DE60325743D1 - Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten - Google Patents
Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analytenInfo
- Publication number
- DE60325743D1 DE60325743D1 DE60325743T DE60325743T DE60325743D1 DE 60325743 D1 DE60325743 D1 DE 60325743D1 DE 60325743 T DE60325743 T DE 60325743T DE 60325743 T DE60325743 T DE 60325743T DE 60325743 D1 DE60325743 D1 DE 60325743D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- line
- formulae
- polyanion
- polyanionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39325502P | 2002-07-02 | 2002-07-02 | |
PCT/US2003/021021 WO2004004647A2 (en) | 2002-07-02 | 2003-07-02 | Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60325743D1 true DE60325743D1 (de) | 2009-02-26 |
Family
ID=30115557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60325743T Expired - Lifetime DE60325743D1 (de) | 2002-07-02 | 2003-07-02 | Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten |
Country Status (8)
Country | Link |
---|---|
US (2) | US7253277B2 (de) |
EP (1) | EP1540006B1 (de) |
JP (1) | JP2005532456A (de) |
AT (1) | ATE420357T1 (de) |
AU (1) | AU2003247788B2 (de) |
CA (1) | CA2490413C (de) |
DE (1) | DE60325743D1 (de) |
WO (1) | WO2004004647A2 (de) |
Families Citing this family (44)
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US6506564B1 (en) * | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US7169556B2 (en) * | 1996-07-29 | 2007-01-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6750016B2 (en) * | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6984491B2 (en) * | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6582921B2 (en) * | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
US20050037397A1 (en) * | 2001-03-28 | 2005-02-17 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
US6974669B2 (en) * | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
JP2004501340A (ja) * | 2000-01-13 | 2004-01-15 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを付着させたナノ粒子とその使用方法 |
JP3605607B2 (ja) * | 2000-07-11 | 2004-12-22 | ノースウエスタン ユニバーシティ | 銀染色の増強による検出方法 |
US20060040286A1 (en) * | 2001-03-28 | 2006-02-23 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
US20030113740A1 (en) * | 2001-04-26 | 2003-06-19 | Mirkin Chad A. | Oligonucleotide-modified ROMP polymers and co-polymers |
US7147687B2 (en) * | 2001-05-25 | 2006-12-12 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
WO2002096262A2 (en) * | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
AU2002365115A1 (en) * | 2001-07-20 | 2003-09-02 | North Carolina State University | Light addressable electrochemical detection of duplex structures |
US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
WO2004004647A2 (en) * | 2002-07-02 | 2004-01-15 | Nanosphere Inc. | Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes |
US20040180369A1 (en) * | 2003-01-16 | 2004-09-16 | North Carolina State University | Photothermal detection of nucleic acid hybridization |
EP1597399A2 (de) * | 2003-02-27 | 2005-11-23 | Nanosphere, Inc. | Markierungsfreie erstellung von genexpressionsprofilen mittels universeller nanopartikelsonden im mikroarray-testformat |
US20050250094A1 (en) * | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
US20060240573A1 (en) * | 2003-07-29 | 2006-10-26 | Lamdagen, Llc | Optical system including nanostructures for biological or chemical sensing |
WO2005042783A1 (en) * | 2003-10-30 | 2005-05-12 | North Carolina State University | Temperature-jump enhanced electrochemical detection of nucleic acid hybridization |
WO2005042785A1 (en) * | 2003-10-30 | 2005-05-12 | North Carolina State University | Electrochemical detection of nucleic acid hybridization |
JP2008507296A (ja) * | 2004-07-26 | 2008-03-13 | ナノスフェアー インコーポレイテッド | 混合培養物中でメチシリン耐性黄色ブドウ球菌とメチシリン感受性黄色ブドウ球菌とを区別する方法 |
US7583379B2 (en) | 2005-07-28 | 2009-09-01 | University Of Georgia Research Foundation | Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof |
US7738096B2 (en) * | 2004-10-21 | 2010-06-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof |
US20060134806A1 (en) * | 2004-12-20 | 2006-06-22 | General Electric Company | Method of separating unattached Raman-active tag from bioassay or other reaction mixture |
US20070154903A1 (en) * | 2005-06-23 | 2007-07-05 | Nanosphere, Inc. | Selective isolation and concentration of nucleic acids from complex samples |
JP2009505106A (ja) * | 2005-08-19 | 2009-02-05 | ナノスフェアー インコーポレイテッド | Dna及び抗体を含むハイブリッド基板を調製するための方法及びその使用 |
US20070072309A1 (en) * | 2005-09-29 | 2007-03-29 | General Electric Company | Analytical compositions including nanometer-sized transducers, methods to make thereof, and devices therefrom |
JP5400297B2 (ja) * | 2005-12-27 | 2014-01-29 | 古河電気工業株式会社 | 蛍光ナノシリカ粒子、ナノ蛍光材料、それを用いたバイオチップ及びそのアッセイ法 |
US20100234579A1 (en) * | 2007-05-10 | 2010-09-16 | North Western University | Silver nanoparticle binding agent conjugates based on moieties with triple cyclic disulfide anchoring groups |
CA2724552C (en) | 2008-05-27 | 2018-10-09 | Dako Denmark A/S | Compositions and methods for detection of chromosomal aberrations with hybridization buffers comprising a polar aprotic solvent |
WO2010093334A1 (en) * | 2009-02-13 | 2010-08-19 | Agency For Science, Technology And Research | Label-free method for detecting presence or absence of nucleic acids |
WO2010097655A1 (en) | 2009-02-26 | 2010-09-02 | Dako Denmark A/S | Compositions and methods for rna hybridization applications |
WO2010129666A1 (en) * | 2009-05-05 | 2010-11-11 | Altermune Technologies, Llc | Chemically programmable immunity |
FR2952300B1 (fr) * | 2009-11-09 | 2012-05-11 | Oreal | Nouveaux colorants fluorescents a motif heterocyclique disulfure, composition de teinture les comprenant et procede de coloration des fibres keratiniques humaines a partir de ces colorants |
EP2761028A1 (de) | 2011-09-30 | 2014-08-06 | Dako Denmark A/S | Hybridisierungszusammensetzungen und -verfahren mit formamid |
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WO2017027677A1 (en) | 2015-08-11 | 2017-02-16 | University Of Central Florida Research Foundation, Inc. | Passive insect surveillance sensor device |
KR102480247B1 (ko) | 2016-08-25 | 2022-12-21 | 에프. 호프만-라 로슈 아게 | 다관능화된 규소 나노 입자, 이들의 제조 방법 및 전기 화학 발광 기반 검출 방법에서의 이의 용도 |
CN110234600B (zh) * | 2016-10-21 | 2023-03-21 | 美国政府(由卫生和人类服务部的部长所代表) | 分子纳米标签 |
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ATE423975T1 (de) | 2001-08-03 | 2009-03-15 | Nanosphere Inc | Nanopartikelabbildungssystem und -verfahren |
ATE403751T1 (de) | 2001-11-09 | 2008-08-15 | Nanosphere Inc | Biokonjugat-nanopartikelsonden |
US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
US6702411B2 (en) * | 2002-06-21 | 2004-03-09 | Oscar Helver | Hands free cabinet drawer assist system |
WO2004004647A2 (en) | 2002-07-02 | 2004-01-15 | Nanosphere Inc. | Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes |
-
2003
- 2003-07-02 WO PCT/US2003/021021 patent/WO2004004647A2/en active IP Right Grant
- 2003-07-02 DE DE60325743T patent/DE60325743D1/de not_active Expired - Lifetime
- 2003-07-02 AT AT03763192T patent/ATE420357T1/de not_active IP Right Cessation
- 2003-07-02 EP EP03763192A patent/EP1540006B1/de not_active Expired - Lifetime
- 2003-07-02 JP JP2004519869A patent/JP2005532456A/ja active Pending
- 2003-07-02 CA CA2490413A patent/CA2490413C/en not_active Expired - Lifetime
- 2003-07-02 AU AU2003247788A patent/AU2003247788B2/en not_active Ceased
- 2003-07-02 US US10/612,422 patent/US7253277B2/en active Active
-
2007
- 2007-08-06 US US11/890,545 patent/US20080153082A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1540006A4 (de) | 2006-08-09 |
EP1540006B1 (de) | 2009-01-07 |
US20080153082A1 (en) | 2008-06-26 |
CA2490413A1 (en) | 2004-01-15 |
ATE420357T1 (de) | 2009-01-15 |
CA2490413C (en) | 2011-08-30 |
US20040053222A1 (en) | 2004-03-18 |
AU2003247788A1 (en) | 2004-01-23 |
AU2003247788B2 (en) | 2007-04-19 |
EP1540006A2 (de) | 2005-06-15 |
WO2004004647A2 (en) | 2004-01-15 |
JP2005532456A (ja) | 2005-10-27 |
WO2004004647A3 (en) | 2004-03-25 |
US7253277B2 (en) | 2007-08-07 |
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