EA200801243A1 - Фармацевтическое применение замещенных амидов - Google Patents

Фармацевтическое применение замещенных амидов

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Publication number
EA200801243A1
EA200801243A1 EA200801243A EA200801243A EA200801243A1 EA 200801243 A1 EA200801243 A1 EA 200801243A1 EA 200801243 A EA200801243 A EA 200801243A EA 200801243 A EA200801243 A EA 200801243A EA 200801243 A1 EA200801243 A1 EA 200801243A1
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EA
Eurasian Patent Office
Prior art keywords
substituted amides
compounds
pharmaceutical application
disclosed
pharmaceutical compositions
Prior art date
Application number
EA200801243A
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English (en)
Inventor
Хенрик Суне Андерсен
Анкер Стеен Йергенсен
Джон Пол Килберн
Гита Камилла Тейлгор Кампен
Серен Эбдруп
Original Assignee
Транстек Фарма
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Транстек Фарма filed Critical Транстек Фарма
Publication of EA200801243A1 publication Critical patent/EA200801243A1/ru

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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Раскрыто применение замещенных амидов для модулирования активности 11β-гидроксистероид дегидрогеназы типа 1 (11βHSD1) и применение этих соединений в качестве фармацевтических композиций. Кроме того, раскрыт новый класс замещенных амидов, их применение в терапии, фармацевтические композиции, включающие эти соединения, а также их использование при производстве лекарственных препаратов. Настоящие соединения являются модуляторами и более специфичными ингибиторами активности 11βHSD1 и могут быть полезными при лечении ряда медицинских расстройств, при которых желательна пониженная внутриклеточная концентрация активного глюкокортикоида.
EA200801243A 2005-11-01 2006-11-01 Фармацевтическое применение замещенных амидов EA200801243A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05110228 2005-11-01
EP06116808 2006-07-07
PCT/EP2006/068015 WO2007051810A2 (en) 2005-11-01 2006-11-01 Pharmaceutical use of substituted amides

Publications (1)

Publication Number Publication Date
EA200801243A1 true EA200801243A1 (ru) 2008-10-30

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EA200801243A EA200801243A1 (ru) 2005-11-01 2006-11-01 Фармацевтическое применение замещенных амидов

Country Status (9)

Country Link
US (1) US20090124598A1 (ru)
EP (1) EP1948190A2 (ru)
JP (1) JP2009514818A (ru)
KR (1) KR20080076916A (ru)
AU (1) AU2006310518A1 (ru)
CA (1) CA2627306A1 (ru)
EA (1) EA200801243A1 (ru)
IL (1) IL191035A0 (ru)
WO (1) WO2007051810A2 (ru)

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AU2007236049A1 (en) 2006-04-07 2007-10-18 High Point Pharmaceuticals, Llc 11beta-hydroxysteroid dehydrogenase type 1 active compounds
CA2649677A1 (en) * 2006-05-01 2007-11-15 Incyte Corporation Tetrasubstituted ureas as modulators of 11-.beta. hydroxyl steroid dehydrogenase type 1
EP2038255A2 (en) * 2006-06-16 2009-03-25 High Point Pharmaceuticals, LLC Pharmaceutical use of substituted piperidine carboxamides
EP1878721A1 (en) * 2006-07-13 2008-01-16 Novo Nordisk A/S 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
US8048908B2 (en) * 2006-07-13 2011-11-01 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
RU2009108280A (ru) 2006-08-08 2010-09-20 Санофи-Авентис (Fr) Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение
US20110003852A1 (en) * 2007-02-23 2011-01-06 Soren Ebdrup N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
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