JP2008538749A5

JP2008538749A5 -

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Publication number: JP2008538749A5
Authority: JP; Japan
Prior art keywords: ethyl; propyl; phenoxy; ureido; phenyl
Prior art date: 2006-04-14
Legal status : Pending

Application number

JP2008505929A

Other languages

English (en)

Japanese (ja)

Other versions

JP2008538749A (ja

Filing date

2006-04-14

Publication date

2009-04-09

2005-04-15 Priority claimed from FR0503795A external-priority patent/FR2884516B1/fr

2006-04-14 Application filed filed Critical

2008-11-06 Publication of JP2008538749A publication Critical patent/JP2008538749A/ja

2009-04-09 Publication of JP2008538749A5 publication Critical patent/JP2008538749A5/ja

Status Pending legal-status Critical Current

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-1 trifluoromethoxy, aminocarbonyl Chemical group 0.000 claims 81
229910052757 nitrogen Inorganic materials 0.000 claims 29
150000001875 compounds Chemical class 0.000 claims 24
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 21
125000000623 heterocyclic group Chemical group 0.000 claims 17
125000003545 alkoxy group Chemical group 0.000 claims 16
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 15
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 14
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 13
125000004433 nitrogen atom Chemical group N* 0.000 claims 13
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 11
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 11
HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 claims 10
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 8
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 7
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 7
125000006528 (C2-C6) alkyl group Chemical group 0.000 claims 7
HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 7
125000000217 alkyl group Chemical group 0.000 claims 7
125000000753 cycloalkyl group Chemical group 0.000 claims 7
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims 6
125000002947 alkylene group Chemical group 0.000 claims 6
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 6
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 6
125000004430 oxygen atom Chemical group O* 0.000 claims 6
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 5
RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 5
125000001072 heteroaryl group Chemical group 0.000 claims 5
229910052760 oxygen Inorganic materials 0.000 claims 5
239000001301 oxygen Substances 0.000 claims 5
239000008194 pharmaceutical composition Substances 0.000 claims 5
208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical class C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
208000002551 irritable bowel syndrome Diseases 0.000 claims 4
229910052717 sulfur Inorganic materials 0.000 claims 4
125000004434 sulfur atom Chemical group 0.000 claims 4
IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 3
QMNUDYFKZYBWQX-UHFFFAOYSA-N 1H-quinazolin-4-one Chemical compound C1=CC=C2C(=O)N=CNC2=C1 QMNUDYFKZYBWQX-UHFFFAOYSA-N 0.000 claims 3
125000001118 alkylidene group Chemical group 0.000 claims 3
125000003118 aryl group Chemical group 0.000 claims 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
201000010099 disease Diseases 0.000 claims 3
239000003814 drug Substances 0.000 claims 3
125000001153 fluoro group Chemical group F* 0.000 claims 3
125000005843 halogen group Chemical group 0.000 claims 3
150000004677 hydrates Chemical class 0.000 claims 3
PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 claims 3
239000000203 mixture Substances 0.000 claims 3
230000003287 optical effect Effects 0.000 claims 3
150000003839 salts Chemical class 0.000 claims 3
239000012453 solvate Substances 0.000 claims 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
GLUABPSZMHYCNO-UHFFFAOYSA-N 1,2,3,3a,4,5,6,6a-octahydropyrrolo[3,2-b]pyrrole Chemical compound N1CCC2NCCC21 GLUABPSZMHYCNO-UHFFFAOYSA-N 0.000 claims 2
GJKVQTRICWNJOP-UHFFFAOYSA-N 1,2,3,5-tetrahydro-4,1-benzoxazepine Chemical compound N1CCOCC2=CC=CC=C21 GJKVQTRICWNJOP-UHFFFAOYSA-N 0.000 claims 2
FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 claims 2
HTSQWLLKIZBMEO-UHFFFAOYSA-N 1,5-diazocane Chemical compound C1CNCCCNC1 HTSQWLLKIZBMEO-UHFFFAOYSA-N 0.000 claims 2
HYLJXJSMGIOVIK-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1,5-benzoxazepine Chemical compound O1CCCNC2=CC=CC=C21 HYLJXJSMGIOVIK-UHFFFAOYSA-N 0.000 claims 2
DDVRNOMZDQTUNS-UHFFFAOYSA-N 2,7-diazaspiro[4.4]nonane Chemical compound C1NCCC11CNCC1 DDVRNOMZDQTUNS-UHFFFAOYSA-N 0.000 claims 2
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 2
YRLORWPBJZEGBX-UHFFFAOYSA-N 3,4-dihydro-2h-1,4-benzoxazine Chemical compound C1=CC=C2NCCOC2=C1 YRLORWPBJZEGBX-UHFFFAOYSA-N 0.000 claims 2
YWPMKTWUFVOFPL-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinolin-1-one Chemical compound C1=CC=C2C(=O)NCCC2=C1 YWPMKTWUFVOFPL-UHFFFAOYSA-N 0.000 claims 2
208000007848 Alcoholism Diseases 0.000 claims 2
206010002383 Angina Pectoris Diseases 0.000 claims 2
208000019901 Anxiety disease Diseases 0.000 claims 2
206010003225 Arteriospasm coronary Diseases 0.000 claims 2
201000001320 Atherosclerosis Diseases 0.000 claims 2
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
208000032841 Bulimia Diseases 0.000 claims 2
206010006550 Bulimia nervosa Diseases 0.000 claims 2
208000011231 Crohn disease Diseases 0.000 claims 2
206010012335 Dependence Diseases 0.000 claims 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
208000018522 Gastrointestinal disease Diseases 0.000 claims 2
206010019280 Heart failures Diseases 0.000 claims 2
206010020751 Hypersensitivity Diseases 0.000 claims 2
206010020772 Hypertension Diseases 0.000 claims 2
206010061218 Inflammation Diseases 0.000 claims 2
101710151321 Melanostatin Proteins 0.000 claims 2
208000001145 Metabolic Syndrome Diseases 0.000 claims 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
102400000064 Neuropeptide Y Human genes 0.000 claims 2
208000008589 Obesity Diseases 0.000 claims 2
208000002193 Pain Diseases 0.000 claims 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
208000003782 Raynaud disease Diseases 0.000 claims 2
208000012322 Raynaud phenomenon Diseases 0.000 claims 2
DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 2
201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
230000002159 abnormal effect Effects 0.000 claims 2
125000003282 alkyl amino group Chemical group 0.000 claims 2
230000007815 allergy Effects 0.000 claims 2
208000022531 anorexia Diseases 0.000 claims 2
230000036506 anxiety Effects 0.000 claims 2
210000003737 chromaffin cell Anatomy 0.000 claims 2
206010061428 decreased appetite Diseases 0.000 claims 2
229940079593 drug Drugs 0.000 claims 2
206010013663 drug dependence Diseases 0.000 claims 2
230000020595 eating behavior Effects 0.000 claims 2
230000037406 food intake Effects 0.000 claims 2
235000012631 food intake Nutrition 0.000 claims 2
230000004054 inflammatory process Effects 0.000 claims 2
208000001286 intracranial vasospasm Diseases 0.000 claims 2
208000028867 ischemia Diseases 0.000 claims 2
125000002950 monocyclic group Chemical group 0.000 claims 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 claims 2
235000020824 obesity Nutrition 0.000 claims 2
230000036407 pain Effects 0.000 claims 2
125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 claims 2
XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 claims 2
125000003367 polycyclic group Chemical group 0.000 claims 2
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 2
208000011117 substance-related disease Diseases 0.000 claims 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
125000006596 (C1-C3) alkylcarbonyloxy group Chemical group 0.000 claims 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
QFCMBRXRVQRSSF-UHFFFAOYSA-N 1,2,3,3a,4,5,6,6a-octahydropyrrolo[3,4-c]pyrrole Chemical compound C1NCC2CNCC21 QFCMBRXRVQRSSF-UHFFFAOYSA-N 0.000 claims 1
OGOWMVYFFWEWQT-UHFFFAOYSA-N 1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine Chemical compound O1C2=CC=CC=C2C2=C1CCNC2 OGOWMVYFFWEWQT-UHFFFAOYSA-N 0.000 claims 1
XNZPEHYZTCDIGW-UHFFFAOYSA-N 1,5-diazocan-2-one Chemical compound O=C1CCNCCCN1 XNZPEHYZTCDIGW-UHFFFAOYSA-N 0.000 claims 1
DOUXDVJGQDOJQO-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[2-fluoro-4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]indole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C(=CC(OC=4C=C(F)C(NC(=O)NC(CC)CC)=CC=4)=CC=3)F)C=C2C=C1 DOUXDVJGQDOJQO-UHFFFAOYSA-N 0.000 claims 1
ZNZQHUJVFBGGSS-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]indole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C=C(C)C(OC=4C=CC(NC(=O)NC(CC)CC)=CC=4)=CC=3)C=C2C=C1 ZNZQHUJVFBGGSS-UHFFFAOYSA-N 0.000 claims 1
IRVWBMPPWDTJQQ-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[4-[2,5-difluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]indole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C=CC(OC=4C(=CC(NC(=O)NC(CC)CC)=C(F)C=4)F)=CC=3)C=C2C=C1 IRVWBMPPWDTJQQ-UHFFFAOYSA-N 0.000 claims 1
RNZACGFFOMPGMO-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-2-fluorophenyl]indole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C(=CC(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OCC)=CC=3)F)C=C2C=C1 RNZACGFFOMPGMO-UHFFFAOYSA-N 0.000 claims 1
CYKXUGCWXCBBTL-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2,3-dihydroindole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C=CC(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OCC)=CC=3)C=C2CC1 CYKXUGCWXCBBTL-UHFFFAOYSA-N 0.000 claims 1
FZOJKYLOVHTPFT-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]indole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C=CC(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OCC)=CC=3)C=C2C=C1 FZOJKYLOVHTPFT-UHFFFAOYSA-N 0.000 claims 1
VLBAKMLLPHOSLB-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]indole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C=CC(OC=4C=CC(NC(=O)NC(CC)CC)=CC=4)=CC=3)C=C2C=C1 VLBAKMLLPHOSLB-UHFFFAOYSA-N 0.000 claims 1
KJHLAFQGWOZULA-UHFFFAOYSA-N 1-(1-butylpiperidin-4-yl)-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]indole-5-carboxamide Chemical compound C1CN(CCCC)CCC1N1C2=CC=C(C(=O)NC=3C=CC(OC=4C(=CC(NC(=O)NC(CC)CC)=C(F)C=4)OC)=CC=3)C=C2C=C1 KJHLAFQGWOZULA-UHFFFAOYSA-N 0.000 claims 1
XCXKHVZKTQBQHC-UHFFFAOYSA-N 1-[3-(4-hydroxypiperidin-1-yl)propyl]-n-[4-[2-(methylcarbamoyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]indole-5-carboxamide Chemical compound CNC(=O)C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(CCCN2CCC(O)CC2)C=C2)C2=C1 XCXKHVZKTQBQHC-UHFFFAOYSA-N 0.000 claims 1
XNZJFGSDOWXSPQ-UHFFFAOYSA-N 1-[3-(4-hydroxypiperidin-1-yl)propyl]-n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]indole-5-carboxamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=C(N(CCCN2CCC(O)CC2)C=C2)C2=C1 XNZJFGSDOWXSPQ-UHFFFAOYSA-N 0.000 claims 1
CGAZZAAGCUADIW-UHFFFAOYSA-N 1-[3-methoxy-4-[4-[5-(1-methylpiperidin-4-yl)oxy-1-benzofuran-2-yl]phenoxy]phenyl]-3-pentan-3-ylurea Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC1=CC=C(C=2OC3=CC=C(OC4CCN(C)CC4)C=C3C=2)C=C1 CGAZZAAGCUADIW-UHFFFAOYSA-N 0.000 claims 1
XYLYLOGJHZTKOJ-UHFFFAOYSA-N 1-[4-[2-[4-(1-butylpiperidin-4-yl)oxyphenyl]-1-ethylindol-5-yl]oxy-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C=2N(C3=CC=C(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OC)C=C3C=2)CC)C=C1 XYLYLOGJHZTKOJ-UHFFFAOYSA-N 0.000 claims 1
LXSJTVFHEQRNRV-UHFFFAOYSA-N 1-[4-[2-[4-(1-butylpiperidin-4-yl)oxyphenyl]-1-methylbenzimidazol-5-yl]oxy-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C=2N(C3=CC=C(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OC)C=C3N=2)C)C=C1 LXSJTVFHEQRNRV-UHFFFAOYSA-N 0.000 claims 1
FWRBJTIVZRKTOR-UHFFFAOYSA-N 1-[4-[2-[4-(1-butylpiperidin-4-yl)oxyphenyl]-1-propylbenzimidazol-5-yl]oxy-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C=2N(C3=CC=C(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OC)C=C3N=2)CCC)C=C1 FWRBJTIVZRKTOR-UHFFFAOYSA-N 0.000 claims 1
UQNPEVBBZSZTTD-UHFFFAOYSA-N 1-[4-[4-[6-(1-butylpiperidin-4-yl)oxy-1,3-benzoxazol-2-yl]phenoxy]-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(N=C(O2)C=3C=CC(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OC)=CC=3)C2=C1 UQNPEVBBZSZTTD-UHFFFAOYSA-N 0.000 claims 1
RJMPIGWZUXXIET-UHFFFAOYSA-N 1-[4-[4-[6-(1-butylpiperidin-4-yl)oxy-1,3-benzoxazol-2-yl]phenoxy]phenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(N=C(O2)C=3C=CC(OC=4C=CC(NC(=O)NC(CC)CC)=CC=4)=CC=3)C2=C1 RJMPIGWZUXXIET-UHFFFAOYSA-N 0.000 claims 1
XSLXLXJEDGWQPH-UHFFFAOYSA-N 1-[4-[4-[[4-(1-butylpiperidin-4-yl)oxyphenoxy]methyl]phenoxy]-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC(C=C1)=CC=C1OCC(C=C1)=CC=C1OC1=CC=C(NC(=O)NC(CC)CC)C=C1OC XSLXLXJEDGWQPH-UHFFFAOYSA-N 0.000 claims 1
ZDSPRGPTRLSDRN-UHFFFAOYSA-N 1-[4-[[1-[4-(1-butylpiperidin-4-yl)oxy-3-methylbenzoyl]-2,3-dihydroindol-5-yl]oxy]-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N2C3=CC=C(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OC)C=C3CC2)C=C1C ZDSPRGPTRLSDRN-UHFFFAOYSA-N 0.000 claims 1
QZZWVJVJJNKWEA-UHFFFAOYSA-N 1-[4-[[1-[4-(1-butylpiperidin-4-yl)oxybenzoyl]-2,3-dihydroindol-5-yl]oxy]-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N2C3=CC=C(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OC)C=C3CC2)C=C1 QZZWVJVJJNKWEA-UHFFFAOYSA-N 0.000 claims 1
DZSJTEDUSCSHRM-UHFFFAOYSA-N 1-[4-[[4-[4-(1-butylpiperidin-4-yl)oxybenzoyl]-2,3-dihydro-1,4-benzoxazin-7-yl]oxy]phenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N2C3=CC=C(OC=4C=CC(NC(=O)NC(CC)CC)=CC=4)C=C3OCC2)C=C1 DZSJTEDUSCSHRM-UHFFFAOYSA-N 0.000 claims 1
WPDNYXYSBFGQCI-UHFFFAOYSA-N 1-[4-[[5-[4-(1-butylpiperidin-4-yl)oxybenzoyl]-3,4-dihydro-2h-1,5-benzoxazepin-8-yl]oxy]-3-methoxyphenyl]-3-pentan-3-ylurea Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N2C3=CC=C(OC=4C(=CC(NC(=O)NC(CC)CC)=CC=4)OC)C=C3OCCC2)C=C1 WPDNYXYSBFGQCI-UHFFFAOYSA-N 0.000 claims 1
125000004899 1-ethylpropylamino group Chemical group C(C)C(CC)N* 0.000 claims 1
MGZGPQCRWVOGFE-UHFFFAOYSA-N 2,4-dihydro-1h-isoquinolin-3-one Chemical compound C1=CC=C2CNC(=O)CC2=C1 MGZGPQCRWVOGFE-UHFFFAOYSA-N 0.000 claims 1
XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 claims 1
CZDNSYLCKAIQMT-UHFFFAOYSA-N 2-[2-(4-hydroxypiperidin-1-yl)ethyl]-n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-1-benzofuran-6-carboxamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=C(C=C(CCN2CCC(O)CC2)O2)C2=C1 CZDNSYLCKAIQMT-UHFFFAOYSA-N 0.000 claims 1
MWBXSXMLUBMZMY-UHFFFAOYSA-N 2-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C(C)C(CC)NC(NC1=CC=C(OC2=C(C=C(C=C2)C2=C(C(=O)N)C=CC=C2)C)C=C1)=O MWBXSXMLUBMZMY-UHFFFAOYSA-N 0.000 claims 1
GPIHAMGITSGJJB-UHFFFAOYSA-N 2-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C(C)C(CC)NC(NC1=CC(=C(OC2=CC=C(C=C2)C2=C(C(=O)N)C=CC=C2)C=C1)OC)=O GPIHAMGITSGJJB-UHFFFAOYSA-N 0.000 claims 1
NQARMZXRWIQPJW-UHFFFAOYSA-N 2-[4-[4-[[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]carbamoyl]phenoxy]piperidin-1-yl]acetic acid Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CC(O)=O)CC1 NQARMZXRWIQPJW-UHFFFAOYSA-N 0.000 claims 1
JYGPQAFNYZAXJL-UHFFFAOYSA-N 2-[4-[[4-[3-(4-hydroxypiperidin-1-yl)propoxy]benzoyl]amino]phenoxy]-n-methyl-5-(pentan-3-ylcarbamoylamino)benzamide Chemical compound CNC(=O)C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OCCCN1CCC(O)CC1 JYGPQAFNYZAXJL-UHFFFAOYSA-N 0.000 claims 1
IONQMUJDLWMKMT-UHFFFAOYSA-N 2-[4-[[4-[acetyl-[3-(diethylamino)propyl]amino]benzoyl]amino]phenoxy]-n-methyl-5-(pentan-3-ylcarbamoylamino)benzamide Chemical compound CNC(=O)C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(CCCN(CC)CC)C(C)=O)C=C1 IONQMUJDLWMKMT-UHFFFAOYSA-N 0.000 claims 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
KULOWKWOJACDFR-UHFFFAOYSA-N 3-[(4-hydroxypiperidin-1-yl)methyl]-n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-1-propan-2-ylindole-6-carboxamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=C(C(CN2CCC(O)CC2)=CN2C(C)C)C2=C1 KULOWKWOJACDFR-UHFFFAOYSA-N 0.000 claims 1
WYXDGYXAOVFBDC-UHFFFAOYSA-N 3-acetyl-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-1-(2-piperidin-1-ylethyl)indole-5-carboxamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C1=CC=C(N(CCN2CCCCC2)C=C2C(C)=O)C2=C1 WYXDGYXAOVFBDC-UHFFFAOYSA-N 0.000 claims 1
GYLMCBOAXJVARF-UHFFFAOYSA-N 3-azabicyclo[2.2.1]heptane Chemical compound C1C2CCC1NC2 GYLMCBOAXJVARF-UHFFFAOYSA-N 0.000 claims 1
KPUSZZFAYGWAHZ-UHFFFAOYSA-N 3-azabicyclo[2.2.2]octane Chemical compound C1CC2CCC1NC2 KPUSZZFAYGWAHZ-UHFFFAOYSA-N 0.000 claims 1
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 1
CJQGAUMARIXBTE-UHFFFAOYSA-N 3-methyl-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-1-(2-piperidin-1-ylethyl)indole-5-carboxamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C1=CC=C(N(CCN2CCCCC2)C=C2C)C2=C1 CJQGAUMARIXBTE-UHFFFAOYSA-N 0.000 claims 1
FTAHXMZRJCZXDL-UHFFFAOYSA-N 3-piperideine Chemical compound C1CC=CCN1 FTAHXMZRJCZXDL-UHFFFAOYSA-N 0.000 claims 1
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
JINJVONLRLXIBZ-UHFFFAOYSA-N 4-(1-benzylpiperidin-4-yl)oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CC=2C=CC=CC=2)CC1 JINJVONLRLXIBZ-UHFFFAOYSA-N 0.000 claims 1
FGVGVIASMFIXPC-UHFFFAOYSA-N 4-(1-benzylpiperidin-4-yl)oxy-n-[4-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CC=2C=CC=CC=2)CC1 FGVGVIASMFIXPC-UHFFFAOYSA-N 0.000 claims 1
CPZUCPGMFKUONU-UHFFFAOYSA-N 4-(1-benzylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CC=2C=CC=CC=2)CC1 CPZUCPGMFKUONU-UHFFFAOYSA-N 0.000 claims 1
AVUFIEPQKCEWMR-UHFFFAOYSA-N 4-(1-benzylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CC=2C=CC=CC=2)CC1 AVUFIEPQKCEWMR-UHFFFAOYSA-N 0.000 claims 1
LYQVLHHKKUORGT-UHFFFAOYSA-N 4-(1-benzylpiperidin-4-yl)oxy-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1=C(F)C(NC(=O)NC(CC)CC)=CC(OC)=C1OC(C=C1)=CC=C1NC(=O)C(C=C1C)=CC=C1OC1CCN(CC=2C=CC=CC=2)CC1 LYQVLHHKKUORGT-UHFFFAOYSA-N 0.000 claims 1
RWAYWZZHWXFOQT-UHFFFAOYSA-N 4-(1-benzylpiperidin-4-yl)oxy-n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CC=2C=CC=CC=2)CC1 RWAYWZZHWXFOQT-UHFFFAOYSA-N 0.000 claims 1
DGRBQWCUACUGPB-UHFFFAOYSA-N 4-(1-butan-2-ylpiperidin-4-yl)oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)CC)CC1 DGRBQWCUACUGPB-UHFFFAOYSA-N 0.000 claims 1
VONGLEDCGUVQBY-UHFFFAOYSA-N 4-(1-butan-2-ylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)CC)CC1 VONGLEDCGUVQBY-UHFFFAOYSA-N 0.000 claims 1
ASUZZLAVJYBLMU-UHFFFAOYSA-N 4-(1-butyl-3,6-dihydro-2h-pyridin-4-yl)-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]benzamide Chemical compound C1N(CCCC)CCC(C=2C=CC(=CC=2)C(=O)NC=2C=C(C)C(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)=C1 ASUZZLAVJYBLMU-UHFFFAOYSA-N 0.000 claims 1
HJCTZAFCCZTIOB-UHFFFAOYSA-N 4-(1-butyl-3,6-dihydro-2h-pyridin-4-yl)-n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]benzamide Chemical compound C1N(CCCC)CCC(C=2C=CC(=CC=2)C(=O)NC=2SC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)COC)=CN=2)=C1 HJCTZAFCCZTIOB-UHFFFAOYSA-N 0.000 claims 1
BSHDFAUKDMXMPG-UHFFFAOYSA-N 4-(1-butyl-3-fluoropiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound FC1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 BSHDFAUKDMXMPG-UHFFFAOYSA-N 0.000 claims 1
BYPMIYVSLZWOMH-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-2,5-difluoro-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1F BYPMIYVSLZWOMH-UHFFFAOYSA-N 0.000 claims 1
MUMPCRJXXWNRSH-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-2,5-difluoro-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1F MUMPCRJXXWNRSH-UHFFFAOYSA-N 0.000 claims 1
UONOCCVXISEIOH-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-2-chloro-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC(C=C1Cl)=CC=C1C(=O)NC(C=C1)=CC=C1OC1=CC=C(NC(=O)NC(CC)CC)C=C1OC UONOCCVXISEIOH-UHFFFAOYSA-N 0.000 claims 1
BVAOHDFTSCLRPU-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-2-fluoro-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC(C=C1F)=CC=C1C(=O)NC(C=C1)=CC=C1OC1=CC=C(NC(=O)NC(CC)CC)C=C1OC BVAOHDFTSCLRPU-UHFFFAOYSA-N 0.000 claims 1
DUNXKCVUAFDENW-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-2-fluoro-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-5-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1C DUNXKCVUAFDENW-UHFFFAOYSA-N 0.000 claims 1
SVPPZMBHWPGQLW-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-3-chloro-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1Cl SVPPZMBHWPGQLW-UHFFFAOYSA-N 0.000 claims 1
HDUXAQCADSTRBE-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-3-chloro-n-ethyl-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1Cl HDUXAQCADSTRBE-UHFFFAOYSA-N 0.000 claims 1
JXLBXYNZQJKPFL-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-3-methoxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1OC JXLBXYNZQJKPFL-UHFFFAOYSA-N 0.000 claims 1
YEHQJXDUMFUVPZ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-3-methyl-n-[4-[4-(pentan-3-ylcarbamoylamino)-2-propoxyphenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCCC)=CC=2)C=C1C YEHQJXDUMFUVPZ-UHFFFAOYSA-N 0.000 claims 1
VEMVDHZAKJYCKH-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-3-methyl-n-[4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1C VEMVDHZAKJYCKH-UHFFFAOYSA-N 0.000 claims 1
PEIYXBRLIJUPPQ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-(2-hydroxyethyl)-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCO)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 PEIYXBRLIJUPPQ-UHFFFAOYSA-N 0.000 claims 1
VGCBWKYEOUETMG-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-(2-methoxyethyl)-3-methyl-n-[4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCOC)C=2C=CC(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1C VGCBWKYEOUETMG-UHFFFAOYSA-N 0.000 claims 1
ROSFHFSMFJXVJP-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-(2-methoxyethyl)-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCOC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1C ROSFHFSMFJXVJP-UHFFFAOYSA-N 0.000 claims 1
URBVEYNMNJJTBB-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-(2-methoxyethyl)-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCOC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 URBVEYNMNJJTBB-UHFFFAOYSA-N 0.000 claims 1
DGRSCDJBQWNMDJ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2,5-dimethyl-4-[4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C=CC(NC(=O)NC(C)C)=CC=3)=C(C)C=2)C)C=C1 DGRSCDJBQWNMDJ-UHFFFAOYSA-N 0.000 claims 1
VDZKSQXTWRAGMT-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-fluoro-4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)F)C=C1C VDZKSQXTWRAGMT-UHFFFAOYSA-N 0.000 claims 1
CJVNDRDZYCWROM-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-fluoro-4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)F)C=C1 CJVNDRDZYCWROM-UHFFFAOYSA-N 0.000 claims 1
QBWDWTXHNPLVDX-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-fluoro-4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C=C(F)C(NC(=O)NC(CC)CC)=CC=3)=CC=2)F)C=C1C QBWDWTXHNPLVDX-UHFFFAOYSA-N 0.000 claims 1
KAFSOBPQEKCJFZ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-fluoro-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methoxybenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)F)C=C1OC KAFSOBPQEKCJFZ-UHFFFAOYSA-N 0.000 claims 1
VZAJUPUWKRLYEB-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-fluoro-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)F)C=C1C VZAJUPUWKRLYEB-UHFFFAOYSA-N 0.000 claims 1
XIUCAZURIYIENF-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-fluoro-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)F)C=C1 XIUCAZURIYIENF-UHFFFAOYSA-N 0.000 claims 1
ZOFIUQCOSMJWNK-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-methoxy-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)OC)C=C1C ZOFIUQCOSMJWNK-UHFFFAOYSA-N 0.000 claims 1
RVWMTBJXYDRHEG-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[2-methoxy-4-[4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C=CC(NC(=O)NC(C)C)=CC=3)=CC=2)OC)C=C1 RVWMTBJXYDRHEG-UHFFFAOYSA-N 0.000 claims 1
ZNGOWSQAUVDYBB-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[3,5-dimethyl-4-[4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(C)C(OC=3C=CC(NC(=O)NC(C)C)=CC=3)=C(C)C=2)C=C1 ZNGOWSQAUVDYBB-UHFFFAOYSA-N 0.000 claims 1
MVURYMBQJCLHGO-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[3-(pentan-3-ylcarbamoylamino)-5,6-dihydrobenzo[b][1]benzoxepin-8-yl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C3CCC4=CC(NC(=O)NC(CC)CC)=CC=C4OC3=CC=2)C=C1 MVURYMBQJCLHGO-UHFFFAOYSA-N 0.000 claims 1
TYVCJXCHLUBQKV-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[3-[4-(dimethylaminocarbamoylamino)-2-methoxyphenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(OC=3C(=CC(NC(=O)NN(C)C)=CC=3)OC)C=CC=2)C=C1 TYVCJXCHLUBQKV-UHFFFAOYSA-N 0.000 claims 1
ZPMBGLGMPZULLY-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(C)C(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1 ZPMBGLGMPZULLY-UHFFFAOYSA-N 0.000 claims 1
XYHGYDPZHXJOOB-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2,5-difluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2,5-difluorobenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)F)=CC=2)C=C1F XYHGYDPZHXJOOB-UHFFFAOYSA-N 0.000 claims 1
KAPQDAUTXKVGMY-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2,5-difluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)F)=CC=2)C=C1C KAPQDAUTXKVGMY-UHFFFAOYSA-N 0.000 claims 1
XQOCZYXKNRQHKJ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2,5-difluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)F)=CC=2)C=C1 XQOCZYXKNRQHKJ-UHFFFAOYSA-N 0.000 claims 1
XBCRLYKCQSGRQZ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(C)C(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)COC)=CC=2)C=C1 XBCRLYKCQSGRQZ-UHFFFAOYSA-N 0.000 claims 1
WKRPNMCZPQXZGK-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)COC)=CC=2)C=C1 WKRPNMCZPQXZGK-UHFFFAOYSA-N 0.000 claims 1
QNJKKYYVDBABIS-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-chloro-4-(pentan-3-ylcarbamoylamino)phenoxy]-2-fluorophenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)Cl)=CC=2)F)C=C1C QNJKKYYVDBABIS-UHFFFAOYSA-N 0.000 claims 1
SGKQKEFQSTUMLM-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-chloro-4-(pentan-3-ylcarbamoylamino)phenoxy]-2-fluorophenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)Cl)=CC=2)F)C=C1 SGKQKEFQSTUMLM-UHFFFAOYSA-N 0.000 claims 1
ZJTRVBXDEDNBQB-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-chloro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)Cl)=CC=2)C=C1 ZJTRVBXDEDNBQB-UHFFFAOYSA-N 0.000 claims 1
SFJIPJBWVWUCPV-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-2-fluorophenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)F)C=C1C SFJIPJBWVWUCPV-UHFFFAOYSA-N 0.000 claims 1
PBRFSLVRILTYLA-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-2-fluorophenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C(=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)F)C=C1 PBRFSLVRILTYLA-UHFFFAOYSA-N 0.000 claims 1
SYTLJAXMLIVHAI-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2,5-difluorobenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1F SYTLJAXMLIVHAI-UHFFFAOYSA-N 0.000 claims 1
XLYWSAPGKJDXSR-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2-fluoro-5-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1C XLYWSAPGKJDXSR-UHFFFAOYSA-N 0.000 claims 1
YTRNZICPYNKYTG-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methoxybenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1OC YTRNZICPYNKYTG-UHFFFAOYSA-N 0.000 claims 1
XBNFPGMXYCGPQM-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1C XBNFPGMXYCGPQM-UHFFFAOYSA-N 0.000 claims 1
HRBDBNTXQXWBDW-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(2-methoxyethyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCOC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 HRBDBNTXQXWBDW-UHFFFAOYSA-N 0.000 claims 1
NUYRPDAMJXPRCO-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 NUYRPDAMJXPRCO-UHFFFAOYSA-N 0.000 claims 1
LIWMLJKBXFYZNK-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]piperidine-1-carboxamide Chemical compound C1CN(CCCC)CCC1OC1CCN(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)CC1 LIWMLJKBXFYZNK-UHFFFAOYSA-N 0.000 claims 1
GJFMRAHCTNFZFA-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-5-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2-fluoro-5-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OCC)=CC=2)C=C1C GJFMRAHCTNFZFA-UHFFFAOYSA-N 0.000 claims 1
SYLHZIKXOVLLLU-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethoxy-5-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OCC)=CC=2)C=C1C SYLHZIKXOVLLLU-UHFFFAOYSA-N 0.000 claims 1
GBULEWNCJWTITI-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-ethyl-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)CC)=CC=2)C=C1 GBULEWNCJWTITI-UHFFFAOYSA-N 0.000 claims 1
WRFYOAWVHWMNHE-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)F)=CC=2)C=C1 WRFYOAWVHWMNHE-UHFFFAOYSA-N 0.000 claims 1
XCJIASCWKCMONP-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(C)C(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 XCJIASCWKCMONP-UHFFFAOYSA-N 0.000 claims 1
AYBMFMXAZSHUDU-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC(C=C1C)=CC=C1C(=O)NC(C=C1)=CC=C1OC1=CC=C(NC(=O)NC(CC)CC)C=C1OC AYBMFMXAZSHUDU-UHFFFAOYSA-N 0.000 claims 1
HPNYZHCLCOXJSH-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3,5-dimethylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=C(C)C=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1C HPNYZHCLCOXJSH-UHFFFAOYSA-N 0.000 claims 1
SBGDIVSDVGWZPD-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1C SBGDIVSDVGWZPD-UHFFFAOYSA-N 0.000 claims 1
GDSJVUOGBDCTTR-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(1-methoxypropan-2-yl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(C(C)COC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 GDSJVUOGBDCTTR-UHFFFAOYSA-N 0.000 claims 1
NUZMEPMIHGYXAY-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(2,2,2-trifluoroethyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC(F)(F)F)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 NUZMEPMIHGYXAY-UHFFFAOYSA-N 0.000 claims 1
OKXBJPFVXDWQCK-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(2-methoxypropyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC(C)OC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 OKXBJPFVXDWQCK-UHFFFAOYSA-N 0.000 claims 1
NYGQODCRDUNUGG-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(2-methylpropyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC(C)C)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 NYGQODCRDUNUGG-UHFFFAOYSA-N 0.000 claims 1
TYEVBPSOPPXZDA-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(3,3,3-trifluoropropyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCC(F)(F)F)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 TYEVBPSOPPXZDA-UHFFFAOYSA-N 0.000 claims 1
VUEMEAXRNCMQPZ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(3-methoxypropyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCCOC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 VUEMEAXRNCMQPZ-UHFFFAOYSA-N 0.000 claims 1
KWVNECGFOSSAOY-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(4,4,4-trifluorobutyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCCC(F)(F)F)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 KWVNECGFOSSAOY-UHFFFAOYSA-N 0.000 claims 1
ORLRWXZFNSLLHL-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(oxan-4-yl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(C2CCOCC2)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 ORLRWXZFNSLLHL-UHFFFAOYSA-N 0.000 claims 1
IXWINLQGPUSAHW-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(oxolan-2-ylmethyl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC2OCCC2)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 IXWINLQGPUSAHW-UHFFFAOYSA-N 0.000 claims 1
VLPZKEGLHGCFEO-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(oxolan-3-yl)benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(C2COCC2)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 VLPZKEGLHGCFEO-UHFFFAOYSA-N 0.000 claims 1
LMVMNKSCSCGTJG-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methoxy-4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(C)C)=CC=3)OC)=CC=2)C=C1 LMVMNKSCSCGTJG-UHFFFAOYSA-N 0.000 claims 1
FUQXMGWTHZZGGF-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[2-methyl-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)C)=CC=2)C=C1 FUQXMGWTHZZGGF-UHFFFAOYSA-N 0.000 claims 1
SYXMEFWBGVPEFH-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[3-(hydroxymethyl)-4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=C(CO)C(NC(=O)NC(C)C)=CC=3)=CC=2)C=C1 SYXMEFWBGVPEFH-UHFFFAOYSA-N 0.000 claims 1
ITMLVJFERQQABL-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(C)C(OC=3C=C(F)C(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1 ITMLVJFERQQABL-UHFFFAOYSA-N 0.000 claims 1
QGZVEFXYTCOMDN-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methoxybenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=C(F)C(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1OC QGZVEFXYTCOMDN-UHFFFAOYSA-N 0.000 claims 1
ITZCLHXHZFYJHX-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=C(F)C(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1C ITZCLHXHZFYJHX-UHFFFAOYSA-N 0.000 claims 1
DYPGHHCNOSMWBU-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=C(F)C(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1 DYPGHHCNOSMWBU-UHFFFAOYSA-N 0.000 claims 1
MOPXYSCFOKGEEF-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[3-methoxy-4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=C(OC)C(NC(=O)NC(C)C)=CC=3)=CC=2)C=C1 MOPXYSCFOKGEEF-UHFFFAOYSA-N 0.000 claims 1
DIFLHHSBHKYWKB-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-(dimethylaminocarbamoylamino)phenoxy]-3-(methoxymethyl)phenyl]-3-methoxybenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(COC)C(OC=3C=CC(NC(=O)NN(C)C)=CC=3)=CC=2)C=C1OC DIFLHHSBHKYWKB-UHFFFAOYSA-N 0.000 claims 1
YVXJZLNZIMCTQW-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-(dimethylaminocarbamoylamino)phenoxy]-3-(methoxymethyl)phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(COC)C(OC=3C=CC(NC(=O)NN(C)C)=CC=3)=CC=2)C=C1C YVXJZLNZIMCTQW-UHFFFAOYSA-N 0.000 claims 1
YPHCLYRKHGYOLI-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-(pentan-3-ylcarbamoylamino)-2-propan-2-ylphenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)C(C)C)=CC=2)C=C1 YPHCLYRKHGYOLI-UHFFFAOYSA-N 0.000 claims 1
UGNHMNFKESEJNK-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-(pentan-3-ylcarbamoylamino)phenoxy]-3-(trifluoromethyl)phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=C(C(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)C(F)(F)F)C=C1 UGNHMNFKESEJNK-UHFFFAOYSA-N 0.000 claims 1
JYIOAPYSALPRKD-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1 JYIOAPYSALPRKD-UHFFFAOYSA-N 0.000 claims 1
PQFHFEWCALHXSU-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C=CC(NC(=O)NC(C)C)=CC=3)=CC=2)C=C1 PQFHFEWCALHXSU-UHFFFAOYSA-N 0.000 claims 1
YHFPOBGSSUURGF-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-(propan-2-ylcarbamoylamino)phenyl]sulfanylphenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(SC=3C=CC(NC(=O)NC(C)C)=CC=3)=CC=2)C=C1 YHFPOBGSSUURGF-UHFFFAOYSA-N 0.000 claims 1
AISSVXAWLNLHDD-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[4-[[2-(dimethylamino)acetyl]amino]-2-methoxyphenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)CN(C)C)=CC=3)OC)=CC=2)C=C1 AISSVXAWLNLHDD-UHFFFAOYSA-N 0.000 claims 1
MGWAUTHWSRRJPC-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[5-fluoro-2-methoxy-4-(1-methoxybutan-2-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)COC)=C(F)C=3)OC)=CC=2)C=C1C MGWAUTHWSRRJPC-UHFFFAOYSA-N 0.000 claims 1
PKKWHNHOIOWDPB-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1C PKKWHNHOIOWDPB-UHFFFAOYSA-N 0.000 claims 1
OOZLXYXTLVYKIS-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(2-methoxyethyl)-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CCOC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1C OOZLXYXTLVYKIS-UHFFFAOYSA-N 0.000 claims 1
JLHARIGFOPCLNN-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1 JLHARIGFOPCLNN-UHFFFAOYSA-N 0.000 claims 1
BXPVDHIZGWYUSG-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[5-fluoro-2-methoxy-4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(C)C)=C(F)C=3)OC)=CC=2)C=C1C BXPVDHIZGWYUSG-UHFFFAOYSA-N 0.000 claims 1
NVZVPFAQDXKTHJ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[4-[[4-(propan-2-ylcarbamoylamino)phenyl]methyl]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(CC=3C=CC(NC(=O)NC(C)C)=CC=3)=CC=2)C=C1 NVZVPFAQDXKTHJ-UHFFFAOYSA-N 0.000 claims 1
XZIGELPPZXBTCH-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[5-[2-(ethoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2SC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)COCC)=CN=2)C=C1 XZIGELPPZXBTCH-UHFFFAOYSA-N 0.000 claims 1
MLYFBLSRMGYQRK-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2SC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)COC)=CN=2)C=C1 MLYFBLSRMGYQRK-UHFFFAOYSA-N 0.000 claims 1
ZVUPRKMRSLBISZ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[5-[2-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2SC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)F)=CN=2)C=C1 ZVUPRKMRSLBISZ-UHFFFAOYSA-N 0.000 claims 1
UQRYDOGITUJXCR-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)NC=2SC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CN=2)C=C1 UQRYDOGITUJXCR-UHFFFAOYSA-N 0.000 claims 1
QOMJIWLMHFJFPP-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-ethyl-3-methoxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1OC QOMJIWLMHFJFPP-UHFFFAOYSA-N 0.000 claims 1
IWGDXPQCXQDSBZ-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-ethyl-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1C IWGDXPQCXQDSBZ-UHFFFAOYSA-N 0.000 claims 1
FPJJKNSXYSXKNX-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-ethyl-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 FPJJKNSXYSXKNX-UHFFFAOYSA-N 0.000 claims 1
LFZNLWCIOZNFFI-UHFFFAOYSA-N 4-(1-butylpiperidin-4-yl)oxy-n-ethyl-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCCC)CCC1OC1=CC=C(C(=O)N(CC)C=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1C LFZNLWCIOZNFFI-UHFFFAOYSA-N 0.000 claims 1
VPXFIZRTCFCHTR-UHFFFAOYSA-N 4-(1-butylpyrrolidin-3-yl)oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1N(CCCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 VPXFIZRTCFCHTR-UHFFFAOYSA-N 0.000 claims 1
BZBRUIVBZMJZLQ-UHFFFAOYSA-N 4-(1-cyclobutylpiperidin-4-yl)oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C2CCC2)CC1 BZBRUIVBZMJZLQ-UHFFFAOYSA-N 0.000 claims 1
OBSQBSQXEXXZTL-UHFFFAOYSA-N 4-(1-cyclopentylpiperidin-4-yl)oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C2CCCC2)CC1 OBSQBSQXEXXZTL-UHFFFAOYSA-N 0.000 claims 1
LWNUGHZZTYVNCS-UHFFFAOYSA-N 4-(1-cyclopropylpiperidin-4-yl)oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C2CC2)CC1 LWNUGHZZTYVNCS-UHFFFAOYSA-N 0.000 claims 1
GADZXRRNUDZPOU-UHFFFAOYSA-N 4-(1-ethyl-3,6-dihydro-2h-pyridin-4-yl)-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C1=CC=C(C=2CCN(CC)CC=2)C=C1 GADZXRRNUDZPOU-UHFFFAOYSA-N 0.000 claims 1
CFWSGLDWVOEREG-UHFFFAOYSA-N 4-(4-butyl-1,4-diazepan-1-yl)-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCCN1C1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 CFWSGLDWVOEREG-UHFFFAOYSA-N 0.000 claims 1
ZRJUHKOPGLUHEH-UHFFFAOYSA-N 4-(4-butyl-1,4-diazepan-1-yl)-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCCN1C1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 ZRJUHKOPGLUHEH-UHFFFAOYSA-N 0.000 claims 1
JMCKGBWZTNUCHV-UHFFFAOYSA-N 4-(4-butyl-1,4-diazepan-1-yl)-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCCN1C1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1 JMCKGBWZTNUCHV-UHFFFAOYSA-N 0.000 claims 1
BQSHOHKYTKCXPT-UHFFFAOYSA-N 4-(4-butylpiperazin-1-yl)-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2-fluoro-5-methylbenzamide Chemical compound C1CN(CCCC)CCN1C1=CC(F)=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1C BQSHOHKYTKCXPT-UHFFFAOYSA-N 0.000 claims 1
IKHRUXPEYUBTBU-UHFFFAOYSA-N 4-(4-butylpiperazin-1-yl)-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCN1C1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 IKHRUXPEYUBTBU-UHFFFAOYSA-N 0.000 claims 1
PRVNOWRLOOUYAG-UHFFFAOYSA-N 4-(4-ethylpiperazine-1-carbonyl)-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C1=CC=C(C(=O)N2CCN(CC)CC2)C=C1 PRVNOWRLOOUYAG-UHFFFAOYSA-N 0.000 claims 1
UOZHOXNBJUWQER-UHFFFAOYSA-N 4-[(1-benzylpiperidin-4-yl)-methylamino]-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(C)C2CCN(CC=3C=CC=CC=3)CC2)C=C1 UOZHOXNBJUWQER-UHFFFAOYSA-N 0.000 claims 1
SONUAIKJYBKLAG-UHFFFAOYSA-N 4-[(1-benzylpiperidin-4-yl)amino]-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1NC1CCN(CC=2C=CC=CC=2)CC1 SONUAIKJYBKLAG-UHFFFAOYSA-N 0.000 claims 1
YQYJFFXGCJHPLR-UHFFFAOYSA-N 4-[(1-butylpiperidin-4-yl)-methylamino]-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1N(C)C1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 YQYJFFXGCJHPLR-UHFFFAOYSA-N 0.000 claims 1
FERWIRRKAZCBLG-UHFFFAOYSA-N 4-[(1-butylpiperidin-4-yl)-methylamino]-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1N(C)C1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 FERWIRRKAZCBLG-UHFFFAOYSA-N 0.000 claims 1
QASRHWVUQZXSBK-UHFFFAOYSA-N 4-[(1-butylpiperidin-4-yl)-methylamino]-n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1N(C)C1=CC=C(C(=O)NC=2C=CC(OC=3C=C(F)C(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1 QASRHWVUQZXSBK-UHFFFAOYSA-N 0.000 claims 1
CEKINWILKSPEMJ-UHFFFAOYSA-N 4-[(1-butylpiperidin-4-yl)-methylamino]-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1N(C)C1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1 CEKINWILKSPEMJ-UHFFFAOYSA-N 0.000 claims 1
JQSALQCXJMNEMX-UHFFFAOYSA-N 4-[(1-butylpiperidin-4-yl)amino]-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCCC)CCC1NC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OCC)=CC=2)C=C1 JQSALQCXJMNEMX-UHFFFAOYSA-N 0.000 claims 1
UHTRVMXMFFCGNX-UHFFFAOYSA-N 4-[1-(1-hydroxybutan-2-yl)piperidin-4-yl]oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(CC)CO)CC1 UHTRVMXMFFCGNX-UHFFFAOYSA-N 0.000 claims 1
CTUIAOGXUAIYJC-UHFFFAOYSA-N 4-[1-(2-ethoxyethyl)piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CCOCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 CTUIAOGXUAIYJC-UHFFFAOYSA-N 0.000 claims 1
ZCGYJOCOUFJHMO-UHFFFAOYSA-N 4-[1-(2-ethoxyethyl)piperidin-4-yl]oxy-n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methylbenzamide Chemical compound C1CN(CCOCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=C(F)C=3)OC)=CC=2)C=C1C ZCGYJOCOUFJHMO-UHFFFAOYSA-N 0.000 claims 1
WSQSGEBZRQLGEX-UHFFFAOYSA-N 4-[1-(2-ethylbutyl)piperidin-4-yl]oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1CN(CC(CC)CC)CCC1OC1=CC=C(C(=O)NC=2C=C(C)C(OC=3C=CC(NC(=O)NC(CC)CC)=CC=3)=CC=2)C=C1 WSQSGEBZRQLGEX-UHFFFAOYSA-N 0.000 claims 1
VZAMIYXUENHJJZ-UHFFFAOYSA-N 4-[1-(2-hydroxyethyl)piperidin-4-yl]oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCO)CC1 VZAMIYXUENHJJZ-UHFFFAOYSA-N 0.000 claims 1
BTHSCLNXNULUPR-UHFFFAOYSA-N 4-[1-(2-hydroxyethyl)piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCO)CC1 BTHSCLNXNULUPR-UHFFFAOYSA-N 0.000 claims 1
CYCQYHSYFMABRB-UHFFFAOYSA-N 4-[1-(2-methoxyethyl)piperidin-4-yl]oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCOC)CC1 CYCQYHSYFMABRB-UHFFFAOYSA-N 0.000 claims 1
ZPPYOSNGWVZNRC-UHFFFAOYSA-N 4-[1-(2-methoxyethyl)piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCOC)CC1 ZPPYOSNGWVZNRC-UHFFFAOYSA-N 0.000 claims 1
NUKKOFPCEDTWJX-UHFFFAOYSA-N 4-[1-(3-hydroxypropyl)piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCCO)CC1 NUKKOFPCEDTWJX-UHFFFAOYSA-N 0.000 claims 1
FTQPJBFSJHCTMQ-UHFFFAOYSA-N 4-[1-(3-hydroxypropyl)piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCCO)CC1 FTQPJBFSJHCTMQ-UHFFFAOYSA-N 0.000 claims 1
YQGXAEMZSRXDCE-UHFFFAOYSA-N 4-[1-(3-methylbutyl)piperidin-4-yl]oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCC(C)C)CC1 YQGXAEMZSRXDCE-UHFFFAOYSA-N 0.000 claims 1
XDQAQZJXHHXBLO-UHFFFAOYSA-N 4-[1-(4-fluorobutyl)piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCCCF)CC1 XDQAQZJXHHXBLO-UHFFFAOYSA-N 0.000 claims 1
PCPPKDKTSWXDEN-UHFFFAOYSA-N 4-[1-(4-hydroxybutyl)piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCCCO)CC1 PCPPKDKTSWXDEN-UHFFFAOYSA-N 0.000 claims 1
LJNUJNKEYXDJQN-UHFFFAOYSA-N 4-[1-(cyclohexylmethyl)piperidin-4-yl]oxy-n-[3-methyl-4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CC2CCCCC2)CC1 LJNUJNKEYXDJQN-UHFFFAOYSA-N 0.000 claims 1
NKTYUBKNUYCOQN-UHFFFAOYSA-N 4-[1-(dimethylamino)piperidin-4-yl]oxy-n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(N(C)C)CC1 NKTYUBKNUYCOQN-UHFFFAOYSA-N 0.000 claims 1
LJRIYXMHCSFTDJ-UHFFFAOYSA-N 4-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(=O)CN(C)C)CC1 LJRIYXMHCSFTDJ-UHFFFAOYSA-N 0.000 claims 1
XYJXOEVTTSWJOB-UHFFFAOYSA-N 4-[1-[2-(dimethylamino)ethyl]piperidin-4-yl]oxy-n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCN(C)C)CC1 XYJXOEVTTSWJOB-UHFFFAOYSA-N 0.000 claims 1
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WXPHCGUXDVYQBS-UHFFFAOYSA-N n-[4-[2-(methylcarbamoyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-1-(2-piperidin-1-ylethyl)indole-5-carboxamide Chemical compound CNC(=O)C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(CCN2CCCCC2)C=C2)C2=C1 WXPHCGUXDVYQBS-UHFFFAOYSA-N 0.000 claims 1
UVRISBYKKHACKC-UHFFFAOYSA-N n-[4-[2-(methylcarbamoyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-1-(3-piperidin-1-ylpropyl)indole-5-carboxamide Chemical compound CNC(=O)C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(CCCN2CCCCC2)C=C2)C2=C1 UVRISBYKKHACKC-UHFFFAOYSA-N 0.000 claims 1
HRPGMDVLGQWGIF-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-2-fluorophenyl]-3-methyl-4-(1-methylpiperidin-4-yl)oxybenzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1F)=CC=C1NC(=O)C(C=C1C)=CC=C1OC1CCN(C)CC1 HRPGMDVLGQWGIF-UHFFFAOYSA-N 0.000 claims 1
XGNARZWLEYPJOD-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methyl-4-(1-methylpiperidin-4-yl)oxybenzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1C)=CC=C1OC1CCN(C)CC1 XGNARZWLEYPJOD-UHFFFAOYSA-N 0.000 claims 1
XLYAVFFQVWIUMN-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(4-ethylpiperazin-1-yl)benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N2CCN(CC)CC2)C=C1 XLYAVFFQVWIUMN-UHFFFAOYSA-N 0.000 claims 1
CPQHIJUNQASEAE-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N2CCN(C)CCC2)C=C1 CPQHIJUNQASEAE-UHFFFAOYSA-N 0.000 claims 1
VLNZAFKUNMPMPZ-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(piperidin-4-ylamino)benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1NC1CCNCC1 VLNZAFKUNMPMPZ-UHFFFAOYSA-N 0.000 claims 1
CQHURGMMHVEBCX-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[(1-ethylpiperidin-4-yl)-methylamino]benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(C)C2CCN(CC)CC2)C=C1 CQHURGMMHVEBCX-UHFFFAOYSA-N 0.000 claims 1
OLXHZWLRTSFQEX-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[(1-ethylpiperidin-4-yl)amino]benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1NC1CCN(CC)CC1 OLXHZWLRTSFQEX-UHFFFAOYSA-N 0.000 claims 1
MTIMREUGPBMZRG-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[(4-ethylpiperazin-1-yl)methyl]benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1CN1CCN(CC)CC1 MTIMREUGPBMZRG-UHFFFAOYSA-N 0.000 claims 1
UPVSQKXGVHOGCO-UHFFFAOYSA-N n-[4-[2-ethoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[methyl(piperidin-4-yl)amino]benzamide Chemical compound CCOC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(C)C2CCNCC2)C=C1 UPVSQKXGVHOGCO-UHFFFAOYSA-N 0.000 claims 1
HIGBOGGHQOEOCC-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]-1-(3-piperidin-1-ylpropyl)indole-5-carboxamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C1=CC=C(N(CCCN2CCCCC2)C=C2)C2=C1 HIGBOGGHQOEOCC-UHFFFAOYSA-N 0.000 claims 1
CRAANLVBDXZIQF-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]-4-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C1=CC=C(C=2CCN(C)CC=2)C=C1 CRAANLVBDXZIQF-UHFFFAOYSA-N 0.000 claims 1
UJQWYFMKZCMXTE-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]-4-(1-propan-2-yl-3,6-dihydro-2h-pyridin-4-yl)benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C1=CC=C(C=2CCN(CC=2)C(C)C)C=C1 UJQWYFMKZCMXTE-UHFFFAOYSA-N 0.000 claims 1
CMOBCYPQCNOJBR-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)C)CC1 CMOBCYPQCNOJBR-UHFFFAOYSA-N 0.000 claims 1
GJWFHXUDTZLXLG-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]-4-[1-(3-methylbutyl)piperidin-4-yl]oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCC(C)C)CC1 GJWFHXUDTZLXLG-UHFFFAOYSA-N 0.000 claims 1
CZYWVVHGZBXOSA-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]-4-piperidin-4-yloxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCNCC1 CZYWVVHGZBXOSA-UHFFFAOYSA-N 0.000 claims 1
OFNBITKXJXTFJC-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-1-(1-methylpiperidin-4-yl)indole-5-carboxamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(N(C=C2)C3CCN(C)CC3)C2=C1 OFNBITKXJXTFJC-UHFFFAOYSA-N 0.000 claims 1
NYDAXKWANOEOBM-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-2-methyl-3,4-dihydro-1h-[1]benzofuro[3,2-c]pyridine-8-carboxamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(OC2=C3CN(C)CC2)C3=C1 NYDAXKWANOEOBM-UHFFFAOYSA-N 0.000 claims 1
AJOOEGXVGUAQIJ-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(C=2CCN(C)CC=2)C=C1 AJOOEGXVGUAQIJ-UHFFFAOYSA-N 0.000 claims 1
AZXBCGCDZNGESQ-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-methylpiperidin-4-yl)oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C)CC1 AZXBCGCDZNGESQ-UHFFFAOYSA-N 0.000 claims 1
SZCFYBRQLBKLOG-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-pentan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound C1CN(C(C)CCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 SZCFYBRQLBKLOG-UHFFFAOYSA-N 0.000 claims 1
ADGSGHPJXPAZKO-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-propan-2-yl-3,6-dihydro-2h-pyridin-4-yl)benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(C=2CCN(CC=2)C(C)C)C=C1 ADGSGHPJXPAZKO-UHFFFAOYSA-N 0.000 claims 1
UHKNIAZCMVRKIG-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)C)CC1 UHKNIAZCMVRKIG-UHFFFAOYSA-N 0.000 claims 1
KWBIFKAECWJVQX-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-propylpiperidin-4-yl)oxybenzamide Chemical compound C1CN(CCC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(CC)CC)=CC=3)OC)=CC=2)C=C1 KWBIFKAECWJVQX-UHFFFAOYSA-N 0.000 claims 1
XMHRVMSBWWJTHJ-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(2,2,6,6-tetramethylpiperidin-4-yl)oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CC(C)(C)NC(C)(C)C1 XMHRVMSBWWJTHJ-UHFFFAOYSA-N 0.000 claims 1
ZPNMOSOWIZWOPV-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[(1-propan-2-ylpiperidin-4-yl)methoxy]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OCC1CCN(C(C)C)CC1 ZPNMOSOWIZWOPV-UHFFFAOYSA-N 0.000 claims 1
BRWORHLCJQQOHY-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(3,3,3-trifluoropropyl)piperidin-4-yl]oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCC(F)(F)F)CC1 BRWORHLCJQQOHY-UHFFFAOYSA-N 0.000 claims 1
MCGUPVUHQADECY-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(3-methoxypropyl)piperidin-4-yl]oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCCOC)CC1 MCGUPVUHQADECY-UHFFFAOYSA-N 0.000 claims 1
NZMYQNHXZNUJBG-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(3-methylbutyl)piperidin-4-yl]oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCC(C)C)CC1 NZMYQNHXZNUJBG-UHFFFAOYSA-N 0.000 claims 1
VVDCHGRDXKJTHJ-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(4,4,4-trifluorobutyl)piperidin-4-yl]oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCCC(F)(F)F)CC1 VVDCHGRDXKJTHJ-UHFFFAOYSA-N 0.000 claims 1
TXSVHIPGMJQCHW-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(oxan-4-yl)piperidin-4-yl]oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C2CCOCC2)CC1 TXSVHIPGMJQCHW-UHFFFAOYSA-N 0.000 claims 1
KZKXDGASENDEHL-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-[3-(oxan-4-ylamino)propyl]piperidin-4-yl]oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(CCCNC2CCOCC2)CC1 KZKXDGASENDEHL-UHFFFAOYSA-N 0.000 claims 1
IIWLFZWJOMBKEU-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-piperidin-4-yloxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCNCC1 IIWLFZWJOMBKEU-UHFFFAOYSA-N 0.000 claims 1
VHGMNXJBSSOEOQ-UHFFFAOYSA-N n-[4-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-n-(2-methylpropyl)-4-piperidin-4-yloxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC1=CC=C(N(CC(C)C)C(=O)C=2C=CC(OC3CCNCC3)=CC=2)C=C1 VHGMNXJBSSOEOQ-UHFFFAOYSA-N 0.000 claims 1
CLYYHWLVSZMUDL-UHFFFAOYSA-N n-[4-[2-methoxy-4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]-4-(1-propan-2-yl-3,6-dihydro-2h-pyridin-4-yl)benzamide Chemical compound COC1=CC(NC(=O)NC(C)C)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(C=2CCN(CC=2)C(C)C)C=C1 CLYYHWLVSZMUDL-UHFFFAOYSA-N 0.000 claims 1
VUXHYPOHSOEXPH-UHFFFAOYSA-N n-[4-[2-methoxy-4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(2-methylpropyl)-3,6-dihydro-2h-pyridin-4-yl]benzamide Chemical compound COC1=CC(NC(=O)NC(C)C)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(C=2CCN(CC(C)C)CC=2)C=C1 VUXHYPOHSOEXPH-UHFFFAOYSA-N 0.000 claims 1
CCKQOGWHYCVZTA-UHFFFAOYSA-N n-[4-[2-methoxy-5-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound CCC(CC)NC(=O)NC1=CC=C(OC)C(OC=2C=CC(NC(=O)C=3C=C(OC4CCN(CC4)C(C)C)C=CC=3)=CC=2)=C1 CCKQOGWHYCVZTA-UHFFFAOYSA-N 0.000 claims 1
ODPDJDYRGPXZIB-UHFFFAOYSA-N n-[4-[2-methoxy-5-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-propan-2-ylpiperidin-3-yl)oxybenzamide Chemical compound CCC(CC)NC(=O)NC1=CC=C(OC)C(OC=2C=CC(NC(=O)C=3C=CC(OC4CN(CCC4)C(C)C)=CC=3)=CC=2)=C1 ODPDJDYRGPXZIB-UHFFFAOYSA-N 0.000 claims 1
BGNBWJVCSQJQKH-UHFFFAOYSA-N n-[4-[2-methoxy-5-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound CCC(CC)NC(=O)NC1=CC=C(OC)C(OC=2C=CC(NC(=O)C=3C=CC(OC4CCN(CC4)C(C)C)=CC=3)=CC=2)=C1 BGNBWJVCSQJQKH-UHFFFAOYSA-N 0.000 claims 1
BZFFVDAPUMEUNY-UHFFFAOYSA-N n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]-3-methylphenyl]-3-(2-hydroxyethyl)-4-piperidin-4-yloxybenzamide Chemical compound C1=C(F)C(NC(=O)NC(CC)CC)=CC=C1OC(C(=C1)C)=CC=C1NC(=O)C(C=C1CCO)=CC=C1OC1CCNCC1 BZFFVDAPUMEUNY-UHFFFAOYSA-N 0.000 claims 1
PZBPINODIVAYPS-UHFFFAOYSA-N n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methyl-4-(1-methylpiperidin-4-yl)oxybenzamide Chemical compound C1=C(F)C(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1C)=CC=C1OC1CCN(C)CC1 PZBPINODIVAYPS-UHFFFAOYSA-N 0.000 claims 1
BLDRNKYYLFKXGL-UHFFFAOYSA-N n-[4-[3-fluoro-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)benzamide Chemical compound C1=C(F)C(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C1=CC=C(C=2CCN(C)CC=2)C=C1 BLDRNKYYLFKXGL-UHFFFAOYSA-N 0.000 claims 1
RJHVXXCFMVVXTD-UHFFFAOYSA-N n-[4-[4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)C)CC1 RJHVXXCFMVVXTD-UHFFFAOYSA-N 0.000 claims 1
BVKKFUYJOXKDLQ-UHFFFAOYSA-N n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-3-methyl-4-piperidin-4-yloxybenzamide Chemical compound C1=C(F)C(NC(=O)NC(CC)CC)=CC(OC)=C1OC(C=C1)=CC=C1NC(=O)C(C=C1C)=CC=C1OC1CCNCC1 BVKKFUYJOXKDLQ-UHFFFAOYSA-N 0.000 claims 1
FYWXECIQFBXPOK-UHFFFAOYSA-N n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(2-methoxyethyl)piperidin-4-yl]oxy-3-methylbenzamide Chemical compound C1=C(F)C(NC(=O)NC(CC)CC)=CC(OC)=C1OC(C=C1)=CC=C1NC(=O)C(C=C1C)=CC=C1OC1CCN(CCOC)CC1 FYWXECIQFBXPOK-UHFFFAOYSA-N 0.000 claims 1
KONRUKIKLIBOEO-UHFFFAOYSA-N n-[4-[5-fluoro-2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(3-methoxypropyl)piperidin-4-yl]oxy-3-methylbenzamide Chemical compound C1=C(F)C(NC(=O)NC(CC)CC)=CC(OC)=C1OC(C=C1)=CC=C1NC(=O)C(C=C1C)=CC=C1OC1CCN(CCCOC)CC1 KONRUKIKLIBOEO-UHFFFAOYSA-N 0.000 claims 1
ATVMBOFRUAZIEO-UHFFFAOYSA-N n-[4-[5-fluoro-2-methoxy-4-(propan-2-ylcarbamoylamino)phenoxy]phenyl]-4-[1-(3-methoxypropyl)piperidin-4-yl]oxy-3-methylbenzamide Chemical compound C1CN(CCCOC)CCC1OC1=CC=C(C(=O)NC=2C=CC(OC=3C(=CC(NC(=O)NC(C)C)=C(F)C=3)OC)=CC=2)C=C1C ATVMBOFRUAZIEO-UHFFFAOYSA-N 0.000 claims 1
LEQYGJWUJTWIAQ-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-3-(1-propan-2-ylpiperidin-3-yl)oxybenzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=CC(OC2CN(CCC2)C(C)C)=C1 LEQYGJWUJTWIAQ-UHFFFAOYSA-N 0.000 claims 1
UKAUSZWKHFBKFX-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-3-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=CC(OC2CCN(CC2)C(C)C)=C1 UKAUSZWKHFBKFX-UHFFFAOYSA-N 0.000 claims 1
XXFQAUJLEVHSSN-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-(1-propan-2-ylpiperidin-3-yl)oxybenzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OC1CN(C(C)C)CCC1 XXFQAUJLEVHSSN-UHFFFAOYSA-N 0.000 claims 1
CYDNTKGHCHLCBX-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)benzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=C(C2CCN(CC2)C(C)C)C=C1 CYDNTKGHCHLCBX-UHFFFAOYSA-N 0.000 claims 1
JGVRMGLLQHNBOY-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)C)CC1 JGVRMGLLQHNBOY-UHFFFAOYSA-N 0.000 claims 1
JVXZKULDMLJLKU-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-[(1-propan-2-ylpiperidin-3-yl)methoxy]benzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OCC1CN(C(C)C)CCC1 JVXZKULDMLJLKU-UHFFFAOYSA-N 0.000 claims 1
PZVBSUMLDBLOLA-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-[(1-propan-2-ylpiperidin-4-yl)methyl]benzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1CC1CCN(C(C)C)CC1 PZVBSUMLDBLOLA-UHFFFAOYSA-N 0.000 claims 1
IKYOSJQRGCHDTK-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-[(1-propan-2-ylpiperidin-4-ylidene)methyl]benzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1C=C1CCN(C(C)C)CC1 IKYOSJQRGCHDTK-UHFFFAOYSA-N 0.000 claims 1
PFLMQZOAPLJKDP-UHFFFAOYSA-N n-[5-[2-(methoxymethyl)-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-n-methyl-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound COCC1=CC(NC(=O)NC(CC)CC)=CC=C1OC1=CN=C(N(C)C(=O)C=2C=CC(OC3CCN(CC3)C(C)C)=CC=2)S1 PFLMQZOAPLJKDP-UHFFFAOYSA-N 0.000 claims 1
NWTLYGSKNDTPMO-UHFFFAOYSA-N n-[5-[2-[2-(methylamino)-2-oxoethyl]-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-[1-(2-methylpropyl)-3,6-dihydro-2h-pyridin-4-yl]benzamide Chemical compound CNC(=O)CC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=C(C=2CCN(CC(C)C)CC=2)C=C1 NWTLYGSKNDTPMO-UHFFFAOYSA-N 0.000 claims 1
HIPVWNLDIROBHV-UHFFFAOYSA-N n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-1-(2-piperidin-1-ylethyl)indole-5-carboxamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=C(N(CCN2CCCCC2)C=C2)C2=C1 HIPVWNLDIROBHV-UHFFFAOYSA-N 0.000 claims 1
BMKTWILXFOMNGG-UHFFFAOYSA-N n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-2-(2-piperidin-1-ylethyl)-1-propan-2-ylbenzimidazole-5-carboxamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C1=CC=C(N(C(C)C)C(CCN2CCCCC2)=N2)C2=C1 BMKTWILXFOMNGG-UHFFFAOYSA-N 0.000 claims 1
TUTZHFDRKCRPNK-UHFFFAOYSA-N n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-(1-methylpiperidin-4-yl)oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C)CC1 TUTZHFDRKCRPNK-UHFFFAOYSA-N 0.000 claims 1
KKRILSBRRMZZLD-UHFFFAOYSA-N n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)C)CC1 KKRILSBRRMZZLD-UHFFFAOYSA-N 0.000 claims 1
KQCZQUSMZFKEET-UHFFFAOYSA-N n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-(3-piperidin-1-ylpropanoylamino)benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1NC(=O)CCN1CCCCC1 KQCZQUSMZFKEET-UHFFFAOYSA-N 0.000 claims 1
BKUSKBZVKGZKBV-UHFFFAOYSA-N n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-(3-piperidin-1-ylpropoxy)benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OCCCN1CCCCC1 BKUSKBZVKGZKBV-UHFFFAOYSA-N 0.000 claims 1
HDYYTPBLXMNEAP-UHFFFAOYSA-N n-[5-[2-methoxy-4-(pentan-3-ylcarbamoylamino)phenoxy]-1,3-thiazol-2-yl]-4-[(1-propan-2-ylpiperidin-4-yl)methoxy]benzamide Chemical compound COC1=CC(NC(=O)NC(CC)CC)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OCC1CCN(C(C)C)CC1 HDYYTPBLXMNEAP-UHFFFAOYSA-N 0.000 claims 1
OHVNNYYCXSZMRM-UHFFFAOYSA-N n-[5-[4-(dimethylaminocarbamoylamino)-2-[2-(methylamino)-2-oxoethyl]phenoxy]-1,3-thiazol-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Chemical compound CNC(=O)CC1=CC(NC(=O)NN(C)C)=CC=C1OC(S1)=CN=C1NC(=O)C(C=C1)=CC=C1OC1CCN(C(C)C)CC1 OHVNNYYCXSZMRM-UHFFFAOYSA-N 0.000 claims 1
DLHJFHSTADOJAO-UHFFFAOYSA-N n-methyl-5-(pentan-3-ylcarbamoylamino)-2-[4-[[4-(3-piperidin-1-ylpropoxy)benzoyl]amino]phenoxy]benzamide Chemical compound CNC(=O)C1=CC(NC(=O)NC(CC)CC)=CC=C1OC(C=C1)=CC=C1NC(=O)C(C=C1)=CC=C1OCCCN1CCCCC1 DLHJFHSTADOJAO-UHFFFAOYSA-N 0.000 claims 1
150000002926 oxygen Chemical class 0.000 claims 1
125000005704 oxymethylene group Chemical group [H]C([H])([*:2])O[*:1] 0.000 claims 1
IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 claims 1
150000003053 piperidines Chemical class 0.000 claims 1
125000003386 piperidinyl group Chemical group 0.000 claims 1
125000004585 polycyclic heterocycle group Chemical group 0.000 claims 1
230000000069 prophylactic effect Effects 0.000 claims 1
208000020016 psychiatric disease Diseases 0.000 claims 1
150000003235 pyrrolidines Chemical class 0.000 claims 1
125000001453 quaternary ammonium group Chemical group 0.000 claims 1
150000003254 radicals Chemical class 0.000 claims 1
230000001105 regulatory effect Effects 0.000 claims 1
229920006395 saturated elastomer Polymers 0.000 claims 1
230000009329 sexual behaviour Effects 0.000 claims 1
230000001568 sexual effect Effects 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 claims 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
208000019553 vascular disease Diseases 0.000 claims 1
0 CCC(N(C)*)=O Chemical compound CCC(N(C)*)=O 0.000 description 6

JP2008505929A 2005-04-15 2006-04-14 Ｎｐｙ拮抗物質、調製および使用 Pending JP2008538749A (ja)