIAAJUOO-UHFFFAOYSA-N 0.000 claims description 2
ZTLHMUKWSKSSEP-UHFFFAOYSA-N n-(oxolan-2-ylmethyl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NCC1CCCO1 ZTLHMUKWSKSSEP-UHFFFAOYSA-N 0.000 claims description 2
NLFJLMOIXJFXNH-UHFFFAOYSA-N n-[(1,3-dimethylpyrazol-4-yl)methyl]-n-methyl-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=C2N=C(C=3C=CC=CC=3)C=C(C(F)(F)F)N2N=C1C(=O)N(C)CC1=CN(C)N=C1C NLFJLMOIXJFXNH-UHFFFAOYSA-N 0.000 claims description 2
OPQKNGDNBBMEDA-UHFFFAOYSA-N n-[(1,3-dioxoisoindol-2-yl)methyl]-n-(4-fluorophenyl)benzamide Chemical compound C1=CC(F)=CC=C1N(C(=O)C=1C=CC=CC=1)CN1C(=O)C2=CC=CC=C2C1=O OPQKNGDNBBMEDA-UHFFFAOYSA-N 0.000 claims description 2
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PJWUAFNNTFUQEE-UHFFFAOYSA-N n-[(1,5-dimethylpyrazol-4-yl)methyl]-n-methyl-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical compound C1=C2N=C(C=3SC=CC=3)C=C(C(F)(F)F)N2N=C1C(=O)N(C)CC=1C=NN(C)C=1C PJWUAFNNTFUQEE-UHFFFAOYSA-N 0.000 claims description 2
GINFDOGZDWKVLS-UHFFFAOYSA-N n-[(1-methyl-2,3-dihydroindol-5-yl)methyl]-n-(oxolan-2-ylmethyl)benzamide Chemical compound C=1C=C2N(C)CCC2=CC=1CN(C(=O)C=1C=CC=CC=1)CC1CCCO1 GINFDOGZDWKVLS-UHFFFAOYSA-N 0.000 claims description 2
GHRBREPMRJCPLY-UHFFFAOYSA-N n-[(1-phenylcyclopentyl)methyl]-2-piperidin-1-ylpropanamide Chemical compound C1CCCC1(C=1C=CC=CC=1)CNC(=O)C(C)N1CCCCC1 GHRBREPMRJCPLY-UHFFFAOYSA-N 0.000 claims description 2
VAVLKSDOICPCHK-UHFFFAOYSA-N n-[(2-chlorophenyl)methyl]-n-[(4-hydroxyphenyl)methyl]-2-thiophen-2-ylacetamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CC=1SC=CC=1)CC1=CC=CC=C1Cl VAVLKSDOICPCHK-UHFFFAOYSA-N 0.000 claims description 2
FNGVCJCDXMEMAT-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-3-thiophen-3-yl-n-(2-thiophen-2-ylethyl)prop-2-enamide Chemical compound OC1=CC=CC=C1CN(C(=O)C=CC1=CSC=C1)CCC1=CC=CS1 FNGVCJCDXMEMAT-UHFFFAOYSA-N 0.000 claims description 2
GSLNTOBTTFVTSR-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-n-(2-methylpropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CC(C)C)CC1=CC=CC=C1O GSLNTOBTTFVTSR-UHFFFAOYSA-N 0.000 claims description 2
USSKZFGBHIMMME-UHFFFAOYSA-N n-[(3,4-dimethoxyphenyl)methyl]-3-methoxy-n-[6-(pyridin-2-ylamino)hexyl]benzamide Chemical compound COC1=CC=CC(C(=O)N(CCCCCCNC=2N=CC=CC=2)CC=2C=C(OC)C(OC)=CC=2)=C1 USSKZFGBHIMMME-UHFFFAOYSA-N 0.000 claims description 2
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NRPVGZUSINBTMC-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-[(4-propan-2-ylphenyl)methyl]heptanamide Chemical compound C=1C=CC(O)=CC=1CN(C(=O)CCCCCC)CC1=CC=C(C(C)C)C=C1 NRPVGZUSINBTMC-UHFFFAOYSA-N 0.000 claims description 2
YSZOMHNVGDQPMU-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-[2-(2-methoxyphenyl)ethyl]-2-methylpent-4-enamide Chemical compound COC1=CC=CC=C1CCN(C(=O)C(C)CC=C)CC1=CC=CC(O)=C1 YSZOMHNVGDQPMU-UHFFFAOYSA-N 0.000 claims description 2
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NBENJNKWKCXLAB-UHFFFAOYSA-N n-[(4-fluorophenyl)methyl]-n-[(4-hydroxyphenyl)methyl]-2-thiophen-3-ylacetamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CC1=CSC=C1)CC1=CC=C(F)C=C1 NBENJNKWKCXLAB-UHFFFAOYSA-N 0.000 claims description 2
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ASBHVXQJQYSXHO-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-[[4-(trifluoromethyl)phenyl]methyl]dec-3-enamide Chemical compound C=1C=C(C(F)(F)F)C=CC=1CN(C(=O)CC=CCCCCCC)CC1=CC=C(O)C=C1 ASBHVXQJQYSXHO-UHFFFAOYSA-N 0.000 claims description 2
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CDHCEBSOSLZVMO-UHFFFAOYSA-N n-[(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)methyl]-5-[(3-methylsulfanyl-1,2,4-thiadiazol-5-yl)sulfanyl]pentanamide Chemical compound CSC1=NSC(SCCCCC(=O)NCC2C3CC(C3(C)C)CC2)=N1 CDHCEBSOSLZVMO-UHFFFAOYSA-N 0.000 claims description 2
IBVKTCPCJMRCSA-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C1=CC=C(OCCO2)C2=C1 IBVKTCPCJMRCSA-UHFFFAOYSA-N 0.000 claims description 2
YKIPYXONFJLDLW-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-2,5-dimethylfuran-3-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C=1C=C(C)OC=1C YKIPYXONFJLDLW-UHFFFAOYSA-N 0.000 claims description 2
AMEAJMHDBTWKNQ-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-2-fluorobenzamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C1=CC=CC=C1F AMEAJMHDBTWKNQ-UHFFFAOYSA-N 0.000 claims description 2
VRSWNXIEMWQXOU-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-5-methylfuran-2-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C1=CC=C(C)O1 VRSWNXIEMWQXOU-UHFFFAOYSA-N 0.000 claims description 2
YHYIXRWFLNNBGZ-UHFFFAOYSA-N n-[1-(1h-indol-3-yl)propan-2-yl]-2-[4-(2-methylpropyl)phenyl]propanamide Chemical compound C1=CC(CC(C)C)=CC=C1C(C)C(=O)NC(C)CC1=CNC2=CC=CC=C12 YHYIXRWFLNNBGZ-UHFFFAOYSA-N 0.000 claims description 2
TZCBDOWPXZABRM-UHFFFAOYSA-N n-[1-(3-bicyclo[2.2.1]heptanyl)ethyl]-5-[(2-chlorophenoxy)methyl]furan-2-carboxamide Chemical compound C1C(C2)CCC2C1C(C)NC(=O)C(O1)=CC=C1COC1=CC=CC=C1Cl TZCBDOWPXZABRM-UHFFFAOYSA-N 0.000 claims description 2
LBXXOCMWSQMMAT-UHFFFAOYSA-N n-[1-(4-methylsulfonylphenyl)ethyl]-n-(oxolan-2-ylmethyl)benzamide Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C)N(C(=O)C=1C=CC=CC=1)CC1CCCO1 LBXXOCMWSQMMAT-UHFFFAOYSA-N 0.000 claims description 2
AVQSJOYFYMHMRG-UHFFFAOYSA-N n-[2-(2,4-dichlorophenyl)ethyl]-n-[(4-hydroxyphenyl)methyl]-2-thiophen-3-ylacetamide Chemical compound C1=CC(O)=CC=C1CN(C(=O)CC1=CSC=C1)CCC1=CC=C(Cl)C=C1Cl AVQSJOYFYMHMRG-UHFFFAOYSA-N 0.000 claims description 2
CNXPJWQHCFGZAE-UHFFFAOYSA-N n-[2-(2,4-dimethoxyphenyl)ethyl]adamantane-1-carboxamide Chemical compound COC1=CC(OC)=CC=C1CCNC(=O)C1(C2)CC(C3)CC2CC3C1 CNXPJWQHCFGZAE-UHFFFAOYSA-N 0.000 claims description 2
VLBKSUVJJWLCAW-UHFFFAOYSA-N n-[2-(2-bromophenyl)-1,3-benzoxazol-5-yl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)NC1=CC=C(OC(=N2)C=3C(=CC=CC=3)Br)C2=C1 VLBKSUVJJWLCAW-UHFFFAOYSA-N 0.000 claims description 2
QKZYFEVSPOZFPU-UHFFFAOYSA-N n-[2-(3,4-dimethoxyphenyl)ethyl]adamantane-1-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1CCNC(=O)C1(C2)CC(C3)CC2CC3C1 QKZYFEVSPOZFPU-UHFFFAOYSA-N 0.000 claims description 2
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BQJHVYYYKRPGIM-UHFFFAOYSA-N n-[2-(4-piperidin-1-ylsulfonylphenyl)ethyl]acetamide Chemical compound C1=CC(CCNC(=O)C)=CC=C1S(=O)(=O)N1CCCCC1 BQJHVYYYKRPGIM-UHFFFAOYSA-N 0.000 claims description 2
WRSAPVFSDCSPOJ-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-(4-ethoxyphenyl)-4-methylsulfanylbenzenesulfonamide Chemical compound C1=CC(OCC)=CC=C1N(S(=O)(=O)C=1C=CC(SC)=CC=1)CC(=O)N1CCCCCC1 WRSAPVFSDCSPOJ-UHFFFAOYSA-N 0.000 claims description 2
HITRICNKSDFOBE-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-(4-propan-2-ylphenyl)methanesulfonamide Chemical compound C1=CC(C(C)C)=CC=C1N(S(C)(=O)=O)CC(=O)N1CCCCCC1 HITRICNKSDFOBE-UHFFFAOYSA-N 0.000 claims description 2
CLBSULJBGZYOFD-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-benzyl-4-bromobenzenesulfonamide Chemical compound C1=CC(Br)=CC=C1S(=O)(=O)N(CC=1C=CC=CC=1)CC(=O)N1CCCCCC1 CLBSULJBGZYOFD-UHFFFAOYSA-N 0.000 claims description 2
GFOODFAWMIVFLW-UHFFFAOYSA-N n-[2-(azepan-1-yl)-2-oxoethyl]-n-benzyl-4-fluorobenzenesulfonamide Chemical compound C1=CC(F)=CC=C1S(=O)(=O)N(CC=1C=CC=CC=1)CC(=O)N1CCCCCC1 GFOODFAWMIVFLW-UHFFFAOYSA-N 0.000 claims description 2
GFCZFUKLFGZZKP-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-2-(1,3-dioxoisoindol-2-yl)propanamide Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C)C(=O)NCCC1=CCCCC1 GFCZFUKLFGZZKP-UHFFFAOYSA-N 0.000 claims description 2
YSLGNUBOLKYCJY-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-2-(2-methylphenoxy)acetamide Chemical compound CC1=CC=CC=C1OCC(=O)NCCC1=CCCCC1 YSLGNUBOLKYCJY-UHFFFAOYSA-N 0.000 claims description 2
GMNVFEWSZLMHGA-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-3-methoxybenzamide Chemical compound COC1=CC=CC(C(=O)NCCC=2CCCCC=2)=C1 GMNVFEWSZLMHGA-UHFFFAOYSA-N 0.000 claims description 2
WWZYAMAABWPOGT-UHFFFAOYSA-N n-[2-(cyclohexen-1-yl)ethyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C=1SC=2CCCCC=2C=1C(=O)NCCC1=CCCCC1 WWZYAMAABWPOGT-UHFFFAOYSA-N 0.000 claims description 2
DSSLCEYJQQSHEG-UHFFFAOYSA-N n-[2-(trifluoromethyl)phenyl]adamantane-1-carboxamide Chemical compound FC(F)(F)C1=CC=CC=C1NC(=O)C1(C2)CC(C3)CC2CC3C1 DSSLCEYJQQSHEG-UHFFFAOYSA-N 0.000 claims description 2
YNUMZAUJPFCUSI-UHFFFAOYSA-N n-[2-[1-(1,3-benzodioxol-5-yl)-3-(furan-2-yl)-3-oxopropyl]sulfanylphenyl]acetamide Chemical compound CC(=O)NC1=CC=CC=C1SC(C=1C=C2OCOC2=CC=1)CC(=O)C1=CC=CO1 YNUMZAUJPFCUSI-UHFFFAOYSA-N 0.000 claims description 2
UYCZHBLVHUBVTK-UHFFFAOYSA-N n-[2-[2-(4-bromophenyl)-2-oxoethyl]sulfanyl-1,3-benzothiazol-6-yl]acetamide Chemical compound S1C2=CC(NC(=O)C)=CC=C2N=C1SCC(=O)C1=CC=C(Br)C=C1 UYCZHBLVHUBVTK-UHFFFAOYSA-N 0.000 claims description 2
KDFZSGMYXOGMIO-UHFFFAOYSA-N n-[2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-1,3-benzothiazol-6-yl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)NC1=CC=C(N=C(SCC(=O)NC2CCCCC2)S2)C2=C1 KDFZSGMYXOGMIO-UHFFFAOYSA-N 0.000 claims description 2
BIEBTXYZDFEXFI-UHFFFAOYSA-N n-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]ethylamino]-2-oxoethyl]-4-methyl-n-prop-2-ynylcyclohexane-1-carboxamide Chemical compound C1CC(C)CCC1C(=O)N(CC#C)CC(=O)NCCSCC1=C(F)C=CC=C1Cl BIEBTXYZDFEXFI-UHFFFAOYSA-N 0.000 claims description 2
BIVUOICGADPWOS-UHFFFAOYSA-N n-[2-[4-(3,4-dihydro-1h-isoquinolin-2-ylsulfonyl)phenyl]ethyl]acetamide Chemical compound C1=CC(CCNC(=O)C)=CC=C1S(=O)(=O)N1CC2=CC=CC=C2CC1 BIVUOICGADPWOS-UHFFFAOYSA-N 0.000 claims description 2
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FAAOHNFHEPYQPZ-UHFFFAOYSA-N n-[3-methyl-1-oxo-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)pentan-2-yl]cyclohexanecarboxamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C(C(C)CC)NC(=O)C1CCCCC1 FAAOHNFHEPYQPZ-UHFFFAOYSA-N 0.000 claims description 2
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NCUSGHYMFPTESZ-UHFFFAOYSA-N n-[4-(2-methylpiperidin-1-yl)sulfonylphenyl]acetamide Chemical compound CC1CCCCN1S(=O)(=O)C1=CC=C(NC(C)=O)C=C1 NCUSGHYMFPTESZ-UHFFFAOYSA-N 0.000 claims description 2
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QVYNJEKIYOVTPN-UHFFFAOYSA-N 1-(1-adamantyl)-2-(benzylamino)ethanone Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)CNCC1=CC=CC=C1 QVYNJEKIYOVTPN-UHFFFAOYSA-N 0.000 claims 1
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OOEQWCOFVOVUKD-UHFFFAOYSA-N 1-(3-azabicyclo[3.2.2]nonan-3-yl)-2-(1-methylindol-3-yl)ethanone Chemical compound C1CC(C2)CCC1CN2C(=O)CC1=CN(C)C2=CC=CC=C21 OOEQWCOFVOVUKD-UHFFFAOYSA-N 0.000 claims 1
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WLOBCFIHIQQBKX-UHFFFAOYSA-N 1-(4-aminophenyl)-n-cyclohexyl-n,5-dimethylpyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC(N)=CC=2)C(C)=C1C(=O)N(C)C1CCCCC1 WLOBCFIHIQQBKX-UHFFFAOYSA-N 0.000 claims 1
RNJWUQAUYSZDEG-UHFFFAOYSA-N 1-(4-bromophenyl)-2-[[4-(furan-2-ylmethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(Br)=CC=C1C(=O)CSC(N1CC=2OC=CC=2)=NN=C1C1=CC=NC=C1 RNJWUQAUYSZDEG-UHFFFAOYSA-N 0.000 claims 1
LABLZKSZGSYJKL-UHFFFAOYSA-N 1-(4-bromophenyl)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound N=1N=C(C=2OC=CC=2)N(C)C=1SCC(=O)C1=CC=C(Br)C=C1 LABLZKSZGSYJKL-UHFFFAOYSA-N 0.000 claims 1
ZUPUABHOCRSLRE-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[[4-methyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(C)=CC=C1C(N1C)=NN=C1SCC(=O)C1=CC=C(Cl)C=C1 ZUPUABHOCRSLRE-UHFFFAOYSA-N 0.000 claims 1
ROIJMAYXBGSVHD-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[[4-methyl-5-[4-(trifluoromethyl)pyridin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound N=1N=C(C=2C(=CC=NC=2)C(F)(F)F)N(C)C=1SCC(=O)C1=CC=C(Cl)C=C1 ROIJMAYXBGSVHD-UHFFFAOYSA-N 0.000 claims 1
SNVPQIRFGLLEPM-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-cyclohexyl-n,5-dimethylpyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC(Cl)=CC=2)C(C)=C1C(=O)N(C)C1CCCCC1 SNVPQIRFGLLEPM-UHFFFAOYSA-N 0.000 claims 1
TXOIGTCLNINOIR-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-cyclohexyl-n-methyl-5-(trifluoromethyl)pyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC(Cl)=CC=2)C(C(F)(F)F)=C1C(=O)N(C)C1CCCCC1 TXOIGTCLNINOIR-UHFFFAOYSA-N 0.000 claims 1
VQDYEQMWMKSMOT-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-cyclohexyl-n-methyl-5-propylpyrazole-4-carboxamide Chemical compound CCCC1=C(C(=O)N(C)C2CCCCC2)C=NN1C1=CC=C(Cl)C=C1 VQDYEQMWMKSMOT-UHFFFAOYSA-N 0.000 claims 1
ARSGBHLXHQNDKF-UHFFFAOYSA-N 1-(4-fluorophenyl)-2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]ethanone Chemical compound N=1N=C(C=2C=CC=CC=2)N(C)C=1SCC(=O)C1=CC=C(F)C=C1 ARSGBHLXHQNDKF-UHFFFAOYSA-N 0.000 claims 1
FITANMHEOCKQFD-UHFFFAOYSA-N 1-(4-fluorophenyl)-4-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]butan-1-one;2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone Chemical compound N=1N=C(C=2C=CC=CC=2)N(C)C=1SCCCC(=O)C1=CC=C(F)C=C1.CN1C(SCC(=O)C=2C=C3CCCCC3=CC=2)=NN=C1C1=CC=CC=C1 FITANMHEOCKQFD-UHFFFAOYSA-N 0.000 claims 1
JGMZKVWWDYIGBR-UHFFFAOYSA-N 1-(4-methoxyphenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 JGMZKVWWDYIGBR-UHFFFAOYSA-N 0.000 claims 1
LWBSCBZYYQRHKA-UHFFFAOYSA-N 1-(4-methoxyphenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C LWBSCBZYYQRHKA-UHFFFAOYSA-N 0.000 claims 1
XXMKZAKAWTXDHT-UHFFFAOYSA-N 1-(4-methoxyphenyl)-2-[[4-methyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1C)=NN=C1C1=CC=C([N+]([O-])=O)C=C1 XXMKZAKAWTXDHT-UHFFFAOYSA-N 0.000 claims 1
NMKQVFRVDXXVSD-UHFFFAOYSA-N 1-(4-methoxyphenyl)-2-[[5-phenyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 NMKQVFRVDXXVSD-UHFFFAOYSA-N 0.000 claims 1
CTPKJVXHHPQCCL-UHFFFAOYSA-N 1-(4-methylphenyl)-2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]ethanone Chemical compound C1=CC(C)=CC=C1C(=O)CSC(N1C)=NN=C1C1=CC=CC=C1 CTPKJVXHHPQCCL-UHFFFAOYSA-N 0.000 claims 1
HMHFTZDXVSPCRP-UHFFFAOYSA-N 1-(4-methylsulfonylphenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 HMHFTZDXVSPCRP-UHFFFAOYSA-N 0.000 claims 1
YMPYPNJQIXNYQP-UHFFFAOYSA-N 1-(4-methylsulfonylphenyl)-2-[[5-phenyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 YMPYPNJQIXNYQP-UHFFFAOYSA-N 0.000 claims 1
JHPVFCZLMIXTIE-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-2-[[4-methyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound COC1=CC=C(Cl)C=C1C(=O)CSC(N1C)=NN=C1C1=CC=C(C)C=C1 JHPVFCZLMIXTIE-UHFFFAOYSA-N 0.000 claims 1
BKYKMPRQCCFNST-UHFFFAOYSA-N 1-[(2,4-dichlorophenyl)methyl]-3-(4-ethyl-5-phenacylsulfanyl-1,2,4-triazol-3-yl)pyridin-2-one Chemical compound N=1N=C(C=2C(N(CC=3C(=CC(Cl)=CC=3)Cl)C=CC=2)=O)N(CC)C=1SCC(=O)C1=CC=CC=C1 BKYKMPRQCCFNST-UHFFFAOYSA-N 0.000 claims 1
WNEFRNIVCOKGGQ-UHFFFAOYSA-N 1-[2-[3-(2-methoxyethylsulfanyl)-5-(2-methoxyphenyl)-1,2,4-triazol-4-yl]ethyl]piperidine Chemical compound C1CCCCN1CCN1C(SCCOC)=NN=C1C1=CC=CC=C1OC WNEFRNIVCOKGGQ-UHFFFAOYSA-N 0.000 claims 1
CIBFVRRYMUZMST-UHFFFAOYSA-N 1-[2-[3-(2-methoxyethylsulfanyl)-5-thiophen-2-yl-1,2,4-triazol-4-yl]ethyl]piperidine Chemical compound C1CCCCN1CCN1C(SCCOC)=NN=C1C1=CC=CS1 CIBFVRRYMUZMST-UHFFFAOYSA-N 0.000 claims 1
YXAUVISGESVXOT-UHFFFAOYSA-N 1-[3-(4-methylphenyl)-1-adamantyl]-2-morpholin-4-ylethanone Chemical compound C1=CC(C)=CC=C1C1(C2)CC(C3)(C(=O)CN4CCOCC4)CC2CC3C1 YXAUVISGESVXOT-UHFFFAOYSA-N 0.000 claims 1
FFAIDMIJFPVFBB-UHFFFAOYSA-N 1-[3-(4-methylphenyl)-1-adamantyl]-2-pyrrolidin-1-ylethanone Chemical compound C1=CC(C)=CC=C1C1(C2)CC(C3)(C(=O)CN4CCCC4)CC2CC3C1 FFAIDMIJFPVFBB-UHFFFAOYSA-N 0.000 claims 1
JQVYWCHUEKNOEK-UHFFFAOYSA-N 1-[3-acetyl-2-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indol-3-yl]-2h-imidazol-1-yl]ethanone Chemical compound CC(=O)N1C=CN(C(C)=O)C1C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 JQVYWCHUEKNOEK-UHFFFAOYSA-N 0.000 claims 1
QIGHDXZWNDJYHM-UHFFFAOYSA-N 1-[4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]pyrrolidine-2,5-dione Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1N1C(=O)CCC1=O QIGHDXZWNDJYHM-UHFFFAOYSA-N 0.000 claims 1
GFPFBPJOTGRTDY-UHFFFAOYSA-N 1-[4-[5-(1-adamantyl)triazol-1-yl]phenyl]-2-anilinoethanone Chemical compound C=1C=C(N2C(=CN=N2)C23CC4CC(CC(C4)C2)C3)C=CC=1C(=O)CNC1=CC=CC=C1 GFPFBPJOTGRTDY-UHFFFAOYSA-N 0.000 claims 1
CGIJZTOWSYVIPU-UHFFFAOYSA-N 1-[[5-(2-hydroxyphenyl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]propan-2-one Chemical compound C=1C=CC=CC=1CCN1C(SCC(=O)C)=NN=C1C1=CC=CC=C1O CGIJZTOWSYVIPU-UHFFFAOYSA-N 0.000 claims 1
YUJUIPBGXOQXKA-UHFFFAOYSA-N 1-ethyl-3-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indol-3-yl]pyrrolidine-2,5-dione Chemical compound O=C1N(CC)C(=O)CC1C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 YUJUIPBGXOQXKA-UHFFFAOYSA-N 0.000 claims 1
WDFXDCDTBGETBZ-UHFFFAOYSA-N 1-methyl-n-(2-methylpiperidin-1-yl)indole-3-carboxamide Chemical compound CC1CCCCN1NC(=O)C1=CN(C)C2=CC=CC=C12 WDFXDCDTBGETBZ-UHFFFAOYSA-N 0.000 claims 1
SRUYSSQAJHSVRB-UHFFFAOYSA-N 1-methyl-n-(2-oxoazepan-3-yl)indole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NC1CCCCNC1=O SRUYSSQAJHSVRB-UHFFFAOYSA-N 0.000 claims 1
MDCYTDPPZISTPR-UHFFFAOYSA-N 1-phenyl-2-[[4-(2-phenylethyl)-5-pyridin-3-yl-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C=1C=CC=CC=1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 MDCYTDPPZISTPR-UHFFFAOYSA-N 0.000 claims 1
XNVSRSJSSNLZHI-UHFFFAOYSA-N 1-phenyl-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C=1C=CC=CC=1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 XNVSRSJSSNLZHI-UHFFFAOYSA-N 0.000 claims 1
PVWFSMQYLPNHNC-UHFFFAOYSA-N 1-phenyl-2-[[5-phenyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone Chemical compound C=1C=CC=CC=1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 PVWFSMQYLPNHNC-UHFFFAOYSA-N 0.000 claims 1
NKMVIVBZSDPXIO-UHFFFAOYSA-N 1h-imidazol-5-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CNC=N1 NKMVIVBZSDPXIO-UHFFFAOYSA-N 0.000 claims 1
RPUJVSJHGXHSGV-UHFFFAOYSA-N 1h-indol-2-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=CC=C2NC(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CC2=C1 RPUJVSJHGXHSGV-UHFFFAOYSA-N 0.000 claims 1
RNBNCLUSOOUPDD-UHFFFAOYSA-N 1h-indol-3-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=CC=C2C(C(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1 RNBNCLUSOOUPDD-UHFFFAOYSA-N 0.000 claims 1
URZDFIWYIIBQNA-UHFFFAOYSA-N 1h-indol-5-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=C2NC=CC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 URZDFIWYIIBQNA-UHFFFAOYSA-N 0.000 claims 1
MQMVUBXPIHNHTG-UHFFFAOYSA-N 1h-indol-5-yl-(4-phenylpiperidin-1-yl)methanone Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N(CC1)CCC1C1=CC=CC=C1 MQMVUBXPIHNHTG-UHFFFAOYSA-N 0.000 claims 1
DIVUGLHALPBSGO-UHFFFAOYSA-N 1h-indol-5-yl-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N(CC1)CCC1N1CCCC1 DIVUGLHALPBSGO-UHFFFAOYSA-N 0.000 claims 1
MGXIIXQIKRNOLY-UHFFFAOYSA-N 1h-indol-6-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1=C2C=CNC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 MGXIIXQIKRNOLY-UHFFFAOYSA-N 0.000 claims 1
YXELWVOQOFNVTK-UHFFFAOYSA-N 1h-indol-7-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CC=CC2=C1NC=C2 YXELWVOQOFNVTK-UHFFFAOYSA-N 0.000 claims 1
XOZFIDFWSRLTET-UHFFFAOYSA-N 2,4-dichloro-n-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)-n-methylbenzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)C(CC1)CCC21OCC(C)(C)CO2 XOZFIDFWSRLTET-UHFFFAOYSA-N 0.000 claims 1
XDMKZNARJRZIFT-UHFFFAOYSA-N 2,4-dichloro-n-methyl-n-(4-oxocyclohexyl)benzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)C1CCC(=O)CC1 XDMKZNARJRZIFT-UHFFFAOYSA-N 0.000 claims 1
BPFIBMDESXSKSD-UHFFFAOYSA-N 2-(1-methylindol-3-yl)-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)ethanone Chemical compound C12=CC=CC=C2N(C)C=C1CC(=O)N1C(CC(C)(C)C2)CC2(C)C1 BPFIBMDESXSKSD-UHFFFAOYSA-N 0.000 claims 1
ZZVHFDYCBPKARA-UHFFFAOYSA-N 2-(1h-indol-3-yl)-1-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)ethanone Chemical compound C1=CC=C2C(CC(=O)N3C4CC(CC(C)(C)C4)(C3)C)=CNC2=C1 ZZVHFDYCBPKARA-UHFFFAOYSA-N 0.000 claims 1
MLJSAZNRAKTZKO-UHFFFAOYSA-N 2-(2-nitrophenyl)acetamide Chemical compound NC(=O)CC1=CC=CC=C1[N+]([O-])=O MLJSAZNRAKTZKO-UHFFFAOYSA-N 0.000 claims 1
BWSOOJDEOGMMRQ-UHFFFAOYSA-N 2-(4-aminophenyl)-n-cyclohexyl-n-methyl-3h-benzimidazole-5-carboxamide Chemical compound C=1C=C2NC(C=3C=CC(N)=CC=3)=NC2=CC=1C(=O)N(C)C1CCCCC1 BWSOOJDEOGMMRQ-UHFFFAOYSA-N 0.000 claims 1
DOURZFDBZLGWKZ-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-n-[(3-hydroxyphenyl)methyl]-n-(4-methylpentyl)acetamide Chemical compound C=1C=C(O)C=CC=1CC(=O)N(CCCC(C)C)CC1=CC=CC(O)=C1 DOURZFDBZLGWKZ-UHFFFAOYSA-N 0.000 claims 1
ZCTNFXZCSTURDF-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-n-[(4-hydroxyphenyl)methyl]-n-(2-methylpropyl)acetamide Chemical compound C=1C=C(O)C=CC=1CC(=O)N(CC(C)C)CC1=CC=C(O)C=C1 ZCTNFXZCSTURDF-UHFFFAOYSA-N 0.000 claims 1
MCZBGYFGRFIOOM-UHFFFAOYSA-N 2-(5-benzylsulfanyl-4-ethyl-1,2,4-triazol-3-yl)phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=CC=C1 MCZBGYFGRFIOOM-UHFFFAOYSA-N 0.000 claims 1
TVLMNUCPOGGEFL-UHFFFAOYSA-N 2-(6,6-dimethyl-7,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)phenol Chemical compound N12CC(C)(C)CNC2=NN=C1C1=CC=CC=C1O TVLMNUCPOGGEFL-UHFFFAOYSA-N 0.000 claims 1
ZDZWYBQALASASL-UHFFFAOYSA-N 2-(tert-butylamino)-1-[3-(4-methylphenyl)-1-adamantyl]ethanone Chemical compound C1=CC(C)=CC=C1C1(C2)CC(C3)(C(=O)CNC(C)(C)C)CC2CC3C1 ZDZWYBQALASASL-UHFFFAOYSA-N 0.000 claims 1
PXFCPVKUQUIYBH-UHFFFAOYSA-N 2-[(4,5-dibenzyl-1,2,4-triazol-3-yl)sulfanyl]-n-(1,3-thiazol-2-yl)acetamide Chemical compound N=1C=CSC=1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1CC1=CC=CC=C1 PXFCPVKUQUIYBH-UHFFFAOYSA-N 0.000 claims 1
JPQYHLMHOCTCRD-UHFFFAOYSA-N 2-[(4,5-dibenzyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-nitrophenyl)acetamide Chemical compound C1=CC([N+](=O)[O-])=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1CC1=CC=CC=C1 JPQYHLMHOCTCRD-UHFFFAOYSA-N 0.000 claims 1
CAMRZLGQEARZNA-UHFFFAOYSA-N 2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethanone Chemical compound C=1C=CC=CC=1CN1C(C)=NN=C1SCC(=O)C1=CC=CC=C1 CAMRZLGQEARZNA-UHFFFAOYSA-N 0.000 claims 1
LBAJRNIKSGBRKY-UHFFFAOYSA-N 2-[(4-benzyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(1,3-thiazol-2-yl)acetamide Chemical compound N=1C=CSC=1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 LBAJRNIKSGBRKY-UHFFFAOYSA-N 0.000 claims 1
AAVBZIRJRXJTRJ-UHFFFAOYSA-N 2-[(4-benzyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound [O-][N+](=O)C1=CC=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 AAVBZIRJRXJTRJ-UHFFFAOYSA-N 0.000 claims 1
NMDMRHKNAHCKIN-UHFFFAOYSA-N 2-[(4-benzyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-methoxy-2-nitrophenyl)acetamide Chemical compound [O-][N+](=O)C1=CC(OC)=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 NMDMRHKNAHCKIN-UHFFFAOYSA-N 0.000 claims 1
UCVZELOSGRELQR-UHFFFAOYSA-N 2-[(4-benzyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(5-methyl-1,3-thiazol-2-yl)acetamide Chemical compound S1C(C)=CN=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 UCVZELOSGRELQR-UHFFFAOYSA-N 0.000 claims 1
XYICGIWIAUBMFT-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(2,4-dimethylphenyl)acetamide Chemical compound CC1=CC(C)=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 XYICGIWIAUBMFT-UHFFFAOYSA-N 0.000 claims 1
NTRXTQXPZGPAEP-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(2,5-dichlorophenyl)acetamide Chemical compound ClC1=CC=C(Cl)C(NC(=O)CSC=2N(C(C=3C=NC=CC=3)=NN=2)CC=2C=CC=CC=2)=C1 NTRXTQXPZGPAEP-UHFFFAOYSA-N 0.000 claims 1
ZHCMLMMMHDUQAK-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-chlorophenyl)acetamide Chemical compound ClC1=CC=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 ZHCMLMMMHDUQAK-UHFFFAOYSA-N 0.000 claims 1
BOHGBGJEZYUOGV-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(3-chloro-4-methylphenyl)acetamide Chemical compound C1=C(Cl)C(C)=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 BOHGBGJEZYUOGV-UHFFFAOYSA-N 0.000 claims 1
RXEQJKYCIPBBON-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(3-chlorophenyl)acetamide Chemical compound ClC1=CC=CC(NC(=O)CSC=2N(C(C=3C=NC=CC=3)=NN=2)CC=2C=CC=CC=2)=C1 RXEQJKYCIPBBON-UHFFFAOYSA-N 0.000 claims 1
KGKIVMCUBOBICZ-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-fluorophenyl)acetamide Chemical compound C1=CC(F)=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 KGKIVMCUBOBICZ-UHFFFAOYSA-N 0.000 claims 1
HMPMXRWESNIDBX-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 HMPMXRWESNIDBX-UHFFFAOYSA-N 0.000 claims 1
WYYUHUCKFFEZGC-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-nitrophenyl)acetamide Chemical compound C1=CC([N+](=O)[O-])=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 WYYUHUCKFFEZGC-UHFFFAOYSA-N 0.000 claims 1
MALAUNNEZDDMRB-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-nitrophenyl)propanamide Chemical compound C=1C=C([N+]([O-])=O)C=CC=1NC(=O)C(C)SC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 MALAUNNEZDDMRB-UHFFFAOYSA-N 0.000 claims 1
KHAWECWHKUKBNB-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide Chemical compound S1C(CC)=NN=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 KHAWECWHKUKBNB-UHFFFAOYSA-N 0.000 claims 1
MSNONISGFCZKJO-UHFFFAOYSA-N 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n-phenylacetamide Chemical compound C=1C=CC=CC=1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 MSNONISGFCZKJO-UHFFFAOYSA-N 0.000 claims 1
DWGCUVVVRGHFLS-UHFFFAOYSA-N 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile Chemical compound N#CC1=CC=CC=C1CSC(N1C2CC2)=NN=C1C1=CC=CS1 DWGCUVVVRGHFLS-UHFFFAOYSA-N 0.000 claims 1
FIRTVNRJWCZONW-UHFFFAOYSA-N 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]pyridine Chemical compound C=1C=CC=NC=1CSC(N1C2CC2)=NN=C1C1=CC=CS1 FIRTVNRJWCZONW-UHFFFAOYSA-N 0.000 claims 1
IZEIJCICDFBHJZ-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)C1=CC=C(OC)C=C1 IZEIJCICDFBHJZ-UHFFFAOYSA-N 0.000 claims 1
YDXZAZIBEPHVBH-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)C1=CC=C(C)C=C1 YDXZAZIBEPHVBH-UHFFFAOYSA-N 0.000 claims 1
VQZXMZKKRCWFEH-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylsulfonylphenyl)ethanone Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)C1=CC=C(S(C)(=O)=O)C=C1 VQZXMZKKRCWFEH-UHFFFAOYSA-N 0.000 claims 1
NYRMEOIXCWFRCR-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-1-pyridin-3-ylethanone Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)C1=CC=CN=C1 NYRMEOIXCWFRCR-UHFFFAOYSA-N 0.000 claims 1
COPOUVWMGZKHBX-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(1,3-thiazol-2-yl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=NC=CS1 COPOUVWMGZKHBX-UHFFFAOYSA-N 0.000 claims 1
XXXVUIMIIDCHLC-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-methoxy-4-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1OC XXXVUIMIIDCHLC-UHFFFAOYSA-N 0.000 claims 1
HHDUWNVUOSHJCQ-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-methoxyphenyl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1OC HHDUWNVUOSHJCQ-UHFFFAOYSA-N 0.000 claims 1
HRCZOOXRIROALG-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-methyl-4-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1C HRCZOOXRIROALG-UHFFFAOYSA-N 0.000 claims 1
HSYYQEYXSAOILU-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1[N+]([O-])=O HSYYQEYXSAOILU-UHFFFAOYSA-N 0.000 claims 1
GWDQNILHJYBECH-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-phenylphenyl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1C1=CC=CC=C1 GWDQNILHJYBECH-UHFFFAOYSA-N 0.000 claims 1
ZQHHQRSCAFOVKR-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-fluorophenyl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(F)C=C1 ZQHHQRSCAFOVKR-UHFFFAOYSA-N 0.000 claims 1
KLDXTEQXASFNGL-UHFFFAOYSA-N 2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-[2-(trifluoromethyl)phenyl]acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1C(F)(F)F KLDXTEQXASFNGL-UHFFFAOYSA-N 0.000 claims 1
AOYSFQOMUDJRNG-UHFFFAOYSA-N 2-[(4-ethyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-n,n-diphenylpropanamide Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SC(C)C(=O)N(C=1C=CC=CC=1)C1=CC=CC=C1 AOYSFQOMUDJRNG-UHFFFAOYSA-N 0.000 claims 1
ZLHJBWWTEFXITQ-UHFFFAOYSA-N 2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC(=O)C1=CC=C(OC)C=C1 ZLHJBWWTEFXITQ-UHFFFAOYSA-N 0.000 claims 1
YLNNBXZYUULBOF-UHFFFAOYSA-N 2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylsulfonylphenyl)ethanone Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC(=O)C1=CC=C(S(C)(=O)=O)C=C1 YLNNBXZYUULBOF-UHFFFAOYSA-N 0.000 claims 1
WHFGTWKZLDSSNT-UHFFFAOYSA-N 2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC(=O)C1=CC=CC=C1 WHFGTWKZLDSSNT-UHFFFAOYSA-N 0.000 claims 1
SQIIVHOIAJVGMN-UHFFFAOYSA-N 2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-1-pyridin-3-ylethanone Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC(=O)C1=CC=CN=C1 SQIIVHOIAJVGMN-UHFFFAOYSA-N 0.000 claims 1
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OMLATOXNVQCZBD-UHFFFAOYSA-N 2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2C=CC=CC=2)N(C)C=1SCC(=O)C1=CC=CC=C1 OMLATOXNVQCZBD-UHFFFAOYSA-N 0.000 claims 1
WNMCGLNHMAPWMX-UHFFFAOYSA-N 2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-n-(1,3-thiazol-2-yl)acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(C)C=1SCC(=O)NC1=NC=CS1 WNMCGLNHMAPWMX-UHFFFAOYSA-N 0.000 claims 1
CBVQLFRFSZOZJB-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC(OC)=CC=2)N(CC)C=1CC1=CC=CC=C1 CBVQLFRFSZOZJB-UHFFFAOYSA-N 0.000 claims 1
LJRGXZXJRYSIEN-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-bromo-4-methylphenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=CC(C)=CC=2)Br)N(CC)C=1CC1=CC=CC=C1 LJRGXZXJRYSIEN-UHFFFAOYSA-N 0.000 claims 1
MWSZUKAKMYRTLW-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-chlorophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=CC=CC=2)Cl)N(CC)C=1CC1=CC=CC=C1 MWSZUKAKMYRTLW-UHFFFAOYSA-N 0.000 claims 1
VKDGBSZGTHCTJW-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-methoxy-4-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=CC(=CC=2)[N+]([O-])=O)OC)N(CC)C=1CC1=CC=CC=C1 VKDGBSZGTHCTJW-UHFFFAOYSA-N 0.000 claims 1
OIFGDCZYGQDBGD-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-methyl-4-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=CC(=CC=2)[N+]([O-])=O)C)N(CC)C=1CC1=CC=CC=C1 OIFGDCZYGQDBGD-UHFFFAOYSA-N 0.000 claims 1
LXUKLKRRKKKBBS-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(3-chloro-2-methylphenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=C(Cl)C=CC=2)C)N(CC)C=1CC1=CC=CC=C1 LXUKLKRRKKKBBS-UHFFFAOYSA-N 0.000 claims 1
COZFFPUXXWBNCN-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-bromophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(Br)=CC=2)N(CC)C=1CC1=CC=CC=C1 COZFFPUXXWBNCN-UHFFFAOYSA-N 0.000 claims 1
WGLDXNACFBBKRB-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-chloro-3-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=C(C(Cl)=CC=2)[N+]([O-])=O)N(CC)C=1CC1=CC=CC=C1 WGLDXNACFBBKRB-UHFFFAOYSA-N 0.000 claims 1
ZQVLGOHYAIFHDM-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-ethylphenyl)acetamide Chemical compound C1=CC(CC)=CC=C1NC(=O)CSC(N1CC)=NN=C1CC1=CC=CC=C1 ZQVLGOHYAIFHDM-UHFFFAOYSA-N 0.000 claims 1
JZKHALMWMRFZDX-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-fluorophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(F)=CC=2)N(CC)C=1CC1=CC=CC=C1 JZKHALMWMRFZDX-UHFFFAOYSA-N 0.000 claims 1
NSKQZRLLDFIAMR-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-methoxyphenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(OC)=CC=2)N(CC)C=1CC1=CC=CC=C1 NSKQZRLLDFIAMR-UHFFFAOYSA-N 0.000 claims 1
CIRKKMVEODCIGM-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-methyl-3-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=C(C(C)=CC=2)[N+]([O-])=O)N(CC)C=1CC1=CC=CC=C1 CIRKKMVEODCIGM-UHFFFAOYSA-N 0.000 claims 1
JLXMMQVBTYKLIE-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1CC1=CC=CC=C1 JLXMMQVBTYKLIE-UHFFFAOYSA-N 0.000 claims 1
IWLQACYNQSZNSF-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide Chemical compound S1C(CC)=NN=C1NC(=O)CSC(N1CC)=NN=C1CC1=CC=CC=C1 IWLQACYNQSZNSF-UHFFFAOYSA-N 0.000 claims 1
IVHLDCBGHULXFL-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-[2-(trifluoromethyl)phenyl]acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=CC=CC=2)C(F)(F)F)N(CC)C=1CC1=CC=CC=C1 IVHLDCBGHULXFL-UHFFFAOYSA-N 0.000 claims 1
RSZFJCOIBSAZKN-UHFFFAOYSA-N 2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-phenylacetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC=CC=2)N(CC)C=1CC1=CC=CC=C1 RSZFJCOIBSAZKN-UHFFFAOYSA-N 0.000 claims 1
PBFPARZCOASPBZ-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-(3,4-dihydro-2h-quinolin-1-yl)ethanone Chemical compound N=1N=C(SCC(=O)N2C3=CC=CC=C3CCC2)N(C)C=1CC1=CC=CC=C1 PBFPARZCOASPBZ-UHFFFAOYSA-N 0.000 claims 1
FCTPVQPOXUISFD-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound C1=CC(C)=CC=C1C(=O)CSC(N1C)=NN=C1CC1=CC=CC=C1 FCTPVQPOXUISFD-UHFFFAOYSA-N 0.000 claims 1
RCEFWFLUWHELRI-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC=CC=2)N(C)C=1CC1=CC=CC=C1 RCEFWFLUWHELRI-UHFFFAOYSA-N 0.000 claims 1
MHMBYEPWGYLVPR-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-bromo-4-methylphenyl)acetamide Chemical compound BrC1=CC(C)=CC=C1NC(=O)CSC(N1C)=NN=C1CC1=CC=CC=C1 MHMBYEPWGYLVPR-UHFFFAOYSA-N 0.000 claims 1
XXFINZOWWNSDAW-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=CC=CC=2)[N+]([O-])=O)N(C)C=1CC1=CC=CC=C1 XXFINZOWWNSDAW-UHFFFAOYSA-N 0.000 claims 1
JRGRZUDIEJDCHB-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)acetamide Chemical compound N=1N=C(SCC(=O)NC2=C(C=3CCCCC=3S2)C#N)N(C)C=1CC1=CC=CC=C1 JRGRZUDIEJDCHB-UHFFFAOYSA-N 0.000 claims 1
KICJYMHLPJCPQH-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-bromophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(Br)=CC=2)N(C)C=1CC1=CC=CC=C1 KICJYMHLPJCPQH-UHFFFAOYSA-N 0.000 claims 1
WAJKAVZEYXRYGS-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-chlorophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(Cl)=CC=2)N(C)C=1CC1=CC=CC=C1 WAJKAVZEYXRYGS-UHFFFAOYSA-N 0.000 claims 1
SBBSBISWIJKQAZ-UHFFFAOYSA-N 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-iodophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(I)=CC=2)N(C)C=1CC1=CC=CC=C1 SBBSBISWIJKQAZ-UHFFFAOYSA-N 0.000 claims 1
QZMSZPWFQDKEHJ-UHFFFAOYSA-N 2-[(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)methyl]-4h-1,4-benzothiazin-3-one Chemical compound CN1C(CC2C(NC3=CC=CC=C3S2)=O)=NN=C1SCC1=CC=CC=C1 QZMSZPWFQDKEHJ-UHFFFAOYSA-N 0.000 claims 1
ZYDQGTNFFKJZLA-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)C1=CC=C(OC)C=C1 ZYDQGTNFFKJZLA-UHFFFAOYSA-N 0.000 claims 1
QANHFZMZEGPXSC-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)C1=CC=CC=C1 QANHFZMZEGPXSC-UHFFFAOYSA-N 0.000 claims 1
RJFWWKKBHYIMDW-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-methyl-4-nitrophenyl)acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1C RJFWWKKBHYIMDW-UHFFFAOYSA-N 0.000 claims 1
WJSFRZIWYCRWDI-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=CC=C1[N+]([O-])=O WJSFRZIWYCRWDI-UHFFFAOYSA-N 0.000 claims 1
WNVMRZOLJARALA-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(3-nitrophenyl)acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=CC([N+]([O-])=O)=C1 WNVMRZOLJARALA-UHFFFAOYSA-N 0.000 claims 1
IIKLXUMHNDYQQF-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-ethoxyphenyl)acetamide Chemical compound C1=CC(OCC)=CC=C1NC(=O)CSC(N1CC)=NN=C1C1CCCCC1 IIKLXUMHNDYQQF-UHFFFAOYSA-N 0.000 claims 1
DXERDAKIOVTIFN-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-methyl-3-nitrophenyl)acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=C(C)C([N+]([O-])=O)=C1 DXERDAKIOVTIFN-UHFFFAOYSA-N 0.000 claims 1
FBIFPUDWSYBGMN-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-nitrophenyl)acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1 FBIFPUDWSYBGMN-UHFFFAOYSA-N 0.000 claims 1
COJGVVNCUDFCKV-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-nitrophenyl)propanamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SC(C)C(=O)NC1=CC=C([N+]([O-])=O)C=C1 COJGVVNCUDFCKV-UHFFFAOYSA-N 0.000 claims 1
OXXLXHAZFARENP-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide Chemical compound S1C(CC)=NN=C1NC(=O)CSC(N1CC)=NN=C1C1CCCCC1 OXXLXHAZFARENP-UHFFFAOYSA-N 0.000 claims 1
DHCMBXNYCQDXLU-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-[3-(trifluoromethyl)phenyl]acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=CC(C(F)(F)F)=C1 DHCMBXNYCQDXLU-UHFFFAOYSA-N 0.000 claims 1
DXLJWUKMMDUAAG-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-naphthalen-1-ylacetamide Chemical compound CCN1C(SCC(=O)NC=2C3=CC=CC=C3C=CC=2)=NN=C1C1CCCCC1 DXLJWUKMMDUAAG-UHFFFAOYSA-N 0.000 claims 1
KVCLNAAPESALBU-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-n-phenylacetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=CC=C1 KVCLNAAPESALBU-UHFFFAOYSA-N 0.000 claims 1
WUVDSBMAURLEAZ-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1C)=NN=C1C1CCCCC1 WUVDSBMAURLEAZ-UHFFFAOYSA-N 0.000 claims 1
SJBSKRGOCIPQQT-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C2CCCCC2)N(C)C=1SCC(=O)C1=CC=CC=C1 SJBSKRGOCIPQQT-UHFFFAOYSA-N 0.000 claims 1
QEJQODUVUVQJMH-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(2-methyl-4-nitrophenyl)acetamide Chemical compound CC1=CC([N+]([O-])=O)=CC=C1NC(=O)CSC(N1C)=NN=C1C1CCCCC1 QEJQODUVUVQJMH-UHFFFAOYSA-N 0.000 claims 1
ACOXSXYLINCOOJ-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(3,4-dichlorophenyl)acetamide Chemical compound N=1N=C(C2CCCCC2)N(C)C=1SCC(=O)NC1=CC=C(Cl)C(Cl)=C1 ACOXSXYLINCOOJ-UHFFFAOYSA-N 0.000 claims 1
LJJXGTQNGLBJEV-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(3-nitrophenyl)acetamide Chemical compound N=1N=C(C2CCCCC2)N(C)C=1SCC(=O)NC1=CC=CC([N+]([O-])=O)=C1 LJJXGTQNGLBJEV-UHFFFAOYSA-N 0.000 claims 1
XIZYLFNKTSKZNN-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-iodo-2-methylphenyl)acetamide Chemical compound CC1=CC(I)=CC=C1NC(=O)CSC(N1C)=NN=C1C1CCCCC1 XIZYLFNKTSKZNN-UHFFFAOYSA-N 0.000 claims 1
LBTKHNWMHQXHGB-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1CCCCC1 LBTKHNWMHQXHGB-UHFFFAOYSA-N 0.000 claims 1
DPPSKBNKVDYAKX-UHFFFAOYSA-N 2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-n-phenylacetamide Chemical compound N=1N=C(C2CCCCC2)N(C)C=1SCC(=O)NC1=CC=CC=C1 DPPSKBNKVDYAKX-UHFFFAOYSA-N 0.000 claims 1
ZHONOIXVBFLUNK-UHFFFAOYSA-N 2-[4-(2-methoxyethyl)-5-(2-methoxyethylsulfanyl)-1,2,4-triazol-3-yl]-1-methylpiperidine Chemical compound COCCN1C(SCCOC)=NN=C1C1N(C)CCCC1 ZHONOIXVBFLUNK-UHFFFAOYSA-N 0.000 claims 1
QNYYKYDVCRJADV-UHFFFAOYSA-N 2-[4-(2-methoxyethyl)-5-(2-methoxyethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound COCCN1C(SCCOC)=NN=C1C1=CC=CC=C1O QNYYKYDVCRJADV-UHFFFAOYSA-N 0.000 claims 1
DBFZXNIOYMDGPC-UHFFFAOYSA-N 2-[4-(2-methoxyethyl)-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CCOC)C=1SCC1=CC=CC=N1 DBFZXNIOYMDGPC-UHFFFAOYSA-N 0.000 claims 1
JFJNSJBPRUNIHJ-UHFFFAOYSA-N 2-[4-(2-piperidin-1-ylethyl)-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound OC1=CC=CC=C1C(N1CCN2CCCCC2)=NN=C1SCC1=CC=CC=N1 JFJNSJBPRUNIHJ-UHFFFAOYSA-N 0.000 claims 1
HYIOYEXEHHOTRT-UHFFFAOYSA-N 2-[4-(3-methoxypropyl)-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CCCOC)C=1SCC1=CC=CC=N1 HYIOYEXEHHOTRT-UHFFFAOYSA-N 0.000 claims 1
FNLCUAJTUGOSBS-UHFFFAOYSA-N 2-[4-(cyclopropylmethyl)-5-(2-methoxyethylsulfanyl)-1,2,4-triazol-3-yl]-1-methylpiperidine Chemical compound C1CC1CN1C(SCCOC)=NN=C1C1CCCCN1C FNLCUAJTUGOSBS-UHFFFAOYSA-N 0.000 claims 1
BVKGZHNESWEZBH-UHFFFAOYSA-N 2-[4-(cyclopropylmethyl)-5-(2-methoxyethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound C1CC1CN1C(SCCOC)=NN=C1C1=CC=CC=C1O BVKGZHNESWEZBH-UHFFFAOYSA-N 0.000 claims 1
MNLIOEDPEDTPIH-UHFFFAOYSA-N 2-[4-(cyclopropylmethyl)-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound OC1=CC=CC=C1C(N1CC2CC2)=NN=C1SCC1=CC=CC=N1 MNLIOEDPEDTPIH-UHFFFAOYSA-N 0.000 claims 1
JTLLXTGXSYXFGS-UHFFFAOYSA-N 2-[4-cyclopropyl-5-(2-methoxyethylsulfanyl)-1,2,4-triazol-3-yl]-1-methylpiperidine Chemical compound C1CC1N1C(SCCOC)=NN=C1C1CCCCN1C JTLLXTGXSYXFGS-UHFFFAOYSA-N 0.000 claims 1
DWXHVTUOXMDSRV-UHFFFAOYSA-N 2-[4-cyclopropyl-5-(2-methoxyethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound C1CC1N1C(SCCOC)=NN=C1C1=CC=CC=C1O DWXHVTUOXMDSRV-UHFFFAOYSA-N 0.000 claims 1
WUSCLOLDRCUNRE-UHFFFAOYSA-N 2-[4-cyclopropyl-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]phenol Chemical compound OC1=CC=CC=C1C(N1C2CC2)=NN=C1SCC1=CC=CC=N1 WUSCLOLDRCUNRE-UHFFFAOYSA-N 0.000 claims 1
QLGVFLQRHXIJDO-UHFFFAOYSA-N 2-[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O QLGVFLQRHXIJDO-UHFFFAOYSA-N 0.000 claims 1
ZTIVMPXZJVAAJY-UHFFFAOYSA-N 2-[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O ZTIVMPXZJVAAJY-UHFFFAOYSA-N 0.000 claims 1
GJTWQDIJUBFBSJ-UHFFFAOYSA-N 2-[4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 GJTWQDIJUBFBSJ-UHFFFAOYSA-N 0.000 claims 1
TUGNHRLVKXOBPA-UHFFFAOYSA-N 2-[4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 TUGNHRLVKXOBPA-UHFFFAOYSA-N 0.000 claims 1
KSRPZEGSDPGTEG-UHFFFAOYSA-N 2-[4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=C(C)C=C1 KSRPZEGSDPGTEG-UHFFFAOYSA-N 0.000 claims 1
WJVLMPBAYGZROF-UHFFFAOYSA-N 2-[4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 WJVLMPBAYGZROF-UHFFFAOYSA-N 0.000 claims 1
ZUDCBCMSXZRDDS-UHFFFAOYSA-N 2-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 ZUDCBCMSXZRDDS-UHFFFAOYSA-N 0.000 claims 1
NYYAQIMMHUNUBK-UHFFFAOYSA-N 2-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 NYYAQIMMHUNUBK-UHFFFAOYSA-N 0.000 claims 1
LWNOEQJRDVDQBM-UHFFFAOYSA-N 2-[4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 LWNOEQJRDVDQBM-UHFFFAOYSA-N 0.000 claims 1
GTSUZRJCUKMHSE-UHFFFAOYSA-N 2-[4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 GTSUZRJCUKMHSE-UHFFFAOYSA-N 0.000 claims 1
KMTWAGYEIDEIFJ-UHFFFAOYSA-N 2-[4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 KMTWAGYEIDEIFJ-UHFFFAOYSA-N 0.000 claims 1
RDZOSHIUFUVJIK-UHFFFAOYSA-N 2-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O RDZOSHIUFUVJIK-UHFFFAOYSA-N 0.000 claims 1
MNMAXWCOHZMSRC-UHFFFAOYSA-N 2-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O MNMAXWCOHZMSRC-UHFFFAOYSA-N 0.000 claims 1
KCLMSKPHJFWGLT-UHFFFAOYSA-N 2-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 KCLMSKPHJFWGLT-UHFFFAOYSA-N 0.000 claims 1
QUKLUPQXVGHINW-UHFFFAOYSA-N 2-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 QUKLUPQXVGHINW-UHFFFAOYSA-N 0.000 claims 1
KLHCUYOHQHRXJT-UHFFFAOYSA-N 2-[4-ethyl-5-[[4-(thiadiazol-4-yl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 KLHCUYOHQHRXJT-UHFFFAOYSA-N 0.000 claims 1
GDCBRBDLEVSCMB-UHFFFAOYSA-N 2-[4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 GDCBRBDLEVSCMB-UHFFFAOYSA-N 0.000 claims 1
QDXABEWTQGXEKY-UHFFFAOYSA-N 2-[4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 QDXABEWTQGXEKY-UHFFFAOYSA-N 0.000 claims 1
UBNQYRRJVNGYFE-UHFFFAOYSA-N 2-[5-(2-methoxyethylsulfanyl)-4-(2-piperidin-1-ylethyl)-1,2,4-triazol-3-yl]phenol Chemical compound C1CCCCN1CCN1C(SCCOC)=NN=C1C1=CC=CC=C1O UBNQYRRJVNGYFE-UHFFFAOYSA-N 0.000 claims 1
ZGNBIWKKFDMVPK-UHFFFAOYSA-N 2-[5-(2-methoxyethylsulfanyl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]-1-methylpiperidine Chemical compound COCCCN1C(SCCOC)=NN=C1C1N(C)CCCC1 ZGNBIWKKFDMVPK-UHFFFAOYSA-N 0.000 claims 1
GFPRHIJUJNNSMM-UHFFFAOYSA-N 2-[5-(2-methoxyethylsulfanyl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]phenol Chemical compound COCCCN1C(SCCOC)=NN=C1C1=CC=CC=C1O GFPRHIJUJNNSMM-UHFFFAOYSA-N 0.000 claims 1
ZNWUQVNZPMRDGO-UHFFFAOYSA-N 2-[5-(2-morpholin-4-ylethylsulfanyl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]phenol Chemical compound OC1=CC=CC=C1C(N1CCC=2C=CC=CC=2)=NN=C1SCCN1CCOCC1 ZNWUQVNZPMRDGO-UHFFFAOYSA-N 0.000 claims 1
ODDJKPUTMQGORL-UHFFFAOYSA-N 2-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]acetamide Chemical compound C1=C2N(CC(N)=O)C=CC2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 ODDJKPUTMQGORL-UHFFFAOYSA-N 0.000 claims 1
ICAMFZGTGGJIOT-UHFFFAOYSA-N 2-[5-(cyclohexylmethylsulfanyl)-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1CCCCC1 ICAMFZGTGGJIOT-UHFFFAOYSA-N 0.000 claims 1
GVUVLSNZMGWSGD-UHFFFAOYSA-N 2-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl GVUVLSNZMGWSGD-UHFFFAOYSA-N 0.000 claims 1
ORJYMIDFCWMEOD-UHFFFAOYSA-N 2-[5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl ORJYMIDFCWMEOD-UHFFFAOYSA-N 0.000 claims 1
RZQGGELKZDOLPQ-UHFFFAOYSA-N 2-[5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 RZQGGELKZDOLPQ-UHFFFAOYSA-N 0.000 claims 1
IIKUPAABISOFBR-UHFFFAOYSA-N 2-[5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 IIKUPAABISOFBR-UHFFFAOYSA-N 0.000 claims 1
OTVOFYWDCZQTGH-UHFFFAOYSA-N 2-[5-[(4-bromophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 OTVOFYWDCZQTGH-UHFFFAOYSA-N 0.000 claims 1
MLVPXNHHTSMMFX-UHFFFAOYSA-N 2-[5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=CC=C1O MLVPXNHHTSMMFX-UHFFFAOYSA-N 0.000 claims 1
SATPLZDPPWUWBL-UHFFFAOYSA-N 2-[5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine;2-[5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1.CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=CC=N1 SATPLZDPPWUWBL-UHFFFAOYSA-N 0.000 claims 1
BUZUEAQKXXRHHX-UHFFFAOYSA-N 2-[[4-(2-methoxyethyl)-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C2N(CCCC2)C)N(CCOC)C=1SCC1=CC=CC=C1C#N BUZUEAQKXXRHHX-UHFFFAOYSA-N 0.000 claims 1
VRJCGUHXIVYUJK-UHFFFAOYSA-N 2-[[4-(2-methoxyethyl)-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound N=1N=C(C2N(CCCC2)C)N(CCOC)C=1SCC1=CC=CC=N1 VRJCGUHXIVYUJK-UHFFFAOYSA-N 0.000 claims 1
CDDRZDBYXZDANF-UHFFFAOYSA-N 2-[[4-(2-methoxyethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CCOC)C=1SCC1=CC=CC=C1C#N CDDRZDBYXZDANF-UHFFFAOYSA-N 0.000 claims 1
AAIBAWKSPDZOQE-UHFFFAOYSA-N 2-[[4-(2-methoxyethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CCOC)C=1SCC1=CC=CC=N1 AAIBAWKSPDZOQE-UHFFFAOYSA-N 0.000 claims 1
JHKXWKOBFAQZJH-UHFFFAOYSA-N 2-[[4-(2-methoxyethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2SC=CC=2)N(CCOC)C=1SCC1=CC=CC=C1C#N JHKXWKOBFAQZJH-UHFFFAOYSA-N 0.000 claims 1
BQOYHCFNYWYRSL-UHFFFAOYSA-N 2-[[4-(2-methoxyethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound N=1N=C(C=2SC=CC=2)N(CCOC)C=1SCC1=CC=CC=N1 BQOYHCFNYWYRSL-UHFFFAOYSA-N 0.000 claims 1
IMABNNILBXTTEB-UHFFFAOYSA-N 2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]-1-pyridin-3-ylethanone Chemical compound C=1C=CN=CC=1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 IMABNNILBXTTEB-UHFFFAOYSA-N 0.000 claims 1
UYJHAXNBUOMUFT-UHFFFAOYSA-N 2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]-n-(1,3-thiazol-2-yl)acetamide Chemical compound N=1C=CSC=1NC(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 UYJHAXNBUOMUFT-UHFFFAOYSA-N 0.000 claims 1
ZHBZQXVDOAMMBX-UHFFFAOYSA-N 2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]-n-[3-(trifluoromethyl)phenyl]acetamide Chemical compound FC(F)(F)C1=CC=CC(NC(=O)CSC=2N(C(C=3C=CN=CC=3)=NN=2)CCC=2C=CC=CC=2)=C1 ZHBZQXVDOAMMBX-UHFFFAOYSA-N 0.000 claims 1
IYCQTMVLDMLCJC-UHFFFAOYSA-N 2-[[4-(2-piperidin-1-ylethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N#CC1=CC=CC=C1CSC(N1CCN2CCCCC2)=NN=C1C1=CC=CS1 IYCQTMVLDMLCJC-UHFFFAOYSA-N 0.000 claims 1
SEOIDFIIPDNWLM-UHFFFAOYSA-N 2-[[4-(2-piperidin-1-ylethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound C1CCCCN1CCN(C(=NN=1)C=2SC=CC=2)C=1SCC1=CC=CC=N1 SEOIDFIIPDNWLM-UHFFFAOYSA-N 0.000 claims 1
BHBVWXZUGWVDSZ-UHFFFAOYSA-N 2-[[4-(3-methoxypropyl)-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C2N(CCCC2)C)N(CCCOC)C=1SCC1=CC=CC=C1C#N BHBVWXZUGWVDSZ-UHFFFAOYSA-N 0.000 claims 1
FRYXCPMUQMCSLY-UHFFFAOYSA-N 2-[[4-(3-methoxypropyl)-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound N=1N=C(C2N(CCCC2)C)N(CCCOC)C=1SCC1=CC=CC=N1 FRYXCPMUQMCSLY-UHFFFAOYSA-N 0.000 claims 1
ARDDRMJDJCSFCJ-UHFFFAOYSA-N 2-[[4-(3-methoxypropyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2SC=CC=2)N(CCCOC)C=1SCC1=CC=CC=C1C#N ARDDRMJDJCSFCJ-UHFFFAOYSA-N 0.000 claims 1
ZOWIZVSYPKGAES-UHFFFAOYSA-N 2-[[4-(3-methoxypropyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound N=1N=C(C=2SC=CC=2)N(CCCOC)C=1SCC1=CC=CC=N1 ZOWIZVSYPKGAES-UHFFFAOYSA-N 0.000 claims 1
CLRVYXYMZPMEBK-UHFFFAOYSA-N 2-[[4-(cyclopropylmethyl)-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound CN1CCCCC1C(N1CC2CC2)=NN=C1SCC1=CC=CC=C1C#N CLRVYXYMZPMEBK-UHFFFAOYSA-N 0.000 claims 1
YRINOYIGKLXCIQ-UHFFFAOYSA-N 2-[[4-(cyclopropylmethyl)-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound CN1CCCCC1C(N1CC2CC2)=NN=C1SCC1=CC=CC=N1 YRINOYIGKLXCIQ-UHFFFAOYSA-N 0.000 claims 1
WXAKQJHUQMFPOS-UHFFFAOYSA-N 2-[[4-(cyclopropylmethyl)-5-(2-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound OC1=CC=CC=C1C(N1CC2CC2)=NN=C1SCC1=CC=CC=C1C#N WXAKQJHUQMFPOS-UHFFFAOYSA-N 0.000 claims 1
CBRGHNAWNYBXGL-UHFFFAOYSA-N 2-[[4-(cyclopropylmethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound COC1=CC=CC=C1C(N1CC2CC2)=NN=C1SCC1=CC=CC=C1C#N CBRGHNAWNYBXGL-UHFFFAOYSA-N 0.000 claims 1
IGCVQHXVMZYPPW-UHFFFAOYSA-N 2-[[4-(cyclopropylmethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound COC1=CC=CC=C1C(N1CC2CC2)=NN=C1SCC1=CC=CC=N1 IGCVQHXVMZYPPW-UHFFFAOYSA-N 0.000 claims 1
MVVFAXDEAJJUHX-UHFFFAOYSA-N 2-[[4-(cyclopropylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N#CC1=CC=CC=C1CSC(N1CC2CC2)=NN=C1C1=CC=CS1 MVVFAXDEAJJUHX-UHFFFAOYSA-N 0.000 claims 1
XUZQLPIUBVOSPF-UHFFFAOYSA-N 2-[[4-(cyclopropylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound C=1C=CC=NC=1CSC(N1CC2CC2)=NN=C1C1=CC=CS1 XUZQLPIUBVOSPF-UHFFFAOYSA-N 0.000 claims 1
CULJGGGZAVWCJQ-UHFFFAOYSA-N 2-[[4-(furan-2-ylmethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(2-methyl-4-nitrophenyl)acetamide Chemical compound COC1=CC=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1C CULJGGGZAVWCJQ-UHFFFAOYSA-N 0.000 claims 1
OWVXXMRCVHEFAL-UHFFFAOYSA-N 2-[[4-(furan-2-ylmethyl)-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1CC=2OC=CC=2)=NN=C1C1=CC=C(O)C=C1 OWVXXMRCVHEFAL-UHFFFAOYSA-N 0.000 claims 1
ZRRREFSGKKDUIZ-UHFFFAOYSA-N 2-[[4-(furan-2-ylmethyl)-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-3-nitrophenyl)acetamide Chemical compound C1=C([N+]([O-])=O)C(C)=CC=C1NC(=O)CSC(N1CC=2OC=CC=2)=NN=C1C1=CC=C(O)C=C1 ZRRREFSGKKDUIZ-UHFFFAOYSA-N 0.000 claims 1
SNPVLGUNUSTUJR-UHFFFAOYSA-N 2-[[4-(furan-2-ylmethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone Chemical compound [O-][N+](=O)C1=CC=CC(C(=O)CSC=2N(C(C=3C=CN=CC=3)=NN=2)CC=2OC=CC=2)=C1 SNPVLGUNUSTUJR-UHFFFAOYSA-N 0.000 claims 1
KHDNGFFVKWKKMO-UHFFFAOYSA-N 2-[[4-benzyl-5-(2-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-piperidin-1-ylethanone Chemical compound OC1=CC=CC=C1C(N1CC=2C=CC=CC=2)=NN=C1SCC(=O)N1CCCCC1 KHDNGFFVKWKKMO-UHFFFAOYSA-N 0.000 claims 1
HKLYIBRCYMOGRE-UHFFFAOYSA-N 2-[[4-benzyl-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methyl-4-nitrophenyl)acetamide Chemical compound CC1=CC([N+]([O-])=O)=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=C(O)C=C1 HKLYIBRCYMOGRE-UHFFFAOYSA-N 0.000 claims 1
PFSOJXWTRNCUEB-UHFFFAOYSA-N 2-[[4-cyclopropyl-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound CN1CCCCC1C(N1C2CC2)=NN=C1SCC1=CC=CC=C1C#N PFSOJXWTRNCUEB-UHFFFAOYSA-N 0.000 claims 1
FMVGOYIDPMFOFC-UHFFFAOYSA-N 2-[[4-cyclopropyl-5-(1-methylpiperidin-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound CN1CCCCC1C(N1C2CC2)=NN=C1SCC1=CC=CC=N1 FMVGOYIDPMFOFC-UHFFFAOYSA-N 0.000 claims 1
DJOUEYIDNQKSRC-UHFFFAOYSA-N 2-[[4-cyclopropyl-5-(2-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound OC1=CC=CC=C1C(N1C2CC2)=NN=C1SCC1=CC=CC=C1C#N DJOUEYIDNQKSRC-UHFFFAOYSA-N 0.000 claims 1
LINFGWOFLALQRP-UHFFFAOYSA-N 2-[[4-cyclopropyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound COC1=CC=CC=C1C(N1C2CC2)=NN=C1SCC1=CC=CC=C1C#N LINFGWOFLALQRP-UHFFFAOYSA-N 0.000 claims 1
CTDSFRRXCMMZOY-UHFFFAOYSA-N 2-[[4-cyclopropyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound COC1=CC=CC=C1C(N1C2CC2)=NN=C1SCC1=CC=CC=N1 CTDSFRRXCMMZOY-UHFFFAOYSA-N 0.000 claims 1
VZTCHSNKIJYKPH-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)C1=CC=C(OC)C=C1 VZTCHSNKIJYKPH-UHFFFAOYSA-N 0.000 claims 1
HMVPXJQFPDMWAX-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(2-ethylphenyl)acetamide Chemical compound CCC1=CC=CC=C1NC(=O)CSC(N1CC)=NN=C1C1=CC=CC=C1OC HMVPXJQFPDMWAX-UHFFFAOYSA-N 0.000 claims 1
NXOBQDGGXWNEJX-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methoxyphenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=C(OC)C=C1 NXOBQDGGXWNEJX-UHFFFAOYSA-N 0.000 claims 1
AYEMNPXYQMUAFQ-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methyl-3-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=C(C)C([N+]([O-])=O)=C1 AYEMNPXYQMUAFQ-UHFFFAOYSA-N 0.000 claims 1
JJIGHLSEXQBPSV-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(4-phenyl-1,3-thiazol-2-yl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC(SC=1)=NC=1C1=CC=CC=C1 JJIGHLSEXQBPSV-UHFFFAOYSA-N 0.000 claims 1
KIFDCBRPKGGOJK-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-[3-(trifluoromethyl)phenyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=CC(C(F)(F)F)=C1 KIFDCBRPKGGOJK-UHFFFAOYSA-N 0.000 claims 1
UMRKHJPJJDFGCY-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-naphthalen-1-ylpropanamide Chemical compound CCN1C(SC(C)C(=O)NC=2C3=CC=CC=C3C=CC=2)=NN=C1C1=CC=CC=C1OC UMRKHJPJJDFGCY-UHFFFAOYSA-N 0.000 claims 1
IBTCHHIFBKNKJA-UHFFFAOYSA-N 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-phenylpropanamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SC(C)C(=O)NC1=CC=CC=C1 IBTCHHIFBKNKJA-UHFFFAOYSA-N 0.000 claims 1
BIXRBEZLDNXWOT-UHFFFAOYSA-N 2-[[4-ethyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=C(C)C=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1[N+]([O-])=O BIXRBEZLDNXWOT-UHFFFAOYSA-N 0.000 claims 1
UCNCULCBBKCGMT-UHFFFAOYSA-N 2-[[4-ethyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methyl-3-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=C(C)C=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(C)C([N+]([O-])=O)=C1 UCNCULCBBKCGMT-UHFFFAOYSA-N 0.000 claims 1
YISAVIXLONXTQF-UHFFFAOYSA-N 2-[[4-ethyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(4-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=C(C)C=CC=2)N(CC)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1 YISAVIXLONXTQF-UHFFFAOYSA-N 0.000 claims 1
STPWYMYFAYTODS-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-iodo-2-methylphenyl)acetamide Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(I)C=C1C STPWYMYFAYTODS-UHFFFAOYSA-N 0.000 claims 1
BAAQDXXMTDREET-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-3-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(C)C([N+]([O-])=O)=C1 BAAQDXXMTDREET-UHFFFAOYSA-N 0.000 claims 1
RMLDXALGQLGABQ-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-phenylacetamide Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1 RMLDXALGQLGABQ-UHFFFAOYSA-N 0.000 claims 1
AJJSJOIPTPXSKS-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC(=O)C1=CC=C(OC)C=C1 AJJSJOIPTPXSKS-UHFFFAOYSA-N 0.000 claims 1
AHFDVHVFKYXPAQ-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC(=O)C1=CC=CC=C1 AHFDVHVFKYXPAQ-UHFFFAOYSA-N 0.000 claims 1
XZMCFSBRDJVADM-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methyl-3-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(C)C([N+]([O-])=O)=C1 XZMCFSBRDJVADM-UHFFFAOYSA-N 0.000 claims 1
LVJKBTGFSKQXEC-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-morpholin-4-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound N=1N=C(C=2C=CC(=CC=2)S(=O)(=O)N2CCOCC2)N(CC)C=1SCC(=O)C1=CC=C(C)C=C1 LVJKBTGFSKQXEC-UHFFFAOYSA-N 0.000 claims 1
JYQRIXGZWNUCEU-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound N=1N=C(C=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1SCC(=O)C1=CC=C(C)C=C1 JYQRIXGZWNUCEU-UHFFFAOYSA-N 0.000 claims 1
ZCDCZLGTVJACCG-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1SCC(=O)C1=CC=CC=C1 ZCDCZLGTVJACCG-UHFFFAOYSA-N 0.000 claims 1
LBISGMQVGFAQIA-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-piperidin-1-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound N=1N=C(C=2C=CC(=CC=2)S(=O)(=O)N2CCCCC2)N(CC)C=1SCC(=O)C1=CC=C(C)C=C1 LBISGMQVGFAQIA-UHFFFAOYSA-N 0.000 claims 1
UCXFFQAVKRUEMF-UHFFFAOYSA-N 2-[[4-ethyl-5-(4-piperidin-1-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2C=CC(=CC=2)S(=O)(=O)N2CCCCC2)N(CC)C=1SCC(=O)C1=CC=CC=C1 UCXFFQAVKRUEMF-UHFFFAOYSA-N 0.000 claims 1
DPEYTPARTGASAS-UHFFFAOYSA-N 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(C=2OC=CC=2)N(CC)C=1SCC(=O)C1=CC=C(OC)C=C1 DPEYTPARTGASAS-UHFFFAOYSA-N 0.000 claims 1
BOTYZJBEPAFRIX-UHFFFAOYSA-N 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylsulfonylphenyl)ethanone Chemical compound N=1N=C(C=2OC=CC=2)N(CC)C=1SCC(=O)C1=CC=C(S(C)(=O)=O)C=C1 BOTYZJBEPAFRIX-UHFFFAOYSA-N 0.000 claims 1
LKXBQKNOOWEDNS-UHFFFAOYSA-N 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2OC=CC=2)N(CC)C=1SCC(=O)C1=CC=CC=C1 LKXBQKNOOWEDNS-UHFFFAOYSA-N 0.000 claims 1
SAIJZRFYDGDCSD-UHFFFAOYSA-N 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-pyridin-3-ylethanone Chemical compound N=1N=C(C=2OC=CC=2)N(CC)C=1SCC(=O)C1=CC=CN=C1 SAIJZRFYDGDCSD-UHFFFAOYSA-N 0.000 claims 1
LYUNDGAQTWGJPJ-UHFFFAOYSA-N 2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC(OC)=CC=2)N(CC)C=1CNC1=CC=C(F)C=C1 LYUNDGAQTWGJPJ-UHFFFAOYSA-N 0.000 claims 1
OQFFSYICUZUMCL-UHFFFAOYSA-N 2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC(C)=CC=2)N(CC)C=1CNC1=CC=C(F)C=C1 OQFFSYICUZUMCL-UHFFFAOYSA-N 0.000 claims 1
CCFSLFQZFBBCII-UHFFFAOYSA-N 2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methyl-3-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=C(C(C)=CC=2)[N+]([O-])=O)N(CC)C=1CNC1=CC=C(F)C=C1 CCFSLFQZFBBCII-UHFFFAOYSA-N 0.000 claims 1
YAETXVAHBRVUIL-UHFFFAOYSA-N 2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]-n-(4-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1CNC1=CC=C(F)C=C1 YAETXVAHBRVUIL-UHFFFAOYSA-N 0.000 claims 1
QZNKZVWHTCFSKQ-UHFFFAOYSA-N 2-[[4-ethyl-5-[(4-methoxyphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC=CC=2)N(CC)C=1COC1=CC=C(OC)C=C1 QZNKZVWHTCFSKQ-UHFFFAOYSA-N 0.000 claims 1
NHUJAPJTCQCLIT-UHFFFAOYSA-N 2-[[4-ethyl-5-[(4-methylanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC(C)=CC=2)N(CC)C=1CNC1=CC=C(C)C=C1 NHUJAPJTCQCLIT-UHFFFAOYSA-N 0.000 claims 1
QBDRVKMIADPSEQ-UHFFFAOYSA-N 2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound C1=CC(C)=CC=C1C(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C QBDRVKMIADPSEQ-UHFFFAOYSA-N 0.000 claims 1
KFXZEIZHYRGORN-UHFFFAOYSA-N 2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-(3-nitrophenyl)acetamide Chemical compound CC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=CC([N+]([O-])=O)=C1 KFXZEIZHYRGORN-UHFFFAOYSA-N 0.000 claims 1
FLOSBIFEPPSMEE-UHFFFAOYSA-N 2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-n-[2-(trifluoromethyl)phenyl]acetamide Chemical compound CC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=CC=C1C(F)(F)F FLOSBIFEPPSMEE-UHFFFAOYSA-N 0.000 claims 1
PWIVEAIROVLHMI-UHFFFAOYSA-N 2-[[4-methyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2C=CC(=CC=2)[N+]([O-])=O)N(C)C=1SCC(=O)C1=CC=CC=C1 PWIVEAIROVLHMI-UHFFFAOYSA-N 0.000 claims 1
FAPYTVIYSGHDBU-UHFFFAOYSA-N 2-[[5-(1-methylpiperidin-2-yl)-4-(2-piperidin-1-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound CN1CCCCC1C(N1CCN2CCCCC2)=NN=C1SCC1=CC=CC=C1C#N FAPYTVIYSGHDBU-UHFFFAOYSA-N 0.000 claims 1
CKQBSTHOLHFTKJ-UHFFFAOYSA-N 2-[[5-(1-methylpiperidin-2-yl)-4-(2-piperidin-1-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound CN1CCCCC1C(N1CCN2CCCCC2)=NN=C1SCC1=CC=CC=N1 CKQBSTHOLHFTKJ-UHFFFAOYSA-N 0.000 claims 1
UFRYQARCQHOJLS-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2-methoxy-4-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1OC UFRYQARCQHOJLS-UHFFFAOYSA-N 0.000 claims 1
YLOGFAIKAQLCEA-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2-methyl-4-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1C YLOGFAIKAQLCEA-UHFFFAOYSA-N 0.000 claims 1
HCDMEXKOPHYLNO-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(3-chlorophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=CC(Cl)=C1 HCDMEXKOPHYLNO-UHFFFAOYSA-N 0.000 claims 1
ZZQKBTYPCCITHB-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(3-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=CC([N+]([O-])=O)=C1 ZZQKBTYPCCITHB-UHFFFAOYSA-N 0.000 claims 1
WEHASPBBTYKREO-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-ethoxyphenyl)acetamide Chemical compound C1=CC(OCC)=CC=C1NC(=O)CSC(N1CC)=NN=C1C1=CC=CC=C1Br WEHASPBBTYKREO-UHFFFAOYSA-N 0.000 claims 1
KYARKZMKUBRZMC-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-fluorophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=C(F)C=C1 KYARKZMKUBRZMC-UHFFFAOYSA-N 0.000 claims 1
WXKUZPSDZFKOSP-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(5-methyl-1,3-thiazol-2-yl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=NC=C(C)S1 WXKUZPSDZFKOSP-UHFFFAOYSA-N 0.000 claims 1
TWTIXIDLPLIJOX-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-phenylacetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=CC=C1 TWTIXIDLPLIJOX-UHFFFAOYSA-N 0.000 claims 1
SVZLQVRIQHMLHT-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br SVZLQVRIQHMLHT-UHFFFAOYSA-N 0.000 claims 1
JBQPADXCFAJCGV-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound C1=CC(C)=CC=C1C(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br JBQPADXCFAJCGV-UHFFFAOYSA-N 0.000 claims 1
FETKFZVWCWAKQR-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(C)C=1SCC(=O)C1=CC=CC=C1 FETKFZVWCWAKQR-UHFFFAOYSA-N 0.000 claims 1
HELJGTBPSSPFOR-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2,4-dimethylphenyl)acetamide Chemical compound CC1=CC(C)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br HELJGTBPSSPFOR-UHFFFAOYSA-N 0.000 claims 1
SABJRBIXAFOGEO-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2-methoxy-4-nitrophenyl)acetamide Chemical compound COC1=CC([N+]([O-])=O)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br SABJRBIXAFOGEO-UHFFFAOYSA-N 0.000 claims 1
WAQZRXHCAAWDCA-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2-methyl-4-nitrophenyl)acetamide Chemical compound CC1=CC([N+]([O-])=O)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br WAQZRXHCAAWDCA-UHFFFAOYSA-N 0.000 claims 1
BRXDYKZYNOWVMK-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(C)C=1SCC(=O)NC1=CC=CC=C1[N+]([O-])=O BRXDYKZYNOWVMK-UHFFFAOYSA-N 0.000 claims 1
GATPLZCGJPIMHP-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(3,4-dimethylphenyl)acetamide Chemical compound C1=C(C)C(C)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br GATPLZCGJPIMHP-UHFFFAOYSA-N 0.000 claims 1
PGSKPNBHMBZIKJ-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-chlorophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(C)C=1SCC(=O)NC1=CC=C(Cl)C=C1 PGSKPNBHMBZIKJ-UHFFFAOYSA-N 0.000 claims 1
QRIGJSWJABHUHD-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-ethoxyphenyl)acetamide Chemical compound C1=CC(OCC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br QRIGJSWJABHUHD-UHFFFAOYSA-N 0.000 claims 1
LWQCJALZMRSYMG-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-fluorophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(C)C=1SCC(=O)NC1=CC=C(F)C=C1 LWQCJALZMRSYMG-UHFFFAOYSA-N 0.000 claims 1
WKYBKAUYZQWGLB-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methoxy-2-nitrophenyl)acetamide Chemical compound [O-][N+](=O)C1=CC(OC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br WKYBKAUYZQWGLB-UHFFFAOYSA-N 0.000 claims 1
GUSIXBSKJSZOEB-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br GUSIXBSKJSZOEB-UHFFFAOYSA-N 0.000 claims 1
FAZNPJNSPSJNJH-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-methyl-3-nitrophenyl)acetamide Chemical compound C1=C([N+]([O-])=O)C(C)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br FAZNPJNSPSJNJH-UHFFFAOYSA-N 0.000 claims 1
GELQXPCHVGBPDW-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(C)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1 GELQXPCHVGBPDW-UHFFFAOYSA-N 0.000 claims 1
GWZIEMOFXWUWDO-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-phenyl-1,3-thiazol-2-yl)acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(C)C=1SCC(=O)NC(SC=1)=NC=1C1=CC=CC=C1 GWZIEMOFXWUWDO-UHFFFAOYSA-N 0.000 claims 1
URABVVBXBUHRMV-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-phenylacetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(C)C=1SCC(=O)NC1=CC=CC=C1 URABVVBXBUHRMV-UHFFFAOYSA-N 0.000 claims 1
OYVBBUOUCSKWQB-UHFFFAOYSA-N 2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetonitrile Chemical compound CN1C(SCC#N)=NN=C1C1=CC=CC=C1Br OYVBBUOUCSKWQB-UHFFFAOYSA-N 0.000 claims 1
FWKVKKVZGJOLHV-UHFFFAOYSA-N 2-[[5-(2-hydroxyphenyl)-4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CCOC)C=1SCC1=CC=CC=C1C#N FWKVKKVZGJOLHV-UHFFFAOYSA-N 0.000 claims 1
GMJDPTJZRVGAOJ-UHFFFAOYSA-N 2-[[5-(2-hydroxyphenyl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-piperidin-1-ylethanone Chemical compound OC1=CC=CC=C1C(N1CCC=2C=CC=CC=2)=NN=C1SCC(=O)N1CCCCC1 GMJDPTJZRVGAOJ-UHFFFAOYSA-N 0.000 claims 1
CIXKSOJTDAAFRS-UHFFFAOYSA-N 2-[[5-(2-hydroxyphenyl)-4-(2-piperidin-1-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound OC1=CC=CC=C1C(N1CCN2CCCCC2)=NN=C1SCC1=CC=CC=C1C#N CIXKSOJTDAAFRS-UHFFFAOYSA-N 0.000 claims 1
IAYFZMGEAYMGHC-UHFFFAOYSA-N 2-[[5-(2-hydroxyphenyl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CCCOC)C=1SCC1=CC=CC=C1C#N IAYFZMGEAYMGHC-UHFFFAOYSA-N 0.000 claims 1
UXSZJHIIHHDUSB-UHFFFAOYSA-N 2-[[5-(2-methoxyphenyl)-4-(2-piperidin-1-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound COC1=CC=CC=C1C(N1CCN2CCCCC2)=NN=C1SCC1=CC=CC=C1C#N UXSZJHIIHHDUSB-UHFFFAOYSA-N 0.000 claims 1
CGLFOHHBGQZPDV-UHFFFAOYSA-N 2-[[5-(2-methoxyphenyl)-4-(2-piperidin-1-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound COC1=CC=CC=C1C(N1CCN2CCCCC2)=NN=C1SCC1=CC=CC=N1 CGLFOHHBGQZPDV-UHFFFAOYSA-N 0.000 claims 1
PEQZAKUKKNVNBD-UHFFFAOYSA-N 2-[[5-(2-methoxyphenyl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CCCOC)C=1SCC1=CC=CC=C1C#N PEQZAKUKKNVNBD-UHFFFAOYSA-N 0.000 claims 1
OJNMVRPPGJZYPO-UHFFFAOYSA-N 2-[[5-(2-methoxyphenyl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CCCOC)C=1SCC1=CC=CC=N1 OJNMVRPPGJZYPO-UHFFFAOYSA-N 0.000 claims 1
SHJNHIBXDMEPLY-UHFFFAOYSA-N 2-[[5-(2-methoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-n-(4-phenyl-1,3-thiazol-2-yl)acetamide Chemical compound COC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=NC(C=2C=CC=CC=2)=CS1 SHJNHIBXDMEPLY-UHFFFAOYSA-N 0.000 claims 1
OGSLKFCZCQXWPQ-UHFFFAOYSA-N 2-[[5-(3,4-dimethoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound C1=C(OC)C(OC)=CC=C1C(N1C)=NN=C1SCC(=O)C1=CC=C(C)C=C1 OGSLKFCZCQXWPQ-UHFFFAOYSA-N 0.000 claims 1
NAJXTAVJEPPUBU-UHFFFAOYSA-N 2-[[5-(4-chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1[N+]([O-])=O NAJXTAVJEPPUBU-UHFFFAOYSA-N 0.000 claims 1
NOUPHDRPAZGLTI-UHFFFAOYSA-N 2-[[5-(4-hydroxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-nitrophenyl)acetamide Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(C)C=1SCC(=O)NC1=CC=C([N+]([O-])=O)C=C1 NOUPHDRPAZGLTI-UHFFFAOYSA-N 0.000 claims 1
AMTKHCPUJZKRGO-UHFFFAOYSA-N 2-[[5-(4-hydroxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-phenyl-1,3-thiazol-2-yl)acetamide Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(C)C=1SCC(=O)NC(SC=1)=NC=1C1=CC=CC=C1 AMTKHCPUJZKRGO-UHFFFAOYSA-N 0.000 claims 1
NYQWFYGDQFLCAP-UHFFFAOYSA-N 2-[[5-(4-methoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound C1=CC(OC)=CC=C1C(N1C)=NN=C1SCC(=O)C1=CC=CC=C1 NYQWFYGDQFLCAP-UHFFFAOYSA-N 0.000 claims 1
OPFXBHWKOCLSKY-UHFFFAOYSA-N 2-[[5-(furan-2-yl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound C1=CC(OC)=CC=C1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CO1 OPFXBHWKOCLSKY-UHFFFAOYSA-N 0.000 claims 1
XTYOJFSKTHKIEI-UHFFFAOYSA-N 2-[[5-(furan-2-yl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylsulfonylphenyl)ethanone Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CO1 XTYOJFSKTHKIEI-UHFFFAOYSA-N 0.000 claims 1
CXJQKXSQGVQKGW-UHFFFAOYSA-N 2-[[5-(furan-2-yl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound C=1C=CC=CC=1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CO1 CXJQKXSQGVQKGW-UHFFFAOYSA-N 0.000 claims 1
ZYWKLTOIYSZYEN-UHFFFAOYSA-N 2-[[5-(furan-2-yl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-pyridin-3-ylethanone Chemical compound C=1C=CN=CC=1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CO1 ZYWKLTOIYSZYEN-UHFFFAOYSA-N 0.000 claims 1
ZWRVAIVKHFVXLJ-UHFFFAOYSA-N 2-[[5-[(2,4-dimethylanilino)methyl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound CC1=CC(C)=CC=C1NCC(N1CC=2OC=CC=2)=NN=C1SCC(=O)C1=CC=CC=C1 ZWRVAIVKHFVXLJ-UHFFFAOYSA-N 0.000 claims 1
QHYXIAHWDAHWPW-UHFFFAOYSA-N 2-[[5-[(2,4-dimethylanilino)methyl]-4-(oxolan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound C1=CC(C)=CC=C1C(=O)CSC(N1CC2OCCC2)=NN=C1CNC1=CC=C(C)C=C1C QHYXIAHWDAHWPW-UHFFFAOYSA-N 0.000 claims 1
WPRUYJYBJUPTHW-UHFFFAOYSA-N 2-[[5-[(2,4-dimethylanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC(OC)=CC=2)N(CC)C=1CNC1=CC=C(C)C=C1C WPRUYJYBJUPTHW-UHFFFAOYSA-N 0.000 claims 1
IRJDZKVQPLBCAH-UHFFFAOYSA-N 2-[[5-[(2,4-dimethylanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC(C)=CC=2)N(CC)C=1CNC1=CC=C(C)C=C1C IRJDZKVQPLBCAH-UHFFFAOYSA-N 0.000 claims 1
OYQWGMUQQMULAY-UHFFFAOYSA-N 2-[[5-[(2,6-dimethylanilino)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound CC1=CC=CC(C)=C1NCC(N1C)=NN=C1SCC(=O)C1=CC=CC=C1 OYQWGMUQQMULAY-UHFFFAOYSA-N 0.000 claims 1
QTJULHBXGMEAFM-UHFFFAOYSA-N 2-[[5-[(2-chloroanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-chlorophenyl)ethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC(Cl)=CC=2)N(CC)C=1CNC1=CC=CC=C1Cl QTJULHBXGMEAFM-UHFFFAOYSA-N 0.000 claims 1
JTTPJDWITVUZEN-UHFFFAOYSA-N 2-[[5-[(2-chloroanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-piperidin-1-ylethanone Chemical compound N=1N=C(SCC(=O)N2CCCCC2)N(CC)C=1CNC1=CC=CC=C1Cl JTTPJDWITVUZEN-UHFFFAOYSA-N 0.000 claims 1
ZJLYVQFVBUOBID-UHFFFAOYSA-N 2-[[5-[(3-chloroanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC=CC=2)N(CC)C=1CNC1=CC=CC(Cl)=C1 ZJLYVQFVBUOBID-UHFFFAOYSA-N 0.000 claims 1
BVMKIXYQLRDAJV-UHFFFAOYSA-N 2-[[5-[(4-chloroanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-n-(2-nitrophenyl)acetamide Chemical compound N=1N=C(SCC(=O)NC=2C(=CC=CC=2)[N+]([O-])=O)N(CC)C=1CNC1=CC=C(Cl)C=C1 BVMKIXYQLRDAJV-UHFFFAOYSA-N 0.000 claims 1
LYTPZVQQHMBXPY-UHFFFAOYSA-N 2-[[5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]-4h-1,4-benzothiazin-3-one Chemical compound CN1C(CC2C(NC3=CC=CC=C3S2)=O)=NN=C1SCC1=CC=C(Cl)C=C1 LYTPZVQQHMBXPY-UHFFFAOYSA-N 0.000 claims 1
MLMSYHUAHMVHCI-UHFFFAOYSA-N 2-[[5-[(4-fluoroanilino)methyl]-4-(oxolan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methylphenyl)ethanone Chemical compound C1=CC(C)=CC=C1C(=O)CSC(N1CC2OCCC2)=NN=C1CNC1=CC=C(F)C=C1 MLMSYHUAHMVHCI-UHFFFAOYSA-N 0.000 claims 1
LFLDRGOWTWLONP-UHFFFAOYSA-N 2-[[5-[(4-fluoroanilino)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound N=1N=C(SCC(=O)C=2C=CC=CC=2)N(C)C=1CNC1=CC=C(F)C=C1 LFLDRGOWTWLONP-UHFFFAOYSA-N 0.000 claims 1
FYUOVOZPWYCNEI-UHFFFAOYSA-N 2-[[5-[(4-methoxyphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone Chemical compound C1=CC(OC)=CC=C1OCC(N1C)=NN=C1SCC(=O)C1=CC=C(OC)C=C1 FYUOVOZPWYCNEI-UHFFFAOYSA-N 0.000 claims 1
IQMVOMLBQSAEMN-UHFFFAOYSA-N 2-[[5-[(4-methoxyphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone Chemical compound C1=CC(OC)=CC=C1OCC(N1C)=NN=C1SCC(=O)C1=CC=CC=C1 IQMVOMLBQSAEMN-UHFFFAOYSA-N 0.000 claims 1
MAAPPOOZMSSYGW-UHFFFAOYSA-N 2-[[5-methyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-n-[3-(trifluoromethyl)phenyl]acetamide Chemical compound C=1C=CC=CC=1CCN1C(C)=NN=C1SCC(=O)NC1=CC=CC(C(F)(F)F)=C1 MAAPPOOZMSSYGW-UHFFFAOYSA-N 0.000 claims 1
PMDUBZQXBMFHGE-UHFFFAOYSA-N 2-[[5-methyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-n-naphthalen-1-ylacetamide Chemical compound CC1=NN=C(SCC(=O)NC=2C3=CC=CC=C3C=CC=2)N1CCC1=CC=CC=C1 PMDUBZQXBMFHGE-UHFFFAOYSA-N 0.000 claims 1
OZWREHMIMBUIBW-UHFFFAOYSA-N 2-[[5-methyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-n-phenylacetamide Chemical compound C=1C=CC=CC=1CCN1C(C)=NN=C1SCC(=O)NC1=CC=CC=C1 OZWREHMIMBUIBW-UHFFFAOYSA-N 0.000 claims 1
BVXDLQQFAPDQKW-UHFFFAOYSA-N 2-[[5-phenyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-pyridin-3-ylethanone Chemical compound C=1C=CN=CC=1C(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 BVXDLQQFAPDQKW-UHFFFAOYSA-N 0.000 claims 1
PDEAYYAQSYOTJP-UHFFFAOYSA-N 2-bromo-n-cyclohexyl-n-methylbenzamide Chemical compound C=1C=CC=C(Br)C=1C(=O)N(C)C1CCCCC1 PDEAYYAQSYOTJP-UHFFFAOYSA-N 0.000 claims 1
SOFJAWFTYRLZBI-UHFFFAOYSA-N 2-chloro-n-cyclohexyl-6-fluoro-n-methylbenzamide Chemical compound FC=1C=CC=C(Cl)C=1C(=O)N(C)C1CCCCC1 SOFJAWFTYRLZBI-UHFFFAOYSA-N 0.000 claims 1
ZIMRYTSHKDYHEH-UHFFFAOYSA-N 2-chloro-n-cyclohexyl-n-ethyl-4-nitrobenzamide Chemical compound C=1C=C([N+]([O-])=O)C=C(Cl)C=1C(=O)N(CC)C1CCCCC1 ZIMRYTSHKDYHEH-UHFFFAOYSA-N 0.000 claims 1
AOTSIGYCJVFJSK-UHFFFAOYSA-N 3,5-dichloro-n-cyclohexyl-n-methylbenzamide Chemical compound C=1C(Cl)=CC(Cl)=CC=1C(=O)N(C)C1CCCCC1 AOTSIGYCJVFJSK-UHFFFAOYSA-N 0.000 claims 1
SQUUWDKKCXOUFN-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O SQUUWDKKCXOUFN-UHFFFAOYSA-N 0.000 claims 1
APYSFURDEKPNPG-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 APYSFURDEKPNPG-UHFFFAOYSA-N 0.000 claims 1
SWPSVWPGUSAAQP-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 SWPSVWPGUSAAQP-UHFFFAOYSA-N 0.000 claims 1
XAKXVZZICHTUGW-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 XAKXVZZICHTUGW-UHFFFAOYSA-N 0.000 claims 1
VACLYSBTPLBLMK-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O VACLYSBTPLBLMK-UHFFFAOYSA-N 0.000 claims 1
JKKYVKCAZRJCRX-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 JKKYVKCAZRJCRX-UHFFFAOYSA-N 0.000 claims 1
VDPYERUAJIQQRJ-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-5-(cyclohexylmethylsulfanyl)-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1CCCCC1 VDPYERUAJIQQRJ-UHFFFAOYSA-N 0.000 claims 1
BKRAEGKYBYPRRF-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl BKRAEGKYBYPRRF-UHFFFAOYSA-N 0.000 claims 1
RHPXENSHHDVUSA-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl RHPXENSHHDVUSA-UHFFFAOYSA-N 0.000 claims 1
ALUDBMDJTAIHFW-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-5-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=CC=C1Cl ALUDBMDJTAIHFW-UHFFFAOYSA-N 0.000 claims 1
IPONEIAWWGEKND-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 IPONEIAWWGEKND-UHFFFAOYSA-N 0.000 claims 1
IIAIJBPOOLHYLV-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-5-[(4-bromophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 IIAIJBPOOLHYLV-UHFFFAOYSA-N 0.000 claims 1
JUNRCDSERGLGRF-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound C1=C2OCOC2=CC(C2=NN=C(SCC=3C(=CC=4OCOC=4C=3)Cl)N2CC)=C1 JUNRCDSERGLGRF-UHFFFAOYSA-N 0.000 claims 1
FDHALABOVMMWHS-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O FDHALABOVMMWHS-UHFFFAOYSA-N 0.000 claims 1
QSZRMSSHWVTXMK-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 QSZRMSSHWVTXMK-UHFFFAOYSA-N 0.000 claims 1
MMOJEUZXXNJMSE-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=C(OC)C=C1 MMOJEUZXXNJMSE-UHFFFAOYSA-N 0.000 claims 1
QZFFKLBSOVYAFA-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 QZFFKLBSOVYAFA-UHFFFAOYSA-N 0.000 claims 1
ICWYPJGIOFEUFW-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 ICWYPJGIOFEUFW-UHFFFAOYSA-N 0.000 claims 1
FOIPLQZASNTOMD-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 FOIPLQZASNTOMD-UHFFFAOYSA-N 0.000 claims 1
CTULBSGKGGOXEI-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-5-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=CC=C1Cl CTULBSGKGGOXEI-UHFFFAOYSA-N 0.000 claims 1
LZWGTGSDCKNULB-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-5-[(4-bromophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=C(Br)C=C1 LZWGTGSDCKNULB-UHFFFAOYSA-N 0.000 claims 1
QWOZYRJMINCFCO-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound C1=CC=C2SC(C3=NN=C(SCC=4C(=CC=5OCOC=5C=4)Cl)N3CC)=CC2=C1 QWOZYRJMINCFCO-UHFFFAOYSA-N 0.000 claims 1
LLUHQFWZRQUSJD-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-4-(2-methylprop-2-enyl)-1h-1,2,4-triazole-5-thione Chemical compound N1C(=S)N(CC(=C)C)C(C=2C(=CC(Cl)=CC=2)Cl)=N1 LLUHQFWZRQUSJD-UHFFFAOYSA-N 0.000 claims 1
CHVNFDHQTPIKSU-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-4-(furan-2-ylmethyl)-5-methylsulfanyl-1,2,4-triazole Chemical compound C=1C=COC=1CN1C(SC)=NN=C1C1=CC=C(Cl)C=C1Cl CHVNFDHQTPIKSU-UHFFFAOYSA-N 0.000 claims 1
JMUBCVRQTQJXDS-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-4-prop-2-enyl-1h-1,2,4-triazole-5-thione Chemical compound ClC1=CC(Cl)=CC=C1C1=NNC(=S)N1CC=C JMUBCVRQTQJXDS-UHFFFAOYSA-N 0.000 claims 1
NJQBEFPUXBYGQT-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-5,5-dimethyl-6h-[1,2,4]triazolo[3,4-a]isoquinoline Chemical compound N12C(C)(C)CC3=CC=CC=C3C2=NN=C1C1=CC=C(Cl)C=C1Cl NJQBEFPUXBYGQT-UHFFFAOYSA-N 0.000 claims 1
FTQFYENWBZENCJ-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6,6-dimethyl-5,7-dihydro-1h-[1,2,4]triazolo[4,3-a]pyrimidine Chemical compound N12CC(C)(C)CNC2=NN=C1C1=CC=C(Cl)C=C1Cl FTQFYENWBZENCJ-UHFFFAOYSA-N 0.000 claims 1
NGKOMQXOGMMMDI-UHFFFAOYSA-N 3-(2-bromophenyl)-4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 NGKOMQXOGMMMDI-UHFFFAOYSA-N 0.000 claims 1
DUGZVFHBSSQHDR-UHFFFAOYSA-N 3-(2-bromophenyl)-4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=C(OC)C=C1 DUGZVFHBSSQHDR-UHFFFAOYSA-N 0.000 claims 1
GEZSCPVDYAUXGS-UHFFFAOYSA-N 3-(2-bromophenyl)-4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 GEZSCPVDYAUXGS-UHFFFAOYSA-N 0.000 claims 1
UBQQVQBPMGUXRO-UHFFFAOYSA-N 3-(2-bromophenyl)-4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O UBQQVQBPMGUXRO-UHFFFAOYSA-N 0.000 claims 1
NBHVEICNYXNJOF-UHFFFAOYSA-N 3-(2-bromophenyl)-4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 NBHVEICNYXNJOF-UHFFFAOYSA-N 0.000 claims 1
YEHRMYOEQVKBRI-UHFFFAOYSA-N 3-(2-bromophenyl)-4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 YEHRMYOEQVKBRI-UHFFFAOYSA-N 0.000 claims 1
VARJRQAJBOVJFZ-UHFFFAOYSA-N 3-(2-bromophenyl)-5-(cyclohexylmethylsulfanyl)-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1CCCCC1 VARJRQAJBOVJFZ-UHFFFAOYSA-N 0.000 claims 1
FHFRKPQUXFCTNG-UHFFFAOYSA-N 3-(2-bromophenyl)-5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl FHFRKPQUXFCTNG-UHFFFAOYSA-N 0.000 claims 1
JUJJGFAJRCMMPX-UHFFFAOYSA-N 3-(2-bromophenyl)-5-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=CC=C1Cl JUJJGFAJRCMMPX-UHFFFAOYSA-N 0.000 claims 1
WODFFZGITLJNLS-UHFFFAOYSA-N 3-(2-bromophenyl)-5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 WODFFZGITLJNLS-UHFFFAOYSA-N 0.000 claims 1
NCRIPJHEVGSKLF-UHFFFAOYSA-N 3-(2-bromophenyl)-5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 NCRIPJHEVGSKLF-UHFFFAOYSA-N 0.000 claims 1
WMLGOGGIJXEBLQ-UHFFFAOYSA-N 3-(2-bromophenyl)-5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=CC=C1Br WMLGOGGIJXEBLQ-UHFFFAOYSA-N 0.000 claims 1
QEDDHWCZOMHEJN-UHFFFAOYSA-N 3-(2-carbazol-9-ylethyl)-4-(2-methylprop-2-enyl)-1h-1,2,4-triazole-5-thione Chemical compound N1C(=S)N(CC(=C)C)C(CCN2C3=CC=CC=C3C3=CC=CC=C32)=N1 QEDDHWCZOMHEJN-UHFFFAOYSA-N 0.000 claims 1
SEGJYUDMAPFJDH-UHFFFAOYSA-N 3-(2-carbazol-9-ylethyl)-4-prop-2-enyl-1h-1,2,4-triazole-5-thione Chemical compound N1C(=S)N(CC=C)C(CCN2C3=CC=CC=C3C3=CC=CC=C32)=N1 SEGJYUDMAPFJDH-UHFFFAOYSA-N 0.000 claims 1
GWQHAEYSRALLID-UHFFFAOYSA-N 3-(2-chlorophenyl)-6,6-dimethyl-5,7-dihydro-1h-[1,2,4]triazolo[4,3-a]pyrimidine Chemical compound N12CC(C)(C)CNC2=NN=C1C1=CC=CC=C1Cl GWQHAEYSRALLID-UHFFFAOYSA-N 0.000 claims 1
GKWMIVQJQWDXQZ-UHFFFAOYSA-N 3-(2-chlorophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound ClC1=CC=CC=C1C1=NN=C2N1CCCCC2 GKWMIVQJQWDXQZ-UHFFFAOYSA-N 0.000 claims 1
WIDYZQDJTCZHEP-UHFFFAOYSA-N 3-(2-fluorophenyl)-4-methyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1CSC(N1C)=NN=C1C1=CC=CC=C1F WIDYZQDJTCZHEP-UHFFFAOYSA-N 0.000 claims 1
NVFDSULLRHMJQU-UHFFFAOYSA-N 3-(2-fluorophenyl)-5-(4-methoxyphenoxy)-[1,2,4]triazolo[4,3-c]quinazoline Chemical compound C1=CC(OC)=CC=C1OC(N12)=NC3=CC=CC=C3C2=NN=C1C1=CC=CC=C1F NVFDSULLRHMJQU-UHFFFAOYSA-N 0.000 claims 1
HIEGDBRJAYGLNK-UHFFFAOYSA-N 3-(2-fluorophenyl)-5-[(4-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)F)N(C)C=1SCC1=CC=C(F)C=C1 HIEGDBRJAYGLNK-UHFFFAOYSA-N 0.000 claims 1
DXLSNMWLJNIWCG-UHFFFAOYSA-N 3-(2-methoxyethylsulfanyl)-4-(3-methoxypropyl)-5-thiophen-2-yl-1,2,4-triazole Chemical compound COCCCN1C(SCCOC)=NN=C1C1=CC=CS1 DXLSNMWLJNIWCG-UHFFFAOYSA-N 0.000 claims 1
NBQVVFPOWJXAKT-UHFFFAOYSA-N 3-(2-methoxyethylsulfanyl)-5-(2-methoxyphenyl)-4-(3-methoxypropyl)-1,2,4-triazole Chemical compound COCCCN1C(SCCOC)=NN=C1C1=CC=CC=C1OC NBQVVFPOWJXAKT-UHFFFAOYSA-N 0.000 claims 1
AFRGNIDHOWKOTB-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound C1=C(Cl)C(Cl)=CC=C1C1=NN=C2N1CCCCC2 AFRGNIDHOWKOTB-UHFFFAOYSA-N 0.000 claims 1
NZYZRDCUROHPJS-UHFFFAOYSA-N 3-(3-bromophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound BrC1=CC=CC(C=2N3CCCCCC3=NN=2)=C1 NZYZRDCUROHPJS-UHFFFAOYSA-N 0.000 claims 1
DKSBFJYPICUHGY-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O DKSBFJYPICUHGY-UHFFFAOYSA-N 0.000 claims 1
KHOKJXYLHXIULU-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 KHOKJXYLHXIULU-UHFFFAOYSA-N 0.000 claims 1
OEAWYODXCQXBKI-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=C(C)C=C1 OEAWYODXCQXBKI-UHFFFAOYSA-N 0.000 claims 1
XXZQXUMKRCUIJL-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O XXZQXUMKRCUIJL-UHFFFAOYSA-N 0.000 claims 1
LVQHDRPKPCOZHW-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 LVQHDRPKPCOZHW-UHFFFAOYSA-N 0.000 claims 1
RGDYXWNGNRWOKY-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 RGDYXWNGNRWOKY-UHFFFAOYSA-N 0.000 claims 1
NHYZBLDZJVEMDA-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 NHYZBLDZJVEMDA-UHFFFAOYSA-N 0.000 claims 1
KNACMFWQZAPIJJ-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl KNACMFWQZAPIJJ-UHFFFAOYSA-N 0.000 claims 1
DXSYANUFWLNTRO-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-5-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=CC=C1Cl DXSYANUFWLNTRO-UHFFFAOYSA-N 0.000 claims 1
SFLBLJRLLAMZIO-UHFFFAOYSA-N 3-(3-chloro-4-methylthiophen-2-yl)-5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 SFLBLJRLLAMZIO-UHFFFAOYSA-N 0.000 claims 1
WPVJPFLNVCGFQS-UHFFFAOYSA-N 3-(3-chlorophenyl)-4-prop-2-enyl-1h-1,2,4-triazole-5-thione Chemical compound ClC1=CC=CC(C=2N(C(=S)NN=2)CC=C)=C1 WPVJPFLNVCGFQS-UHFFFAOYSA-N 0.000 claims 1
DYOWYUZNXBKQOK-UHFFFAOYSA-N 3-(3-chlorophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound ClC1=CC=CC(C=2N3CCCCCC3=NN=2)=C1 DYOWYUZNXBKQOK-UHFFFAOYSA-N 0.000 claims 1
PUBFRHXTIKNIPW-UHFFFAOYSA-N 3-(3-methyl-2-nitrophenyl)-4-(2-methylprop-2-enyl)-1h-1,2,4-triazole-5-thione Chemical compound N1C(=S)N(CC(=C)C)C(C=2C(=C(C)C=CC=2)[N+]([O-])=O)=N1 PUBFRHXTIKNIPW-UHFFFAOYSA-N 0.000 claims 1
AGGUEVUAPLNPMU-UHFFFAOYSA-N 3-(3-methylphenyl)-4-prop-2-enyl-1h-1,2,4-triazole-5-thione Chemical compound CC1=CC=CC(C=2N(C(=S)NN=2)CC=C)=C1 AGGUEVUAPLNPMU-UHFFFAOYSA-N 0.000 claims 1
AMYLUVBFQNSLRI-UHFFFAOYSA-N 3-(4-bromophenyl)-5,5-dimethyl-6h-[1,2,4]triazolo[3,4-a]isoquinoline Chemical compound N12C(C)(C)CC3=CC=CC=C3C2=NN=C1C1=CC=C(Br)C=C1 AMYLUVBFQNSLRI-UHFFFAOYSA-N 0.000 claims 1
ADECVMMOLHCQTO-UHFFFAOYSA-N 3-(4-bromophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound C1=CC(Br)=CC=C1C1=NN=C2N1CCCCC2 ADECVMMOLHCQTO-UHFFFAOYSA-N 0.000 claims 1
DRIRVGMWCBVYST-UHFFFAOYSA-N 3-(4-chlorophenyl)-4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 DRIRVGMWCBVYST-UHFFFAOYSA-N 0.000 claims 1
JLOLBXBPRLYBSL-UHFFFAOYSA-N 3-(4-chlorophenyl)-4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 JLOLBXBPRLYBSL-UHFFFAOYSA-N 0.000 claims 1
APYGBEMLYNUVCI-UHFFFAOYSA-N 3-(4-chlorophenyl)-4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 APYGBEMLYNUVCI-UHFFFAOYSA-N 0.000 claims 1
TWCNQHCTOGUTRB-UHFFFAOYSA-N 3-(4-chlorophenyl)-4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O TWCNQHCTOGUTRB-UHFFFAOYSA-N 0.000 claims 1
AJLJGWCTYZBDQA-UHFFFAOYSA-N 3-(4-chlorophenyl)-4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 AJLJGWCTYZBDQA-UHFFFAOYSA-N 0.000 claims 1
PCJFDYFYSAOPMZ-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl PCJFDYFYSAOPMZ-UHFFFAOYSA-N 0.000 claims 1
VYOHRIAPEJXCRD-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl VYOHRIAPEJXCRD-UHFFFAOYSA-N 0.000 claims 1
TULXKOCSNDHOBC-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=CC=C1Cl TULXKOCSNDHOBC-UHFFFAOYSA-N 0.000 claims 1
ACPDCMHBCLKTOE-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 ACPDCMHBCLKTOE-UHFFFAOYSA-N 0.000 claims 1
PHGMTQJBXXFRJO-UHFFFAOYSA-N 3-(4-chlorophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound C1=CC(Cl)=CC=C1C1=NN=C2N1CCCCC2 PHGMTQJBXXFRJO-UHFFFAOYSA-N 0.000 claims 1
WYBSOKBHOSUTJC-UHFFFAOYSA-N 3-(4-methoxyphenyl)-4-(2-methylprop-2-enyl)-1h-1,2,4-triazole-5-thione Chemical compound C1=CC(OC)=CC=C1C1=NNC(=S)N1CC(C)=C WYBSOKBHOSUTJC-UHFFFAOYSA-N 0.000 claims 1
LUGLLAHZGTUSAE-UHFFFAOYSA-N 3-(4-methoxyphenyl)-5,5,8,9-tetramethyl-6h-[1,2,4]triazolo[3,4-a]isoquinoline Chemical compound C1=CC(OC)=CC=C1C1=NN=C2N1C(C)(C)CC1=CC(C)=C(C)C=C12 LUGLLAHZGTUSAE-UHFFFAOYSA-N 0.000 claims 1
KXLBDDZCWXWYRL-UHFFFAOYSA-N 3-(4-methoxyphenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound C1=CC(OC)=CC=C1C1=NN=C2N1CCCCC2 KXLBDDZCWXWYRL-UHFFFAOYSA-N 0.000 claims 1
MDGGRHZKMXXZRD-UHFFFAOYSA-N 3-(4-methylphenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound C1=CC(C)=CC=C1C1=NN=C2N1CCCCC2 MDGGRHZKMXXZRD-UHFFFAOYSA-N 0.000 claims 1
MVXLFZJXAAYQJJ-UHFFFAOYSA-N 3-(4-tert-butylphenyl)-5-[(2,6-dichlorophenyl)methylsulfanyl]-4-(furan-2-ylmethyl)-1,2,4-triazole Chemical compound C1=CC(C(C)(C)C)=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC1=C(Cl)C=CC=C1Cl MVXLFZJXAAYQJJ-UHFFFAOYSA-N 0.000 claims 1
OUNBBIYHRZELDA-UHFFFAOYSA-N 3-(5,5-dimethyl-6h-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)phenol Chemical compound N12C(C)(C)CC3=CC=CC=C3C2=NN=C1C1=CC=CC(O)=C1 OUNBBIYHRZELDA-UHFFFAOYSA-N 0.000 claims 1
YGTVDHWYOZPHMY-UHFFFAOYSA-N 3-(5-benzylsulfanyl-4-ethyl-1,2,4-triazol-3-yl)-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=CC=C1 YGTVDHWYOZPHMY-UHFFFAOYSA-N 0.000 claims 1
VPHVTDGUKROOHL-UHFFFAOYSA-N 3-(5-benzylsulfanyl-4-ethyl-1,2,4-triazol-3-yl)pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=CC=C1 VPHVTDGUKROOHL-UHFFFAOYSA-N 0.000 claims 1
OBSJSIGVRWBCFL-UHFFFAOYSA-N 3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-2,7-dimethylimidazo[1,2-a]pyridine Chemical compound CC=1N=C2C=C(C)C=CN2C=1C(N1C)=NN=C1SCC1=CC=CC=C1 OBSJSIGVRWBCFL-UHFFFAOYSA-N 0.000 claims 1
HJNOSFFVUAXXSY-UHFFFAOYSA-N 3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-2-methylimidazo[1,2-a]pyridine Chemical compound CC=1N=C2C=CC=CN2C=1C(N1C)=NN=C1SCC1=CC=CC=C1 HJNOSFFVUAXXSY-UHFFFAOYSA-N 0.000 claims 1
MMSKOIQDXOUXSX-UHFFFAOYSA-N 3-(5-bromopyridin-3-yl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound BrC1=CN=CC(C=2N3CCCCCC3=NN=2)=C1 MMSKOIQDXOUXSX-UHFFFAOYSA-N 0.000 claims 1
YYCWXPFBQDRXTH-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O YYCWXPFBQDRXTH-UHFFFAOYSA-N 0.000 claims 1
QBVWFWOUVGMAJC-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 QBVWFWOUVGMAJC-UHFFFAOYSA-N 0.000 claims 1
CGKMIYPWIDPIEW-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 CGKMIYPWIDPIEW-UHFFFAOYSA-N 0.000 claims 1
SRBQTOUPIGSLSD-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 SRBQTOUPIGSLSD-UHFFFAOYSA-N 0.000 claims 1
JUMDBOWTNBNBAH-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O JUMDBOWTNBNBAH-UHFFFAOYSA-N 0.000 claims 1
AGWZHLWCSRPPHL-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 AGWZHLWCSRPPHL-UHFFFAOYSA-N 0.000 claims 1
KGEWKEKOCXUMHB-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 KGEWKEKOCXUMHB-UHFFFAOYSA-N 0.000 claims 1
QJNOKMXOENBCAV-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 QJNOKMXOENBCAV-UHFFFAOYSA-N 0.000 claims 1
DSTDGDBENPWUKI-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-5-(cyclohexylmethylsulfanyl)-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1CCCCC1 DSTDGDBENPWUKI-UHFFFAOYSA-N 0.000 claims 1
DEGHVHJRDUXQTB-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl DEGHVHJRDUXQTB-UHFFFAOYSA-N 0.000 claims 1
MQNCKDQKNKRLCB-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl MQNCKDQKNKRLCB-UHFFFAOYSA-N 0.000 claims 1
IZFUWGQEROOAMA-UHFFFAOYSA-N 3-(5-chlorothiophen-2-yl)-5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 IZFUWGQEROOAMA-UHFFFAOYSA-N 0.000 claims 1
UDKDUWDCNBRCHZ-UHFFFAOYSA-N 3-(5-hex-1-ynylpyridin-3-yl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound CCCCC#CC1=CN=CC(C=2N3CCCCCC3=NN=2)=C1 UDKDUWDCNBRCHZ-UHFFFAOYSA-N 0.000 claims 1
VJQYEVURLUHRTB-UHFFFAOYSA-N 3-(6-chloropyridin-3-yl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound C1=NC(Cl)=CC=C1C1=NN=C2N1CCCCC2 VJQYEVURLUHRTB-UHFFFAOYSA-N 0.000 claims 1
MODAQROJTGKNOV-UHFFFAOYSA-N 3-(cyclohexylmethylsulfanyl)-4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1CCCCC1 MODAQROJTGKNOV-UHFFFAOYSA-N 0.000 claims 1
HWFNQYPSZMBXGY-UHFFFAOYSA-N 3-(cyclohexylmethylsulfanyl)-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1CCCCC1 HWFNQYPSZMBXGY-UHFFFAOYSA-N 0.000 claims 1
AGFZJQDWVBDHHF-UHFFFAOYSA-N 3-(furan-2-yl)-5,5,8,9-tetramethyl-6h-[1,2,4]triazolo[3,4-a]isoquinoline Chemical compound N=1N=C2C=3C=C(C)C(C)=CC=3CC(C)(C)N2C=1C1=CC=CO1 AGFZJQDWVBDHHF-UHFFFAOYSA-N 0.000 claims 1
SQTDQYVVYDFZBN-UHFFFAOYSA-N 3-(furan-2-yl)-5,5-dimethyl-6h-[1,2,4]triazolo[3,4-a]isoquinoline Chemical compound N12C(C)(C)CC3=CC=CC=C3C2=NN=C1C1=CC=CO1 SQTDQYVVYDFZBN-UHFFFAOYSA-N 0.000 claims 1
BGFVNQHINQLFDX-UHFFFAOYSA-N 3-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl BGFVNQHINQLFDX-UHFFFAOYSA-N 0.000 claims 1
QERQFZYFMJSMCA-UHFFFAOYSA-N 3-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl QERQFZYFMJSMCA-UHFFFAOYSA-N 0.000 claims 1
UJIVCZXZMNVCFR-UHFFFAOYSA-N 3-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl UJIVCZXZMNVCFR-UHFFFAOYSA-N 0.000 claims 1
AJDRZYDXIDTOCN-UHFFFAOYSA-N 3-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-naphthalen-1-yl-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl AJDRZYDXIDTOCN-UHFFFAOYSA-N 0.000 claims 1
SAKNPYKNUYWQRS-UHFFFAOYSA-N 3-[(2,4-dichlorophenyl)methylsulfanyl]-5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl SAKNPYKNUYWQRS-UHFFFAOYSA-N 0.000 claims 1
LOJGCWANQZFGFB-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl LOJGCWANQZFGFB-UHFFFAOYSA-N 0.000 claims 1
OEKRFTKYTLFADR-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl OEKRFTKYTLFADR-UHFFFAOYSA-N 0.000 claims 1
YZXXYFLKJPWWHU-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl YZXXYFLKJPWWHU-UHFFFAOYSA-N 0.000 claims 1
DITBEPNZCZFQCA-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl DITBEPNZCZFQCA-UHFFFAOYSA-N 0.000 claims 1
XXZRCWAGJZZABV-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl XXZRCWAGJZZABV-UHFFFAOYSA-N 0.000 claims 1
SVIHRIYPMJSUGY-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-5-naphthalen-1-yl-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl SVIHRIYPMJSUGY-UHFFFAOYSA-N 0.000 claims 1
XBBJHCGKPFKHTM-UHFFFAOYSA-N 3-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl XBBJHCGKPFKHTM-UHFFFAOYSA-N 0.000 claims 1
IDKORPCVVKPQDI-UHFFFAOYSA-N 3-[(2-bromophenyl)methylsulfanyl]-4-methyl-5-(4-nitrophenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)[N+]([O-])=O)N(C)C=1SCC1=CC=CC=C1Br IDKORPCVVKPQDI-UHFFFAOYSA-N 0.000 claims 1
IRYHRUBBGYXNIL-UHFFFAOYSA-N 3-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=CC=C1Cl IRYHRUBBGYXNIL-UHFFFAOYSA-N 0.000 claims 1
COORSKCUQTXUFA-UHFFFAOYSA-N 3-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=CC=C1Cl COORSKCUQTXUFA-UHFFFAOYSA-N 0.000 claims 1
GAUAYWJNBPTGLG-UHFFFAOYSA-N 3-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=CC=C1Cl GAUAYWJNBPTGLG-UHFFFAOYSA-N 0.000 claims 1
ZSICKQQNKZOXBJ-UHFFFAOYSA-N 3-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 ZSICKQQNKZOXBJ-UHFFFAOYSA-N 0.000 claims 1
LUOKHYJDRWQRRY-UHFFFAOYSA-N 3-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 LUOKHYJDRWQRRY-UHFFFAOYSA-N 0.000 claims 1
AQXZWGFZOLXGNA-UHFFFAOYSA-N 3-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 AQXZWGFZOLXGNA-UHFFFAOYSA-N 0.000 claims 1
XKSAONHUJOUUDX-UHFFFAOYSA-N 3-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 XKSAONHUJOUUDX-UHFFFAOYSA-N 0.000 claims 1
IHDCPKXRIKICLN-UHFFFAOYSA-N 3-[(3,4-dichlorophenyl)methylsulfanyl]-5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 IHDCPKXRIKICLN-UHFFFAOYSA-N 0.000 claims 1
ZJSXIHSBVFDSER-UHFFFAOYSA-N 3-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 ZJSXIHSBVFDSER-UHFFFAOYSA-N 0.000 claims 1
PMKANHCXMHJNHL-UHFFFAOYSA-N 3-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 PMKANHCXMHJNHL-UHFFFAOYSA-N 0.000 claims 1
ODWAPLZHNWQTNS-UHFFFAOYSA-N 3-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 ODWAPLZHNWQTNS-UHFFFAOYSA-N 0.000 claims 1
KMZZIBWYKJTLCK-UHFFFAOYSA-N 3-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 KMZZIBWYKJTLCK-UHFFFAOYSA-N 0.000 claims 1
MYUAHKWKJFPTEA-UHFFFAOYSA-N 3-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 MYUAHKWKJFPTEA-UHFFFAOYSA-N 0.000 claims 1
FEJSQOZDTHOEPJ-UHFFFAOYSA-N 3-[(3,5-dimethoxyphenyl)methylsulfanyl]-5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 FEJSQOZDTHOEPJ-UHFFFAOYSA-N 0.000 claims 1
FLUACYKOEXGOCO-UHFFFAOYSA-N 3-[(3-methoxyphenyl)methylsulfanyl]-4-methyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound COC1=CC=CC(CSC=2N(C(C=3SC=CC=3)=NN=2)C)=C1 FLUACYKOEXGOCO-UHFFFAOYSA-N 0.000 claims 1
WZFWCZCJXWJYTD-UHFFFAOYSA-N 3-[(4-bromophenyl)methylsulfanyl]-4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 WZFWCZCJXWJYTD-UHFFFAOYSA-N 0.000 claims 1
IOKZATWVPBLTGG-UHFFFAOYSA-N 3-[(4-bromophenyl)methylsulfanyl]-4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 IOKZATWVPBLTGG-UHFFFAOYSA-N 0.000 claims 1
TVUKXMVXBQEEDL-UHFFFAOYSA-N 3-[(4-bromophenyl)methylsulfanyl]-4-ethyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 TVUKXMVXBQEEDL-UHFFFAOYSA-N 0.000 claims 1
HGEFRRPCYFAVNP-UHFFFAOYSA-N 3-[(4-bromophenyl)methylsulfanyl]-5-(5-chlorothiophen-2-yl)-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 HGEFRRPCYFAVNP-UHFFFAOYSA-N 0.000 claims 1
XWQFBDANJFMJGA-UHFFFAOYSA-N 3-[(4-chlorophenyl)methylsulfanyl]-4-ethyl-5-(4-nitrophenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1SCC1=CC=C(Cl)C=C1 XWQFBDANJFMJGA-UHFFFAOYSA-N 0.000 claims 1
PTBOVXACVWXRBG-UHFFFAOYSA-N 3-[(4-fluorophenyl)methylsulfanyl]-4-methyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(C)C=1SCC1=CC=C(F)C=C1 PTBOVXACVWXRBG-UHFFFAOYSA-N 0.000 claims 1
NPABVKBKBFUMHA-UHFFFAOYSA-N 3-[(4-methoxyphenyl)methylsulfanyl]-4-methyl-5-phenyl-1,2,4-triazole Chemical compound C1=CC(OC)=CC=C1CSC(N1C)=NN=C1C1=CC=CC=C1 NPABVKBKBFUMHA-UHFFFAOYSA-N 0.000 claims 1
LBBOQIQYPQBDHO-UHFFFAOYSA-N 3-[(4-tert-butylphenyl)methylsulfanyl]-4-methyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(C)C=1SCC1=CC=C(C(C)(C)C)C=C1 LBBOQIQYPQBDHO-UHFFFAOYSA-N 0.000 claims 1
CJZFSHKTPZNMBF-UHFFFAOYSA-N 3-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=CC=C1OC CJZFSHKTPZNMBF-UHFFFAOYSA-N 0.000 claims 1
CWBMMSLNAYLRPT-UHFFFAOYSA-N 3-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=CC=C1OC1=CC=CC=C1 CWBMMSLNAYLRPT-UHFFFAOYSA-N 0.000 claims 1
NJRAIMZHLZAZJT-UHFFFAOYSA-N 3-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=C(OC)C=C1 NJRAIMZHLZAZJT-UHFFFAOYSA-N 0.000 claims 1
SFQFCEXIVZTHGU-UHFFFAOYSA-N 3-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=C(C)S1 SFQFCEXIVZTHGU-UHFFFAOYSA-N 0.000 claims 1
UDPBMSXXHPBWDF-UHFFFAOYSA-N 3-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C(=C1C(F)(F)F)C=NN1C1=CC=CC=C1 UDPBMSXXHPBWDF-UHFFFAOYSA-N 0.000 claims 1
CUIUQAMNEKABRY-UHFFFAOYSA-N 3-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-5-thiophen-2-yl-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=CS1 CUIUQAMNEKABRY-UHFFFAOYSA-N 0.000 claims 1
KVFIPBBQJARLOV-UHFFFAOYSA-N 3-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazole Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C(C=C1)=CC=C1N1C(C)=CC=C1C KVFIPBBQJARLOV-UHFFFAOYSA-N 0.000 claims 1
AESWMSCLVNNIQD-UHFFFAOYSA-N 3-[1-(1h-indole-5-carbonyl)piperidin-4-yl]-1h-benzimidazol-2-one Chemical compound C1=C2NC=CC2=CC(C(N2CCC(CC2)N2C(NC3=CC=CC=C32)=O)=O)=C1 AESWMSCLVNNIQD-UHFFFAOYSA-N 0.000 claims 1
IWUWWHBHHKXIDC-UHFFFAOYSA-N 3-[2-(phenylmethoxymethyl)phenyl]-2,4,5-triazatricyclo[5.3.1.02,6]undeca-3,5-diene Chemical compound C=1C=CC=C(C=2N3C4CC(CCC4)C3=NN=2)C=1COCC1=CC=CC=C1 IWUWWHBHHKXIDC-UHFFFAOYSA-N 0.000 claims 1
CKHBZLXXKPRRNV-UHFFFAOYSA-N 3-[3-(4-ethoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidin-2-yl]piperidine-1-carbaldehyde Chemical compound C1=CC(OCC)=CC=C1C1=C2N=CC=C(C)N2N=C1C1CN(C=O)CCC1 CKHBZLXXKPRRNV-UHFFFAOYSA-N 0.000 claims 1
UJJSZCSLQQMCEA-UHFFFAOYSA-N 3-[3-[(2,4-dichlorophenyl)methoxy]thiophen-2-yl]-4-methyl-1h-1,2,4-triazole-5-thione Chemical compound N1C(=S)N(C)C(C2=C(C=CS2)OCC=2C(=CC(Cl)=CC=2)Cl)=N1 UJJSZCSLQQMCEA-UHFFFAOYSA-N 0.000 claims 1
FWYLPZHZJQXRCC-UHFFFAOYSA-N 3-[3-[(2,4-dichlorophenyl)methoxy]thiophen-2-yl]-4-methyl-5-methylsulfanyl-1,2,4-triazole Chemical compound CN1C(SC)=NN=C1C1=C(OCC=2C(=CC(Cl)=CC=2)Cl)C=CS1 FWYLPZHZJQXRCC-UHFFFAOYSA-N 0.000 claims 1
WUKSKSMKGWHRNF-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O WUKSKSMKGWHRNF-UHFFFAOYSA-N 0.000 claims 1
RDMZQNGHMYNXHB-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 RDMZQNGHMYNXHB-UHFFFAOYSA-N 0.000 claims 1
FGBONUAUMBDMJP-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(OC)C=C1 FGBONUAUMBDMJP-UHFFFAOYSA-N 0.000 claims 1
RYPBPPUWFCBFPP-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 RYPBPPUWFCBFPP-UHFFFAOYSA-N 0.000 claims 1
YEBXQSPQBBWMHD-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 YEBXQSPQBBWMHD-UHFFFAOYSA-N 0.000 claims 1
HNJLAXQOGWIJNY-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O HNJLAXQOGWIJNY-UHFFFAOYSA-N 0.000 claims 1
UZYKFACDGDQGID-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 UZYKFACDGDQGID-UHFFFAOYSA-N 0.000 claims 1
IQZQPIQRXJBMNP-UHFFFAOYSA-N 3-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 IQZQPIQRXJBMNP-UHFFFAOYSA-N 0.000 claims 1
JPKCHGNOMVKVFU-UHFFFAOYSA-N 3-[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O JPKCHGNOMVKVFU-UHFFFAOYSA-N 0.000 claims 1
AXLZXXSFCOIMNB-UHFFFAOYSA-N 3-[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=CC=C1[N+]([O-])=O AXLZXXSFCOIMNB-UHFFFAOYSA-N 0.000 claims 1
FCLJMOCSQSZVBA-UHFFFAOYSA-N 3-[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O FCLJMOCSQSZVBA-UHFFFAOYSA-N 0.000 claims 1
NMXDDCIDHCFWOV-UHFFFAOYSA-N 3-[4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=CC([N+]([O-])=O)=C1 NMXDDCIDHCFWOV-UHFFFAOYSA-N 0.000 claims 1
RKSOGEXMQNGICA-UHFFFAOYSA-N 3-[4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 RKSOGEXMQNGICA-UHFFFAOYSA-N 0.000 claims 1
UPHYKYARZIXRIB-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 UPHYKYARZIXRIB-UHFFFAOYSA-N 0.000 claims 1
HXZYKKYLHOJMQK-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=C(C)C=C1 HXZYKKYLHOJMQK-UHFFFAOYSA-N 0.000 claims 1
HXNVXTNSOQDIAV-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 HXNVXTNSOQDIAV-UHFFFAOYSA-N 0.000 claims 1
DABBXGIEQXBRBS-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 DABBXGIEQXBRBS-UHFFFAOYSA-N 0.000 claims 1
NLABIGWVHQVUNX-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=C(S(C)(=O)=O)C=C1 NLABIGWVHQVUNX-UHFFFAOYSA-N 0.000 claims 1
BLXHHWJLQHRCRE-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 BLXHHWJLQHRCRE-UHFFFAOYSA-N 0.000 claims 1
QOOSBVXUMBBSIM-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 QOOSBVXUMBBSIM-UHFFFAOYSA-N 0.000 claims 1
JPMQUJRZAOCXCM-UHFFFAOYSA-N 3-[4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 JPMQUJRZAOCXCM-UHFFFAOYSA-N 0.000 claims 1
KBHMOSDOPCSSSJ-UHFFFAOYSA-N 3-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O KBHMOSDOPCSSSJ-UHFFFAOYSA-N 0.000 claims 1
XNEUNIPTDIKTHX-UHFFFAOYSA-N 3-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC(C)=CC=C1[N+]([O-])=O XNEUNIPTDIKTHX-UHFFFAOYSA-N 0.000 claims 1
DKXLSAPVUXSUPS-UHFFFAOYSA-N 3-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O DKXLSAPVUXSUPS-UHFFFAOYSA-N 0.000 claims 1
PWTPVTAMRQRLLE-UHFFFAOYSA-N 3-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 PWTPVTAMRQRLLE-UHFFFAOYSA-N 0.000 claims 1
MUUMKPOBYXXBQQ-UHFFFAOYSA-N 3-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=CC(OC(F)(F)F)=C1 MUUMKPOBYXXBQQ-UHFFFAOYSA-N 0.000 claims 1
INXKOPLFUHPDKT-UHFFFAOYSA-N 3-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 INXKOPLFUHPDKT-UHFFFAOYSA-N 0.000 claims 1
LIQKCJGUBVDPRD-UHFFFAOYSA-N 3-[4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 LIQKCJGUBVDPRD-UHFFFAOYSA-N 0.000 claims 1
SRNOJCSARXWTAT-UHFFFAOYSA-N 3-[4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 SRNOJCSARXWTAT-UHFFFAOYSA-N 0.000 claims 1
JXHVHSWQECWVRF-UHFFFAOYSA-N 3-[4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 JXHVHSWQECWVRF-UHFFFAOYSA-N 0.000 claims 1
NNFOYWRVDVJJKX-UHFFFAOYSA-N 3-[4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=C(C(F)(F)F)C=C1 NNFOYWRVDVJJKX-UHFFFAOYSA-N 0.000 claims 1
LTPRKFGJHMENLP-UHFFFAOYSA-N 3-[4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 LTPRKFGJHMENLP-UHFFFAOYSA-N 0.000 claims 1
PGZCWMRBISUIIZ-UHFFFAOYSA-N 3-[5-(cyclohexylmethylsulfanyl)-4-ethyl-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1CCCCC1 PGZCWMRBISUIIZ-UHFFFAOYSA-N 0.000 claims 1
RNFVTUFEPVBIQP-UHFFFAOYSA-N 3-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl RNFVTUFEPVBIQP-UHFFFAOYSA-N 0.000 claims 1
SFGLOWGRYQQGLR-UHFFFAOYSA-N 3-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2,8-dimethylimidazo[1,2-a]pyridine Chemical compound CC=1N=C2C(C)=CC=CN2C=1C(N1C)=NN=C1SCC1=CC=C(Cl)C=C1Cl SFGLOWGRYQQGLR-UHFFFAOYSA-N 0.000 claims 1
RAXDJEDVIWAWJP-UHFFFAOYSA-N 3-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(C)C=1SCC1=CC=C(Cl)C=C1Cl RAXDJEDVIWAWJP-UHFFFAOYSA-N 0.000 claims 1
BPGDCBSWZVKJOA-UHFFFAOYSA-N 3-[5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl BPGDCBSWZVKJOA-UHFFFAOYSA-N 0.000 claims 1
NYPCKFBNUJIGCD-UHFFFAOYSA-N 3-[5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=C(Cl)C=CC=C1Cl NYPCKFBNUJIGCD-UHFFFAOYSA-N 0.000 claims 1
MOELOLORCAQMQB-UHFFFAOYSA-N 3-[5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=C(Cl)C=CC=C1Cl MOELOLORCAQMQB-UHFFFAOYSA-N 0.000 claims 1
ZUDRZNYQBNGXPM-UHFFFAOYSA-N 3-[5-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=CC=C1Cl ZUDRZNYQBNGXPM-UHFFFAOYSA-N 0.000 claims 1
YCRQXBFFTSUFSD-UHFFFAOYSA-N 3-[5-[(2-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=CC=C1Cl YCRQXBFFTSUFSD-UHFFFAOYSA-N 0.000 claims 1
ZTFNZLSGIUNRPY-UHFFFAOYSA-N 3-[5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 ZTFNZLSGIUNRPY-UHFFFAOYSA-N 0.000 claims 1
DPBJNGLWHONYCE-UHFFFAOYSA-N 3-[5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=C(Cl)C(Cl)=C1 DPBJNGLWHONYCE-UHFFFAOYSA-N 0.000 claims 1
LASUOURWKYTOJW-UHFFFAOYSA-N 3-[5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(Cl)C(Cl)=C1 LASUOURWKYTOJW-UHFFFAOYSA-N 0.000 claims 1
MHSYANCLYJRZTL-UHFFFAOYSA-N 3-[5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]-2-methylsulfanylpyridine Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 MHSYANCLYJRZTL-UHFFFAOYSA-N 0.000 claims 1
KLDKEMLPJDQPJH-UHFFFAOYSA-N 3-[5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 KLDKEMLPJDQPJH-UHFFFAOYSA-N 0.000 claims 1
KNMXXBFVHJMKDN-UHFFFAOYSA-N 3-[5-[(4-bromophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 KNMXXBFVHJMKDN-UHFFFAOYSA-N 0.000 claims 1
XKXAJDFJLYIQJB-UHFFFAOYSA-N 3-[5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylimidazo[1,2-a]pyridine Chemical compound CC=1N=C2C=CC=CN2C=1C(N1C)=NN=C1SCC1=CC=C(Cl)C=C1 XKXAJDFJLYIQJB-UHFFFAOYSA-N 0.000 claims 1
HMCIWMFYUATCTC-UHFFFAOYSA-N 3-[5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]propan-1-ol Chemical compound CCN1C(CCCO)=NN=C1SCC(C(=C1)Cl)=CC2=C1OCO2 HMCIWMFYUATCTC-UHFFFAOYSA-N 0.000 claims 1
SPZCCCZYZKOXPB-UHFFFAOYSA-N 3-[5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=CN=C1 SPZCCCZYZKOXPB-UHFFFAOYSA-N 0.000 claims 1
IIOLFLLTNUCVFD-UHFFFAOYSA-N 3-[5-benzylsulfanyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]pyridine Chemical compound C=1C=CC=CC=1CCN(C(=NN=1)C=2C=NC=CC=2)C=1SCC1=CC=CC=C1 IIOLFLLTNUCVFD-UHFFFAOYSA-N 0.000 claims 1
OEEOQHRWDRRUFD-UHFFFAOYSA-N 3-[[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=CC=C1[N+]([O-])=O OEEOQHRWDRRUFD-UHFFFAOYSA-N 0.000 claims 1
WDXRSQOCSNDAAG-UHFFFAOYSA-N 3-[[4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=CC([N+]([O-])=O)=C1 WDXRSQOCSNDAAG-UHFFFAOYSA-N 0.000 claims 1
PWUOMGRMJCGQDL-UHFFFAOYSA-N 3-[[4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=C(OC)C=C1 PWUOMGRMJCGQDL-UHFFFAOYSA-N 0.000 claims 1
YYIKXVRFVIHXGM-UHFFFAOYSA-N 3-[[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=C(S(C)(=O)=O)C=C1 YYIKXVRFVIHXGM-UHFFFAOYSA-N 0.000 claims 1
IOVHAPVHRXPUIX-UHFFFAOYSA-N 3-[[4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=C([N+]([O-])=O)C=C1 IOVHAPVHRXPUIX-UHFFFAOYSA-N 0.000 claims 1
ZGPUQSLZCVSYOW-UHFFFAOYSA-N 3-[[4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 ZGPUQSLZCVSYOW-UHFFFAOYSA-N 0.000 claims 1
RTRZIKHCPVUJRO-UHFFFAOYSA-N 3-[[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC(C)=CC=C1[N+]([O-])=O RTRZIKHCPVUJRO-UHFFFAOYSA-N 0.000 claims 1
KXLMJGGWGIGLQZ-UHFFFAOYSA-N 3-[[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=CC(OC(F)(F)F)=C1 KXLMJGGWGIGLQZ-UHFFFAOYSA-N 0.000 claims 1
QPGIJIRGLAVNSV-UHFFFAOYSA-N 3-[[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carbonyl]amino]propanoic acid Chemical compound C1=C2NC=C(C(=O)NCCC(O)=O)C2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 QPGIJIRGLAVNSV-UHFFFAOYSA-N 0.000 claims 1
XMZOCSCCWOIESM-UHFFFAOYSA-N 3-[[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=C(Cl)C=C1Cl XMZOCSCCWOIESM-UHFFFAOYSA-N 0.000 claims 1
JWAKVDYLOYTRAI-UHFFFAOYSA-N 3-[[5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=C(Cl)C=CC=C1Cl JWAKVDYLOYTRAI-UHFFFAOYSA-N 0.000 claims 1
IYQNQRHORBZDKL-UHFFFAOYSA-N 3-[[5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=C(Cl)C(Cl)=C1 IYQNQRHORBZDKL-UHFFFAOYSA-N 0.000 claims 1
LAFGXKLOHXWNCS-UHFFFAOYSA-N 3-[[5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]methyl]-1h-indole Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC(OC)=CC(OC)=C1 LAFGXKLOHXWNCS-UHFFFAOYSA-N 0.000 claims 1
DFDCVQAGGAQLPM-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl(1h-imidazol-5-yl)methanone Chemical compound C1C(CC2)CCC2CN1C(=O)C1=CNC=N1 DFDCVQAGGAQLPM-UHFFFAOYSA-N 0.000 claims 1
OMWOJLYJWCJZBS-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl(1h-indol-3-yl)methanone Chemical compound C1CC(C2)CCC1CN2C(=O)C1=CNC2=CC=CC=C12 OMWOJLYJWCJZBS-UHFFFAOYSA-N 0.000 claims 1
CRQKCCXRMKLINA-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl(1h-indol-5-yl)methanone Chemical compound C1CC(C2)CCC1CN2C(=O)C1=CC=C(NC=C2)C2=C1 CRQKCCXRMKLINA-UHFFFAOYSA-N 0.000 claims 1
UEOPWQUBKNHVMA-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl(quinolin-2-yl)methanone Chemical compound C1CC(C2)CCC1CN2C(=O)C1=CC=C(C=CC=C2)C2=N1 UEOPWQUBKNHVMA-UHFFFAOYSA-N 0.000 claims 1
DNLQVIGADVTFPN-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl-(1-methylindol-3-yl)methanone Chemical compound C1CC(C2)CCC1CN2C(=O)C1=CN(C)C2=CC=CC=C21 DNLQVIGADVTFPN-UHFFFAOYSA-N 0.000 claims 1
PFGGHCQDRUHGQF-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl-(2,4-dimethyl-1,3-thiazol-5-yl)methanone Chemical compound S1C(C)=NC(C)=C1C(=O)N1CC(CC2)CCC2C1 PFGGHCQDRUHGQF-UHFFFAOYSA-N 0.000 claims 1
NXOVBRAJXCOONU-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl-(2-bromophenyl)methanone Chemical compound BrC1=CC=CC=C1C(=O)N1CC(CC2)CCC2C1 NXOVBRAJXCOONU-UHFFFAOYSA-N 0.000 claims 1
NTLUMMHVTHLTLV-UHFFFAOYSA-N 3-azabicyclo[3.2.2]nonan-3-yl-(4-methyl-2-phenyl-1,3-thiazol-5-yl)methanone Chemical compound S1C(C(=O)N2CC3CCC(CC3)C2)=C(C)N=C1C1=CC=CC=C1 NTLUMMHVTHLTLV-UHFFFAOYSA-N 0.000 claims 1
IOUVKGGHRRTOHA-UHFFFAOYSA-N 3-benzyl-4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(SCC=2C(=CC=CC=2)[N+]([O-])=O)N(CC)C=1CC1=CC=CC=C1 IOUVKGGHRRTOHA-UHFFFAOYSA-N 0.000 claims 1
YETRWAVEVYCBJG-UHFFFAOYSA-N 3-benzyl-4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(SCC=2C=CC(OC)=CC=2)N(CC)C=1CC1=CC=CC=C1 YETRWAVEVYCBJG-UHFFFAOYSA-N 0.000 claims 1
SPGKHGVGMWIKEH-UHFFFAOYSA-N 3-benzyl-4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(SCC=2C=CC(C)=CC=2)N(CC)C=1CC1=CC=CC=C1 SPGKHGVGMWIKEH-UHFFFAOYSA-N 0.000 claims 1
DCMJNEXEPFHOJH-UHFFFAOYSA-N 3-benzyl-4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(SCC=2C(=CC=C(C)C=2)[N+]([O-])=O)N(CC)C=1CC1=CC=CC=C1 DCMJNEXEPFHOJH-UHFFFAOYSA-N 0.000 claims 1
DOMVEPZAHSQDKM-UHFFFAOYSA-N 3-benzyl-4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(SCC=2C=CC(=CC=2)C(F)(F)F)N(CC)C=1CC1=CC=CC=C1 DOMVEPZAHSQDKM-UHFFFAOYSA-N 0.000 claims 1
PSBSJXFQHPXRLP-UHFFFAOYSA-N 3-benzyl-5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(SCC=2C(=CC(Cl)=CC=2)Cl)N(CC)C=1CC1=CC=CC=C1 PSBSJXFQHPXRLP-UHFFFAOYSA-N 0.000 claims 1
OQHBWSLNFUSMQP-UHFFFAOYSA-N 3-benzyl-5-[(2,6-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(SCC=2C(=CC=CC=2Cl)Cl)N(CC)C=1CC1=CC=CC=C1 OQHBWSLNFUSMQP-UHFFFAOYSA-N 0.000 claims 1
DBFWVYFXFUDNRN-UHFFFAOYSA-N 3-benzyl-5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazole Chemical compound N=1N=C(SCC=2C(=CC=CC=2F)Cl)N(C)C=1CC1=CC=CC=C1 DBFWVYFXFUDNRN-UHFFFAOYSA-N 0.000 claims 1
DJSHOVRQEUVJFW-UHFFFAOYSA-N 3-benzyl-5-[(3,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(SCC=2C=C(Cl)C(Cl)=CC=2)N(CC)C=1CC1=CC=CC=C1 DJSHOVRQEUVJFW-UHFFFAOYSA-N 0.000 claims 1
DQRONKYBFVOFDF-UHFFFAOYSA-N 3-benzyl-5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(SCC=2C=C(OC)C=C(OC)C=2)N(CC)C=1CC1=CC=CC=C1 DQRONKYBFVOFDF-UHFFFAOYSA-N 0.000 claims 1
HSQIYJMQYYYHJT-UHFFFAOYSA-N 3-benzyl-5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazole Chemical compound N=1N=C(SCC=2C=CC(Cl)=CC=2)N(C)C=1CC1=CC=CC=C1 HSQIYJMQYYYHJT-UHFFFAOYSA-N 0.000 claims 1
ZNTLWYFQGSFBOM-UHFFFAOYSA-N 3-benzyl-5-benzylsulfanyl-4-ethyl-1,2,4-triazole;4-[5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(SCC=2C=CC=CC=2)N(CC)C=1CC1=CC=CC=C1.N=1N=C(C=2C=CN=CC=2)N(C)C=1SCC1=C(F)C=CC=C1Cl ZNTLWYFQGSFBOM-UHFFFAOYSA-N 0.000 claims 1
WYRSPYXQDGIYCX-UHFFFAOYSA-N 3-benzylsulfanyl-4-ethyl-5-(4-nitrophenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1SCC1=CC=CC=C1 WYRSPYXQDGIYCX-UHFFFAOYSA-N 0.000 claims 1
KMBWUQZURFUDPU-UHFFFAOYSA-N 3-benzylsulfanyl-4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=CC=C1 KMBWUQZURFUDPU-UHFFFAOYSA-N 0.000 claims 1
FTAOJWXRTKNZQX-UHFFFAOYSA-N 3-benzylsulfanyl-4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=CC=C1 FTAOJWXRTKNZQX-UHFFFAOYSA-N 0.000 claims 1
GJFQTEDCEPUYKK-UHFFFAOYSA-N 3-benzylsulfanyl-4-methyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazole Chemical compound COC1=C(OC)C(OC)=CC(C=2N(C(SCC=3C=CC=CC=3)=NN=2)C)=C1 GJFQTEDCEPUYKK-UHFFFAOYSA-N 0.000 claims 1
ICFSYQMPQQLGAZ-UHFFFAOYSA-N 3-benzylsulfanyl-5-(2-methoxyphenyl)-4-methyl-1,2,4-triazole Chemical compound COC1=CC=CC=C1C(N1C)=NN=C1SCC1=CC=CC=C1 ICFSYQMPQQLGAZ-UHFFFAOYSA-N 0.000 claims 1
LRXYRGFVYAHAPZ-UHFFFAOYSA-N 3-benzylsulfanyl-5-(4-methoxyphenyl)-4-methyl-1,2,4-triazole Chemical compound C1=CC(OC)=CC=C1C(N1C)=NN=C1SCC1=CC=CC=C1 LRXYRGFVYAHAPZ-UHFFFAOYSA-N 0.000 claims 1
PTXXAXRTWMNCAY-UHFFFAOYSA-N 3-benzylsulfanyl-5-[(4-chlorophenoxy)methyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(SCC=2C=CC=CC=2)N(CC)C=1COC1=CC=C(Cl)C=C1 PTXXAXRTWMNCAY-UHFFFAOYSA-N 0.000 claims 1
CTLUIFMJDKYDLR-UHFFFAOYSA-N 3-benzylsulfanyl-5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=CC=C1 CTLUIFMJDKYDLR-UHFFFAOYSA-N 0.000 claims 1
ZAUZWUWDJQIXBT-UHFFFAOYSA-N 3-butylsulfanyl-4-methyl-5-(4-methylphenyl)-1,2,4-triazole Chemical compound CN1C(SCCCC)=NN=C1C1=CC=C(C)C=C1 ZAUZWUWDJQIXBT-UHFFFAOYSA-N 0.000 claims 1
BEZMPZHXXHOHJX-UHFFFAOYSA-N 3-butylsulfanyl-5-(4-methoxyphenyl)-4-methyl-1,2,4-triazole Chemical compound CN1C(SCCCC)=NN=C1C1=CC=C(OC)C=C1 BEZMPZHXXHOHJX-UHFFFAOYSA-N 0.000 claims 1
ARIRKQATFICMBJ-UHFFFAOYSA-N 3-cyclohexyl-4-methyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1CSC(N1C)=NN=C1C1CCCCC1 ARIRKQATFICMBJ-UHFFFAOYSA-N 0.000 claims 1
YNCFPURBKVPYQF-UHFFFAOYSA-N 3-phenyl-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound N12CCCCCC2=NN=C1C1=CC=CC=C1 YNCFPURBKVPYQF-UHFFFAOYSA-N 0.000 claims 1
XCNFBPXYJPORHD-UHFFFAOYSA-N 3-pyridin-3-yl-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepine Chemical compound N12CCCCCC2=NN=C1C1=CC=CN=C1 XCNFBPXYJPORHD-UHFFFAOYSA-N 0.000 claims 1
RZQQPARKDTYYBY-UHFFFAOYSA-N 3-pyridin-4-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine Chemical compound N12CCCCCC2=NN=C1C1=CC=NC=C1 RZQQPARKDTYYBY-UHFFFAOYSA-N 0.000 claims 1
RCLJQROXNMOEMP-UHFFFAOYSA-N 4-(2-methoxyethyl)-3-(2-methoxyethylsulfanyl)-5-(2-methoxyphenyl)-1,2,4-triazole Chemical compound COCCN1C(SCCOC)=NN=C1C1=CC=CC=C1OC RCLJQROXNMOEMP-UHFFFAOYSA-N 0.000 claims 1
VIOJWBKZFNFVQY-UHFFFAOYSA-N 4-(2-methoxyethyl)-3-(2-methoxyethylsulfanyl)-5-thiophen-2-yl-1,2,4-triazole Chemical compound COCCN1C(SCCOC)=NN=C1C1=CC=CS1 VIOJWBKZFNFVQY-UHFFFAOYSA-N 0.000 claims 1
CZNDCWPMEWXZST-UHFFFAOYSA-N 4-(2-methylprop-2-enyl)-3-(3-nitrophenyl)-1h-1,2,4-triazole-5-thione Chemical compound N1C(=S)N(CC(=C)C)C(C=2C=C(C=CC=2)[N+]([O-])=O)=N1 CZNDCWPMEWXZST-UHFFFAOYSA-N 0.000 claims 1
CFIUCNIQKGZBST-UHFFFAOYSA-N 4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)benzoic acid Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C1=CC=C(C(O)=O)C=C1 CFIUCNIQKGZBST-UHFFFAOYSA-N 0.000 claims 1
HKTQOOXXOJKOIL-UHFFFAOYSA-N 4-(3-azabicyclo[3.2.2]nonane-3-carbonyl)-n,n-dipropylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N(CCC)CCC)=CC=C1C(=O)N1CC(CC2)CCC2C1 HKTQOOXXOJKOIL-UHFFFAOYSA-N 0.000 claims 1
SGYXEVXIIHLTEZ-UHFFFAOYSA-N 4-(5-benzylsulfanyl-4-ethyl-1,2,4-triazol-3-yl)phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=CC=C1 SGYXEVXIIHLTEZ-UHFFFAOYSA-N 0.000 claims 1
JCZBBVNPUTYAAC-UHFFFAOYSA-N 4-(cyclopropylmethyl)-3-(2-methoxyethylsulfanyl)-5-(2-methoxyphenyl)-1,2,4-triazole Chemical compound C1CC1CN1C(SCCOC)=NN=C1C1=CC=CC=C1OC JCZBBVNPUTYAAC-UHFFFAOYSA-N 0.000 claims 1
RXMBMELQHQSJGV-UHFFFAOYSA-N 4-(cyclopropylmethyl)-3-(2-methoxyethylsulfanyl)-5-thiophen-2-yl-1,2,4-triazole Chemical compound C1CC1CN1C(SCCOC)=NN=C1C1=CC=CS1 RXMBMELQHQSJGV-UHFFFAOYSA-N 0.000 claims 1
ULVGPDHDQCFQNY-UHFFFAOYSA-N 4-[(4-ethyl-5-pyridin-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 ULVGPDHDQCFQNY-UHFFFAOYSA-N 0.000 claims 1
QYHXSEZWVZUXTI-UHFFFAOYSA-N 4-[(4-ethyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 QYHXSEZWVZUXTI-UHFFFAOYSA-N 0.000 claims 1
JFNZJTCAVNOXBH-UHFFFAOYSA-N 4-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 JFNZJTCAVNOXBH-UHFFFAOYSA-N 0.000 claims 1
NJXJQFGWDYJOCB-UHFFFAOYSA-N 4-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 NJXJQFGWDYJOCB-UHFFFAOYSA-N 0.000 claims 1
HXYCAHGRZCVYRG-UHFFFAOYSA-N 4-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile Chemical compound N=1N=C(SCC=2C=CC(=CC=2)C#N)N(CC)C=1CC1=CC=CC=C1 HXYCAHGRZCVYRG-UHFFFAOYSA-N 0.000 claims 1
UWRNQBNLENHGBY-UHFFFAOYSA-N 4-[2-(2,6-dichlorophenyl)sulfanylethyl]-n-[2-(2-fluorophenyl)ethyl]benzamide Chemical compound FC1=CC=CC=C1CCNC(=O)C(C=C1)=CC=C1CCSC1=C(Cl)C=CC=C1Cl UWRNQBNLENHGBY-UHFFFAOYSA-N 0.000 claims 1
FKZKHWLNLOEBAC-UHFFFAOYSA-N 4-[2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]morpholine Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCCN1CCOCC1 FKZKHWLNLOEBAC-UHFFFAOYSA-N 0.000 claims 1
CBLGYZSCFONDCM-UHFFFAOYSA-N 4-[4-[(4-ethyl-5-pyridin-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 CBLGYZSCFONDCM-UHFFFAOYSA-N 0.000 claims 1
YZPPYFXZDDQXQB-UHFFFAOYSA-N 4-[4-[(4-ethyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 YZPPYFXZDDQXQB-UHFFFAOYSA-N 0.000 claims 1
GPDLQULFHHPNGY-UHFFFAOYSA-N 4-[4-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 GPDLQULFHHPNGY-UHFFFAOYSA-N 0.000 claims 1
XHXDJDGNDJOWIH-UHFFFAOYSA-N 4-[4-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(SCC=2C=CC(=CC=2)C=2N=NSC=2)N(CC)C=1CC1=CC=CC=C1 XHXDJDGNDJOWIH-UHFFFAOYSA-N 0.000 claims 1
FYQXJPPEYPXUJN-UHFFFAOYSA-N 4-[4-[[4-ethyl-5-(2-methylsulfanylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 FYQXJPPEYPXUJN-UHFFFAOYSA-N 0.000 claims 1
GTNQPQNVLRLTCQ-UHFFFAOYSA-N 4-[4-[[4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 GTNQPQNVLRLTCQ-UHFFFAOYSA-N 0.000 claims 1
KQDRKEZEXONQKL-UHFFFAOYSA-N 4-[4-[[4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 KQDRKEZEXONQKL-UHFFFAOYSA-N 0.000 claims 1
RTHARHUIYLMPDW-UHFFFAOYSA-N 4-[4-[[4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 RTHARHUIYLMPDW-UHFFFAOYSA-N 0.000 claims 1
GMJPFABIFVCPAX-UHFFFAOYSA-N 4-[4-[[4-methyl-5-(5-methylthiophen-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound S1C(C)=CC=C1C(N1C)=NN=C1SCC1=CC=C(C=2N=NSC=2)C=C1 GMJPFABIFVCPAX-UHFFFAOYSA-N 0.000 claims 1
BGBGYKQVRVOOJF-UHFFFAOYSA-N 4-[4-[[5-(1,3-benzodioxol-5-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 BGBGYKQVRVOOJF-UHFFFAOYSA-N 0.000 claims 1
LFJYRICFGCWGLX-UHFFFAOYSA-N 4-[4-[[5-(1-benzothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 LFJYRICFGCWGLX-UHFFFAOYSA-N 0.000 claims 1
XCUPFZHLHYDCNX-UHFFFAOYSA-N 4-[4-[[5-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 XCUPFZHLHYDCNX-UHFFFAOYSA-N 0.000 claims 1
BMMUAFBXVFHGPP-UHFFFAOYSA-N 4-[4-[[5-(4-chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 BMMUAFBXVFHGPP-UHFFFAOYSA-N 0.000 claims 1
RYWLDCMGGNRWLC-UHFFFAOYSA-N 4-[4-[[5-(5-chlorothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]thiadiazole Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC(C=C1)=CC=C1C1=CSN=N1 RYWLDCMGGNRWLC-UHFFFAOYSA-N 0.000 claims 1
ATRROVFKDWDIKQ-UHFFFAOYSA-N 4-[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O ATRROVFKDWDIKQ-UHFFFAOYSA-N 0.000 claims 1
OUYCXSAGTHGGJJ-UHFFFAOYSA-N 4-[4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 OUYCXSAGTHGGJJ-UHFFFAOYSA-N 0.000 claims 1
MXRDZHAYTHVKIY-UHFFFAOYSA-N 4-[4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-n,n-dimethylaniline Chemical compound N=1N=C(C=2C=CC(=CC=2)N(C)C)N(CC)C=1SCC1=CC=C(OC)C=C1 MXRDZHAYTHVKIY-UHFFFAOYSA-N 0.000 claims 1
GLVAEIXDDKOVRD-UHFFFAOYSA-N 4-[4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 GLVAEIXDDKOVRD-UHFFFAOYSA-N 0.000 claims 1
APUOSMIWAIFJBP-UHFFFAOYSA-N 4-[4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 APUOSMIWAIFJBP-UHFFFAOYSA-N 0.000 claims 1
FZUQSOVFDFUGLN-UHFFFAOYSA-N 4-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 FZUQSOVFDFUGLN-UHFFFAOYSA-N 0.000 claims 1
IOZSWHQHVPBNGE-UHFFFAOYSA-N 4-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 IOZSWHQHVPBNGE-UHFFFAOYSA-N 0.000 claims 1
ONPJCEYLMNBNRD-UHFFFAOYSA-N 4-[4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-n,n-dimethylaniline Chemical compound N=1N=C(C=2C=CC(=CC=2)N(C)C)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 ONPJCEYLMNBNRD-UHFFFAOYSA-N 0.000 claims 1
PYUIMMDIINJDHK-UHFFFAOYSA-N 4-[4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 PYUIMMDIINJDHK-UHFFFAOYSA-N 0.000 claims 1
VLMPNOBPFDZHGP-UHFFFAOYSA-N 4-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-n,n-dimethylaniline Chemical compound N=1N=C(C=2C=CC(=CC=2)N(C)C)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O VLMPNOBPFDZHGP-UHFFFAOYSA-N 0.000 claims 1
ZXIMFLGCCZZJPK-UHFFFAOYSA-N 4-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O ZXIMFLGCCZZJPK-UHFFFAOYSA-N 0.000 claims 1
LCAHTRHNNGPQBQ-UHFFFAOYSA-N 4-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 LCAHTRHNNGPQBQ-UHFFFAOYSA-N 0.000 claims 1
MZXMJRXLRDGTEK-UHFFFAOYSA-N 4-[4-ethyl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 MZXMJRXLRDGTEK-UHFFFAOYSA-N 0.000 claims 1
QGMRICCOCAZISZ-UHFFFAOYSA-N 4-[5-(6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepin-3-yl)pyridin-2-yl]morpholine Chemical compound C1COCCN1C1=CC=C(C=2N3CCCCCC3=NN=2)C=N1 QGMRICCOCAZISZ-UHFFFAOYSA-N 0.000 claims 1
IDNWCNHKUOMRRB-UHFFFAOYSA-N 4-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]-n,n-dimethylaniline Chemical compound N=1N=C(C=2C=CC(=CC=2)N(C)C)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl IDNWCNHKUOMRRB-UHFFFAOYSA-N 0.000 claims 1
YMHASMKSPODPMT-UHFFFAOYSA-N 4-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl YMHASMKSPODPMT-UHFFFAOYSA-N 0.000 claims 1
HLZVIUZAYFVDSA-UHFFFAOYSA-N 4-[5-[(2,6-dichlorophenyl)methylsulfanyl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]pyridine Chemical compound ClC1=CC=CC(Cl)=C1CSC(N1CC=2OC=CC=2)=NN=C1C1=CC=NC=C1 HLZVIUZAYFVDSA-UHFFFAOYSA-N 0.000 claims 1
ZHOYYBOHVOLBKW-UHFFFAOYSA-N 4-[5-[(3,5-dimethoxyphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC(OC)=CC(OC)=C1 ZHOYYBOHVOLBKW-UHFFFAOYSA-N 0.000 claims 1
KYXIMLKSQIMTGY-UHFFFAOYSA-N 4-[5-[(4-bromophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 KYXIMLKSQIMTGY-UHFFFAOYSA-N 0.000 claims 1
RLTJGWZANMGDJP-UHFFFAOYSA-N 4-[5-[(4-bromophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC=C(Br)C=C1 RLTJGWZANMGDJP-UHFFFAOYSA-N 0.000 claims 1
UNCSHCIIADOOCH-UHFFFAOYSA-N 4-[5-[(4-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(Cl)C=C1 UNCSHCIIADOOCH-UHFFFAOYSA-N 0.000 claims 1
OUFPCLUUQYRIQE-UHFFFAOYSA-N 4-[5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]aniline Chemical compound N=1N=C(C=2C=CC(N)=CC=2)N(C)C=1SCC1=CC=C(Cl)C=C1 OUFPCLUUQYRIQE-UHFFFAOYSA-N 0.000 claims 1
MPBSWWMCXWZSNR-UHFFFAOYSA-N 4-[5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]phenol Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(C)C=1SCC1=CC=C(Cl)C=C1 MPBSWWMCXWZSNR-UHFFFAOYSA-N 0.000 claims 1
PIASNQAKAMXOQL-UHFFFAOYSA-N 4-[5-[(4-tert-butylphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC=C(C(C)(C)C)C=C1 PIASNQAKAMXOQL-UHFFFAOYSA-N 0.000 claims 1
BCHPDWOONRTFDM-UHFFFAOYSA-N 4-[5-[(4-tert-butylphenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]pyridine Chemical compound N=1N=C(C=2C=CN=CC=2)N(C)C=1SCC1=CC=C(C(C)(C)C)C=C1 BCHPDWOONRTFDM-UHFFFAOYSA-N 0.000 claims 1
PJUFBQTZPMLXQD-UHFFFAOYSA-N 4-[5-[(6-chloro-1,3-benzodioxol-5-yl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]phenol Chemical compound CCN1C(SCC=2C(=CC=3OCOC=3C=2)Cl)=NN=C1C1=CC=C(O)C=C1 PJUFBQTZPMLXQD-UHFFFAOYSA-N 0.000 claims 1
KHAXDXLAUXSRCH-UHFFFAOYSA-N 4-[5-[2-(2-methoxyphenoxy)ethylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]aniline Chemical compound COC1=CC=CC=C1OCCSC(N1C)=NN=C1C1=CC=C(N)C=C1 KHAXDXLAUXSRCH-UHFFFAOYSA-N 0.000 claims 1
NOABKXNZQOTPJK-UHFFFAOYSA-N 4-[[4-ethyl-5-(1h-indol-3-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=C(C#N)C=C1 NOABKXNZQOTPJK-UHFFFAOYSA-N 0.000 claims 1
RVZMUDIAQWZHRG-UHFFFAOYSA-N 4-[[4-ethyl-5-(3-hydroxypropyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=C(C#N)C=C1 RVZMUDIAQWZHRG-UHFFFAOYSA-N 0.000 claims 1
RHKMTTDMTOZSBQ-UHFFFAOYSA-N 4-[[4-ethyl-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 RHKMTTDMTOZSBQ-UHFFFAOYSA-N 0.000 claims 1
SBBLEUVFEHJPGB-UHFFFAOYSA-N 4-[[4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 SBBLEUVFEHJPGB-UHFFFAOYSA-N 0.000 claims 1
UPHYHHLLAZJYTM-UHFFFAOYSA-N 4-[[4-ethyl-5-(4-phenylthiadiazol-5-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C2=C(N=NS2)C=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 UPHYHHLLAZJYTM-UHFFFAOYSA-N 0.000 claims 1
JLIZTFPVKKSYSJ-UHFFFAOYSA-N 4-[[4-ethyl-5-(4-piperidin-1-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=CC(=CC=2)S(=O)(=O)N2CCCCC2)N(CC)C=1SCC1=CC=C(C#N)C=C1 JLIZTFPVKKSYSJ-UHFFFAOYSA-N 0.000 claims 1
JSZBFKGBRBXERT-UHFFFAOYSA-N 4-[[4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 JSZBFKGBRBXERT-UHFFFAOYSA-N 0.000 claims 1
SYAXWOJTDAOUJC-UHFFFAOYSA-N 4-[[5-(1,3-benzodioxol-5-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 SYAXWOJTDAOUJC-UHFFFAOYSA-N 0.000 claims 1
VLPOJEOUSGIMCG-UHFFFAOYSA-N 4-[[5-(1-benzothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 VLPOJEOUSGIMCG-UHFFFAOYSA-N 0.000 claims 1
GTXTWGFKYJZBJD-UHFFFAOYSA-N 4-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC1=CC=C(C#N)C=C1 GTXTWGFKYJZBJD-UHFFFAOYSA-N 0.000 claims 1
WBSQKBVCMIVFIM-UHFFFAOYSA-N 4-[[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]methyl]benzonitrile Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1C=C2)=CC=C1N2CC1=CC=C(C#N)C=C1 WBSQKBVCMIVFIM-UHFFFAOYSA-N 0.000 claims 1
AZDXADGHORPDIT-UHFFFAOYSA-N 4-[[5-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=C(C#N)C=C1 AZDXADGHORPDIT-UHFFFAOYSA-N 0.000 claims 1
KRBJECGCLMEFFZ-UHFFFAOYSA-N 4-[[5-(4-chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 KRBJECGCLMEFFZ-UHFFFAOYSA-N 0.000 claims 1
NSBMTWPTPAUAKE-UHFFFAOYSA-N 4-[[5-(5-chlorothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C#N)C=C1 NSBMTWPTPAUAKE-UHFFFAOYSA-N 0.000 claims 1
WWIXCWSAVMUZRS-UHFFFAOYSA-N 4-[[5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzonitrile Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(C#N)C=C1 WWIXCWSAVMUZRS-UHFFFAOYSA-N 0.000 claims 1
VBQURISEJZGIJF-UHFFFAOYSA-N 4-amino-n-cyclohexyl-n-methylbenzamide Chemical compound C=1C=C(N)C=CC=1C(=O)N(C)C1CCCCC1 VBQURISEJZGIJF-UHFFFAOYSA-N 0.000 claims 1
AUTMXVSOOABCRA-UHFFFAOYSA-N 4-benzyl-3,5-bis(4-methylphenyl)-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1C(N1CC=2C=CC=CC=2)=NN=C1C1=CC=C(C)C=C1 AUTMXVSOOABCRA-UHFFFAOYSA-N 0.000 claims 1
OMJCGOMLYOLCQK-UHFFFAOYSA-N 4-benzyl-3-[(4-fluoronaphthalen-1-yl)methylsulfanyl]-5-phenyl-1,2,4-triazole Chemical compound C12=CC=CC=C2C(F)=CC=C1CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CC=C1 OMJCGOMLYOLCQK-UHFFFAOYSA-N 0.000 claims 1
XILSEGNRZUYELB-UHFFFAOYSA-N 4-benzyl-3-cyclohexyl-1h-1,2,4-triazole-5-thione Chemical compound C=1C=CC=CC=1CN1C(=S)NN=C1C1CCCCC1 XILSEGNRZUYELB-UHFFFAOYSA-N 0.000 claims 1
UZZVSLCBVYKWJP-UHFFFAOYSA-N 4-butyl-3-(3-chlorophenyl)-1h-1,2,4-triazole-5-thione Chemical compound CCCCN1C(S)=NN=C1C1=CC=CC(Cl)=C1 UZZVSLCBVYKWJP-UHFFFAOYSA-N 0.000 claims 1
DSEGTCSERAIXAT-UHFFFAOYSA-N 4-chloro-n-cyclohexyl-n-ethyl-3-nitrobenzamide Chemical compound C=1C=C(Cl)C([N+]([O-])=O)=CC=1C(=O)N(CC)C1CCCCC1 DSEGTCSERAIXAT-UHFFFAOYSA-N 0.000 claims 1
125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 1
ODZPQBCHGIRTHD-UHFFFAOYSA-N 4-cyclopropyl-3-(2-methoxyethylsulfanyl)-5-(2-methoxyphenyl)-1,2,4-triazole Chemical compound C1CC1N1C(SCCOC)=NN=C1C1=CC=CC=C1OC ODZPQBCHGIRTHD-UHFFFAOYSA-N 0.000 claims 1
AOUOKAHXWSRPEE-UHFFFAOYSA-N 4-cyclopropyl-3-(2-methoxyethylsulfanyl)-5-thiophen-2-yl-1,2,4-triazole Chemical compound C1CC1N1C(SCCOC)=NN=C1C1=CC=CS1 AOUOKAHXWSRPEE-UHFFFAOYSA-N 0.000 claims 1
CTPUECQCTXSBMM-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O CTPUECQCTXSBMM-UHFFFAOYSA-N 0.000 claims 1
REBPSPZTHZRFQR-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=C(C)C=C1 REBPSPZTHZRFQR-UHFFFAOYSA-N 0.000 claims 1
ZAFFZYIXKBDCHO-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 ZAFFZYIXKBDCHO-UHFFFAOYSA-N 0.000 claims 1
GSIDREWZVJVEIF-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 GSIDREWZVJVEIF-UHFFFAOYSA-N 0.000 claims 1
ARBASIDAVPCJHA-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 ARBASIDAVPCJHA-UHFFFAOYSA-N 0.000 claims 1
GXPGRBWFHBQUCF-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O GXPGRBWFHBQUCF-UHFFFAOYSA-N 0.000 claims 1
XOMILXVIANENOJ-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 XOMILXVIANENOJ-UHFFFAOYSA-N 0.000 claims 1
HEFFRPZKFLKGKN-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 HEFFRPZKFLKGKN-UHFFFAOYSA-N 0.000 claims 1
TXVIAEAZRHFPSD-UHFFFAOYSA-N 4-ethyl-3-(2-methoxyphenyl)-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 TXVIAEAZRHFPSD-UHFFFAOYSA-N 0.000 claims 1
FSZZUCJWZZZGGB-UHFFFAOYSA-N 4-ethyl-3-(2-phenoxyphenyl)-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 FSZZUCJWZZZGGB-UHFFFAOYSA-N 0.000 claims 1
FGNZSUZIPBNIIH-UHFFFAOYSA-N 4-ethyl-3-(2-phenoxyphenyl)-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 FGNZSUZIPBNIIH-UHFFFAOYSA-N 0.000 claims 1
PQEYJSXHIFZQHI-UHFFFAOYSA-N 4-ethyl-3-(2-phenoxyphenyl)-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 PQEYJSXHIFZQHI-UHFFFAOYSA-N 0.000 claims 1
CKBYENMOKAIAPX-UHFFFAOYSA-N 4-ethyl-3-(4-methoxyphenyl)-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O CKBYENMOKAIAPX-UHFFFAOYSA-N 0.000 claims 1
XESYVWOXHFYGJS-UHFFFAOYSA-N 4-ethyl-3-(4-methoxyphenyl)-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 XESYVWOXHFYGJS-UHFFFAOYSA-N 0.000 claims 1
JNQQUNKQHQTCCT-UHFFFAOYSA-N 4-ethyl-3-(4-methoxyphenyl)-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 JNQQUNKQHQTCCT-UHFFFAOYSA-N 0.000 claims 1
WYYGCPZFPLRJLX-UHFFFAOYSA-N 4-ethyl-3-(4-methoxyphenyl)-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 WYYGCPZFPLRJLX-UHFFFAOYSA-N 0.000 claims 1
NCBBFMBQKVBQMZ-UHFFFAOYSA-N 4-ethyl-3-(4-methoxyphenyl)-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 NCBBFMBQKVBQMZ-UHFFFAOYSA-N 0.000 claims 1
WNHUSXQMCUNCQY-UHFFFAOYSA-N 4-ethyl-3-(4-methoxyphenyl)-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 WNHUSXQMCUNCQY-UHFFFAOYSA-N 0.000 claims 1
VQIFYRTWGIWQEE-UHFFFAOYSA-N 4-ethyl-3-(5-methylthiophen-2-yl)-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O VQIFYRTWGIWQEE-UHFFFAOYSA-N 0.000 claims 1
ARIBLEKFHQWSJO-UHFFFAOYSA-N 4-ethyl-3-(5-methylthiophen-2-yl)-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 ARIBLEKFHQWSJO-UHFFFAOYSA-N 0.000 claims 1
ODGMVQORVYJCPO-UHFFFAOYSA-N 4-ethyl-3-(5-methylthiophen-2-yl)-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 ODGMVQORVYJCPO-UHFFFAOYSA-N 0.000 claims 1
NJYUCKYVUWCUPX-UHFFFAOYSA-N 4-ethyl-3-(5-methylthiophen-2-yl)-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 NJYUCKYVUWCUPX-UHFFFAOYSA-N 0.000 claims 1
PORJHQAGLXRDTL-UHFFFAOYSA-N 4-ethyl-3-(5-methylthiophen-2-yl)-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 PORJHQAGLXRDTL-UHFFFAOYSA-N 0.000 claims 1
FCWOFTAAJAMCSV-UHFFFAOYSA-N 4-ethyl-3-[(2-nitrophenyl)methylsulfanyl]-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O FCWOFTAAJAMCSV-UHFFFAOYSA-N 0.000 claims 1
IGCCKFJXTSOYOC-UHFFFAOYSA-N 4-ethyl-3-[(2-nitrophenyl)methylsulfanyl]-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O IGCCKFJXTSOYOC-UHFFFAOYSA-N 0.000 claims 1
ZTEWMOVFUTVCQW-UHFFFAOYSA-N 4-ethyl-3-[(3-nitrophenyl)methylsulfanyl]-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 ZTEWMOVFUTVCQW-UHFFFAOYSA-N 0.000 claims 1
XIBOJQFSTHLSIN-UHFFFAOYSA-N 4-ethyl-3-[(4-methoxyphenyl)methylsulfanyl]-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 XIBOJQFSTHLSIN-UHFFFAOYSA-N 0.000 claims 1
LRPBBFNCFVEOPV-UHFFFAOYSA-N 4-ethyl-3-[(4-methoxyphenyl)methylsulfanyl]-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 LRPBBFNCFVEOPV-UHFFFAOYSA-N 0.000 claims 1
ULZOWEVPJIIBKR-UHFFFAOYSA-N 4-ethyl-3-[(4-methoxyphenyl)methylsulfanyl]-5-naphthalen-1-yl-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 ULZOWEVPJIIBKR-UHFFFAOYSA-N 0.000 claims 1
WNJFIVGBJDQDSS-UHFFFAOYSA-N 4-ethyl-3-[(4-methoxyphenyl)methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 WNJFIVGBJDQDSS-UHFFFAOYSA-N 0.000 claims 1
IBBGLODAOHHFMO-UHFFFAOYSA-N 4-ethyl-3-[(4-methylphenyl)methylsulfanyl]-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 IBBGLODAOHHFMO-UHFFFAOYSA-N 0.000 claims 1
UHKOIOLBKJKVQD-UHFFFAOYSA-N 4-ethyl-3-[(4-methylphenyl)methylsulfanyl]-5-(4-nitrophenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1SCC1=CC=C(C)C=C1 UHKOIOLBKJKVQD-UHFFFAOYSA-N 0.000 claims 1
NHTLTXJUEMHAMF-UHFFFAOYSA-N 4-ethyl-3-[(4-methylphenyl)methylsulfanyl]-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 NHTLTXJUEMHAMF-UHFFFAOYSA-N 0.000 claims 1
AOSMUGPYCRQJDB-UHFFFAOYSA-N 4-ethyl-3-[(4-methylphenyl)methylsulfanyl]-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=C(C)C=C1 AOSMUGPYCRQJDB-UHFFFAOYSA-N 0.000 claims 1
JDORSLUONBPTFH-UHFFFAOYSA-N 4-ethyl-3-[(4-methylphenyl)methylsulfanyl]-5-naphthalen-1-yl-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 JDORSLUONBPTFH-UHFFFAOYSA-N 0.000 claims 1
FVIGYVNFOJVLCQ-UHFFFAOYSA-N 4-ethyl-3-[(4-methylphenyl)methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(C)C=C1 FVIGYVNFOJVLCQ-UHFFFAOYSA-N 0.000 claims 1
PMHYXCRFZGYKLU-UHFFFAOYSA-N 4-ethyl-3-[(4-methylsulfonylphenyl)methylsulfanyl]-5-(2-phenoxyphenyl)-1,2,4-triazole Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 PMHYXCRFZGYKLU-UHFFFAOYSA-N 0.000 claims 1
ZDNNSVQKWQFUCM-UHFFFAOYSA-N 4-ethyl-3-[(4-methylsulfonylphenyl)methylsulfanyl]-5-(5-methylthiophen-2-yl)-1,2,4-triazole Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 ZDNNSVQKWQFUCM-UHFFFAOYSA-N 0.000 claims 1
OIFDZFISYKRABH-UHFFFAOYSA-N 4-ethyl-3-[(4-methylsulfonylphenyl)methylsulfanyl]-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 OIFDZFISYKRABH-UHFFFAOYSA-N 0.000 claims 1
PBLTXWMLGMDBTA-UHFFFAOYSA-N 4-ethyl-3-[(4-methylsulfonylphenyl)methylsulfanyl]-5-naphthalen-1-yl-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 PBLTXWMLGMDBTA-UHFFFAOYSA-N 0.000 claims 1
HAZPMUOTNFHHPN-UHFFFAOYSA-N 4-ethyl-3-[(4-methylsulfonylphenyl)methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 HAZPMUOTNFHHPN-UHFFFAOYSA-N 0.000 claims 1
ZZYCPGBATIITLA-UHFFFAOYSA-N 4-ethyl-3-[(4-nitrophenyl)methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 ZZYCPGBATIITLA-UHFFFAOYSA-N 0.000 claims 1
FZOXXTPVJJDGQB-UHFFFAOYSA-N 4-ethyl-3-[(4-phenylmethoxyphenyl)methylsulfanyl]-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 FZOXXTPVJJDGQB-UHFFFAOYSA-N 0.000 claims 1
NPOYIHYSCDSVPU-UHFFFAOYSA-N 4-ethyl-3-[(5-methyl-2-nitrophenyl)methylsulfanyl]-5-naphthalen-1-yl-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O NPOYIHYSCDSVPU-UHFFFAOYSA-N 0.000 claims 1
ONTBBQIOQCFBHH-UHFFFAOYSA-N 4-ethyl-3-[(5-methyl-2-nitrophenyl)methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O ONTBBQIOQCFBHH-UHFFFAOYSA-N 0.000 claims 1
HZGSVZSAEVNTCU-UHFFFAOYSA-N 4-ethyl-3-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 HZGSVZSAEVNTCU-UHFFFAOYSA-N 0.000 claims 1
WQMYUIWCKGPMOD-UHFFFAOYSA-N 4-ethyl-3-naphthalen-1-yl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 WQMYUIWCKGPMOD-UHFFFAOYSA-N 0.000 claims 1
WPMNOAFWIAOCDI-UHFFFAOYSA-N 4-ethyl-3-naphthalen-1-yl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 WPMNOAFWIAOCDI-UHFFFAOYSA-N 0.000 claims 1
AFSZDIIOIYCDPL-UHFFFAOYSA-N 4-ethyl-3-naphthalen-1-yl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 AFSZDIIOIYCDPL-UHFFFAOYSA-N 0.000 claims 1
WVOCXAPOSDDJDD-UHFFFAOYSA-N 4-ethyl-3-thiophen-2-yl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 WVOCXAPOSDDJDD-UHFFFAOYSA-N 0.000 claims 1
MODKOYXFRWMZAF-UHFFFAOYSA-N 4-ethyl-3-thiophen-2-yl-5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazole Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(C(F)(F)F)C=C1 MODKOYXFRWMZAF-UHFFFAOYSA-N 0.000 claims 1
JGFVAUUDLCHKQI-UHFFFAOYSA-N 4-hydroxy-n-[(4-hydroxyphenyl)methyl]-n-(2-methylpropyl)benzamide Chemical compound C=1C=C(O)C=CC=1C(=O)N(CC(C)C)CC1=CC=C(O)C=C1 JGFVAUUDLCHKQI-UHFFFAOYSA-N 0.000 claims 1
ZDTDRQKMYDIBCL-UHFFFAOYSA-N 4-methyl-3-(4-methylphenyl)-5-(2-phenylethylsulfanyl)-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1C(N1C)=NN=C1SCCC1=CC=CC=C1 ZDTDRQKMYDIBCL-UHFFFAOYSA-N 0.000 claims 1
VJTNNIOWMBZUGK-UHFFFAOYSA-N 4-methyl-3-[(2-methylphenyl)methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole Chemical compound CC1=CC=CC=C1CSC(N1C)=NN=C1C1=CC=CS1 VJTNNIOWMBZUGK-UHFFFAOYSA-N 0.000 claims 1
SFMXKNDDMRQDNZ-UHFFFAOYSA-N 4-methyl-3-[(4-methylphenyl)methylsulfanyl]-5-[3-(trifluoromethyl)phenyl]-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1CSC(N1C)=NN=C1C1=CC=CC(C(F)(F)F)=C1 SFMXKNDDMRQDNZ-UHFFFAOYSA-N 0.000 claims 1
YSWSUZCEBFYVND-UHFFFAOYSA-N 4-methyl-3-[(4-nitrophenyl)methylsulfanyl]-5-phenyl-1,2,4-triazole Chemical compound N=1N=C(C=2C=CC=CC=2)N(C)C=1SCC1=CC=C([N+]([O-])=O)C=C1 YSWSUZCEBFYVND-UHFFFAOYSA-N 0.000 claims 1
HVACUGYQMUTBDJ-UHFFFAOYSA-N 4-methyl-3-[3-[(4-methylphenyl)methoxy]thiophen-2-yl]-5-methylsulfanyl-1,2,4-triazole Chemical compound CN1C(SC)=NN=C1C1=C(OCC=2C=CC(C)=CC=2)C=CS1 HVACUGYQMUTBDJ-UHFFFAOYSA-N 0.000 claims 1
JGPSODNQURDKFU-UHFFFAOYSA-N 4-methyl-3-[3-[[3-(trifluoromethyl)phenyl]methoxy]thiophen-2-yl]-1h-1,2,4-triazole-5-thione Chemical compound N1C(=S)N(C)C(C2=C(C=CS2)OCC=2C=C(C=CC=2)C(F)(F)F)=N1 JGPSODNQURDKFU-UHFFFAOYSA-N 0.000 claims 1
BTMDFZSYLBTEOT-UHFFFAOYSA-N 4-methyl-3-methylsulfanyl-5-[3-[[3-(trifluoromethyl)phenyl]methoxy]thiophen-2-yl]-1,2,4-triazole Chemical compound CN1C(SC)=NN=C1C1=C(OCC=2C=C(C=CC=2)C(F)(F)F)C=CS1 BTMDFZSYLBTEOT-UHFFFAOYSA-N 0.000 claims 1
IJOYYGFIORIFJG-UHFFFAOYSA-N 4-methyl-5-(4-methyl-5-prop-2-ynylsulfanyl-1,2,4-triazol-3-yl)-2-phenyl-1,3-thiazole Chemical compound CC=1N=C(C=2C=CC=CC=2)SC=1C1=NN=C(SCC#C)N1C IJOYYGFIORIFJG-UHFFFAOYSA-N 0.000 claims 1
NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims 1
UMCSDNAWBPUNIJ-UHFFFAOYSA-N 5,5-dimethyl-3-(3,4,5-trimethoxyphenyl)-6h-[1,2,4]triazolo[3,4-a]isoquinoline Chemical compound COC1=C(OC)C(OC)=CC(C=2N3C(C)(C)CC4=CC=CC=C4C3=NN=2)=C1 UMCSDNAWBPUNIJ-UHFFFAOYSA-N 0.000 claims 1
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GAPVDAUIUSONCC-UHFFFAOYSA-N 5-[(4-nitrophenyl)methylsulfanyl]-1h-1,2,4-triazole Chemical compound C1=CC([N+](=O)[O-])=CC=C1CSC1=NC=NN1 GAPVDAUIUSONCC-UHFFFAOYSA-N 0.000 claims 1
JUAIRLNRTHXWGG-UHFFFAOYSA-N 5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1h-1,2,4-triazole Chemical compound FC(F)(F)C1=C(C=2NN=CN=2)C=NN1C1=CC=CC=C1 JUAIRLNRTHXWGG-UHFFFAOYSA-N 0.000 claims 1
GMCRTOFQUQRORH-UHFFFAOYSA-N 5-[4-ethyl-5-[(2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-phenylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C=2C=CC=CC=2)N(CC)C=1SCC1=CC=CC=C1[N+]([O-])=O GMCRTOFQUQRORH-UHFFFAOYSA-N 0.000 claims 1
WIYDGCODYJENAJ-UHFFFAOYSA-N 5-[4-ethyl-5-[(3-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-methylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C)N(CC)C=1SCC1=CC=CC([N+]([O-])=O)=C1 WIYDGCODYJENAJ-UHFFFAOYSA-N 0.000 claims 1
YBSJPOOWFXUMQU-UHFFFAOYSA-N 5-[4-ethyl-5-[(4-methoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-phenylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(OC)C=C1 YBSJPOOWFXUMQU-UHFFFAOYSA-N 0.000 claims 1
PIYLRUHJJOWQJZ-UHFFFAOYSA-N 5-[4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-methylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C)N(CC)C=1SCC1=CC=C(C)C=C1 PIYLRUHJJOWQJZ-UHFFFAOYSA-N 0.000 claims 1
WIYXDBSTARSLOO-UHFFFAOYSA-N 5-[4-ethyl-5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-phenylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(S(C)(=O)=O)C=C1 WIYXDBSTARSLOO-UHFFFAOYSA-N 0.000 claims 1
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PTZFSCPCFICDKE-UHFFFAOYSA-N 5-[4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-phenylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C=2C=CC=CC=2)N(CC)C=1SCC1=CC=C([N+]([O-])=O)C=C1 PTZFSCPCFICDKE-UHFFFAOYSA-N 0.000 claims 1
KNLYROCUENWUNH-UHFFFAOYSA-N 5-[4-ethyl-5-[(4-phenylmethoxyphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-methylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C)N(CC)C=1SCC(C=C1)=CC=C1OCC1=CC=CC=C1 KNLYROCUENWUNH-UHFFFAOYSA-N 0.000 claims 1
HELOFIMEKFGUFT-UHFFFAOYSA-N 5-[4-ethyl-5-[(5-methyl-2-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-4-methylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C)N(CC)C=1SCC1=CC(C)=CC=C1[N+]([O-])=O HELOFIMEKFGUFT-UHFFFAOYSA-N 0.000 claims 1
MPDOWSIGCCTHRK-UHFFFAOYSA-N 5-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]-4-methylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 MPDOWSIGCCTHRK-UHFFFAOYSA-N 0.000 claims 1
WLVFKQMKARUGCQ-UHFFFAOYSA-N 5-[4-ethyl-5-[[3-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]-4-phenylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C=2C=CC=CC=2)N(CC)C=1SCC1=CC=CC(OC(F)(F)F)=C1 WLVFKQMKARUGCQ-UHFFFAOYSA-N 0.000 claims 1
AGRVLUMFTPUVSP-UHFFFAOYSA-N 5-[4-ethyl-5-[[4-(trifluoromethoxy)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]-4-phenylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(OC(F)(F)F)C=C1 AGRVLUMFTPUVSP-UHFFFAOYSA-N 0.000 claims 1
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PLEFNGIASSCQRD-UHFFFAOYSA-N 5-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]-4-methylthiadiazole Chemical compound N=1N=C(C2=C(N=NS2)C)N(CC)C=1SCC1=CC=C(Cl)C=C1Cl PLEFNGIASSCQRD-UHFFFAOYSA-N 0.000 claims 1
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CTOZKWIMRXNQGU-UHFFFAOYSA-N chembl1523672 Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(C)C=1SCC(=O)C1=CC=CC=C1 CTOZKWIMRXNQGU-UHFFFAOYSA-N 0.000 claims 1
RFQYUDBIZBPLKN-UHFFFAOYSA-N chembl1536616 Chemical compound C1=CC(O)=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC(=O)C1=CC=CC=C1 RFQYUDBIZBPLKN-UHFFFAOYSA-N 0.000 claims 1
AMUMENYCCWALTN-UHFFFAOYSA-N chembl1577995 Chemical compound OC1=CC=CC=C1C1=NN=C(SCC#N)N1CCC1=CC=CC=C1 AMUMENYCCWALTN-UHFFFAOYSA-N 0.000 claims 1
230000006835 compression Effects 0.000 claims 1
238000007906 compression Methods 0.000 claims 1
DOHBALJMFBMLDS-UHFFFAOYSA-N cyclohexyl 2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetate Chemical compound C1CCCCC1OC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 DOHBALJMFBMLDS-UHFFFAOYSA-N 0.000 claims 1
GDYPXATYYNJLNJ-UHFFFAOYSA-N cyclohexyl 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetate Chemical compound N=1N=C(SCC(=O)OC2CCCCC2)N(C)C=1CC1=CC=CC=C1 GDYPXATYYNJLNJ-UHFFFAOYSA-N 0.000 claims 1
XKVSTBWZIGVECM-UHFFFAOYSA-N cyclohexyl 2-[[4-(furan-2-ylmethyl)-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound C1=CC(O)=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC(=O)OC1CCCCC1 XKVSTBWZIGVECM-UHFFFAOYSA-N 0.000 claims 1
SXDVTPWMORKRBI-UHFFFAOYSA-N cyclohexyl 2-[[4-ethyl-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC(=O)OC1CCCCC1 SXDVTPWMORKRBI-UHFFFAOYSA-N 0.000 claims 1
OEEDQEZCWMYAJS-UHFFFAOYSA-N cyclohexyl 2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound N=1N=C(SCC(=O)OC2CCCCC2)N(CC)C=1CNC1=CC=C(F)C=C1 OEEDQEZCWMYAJS-UHFFFAOYSA-N 0.000 claims 1
MUAQWJFXTAODNQ-UHFFFAOYSA-N cyclohexyl 2-[[5-(4-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound N=1N=C(C=2C=CC(Br)=CC=2)N(C)C=1SCC(=O)OC1CCCCC1 MUAQWJFXTAODNQ-UHFFFAOYSA-N 0.000 claims 1
QKPVMEAYJPEUBD-UHFFFAOYSA-N cyclohexyl 2-[[5-[(2,4-dimethylanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound N=1N=C(SCC(=O)OC2CCCCC2)N(CC)C=1CNC1=CC=C(C)C=C1C QKPVMEAYJPEUBD-UHFFFAOYSA-N 0.000 claims 1
APQWWESOSGWSNQ-UHFFFAOYSA-N cyclohexyl 2-[[5-[(2-chloroanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound N=1N=C(SCC(=O)OC2CCCCC2)N(CC)C=1CNC1=CC=CC=C1Cl APQWWESOSGWSNQ-UHFFFAOYSA-N 0.000 claims 1
MUAVJQMZQZZVSX-UHFFFAOYSA-N cyclohexyl 2-[[5-[(3-chloro-4-methylanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound N=1N=C(SCC(=O)OC2CCCCC2)N(CC)C=1CNC1=CC=C(C)C(Cl)=C1 MUAVJQMZQZZVSX-UHFFFAOYSA-N 0.000 claims 1
WJVDRVKZRSDMSC-UHFFFAOYSA-N cyclohexyl 2-[[5-[(4-chloroanilino)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound N=1N=C(SCC(=O)OC2CCCCC2)N(CC)C=1CNC1=CC=C(Cl)C=C1 WJVDRVKZRSDMSC-UHFFFAOYSA-N 0.000 claims 1
208000030172 endocrine system disease Diseases 0.000 claims 1
CDBCPHKJBMRFHR-UHFFFAOYSA-N ethyl 2-[(4-benzyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetate Chemical compound C=1C=CC=CC=1CN1C(SCC(=O)OCC)=NN=C1C1=CC=CC=C1 CDBCPHKJBMRFHR-UHFFFAOYSA-N 0.000 claims 1
VRMSQWSZMZMFFT-UHFFFAOYSA-N ethyl 2-[6-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]acetate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2C=CN(CC(=O)OCC)C2=C1 VRMSQWSZMZMFFT-UHFFFAOYSA-N 0.000 claims 1
AZJBUSLFCKOROQ-UHFFFAOYSA-N ethyl 2-[[4-(2-phenylethyl)-5-pyridin-3-yl-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound C=1C=CC=CC=1CCN1C(SCC(=O)OCC)=NN=C1C1=CC=CN=C1 AZJBUSLFCKOROQ-UHFFFAOYSA-N 0.000 claims 1
RWNCHDWXPXMQKN-UHFFFAOYSA-N ethyl 2-[[4-benzyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound C=1C=CC=CC=1CN1C(SCC(=O)OCC)=NN=C1C1=CC=C(OC)C=C1 RWNCHDWXPXMQKN-UHFFFAOYSA-N 0.000 claims 1
MVQVPGRPNVSFJT-UHFFFAOYSA-N ethyl 2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate Chemical compound CCN1C(SCC(=O)OCC)=NN=C1C1=CC=CC=C1OC MVQVPGRPNVSFJT-UHFFFAOYSA-N 0.000 claims 1
JJLSXJUIHYRBOV-UHFFFAOYSA-N ethyl 2-amino-5-(azepane-1-carbonyl)-4-methylthiophene-3-carboxylate Chemical compound CCOC(=O)C1=C(N)SC(C(=O)N2CCCCCC2)=C1C JJLSXJUIHYRBOV-UHFFFAOYSA-N 0.000 claims 1
XUENQTYWYCCBGX-UHFFFAOYSA-N ethyl 3-[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)indol-1-yl]propanoate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2N(CCC(=O)OCC)C=CC2=C1 XUENQTYWYCCBGX-UHFFFAOYSA-N 0.000 claims 1
ZPVCURRGCDGYLA-UHFFFAOYSA-N ethyl 3-[[5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carbonyl]amino]propanoate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)NCCC(=O)OCC)C2=C1 ZPVCURRGCDGYLA-UHFFFAOYSA-N 0.000 claims 1
WDJQYZSPNXKRJE-UHFFFAOYSA-N ethyl 4-[[2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1CCCCC1 WDJQYZSPNXKRJE-UHFFFAOYSA-N 0.000 claims 1
ZUZXVUWNKNIUII-UHFFFAOYSA-N ethyl 4-[[2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br ZUZXVUWNKNIUII-UHFFFAOYSA-N 0.000 claims 1
RKEMWDBWPAAWAK-UHFFFAOYSA-N ethyl 6-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxylate Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2C(C(=O)OCC)=CNC2=C1 RKEMWDBWPAAWAK-UHFFFAOYSA-N 0.000 claims 1
208000014951 hematologic disease Diseases 0.000 claims 1
DNJFMXHTNUVNII-UHFFFAOYSA-N imidazo[2,1-b][1,3]thiazol-6-yl-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octan-7-yl)methanone Chemical compound C1C2CC(C)(C)CC1(C)CN2C(=O)C1=CN(C=CS2)C2=N1 DNJFMXHTNUVNII-UHFFFAOYSA-N 0.000 claims 1
IENZCGNHSIMFJE-UHFFFAOYSA-N indole-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2NC=CC2=C1 IENZCGNHSIMFJE-UHFFFAOYSA-N 0.000 claims 1
208000014674 injury Diseases 0.000 claims 1
230000000968 intestinal effect Effects 0.000 claims 1
210000000936 intestine Anatomy 0.000 claims 1
XVYXYBDZHBRSDJ-UHFFFAOYSA-N methyl 2-[[2-[[4-ethyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate Chemical compound N=1N=C(C=2C=C(C)C=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1C(=O)OC XVYXYBDZHBRSDJ-UHFFFAOYSA-N 0.000 claims 1
PGWMMDGZOLEYMY-UHFFFAOYSA-N methyl 2-[[2-[[4-methyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC(C)=C1 PGWMMDGZOLEYMY-UHFFFAOYSA-N 0.000 claims 1
ANQMBDBYRBFSQZ-UHFFFAOYSA-N methyl 3-[6-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-benzimidazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2NC3=CC=C(C=C3N=2)C(=O)N2C3CC(CC(C)(C)C3)(C)C2)=C1 ANQMBDBYRBFSQZ-UHFFFAOYSA-N 0.000 claims 1
DXZPXECYINTUDB-UHFFFAOYSA-N methyl 4-[(4-ethyl-5-naphthalen-1-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C3=CC=CC=C3C=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 DXZPXECYINTUDB-UHFFFAOYSA-N 0.000 claims 1
OTMTWNJAHZRMCH-UHFFFAOYSA-N methyl 4-[(4-ethyl-5-pyridin-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2N=CC=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 OTMTWNJAHZRMCH-UHFFFAOYSA-N 0.000 claims 1
PQKXWFNDCWLHCO-UHFFFAOYSA-N methyl 4-[(4-ethyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 PQKXWFNDCWLHCO-UHFFFAOYSA-N 0.000 claims 1
BJMZPFJOFOIPTC-UHFFFAOYSA-N methyl 4-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 BJMZPFJOFOIPTC-UHFFFAOYSA-N 0.000 claims 1
WEZWMAPLBZLUEG-UHFFFAOYSA-N methyl 4-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2SC=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 WEZWMAPLBZLUEG-UHFFFAOYSA-N 0.000 claims 1
WRHXNHYSDZMSOV-UHFFFAOYSA-N methyl 4-[[2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C WRHXNHYSDZMSOV-UHFFFAOYSA-N 0.000 claims 1
MQQQHWSZLZEKBK-UHFFFAOYSA-N methyl 4-[[2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=C(C(=O)OC)C=C1 MQQQHWSZLZEKBK-UHFFFAOYSA-N 0.000 claims 1
PTRXAQBPTBMLQR-UHFFFAOYSA-N methyl 4-[[2-[[5-(2-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1Br PTRXAQBPTBMLQR-UHFFFAOYSA-N 0.000 claims 1
QWEKOVAQYQYMSN-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-(2-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C(=CC=CC=2)O)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 QWEKOVAQYQYMSN-UHFFFAOYSA-N 0.000 claims 1
XJCOOCQMCVDBLZ-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 XJCOOCQMCVDBLZ-UHFFFAOYSA-N 0.000 claims 1
AYWMHTZPTFMTIK-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-(2-methylsulfanylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 AYWMHTZPTFMTIK-UHFFFAOYSA-N 0.000 claims 1
RESQYUISXLOHOX-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-(2-phenoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C(=CC=CC=2)OC=2C=CC=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 RESQYUISXLOHOX-UHFFFAOYSA-N 0.000 claims 1
YJCHGKKNQDCWIN-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-(4-hydroxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C=CC(O)=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 YJCHGKKNQDCWIN-UHFFFAOYSA-N 0.000 claims 1
WHGLCEFWBQUWMW-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 WHGLCEFWBQUWMW-UHFFFAOYSA-N 0.000 claims 1
JZNXWDJIFAVCGW-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 JZNXWDJIFAVCGW-UHFFFAOYSA-N 0.000 claims 1
WJORAEFMESMYRR-UHFFFAOYSA-N methyl 4-[[4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 WJORAEFMESMYRR-UHFFFAOYSA-N 0.000 claims 1
FNUVMUDNXXDPHH-UHFFFAOYSA-N methyl 4-[[5-(1,3-benzodioxol-5-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 FNUVMUDNXXDPHH-UHFFFAOYSA-N 0.000 claims 1
QGKZADYDXZUJFG-UHFFFAOYSA-N methyl 4-[[5-(1-benzothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 QGKZADYDXZUJFG-UHFFFAOYSA-N 0.000 claims 1
JEVWSXYOUBTXQJ-UHFFFAOYSA-N methyl 4-[[5-(3-chloro-4-methylthiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C2=C(C(C)=CS2)Cl)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 JEVWSXYOUBTXQJ-UHFFFAOYSA-N 0.000 claims 1
YFOVORSXBYVNRX-UHFFFAOYSA-N methyl 4-[[5-(4-chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 YFOVORSXBYVNRX-UHFFFAOYSA-N 0.000 claims 1
FYDNCJPPYJAAJD-UHFFFAOYSA-N methyl 4-[[5-(5-chlorothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 FYDNCJPPYJAAJD-UHFFFAOYSA-N 0.000 claims 1
FWBBMKQKFJQKIC-UHFFFAOYSA-N methyl 4-[[5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]benzoate Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(C(=O)OC)C=C1 FWBBMKQKFJQKIC-UHFFFAOYSA-N 0.000 claims 1
201000006938 muscular dystrophy Diseases 0.000 claims 1
CZZLQUVWVGDTCW-UHFFFAOYSA-N n,n-dibenzyl-1h-indole-5-carboxamide Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 CZZLQUVWVGDTCW-UHFFFAOYSA-N 0.000 claims 1
DAKYKYJUYQRPIB-UHFFFAOYSA-N n,n-dibenzyl-3,4-dichlorobenzamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(=O)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 DAKYKYJUYQRPIB-UHFFFAOYSA-N 0.000 claims 1
SPJBYXZFFMMCEN-UHFFFAOYSA-N n,n-dimethyl-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)N(C)C)C2=C1 SPJBYXZFFMMCEN-UHFFFAOYSA-N 0.000 claims 1
JCOZSOSHYHVYRW-UHFFFAOYSA-N n-(1,1-dioxothiolan-3-yl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NC1CCS(=O)(=O)C1 JCOZSOSHYHVYRW-UHFFFAOYSA-N 0.000 claims 1
WSHKKNGZOWLLMK-UHFFFAOYSA-N n-(1-adamantyl)-1-methylindole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NC1(C2)CC(C3)CC2CC3C1 WSHKKNGZOWLLMK-UHFFFAOYSA-N 0.000 claims 1
FVMFGNBRCDDCPL-UHFFFAOYSA-N n-(1-adamantyl)-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound S1C(C)=NC(C)=C1C(=O)NC1(C2)CC(C3)CC2CC3C1 FVMFGNBRCDDCPL-UHFFFAOYSA-N 0.000 claims 1
LHIGWKODECDZGV-UHFFFAOYSA-N n-(2,3-dichlorophenyl)-2-[[4-(furan-2-ylmethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC(=O)NC1=CC=CC(Cl)=C1Cl LHIGWKODECDZGV-UHFFFAOYSA-N 0.000 claims 1
WXMRRXGEYUXMNT-UHFFFAOYSA-N n-(2,3-dichlorophenyl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=CC(Cl)=C1Cl WXMRRXGEYUXMNT-UHFFFAOYSA-N 0.000 claims 1
PBYSMCNUUHINQI-UHFFFAOYSA-N n-(2,4-dimethoxyphenyl)-2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(OC)C=C1OC PBYSMCNUUHINQI-UHFFFAOYSA-N 0.000 claims 1
FBDWATZGHYXZFP-UHFFFAOYSA-N n-(2,4-dimethoxyphenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC(OC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C FBDWATZGHYXZFP-UHFFFAOYSA-N 0.000 claims 1
ZOMACASNERZBEN-UHFFFAOYSA-N n-(2,4-dimethylphenyl)-3-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)benzenesulfonamide Chemical compound CC1=CC(C)=CC=C1NS(=O)(=O)C1=CC=CC(C(=O)N2C3CC(CC(C)(C)C3)(C)C2)=C1 ZOMACASNERZBEN-UHFFFAOYSA-N 0.000 claims 1
JGFWCWGZGMGGPZ-UHFFFAOYSA-N n-(2,5-dichlorophenyl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC(Cl)=CC=C1Cl JGFWCWGZGMGGPZ-UHFFFAOYSA-N 0.000 claims 1
SEDGPWXNQMBTGZ-UHFFFAOYSA-N n-(2,6-dimethylpiperidin-1-yl)-1-methylindole-3-carboxamide Chemical compound CC1CCCC(C)N1NC(=O)C1=CN(C)C2=CC=CC=C12 SEDGPWXNQMBTGZ-UHFFFAOYSA-N 0.000 claims 1
UYCZMUAUUJYKHR-UHFFFAOYSA-N n-(2-adamantyl)-1h-indole-5-carboxamide Chemical compound C1=C2NC=CC2=CC(C(NC2C3CC4CC(C3)CC2C4)=O)=C1 UYCZMUAUUJYKHR-UHFFFAOYSA-N 0.000 claims 1
AIPDFMDSZTYMJE-UHFFFAOYSA-N n-(2-adamantyl)-1h-indole-6-carboxamide Chemical compound C1=C2C=CNC2=CC(C(NC2C3CC4CC(C3)CC2C4)=O)=C1 AIPDFMDSZTYMJE-UHFFFAOYSA-N 0.000 claims 1
NLDVEUGIRJVVJG-UHFFFAOYSA-N n-(2-bromo-4-methylphenyl)-2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C=2C=CN=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(C)C=C1Br NLDVEUGIRJVVJG-UHFFFAOYSA-N 0.000 claims 1
OUZFFRFGAXVTCJ-UHFFFAOYSA-N n-(2-bromo-4-methylphenyl)-2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound BrC1=CC(C)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1 OUZFFRFGAXVTCJ-UHFFFAOYSA-N 0.000 claims 1
JULCVHLOALKRBP-UHFFFAOYSA-N n-(2-bromo-4-methylphenyl)-2-[[4-(furan-2-ylmethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound BrC1=CC(C)=CC=C1NC(=O)CSC(N1CC=2OC=CC=2)=NN=C1C1=CC=NC=C1 JULCVHLOALKRBP-UHFFFAOYSA-N 0.000 claims 1
LQUDRBJASPFYLC-UHFFFAOYSA-N n-(2-bromo-4-methylphenyl)-2-[[5-(3,4-dimethoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C1=C(OC)C(OC)=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=C(C)C=C1Br LQUDRBJASPFYLC-UHFFFAOYSA-N 0.000 claims 1
GMJJBBCOODDOMB-UHFFFAOYSA-N n-(2-bromophenyl)-2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1Br GMJJBBCOODDOMB-UHFFFAOYSA-N 0.000 claims 1
CRPDNPGPWNZEPH-UHFFFAOYSA-N n-(2-bromophenyl)-2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C2CCCCC2)N(C)C=1SCC(=O)NC1=CC=CC=C1Br CRPDNPGPWNZEPH-UHFFFAOYSA-N 0.000 claims 1
YTHXXVJIUJEHRK-UHFFFAOYSA-N n-(2-chlorophenyl)-2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC=C1Cl YTHXXVJIUJEHRK-UHFFFAOYSA-N 0.000 claims 1
WXECIJNGIJIJPN-UHFFFAOYSA-N n-(2-chlorophenyl)-2-[[4-methyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CC1=CC=CC(C=2N(C(SCC(=O)NC=3C(=CC=CC=3)Cl)=NN=2)C)=C1 WXECIJNGIJIJPN-UHFFFAOYSA-N 0.000 claims 1
CHMRECGWXBZPII-UHFFFAOYSA-N n-(2-chlorophenyl)-2-[[5-(2-methoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=CC=C1Cl CHMRECGWXBZPII-UHFFFAOYSA-N 0.000 claims 1
ZZRAECUAWNOJJY-UHFFFAOYSA-N n-(2-cyanophenyl)-2-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide Chemical compound N1=C2N(CC)C3=CC=CC=C3C2=NN=C1SCC(=O)NC1=CC=CC=C1C#N ZZRAECUAWNOJJY-UHFFFAOYSA-N 0.000 claims 1
IVTRRMRNZMWARJ-UHFFFAOYSA-N n-(2-ethoxyethyl)-4-hydroxy-n-[(4-hydroxyphenyl)methyl]benzamide Chemical compound C=1C=C(O)C=CC=1C(=O)N(CCOCC)CC1=CC=C(O)C=C1 IVTRRMRNZMWARJ-UHFFFAOYSA-N 0.000 claims 1
XYALKAYLERMMCO-UHFFFAOYSA-N n-(2-methoxyethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)NCCOC)C2=C1 XYALKAYLERMMCO-UHFFFAOYSA-N 0.000 claims 1
WDWQJJNEHFIHOJ-UHFFFAOYSA-N n-(2-methoxyphenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C WDWQJJNEHFIHOJ-UHFFFAOYSA-N 0.000 claims 1
CNZFKMXIRVXMQL-UHFFFAOYSA-N n-(2-methoxyphenyl)-2-[[4-methyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC(C)=C1 CNZFKMXIRVXMQL-UHFFFAOYSA-N 0.000 claims 1
HMZMSGWBOREIDD-UHFFFAOYSA-N n-(2-methoxyphenyl)-2-[[5-(2-methoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1OC HMZMSGWBOREIDD-UHFFFAOYSA-N 0.000 claims 1
ALEBBVNYTHDZDP-UHFFFAOYSA-N n-(2-methyl-4-nitrophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CC1=CC([N+]([O-])=O)=CC=C1NC(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 ALEBBVNYTHDZDP-UHFFFAOYSA-N 0.000 claims 1
QEYGWGBJCBXJBX-UHFFFAOYSA-N n-(2-methyl-5-nitrophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CC1=CC=C([N+]([O-])=O)C=C1NC(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 QEYGWGBJCBXJBX-UHFFFAOYSA-N 0.000 claims 1
XJLUUVMDZAFFCS-UHFFFAOYSA-N n-(2-nitrophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-3-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound [O-][N+](=O)C1=CC=CC=C1NC(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 XJLUUVMDZAFFCS-UHFFFAOYSA-N 0.000 claims 1
HMUADTMYQBFVGC-UHFFFAOYSA-N n-(2h-tetrazol-5-ylmethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC=1N=NNN=1 HMUADTMYQBFVGC-UHFFFAOYSA-N 0.000 claims 1
KHDSXVBJYDGQAL-UHFFFAOYSA-N n-(3-chloro-2-methylphenyl)-2-[[4-(furan-2-ylmethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC(=O)NC1=CC=CC(Cl)=C1C KHDSXVBJYDGQAL-UHFFFAOYSA-N 0.000 claims 1
PHIREEBXEVROBM-UHFFFAOYSA-N n-(3-chloro-2-methylphenyl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=CC(Cl)=C1C PHIREEBXEVROBM-UHFFFAOYSA-N 0.000 claims 1
OCRXKGNNHSRIBG-UHFFFAOYSA-N n-(3-chloro-2-methylphenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=CC(Cl)=C1C OCRXKGNNHSRIBG-UHFFFAOYSA-N 0.000 claims 1
PXEPHSRPBDSLMZ-UHFFFAOYSA-N n-(3-chloro-4-methylphenyl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=C(C)C(Cl)=C1 PXEPHSRPBDSLMZ-UHFFFAOYSA-N 0.000 claims 1
SORRCFVXHLUUQO-UHFFFAOYSA-N n-(3-chlorophenyl)-2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C=2C=CC=CC=2)N(CC)C=1SCC(=O)NC1=CC=CC(Cl)=C1 SORRCFVXHLUUQO-UHFFFAOYSA-N 0.000 claims 1
DPHUWIVGQOBOAU-UHFFFAOYSA-N n-(3-chlorophenyl)-2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=CC(Cl)=C1 DPHUWIVGQOBOAU-UHFFFAOYSA-N 0.000 claims 1
SATVWVSLXVHJLQ-UHFFFAOYSA-N n-(3-chlorophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-3-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound ClC1=CC=CC(NC(=O)CSC=2N(C(C=3C=NC=CC=3)=NN=2)CCC=2C=CC=CC=2)=C1 SATVWVSLXVHJLQ-UHFFFAOYSA-N 0.000 claims 1
RQLWAEFOAJVNGC-UHFFFAOYSA-N n-(3-chlorophenyl)-2-[[4-(furan-2-ylmethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC(=O)NC1=CC=CC(Cl)=C1 RQLWAEFOAJVNGC-UHFFFAOYSA-N 0.000 claims 1
PECWRZGEIHIIFN-UHFFFAOYSA-N n-(3-chlorophenyl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=CC(Cl)=C1 PECWRZGEIHIIFN-UHFFFAOYSA-N 0.000 claims 1
CKBXVNDBOLTQKK-UHFFFAOYSA-N n-(3-chlorophenyl)-2-[[5-methyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C=1C=CC=CC=1CCN1C(C)=NN=C1SCC(=O)NC1=CC=CC(Cl)=C1 CKBXVNDBOLTQKK-UHFFFAOYSA-N 0.000 claims 1
XXMHHNDEQCVSFJ-UHFFFAOYSA-N n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound CCN1C(SCC(=O)NC2=C(C=3CCCCC=3S2)C#N)=NN=C1C1=CC=CC=C1 XXMHHNDEQCVSFJ-UHFFFAOYSA-N 0.000 claims 1
XPJLFXGMNKRYBV-UHFFFAOYSA-N n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound CN1C(SCC(=O)NC2=C(C=3CCCCC=3S2)C#N)=NN=C1C1CCCCC1 XPJLFXGMNKRYBV-UHFFFAOYSA-N 0.000 claims 1
QDSFVYPBWBVQKY-UHFFFAOYSA-N n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[[4-(furan-2-ylmethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound S1C=2CCCCC=2C(C#N)=C1NC(=O)CSC(N1CC=2OC=CC=2)=NN=C1C1=CC=NC=C1 QDSFVYPBWBVQKY-UHFFFAOYSA-N 0.000 claims 1
FZLFKEFJWFIKNC-UHFFFAOYSA-N n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CCN1C(SCC(=O)NC2=C(C=3CCCCC=3S2)C#N)=NN=C1C1=CC=CC=C1OC FZLFKEFJWFIKNC-UHFFFAOYSA-N 0.000 claims 1
HTHKTJIANWVHFF-UHFFFAOYSA-N n-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[[5-(2-methoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=C(C#N)C(CCCC2)=C2S1 HTHKTJIANWVHFF-UHFFFAOYSA-N 0.000 claims 1
LAMZCIPJVZGTTN-UHFFFAOYSA-N n-(3-hydroxy-1-adamantyl)-1-methylindole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NC1(C2)CC(O)(C3)CC2CC3C1 LAMZCIPJVZGTTN-UHFFFAOYSA-N 0.000 claims 1
RUAIWPYLUWJCAM-UHFFFAOYSA-N n-(3-hydroxy-1-adamantyl)-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound S1C(C)=NC(C)=C1C(=O)NC1(C2)CC(O)(C3)CC2CC3C1 RUAIWPYLUWJCAM-UHFFFAOYSA-N 0.000 claims 1
PAZNKYMKSRAMHZ-UHFFFAOYSA-N n-(3-nitrophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-3-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound [O-][N+](=O)C1=CC=CC(NC(=O)CSC=2N(C(C=3C=NC=CC=3)=NN=2)CCC=2C=CC=CC=2)=C1 PAZNKYMKSRAMHZ-UHFFFAOYSA-N 0.000 claims 1
PZXTZHMGBQTRIJ-UHFFFAOYSA-N n-(3-nitrophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound [O-][N+](=O)C1=CC=CC(NC(=O)CSC=2N(C(C=3C=CN=CC=3)=NN=2)CCC=2C=CC=CC=2)=C1 PZXTZHMGBQTRIJ-UHFFFAOYSA-N 0.000 claims 1
LYNOIZAAFPMWQT-UHFFFAOYSA-N n-(4-acetylphenyl)-2-[(4-benzyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound C1=CC(C(=O)C)=CC=C1NC(=O)CSC(N1CC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 LYNOIZAAFPMWQT-UHFFFAOYSA-N 0.000 claims 1
DCYRIDDVROEAFQ-UHFFFAOYSA-N n-(4-acetylphenyl)-2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(=CC=2)C(C)=O)N(CC)C=1CC1=CC=CC=C1 DCYRIDDVROEAFQ-UHFFFAOYSA-N 0.000 claims 1
VSSIQNUQUMVFGU-UHFFFAOYSA-N n-(4-acetylphenyl)-2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=C(C(C)=O)C=C1 VSSIQNUQUMVFGU-UHFFFAOYSA-N 0.000 claims 1
HKKCWUXFWKMTON-UHFFFAOYSA-N n-(4-acetylphenyl)-2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound C1=CC(C(=O)C)=CC=C1NC(=O)CSC(N1C)=NN=C1C1CCCCC1 HKKCWUXFWKMTON-UHFFFAOYSA-N 0.000 claims 1
BDGPKIHJGCXARV-UHFFFAOYSA-N n-(4-acetylphenyl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=C(C(C)=O)C=C1 BDGPKIHJGCXARV-UHFFFAOYSA-N 0.000 claims 1
OSQJVDBWQTYHMW-UHFFFAOYSA-N n-(4-acetylphenyl)-2-[[4-ethyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C=C(C)C=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(C(C)=O)C=C1 OSQJVDBWQTYHMW-UHFFFAOYSA-N 0.000 claims 1
PXCUXXQQXFOWJK-UHFFFAOYSA-N n-(4-bromophenyl)-2-[(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C2CCCCC2)N(CC)C=1SCC(=O)NC1=CC=C(Br)C=C1 PXCUXXQQXFOWJK-UHFFFAOYSA-N 0.000 claims 1
MEPTZZXYZUSXJQ-UHFFFAOYSA-N n-(4-bromophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C1=CC(Br)=CC=C1NC(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 MEPTZZXYZUSXJQ-UHFFFAOYSA-N 0.000 claims 1
XCPOOVVFDXQBBU-UHFFFAOYSA-N n-(4-bromophenyl)-2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(Br)=CC=2)N(CC)C=1CNC1=CC=C(F)C=C1 XCPOOVVFDXQBBU-UHFFFAOYSA-N 0.000 claims 1
ZZAORWKXJHJAPB-UHFFFAOYSA-N n-(4-bromophenyl)-2-[[5-(2-bromophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)Br)N(CC)C=1SCC(=O)NC1=CC=C(Br)C=C1 ZZAORWKXJHJAPB-UHFFFAOYSA-N 0.000 claims 1
HZFLRKOGPXAOAM-UHFFFAOYSA-N n-(4-chloro-3-nitrophenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=C(Cl)C([N+]([O-])=O)=C1 HZFLRKOGPXAOAM-UHFFFAOYSA-N 0.000 claims 1
VMXWMXDCWYRQKH-UHFFFAOYSA-N n-(4-chloro-3-nitrophenyl)-2-[[5-(4-chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(Cl)C([N+]([O-])=O)=C1 VMXWMXDCWYRQKH-UHFFFAOYSA-N 0.000 claims 1
HIZNSNLNSQUJCR-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound N=1N=C(C2CCCCC2)N(C)C=1SCC(=O)NC1=CC=C(Cl)C=C1 HIZNSNLNSQUJCR-UHFFFAOYSA-N 0.000 claims 1
CQMRXNULWZNTSJ-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 CQMRXNULWZNTSJ-UHFFFAOYSA-N 0.000 claims 1
KBVPNDGMVIVBMJ-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[4-(furan-2-ylmethyl)-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1C(N1CC=2OC=CC=2)=NN=C1SCC(=O)NC1=CC=C(Cl)C=C1 KBVPNDGMVIVBMJ-UHFFFAOYSA-N 0.000 claims 1
JTFYOTIJUOSHHF-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[4-ethyl-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C(=CC=CC=2)OC)N(CC)C=1SCC(=O)NC1=CC=C(Cl)C=C1 JTFYOTIJUOSHHF-UHFFFAOYSA-N 0.000 claims 1
GKZIXEPSOLBANQ-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[4-ethyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(C=2C=C(C)C=CC=2)N(CC)C=1SCC(=O)NC1=CC=C(Cl)C=C1 GKZIXEPSOLBANQ-UHFFFAOYSA-N 0.000 claims 1
CNWFTMQJSZUWMR-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(Cl)=CC=2)N(CC)C=1CNC1=CC=C(F)C=C1 CNWFTMQJSZUWMR-UHFFFAOYSA-N 0.000 claims 1
XFOZBELQKKGBIE-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=C(Cl)C=C1 XFOZBELQKKGBIE-UHFFFAOYSA-N 0.000 claims 1
IRBCFSKQKDNGNZ-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[4-methyl-5-(thiophen-3-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound N=1N=C(SCC(=O)NC=2C=CC(Cl)=CC=2)N(C)C=1CC=1C=CSC=1 IRBCFSKQKDNGNZ-UHFFFAOYSA-N 0.000 claims 1
WCOODDVFMLCDJL-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[5-methyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C=1C=CC=CC=1CCN1C(C)=NN=C1SCC(=O)NC1=CC=C(Cl)C=C1 WCOODDVFMLCDJL-UHFFFAOYSA-N 0.000 claims 1
OROXEFABSSXTTR-UHFFFAOYSA-N n-(4-ethoxyphenyl)-2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound C1=CC(OCC)=CC=C1NC(=O)CSC(N1CC)=NN=C1C1=CC=CC=C1 OROXEFABSSXTTR-UHFFFAOYSA-N 0.000 claims 1
KBWVLZPAEJCZTE-UHFFFAOYSA-N n-(4-ethoxyphenyl)-2-[[4-ethyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C1=CC(OCC)=CC=C1NC(=O)CSC(N1CC)=NN=C1C1=CC=CC(C)=C1 KBWVLZPAEJCZTE-UHFFFAOYSA-N 0.000 claims 1
DFPZIJGUASCDIN-UHFFFAOYSA-N n-(4-ethoxyphenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C1=CC(OCC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C DFPZIJGUASCDIN-UHFFFAOYSA-N 0.000 claims 1
YKECOWKKDWZLET-UHFFFAOYSA-N n-(4-ethylphenyl)-2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide Chemical compound C1=CC(CC)=CC=C1NC(=O)CSC(N1CC)=NN=C1C1=CC=CC=C1 YKECOWKKDWZLET-UHFFFAOYSA-N 0.000 claims 1
WKFJHVXKDNLNMD-UHFFFAOYSA-N n-(4-fluorophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C1=CC(F)=CC=C1NC(=O)CSC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=NC=C1 WKFJHVXKDNLNMD-UHFFFAOYSA-N 0.000 claims 1
IUGBDURTRTVELS-UHFFFAOYSA-N n-(4-iodo-2-methylphenyl)-2-[[5-(2-methoxyphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=CC=CC=C1C(N1C)=NN=C1SCC(=O)NC1=CC=C(I)C=C1C IUGBDURTRTVELS-UHFFFAOYSA-N 0.000 claims 1
QMCUEPKMXSQOAE-UHFFFAOYSA-N n-(4-methoxyphenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound C1=CC(OC)=CC=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C QMCUEPKMXSQOAE-UHFFFAOYSA-N 0.000 claims 1
IDLUDDWWXQUMRG-UHFFFAOYSA-N n-(4-methyl-3-nitrophenyl)-2-[[4-methyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound COC1=C(OC)C(OC)=CC(C=2N(C(SCC(=O)NC=3C=C(C(C)=CC=3)[N+]([O-])=O)=NN=2)C)=C1 IDLUDDWWXQUMRG-UHFFFAOYSA-N 0.000 claims 1
XUAGYIYYHZBRTG-UHFFFAOYSA-N n-(4-nitrophenyl)-2-[[4-(2-phenylethyl)-5-pyridin-3-yl-1,2,4-triazol-3-yl]sulfanyl]propanamide Chemical compound C=1C=C([N+]([O-])=O)C=CC=1NC(=O)C(C)SC(N1CCC=2C=CC=CC=2)=NN=C1C1=CC=CN=C1 XUAGYIYYHZBRTG-UHFFFAOYSA-N 0.000 claims 1
VBBLFLXIEQHQRF-UHFFFAOYSA-N n-(5-chloro-2-methylphenyl)-2-[[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound CC1=CC=C(Cl)C=C1NC(=O)CSC(N1C)=NN=C1C1=CC=CC=C1C VBBLFLXIEQHQRF-UHFFFAOYSA-N 0.000 claims 1
OXOLHNKQFBLVMD-UHFFFAOYSA-N n-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[[5-methyl-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide Chemical compound S1C(CC)=NN=C1NC(=O)CSC1=NN=C(C)N1CCC1=CC=CC=C1 OXOLHNKQFBLVMD-UHFFFAOYSA-N 0.000 claims 1
DSLCCYVKHAKUCM-UHFFFAOYSA-N n-(6-hydroxyhexyl)-n-[(4-hydroxyphenyl)methyl]-4-propylbenzamide Chemical compound C1=CC(CCC)=CC=C1C(=O)N(CCCCCCO)CC1=CC=C(O)C=C1 DSLCCYVKHAKUCM-UHFFFAOYSA-N 0.000 claims 1
IVJKQKQWJVEAPX-UHFFFAOYSA-N n-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-1h-indole-6-carboxamide Chemical compound C1=C2C=CNC2=CC(C(=O)NC2CC3CCC(C2)N3C)=C1 IVJKQKQWJVEAPX-UHFFFAOYSA-N 0.000 claims 1
YKTQGTHNZBBNQQ-UHFFFAOYSA-N n-(azepan-1-yl)-1-methylindole-3-carboxamide Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)NN1CCCCCC1 YKTQGTHNZBBNQQ-UHFFFAOYSA-N 0.000 claims 1
ZTOMRIQLVTWRLT-UHFFFAOYSA-N n-(cyanomethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1=C2NC=C(C(=O)NCC#N)C2=CC(C(=O)N2C3CC(CC(C)(C)C3)(C2)C)=C1 ZTOMRIQLVTWRLT-UHFFFAOYSA-N 0.000 claims 1
HFPHUGPYWNUHRW-UHFFFAOYSA-N n-(furan-2-ylmethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC1=CC=CO1 HFPHUGPYWNUHRW-UHFFFAOYSA-N 0.000 claims 1
RNBFYMRWWRWKHZ-UHFFFAOYSA-N n-(oxolan-2-ylmethyl)-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC1CCCO1 RNBFYMRWWRWKHZ-UHFFFAOYSA-N 0.000 claims 1
JJRQDQPXYISFOI-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-n-(3-methylbutyl)-4-propylbenzamide Chemical compound C1=CC(CCC)=CC=C1C(=O)N(CCC(C)C)CC1=CC=CC=C1O JJRQDQPXYISFOI-UHFFFAOYSA-N 0.000 claims 1
TWJPLAKRSAQWDW-UHFFFAOYSA-N n-[(2-hydroxyphenyl)methyl]-n-(3-methylbutyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCC(C)C)CC1=CC=CC=C1O TWJPLAKRSAQWDW-UHFFFAOYSA-N 0.000 claims 1
QEXGSNIMFAVYDW-UHFFFAOYSA-N n-[(2-methoxyphenyl)methyl]-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine Chemical compound COC1=CC=CC=C1CNC1=NN2C(C=3C=CC=CC=3)=NN=C2C=C1 QEXGSNIMFAVYDW-UHFFFAOYSA-N 0.000 claims 1
RRTTTYAOACTRLH-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-(3-propan-2-yloxypropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCCOC(C)C)CC1=CC=CC(O)=C1 RRTTTYAOACTRLH-UHFFFAOYSA-N 0.000 claims 1
ZEYNZPOUBJJRNL-UHFFFAOYSA-N n-[(3-hydroxyphenyl)methyl]-n-(4-methylpentyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCCC(C)C)CC1=CC=CC(O)=C1 ZEYNZPOUBJJRNL-UHFFFAOYSA-N 0.000 claims 1
CPFNJNJDMSVPFK-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(2-methylpropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CC(C)C)CC1=CC=C(O)C=C1 CPFNJNJDMSVPFK-UHFFFAOYSA-N 0.000 claims 1
VQFVBRBHOPGVJQ-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(3-methylbutyl)-4-propylbenzamide Chemical compound C1=CC(CCC)=CC=C1C(=O)N(CCC(C)C)CC1=CC=C(O)C=C1 VQFVBRBHOPGVJQ-UHFFFAOYSA-N 0.000 claims 1
ASANEODLTKPBTJ-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(3-methylbutyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCC(C)C)CC1=CC=C(O)C=C1 ASANEODLTKPBTJ-UHFFFAOYSA-N 0.000 claims 1
ACTJJEUWBVIISW-UHFFFAOYSA-N n-[(4-hydroxyphenyl)methyl]-n-(3-propan-2-yloxypropyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)N(CCCOC(C)C)CC1=CC=C(O)C=C1 ACTJJEUWBVIISW-UHFFFAOYSA-N 0.000 claims 1
OYTJXXFVCAJCET-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1=CC(OC)=CC=C1CNC(=O)C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 OYTJXXFVCAJCET-UHFFFAOYSA-N 0.000 claims 1
HSNPWNNEBQGHIO-UHFFFAOYSA-N n-[(5-benzylsulfanyl-4-ethyl-1,2,4-triazol-3-yl)methyl]-3-(trifluoromethyl)aniline Chemical compound N=1N=C(SCC=2C=CC=CC=2)N(CC)C=1CNC1=CC=CC(C(F)(F)F)=C1 HSNPWNNEBQGHIO-UHFFFAOYSA-N 0.000 claims 1
HXHMFOCQKVNKSX-UHFFFAOYSA-N n-[(5-benzylsulfanyl-4-ethyl-1,2,4-triazol-3-yl)methyl]-4-chloroaniline Chemical compound N=1N=C(SCC=2C=CC=CC=2)N(CC)C=1CNC1=CC=C(Cl)C=C1 HXHMFOCQKVNKSX-UHFFFAOYSA-N 0.000 claims 1
MWCLCCDPVFUOHF-UHFFFAOYSA-N n-[(5-benzylsulfanyl-4-ethyl-1,2,4-triazol-3-yl)methyl]-4-fluoroaniline Chemical compound N=1N=C(SCC=2C=CC=CC=2)N(CC)C=1CNC1=CC=C(F)C=C1 MWCLCCDPVFUOHF-UHFFFAOYSA-N 0.000 claims 1
URGWKIHKPADQEK-UHFFFAOYSA-N n-[(5-hydroxy-1,3,3-trimethylcyclohexyl)methyl]-1h-indole-5-carboxamide Chemical compound C1C(C)(C)CC(O)CC1(C)CNC(=O)C1=CC=C(NC=C2)C2=C1 URGWKIHKPADQEK-UHFFFAOYSA-N 0.000 claims 1
MFPYDQQQKDTNIL-UHFFFAOYSA-N n-[1-[5-[(4-tert-butylphenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]ethyl]-4-chlorobenzenesulfonamide Chemical compound N=1N=C(C(C)NS(=O)(=O)C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(C(C)(C)C)C=C1 MFPYDQQQKDTNIL-UHFFFAOYSA-N 0.000 claims 1
MFIKROXOKVHJEV-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-n-methyl-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CC=C2NC=C(C(=O)N(C)CCN(C)C)C2=C1 MFIKROXOKVHJEV-UHFFFAOYSA-N 0.000 claims 1
JOCWJCGOLBOXPJ-UHFFFAOYSA-N n-[3-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indol-7-yl]acetamide Chemical compound C1C(CC(C)(C)C2)(C)CC2N1C(=O)C1=CNC2=C1C=CC=C2NC(=O)C JOCWJCGOLBOXPJ-UHFFFAOYSA-N 0.000 claims 1
YOYOWAJKBHTARZ-UHFFFAOYSA-N n-[3-(4-methylpiperazin-1-yl)propyl]-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1CN(C)CCN1CCCNC(=O)C1=CNC2=CC=C(C(=O)N3C4CC(CC(C)(C)C4)(C)C3)C=C12 YOYOWAJKBHTARZ-UHFFFAOYSA-N 0.000 claims 1
JCZHIUIBWFMQAP-UHFFFAOYSA-N n-[4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C(=O)N1C(CC(C)(C)C2)CC2(C)C1 JCZHIUIBWFMQAP-UHFFFAOYSA-N 0.000 claims 1
AAYDTRXEZOFOGV-UHFFFAOYSA-N n-[4-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)phenyl]thiophene-2-sulfonamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C1)=CC=C1NS(=O)(=O)C1=CC=CS1 AAYDTRXEZOFOGV-UHFFFAOYSA-N 0.000 claims 1
HUTRBWHPRNSUPR-UHFFFAOYSA-N n-[4-[(4-ethyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2C=NC=CC=2)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 HUTRBWHPRNSUPR-UHFFFAOYSA-N 0.000 claims 1
VBJYGQCRTQZHKS-UHFFFAOYSA-N n-[4-[5-[(2-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]phenyl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)NC1=CC=C(C=2N(C(SCC=3C(=CC=CC=3)Cl)=NN=2)C)C=C1 VBJYGQCRTQZHKS-UHFFFAOYSA-N 0.000 claims 1
DYOAMVROJXEOQS-UHFFFAOYSA-N n-[4-[[4-ethyl-5-(1h-indol-3-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound CCN1C(CC=2C3=CC=CC=C3NC=2)=NN=C1SCC1=CC=C(NC(C)=O)C=C1 DYOAMVROJXEOQS-UHFFFAOYSA-N 0.000 claims 1
AXVKLGAEWBEFDB-UHFFFAOYSA-N n-[4-[[4-ethyl-5-(2-methylsulfanylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2C(=NC=CC=2)SC)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 AXVKLGAEWBEFDB-UHFFFAOYSA-N 0.000 claims 1
UPSKOXRXTUPEGP-UHFFFAOYSA-N n-[4-[[4-ethyl-5-(3-hydroxypropyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound CCN1C(CCCO)=NN=C1SCC1=CC=C(NC(C)=O)C=C1 UPSKOXRXTUPEGP-UHFFFAOYSA-N 0.000 claims 1
MKIPALOJKHNPBZ-UHFFFAOYSA-N n-[4-[[4-ethyl-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2C=CC(OC)=CC=2)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 MKIPALOJKHNPBZ-UHFFFAOYSA-N 0.000 claims 1
TXSPMALGFZQOHA-UHFFFAOYSA-N n-[4-[[4-ethyl-5-(5-methylthiophen-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2SC(C)=CC=2)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 TXSPMALGFZQOHA-UHFFFAOYSA-N 0.000 claims 1
IUXSXJFKIRAFRC-UHFFFAOYSA-N n-[4-[[4-ethyl-5-[1-phenyl-5-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C2=C(N(N=C2)C=2C=CC=CC=2)C(F)(F)F)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 IUXSXJFKIRAFRC-UHFFFAOYSA-N 0.000 claims 1
SOJQRABDNRLSEX-UHFFFAOYSA-N n-[4-[[5-(1,3-benzodioxol-5-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2C=C3OCOC3=CC=2)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 SOJQRABDNRLSEX-UHFFFAOYSA-N 0.000 claims 1
QTFZZTQNLNYSEX-UHFFFAOYSA-N n-[4-[[5-(1-benzothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2SC3=CC=CC=C3C=2)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 QTFZZTQNLNYSEX-UHFFFAOYSA-N 0.000 claims 1
GBNZHSRQJXVCGI-UHFFFAOYSA-N n-[4-[[5-(4-chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2C=CC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 GBNZHSRQJXVCGI-UHFFFAOYSA-N 0.000 claims 1
SYWCOHKGECVQPI-UHFFFAOYSA-N n-[4-[[5-(5-chlorothiophen-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2SC(Cl)=CC=2)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 SYWCOHKGECVQPI-UHFFFAOYSA-N 0.000 claims 1
JFLDRUSVKJSDFM-UHFFFAOYSA-N n-[4-[[5-[4-(2,5-dimethylpyrrol-1-yl)phenyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]acetamide Chemical compound N=1N=C(C=2C=CC(=CC=2)N2C(=CC=C2C)C)N(CC)C=1SCC1=CC=C(NC(C)=O)C=C1 JFLDRUSVKJSDFM-UHFFFAOYSA-N 0.000 claims 1
JTAJDRPNOSMJDJ-UHFFFAOYSA-N n-[[2-[(4-fluorophenyl)methylamino]-1,3-thiazol-4-yl]methyl]-n-(2-phenylethyl)butanamide Chemical compound C=1SC(NCC=2C=CC(F)=CC=2)=NC=1CN(C(=O)CCC)CCC1=CC=CC=C1 JTAJDRPNOSMJDJ-UHFFFAOYSA-N 0.000 claims 1
WPDJDHRXHNJFKD-UHFFFAOYSA-N n-[[4-(trifluoromethyl)phenyl]methyl]-5-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)-1h-indole-3-carboxamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=C12)=CC=C1NC=C2C(=O)NCC1=CC=C(C(F)(F)F)C=C1 WPDJDHRXHNJFKD-UHFFFAOYSA-N 0.000 claims 1
FJFBXOVZXGTEIY-UHFFFAOYSA-N n-[[4-ethyl-5-[(4-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-4-fluoroaniline Chemical compound N=1N=C(SCC=2C=CC(C)=CC=2)N(CC)C=1CNC1=CC=C(F)C=C1 FJFBXOVZXGTEIY-UHFFFAOYSA-N 0.000 claims 1
LWYNCCMTLFTBKO-UHFFFAOYSA-N n-[[4-ethyl-5-[(4-nitrophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]methyl]-2,4-dimethylaniline Chemical compound N=1N=C(SCC=2C=CC(=CC=2)[N+]([O-])=O)N(CC)C=1CNC1=CC=C(C)C=C1C LWYNCCMTLFTBKO-UHFFFAOYSA-N 0.000 claims 1
JXGCCLJJGJZRFO-UHFFFAOYSA-N n-[[5-[(4-chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]methyl]-4-fluoroaniline Chemical compound N=1N=C(SCC=2C=CC(Cl)=CC=2)N(CC)C=1CNC1=CC=C(F)C=C1 JXGCCLJJGJZRFO-UHFFFAOYSA-N 0.000 claims 1
IHRIRTAQBFITOO-UHFFFAOYSA-N n-[[5-[2-[3,5-bis(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]-3-methoxybenzamide Chemical compound C1=CC(OC)=CC=C1C1N(C(=O)CSC=2N(C(CNC(=O)C=3C=C(OC)C=CC=3)=NN=2)C)N=C(C=2C=CC(OC)=CC=2)C1 IHRIRTAQBFITOO-UHFFFAOYSA-N 0.000 claims 1
GBXRIONXERFQKT-UHFFFAOYSA-N n-[[5-[2-[3-(4-methoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]-4-morpholin-4-ylsulfonylbenzamide Chemical compound C1=CC(OC)=CC=C1C1N(C(=O)CSC=2N(C(CNC(=O)C=3C=CC(=CC=3)S(=O)(=O)N3CCOCC3)=NN=2)C)N=C(C=2SC=CC=2)C1 GBXRIONXERFQKT-UHFFFAOYSA-N 0.000 claims 1
VPACQFVUNBXRSY-UHFFFAOYSA-N n-[[5-[2-[3-(4-methoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]-4-piperidin-1-ylsulfonylbenzamide Chemical compound C1=CC(OC)=CC=C1C1N(C(=O)CSC=2N(C(CNC(=O)C=3C=CC(=CC=3)S(=O)(=O)N3CCCCC3)=NN=2)C)N=C(C=2SC=CC=2)C1 VPACQFVUNBXRSY-UHFFFAOYSA-N 0.000 claims 1
ZVPVUBGUTYYBPG-UHFFFAOYSA-N n-[[5-[2-[3-(4-methoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]-4-pyrrolidin-1-ylsulfonylbenzamide Chemical compound C1=CC(OC)=CC=C1C1N(C(=O)CSC=2N(C(CNC(=O)C=3C=CC(=CC=3)S(=O)(=O)N3CCCC3)=NN=2)C)N=C(C=2SC=CC=2)C1 ZVPVUBGUTYYBPG-UHFFFAOYSA-N 0.000 claims 1
UWLUGCSIAPHEKH-UHFFFAOYSA-N n-[[5-[2-[3-(4-methoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]benzamide Chemical compound C1=CC(OC)=CC=C1C1N(C(=O)CSC=2N(C(CNC(=O)C=3C=CC=CC=3)=NN=2)C)N=C(C=2SC=CC=2)C1 UWLUGCSIAPHEKH-UHFFFAOYSA-N 0.000 claims 1
INYHTXZCWGKMOL-UHFFFAOYSA-N n-benzyl-3-(3,3,5-trimethyl-7-azabicyclo[3.2.1]octane-7-carbonyl)benzenesulfonamide Chemical compound C1C(C)(C)CC(C)(C2)CC1N2C(=O)C(C=1)=CC=CC=1S(=O)(=O)NCC1=CC=CC=C1 INYHTXZCWGKMOL-UHFFFAOYSA-N 0.000 claims 1
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