JP2001527386A - 異種抗体を産生し得るトランスジェニック非ヒト動物 - Google Patents
異種抗体を産生し得るトランスジェニック非ヒト動物Info
- Publication number
- JP2001527386A JP2001527386A JP52568798A JP52568798A JP2001527386A JP 2001527386 A JP2001527386 A JP 2001527386A JP 52568798 A JP52568798 A JP 52568798A JP 52568798 A JP52568798 A JP 52568798A JP 2001527386 A JP2001527386 A JP 2001527386A
- Authority
- JP
- Japan
- Prior art keywords
- human
- sequence
- gene
- segment
- transgene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/3007—Carcino-embryonic Antigens
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/46—Hybrid immunoglobulins
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- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/90—Stable introduction of foreign DNA into chromosome
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- Biochemistry (AREA)
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- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
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- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/758,417 US6300129B1 (en) | 1990-08-29 | 1996-12-02 | Transgenic non-human animals for producing heterologous antibodies |
| US08/758,417 | 1996-12-02 | ||
| PCT/US1997/021803 WO1998024884A1 (en) | 1996-12-02 | 1997-12-01 | Transgenic non-human animals capable of producing heterologous antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008239776A Division JP2009045066A (ja) | 1996-12-02 | 2008-09-18 | 異種抗体を産生し得るトランスジェニック非ヒト動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001527386A true JP2001527386A (ja) | 2001-12-25 |
| JP2001527386A5 JP2001527386A5 (https=) | 2005-08-11 |
Family
ID=25051673
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52568798A Ceased JP2001527386A (ja) | 1996-12-02 | 1997-12-01 | 異種抗体を産生し得るトランスジェニック非ヒト動物 |
| JP2008239776A Pending JP2009045066A (ja) | 1996-12-02 | 2008-09-18 | 異種抗体を産生し得るトランスジェニック非ヒト動物 |
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| JP2008239776A Pending JP2009045066A (ja) | 1996-12-02 | 2008-09-18 | 異種抗体を産生し得るトランスジェニック非ヒト動物 |
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| US (1) | US6300129B1 (https=) |
| EP (1) | EP0942959A4 (https=) |
| JP (2) | JP2001527386A (https=) |
| AU (1) | AU747370B2 (https=) |
| CA (1) | CA2274105A1 (https=) |
| WO (1) | WO1998024884A1 (https=) |
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- 1997-12-01 CA CA002274105A patent/CA2274105A1/en not_active Abandoned
- 1997-12-01 WO PCT/US1997/021803 patent/WO1998024884A1/en not_active Ceased
- 1997-12-01 EP EP97953058A patent/EP0942959A4/en not_active Withdrawn
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| JP2008544755A (ja) * | 2005-07-01 | 2008-12-11 | メダレックス インコーポレーティッド | プログラム死リガンド1(pd−l1)に対するヒトモノクローナル抗体 |
| US9273135B2 (en) | 2005-07-01 | 2016-03-01 | E. R. Squibb & Sons, L. L. C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
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| JP2018027952A (ja) * | 2005-07-01 | 2018-02-22 | イー・アール・スクイブ・アンド・サンズ・リミテッド・ | プログラム死リガンド1(pd−l1)に対するヒトモノクローナル抗体 |
| JP2009532034A (ja) * | 2006-03-31 | 2009-09-10 | メダレックス インコーポレーティッド | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| JP2010513529A (ja) * | 2006-12-22 | 2010-04-30 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ヒトil−12を結合するヒト抗体及び製造方法 |
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|---|---|
| AU5688198A (en) | 1998-06-29 |
| EP0942959A1 (en) | 1999-09-22 |
| US6300129B1 (en) | 2001-10-09 |
| CA2274105A1 (en) | 1998-06-11 |
| EP0942959A4 (en) | 2005-04-13 |
| JP2009045066A (ja) | 2009-03-05 |
| WO1998024884A1 (en) | 1998-06-11 |
| AU747370B2 (en) | 2002-05-16 |
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