IL115315A - Process for the preparation of non-solvated crystalline forms of benzothiophene derivatives - Google Patents

Process for the preparation of non-solvated crystalline forms of benzothiophene derivatives

Info

Publication number
IL115315A
IL115315A IL11531595A IL11531595A IL115315A IL 115315 A IL115315 A IL 115315A IL 11531595 A IL11531595 A IL 11531595A IL 11531595 A IL11531595 A IL 11531595A IL 115315 A IL115315 A IL 115315A
Authority
IL
Israel
Prior art keywords
preparation
crystalline forms
solvated crystalline
benzothiophene derivatives
benzothiophene
Prior art date
Application number
IL11531595A
Other languages
English (en)
Other versions
IL115315A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26976194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL115315(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/308,325 external-priority patent/US5629425A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IL12528395A priority Critical patent/IL125283A/en
Publication of IL115315A0 publication Critical patent/IL115315A0/xx
Publication of IL115315A publication Critical patent/IL115315A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL11531595A 1994-09-19 1995-09-14 Process for the preparation of non-solvated crystalline forms of benzothiophene derivatives IL115315A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL12528395A IL125283A (en) 1994-09-19 1995-09-14 Process for making crystalline crystalline forms of benzothiophene derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/308,325 US5629425A (en) 1994-09-19 1994-09-19 Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US42791495A 1995-04-26 1995-04-26

Publications (2)

Publication Number Publication Date
IL115315A0 IL115315A0 (en) 1995-12-31
IL115315A true IL115315A (en) 1999-09-22

Family

ID=26976194

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11531595A IL115315A (en) 1994-09-19 1995-09-14 Process for the preparation of non-solvated crystalline forms of benzothiophene derivatives
IL12528395A IL125283A (en) 1994-09-19 1995-09-14 Process for making crystalline crystalline forms of benzothiophene derivatives
IL11531495A IL115314A (en) 1994-09-19 1995-09-14 Crystalline 6-hydroxy-2-(4-hydroxy-phenyl)-3-¬4-(2-piperidinethoxy)benzoyl¾benzo ¬b¾ thiophene hydrochloride

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL12528395A IL125283A (en) 1994-09-19 1995-09-14 Process for making crystalline crystalline forms of benzothiophene derivatives
IL11531495A IL115314A (en) 1994-09-19 1995-09-14 Crystalline 6-hydroxy-2-(4-hydroxy-phenyl)-3-¬4-(2-piperidinethoxy)benzoyl¾benzo ¬b¾ thiophene hydrochloride

Country Status (51)

Country Link
US (4) US5731327A (et)
JP (2) JPH08193081A (et)
KR (2) KR100367376B1 (et)
CN (2) CN1075069C (et)
AP (1) AP754A (et)
AT (2) AT407988B (et)
AU (3) AU691955B2 (et)
BE (2) BE1009626A3 (et)
BG (1) BG62793B1 (et)
BR (2) BR9504059A (et)
CA (2) CA2158400C (et)
CH (3) CH691594A5 (et)
CO (2) CO4410190A1 (et)
CZ (2) CZ290343B6 (et)
DE (3) DE19549755B4 (et)
DK (4) DK175897B1 (et)
EE (1) EE03386B1 (et)
EG (1) EG23763A (et)
ES (2) ES2109882B1 (et)
FI (2) FI112226B (et)
FR (2) FR2732020B1 (et)
GB (2) GB2293602B (et)
GE (1) GEP19991821B (et)
GR (2) GR1002697B (et)
HK (1) HK1019009A1 (et)
HR (2) HRP950482B1 (et)
HU (2) HU227683B1 (et)
IE (2) IE80883B1 (et)
IL (3) IL115315A (et)
IS (1) IS1788B (et)
IT (2) IT1277601B1 (et)
LU (2) LU88661A1 (et)
LV (2) LV11178B (et)
MY (1) MY116371A (et)
NL (2) NL1001196C2 (et)
NO (2) NO308107B1 (et)
NZ (2) NZ280028A (et)
OA (1) OA10406A (et)
PE (2) PE14796A1 (et)
PL (2) PL187686B1 (et)
PT (2) PT101770B (et)
RO (2) RO115260B1 (et)
RS (2) RS49578B (et)
SE (2) SE520721C2 (et)
SI (2) SI9500292A (et)
SK (1) SK283502B6 (et)
TR (1) TR199501136A2 (et)
TW (1) TW412534B (et)
UA (2) UA44240C2 (et)
UY (1) UY24040A1 (et)
WO (1) WO1996009045A1 (et)

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RU2203060C2 (ru) 1996-10-30 2003-04-27 Эли Лилли Энд Компани Способ профилактики рака молочной железы
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US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004029784A1 (de) 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004030502A1 (de) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
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US20060074088A1 (en) 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
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US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US7728134B2 (en) 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
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PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
CA2873524C (en) 2006-05-04 2018-02-20 Boehringer Ingelheim International Gmbh A polymeric form of 1-((4-methyl-quinazolin-2-yl)methyl)-3-7-(2-butyn-1-yl)-8-(3-(r)-aminopiperidin-1-yl)xanthine
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
WO2008047105A1 (en) * 2006-10-17 2008-04-24 Cipla Limited Crystalline form of benzothiophene compound and process for preparation thereof
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
DE102007032451B4 (de) 2007-07-12 2010-09-30 Icfs Gmbh Verfahren zur Herstellung von aromatischen Ketonen
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PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
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UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
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EP2314581B1 (en) 2009-10-23 2012-07-25 Hexal AG A process for preparing benzo[b]thiophene derivatives
CN102753161A (zh) 2009-11-27 2012-10-24 贝林格尔.英格海姆国际有限公司 基因型糖尿病患者利用dpp-iv抑制剂例如利拉利汀的治疗
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US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
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Also Published As

Publication number Publication date
KR960010634A (ko) 1996-04-20
NO953657L (no) 1996-03-20
ITMI951936A0 (it) 1995-09-15
ATA154295A (de) 2000-12-15
UA42716C2 (uk) 2001-11-15
LV11177B (en) 1996-08-20
IL115315A0 (en) 1995-12-31
CA2158400C (en) 2006-10-24
AU3718695A (en) 1996-04-09
CA2158399C (en) 2001-03-20
DK175886B1 (da) 2005-05-23
PT101770B (pt) 1997-04-30
SE509265C2 (sv) 1998-12-21
CN1068324C (zh) 2001-07-11
KR100381346B1 (ko) 2004-04-13
AP754A (en) 1999-07-22
PT101771A (pt) 1996-04-30
AU692907B2 (en) 1998-06-18
JPH08176147A (ja) 1996-07-09
HU9502723D0 (en) 1995-11-28
LU88660A1 (fr) 1996-07-15
HK1019009A1 (en) 2000-01-14
BG62793B1 (bg) 2000-08-31
HU227683B1 (en) 2011-11-28
CZ240295A3 (en) 1996-04-17
FR2732020B1 (fr) 1997-11-14
DE19534745A1 (de) 1996-04-04
RS49513B (sr) 2006-10-27
PL310517A1 (en) 1996-04-01
YU61395A (sh) 1998-09-18
BR9504060A (pt) 1996-09-24
FI954403A (fi) 1996-03-20
BE1009626A3 (fr) 1997-06-03
SE9503213D0 (sv) 1995-09-15
NL1001194A1 (nl) 1996-03-19
SE9503214D0 (sv) 1995-09-15
PL187686B1 (pl) 2004-09-30
CZ240395A3 (en) 1996-04-17
CH691478A5 (de) 2001-07-31
ES2109882B1 (es) 1998-08-16
LV11177A (lv) 1996-04-20
GB2293602B (en) 1998-05-06
EG23763A (en) 2007-08-08
IS1788B (is) 2001-11-28
GR1002709B (el) 1997-06-04
IE950721A1 (en) 1996-03-20
CO4410191A1 (es) 1997-01-09
FR2724655B1 (fr) 1997-11-14
HU9502721D0 (en) 1995-11-28
AT502957A1 (de) 2007-06-15
CN1132205A (zh) 1996-10-02
PT101771B (pt) 1997-04-30
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PE32796A1 (es) 1996-08-07
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FI954403A0 (fi) 1995-09-18
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RO115259B1 (ro) 1999-12-30
PL310518A1 (en) 1996-04-01
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HRP950483A2 (en) 1997-10-31
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