AU6834700A - Device and method for determining multiple analytes - Google Patents

Device and method for determining multiple analytes

Info

Publication number
AU6834700A
AU6834700A AU68347/00A AU6834700A AU6834700A AU 6834700 A AU6834700 A AU 6834700A AU 68347/00 A AU68347/00 A AU 68347/00A AU 6834700 A AU6834700 A AU 6834700A AU 6834700 A AU6834700 A AU 6834700A
Authority
AU
Australia
Prior art keywords
sample
sealing layer
sample compartments
sensor platform
compartments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU68347/00A
Inventor
Andreas P. Abel
Gert L. Dubeneck
Markus Ehrat
Gerhard M. Kresbach
Michael Pawlak
Eveline Schurmann-Mader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeptosens AG
Original Assignee
Zeptosens AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeptosens AG filed Critical Zeptosens AG
Publication of AU6834700A publication Critical patent/AU6834700A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A device includes a planar optical waveguide, as part of a sensor platform, and, connected to the platform directly or by means of a sealing medium, a sealing layer. The sealing layer forms either directly or by means of a sealing medium a tightly sealing layer. The sealing layer includes a multitude of recesses at least open towards the sensor platform, which form a corresponding multitude of sample compartments in a 2-dimensional arrangement. Each of the sample compartments has different biological or biochemical recognition elements, for the specific recognition and binding of different analytes, immobilized in five or more discrete measurement areas, wherein the measurement areas are in optical interaction with excitation light emanating from the optical waveguide, as part of the sensor platform which forms a demarcation of the sample compartments, and wherein the sample compartments are operable to be cleared from received sample or reagent solutions and to then receive, optionally without washing steps, further sample or reagent solutions, which are supplied to the same sample compartments.
AU68347/00A 1999-08-13 2000-08-03 Device and method for determining multiple analytes Abandoned AU6834700A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1486/99 1999-08-13
CH148699 1999-08-13
PCT/EP2000/007529 WO2001013096A1 (en) 1999-08-13 2000-08-03 Device and method for determining multiple analytes

Publications (1)

Publication Number Publication Date
AU6834700A true AU6834700A (en) 2001-03-13

Family

ID=4211590

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68347/00A Abandoned AU6834700A (en) 1999-08-13 2000-08-03 Device and method for determining multiple analytes

Country Status (7)

Country Link
US (2) US7708945B1 (en)
EP (1) EP1274986B1 (en)
JP (1) JP5006494B2 (en)
AT (1) ATE516492T1 (en)
AU (1) AU6834700A (en)
ES (1) ES2367551T3 (en)
WO (1) WO2001013096A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955837B2 (en) 2005-10-29 2011-06-07 Bayer Technology Services Gmbh Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7423750B2 (en) 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
WO2006053769A1 (en) * 2004-11-18 2006-05-26 Eppendorf Array Technologies Real-time quantification of multiple targets on a micro-array
US6785433B2 (en) 2000-08-09 2004-08-31 Artificial Sensing Instruments Asi Ag Waveguide grid array and optical measurement arrangement
EP1327135B1 (en) 2000-09-04 2010-02-24 Bayer Technology Services GmbH Multianalyte determination system and methods
WO2002020873A2 (en) 2000-09-05 2002-03-14 Zeptosens Ag Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof
JP2003014647A (en) * 2001-07-04 2003-01-15 System Instruments Kk Fluorescence measuring method due to waveguide method having probe substance placed thereon
DE10133844B4 (en) * 2001-07-18 2006-08-17 Micronas Gmbh Method and device for detecting analytes
AU2002352069A1 (en) * 2001-11-28 2003-06-10 Graffinity Pharmaceuticals Ag Surface plasmon resonance (spr) sensor surface support
EP1363119A4 (en) * 2001-12-26 2004-05-26 Matsushita Electric Ind Co Ltd Information measuring device
EP1348757A1 (en) 2002-03-27 2003-10-01 Micronas GmbH Apparatus and method for detecting cellular processes using luminescence measurements
AU2003248273A1 (en) * 2002-07-12 2004-02-02 Mitsubishi Chemical Corporation Analytical chip, analytical chip unit, analyzing apparatus, method of analysis using the apparatus, and method of producing the analytical chip
DE10251893A1 (en) * 2002-11-07 2004-05-19 C-Cit Ag Optical sensor, for quantitative measurement of enzyme activities, has a transparent layer on a carrier with a grid between them to switch electromagnetic waves on/off as a disposable chip
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
US7545494B2 (en) 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
WO2006127056A2 (en) * 2005-05-25 2006-11-30 Bio-Rad Laboratories, Inc. Fluidics device
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US8675199B2 (en) * 2006-03-10 2014-03-18 Plc Diagnostics, Inc. Waveguide-based detection system with scanning light source
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
SE529711C2 (en) * 2006-03-22 2007-11-06 Aamic Ab Fluorescence Readers
JP5258457B2 (en) * 2007-11-21 2013-08-07 株式会社日立ハイテクノロジーズ Optical analyzer
DE102007062250A1 (en) * 2007-12-21 2009-06-25 Evotec Ag Chemical and biological samples e.g. cell, testing device, has set of detecting devices arranged on base element, where each detecting device is attached to individual or group of sample receiving areas
EP2110694B1 (en) * 2008-04-18 2013-08-14 Sony DADC Austria AG Method for manufacturing an optical waveguide, optical waveguide, and sensor arrangement
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
DE102009016712A1 (en) 2009-04-09 2010-10-14 Bayer Technology Services Gmbh Disposable microfluidic test cassette for bioassay of analytes
AU2010234063A1 (en) 2009-04-09 2011-11-03 Bayer Intellectual Property Gmbh Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins
JP5328915B2 (en) * 2009-07-03 2013-10-30 株式会社日立製作所 High sensitivity fluorescence detection device
CA2977845C (en) 2010-02-23 2020-08-04 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
WO2012018364A1 (en) * 2010-07-08 2012-02-09 The Board Of Trustees Of The University Of Illinois Multi-color fluorescence enhancement from a photonic crystal surface
WO2012151473A2 (en) 2011-05-04 2012-11-08 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
EP2717044A1 (en) * 2012-10-03 2014-04-09 Metrohm Ag Method for detecting analytes
US9568362B2 (en) * 2012-12-19 2017-02-14 Viavi Solutions Inc. Spectroscopic assembly and method
US10197716B2 (en) 2012-12-19 2019-02-05 Viavi Solutions Inc. Metal-dielectric optical filter, sensor device, and fabrication method
TWI537550B (en) * 2013-09-17 2016-06-11 中央研究院 Label-free detection system and applications thereof
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
EP2916125A1 (en) * 2014-03-07 2015-09-09 One Drop Diagnostics Sàrl Fluorescence-detected assays on microfluidic chips
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
JP6772195B2 (en) 2015-06-26 2020-10-21 コニカ ミノルタ ラボラトリー ユー．エス．エー．，インコーポレイテッド Rapid and sensitive bacterial detection
DE102016205335A1 (en) * 2016-03-31 2017-10-05 Siemens Aktiengesellschaft Test kit for bioanalytics and method for the evaluation of such a test kit
US10371896B2 (en) * 2016-12-22 2019-08-06 Magic Leap, Inc. Color separation in planar waveguides using dichroic filters
US20210190772A1 (en) * 2017-01-23 2021-06-24 University Of Louisville Research Foundation, Inc. Electrically-modulated surface waves and an electrode interface comprising a metallic bilayer
CA3070455A1 (en) 2017-07-19 2019-01-24 Evanostics, Llc Cartridges for oral fluid analysis and methods of use
CN107764795B (en) * 2017-12-06 2024-08-09 南京疆昱光电科技有限公司 Explosive fluorescence spectrum detector
CN107966426B (en) * 2017-12-06 2024-07-12 南京疆昱光电科技有限公司 Multichannel trace explosive detector
CA3086538A1 (en) 2017-12-15 2019-06-20 Evanostics Llc Optical reader for analyte testing
CN108375562A (en) * 2018-03-14 2018-08-07 北京普立泰科仪器有限公司 A kind of mercury detector of high measurement accuracy
US12066383B2 (en) 2018-12-18 2024-08-20 Aspida Dx Inc. Optical analyte detection
CN111398239B (en) * 2020-05-19 2022-11-25 威海精讯畅通电子科技有限公司 Dissolved oxygen measuring device based on fluorescence quenching method
US11886022B2 (en) 2020-11-06 2024-01-30 Samsung Electronics Co., Ltd. Beam expander and beam expansion method

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0664059B2 (en) 1982-08-27 1994-08-22 マルティライト リミティド Method for measuring analyte concentration
EP0171148B1 (en) 1984-06-13 1991-04-17 ARES-SERONO RESEARCH & DEVELOPMENT LIMITED PARTNERSHIP Devices for use in chemical test procedures
US4649280A (en) 1985-05-10 1987-03-10 The University Of Rochester Method and system for the enhancement of fluorescence
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US5807755A (en) 1987-08-06 1998-09-15 Multilyte Limited Determination of ambient concentrations of several analytes
US5478755A (en) 1988-07-25 1995-12-26 Ares Serono Research & Development Ltd. Long range surface plasma resonance immunoassay
US5006716A (en) 1989-02-22 1991-04-09 Research Corporation Technologies, Inc. Method and system for directional, enhanced fluorescence from molecular layers
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
CA2087413A1 (en) * 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
GB9212305D0 (en) * 1992-06-10 1992-07-22 Applied Research Systems Sensor for optical assay
CH686747A5 (en) 1993-04-01 1996-06-14 Balzers Hochvakuum An optical layer material.
DK0700514T3 (en) * 1993-05-18 2002-03-25 Univ Utah Res Found Apparatus and Methods for Homogeneous Multi-Analyte Fluoro Immunoassays
GB9314991D0 (en) 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
GB9326450D0 (en) 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
CN1149335A (en) 1994-05-27 1997-05-07 希巴-盖吉股份公司 Process for detecting evanescently excited luminescence
US5459325A (en) * 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
ATE377751T1 (en) * 1995-05-12 2007-11-15 Novartis Erfind Verwalt Gmbh METHOD FOR THE PARALLEL DETERMINATION OF SEVERAL ANALYTES USING EVANESCENTLY EXCITED LUMINESCENCE
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
WO1997035203A1 (en) 1996-03-19 1997-09-25 University Of Utah Research Foundation Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
ATE390491T1 (en) 1996-06-04 2008-04-15 Univ Utah Res Found CONTAINER FOR CARRYING OUT AND OBSERVING BIOLOGICAL PROCESSES
US6342349B1 (en) * 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
US6395558B1 (en) * 1996-08-29 2002-05-28 Zeptosens Ag Optical chemical/biochemical sensor
US6198869B1 (en) 1996-11-18 2001-03-06 Novartis Ag Measuring device and its use
DE19715484A1 (en) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Procedure for applying reagent spots
US5841143A (en) 1997-07-11 1998-11-24 The United States Of America As Represented By Administrator Of The National Aeronautics And Space Administration Integrated fluorescene
US6480639B2 (en) * 1997-09-26 2002-11-12 Nippon Telegraph And Telephone Corp. Optical module
US6200814B1 (en) 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6192168B1 (en) * 1999-04-09 2001-02-20 The United States Of America As Represented By The Secretary Of The Navy Reflectively coated optical waveguide and fluidics cell integration

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955837B2 (en) 2005-10-29 2011-06-07 Bayer Technology Services Gmbh Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof

Also Published As

Publication number Publication date
EP1274986A1 (en) 2003-01-15
JP2003507705A (en) 2003-02-25
US7927868B2 (en) 2011-04-19
ATE516492T1 (en) 2011-07-15
US20100227773A1 (en) 2010-09-09
WO2001013096A1 (en) 2001-02-22
EP1274986B1 (en) 2011-07-13
JP5006494B2 (en) 2012-08-22
US7708945B1 (en) 2010-05-04
ES2367551T3 (en) 2011-11-04

Similar Documents

Publication Publication Date Title
AU6834700A (en) Device and method for determining multiple analytes
WO2000050872A3 (en) A system for cell-based screening
WO2000012123A3 (en) Method and measuring device for determining a plurality of analytes in a sample
WO2000026408A3 (en) A system for cell-based screening
DE69811268D1 (en) SYSTEM AND APPARATUS FOR CARRYING OUT AN ASSAY PROCEDURE
WO1999016781A3 (en) Automatable method for preparing samples which can be universally applied
AU7287298A (en) Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
MX9705534A (en) Diagnostic test carrier with multiple layer test field and method wherein it is used for determining an analyte or substance which is to be analized.
AU9066998A (en) Use of check surfaces for identifying disturbing samples in a detection procedure
EP0957365A4 (en) Fluorescence polarization method
ATE449963T1 (en) IMMUNOASSAY USING SERS (SURFACE ENHANCED RAMAN SCATTERING)
WO2004011607A3 (en) Reagent and method for determination of a substance using an immunoaggregator
MX2007012486A (en) Stilbazium research assays.
WO2004000884A3 (en) Compositions and methods for apo-b48 and apo-b100 assay
EP0753744A3 (en) Immunophilin-bound immunosuppressant assay
IL143098A0 (en) A method of detecting the presence of an analyte in a biological sample
DE602004019060D1 (en) POROSITY AND BIOLOGICAL ACTIVITY OF OBTAINING LUBRICATED MEMBRANES IN AN ASSAY DEVICE FOR MEASURING SERUM CHOLESTERIN ASSOCIATED WITH HIGH-DENSITY LIPOPROTEINS
WO2003050291A3 (en) Sensor for the use in testing biological chemical or environmental samples
PT918991E (en) TEST METHOD
WO2002035228A3 (en) Method and test kit for detecting analytes in a sample
EP2282206A3 (en) Method and apparatus for assaying several analytes simultaneously with an internal control
AUPP660798A0 (en) Method for measuring cellular adhesion
EP0791829A3 (en) Test apparatus for assaying a component in a liquid sample
WO2002048398A3 (en) In situ hybridization system for specifically detecting microorganisms
WO2001096597A3 (en) High throughput screening of compounds for biological activity

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase