JP2002520620A5 - - Google Patents

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Publication number
JP2002520620A5
JP2002520620A5 JP2000560456A JP2000560456A JP2002520620A5 JP 2002520620 A5 JP2002520620 A5 JP 2002520620A5 JP 2000560456 A JP2000560456 A JP 2000560456A JP 2000560456 A JP2000560456 A JP 2000560456A JP 2002520620 A5 JP2002520620 A5 JP 2002520620A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2000560456A
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Japanese (ja)
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JP2002520620A (ja
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Priority claimed from US09/115,455 external-priority patent/US6406921B1/en
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Publication of JP2002520620A publication Critical patent/JP2002520620A/ja
Publication of JP2002520620A5 publication Critical patent/JP2002520620A5/ja
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JP2000560456A 1998-07-14 1999-07-14 タンパク質−捕捉剤のアレイおよびその使用方法 Pending JP2002520620A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/115,455 US6406921B1 (en) 1998-07-14 1998-07-14 Protein arrays for high-throughput screening
US09/115,455 1998-07-14
PCT/US1999/015968 WO2000004389A2 (en) 1998-07-14 1999-07-14 Arrays of protein-capture agents and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2002520620A JP2002520620A (ja) 2002-07-09
JP2002520620A5 true JP2002520620A5 (enExample) 2007-05-24

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ID=22361520

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JP2000560449A Pending JP2002520618A (ja) 1998-07-14 1999-07-14 タンパク質のアレイおよびその使用方法
JP2000560456A Pending JP2002520620A (ja) 1998-07-14 1999-07-14 タンパク質−捕捉剤のアレイおよびその使用方法

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JP2000560449A Pending JP2002520618A (ja) 1998-07-14 1999-07-14 タンパク質のアレイおよびその使用方法

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US (14) US6406921B1 (enExample)
EP (2) EP1097380A1 (enExample)
JP (2) JP2002520618A (enExample)
AT (1) ATE397752T1 (enExample)
AU (2) AU773068B2 (enExample)
CA (2) CA2337075A1 (enExample)
DE (1) DE69938867D1 (enExample)
WO (2) WO2000004382A1 (enExample)

Families Citing this family (794)

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Publication number Priority date Publication date Assignee Title
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
ATE270529T1 (de) * 1996-02-16 2004-07-15 Smith & Nephew Inc Transplantatsverankerung
US7041510B2 (en) * 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU4043497A (en) 1996-07-29 1998-02-20 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6368877B1 (en) * 1997-06-25 2002-04-09 Massachusetts Institute Of Technology Self-assembling peptide surfaces for cell patterning and interactions
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
EP1040349B2 (de) 1997-12-17 2012-12-19 Ecole Polytechnique Federale De Lausanne (Epfl) Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
JP2002502038A (ja) * 1998-01-29 2002-01-22 ミラー,サミュエル プロテオーム分析のための高密度アレイ及びその方法及び組成物
EP1060395B1 (en) 1998-02-04 2008-04-30 Invitrogen Corporation Microarrays and uses therefor
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US7132247B1 (en) * 1998-09-17 2006-11-07 Regents Of The University Of Minnesota Composite devices incorporating biological material and methods
US20030190740A1 (en) 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
WO2000022112A1 (en) * 1998-10-13 2000-04-20 The University Of Georgia Research Foundation, Inc. Stabilized bioactive peptides and methods of identification, synthesis and use
BR9915732A (pt) * 1998-11-16 2001-09-04 Genway Biotech Inc Geração de anticorpos usando-se vacinação de polinucleotìdeo em espécie de ave
WO2000033079A1 (en) 1998-11-30 2000-06-08 Nanosphere, Inc. Nanoparticles with polymer shells
US6635311B1 (en) 1999-01-07 2003-10-21 Northwestern University Methods utilizing scanning probe microscope tips and products therefor or products thereby
US6827979B2 (en) 1999-01-07 2004-12-07 Northwestern University Methods utilizing scanning probe microscope tips and products therefor or produced thereby
US7166475B2 (en) * 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
CA2365431A1 (en) * 1999-03-10 2000-09-14 Hui Ge Universal protein array system
AU3867400A (en) * 1999-03-19 2000-10-09 Duke University Methods of using bioelastomers
DE19916867A1 (de) * 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Anordnung und Verfahren zur Herstellung planarer Arrays mit immobilisierten Molekülen
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US7638464B2 (en) * 1999-04-26 2009-12-29 Biocept, Inc. Three dimensional format biochips
EP1181705A2 (en) 1999-04-29 2002-02-27 Ciphergen Biosystems, Inc. Sample holder with hydrophobic coating for gas phase mass spectrometers
JP4493125B2 (ja) * 1999-05-07 2010-06-30 独立行政法人理化学研究所 相互作用するタンパク質の検出方法
US6690399B1 (en) * 1999-05-07 2004-02-10 Tropix, Inc. Data display software for displaying assay results
US7932213B2 (en) * 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
US6573369B2 (en) 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
DE60044923D1 (de) * 1999-05-28 2010-10-21 Yokogawa Electric Corp Biochip-Lesegerät
US7179638B2 (en) * 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
AU6834700A (en) * 1999-08-13 2001-03-13 Zeptosens Ag Device and method for determining multiple analytes
US8111401B2 (en) * 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7167615B1 (en) * 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US7358096B1 (en) * 1999-11-29 2008-04-15 Conopco, Inc. Immobilisation of proteins
WO2001051663A2 (en) * 2000-01-11 2001-07-19 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
EP1294930B1 (en) * 2000-01-13 2011-03-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
JP4730804B2 (ja) * 2000-01-31 2011-07-20 センス・プロテオミック・リミテッド 方法
KR20020064140A (ko) * 2000-01-31 2002-08-07 센스 프로테오믹 리미티드 단백질 발현 어레이의 제작 방법
US7816098B2 (en) 2000-01-31 2010-10-19 Sense Proteomic Limited Methods of making and using a protein array
US20050230315A1 (en) * 2003-01-13 2005-10-20 Regents Of The University Of Michigan Protein microarray system
US20080280771A1 (en) * 2000-02-08 2008-11-13 Regents Of The University Of Michigan Protein MicroarraySystem
US6720157B2 (en) 2000-02-23 2004-04-13 Zyomyx, Inc. Chips having elevated sample surfaces
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6541071B1 (en) * 2000-03-23 2003-04-01 Corning Incorporated Method for fabricating supported bilayer-lipid membranes
CA2404082A1 (en) * 2000-03-27 2001-10-04 Zyomyx, Inc. Site-specific, covalent bioconjugation of proteins
WO2001075150A2 (de) * 2000-03-30 2001-10-11 Infineon Technologies Ag Biosensor, biosensor-array, verfahren zum herstellen einer elektrode eines biosensors, verfahren zum herstellen eines biosensors
WO2001077684A2 (en) * 2000-04-10 2001-10-18 The Scripps Research Institute Proteomic analysis using activity-based probe libraries
US20010041349A1 (en) * 2000-04-17 2001-11-15 Andrew Patron Protein expression system arrays and use in biological screening
DE10020704B4 (de) * 2000-04-27 2006-09-28 Bioref Gmbh Biochip zur Archivierung und labormedizinischen Analyse von biologischem Probenmaterial, Verfahren zu dessen Herstellung sowie dessen Verwendung in diagnostischen Verfahren
AU5951201A (en) * 2000-05-04 2001-11-12 Univ Yale High density protein arrays for screening of protein activity
DE10027397A1 (de) * 2000-06-02 2001-12-13 Graffinity Pharm Design Gmbh Oberfläche zur Immobilisierung von Liganden
US7148058B2 (en) * 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
ATE360207T1 (de) * 2000-06-05 2007-05-15 Novartis Vaccines & Diagnostic Mikroarrays für durchführen von proteomanalyse
JP2004503256A (ja) 2000-06-14 2004-02-05 ビスタジェン インコーポレイテッド 肝臓幹細胞を使用する毒性分類
US20020049152A1 (en) * 2000-06-19 2002-04-25 Zyomyx, Inc. Methods for immobilizing polypeptides
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ATE319087T1 (de) 2000-06-21 2006-03-15 Bioarray Solutions Ltd Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US20020115068A1 (en) * 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
US7062418B2 (en) 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
DE10031587A1 (de) * 2000-06-29 2002-01-10 Basf Ag Dosierung von Suspensionen im Mikromaßstab zur Herstellung von Materialproben in der kombinatorischen Materialforschung sowie deren Prüfung
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7023547B2 (en) * 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
JP3605607B2 (ja) 2000-07-11 2004-12-22 ノースウエスタン ユニバーシティ 銀染色の増強による検出方法
EP1301632A2 (en) * 2000-07-19 2003-04-16 Pointilliste, Inc. Nested sorting and high throughput screening
US20020127623A1 (en) * 2000-07-31 2002-09-12 Maxygen, Inc. Biosensors, reagents and diagnostic applications of directed evolution
WO2002012893A2 (en) * 2000-08-03 2002-02-14 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US7678539B2 (en) 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
US6977155B2 (en) 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
AU2001284899A1 (en) * 2000-08-11 2002-02-25 Qianjin Hu Methods and universal monoclonal antibody array
CA2419544A1 (en) * 2000-08-14 2002-02-21 Surface Logix, Inc. Pathways arrays
WO2002014860A1 (en) 2000-08-15 2002-02-21 Discerna Limited Functional protein arrays
US7008769B2 (en) * 2000-08-15 2006-03-07 Bioforce Nanosciences, Inc. Nanoscale molecular arrayer
CN1494589A (zh) * 2000-08-17 2004-05-05 �������ɭ 方法
US7094568B2 (en) * 2000-08-17 2006-08-22 Sense Proteomic Ltd. Method for producing proteins tagged at the N- or C-terminus
EP1184349A1 (en) * 2000-09-01 2002-03-06 A.S.B.L. Facultes Universitaires Notre-Dame De La Paix Method for obtaining a surface activation of a solid support for building biochips microarrays
US20040115726A1 (en) * 2001-09-14 2004-06-17 Renpei Nagashima Method, system, apparatus and device for discovering and preparing chemical compounds for medical and other uses.
JP5021143B2 (ja) * 2000-09-14 2012-09-05 株式会社リバース・プロテオミクス研究所 医療および他の用途に用いる化合物の発見および創製のための方法
EP2299256A3 (en) 2000-09-15 2012-10-10 California Institute Of Technology Microfabricated crossflow devices and methods
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
US7354721B2 (en) 2000-09-22 2008-04-08 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods, and kits and systems for practicing the same
JP4833498B2 (ja) * 2000-10-03 2011-12-07 ミラリ バイオサイエンシズ,インコーポレーテッド 指向性マイクロ波化学のための方法および組成物
US20040209303A1 (en) * 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
EP1195606A1 (en) * 2000-10-03 2002-04-10 VBC-Genomics Forschungsges.m.b.H. Allergen-microarray assay
AU1189702A (en) 2000-10-13 2002-04-22 Fluidigm Corp Microfluidic device based sample injection system for analytical devices
AU2002239740A1 (en) * 2000-10-20 2002-06-11 Chad A. Mirkin Nanolithography methods and products therefor and produced thereby
US7820597B2 (en) 2000-10-24 2010-10-26 Fatemeh Mojtabai Ordered two-and three-dimensional structures of amphiphilic molecules
US20050100951A1 (en) * 2000-10-26 2005-05-12 Biocept, Inc. 3D format biochips and method of use
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7371562B2 (en) 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7875434B2 (en) * 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7575939B2 (en) * 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
DE10054055A1 (de) * 2000-10-31 2002-05-23 Nmi Univ Tuebingen Verfahren zur Analyse von Proteinen
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US20050084908A1 (en) * 2000-11-06 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Methods for detecting binding of low-molecular-weight compound and its binding partner molecule
US7123764B2 (en) 2000-11-08 2006-10-17 Surface Logix Inc. Image processing method for use in analyzing data of a chemotaxis or haptotaxis assay
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
EP1334361A2 (de) * 2000-11-17 2003-08-13 Zeptosens AG Kit und verfahren zur multianalytbestimmung, mit vorkehrungen zur referenzierung der dichte immobilisierter erkennungselemente
JP2002153272A (ja) * 2000-11-24 2002-05-28 Inst Of Physical & Chemical Res 生体分子マイクロアレイ
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
DE60141171D1 (de) 2000-11-27 2010-03-11 Intelligent Medical Devices Ll Klinische intelligente diagnostische vorrichtungen und verfahren
EP1360207B1 (en) * 2000-12-13 2011-06-22 Bac Ip B.V. Protein arrays of camelid heavy-chain immunoglobulin variable domains
FR2818287B1 (fr) * 2000-12-14 2003-01-17 Commissariat Energie Atomique Support solide pour l'immobilisation d'oligonucleotides
EP1344065A2 (en) 2000-12-14 2003-09-17 Paul Stroobant Differential phage capture proteomics
US6798521B2 (en) * 2000-12-29 2004-09-28 Texas Instruments Incorporated Robust integrated surface plasmon resonance sensor
WO2002056021A2 (en) * 2001-01-10 2002-07-18 Symyx Technologies Inc Polymer brushes for immobilizing molecules to a surface
CA2434699A1 (en) * 2001-01-17 2002-10-17 Randall W. Nelson An integrated high throughput system for the analysis of biomolecules
CA2434139C (en) * 2001-01-23 2014-05-27 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US20020169562A1 (en) * 2001-01-29 2002-11-14 Gregory Stephanopoulos Defining biological states and related genes, proteins and patterns
US7332286B2 (en) 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
EP1364201A4 (en) * 2001-02-06 2005-01-05 Univ Auburn LIGAND SENSOR DEVICES AND USES THEREOF
US6913697B2 (en) * 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
JP4797196B2 (ja) * 2001-02-14 2011-10-19 株式会社 フューエンス マイクロチップ
US20020165675A1 (en) * 2001-03-03 2002-11-07 Golovlev Valeri V. Method and microelectronic device for multi-site molecule detection
US20040191246A1 (en) 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
EP1366364A4 (en) * 2001-03-07 2006-05-17 Bio Rad Laboratories ASSAY SYSTEM FOR DETECTING AND MEASURING SIMULTANEOUSLY MULTIPLE MODIFIED CELLULAR PROTEINS
US20020137106A1 (en) * 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
CA2441086A1 (en) * 2001-03-19 2002-09-26 Wisconsin Alumni Research Foundation Identification of gene expression alterations underlying the aging process in mammals
WO2002074979A2 (en) * 2001-03-20 2002-09-26 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
AU2002253995A1 (en) * 2001-03-29 2002-10-15 Hybrigen, Inc. Improved hybrid gene libraries and uses thereof
US6960437B2 (en) 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US20040253634A1 (en) * 2001-04-10 2004-12-16 Denong Wang Novel microarrays and methods of use thereof
WO2002084252A2 (en) * 2001-04-17 2002-10-24 Xenoport, Inc. Epitope-captured antibody display
JP2004536290A (ja) * 2001-04-19 2004-12-02 ゲゼルシャフト フュア バイオテクノロギッシェ フォーシュンク エム ベー ハー(ゲー ベー エフ) 安定した、再生可能な抗体アレイの作製方法
US20030077616A1 (en) * 2001-04-19 2003-04-24 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
WO2002086081A2 (en) * 2001-04-20 2002-10-31 Carnegie Mellon University Methods and systems for identifying proteins
WO2002088388A1 (en) * 2001-04-26 2002-11-07 Ruebben Albert A method and a device for quantification of mutation loads
WO2002090923A2 (en) * 2001-05-03 2002-11-14 Sigma-Genosys, Ltd. Methods for assembling protein microarrays
EP1392342B1 (en) * 2001-05-11 2015-09-23 Yale University Global analysis of protein activities using proteome chips
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
US20080220441A1 (en) 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
WO2002096262A2 (en) * 2001-05-25 2002-12-05 Northwestern University Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2002345839A1 (en) * 2001-06-26 2003-03-03 Wisconsin Alumni Research Foundation Gene expression alterations underlying the retardation of aging by caloric restriction in mammals
US6844028B2 (en) * 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
WO2003003014A1 (en) * 2001-06-29 2003-01-09 Veri-Q, Inc. Methods and compositions for determining the purity of and purifying chemically synthesized nucleic acids
US20060019235A1 (en) * 2001-07-02 2006-01-26 The Board Of Trustees Of The Leland Stanford Junior University Molecular and functional profiling using a cellular microarray
AU2002365177A1 (en) * 2001-07-02 2003-07-24 The Board Of Trustees Of The Leland Stanford Junior University Microarrays for cell phenotyping and manipulation
CN100386627C (zh) * 2001-07-03 2008-05-07 包刚 过滤型蛋白芯片
US20060073610A1 (en) * 2001-07-06 2006-04-06 Millpore Corporation Patterned composite membrane and stenciling method for the manufacture thereof
US20030013208A1 (en) * 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
CA2563510A1 (en) * 2001-07-13 2005-11-17 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
AU2002322458A1 (en) * 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
IL159810A0 (en) * 2001-07-16 2004-06-20 Protein Forest Inc Matrixes, arrays, systems and methods
CA2652991A1 (en) * 2001-07-16 2003-11-13 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US6444318B1 (en) * 2001-07-17 2002-09-03 Surmodics, Inc. Self assembling monolayer compositions
US7172804B2 (en) * 2001-07-17 2007-02-06 Northwestern University Film-immobilized capture particles
US7517496B2 (en) * 2001-07-17 2009-04-14 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
AU2002367582A1 (en) * 2001-07-17 2003-09-29 Ciphergen Biosystems, Inc. Latex based adsorbent chip
US20030134273A1 (en) * 2001-07-17 2003-07-17 Eric Henderson Combined molecular binding detection through force microscopy and mass spectrometry
US20030143612A1 (en) * 2001-07-18 2003-07-31 Pointilliste, Inc. Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
US6977138B2 (en) 2001-07-24 2005-12-20 Massachusetts Institute Of Technology Reactive polymer coatings
EP1279963A1 (en) * 2001-07-27 2003-01-29 Université de Nantes Protein-target screening method using near-infrared fluorescent dyes
EP1281966A3 (en) * 2001-07-30 2003-06-18 Fuji Photo Film Co., Ltd. Method and apparatus for conducting a receptor-ligand reaction
WO2003011285A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. BENZIMIDAZO[4,5-f]ISOQUINOLINONE DERIVATIVES
US7172905B2 (en) * 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
US20100104631A1 (en) * 2001-08-13 2010-04-29 Lipella Pharmaceuticals Inc. Method of treatment for bladder dysfunction
US20030049626A1 (en) * 2001-08-14 2003-03-13 Milagen, Inc. Antibody-based analysis of matrix protein arrays
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
AU2002329864B2 (en) * 2001-08-27 2008-07-31 Surface Logix, Inc. Immobilization of biological molecules onto surfaces coated with monolayers
US6767731B2 (en) * 2001-08-27 2004-07-27 Intel Corporation Electron induced fluorescent method for nucleic acid sequencing
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
EP2184346B1 (en) 2001-09-06 2017-03-08 Rapid Micro Biosystems, Inc. Rapid detection of replicating cells
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
DE10145226A1 (de) * 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
DE10145700A1 (de) * 2001-09-17 2003-04-10 Infineon Technologies Ag Biochip-Anordnung, Sensor-Anordnung und Verfahren zum Betreiben einer Biochip-Anordnung
JP2003099614A (ja) * 2001-09-21 2003-04-04 Daiwa Securities Group Inc 保有口数内売却処理装置、保有口数内売却処理システム及びプログラム
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
JP4570363B2 (ja) * 2001-10-02 2010-10-27 ノースウエスタン ユニヴァーシティ タンパク質およびペプチドのナノアレイ
US20030073104A1 (en) * 2001-10-02 2003-04-17 Belcher Angela M. Nanoscaling ordering of hybrid materials using genetically engineered mesoscale virus
US7192629B2 (en) * 2001-10-11 2007-03-20 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
JP4377689B2 (ja) 2001-10-15 2009-12-02 バイオアレイ ソリューションズ リミテッド 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析
AU2002367935A1 (en) * 2001-10-23 2003-12-22 Sloan Kettering Institute For Cancer Research Protein micro-arrays and multi-layered affinity interaction detection
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
CA2466656C (en) 2001-11-09 2013-07-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
US20050095646A1 (en) * 2001-11-19 2005-05-05 Sherman Michael I. Method of using a non-antibody protein to detect and measure an analyte
EP1527341B1 (en) * 2001-11-20 2009-06-17 Duke University Interfacial biomaterials
AU2002365404A1 (en) * 2001-11-27 2003-06-10 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
US6797393B2 (en) 2001-11-30 2004-09-28 Eastman Kodak Company Method for making biochip substrate
US7361310B1 (en) 2001-11-30 2008-04-22 Northwestern University Direct write nanolithographic deposition of nucleic acids from nanoscopic tips
US7118910B2 (en) 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
ES2289169T3 (es) 2001-12-05 2008-02-01 Sense Proteomic Limited Redes de proteinas para variantes alelicas y sus usos.
US20050112616A1 (en) * 2001-12-10 2005-05-26 William Lee Functionalized materials and libraries thereof
EP1319954A1 (en) * 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
JP4382339B2 (ja) * 2001-12-14 2009-12-09 富士フイルム株式会社 測定チップ
GB0130318D0 (en) * 2001-12-19 2002-02-06 Univ Leeds Membrane
JP2005513503A (ja) * 2001-12-21 2005-05-12 ビアコーレ・アー・ベー 結合物質の固定化
KR20030057219A (ko) * 2001-12-28 2003-07-04 삼성에스디아이 주식회사 기질에 중간층을 형성시키는 화합물, 이를 포함하는중간층 형성용 조성물 및 이를 이용한 바이오칩
KR100450202B1 (ko) * 2002-01-07 2004-09-24 삼성에스디아이 주식회사 생체물질 고정용 관능기의 패턴 형성 방법
WO2003062789A2 (en) * 2002-01-16 2003-07-31 Panomics, Inc. Methods for isolating and characterizing short-lived proteins and arrays derived therefrom
US7056665B2 (en) 2002-01-16 2006-06-06 Panomics, Inc. Screening methods involving the detection of short-lived proteins
US20060228723A1 (en) * 2002-01-16 2006-10-12 Keith Bradley System and method for electronic sensing of biomolecules
US20030134433A1 (en) * 2002-01-16 2003-07-17 Nanomix, Inc. Electronic sensing of chemical and biological agents using functionalized nanostructures
US20070178477A1 (en) * 2002-01-16 2007-08-02 Nanomix, Inc. Nanotube sensor devices for DNA detection
US20040048311A1 (en) * 2002-01-24 2004-03-11 Dana Ault-Riche Use of collections of binding sites for sample profiling and other applications
JP2003222589A (ja) * 2002-01-31 2003-08-08 Communication Research Laboratory 二波長表面プラズモン共鳴分光装置
SE0200269D0 (sv) * 2002-01-31 2002-01-31 Ellem Bioteknik Ab Material for implantation
AU2003217306A1 (en) * 2002-02-07 2003-09-02 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Diagnostic microarray and method of use thereof
JP4284412B2 (ja) * 2002-03-01 2009-06-24 独立行政法人産業技術総合研究所 細胞およびリポソームの固定化体とその固定化方法
US20050266455A1 (en) * 2002-03-02 2005-12-01 Sci Tec, Inc. Method and microelectronic device for multi-site molecule detection
US6815078B2 (en) 2002-03-06 2004-11-09 Eastman Kodak Company Substrate for protein microarray containing functionalized polymer
WO2003074722A2 (en) * 2002-03-07 2003-09-12 Zephyr Proteomix Ltd. Microarrays of cellulose binding chimeric proteins and methods of use thereof
DE60325847D1 (de) * 2002-03-11 2009-03-05 Caprotec Bioanalytics Gmbh Verbindungen und verfahren für die analyse des proteoms
US6703216B2 (en) 2002-03-14 2004-03-09 The Regents Of The University Of California Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB)
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
EP1499706A4 (en) 2002-04-01 2010-11-03 Fluidigm Corp MICROFLUIDIC PARTICLE ANALYSIS SYSTEMS
US20030215858A1 (en) * 2002-04-08 2003-11-20 Baylor College Of Medicine Enhanced gene expression system
US20040033546A1 (en) * 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
US20030194709A1 (en) * 2002-04-10 2003-10-16 Xing Yang Hydrophobic zone device
US7687256B2 (en) * 2002-04-11 2010-03-30 Spire Corporation Surface activated biochip
AU2003267951A1 (en) * 2002-04-26 2003-12-19 Genencor International, Inc. Methods and articles for high throughput analysis of biomolecular interactions
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US7102005B2 (en) * 2002-05-03 2006-09-05 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US20030211478A1 (en) * 2002-05-08 2003-11-13 Gentel Corporation Transcription factor profiling on a solid surface
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
US7460960B2 (en) * 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
CA2485560A1 (en) * 2002-05-10 2004-06-03 Engeneos, Inc. Unique recognition sequences and methods of use thereof in protein analysis
EP1534755B1 (en) * 2002-05-10 2011-10-12 Bio-Layer Pty Limited Generation of surface coating diversity
US20060014212A1 (en) * 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
AU2003204160B2 (en) * 2002-05-13 2010-05-13 Corning Incorporated Self-aliquoting sample storage plate system
US8785179B2 (en) * 2002-05-22 2014-07-22 Texas Instruments Incorporated Biosensor and method
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
EP1534306A2 (en) * 2002-05-31 2005-06-01 Ciphergen Biosystems, Inc. Defensins: use as antiviral agents
EP1369692A3 (en) * 2002-06-04 2003-12-17 Interuniversitaire Microelectronica Centrum vzw ( IMEC) Sensor surface
EP1413886A1 (en) * 2002-10-25 2004-04-28 Interuniversitair Microelektronica Centrum ( Imec) Sensor surface
US7135343B2 (en) * 2002-06-17 2006-11-14 Agilent Technologies, Inc. Biomolecule resistant and their methods of use in assays
EP1552297A4 (en) * 2002-06-20 2006-08-09 Paul Stroobant IMPROVED METHODS APPLIED TO PROTEOMICS BY DIFFERENTIAL CAPTURE
US7948041B2 (en) 2005-05-19 2011-05-24 Nanomix, Inc. Sensor having a thin-film inhibition layer
DE60325743D1 (de) * 2002-07-02 2009-02-26 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
USH2223H1 (en) * 2002-07-11 2008-09-02 The United States Of America As Represented By The Secretary Of The Navy Patterned, micrometer-sized antibody features
US20040009528A1 (en) * 2002-07-11 2004-01-15 Shyh-Yu Shaw Protein chips
US20050008828A1 (en) * 2002-07-25 2005-01-13 Trustees Of Stevens Institute Of Technology Patterned polymer microgel and method of forming same
JP4099822B2 (ja) * 2002-07-26 2008-06-11 セイコーエプソン株式会社 ディスペンシング装置、ディスペンシング方法及び生体試料含有溶液吐出不良検出方法
EP2218495A1 (en) * 2002-07-29 2010-08-18 MT Technologies, Inc. Biomimetic membranes
US20040067597A1 (en) * 2002-07-31 2004-04-08 Caliper Technologies Corp. High density reagent array preparation methods
US20050074898A1 (en) * 2002-07-31 2005-04-07 Caliper Technologies Corp. High density reagent array preparation methods
CN1672050A (zh) * 2002-08-02 2005-09-21 美国艾培拉公司 荧光偏振检测
WO2004013290A2 (en) * 2002-08-05 2004-02-12 Invitrogen Corporation Compositions and methods for molecular biology
AU2003255253A1 (en) * 2002-08-13 2004-02-25 Discovery Partners International Spotting pattern for placement of compounds in an array
GB2391867A (en) * 2002-08-13 2004-02-18 Smartbead Technologies Ltd Analysis system using coded supports
US20040063124A1 (en) * 2002-08-15 2004-04-01 Proteoplex, Inc. Methods and apparatus for preparing and assaying biological samples to determine protein concentration
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
AU2003269968A1 (en) * 2002-08-16 2004-03-11 Clinical Microarrays, Inc. Substrates for isolating, reacting and microscopically analyzing materials
JP2005535898A (ja) * 2002-08-16 2005-11-24 ザイオミックス インコーポレーテッド 表面官能化のための方法及び試薬
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
WO2004020065A2 (en) * 2002-08-28 2004-03-11 Mt Technologies, Inc. Microfluidic affinity system using polydimethylsiloxane and a surface modification process
EP1540677A2 (en) * 2002-08-29 2005-06-15 Bioscale Inc. Resonant sensor and sensing system
AU2003258683A1 (en) * 2002-09-03 2004-03-29 Zeptosens Ag Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
ATE520027T1 (de) * 2002-09-03 2011-08-15 Bayer Technology Services Gmbh Analytische plattform und nachweisverfahren mit gegebenenfalls nach fraktionierung in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
EP1548437A4 (en) * 2002-09-17 2006-06-07 Olympus Corp METHOD FOR ARRANGING FLUID REACTION COMPONENTS ON A SUBSTRATE SURFACE TO DETECT A TARGET SUBSTANCE THROUGH RESPONSE OF SEVERAL COMPONENTS ON THE SUBSTRATE, DEVICE D R AND ARTICLES FOR USE IN THE PROCESS
US20050064508A1 (en) * 2003-09-22 2005-03-24 Semzyme Peptide mediated synthesis of metallic and magnetic materials
JP2004105070A (ja) * 2002-09-18 2004-04-08 Inst Of Physical & Chemical Res 無細胞タンパク質合成系を用いたリガンド結合タンパク質の製造方法及びその使用
WO2004027379A2 (en) * 2002-09-20 2004-04-01 Novus Molecular, Inc. Methods and devices for active bioassay
CA2500283A1 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
AU2003299541A1 (en) 2002-10-02 2004-05-25 California Institute Of Technology Microfluidic nucleic acid analysis
WO2004035169A2 (en) * 2002-10-15 2004-04-29 The Regents Of The University Of Michigan Multidimensional protein separation system
CN1726394B (zh) * 2002-10-15 2010-10-13 阿伯麦特里科斯公司 针对短表位的数字化抗体组以及其使用方法
DE10249608A1 (de) * 2002-10-18 2004-05-06 Gkss-Forschungszentrum Geesthacht Gmbh Vorrichtung und Verfahren zur Strukturanalyse und Detektion von komplexen Glykostrukturen
EP1576374B1 (en) * 2002-10-25 2008-08-06 Sense Proteomic Limited Enzyme array and assay
US20040081969A1 (en) * 2002-10-29 2004-04-29 Ilsley Diane D. Devices and methods for evaulating the quality of a sample for use in an array assay
CA2504443A1 (en) * 2002-10-30 2004-05-13 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
CA2545304A1 (en) * 2002-11-08 2004-05-21 University Of Copenhagen Method of immobilising a protein to a zeolite
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20040096914A1 (en) * 2002-11-20 2004-05-20 Ye Fang Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof
AU2003300859A1 (en) * 2002-12-11 2004-06-30 New England Biolabs, Inc. Carrier-ligand fusions and uses thereof
US20040209353A1 (en) * 2002-12-12 2004-10-21 Chiron Corporation Biological sample storage device and method for biological sample contamination testing
CA2508359A1 (en) * 2002-12-12 2004-06-24 Nanosphere, Inc. Direct snp detection with unamplified dna
EP1739185A1 (en) 2002-12-18 2007-01-03 Ciphergen Biosystems, Inc. Serum biomarkers in lung cancer
US20040121339A1 (en) * 2002-12-19 2004-06-24 Jizhong Zhou Special film-coated substrate for bio-microarray fabrication and use thereof
CA2508939A1 (en) * 2002-12-22 2004-07-15 The Scripps Research Institute Protein arrays
US7695723B2 (en) 2002-12-31 2010-04-13 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
US7785601B2 (en) 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
CA2512181A1 (en) * 2003-01-02 2004-07-22 Bioforce Nanosciences, Inc. Method and apparatus for molecular analysis in small sample volumes
KR100523212B1 (ko) * 2003-01-04 2005-10-24 한국과학기술원 반응 단백질과 그의 기질 펩타이드간의 반응분석을 위한단백질 칩
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
WO2004063371A1 (ja) * 2003-01-10 2004-07-29 Protein Crystal Co., Ltd. タンパク質複合体及びその製造方法並びにその用途
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
US20040137158A1 (en) * 2003-01-15 2004-07-15 Kools Jacques Constant Stefan Method for preparing a noble metal surface
US20060051879A9 (en) * 2003-01-16 2006-03-09 Hubert Koster Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
KR100994566B1 (ko) * 2003-01-20 2010-11-15 삼성전자주식회사 고정화 영역을 갖는 포토레지스트 막을 포함하는 어레이장치 및 이를 이용한 표적 물질 검출방법
WO2004071641A2 (en) * 2003-02-10 2004-08-26 Pointilliste, Inc. Self-assembling arrays and uses thereof
US20050008851A1 (en) * 2003-02-18 2005-01-13 Fuji Photo Film Co., Ltd. Biosensor
US20070287015A1 (en) * 2003-02-25 2007-12-13 Yeda Research And Development Co. Ltd. Nanoscopic Structure and Devices Using the Same
US20050130174A1 (en) * 2003-02-27 2005-06-16 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
CN1514243A (zh) * 2003-04-30 2004-07-21 成都夸常科技有限公司 对目标物进行定性和/或定量分析的方法、装置和标记物及检测试剂盒
EP1606419A1 (en) 2003-03-18 2005-12-21 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
US20040185445A1 (en) * 2003-03-19 2004-09-23 Ye Fang Universal readout for target identification using biological microarrays
US8068990B2 (en) * 2003-03-25 2011-11-29 Hologic, Inc. Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids
US7191068B2 (en) * 2003-03-25 2007-03-13 Proteogenix, Inc. Proteomic analysis of biological fluids
WO2004087323A1 (en) * 2003-03-28 2004-10-14 Mergen Ltd. Multi-array systems and methods of use thereof
US20040197841A1 (en) * 2003-04-02 2004-10-07 Apffel James Alexander Methods and reagents for multiplexed analyses
EP1615721B1 (en) 2003-04-03 2014-06-18 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US20040248205A1 (en) * 2003-04-16 2004-12-09 Stern Lawrence J. Major histocompatibility complex (MHC)-peptide arrays
US7341838B2 (en) 2003-04-17 2008-03-11 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20060205010A1 (en) * 2003-04-22 2006-09-14 Catherine Allioux Methods of host cell protein analysis
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
KR100547015B1 (ko) * 2003-05-23 2006-01-26 주식회사 올메디쿠스 일정한 크기 이상의 분석물질을 정량 분석하기 위한바이오센서 및 그 제조방법
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
WO2004111203A1 (ja) * 2003-06-10 2004-12-23 Shimadzu Corporation 哺乳動物培養細胞抽出液およびその調製方法、ならびに該抽出液を用いた無細胞系タンパク質合成方法
WO2004113872A2 (en) * 2003-06-24 2004-12-29 The Trustees Of Columbia University In The City Of New York Covalent methods for immobilization of thiolated biomolecules on siliceous and metallic surfaces
US20040265921A1 (en) * 2003-06-30 2004-12-30 National University Of Singapore Intein-mediated attachment of ligands to proteins for immobilization onto a support
US7794947B2 (en) * 2003-07-10 2010-09-14 Institute For Systems Biology Affinity capture of peptides by microarray and related methods
US9243275B1 (en) * 2003-07-10 2016-01-26 Polytechnic Institute Of New York University Biosensor and method of making same
EP1660858A4 (en) * 2003-07-21 2007-10-24 Amplified Proteomics Inc MULTIPLEX analyte
US20060014003A1 (en) * 2003-07-24 2006-01-19 Libera Matthew R Functional nano-scale gels
EP2295569A1 (en) 2003-07-25 2011-03-16 Ambion, Inc. Methods and compositions for preparing rna from a fixed sample
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
US7745023B2 (en) * 2003-08-08 2010-06-29 Regents Of The University Of Minnesota Structured material for the production of hydrogen
CA2534661A1 (en) 2003-08-08 2005-02-17 Genenews Inc. Osteoarthritis biomarkers and uses thereof
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7223609B2 (en) * 2003-08-14 2007-05-29 Agilent Technologies, Inc. Arrays for multiplexed surface plasmon resonance detection of biological molecules
AU2004267802B2 (en) * 2003-08-18 2011-03-17 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
JP4754352B2 (ja) * 2003-08-29 2011-08-24 株式会社リバース・プロテオミクス研究所 タンパク質の固定化方法
WO2005024378A2 (en) 2003-09-03 2005-03-17 Zyomix, Inc. Ion detection using a pillar chip
US20050176026A1 (en) * 2003-09-05 2005-08-11 Franck Carl P. Liquid mixing reactor for biochemical assays
US20050053949A1 (en) * 2003-09-08 2005-03-10 Silin Vitalii Ivanovich Biochip for proteomics applications
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
KR100518953B1 (ko) * 2003-09-19 2005-10-12 주식회사 제노포커스 포자 외막단백질을 이용한 목적단백질의 표면발현 방법
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US8298780B2 (en) * 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
EP1664722B1 (en) 2003-09-22 2011-11-02 Bioarray Solutions Ltd Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US20050069949A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfabricated Fluidic Structures
US20050069462A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfluidics Packaging
US20070017870A1 (en) 2003-09-30 2007-01-25 Belov Yuri P Multicapillary device for sample preparation
EP1677886A1 (en) * 2003-09-30 2006-07-12 Chromba, Inc. Multicapillary column for chromatography and sample preparation
US20050079507A1 (en) * 2003-10-09 2005-04-14 Ye Fang Target evaluation using biological membrane arrays
WO2005047851A2 (en) * 2003-10-15 2005-05-26 The Trustees Of Columbia University In The City Of New York Device for measuring nanometer level pattern-dependent binding reactions
US20050084981A1 (en) * 2003-10-16 2005-04-21 Magdalena Ostrowski Method of depositing a bioactive material on a substrate
US20050112650A1 (en) * 2003-10-20 2005-05-26 Ciphergen Biosystems, Inc. Reactive polyurethane-based polymers
WO2005040800A1 (es) * 2003-10-23 2005-05-06 Consejo Superior De Investigaciones Científicas Procedimiento de fabricación y uso de un nuevo array de proteínas, dicho array de proteínas y sus aplicaciones
JP2006514299A (ja) * 2003-10-27 2006-04-27 センス プロテオミック リミテッド 酵素アレイ及びアッセイ
WO2005042763A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US7049077B2 (en) 2003-10-29 2006-05-23 Bioarray Solutions Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
AU2004290375A1 (en) * 2003-11-06 2005-05-26 Sru Biosystems, Inc. High-density amine-functionalized surface
EP1694816B1 (en) 2003-11-07 2013-08-28 Ciphergen Biosystems, Inc. Biomarkers for alzheimer's disease
US20060007515A1 (en) * 2003-11-13 2006-01-12 Dmitri Simonian Surface lubrication in microstructures
US7153896B2 (en) 2003-11-14 2006-12-26 Eastman Kodak Company Element for protein microarrays
US7332355B2 (en) * 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
CA2545653C (en) 2003-11-21 2014-07-08 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
KR100580631B1 (ko) * 2003-11-22 2006-05-16 삼성전자주식회사 산화막을 갖는 기판, 그를 이용한 표적 물질 검출 방법 및광학적 센서
US20090246889A1 (en) * 2003-11-22 2009-10-01 Samsung Electronics Co., Ltd. Substrate having oxide layer, method for detecting target material using the substrate, and optical sensor including the substrate
US20050109622A1 (en) * 2003-11-26 2005-05-26 Peter Peumans Method for controlling electrodeposition of an entity and devices incorporating the immobilized entity
WO2005055812A2 (en) 2003-12-05 2005-06-23 Ciphergen Biosystems, Inc. Serum biomarkers for chagas disease
AU2004296412B2 (en) * 2003-12-12 2011-03-10 Anteo Technologies Pty Ltd A method for designing surfaces
WO2005059552A1 (en) 2003-12-15 2005-06-30 University Of Pennsylvania Method and devices for running reactions on a target plate for maldi mass spectrometry
US20050170445A1 (en) * 2004-01-07 2005-08-04 Duke University Methods of establishing profiles for use in evaluating wound healing and biocompatibility of implant materials and microarrays useful therefor
US20060018911A1 (en) * 2004-01-12 2006-01-26 Dana Ault-Riche Design of therapeutics and therapeutics
JP2005204609A (ja) * 2004-01-26 2005-08-04 Canon Inc 有機物固定化用キット、有機物固定化構造体及びその製造方法
US20050208597A1 (en) * 2004-01-26 2005-09-22 The Board Of Trustees Of The Leland Stanford Junior University Microarray analysis of post-translational modifications
EP1562046A1 (de) * 2004-02-03 2005-08-10 B.R.A.H.M.S Aktiengesellschaft Diagnose von Sepsis durch selektive Bestimmung der Konzentration der Cu/Zn Superoxiddismutase (Cu/Zn SOD) in Patientenproben
MXPA06009452A (es) 2004-02-19 2007-03-15 Univ Alberta Polimorfismos del promotor de leptin y sus usos.
JP2005269902A (ja) * 2004-03-22 2005-10-06 Seiko Epson Corp 固相表面に細胞を固定化する方法
US7723126B2 (en) * 2004-03-24 2010-05-25 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of inorganic oxide surfaces
US7276283B2 (en) * 2004-03-24 2007-10-02 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of carbon-containing substrates
CN100357738C (zh) * 2004-03-26 2007-12-26 博奥生物有限公司 一种检测小分子化合物的方法
JP2005312425A (ja) * 2004-03-31 2005-11-10 Toyo Kohan Co Ltd ポリペプチドを固定化する方法、ポリペプチドが固定化されてなる固体支持体、これを用いたポリペプチドの検出方法及び精製方法、ならびにポリペプチドを固定化するための固体支持体
US7371331B2 (en) * 2004-04-01 2008-05-13 Valerie J Marty Method of creating a patterned monolayer on a surface
JP4451193B2 (ja) * 2004-04-12 2010-04-14 大日本印刷株式会社 パターン形成体の製造方法
WO2005108615A2 (en) * 2004-04-14 2005-11-17 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
AU2005238446B2 (en) 2004-04-15 2009-07-30 Banyan Biomarkers Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
JP2007535324A (ja) 2004-04-26 2007-12-06 チルドレンズ メディカル センター コーポレーション 疾患検出のための血小板バイオマーカー
EP1742054A4 (en) * 2004-04-28 2008-01-16 Japan Science & Tech Agency METHOD FOR PRODUCING BIOPUCE; BIOCHIP; BIOPUCE ANALYSIS DEVICE; BIOPUCE ANALYSIS METHOD
EP2527447A1 (en) 2004-06-03 2012-11-28 Athlomics Pty Ltd Agents and methods for diagnosing stress
US20060251795A1 (en) * 2005-05-05 2006-11-09 Boris Kobrin Controlled vapor deposition of biocompatible coatings for medical devices
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
EP1773866B1 (en) 2004-07-02 2013-06-19 Bio-Layer Pty Limited Use of metal complexes
US20060009623A1 (en) * 2004-07-06 2006-01-12 National University Of Singapore C-terminal attachment of ligands to proteins for immobilization onto a support
US20060014155A1 (en) * 2004-07-16 2006-01-19 Wisconsin Alumni Research Foundation Methods for the production of sensor arrays using electrically addressable electrodes
WO2006007664A1 (en) * 2004-07-22 2006-01-26 Genomics Research Partners Pty Ltd Agents and methods for diagnosing osteoarthritis
US20090035784A1 (en) * 2004-07-30 2009-02-05 Mount Sinai School Of Medicine Of New York University Npc1l1 and npc1l1 inhibitors and methods of use thereof
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
JP2008508531A (ja) * 2004-08-04 2008-03-21 アクセラ バイオセンサーズ インク. 回折に基づく検出のための化学架橋剤でパターン化された表面
US20060040377A1 (en) * 2004-08-17 2006-02-23 Biocept, Inc. Protein microarrays
US20130040840A1 (en) * 2004-09-02 2013-02-14 Bioarray Solutions, Ltd. Nucleic acid amplification with integrated multiplex detection
US20060052948A1 (en) * 2004-09-09 2006-03-09 Jorn Gorlach Method of identifying drugs, targeting moieties or diagnostics
US20060051348A1 (en) 2004-09-09 2006-03-09 Jorn Gorlach Method of producing a plurality of isolated antibodies to a plurality of cognate antigens
CN101437959A (zh) * 2004-09-20 2009-05-20 普罗特奥格尼克斯公司 诊断胎儿非整倍体
ITVR20040149A1 (it) * 2004-09-22 2004-12-22 Sanitaria Scaligera Spa Sistema di monitoraggio rapido del gruppo sanguigno e per la rivelazione di reazioni immunoematologiche
US7592139B2 (en) * 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
JP2006095452A (ja) * 2004-09-30 2006-04-13 Fuji Photo Film Co Ltd スピンコート製膜法
WO2006041392A1 (en) * 2004-10-13 2006-04-20 Biacore Ab Preparation and use of a reactive solid support surface
SE0402476D0 (sv) * 2004-10-13 2004-10-13 Biacore Ab Preparation and use of a reactive solid support surface
WO2006047417A2 (en) 2004-10-21 2006-05-04 University Of Florida Research Foundation, Inc. Detection of cannabinoid receptor biomarkers and uses thereof
US20110077164A1 (en) * 2004-10-23 2011-03-31 Andras Guttman Expression profiling platform technology
EP1802981B8 (en) * 2004-10-23 2012-09-12 BioSystems International SAS Expression profiling platform technology
WO2006049498A1 (en) * 2004-11-05 2006-05-11 Modiquest B.V. Means and methods for isolating and/or identifying a target molecule
US20060246467A1 (en) * 2004-11-15 2006-11-02 California Institute Of Technology Biomarker sensors and method for multi-color imaging and processing of single-molecule life signatures
US20060223195A1 (en) * 2004-11-16 2006-10-05 Meyer Grant D Stress based removal of nonspecific binding from surfaces
US7745143B2 (en) * 2004-11-19 2010-06-29 Plexera, Llc Plasmon resonance biosensor and method
DE502005003509D1 (de) * 2004-11-19 2008-05-08 Ebm Papst St Georgen Gmbh & Co Anordnung mit einem luefter und einer pumpe
US20070172904A1 (en) * 2004-11-24 2007-07-26 Dementieva Ekaterina I Method for quantitative detection of biological toxins
WO2006056490A1 (en) * 2004-11-29 2006-06-01 Centre National De La Recherche Scientifique Trichloro silyl alkyl isocyanate molecule and surface modified mineral substrate
CA2590188A1 (en) * 2004-12-08 2006-06-15 Lyotropic Therapeutics, Inc. Compositions for binding to assay substrata and methods of using
US20080003599A1 (en) * 2004-12-28 2008-01-03 Dary Ekaterina L Biological Microchip for Multiple Parallel Immunoassay of Compounds and Immunoassay Metods Using Said Microchip
ATE501267T1 (de) * 2005-01-06 2011-03-15 Eastern Virginia Med School Apolipoprotein-a-ii-isoform als biomarker für prostatakrebs
JP4736439B2 (ja) * 2005-01-25 2011-07-27 東レ株式会社 核酸固定化担体
AU2006207954A1 (en) 2005-01-28 2006-08-03 Childrens Medical Center Corporation Methods for diagnosis and prognosis of epithelial cancers
US7396689B2 (en) * 2005-02-04 2008-07-08 Decision Biomarkers Incorporated Method of adjusting the working range of a multi-analyte assay
US7713695B2 (en) 2005-02-07 2010-05-11 Genenews, Inc. Mild osteoarthritis biomarkers and uses thereof
JP2006335912A (ja) * 2005-06-03 2006-12-14 Fujifilm Holdings Corp 生理活性物質固定化剤
DE602006009980D1 (de) * 2005-02-23 2009-12-10 Fujifilm Corp Biosensor
US20060234265A1 (en) * 2005-03-21 2006-10-19 Jim Richey Microarrays having multi-functional, compartmentalized analysis areas and methods of use
JP4435709B2 (ja) * 2005-03-22 2010-03-24 富士フイルム株式会社 バイオセンサー
US20060257902A1 (en) * 2005-03-25 2006-11-16 Ambion, Inc. Methods and compositions for depleting abundant RNA transcripts
US8048638B2 (en) 2005-04-01 2011-11-01 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
WO2006107846A2 (en) 2005-04-01 2006-10-12 University Of Florida Research Foundation, Inc. Biomakers of liver injury
US20060234269A1 (en) * 2005-04-18 2006-10-19 Matthew Asplund Laser Modification and Functionalization of Substrates
DK1877773T3 (en) * 2005-04-26 2015-01-19 Bayer Ip Gmbh NEW APPARATUS AND PROCEDURE FOR THE COATING OF CARRIER SUBSTRATES FOR ANALYTICAL DETECTION BY THE AFFINITY DETECTION PROCEDURE
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US8563329B2 (en) 2005-05-02 2013-10-22 Anp Technologies, Inc. Polymer conjugate enhanced bioassays
WO2006124644A2 (en) * 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
DK1907000T4 (da) 2005-06-08 2020-03-30 The President And Fellows Of Harvard College Fremgangsmåder og sammensætninger til behandling af persisterende HIV-infektioner ved hæmning af reaktionsvejen for programmeret celledød 1 (PD-1).
EP1910826A4 (en) * 2005-06-15 2010-01-20 Univ Arizona State Microstructure and microdomain microarrays, methods of making and using thereof
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
EP2993474B1 (en) 2005-06-24 2019-06-12 Vermillion, Inc. Biomarkers for ovarian cancer: beta-2 microglobulin
CN101501215A (zh) 2005-07-07 2009-08-05 阿什洛米克斯控股有限公司 用于诊断内毒素血症的多核苷酸标记基因及它们的表达
US9150850B2 (en) 2005-08-22 2015-10-06 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US7464580B2 (en) * 2005-09-26 2008-12-16 Oakland University Ionic liquid high temperature gas sensors
FR2891279B1 (fr) * 2005-09-27 2007-12-14 Centre Nat Rech Scient Nouvelles puces pour la detection par le plasmon de surface (spr)
WO2007047408A2 (en) * 2005-10-12 2007-04-26 Pathologica, Llc. Promac signature application
US20070141627A1 (en) * 2005-10-19 2007-06-21 Behrens Timothy W Systemic Lupus Erythematosus
CN101370946B (zh) 2005-10-21 2011-07-20 基因信息股份有限公司 用于使生物标志产物水平与疾病相关联的方法和装置
US7955837B2 (en) 2005-10-29 2011-06-07 Bayer Technology Services Gmbh Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
FR2893130B1 (fr) * 2005-11-08 2008-05-02 Thales Sa Dispositif d'imagerie pour biopuce, et biopuce associee
EP1951710A4 (en) 2005-11-09 2010-08-25 Univ Columbia PHOTOCHEMICAL PROCESSES AND PHOTOACTIVE COMPOSITIONS FOR MODIFYING SURFACES
EP1953550A4 (en) * 2005-11-10 2010-04-14 Nat University Of Corp Hiroshi METHOD AND MEANS FOR IMMOBILIZING PROTEIN FROM A PROTEIN BONDED TO A SILICON OXYGEN-SUBSTANCE
ES2356080T3 (es) * 2005-11-10 2011-04-04 Bristol-Myers Squibb Pharma Company Moesina, caveolina y proteina 1 asociada a yes como marcadores de respuesta a dasatinib en canceres de mama.
US8372596B2 (en) * 2005-11-10 2013-02-12 National University Of Corporation Hiroshima University Asbestos detection method, asbestos detection agent, asbestos detection kit, method for screening candidate for agent aiming at preventing or treating disease for which asbestos is causative or worsening factor
WO2007061981A2 (en) * 2005-11-21 2007-05-31 Lumera Corporation Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
WO2007070809A2 (en) * 2005-12-12 2007-06-21 Mcgill University Biomarkers for babesia
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US8334257B2 (en) 2005-12-20 2012-12-18 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
JP2007171003A (ja) * 2005-12-22 2007-07-05 Fujifilm Corp 質量分析用基板並びに分析方法および装置
US7781203B2 (en) * 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
WO2007076580A1 (en) * 2005-12-30 2007-07-12 Bio-Layer Pty Limited Binding of molecules
WO2008013569A2 (en) * 2006-01-03 2008-01-31 The President And Fellows Of Harvard College Small molecule printing
US7709227B2 (en) * 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
US7648834B2 (en) * 2006-01-17 2010-01-19 Moore Wayne E Plasmon fluorescence augmentation for chemical and biological testing apparatus
US20090011428A1 (en) * 2006-01-18 2009-01-08 The Regents Of The University Of California Fluid Membrane-Based Ligand Display System for Live Cell Assays and Disease Diagnosis Applications
AU2007209980A1 (en) * 2006-01-27 2007-08-09 Eastern Virginia Medical School Proteomic fingerprinting of human IVF-derived embryos: identification of biomarkers of developmental potential
JP4833679B2 (ja) * 2006-01-31 2011-12-07 富士通株式会社 密度が調整された分子膜の製造方法及び製造装置
US8008067B2 (en) * 2006-02-13 2011-08-30 University Of Maryland, Baltimore County Microwave trigger metal-enhanced chemiluminescence (MT MEC) and spatial and temporal control of same
US20070196876A1 (en) 2006-02-17 2007-08-23 Moses Marsha A Free NGAL as a biomarker for cancer
US20070207504A1 (en) * 2006-03-06 2007-09-06 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Proteomic methods for the identification of differentiated adipose cells and adipose derived adult stem cells
US8097425B2 (en) * 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
JP5357746B2 (ja) 2006-03-11 2013-12-04 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 末梢性の動脈疾患のためのバイオマーカーとしてのβ−2ミクログロブリン
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US7909928B2 (en) 2006-03-24 2011-03-22 The Regents Of The University Of Michigan Reactive coatings for regioselective surface modification
WO2008033167A2 (en) 2006-03-28 2008-03-20 Inanovate, Inc. Nano-particle biochip substrates
US7886577B2 (en) 2006-03-30 2011-02-15 Oakland University Devices with surface bound ionic liquids and method of use thereof
US8375768B2 (en) * 2006-03-30 2013-02-19 Oakland University Ionic liquid thin layer sensor for electrochemical and/or piezoelectric measurements
WO2007115207A2 (en) * 2006-03-31 2007-10-11 Regents Of The University Of Minnesota Irf-5 haplotypes in systemic lupus erythematosus
US20080003694A1 (en) * 2006-04-18 2008-01-03 Swanson Basil I Robust, self-assembled, biocompatible films
US7923054B2 (en) 2006-04-19 2011-04-12 Gore Enterprise Holdings, Inc. Functional porous substrates for attaching biomolecules
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
EP2035541A4 (en) * 2006-05-31 2010-11-24 Univ Johns Hopkins LASER ABLATION MACHINING OF BIOMOLECULAR PATTERNS ON SUBSTRATES
US7947148B2 (en) 2006-06-01 2011-05-24 The Regents Of The University Of Michigan Dry adhesion bonding
KR100931027B1 (ko) 2006-06-27 2009-12-10 한국생명공학연구원 N-말단에 시스테인 태그된 단백질 g 변형체
US20090297401A1 (en) * 2006-06-28 2009-12-03 Rgb Technologies Ab Sensor kit and a system for detecting an analyte in a test environment
US8178316B2 (en) * 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
FR2903590B1 (fr) * 2006-07-13 2013-05-10 Commissariat Energie Atomique Dispositif de prelevement cellulaire par contact
US20100003189A1 (en) 2006-07-14 2010-01-07 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
WO2008008523A1 (en) * 2006-07-14 2008-01-17 Regents Of The University Of Minnesota COMPOUNDS THAT BIND α5β1 INTEGRIN AND METHODS OF USE
KR100813262B1 (ko) * 2006-07-25 2008-03-13 삼성전자주식회사 광 촉매를 이용한 패터닝된 스팟 마이크로어레이의 제조방법 및 상기 방법에 의해 제조된 마이크로어레이
US20090269858A1 (en) * 2006-08-02 2009-10-29 Koninklijke Philips Electronics N.V. Method of determining the concentration of an analyte using analyte sensor molecules coupled to a porous membrane
GB0617429D0 (en) 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
DK2089722T3 (en) 2006-09-07 2018-01-22 Otago Innovation Ltd BIOMARKET FOR EARLY DETECTION OF ACUTE HEART DISORDERS
US8658573B2 (en) * 2006-09-11 2014-02-25 The Trustees Of Columbia University In The City Of New York Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies
US8273539B2 (en) 2006-09-25 2012-09-25 Mayo Foundation For Medical Education And Research Extracellular and membrane-associated prostate cancer markers
US20090087925A1 (en) * 2007-10-01 2009-04-02 Zyomyx, Inc. Devices and methods for analysis of samples with depletion of analyte content
US20080085512A1 (en) * 2006-10-05 2008-04-10 D Andrade Petula N Array assay devices and methods for making and using the same
EP2511844B1 (en) * 2006-10-10 2015-08-12 XRpro Sciences, Inc. X-ray microscope
EP2074230B1 (en) 2006-10-11 2012-11-28 Janssen Pharmaceutica NV Compositions and methods for treating and diagnosing irritable bowel syndrome
US20080167532A1 (en) * 2006-10-13 2008-07-10 Mayo Foundation For Medical Education And Research Assessing cancer treatment responsiveness
JP2008105973A (ja) * 2006-10-24 2008-05-08 Toyo Kohan Co Ltd ポリペプチド固定化担体の保存方法
WO2008055080A2 (en) * 2006-10-31 2008-05-08 Sru Biosystems, Inc. Method for blocking non-specific protein binding on a functionalized surface
JP2008171800A (ja) * 2006-10-31 2008-07-24 Fei Co 荷電粒子ビーム処理用保護層
WO2008058018A2 (en) 2006-11-02 2008-05-15 Mayo Foundation For Medical Education And Research Predicting cancer outcome
EP2089532A4 (en) * 2006-12-01 2010-02-17 Cedars Sinai Medical Center POSITIVE SELECTION OF SERUM PROTEINS FOR PROTEOM ANALYSIS
US8029902B2 (en) * 2006-12-11 2011-10-04 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups
CA2947292C (en) * 2006-12-27 2019-07-23 Emory University Compositions and methods for the treatment of infections and tumors
KR100894419B1 (ko) * 2006-12-29 2009-04-24 삼성전자주식회사 바이오칩 키트 및 바이오 시료의 검사 방법
EP2629094A1 (en) 2007-01-24 2013-08-21 Carnegie Mellon University Optical biosensors
US20090053690A1 (en) * 2007-02-02 2009-02-26 California Institute Of Technology Surface chemistry and deposition techniques
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
TW200837349A (en) * 2007-03-07 2008-09-16 Nat Univ Tsing Hua Biochip and manufacturing method thereof
KR100836206B1 (ko) 2007-03-20 2008-06-09 연세대학교 산학협력단 패턴형성용 폴리에틸렌글리콜 하이드로젤과 이의 제조방법
JP4850855B2 (ja) * 2007-03-22 2012-01-11 信越化学工業株式会社 マイクロアレイ作製用基板の製造方法
US8399047B2 (en) 2007-03-22 2013-03-19 The Regents Of The Univeristy Of Michigan Multifunctional CVD coatings
AU2008236810A1 (en) 2007-03-27 2008-10-16 Board Of Regents Of The University Of Texas System Biomarkers for ovarian cancer
US20080242559A1 (en) * 2007-03-28 2008-10-02 Northwestern University Protein and peptide arrays
JP5656339B2 (ja) * 2007-03-28 2015-01-21 Jsr株式会社 タンパク質固定化担体およびその製造方法
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US8093039B2 (en) * 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
JP2010525334A (ja) * 2007-04-19 2010-07-22 エス アール ユー バイオシステムズ,インコーポレイテッド 固定化された標的と直接結合する小分子を検出するためにバイオセンサーを使用する方法
EP2148930A4 (en) * 2007-04-19 2010-06-16 Univ Alberta METHOD OF DISTINCTING THROUGH ANTIBODY-RELATED TISSUE EXTRACTION OF T-CELL-RELATED TISSUE EXHAUST
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
EP2639316A1 (en) 2007-05-11 2013-09-18 The Johns Hopkins University Biomarkers for melanoma
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
WO2008143351A1 (en) * 2007-05-18 2008-11-27 Fujirebio Inc. Chemical surface nanopatterns to increase activity of surface-immobilized biomolecules
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
EP2160478B1 (en) * 2007-06-06 2014-08-27 Siemens Healthcare Diagnostics Inc. Predictive diagnostics for kidney disease
KR100927886B1 (ko) * 2007-06-18 2009-11-23 한국생명공학연구원 단백질 g-올리고 뉴클레오타이드 결합체
EP2190448B1 (en) 2007-06-22 2016-04-20 Children's Medical Center Corporation Methods and uses thereof of a fragment of saposin a
WO2009003273A1 (en) * 2007-06-29 2009-01-08 The Governors Of The University Of Alberta Assessing tissue rejection
CN101802611A (zh) * 2007-07-11 2010-08-11 Sru生物系统公司 鉴别离子通道调节剂的方法
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US10247736B2 (en) * 2007-07-20 2019-04-02 Brigham Young University Identification and quantification of biomarkers for evaluating the risk of preterm birth
DE102007034993A1 (de) 2007-07-26 2009-01-29 Hanna Diehl Lösliches Cadherin 17 für die Diagnose und Risikostratifizierung von Darmtumor oder Darmkrebs
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
US8354280B2 (en) 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
JP5723154B2 (ja) 2007-09-19 2015-05-27 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー RNAiにおけるオフターゲット表現型の影響を減少させるためのSiRNA配列非依存性修飾フォーマットおよびその安定化型
EP2201353A4 (en) 2007-09-28 2011-01-26 Caldera Pharmaceuticals Inc METHOD AND DEVICE FOR MEASURING POST-TRANSLATIONAL PROTEIN MODIFICATION
WO2009058867A2 (en) * 2007-10-29 2009-05-07 Primorigen Biosciences, Llc Affinity measurements using frameless multiplexed microarrays
CN101932728B (zh) * 2007-11-30 2013-06-19 西门子医疗保健诊断公司 脂连蛋白受体片段和使用方法
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
US20090181857A1 (en) * 2008-01-15 2009-07-16 Academia Sinica System and method for producing a label-free micro-array biochip
KR100959831B1 (ko) 2008-01-18 2010-05-28 포항공과대학교 산학협력단 패턴인식형 다중생물분자 검출판
US20090196852A1 (en) * 2008-02-04 2009-08-06 Watkinson D Tobin Compositions and methods for diagnosing and treating immune disorders
DE102008011850A1 (de) 2008-02-29 2009-09-03 Michael Grzendowski Biomarker für die Diagnose von Hirntumor
EP3156925A3 (en) 2008-03-10 2017-06-21 Lineagen, Inc. Copd biomarker signatures
JP5818440B2 (ja) 2008-03-12 2015-11-18 オタゴ イノベーション リミテッド バイオマーカー
EP2265642A4 (en) 2008-03-12 2012-05-02 Otago Innovation Ltd BIOMARKERS
WO2009118343A1 (en) * 2008-03-27 2009-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for determining the occurrence of a liver disease in a subject
WO2009121034A2 (en) * 2008-03-28 2009-10-01 Pelican Group Holdings, Inc. Multicapillary sample preparation devices and methods for processing analytes
US8257936B2 (en) * 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
US20090286692A1 (en) * 2008-04-15 2009-11-19 Wainwright Norman R Cartridge and Method for Sample Analysis
US20090263905A1 (en) * 2008-04-18 2009-10-22 Kim Scheuringer Detection test assembly for detecting the presence of a substance in a sample
JP5646457B2 (ja) 2008-04-29 2014-12-24 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリン及びその使用
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
EP2291553A4 (en) 2008-05-28 2011-12-14 Genomedx Biosciences Inc SYSTEMS AND METHODS FOR THE EXPRESSION-BASED DISTINCTION OF DIFFERENT CLINICAL ILLICIT STADIAS IN PROSTATE CANCER
US20090298082A1 (en) * 2008-05-30 2009-12-03 Klee George G Biomarker panels for predicting prostate cancer outcomes
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
NZ589434A (en) 2008-06-03 2012-11-30 Abbott Lab Dual variable domain immunoglobulins and uses thereof
EP2304500A1 (en) * 2008-06-04 2011-04-06 SRU Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
NZ589557A (en) * 2008-06-04 2012-08-31 Talecris Biotherapeutics Inc Immobilised streptokinase, method and kit for preparing plasmin
CA2726894A1 (en) 2008-06-27 2009-12-30 Duke University Therapeutic agents comprising elastin-like peptides
US8021850B2 (en) * 2008-07-14 2011-09-20 Ribo Guo Universal tandem solid-phases based immunoassay
WO2010123608A2 (en) 2009-01-29 2010-10-28 The Regents Of The University Of California A spatial biomarker of disease and detection of spatial organization of cellular recptors
US8476008B2 (en) * 2008-07-23 2013-07-02 Diabetomics, Llc Methods for detecting pre-diabetes and diabetes
JP5781436B2 (ja) 2008-08-11 2015-09-24 バンヤン・バイオマーカーズ・インコーポレーテッド 神経学的状態のバイオマーカー検出方法およびアッセイ
AU2009296528A1 (en) 2008-09-24 2010-04-01 Straus Holdings Inc. Imaging analyzer for testing analytes
BRPI0921043A2 (pt) 2008-11-12 2018-08-07 Caris Life Sciences Luxembourg Holdings métodos e sistemas para usar exossomas para determinar fenótipos
JP5520961B2 (ja) * 2008-11-28 2014-06-11 エモリー ユニバーシティ 感染症および腫瘍を処置するための方法
JP4911639B2 (ja) * 2008-12-02 2012-04-04 学校法人早稲田大学 バイオセンシング方法及び固定化方法
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
US20100166739A1 (en) * 2008-12-30 2010-07-01 Lipella Paharmaceuticals Inc. Methods and Compositions for Diagnosing Urological Disorders
CN102272326B (zh) 2008-12-30 2014-11-12 森托科尔奥索生物科技公司 预测强直性脊柱炎患者对于抗TNFα抗体的临床反应的血清标记物
AU2010208394A1 (en) 2009-01-27 2011-09-08 Hologic, Inc. Biomarkers for detection of neonatal sepsis in biological fluid
WO2010087985A2 (en) 2009-01-28 2010-08-05 Yale University Novel markers for detection of complications resulting from in utero encounters
US9958442B2 (en) 2009-02-11 2018-05-01 Duke University Sensors incorporating antibodies and methods of making and using the same
ES2552337T3 (es) 2009-03-03 2015-11-27 Grifols Therapeutics Inc. Procedimientos para la preparación de plasminógeno
KR101579771B1 (ko) 2009-03-05 2015-12-28 애브비 인코포레이티드 Il-17 결합 단백질
US20120077696A1 (en) 2009-03-15 2012-03-29 Technion Research And Development Foundation Ltd. Soluble hla complexes for use in disease diagnosis
US8865648B2 (en) 2009-04-23 2014-10-21 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
US8741581B2 (en) 2009-04-27 2014-06-03 Technion Research And Development Foundation Ltd. Markers for cancer detection
US20100273185A1 (en) * 2009-04-27 2010-10-28 Sru Biosystems, Inc. Detection of Biased Agonist Activation
WO2010127247A1 (en) * 2009-05-01 2010-11-04 University Of Utah Research Foundation Methods and compositions for measuring high affinity interactions with kinetic imaging of single molecule interaction (kismi)
AU2010248784A1 (en) * 2009-05-15 2011-12-01 Sru Biosystems, Inc Detection of changes in cell populations and mixed cell populations
KR20120034683A (ko) * 2009-05-29 2012-04-12 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 자가면역 t-세포의 분리 및 처리를 위한 펩토이드 리간드
CA2764153C (en) * 2009-06-02 2021-07-27 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
EP2443459B1 (en) * 2009-06-19 2018-12-26 The Arizona Board of Regents, A Body Corporate Of the State of Arizona acting for and on behalf Of Arizona State University Compound arrays for sample profiling
GB0912231D0 (en) * 2009-07-14 2009-08-26 Imp Innovations Ltd Method and apparatus for determining an analyte parameter
US8685755B2 (en) * 2009-07-20 2014-04-01 The Board Of Regents Of The University Of Texas System Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules
EP3311828B1 (en) 2009-08-14 2021-04-07 Phasebio Pharmaceuticals, Inc. Modified vasoactive intestinal peptides
EP2504024A2 (de) 2009-09-27 2012-10-03 Ruhr-Universität Bochum Verfahren zur therapie und diagnose von morbus alzheimer
EP2488543A1 (en) * 2009-10-16 2012-08-22 The Board of Regents of The University of Texas System Compositions and methods for producing cyclic peptoid libraries
KR101105328B1 (ko) * 2009-11-23 2012-01-16 한국표준과학연구원 분자 흡착 및 해리 동특성 측정장치 및 측정방법
CN102667486B (zh) 2009-11-25 2016-03-09 霍洛吉克股份有限公司 羊膜内感染的检测
EP3925670A1 (en) 2009-12-17 2021-12-22 Children's Medical Center, Corp. Saposin-a derived peptides and uses thereof
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
JP4921615B2 (ja) * 2010-01-25 2012-04-25 パナソニック株式会社 プロテインaを自己組織化膜上に固定する方法
US9682132B2 (en) 2010-01-26 2017-06-20 Banyan Biomarkers, Inc Compositions and methods relating to argininosucccinate synthetase
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
WO2011112993A2 (en) 2010-03-11 2011-09-15 University Of Louisville Research Foundation, Inc. Methods of predicting and decreasing the risk of pregnancy loss
US20110229921A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
US20110237535A1 (en) * 2010-03-26 2011-09-29 Sru Biosystems, Inc. Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
EP2564200B8 (en) 2010-04-27 2019-10-02 The Regents of The University of California Cancer biomarkers and methods of use thereof
PL2571532T3 (pl) 2010-05-14 2017-10-31 Abbvie Inc Białka wiążące IL-1
US9211542B2 (en) * 2010-05-21 2015-12-15 Eidgenossische Technische Hochschule Zurich High-density sample support plate for automated sample aliquoting
WO2011163558A1 (en) 2010-06-25 2011-12-29 Abbott Laboratories Materials and methods for assay of anti-hepatitis c virus (hcv) antibodies
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
NZ707637A (en) 2010-07-19 2016-09-30 Otago Innovation Ltd Signal biomarkers
KR101045209B1 (ko) * 2010-07-26 2011-06-30 삼성전자주식회사 고정화 영역을 갖는 포토레지스트 막을 포함하는 어레이 장치 및 이를 이용한 표적 물질 검출방법
SG188190A1 (en) 2010-08-03 2013-04-30 Abbott Lab Dual variable domain immunoglobulins and uses thereof
JP5149992B2 (ja) * 2010-08-30 2013-02-20 パナソニック株式会社 ストレプトアビジンを自己組織化膜上に固定する方法
CN103459611B (zh) 2010-09-17 2016-11-02 哈佛大学校长及研究员协会 对多能干细胞的效用和安全性进行表征的功能基因组学研究
EP2628013B1 (en) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarkers of brain injury
CN103124786A (zh) * 2010-10-19 2013-05-29 松下电器产业株式会社 将葡萄糖氧化酶固定在自组装膜上的方法
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
CN102486474B (zh) * 2010-12-06 2014-05-28 北京大学人民医院 干扰素治疗慢性丙型肝炎转归预测蛋白芯片
SG10201604699VA (en) 2010-12-21 2016-07-28 Abbvie Inc Il-1 -alpha and -beta bispecific dual variable domain immunoglobulins and their use
CA2830407C (en) 2011-03-15 2021-08-31 University Of Utah Research Foundation Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
US8735175B2 (en) * 2011-03-18 2014-05-27 Chris D. Geddes Multicolor microwave-accelerated metal-enhanced fluorescence (M-MAMEF)
EP2694968B1 (en) 2011-04-08 2018-11-21 The General Hospital Corporation Fungal-derived carbohydrate-conjugated scaffold
EP2697653B1 (en) 2011-04-15 2016-03-30 Children's Medical Center Corporation Diagnostic markers and therapeutic targets of kawasaki disease
KR101158362B1 (ko) 2011-04-20 2012-06-22 한국과학기술원 세포 환경 내에서의 단일 분자 수준의 단백질-단백질 상호작용 분석 방법
EP2707389B1 (en) 2011-05-12 2019-10-30 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
ES2669190T3 (es) 2011-06-06 2018-05-24 Phasebio Pharmaceuticals, Inc. Uso de péptidos intestinales vasoactivos modificados en el tratamiento de la hipertensión
CN103492879B (zh) * 2011-06-10 2015-04-01 松下健康医疗控股株式会社 将抗体固定到自组装膜上的方法
AU2012271858B2 (en) * 2011-06-13 2017-05-25 Indevr, Inc. Low density microarrays for vaccine related protein quantification, potency determination and efficacy evaluation
CN102279261B (zh) * 2011-06-20 2013-09-18 东南大学 一种图案编码微载体的喷墨打印制备方法
WO2013003112A1 (en) 2011-06-27 2013-01-03 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
WO2013005269A1 (ja) * 2011-07-05 2013-01-10 パナソニック株式会社 アルブミンを自己組織化膜上に固定する方法
CN103534592A (zh) * 2011-07-08 2014-01-22 松下电器产业株式会社 将蛋白固定到自组装膜上的方法
WO2013041901A1 (en) * 2011-09-20 2013-03-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preparing single domain antibody microarrays
WO2013055829A1 (en) * 2011-10-11 2013-04-18 Nestec S.A. Proximity-based assays for the detection of signaling protein expression and activation
RU2014121043A (ru) 2011-10-24 2015-12-10 Эббви Инк. Биспецифические иммуносвязывающие средства, направленные против tnf и il-17
SG11201401791WA (en) 2011-10-24 2014-08-28 Abbvie Inc Immunobinders directed against sclerostin
PL2776550T3 (pl) 2011-11-07 2018-05-30 Rapid Micro Biosystems, Inc. Kaseta do badania sterylności
BR112014011491A2 (pt) 2011-11-14 2017-05-09 Nestec Sa ensaios e métodos para seleção de um regime de tratamento para um indivíduo com depressão
US10513737B2 (en) 2011-12-13 2019-12-24 Decipher Biosciences, Inc. Cancer diagnostics using non-coding transcripts
EP4306123A3 (en) 2011-12-22 2024-04-17 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
EP2805167B1 (en) 2012-01-20 2020-04-22 Adelaide Research & Innovation Pty Ltd Biomarkers for gastric cancer and uses thereof
EP2812344A4 (en) 2012-02-07 2015-10-28 Vibrant Holdings Llc SUBSTRATES, PEPTIDE NETWORKS AND METHODS
IN2014DN08537A (enExample) 2012-03-20 2015-05-15 Otago Innovation Ltd
CA3171698C (en) 2012-04-16 2025-11-18 Rapid Micro Biosystems, Inc. CELL CULTURE DEVICE
US20150191772A1 (en) 2012-06-29 2015-07-09 Danmarks Tekniske Universitet Method of charging a test carrier and a test carrier
WO2014011955A2 (en) 2012-07-12 2014-01-16 Abbvie, Inc. Il-1 binding proteins
US20150309036A1 (en) 2012-08-16 2015-10-29 The Trustees Of Columbia University In The City Of New York Diagnostic Markers of Indolent Prostate Cancer
EP2885640B1 (en) 2012-08-16 2018-07-18 Genomedx Biosciences, Inc. Prostate cancer prognostics using biomarkers
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
JP6404822B2 (ja) 2012-10-23 2018-10-17 カリス ライフ サイエンシズ スウィッツァーランド ホールディングス ゲーエムベーハー アプタマーおよびその使用
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
WO2014071456A1 (en) 2012-11-08 2014-05-15 The Macfarlane Burnet Institute For Medical Research And Public Health Ltd Diagnostic, prognostic, therapeutic and screening protocols
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
AU2013202668B2 (en) 2012-12-24 2014-12-18 Adelaide Research & Innovation Pty Ltd Inhibition of cancer growth and metastasis
US9086412B2 (en) 2012-12-31 2015-07-21 University Of Louisville Research Foundation, Inc. Extracellular vesicle-associated protein markers of cancer
CN105228649B (zh) 2013-03-14 2019-01-18 雅培制药有限公司 Hcv抗原-抗体组合测定和方法以及用在其中的组合物
JP2016512241A (ja) 2013-03-14 2016-04-25 アボット・ラボラトリーズAbbott Laboratories 改良された抗体検出のためのhcvns3組換え抗原およびこの突然変異体
CA2906417C (en) 2013-03-14 2022-06-21 Robert Ziemann Hcv core lipid binding domain monoclonal antibodies
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
WO2014182896A1 (en) 2013-05-10 2014-11-13 Johns Hopkins University Compositions for ovarian cancer assessment having improved specificity
DE102013210138A1 (de) 2013-05-30 2014-12-04 Boehringer Ingelheim Vetmedica Gmbh Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen
JP2014235115A (ja) * 2013-06-04 2014-12-15 ウシオ電機株式会社 マイクロチップおよびマイクロチップにおける金属薄膜の成膜方法
US10534003B2 (en) 2013-07-17 2020-01-14 The Johns Hopkins University Multi-protein biomarker assay for brain injury detection and outcome
AU2014312211A1 (en) 2013-08-28 2016-03-10 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2015130968A2 (en) 2014-02-27 2015-09-03 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
WO2015187227A2 (en) 2014-03-13 2015-12-10 Duke University Electronic platform for sensing and control of electrochemical reactions
CA2947982C (en) 2014-05-08 2022-11-29 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
US10732180B2 (en) 2014-06-04 2020-08-04 Indevr, Inc. Universal capture array for multiplexed subtype-specific quantification and stability determination of influenza proteins
AU2015276899B2 (en) 2014-06-19 2021-08-12 Memorial Sloan-Kettering Cancer Center Biomarkers for response to EZH2 inhibitors
US9694518B2 (en) 2014-06-20 2017-07-04 The Regents Of The University Of Michigan Breath-activated images and anti-counterfeit authentication features formed of nanopillar arrays
JP2017521654A (ja) 2014-06-27 2017-08-03 アボット・ラボラトリーズAbbott Laboratories ヒトペギウイルス2(HPgV−2)を検出するための組成物および方法
WO2016011383A1 (en) 2014-07-17 2016-01-21 The Trustees Of The University Of Pennsylvania Methods for using exosomes to monitor transplanted organ status
US20160032281A1 (en) * 2014-07-31 2016-02-04 Fei Company Functionalized grids for locating and imaging biological specimens and methods of using the same
WO2016044697A1 (en) 2014-09-19 2016-03-24 The Johns Hopkins University Biomarkers of cognitive dysfunction
EP3213083B1 (en) 2014-10-29 2020-08-19 Abbott Laboratories Subject anti-hcv antibody detection assays employing ns3 capture peptides
KR101687950B1 (ko) * 2014-11-14 2016-12-21 연세대학교 산학협력단 표면 개질된 진단용 플레이트, 상기 표면 개질된 진단용 플레이트의 제조방법, 및 상기 표면 개질된 진단용 플레이트를 이용한 진단 방법
EP3224380A1 (en) 2014-11-25 2017-10-04 The Broad Institute Inc. Clonal haematopoiesis
WO2016086197A1 (en) 2014-11-25 2016-06-02 The Brigham And Women's Hospital, Inc. Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
WO2016109378A1 (en) 2014-12-29 2016-07-07 North Carolina State University Multiplexed diagnostic to recognize concentrations of related proteins and peptides
CN107427556B (zh) 2015-02-09 2022-02-25 费斯生物制药公司 用于治疗肌肉疾病和病症的方法和组合物
EP3259594A4 (en) 2015-02-20 2018-12-26 The Johns Hopkins University Biomarkers of myocardial injury
EP3262193A2 (en) 2015-02-26 2018-01-03 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
US20180045734A1 (en) * 2015-03-06 2018-02-15 Tymora Analytical Operations Llc Chemically functionalized array to analyze protein modifications
AU2016229076B2 (en) 2015-03-09 2022-01-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
US10294451B2 (en) 2015-04-22 2019-05-21 University Of Maryland, Baltimore County Flow and static lysing systems and methods for ultra-rapid isolation and fragmentation of biological materials by microwave irradiation
IL256634B2 (en) 2015-06-29 2025-08-01 Caris Science Inc Therapeutic oligonucleotides
JP2018523469A (ja) 2015-07-10 2018-08-23 ウエストバージニア ユニバーシティWest Virginia University 脳卒中および脳卒中重篤度のマーカー
WO2017015531A1 (en) 2015-07-22 2017-01-26 University Of Maryland, Baltimore County Hydrophilic coatings of plasmonic metals to enable low volume metal-enhanced fluorescence
WO2017019918A1 (en) 2015-07-28 2017-02-02 Caris Science, Inc. Targeted oligonucleotides
DE102015114026A1 (de) 2015-08-24 2017-03-02 Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. Biomarker-Panel für die Diagnose von rezidivem Prostatakrebs
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
DK3356558T3 (da) 2015-09-30 2022-04-25 Immunexpress Pty Ltd Sirs patogenbiomarkører og anvendelser deraf
KR20180088722A (ko) 2015-12-02 2018-08-06 베링거잉겔하임베트메디카게엠베하 칩 상에 다수의 측정 영역들을 제조하는 방법 및 다수의 측정 영역들을 갖는 칩
WO2017099829A1 (en) 2015-12-11 2017-06-15 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
AU2016377391B2 (en) 2015-12-24 2022-09-01 Immunexpress Pty Ltd Triage biomarkers and uses therefor
WO2017161357A1 (en) 2016-03-18 2017-09-21 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP3464597B1 (en) 2016-05-25 2022-08-03 Caris Science, Inc. Oligonucleotide probe selection method and uses thereof
EP3472181A4 (en) 2016-06-20 2020-05-13 Healthtell Inc. METHOD FOR DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES
WO2017223116A2 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
JP6420281B2 (ja) * 2016-07-04 2018-11-07 花王株式会社 タンパク質解析用固相担体及びその製造方法
US11414708B2 (en) 2016-08-24 2022-08-16 Decipher Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
CN110366558A (zh) 2016-10-28 2019-10-22 班扬生物标记公司 针对泛素c末端水解酶l1(uch-l1)和胶质纤维酸性蛋白(gfap)的抗体及相关方法
US11448648B2 (en) 2016-11-11 2022-09-20 Ascendant Diagnostics, LLC Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and Kawasaki disease
AU2017357818A1 (en) 2016-11-11 2019-05-30 HealthTell, Inc. Methods for identifying candidate biomarkers
CA3050984A1 (en) 2017-01-20 2018-07-26 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
WO2018165600A1 (en) 2017-03-09 2018-09-13 Genomedx Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
US20200131576A1 (en) 2017-04-25 2020-04-30 The Brigham And Women's Hospital, Inc. IL-8, IL-6, IL-1 Beta and TET2 and DNMT3A in Atherosclerosis
CA3062716A1 (en) 2017-05-12 2018-11-15 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
CA3072061A1 (en) 2017-08-04 2019-02-07 The Regents Of The University Of Michigan Use of immune cell-specific gene expression for prognosis of prostate cancer and prediction of responsiveness to radiation therapy
EA202090427A1 (ru) 2017-08-16 2020-06-08 МЕДИММЬЮН, ЭлЭлСи Композиции и способы лечения атопического дерматита и выбора лечения
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
WO2019094798A1 (en) 2017-11-10 2019-05-16 The Trustees Of Columbia University In The City Of New York Methods and compositions for promoting or inducing hair growth
EP3756010A4 (en) 2018-02-20 2021-11-03 Pavonis Diagnostics Inc. ALUMINUM OXIDE SURFACES AND INTERFACE MOLECULES
CN112740017B (zh) 2018-04-19 2024-12-13 曙光诊断学公司 靶标检测
EP3790985A4 (en) 2018-05-09 2022-02-16 Vibrant Holdings, LLC METHOD OF SYNTHESIS OF A POLYNUCLEOTIDARRAY USING PHOTOACTIVATED AGENTS
KR20210014109A (ko) 2018-05-10 2021-02-08 더 메서디스트 하스피틀 질환의 예후와 관리 방법
BR112020024715A2 (pt) 2018-06-04 2021-03-23 Avon Products. Inc. biomarcadores proteicos para identificar e tratar o envelhecimento da pele e afecções cutâneas
CA3112792A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
EP3860452A4 (en) 2018-10-04 2022-11-23 First Light Diagnostics, Inc. ANALYTICAL TOOL
WO2020096631A2 (en) 2018-11-07 2020-05-14 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
US12121829B2 (en) 2019-02-27 2024-10-22 Waters Technologies Corporation Chromatographic seal and coated flow paths for minimizing analyte adsorption
GB201904697D0 (en) 2019-04-03 2019-05-15 Vib Vzw Means and methods for single molecule peptide sequencing
JP7441303B2 (ja) 2019-08-05 2024-02-29 シアー, インコーポレイテッド サンプル調製、データ生成、タンパク質コロナ分析のためのシステムおよび方法
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer
US12018279B2 (en) 2019-10-18 2024-06-25 The Trustees Of The University Of Pennsylvania Micro-engineered models of the human eye and methods of use
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
EP4185301A4 (en) 2020-07-24 2025-05-07 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules
WO2022072479A1 (en) 2020-09-29 2022-04-07 The Johns Hopkins University Integrated proteomic biomarkers for the detection of aggressive prostate cancer
EP4074820A1 (en) 2021-04-16 2022-10-19 The Trustees of The University of Pennsylvania Micro-engineered models of the human eye and methods of use
WO2023288108A1 (en) * 2021-07-16 2023-01-19 The University Of Chicago Biocompatible surface for quantum sensing and methods thereof
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
US20240068941A1 (en) * 2022-08-24 2024-02-29 Miami University Label-free bacterial detection
WO2024184407A1 (en) 2023-03-06 2024-09-12 Vib Vzw Method for identifying tumor-specific cell surface o-glycopeptides
WO2025106804A1 (en) 2023-11-16 2025-05-22 Massachusetts Institute Of Technology Compositions and methods for characterizing hepatocyte stress
WO2025217069A1 (en) 2024-04-08 2025-10-16 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating cardiotoxicity

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071409A (en) 1976-05-20 1978-01-31 Corning Glass Works Immobilization of proteins on inorganic support materials
US4722896A (en) 1981-01-26 1988-02-02 The Beth Israel Hospital Association Method for affinity purification of hybridoma antibodies
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US4690715A (en) 1982-06-18 1987-09-01 American Telephone And Telegraph Company, At&T Bell Laboratories Modification of the properties of metals
US4514508A (en) * 1982-07-06 1985-04-30 Biond Inc. Assaying for a multiplicity of antigens or antibodies with a detection compound
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4608112A (en) * 1984-05-16 1986-08-26 The United States Of America As Represented By The Secretary Of The Air Force Mask aligner for solar cell fabrication
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US5523215A (en) * 1985-03-28 1996-06-04 Chiron Corporation Enhanced purification and expression of insoluble recombinant proteins
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US4894146A (en) * 1986-01-27 1990-01-16 University Of Utah Thin channel split flow process and apparatus for particle fractionation
US4802951A (en) * 1986-03-07 1989-02-07 Trustees Of Boston University Method for parallel fabrication of nanometer scale multi-device structures
US5643948A (en) * 1986-06-11 1997-07-01 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. K.
US5637489A (en) * 1986-08-23 1997-06-10 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US4859538A (en) 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
US5079600A (en) 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US4928112A (en) * 1987-03-23 1990-05-22 Howtek, Inc. Ink curing apparatus
US5154808A (en) 1987-06-26 1992-10-13 Fuji Photo Film Co., Ltd. Functional organic thin film and process for producing the same
US4987032A (en) 1987-06-26 1991-01-22 Fuji Photo Film Co., Ltd. Functional organic thin film and method of manufacture thereof
DE3733190A1 (de) * 1987-10-01 1989-04-13 Kugelfischer G Schaefer & Co Mehrreihiges kugel- oder rollenlager bzw. kombiniertes kugel-rollenlager
US6692751B1 (en) * 1988-05-06 2004-02-17 New York Blood Center Methods and systems for producing recombinant viral antigens
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5281540A (en) * 1988-08-02 1994-01-25 Abbott Laboratories Test array for performing assays
US5720928A (en) * 1988-09-15 1998-02-24 New York University Image processing and analysis of individual nucleic acid molecules
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
JPH02272081A (ja) * 1989-04-14 1990-11-06 Fuji Photo Film Co Ltd 機能性有機薄膜
IT1229691B (it) 1989-04-21 1991-09-06 Eniricerche Spa Sensore con antigene legato chimicamente a un dispositivo semiconduttore.
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DE3939973A1 (de) 1989-12-02 1991-06-06 Basf Ag Zweidimensional kristallisierte makromolekuelschichten
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
DE59108783D1 (de) 1990-04-12 1997-08-21 Hans Dr Sigrist Verfahren zur lichtinduzierten immobilisierung von biomolekülen an chemisch "inerten" oberflächen
US5861254A (en) * 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
WO1992008788A1 (en) * 1990-11-19 1992-05-29 The Board Of Trustees Of The University Of Illinois Mutant orientable proteins and coated substrates
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
EP0834575B1 (en) * 1990-12-06 2001-11-28 Affymetrix, Inc. (a Delaware Corporation) Identification of nucleic acids in samples
US5384886A (en) * 1991-04-01 1995-01-24 Xerox Corporation Process for electronically printing envelopes
US5763170A (en) * 1991-04-16 1998-06-09 Amersham International Plc Method for forming an array of biological particles
US5516635A (en) * 1991-10-15 1996-05-14 Ekins; Roger P. Binding assay employing labelled reagent
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
WO1993009668A1 (en) * 1991-11-22 1993-05-27 Affymax Technology N.V. Combinatorial strategies for polymer synthesis
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
ES2341666T3 (es) * 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
DE59108591D1 (de) 1991-12-06 1997-04-10 Ciba Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
CA2064683A1 (en) 1992-03-26 1993-09-27 Krishna Mohan Rao Kallury Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices
EP0637384B1 (en) 1992-04-22 1996-10-02 Ecole Polytechnique Federale De Lausanne Lipid membrane sensors
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
JPH0641183A (ja) 1992-07-23 1994-02-15 Mitsubishi Kasei Corp オリゴヌクレオチド単分子膜
DE4237113B4 (de) * 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
CA2108705A1 (en) * 1992-11-06 1994-05-07 Richard Barner Biologically recognizing layers on new ti02 waveguide for biosensors
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5532142A (en) * 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
DE69432791T2 (de) 1993-05-28 2004-06-03 Baylor College Of Medicine, Houston Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5861242A (en) 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
US5441876A (en) 1993-07-30 1995-08-15 The United States Of America As Represented By The Secretary Of The Navy Process for the preparation of headgroup-modified phospholipids using phosphatidylhydroxyalkanols as intermediates
WO1995004069A1 (en) * 1993-07-30 1995-02-09 Affymax Technologies N.V. Biotinylation of proteins
RU2041262C1 (ru) * 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
JPH0784372A (ja) 1993-09-17 1995-03-31 Res Dev Corp Of Japan 有機シラン修飾酸化物と修飾表面 光パターニング酸化物
DE4332003C2 (de) 1993-09-21 1996-02-22 Seeger Stefan Verfahren zur Beschichtung von Oberflächen mit Biomolekülen und anderen Rezeptormolekülen
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
PT725682E (pt) * 1993-10-28 2002-09-30 Houston Advanced Res Ct Dispositivo poroso microfabricado de escoamento
US5429708A (en) 1993-12-22 1995-07-04 The Board Of Trustees Of The Leland Stanford Junior University Molecular layers covalently bonded to silicon surfaces
EP0664452B1 (de) * 1994-01-19 2002-07-31 Roche Diagnostics GmbH Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
DE4435728A1 (de) * 1994-01-19 1995-07-20 Boehringer Mannheim Gmbh Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
US5623055A (en) * 1994-01-28 1997-04-22 Prolinx, Inc. Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
JPH09509485A (ja) 1994-02-09 1997-09-22 アボツト・ラボラトリーズ 診断用フローセルデバイス
US5514501A (en) 1994-06-07 1996-05-07 The United States Of America As Represented By The Secretary Of Commerce Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
AU2897595A (en) 1994-07-14 1996-02-16 Technobiochip Biosensor and method and instrument for deposition of alternating monomolecular layers
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
SE9403245D0 (sv) 1994-09-26 1994-09-26 Pharmacia Biosensor Ab Improvements relating to bilayer lipid membranes
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5688642A (en) 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5622826A (en) 1994-12-22 1997-04-22 Houston Advanced Research Center Method for immobilization of molecules on platinum solid support surfaces
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
WO1996029629A2 (en) 1995-03-01 1996-09-26 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
US5629213A (en) 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
WO1996027614A1 (en) 1995-03-08 1996-09-12 Elias Klein Surface modified affinity separation membrane
CZ299135B6 (cs) * 1995-03-10 2008-04-30 Meso Scale Technologies, Llc. Corporation Servicecompany Kazeta a zarízení pro použití pri detekci analytu, zpusob provádení testu za použití uvedené kazety, kit pro použití pri provádení množiny elektrochemiluminescencních testu a zpusob detekce nebo merení analytu
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6309820B1 (en) * 1995-04-07 2001-10-30 University Of North Carolina At Chapel Hill Polypeptides having a functional domain of interest and methods of identifying and using same
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5625184A (en) * 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
WO1996038726A1 (en) 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Covalently immobilized phospholipid bilayers on solid surfaces
US5776674A (en) 1995-06-05 1998-07-07 Seq, Ltd Chemical biochemical and biological processing in thin films
EP0836418A1 (en) 1995-06-07 1998-04-22 The Regents Of The University Of California Microfabricated devices for diagnostic applications
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
AU6774996A (en) 1995-08-18 1997-03-12 President And Fellows Of Harvard College Self-assembled monolayer directed patterning of surfaces
CA2187969C (en) * 1995-10-17 2006-05-30 Dale L. Boger A template for solution phase synthesis of combinatorial libraries
DE19543232A1 (de) 1995-11-07 1997-05-15 Knoell Hans Forschung Ev Herstellung einer Matrix-gebundenen miniaturisierten kombinatorischen Poly- und Oligomerbibliothek
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
AU719454B2 (en) 1995-12-01 2000-05-11 Innogenetics N.V. Impedimetric detection system and method of production thereof
DE19548152A1 (de) 1995-12-22 1997-06-26 Boehringer Mannheim Gmbh Verfahren zur Bedeckung einer Oberfläche mit einem Film eines Oligoethylenglykolderivates
WO1997033737A1 (en) 1996-03-15 1997-09-18 President And Fellows Of Harvard College Method of forming articles and patterning surfaces via capillary micromolding
AU706862B2 (en) 1996-04-03 1999-06-24 Applied Biosystems, Llc Device and method for multiple analyte detection
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5925552A (en) 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
JP2000510233A (ja) 1996-04-25 2000-08-08 ペンス,インコーポレイテッド バイオセンサ装置および方法
US5731152A (en) 1996-05-13 1998-03-24 Motorola, Inc. Methods and systems for biological reagent placement
US6075875A (en) * 1996-09-30 2000-06-13 Microsoft Corporation Segmentation of image features using hierarchical analysis of multi-valued image data and weighted averaging of segmentation results
US20030017149A1 (en) * 1996-10-10 2003-01-23 Hoeffler James P. Single chain monoclonal antibody fusion reagents that regulate transcription in vivo
GB9624927D0 (en) * 1996-11-29 1997-01-15 Oxford Glycosciences Uk Ltd Gels and their use
WO1998023948A1 (en) 1996-11-29 1998-06-04 The Board Of Trustees Of The Leland Stanford Junior University Arrays of independently-addressable supported fluid bilayer membranes and methods of use thereof
US5905024A (en) * 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
US5837860A (en) 1997-03-05 1998-11-17 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
US6180288B1 (en) * 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
WO1998050773A2 (en) 1997-05-08 1998-11-12 University Of Minnesota Microcantilever biosensor
US6190619B1 (en) * 1997-06-11 2001-02-20 Argonaut Technologies, Inc. Systems and methods for parallel synthesis of compounds
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5948621A (en) * 1997-09-30 1999-09-07 The United States Of America As Represented By The Secretary Of The Navy Direct molecular patterning using a micro-stamp gel
WO1999019510A1 (en) * 1997-10-10 1999-04-22 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
US6061476A (en) * 1997-11-24 2000-05-09 Cognex Corporation Method and apparatus using image subtraction and dynamic thresholding
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
EP1060395B1 (en) 1998-02-04 2008-04-30 Invitrogen Corporation Microarrays and uses therefor
US6087103A (en) * 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
US6350369B1 (en) * 1998-04-14 2002-02-26 California Institute Of Technology Method and system for determining analyte activity
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6682942B1 (en) * 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
US6190908B1 (en) * 1998-08-12 2001-02-20 The Scripps Research Institute Modulation of polypeptide display on modified filamentous phage
AU3387700A (en) 1999-03-02 2000-09-21 Chiron Corporation Microarrays for identifying pathway activation or induction
CA2365431A1 (en) 1999-03-10 2000-09-14 Hui Ge Universal protein array system
AU3883300A (en) 1999-03-11 2000-09-28 Combimatrix Corporation Microarrays of peptide affinity probes for analyzing gene products and methods for analyzing gene products
KR100379411B1 (ko) * 1999-06-28 2003-04-10 엘지전자 주식회사 바이오칩 및 그의 생체 물질 패터닝 및 측정 방법
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6406840B1 (en) * 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US6720157B2 (en) * 2000-02-23 2004-04-13 Zyomyx, Inc. Chips having elevated sample surfaces
US6531283B1 (en) * 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US7094568B2 (en) * 2000-08-17 2006-08-22 Sense Proteomic Ltd. Method for producing proteins tagged at the N- or C-terminus
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US20050095646A1 (en) * 2001-11-19 2005-05-05 Sherman Michael I. Method of using a non-antibody protein to detect and measure an analyte
US20050026215A1 (en) * 2003-07-17 2005-02-03 Predki Paul F. Method for the prediction of an epitope

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